Cranial bone regeneration according to different particle sizes and densities of demineralized dentin matrix in the rabbit model
Identifieur interne : 000D33 ( Pmc/Curation ); précédent : 000D32; suivant : 000D34Cranial bone regeneration according to different particle sizes and densities of demineralized dentin matrix in the rabbit model
Auteurs : Jin-Woo Nam ; Moon-Young Kim ; Se-Jin HanSource :
- Maxillofacial Plastic and Reconstructive Surgery [ 2288-8101 ] ; 2016.
Abstract
The objective of this study was to place bone graft materials in cranial defects in a rabbit model and compare their bone regenerating ability according to the size and density of demineralized dentin matrix (DDM).
We selected nine healthy male rabbits that were raised under the same conditions and that weighed about 3 kg. Two circular defects 8 mm in diameter were created in each side of the cranium. The defects were grafted with DDM using four different particle sizes and densities: 0.1 mL of 0.25- to 1.0-mm particles (group 1); 0.2 mL of 0.25- to 1.0-mm particles (group 2); 0.1 mL of 1.0- to 2.0-mm particles (group 3); and 0.2 mL of 1.0- to 2.0-mm particles (group 4). After 2, 4, and 8 weeks, the rabbits were sacrificed, and bone samples were evaluated by means of histologic, histomorphometric, and quantitative RT-PCR analysis.
In group 1, osteoblast activity and bone formation were greater than in the other three groups on histological examination. In groups 2, 3, and 4, dense connective tissue was seen around original bone even after 8 weeks. Histomorphometric analysis of representative sections in group 1 showed a higher rate of new bone formation, but the difference from the other groups was not statistically significant. RT-PCR analysis indicated a correlation between bone formation and protein (osteonectin and osteopontin) expression.
DDM with a space between particles of 200 μm was effective in bone formation, suggesting that materials with a small particle size could reasonably be used for bone grafting.
Url:
DOI: 10.1186/s40902-016-0073-1
PubMed: 27441186
PubMed Central: 4932123
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Jin-Woo Nam<affiliation><nlm:aff id="Aff1">Department of Oral and Maxillofacial Surgery, College of Dentistry, Dankook University, 119 Dandae-ro, Dongnam-gu, Cheonan, Chungnam South Korea</nlm:aff>
<wicri:noCountry code="subfield">Chungnam South Korea</wicri:noCountry>
</affiliation>
<affiliation><nlm:aff id="Aff1">Department of Oral and Maxillofacial Surgery, College of Dentistry, Dankook University, 119 Dandae-ro, Dongnam-gu, Cheonan, Chungnam South Korea</nlm:aff>
<wicri:noCountry code="subfield">Chungnam South Korea</wicri:noCountry>
</affiliation>
<affiliation><nlm:aff id="Aff1">Department of Oral and Maxillofacial Surgery, College of Dentistry, Dankook University, 119 Dandae-ro, Dongnam-gu, Cheonan, Chungnam South Korea</nlm:aff>
<wicri:noCountry code="subfield">Chungnam South Korea</wicri:noCountry>
</affiliation>
Le document en format XML
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<author><name sortKey="Nam, Jin Woo" sort="Nam, Jin Woo" uniqKey="Nam J" first="Jin-Woo" last="Nam">Jin-Woo Nam</name>
<affiliation><nlm:aff id="Aff1">Department of Oral and Maxillofacial Surgery, College of Dentistry, Dankook University, 119 Dandae-ro, Dongnam-gu, Cheonan, Chungnam South Korea</nlm:aff>
<wicri:noCountry code="subfield">Chungnam South Korea</wicri:noCountry>
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<author><name sortKey="Kim, Moon Young" sort="Kim, Moon Young" uniqKey="Kim M" first="Moon-Young" last="Kim">Moon-Young Kim</name>
<affiliation><nlm:aff id="Aff1">Department of Oral and Maxillofacial Surgery, College of Dentistry, Dankook University, 119 Dandae-ro, Dongnam-gu, Cheonan, Chungnam South Korea</nlm:aff>
<wicri:noCountry code="subfield">Chungnam South Korea</wicri:noCountry>
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<author><name sortKey="Han, Se Jin" sort="Han, Se Jin" uniqKey="Han S" first="Se-Jin" last="Han">Se-Jin Han</name>
<affiliation><nlm:aff id="Aff1">Department of Oral and Maxillofacial Surgery, College of Dentistry, Dankook University, 119 Dandae-ro, Dongnam-gu, Cheonan, Chungnam South Korea</nlm:aff>
<wicri:noCountry code="subfield">Chungnam South Korea</wicri:noCountry>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Cranial bone regeneration according to different particle sizes and densities of demineralized dentin matrix in the rabbit model</title>
<author><name sortKey="Nam, Jin Woo" sort="Nam, Jin Woo" uniqKey="Nam J" first="Jin-Woo" last="Nam">Jin-Woo Nam</name>
<affiliation><nlm:aff id="Aff1">Department of Oral and Maxillofacial Surgery, College of Dentistry, Dankook University, 119 Dandae-ro, Dongnam-gu, Cheonan, Chungnam South Korea</nlm:aff>
<wicri:noCountry code="subfield">Chungnam South Korea</wicri:noCountry>
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<author><name sortKey="Kim, Moon Young" sort="Kim, Moon Young" uniqKey="Kim M" first="Moon-Young" last="Kim">Moon-Young Kim</name>
<affiliation><nlm:aff id="Aff1">Department of Oral and Maxillofacial Surgery, College of Dentistry, Dankook University, 119 Dandae-ro, Dongnam-gu, Cheonan, Chungnam South Korea</nlm:aff>
<wicri:noCountry code="subfield">Chungnam South Korea</wicri:noCountry>
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<author><name sortKey="Han, Se Jin" sort="Han, Se Jin" uniqKey="Han S" first="Se-Jin" last="Han">Se-Jin Han</name>
<affiliation><nlm:aff id="Aff1">Department of Oral and Maxillofacial Surgery, College of Dentistry, Dankook University, 119 Dandae-ro, Dongnam-gu, Cheonan, Chungnam South Korea</nlm:aff>
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<series><title level="j">Maxillofacial Plastic and Reconstructive Surgery</title>
<idno type="ISSN">2288-8101</idno>
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<front><div type="abstract" xml:lang="en"><sec><title>Background</title>
<p>The objective of this study was to place bone graft materials in cranial defects in a rabbit model and compare their bone regenerating ability according to the size and density of demineralized dentin matrix (DDM).</p>
</sec>
<sec><title>Methods</title>
<p>We selected nine healthy male rabbits that were raised under the same conditions and that weighed about 3 kg. Two circular defects 8 mm in diameter were created in each side of the cranium. The defects were grafted with DDM using four different particle sizes and densities: 0.1 mL of 0.25- to 1.0-mm particles (group 1); 0.2 mL of 0.25- to 1.0-mm particles (group 2); 0.1 mL of 1.0- to 2.0-mm particles (group 3); and 0.2 mL of 1.0- to 2.0-mm particles (group 4). After 2, 4, and 8 weeks, the rabbits were sacrificed, and bone samples were evaluated by means of histologic, histomorphometric, and quantitative RT-PCR analysis.</p>
</sec>
<sec><title>Results</title>
<p>In group 1, osteoblast activity and bone formation were greater than in the other three groups on histological examination. In groups 2, 3, and 4, dense connective tissue was seen around original bone even after 8 weeks. Histomorphometric analysis of representative sections in group 1 showed a higher rate of new bone formation, but the difference from the other groups was not statistically significant. RT-PCR analysis indicated a correlation between bone formation and protein (osteonectin and osteopontin) expression.</p>
</sec>
<sec><title>Conclusions</title>
<p>DDM with a space between particles of 200 μm was effective in bone formation, suggesting that materials with a small particle size could reasonably be used for bone grafting.</p>
</sec>
</div>
</front>
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<front><journal-meta><journal-id journal-id-type="nlm-ta">Maxillofac Plast Reconstr Surg</journal-id>
<journal-id journal-id-type="iso-abbrev">Maxillofac Plast Reconstr Surg</journal-id>
<journal-title-group><journal-title>Maxillofacial Plastic and Reconstructive Surgery</journal-title>
</journal-title-group>
<issn pub-type="ppub">2288-8101</issn>
<issn pub-type="epub">2288-8586</issn>
<publisher><publisher-name>Springer Berlin Heidelberg</publisher-name>
<publisher-loc>Berlin/Heidelberg</publisher-loc>
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<article-meta><article-id pub-id-type="pmid">27441186</article-id>
<article-id pub-id-type="pmc">4932123</article-id>
<article-id pub-id-type="publisher-id">73</article-id>
<article-id pub-id-type="doi">10.1186/s40902-016-0073-1</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Research</subject>
</subj-group>
</article-categories>
<title-group><article-title>Cranial bone regeneration according to different particle sizes and densities of demineralized dentin matrix in the rabbit model</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Nam</surname>
<given-names>Jin-Woo</given-names>
</name>
<address><phone>+82-41-550-0271</phone>
<email>wlsdnska@hanmail.net</email>
</address>
<xref ref-type="aff" rid="Aff1"></xref>
</contrib>
<contrib contrib-type="author"><name><surname>Kim</surname>
<given-names>Moon-Young</given-names>
</name>
<address><email>rechare@hanmail.net</email>
</address>
<xref ref-type="aff" rid="Aff1"></xref>
</contrib>
<contrib contrib-type="author" corresp="yes"><name><surname>Han</surname>
<given-names>Se-Jin</given-names>
</name>
<address><phone>+82-41-550-1996</phone>
<email>hanimplant@dankook.ac.kr</email>
</address>
<xref ref-type="aff" rid="Aff1"></xref>
</contrib>
<aff id="Aff1">Department of Oral and Maxillofacial Surgery, College of Dentistry, Dankook University, 119 Dandae-ro, Dongnam-gu, Cheonan, Chungnam South Korea</aff>
</contrib-group>
<pub-date pub-type="epub"><day>5</day>
<month>7</month>
<year>2016</year>
</pub-date>
<pub-date pub-type="pmc-release"><day>5</day>
<month>7</month>
<year>2016</year>
</pub-date>
<pub-date pub-type="collection"><month>12</month>
<year>2016</year>
</pub-date>
<volume>38</volume>
<issue>1</issue>
<elocation-id>27</elocation-id>
<history><date date-type="received"><day>19</day>
<month>4</month>
<year>2016</year>
</date>
<date date-type="accepted"><day>20</day>
<month>6</month>
<year>2016</year>
</date>
</history>
<permissions><copyright-statement>© The Author(s). 2016</copyright-statement>
<license license-type="OpenAccess"><license-p><bold>Open Access</bold>
This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (<ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by/4.0/">http://creativecommons.org/licenses/by/4.0/</ext-link>
), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.</license-p>
</license>
</permissions>
<abstract id="Abs1"><sec><title>Background</title>
<p>The objective of this study was to place bone graft materials in cranial defects in a rabbit model and compare their bone regenerating ability according to the size and density of demineralized dentin matrix (DDM).</p>
</sec>
<sec><title>Methods</title>
<p>We selected nine healthy male rabbits that were raised under the same conditions and that weighed about 3 kg. Two circular defects 8 mm in diameter were created in each side of the cranium. The defects were grafted with DDM using four different particle sizes and densities: 0.1 mL of 0.25- to 1.0-mm particles (group 1); 0.2 mL of 0.25- to 1.0-mm particles (group 2); 0.1 mL of 1.0- to 2.0-mm particles (group 3); and 0.2 mL of 1.0- to 2.0-mm particles (group 4). After 2, 4, and 8 weeks, the rabbits were sacrificed, and bone samples were evaluated by means of histologic, histomorphometric, and quantitative RT-PCR analysis.</p>
</sec>
<sec><title>Results</title>
<p>In group 1, osteoblast activity and bone formation were greater than in the other three groups on histological examination. In groups 2, 3, and 4, dense connective tissue was seen around original bone even after 8 weeks. Histomorphometric analysis of representative sections in group 1 showed a higher rate of new bone formation, but the difference from the other groups was not statistically significant. RT-PCR analysis indicated a correlation between bone formation and protein (osteonectin and osteopontin) expression.</p>
</sec>
<sec><title>Conclusions</title>
<p>DDM with a space between particles of 200 μm was effective in bone formation, suggesting that materials with a small particle size could reasonably be used for bone grafting.</p>
</sec>
</abstract>
<kwd-group xml:lang="en"><title>Keywords</title>
<kwd>Demineralized dentin matrix</kwd>
<kwd>Bone regeneration</kwd>
<kwd>Osteoinduction</kwd>
<kwd>Particle size</kwd>
</kwd-group>
<custom-meta-group><custom-meta><meta-name>issue-copyright-statement</meta-name>
<meta-value>© The Author(s) 2016</meta-value>
</custom-meta>
</custom-meta-group>
</article-meta>
</front>
</pmc>
</record>
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