Estrogen deficiency reduces the dentinogenic capacity of rat lower incisors
Identifieur interne : 000D18 ( Pmc/Curation ); précédent : 000D17; suivant : 000D19Estrogen deficiency reduces the dentinogenic capacity of rat lower incisors
Auteurs : Tao Xu ; Ming Yan ; Yanping Wang ; Zhanwei Wang [États-Unis] ; Lizhe Xie ; Chunbo Tang ; Guangdong Zhang ; Jinhua YuSource :
- Journal of Molecular Histology [ 1567-2379 ] ; 2013.
Abstract
Endogenous estrogen deficiency usually causes the systemic osteoporosis including the jaw bones. However, it remains unclear whether estrogen deficiency can affect the tooth mineralization. In this study, the classical osteoporotic rat model was established via the ovariectomy, which was subsequently confirmed by the detection of serum estradiol levels and body weights. The mineralization-related assays were performed to observe the potential changes in mineralized tissues of rat lower incisors. The clinical crown length, compressive strength, radiodensity, and calcium content in the ovariectomy group (OVX) were significantly downregulated (
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DOI: 10.1007/s10735-013-9533-4
PubMed: 23974864
PubMed Central: 4544579
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Tao Xu<affiliation><nlm:aff id="Aff1">Institute of Stomatology, Nanjing Medical University, 140 Hanzhong Road, Nanjing, 210029 Jiangsu China</nlm:aff><wicri:noCountry code="subfield">210029 Jiangsu China</wicri:noCountry></affiliation><affiliation><nlm:aff id="Aff2">Department of Stomatology, Nanjing Governmental Hospital, 116 Chengxian Road, Nanjing, 210018 Jiangsu China</nlm:aff><wicri:noCountry code="subfield">210018 Jiangsu China</wicri:noCountry></affiliation><affiliation><nlm:aff id="Aff2">Department of Stomatology, Nanjing Governmental Hospital, 116 Chengxian Road, Nanjing, 210018 Jiangsu China</nlm:aff><wicri:noCountry code="subfield">210018 Jiangsu China</wicri:noCountry></affiliation><affiliation><nlm:aff id="Aff1">Institute of Stomatology, Nanjing Medical University, 140 Hanzhong Road, Nanjing, 210029 Jiangsu China</nlm:aff><wicri:noCountry code="subfield">210029 Jiangsu China</wicri:noCountry></affiliation><affiliation><nlm:aff id="Aff3">Department of Endodontics, School of Stomatology, Nanjing Medical University, 136 Hanzhong Road, Nanjing, 210029 Jiangsu China</nlm:aff><wicri:noCountry code="subfield">210029 Jiangsu China</wicri:noCountry></affiliation><affiliation><nlm:aff id="Aff3">Department of Endodontics, School of Stomatology, Nanjing Medical University, 136 Hanzhong Road, Nanjing, 210029 Jiangsu China</nlm:aff><wicri:noCountry code="subfield">210029 Jiangsu China</wicri:noCountry></affiliation><affiliation><nlm:aff id="Aff1">Institute of Stomatology, Nanjing Medical University, 140 Hanzhong Road, Nanjing, 210029 Jiangsu China</nlm:aff><wicri:noCountry code="subfield">210029 Jiangsu China</wicri:noCountry></affiliation><affiliation><nlm:aff id="Aff4">Department of Endodontics, Suzhou Stomatological Hospital, 1505 Renmin Road, Suzhou, 215005 Jiangsu China</nlm:aff><wicri:noCountry code="subfield">215005 Jiangsu China</wicri:noCountry></affiliation><affiliation><nlm:aff id="Aff4">Department of Endodontics, Suzhou Stomatological Hospital, 1505 Renmin Road, Suzhou, 215005 Jiangsu China</nlm:aff><wicri:noCountry code="subfield">215005 Jiangsu China</wicri:noCountry></affiliation><affiliation><nlm:aff id="Aff1">Institute of Stomatology, Nanjing Medical University, 140 Hanzhong Road, Nanjing, 210029 Jiangsu China</nlm:aff><wicri:noCountry code="subfield">210029 Jiangsu China</wicri:noCountry></affiliation><affiliation><nlm:aff id="Aff1">Institute of Stomatology, Nanjing Medical University, 140 Hanzhong Road, Nanjing, 210029 Jiangsu China</nlm:aff><wicri:noCountry code="subfield">210029 Jiangsu China</wicri:noCountry></affiliation><affiliation><nlm:aff id="Aff6">Department of Prosthodontics, School of Stomatology, Nanjing Medical University, 136 Hanzhong Road, Nanjing, 210029 Jiangsu China</nlm:aff><wicri:noCountry code="subfield">210029 Jiangsu China</wicri:noCountry></affiliation><affiliation><nlm:aff id="Aff6">Department of Prosthodontics, School of Stomatology, Nanjing Medical University, 136 Hanzhong Road, Nanjing, 210029 Jiangsu China</nlm:aff><wicri:noCountry code="subfield">210029 Jiangsu China</wicri:noCountry></affiliation><affiliation><nlm:aff id="Aff1">Institute of Stomatology, Nanjing Medical University, 140 Hanzhong Road, Nanjing, 210029 Jiangsu China</nlm:aff><wicri:noCountry code="subfield">210029 Jiangsu China</wicri:noCountry></affiliation><affiliation><nlm:aff id="Aff3">Department of Endodontics, School of Stomatology, Nanjing Medical University, 136 Hanzhong Road, Nanjing, 210029 Jiangsu China</nlm:aff><wicri:noCountry code="subfield">210029 Jiangsu China</wicri:noCountry></affiliation><affiliation><nlm:aff id="Aff3">Department of Endodontics, School of Stomatology, Nanjing Medical University, 136 Hanzhong Road, Nanjing, 210029 Jiangsu China</nlm:aff><wicri:noCountry code="subfield">210029 Jiangsu China</wicri:noCountry></affiliation><affiliation><nlm:aff id="Aff1">Institute of Stomatology, Nanjing Medical University, 140 Hanzhong Road, Nanjing, 210029 Jiangsu China</nlm:aff><wicri:noCountry code="subfield">210029 Jiangsu China</wicri:noCountry></affiliation><affiliation><nlm:aff id="Aff3">Department of Endodontics, School of Stomatology, Nanjing Medical University, 136 Hanzhong Road, Nanjing, 210029 Jiangsu China</nlm:aff><wicri:noCountry code="subfield">210029 Jiangsu China</wicri:noCountry></affiliation><affiliation><nlm:aff id="Aff3">Department of Endodontics, School of Stomatology, Nanjing Medical University, 136 Hanzhong Road, Nanjing, 210029 Jiangsu China</nlm:aff><wicri:noCountry code="subfield">210029 Jiangsu China</wicri:noCountry></affiliation>Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Estrogen deficiency reduces the dentinogenic capacity of rat lower incisors</title><author><name sortKey="Xu, Tao" sort="Xu, Tao" uniqKey="Xu T" first="Tao" last="Xu">Tao Xu</name><affiliation><nlm:aff id="Aff1">Institute of Stomatology, Nanjing Medical University, 140 Hanzhong Road, Nanjing, 210029 Jiangsu China</nlm:aff><wicri:noCountry code="subfield">210029 Jiangsu China</wicri:noCountry></affiliation><affiliation><nlm:aff id="Aff2">Department of Stomatology, Nanjing Governmental Hospital, 116 Chengxian Road, Nanjing, 210018 Jiangsu China</nlm:aff><wicri:noCountry code="subfield">210018 Jiangsu China</wicri:noCountry></affiliation></author><author><name sortKey="Yan, Ming" sort="Yan, Ming" uniqKey="Yan M" first="Ming" last="Yan">Ming Yan</name><affiliation><nlm:aff id="Aff1">Institute of Stomatology, Nanjing Medical University, 140 Hanzhong Road, Nanjing, 210029 Jiangsu China</nlm:aff><wicri:noCountry code="subfield">210029 Jiangsu China</wicri:noCountry></affiliation><affiliation><nlm:aff id="Aff3">Department of Endodontics, School of Stomatology, Nanjing Medical University, 136 Hanzhong Road, Nanjing, 210029 Jiangsu China</nlm:aff><wicri:noCountry code="subfield">210029 Jiangsu China</wicri:noCountry></affiliation></author><author><name sortKey="Wang, Yanping" sort="Wang, Yanping" uniqKey="Wang Y" first="Yanping" last="Wang">Yanping Wang</name><affiliation><nlm:aff id="Aff1">Institute of Stomatology, Nanjing Medical University, 140 Hanzhong Road, Nanjing, 210029 Jiangsu China</nlm:aff><wicri:noCountry code="subfield">210029 Jiangsu China</wicri:noCountry></affiliation><affiliation><nlm:aff id="Aff4">Department of Endodontics, Suzhou Stomatological Hospital, 1505 Renmin Road, Suzhou, 215005 Jiangsu China</nlm:aff><wicri:noCountry code="subfield">215005 Jiangsu China</wicri:noCountry></affiliation></author><author><name sortKey="Wang, Zhanwei" sort="Wang, Zhanwei" uniqKey="Wang Z" first="Zhanwei" last="Wang">Zhanwei Wang</name><affiliation wicri:level="2"><nlm:aff id="Aff5">Cancer Biology Program, University of Hawaii Cancer Center, 701 Ilalo Street, Honolulu, HI 96813 USA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Hawaï</region></placeName><wicri:cityArea>Cancer Biology Program, University of Hawaii Cancer Center, 701 Ilalo Street, Honolulu</wicri:cityArea></affiliation></author><author><name sortKey="Xie, Lizhe" sort="Xie, Lizhe" uniqKey="Xie L" first="Lizhe" last="Xie">Lizhe Xie</name><affiliation><nlm:aff id="Aff1">Institute of Stomatology, Nanjing Medical University, 140 Hanzhong Road, Nanjing, 210029 Jiangsu China</nlm:aff><wicri:noCountry code="subfield">210029 Jiangsu China</wicri:noCountry></affiliation></author><author><name sortKey="Tang, Chunbo" sort="Tang, Chunbo" uniqKey="Tang C" first="Chunbo" last="Tang">Chunbo Tang</name><affiliation><nlm:aff id="Aff1">Institute of Stomatology, Nanjing Medical University, 140 Hanzhong Road, Nanjing, 210029 Jiangsu China</nlm:aff><wicri:noCountry code="subfield">210029 Jiangsu China</wicri:noCountry></affiliation><affiliation><nlm:aff id="Aff6">Department of Prosthodontics, School of Stomatology, Nanjing Medical University, 136 Hanzhong Road, Nanjing, 210029 Jiangsu China</nlm:aff><wicri:noCountry code="subfield">210029 Jiangsu China</wicri:noCountry></affiliation></author><author><name sortKey="Zhang, Guangdong" sort="Zhang, Guangdong" uniqKey="Zhang G" first="Guangdong" last="Zhang">Guangdong Zhang</name><affiliation><nlm:aff id="Aff1">Institute of Stomatology, Nanjing Medical University, 140 Hanzhong Road, Nanjing, 210029 Jiangsu China</nlm:aff><wicri:noCountry code="subfield">210029 Jiangsu China</wicri:noCountry></affiliation><affiliation><nlm:aff id="Aff3">Department of Endodontics, School of Stomatology, Nanjing Medical University, 136 Hanzhong Road, Nanjing, 210029 Jiangsu China</nlm:aff><wicri:noCountry code="subfield">210029 Jiangsu China</wicri:noCountry></affiliation></author><author><name sortKey="Yu, Jinhua" sort="Yu, Jinhua" uniqKey="Yu J" first="Jinhua" last="Yu">Jinhua Yu</name><affiliation><nlm:aff id="Aff1">Institute of Stomatology, Nanjing Medical University, 140 Hanzhong Road, Nanjing, 210029 Jiangsu China</nlm:aff><wicri:noCountry code="subfield">210029 Jiangsu China</wicri:noCountry></affiliation><affiliation><nlm:aff id="Aff3">Department of Endodontics, School of Stomatology, Nanjing Medical University, 136 Hanzhong Road, Nanjing, 210029 Jiangsu China</nlm:aff><wicri:noCountry code="subfield">210029 Jiangsu China</wicri:noCountry></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">23974864</idno><idno type="pmc">4544579</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4544579</idno><idno type="RBID">PMC:4544579</idno><idno type="doi">10.1007/s10735-013-9533-4</idno><date when="2013">2013</date><idno type="wicri:Area/Pmc/Corpus">000D18</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000D18</idno><idno type="wicri:Area/Pmc/Curation">000D18</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000D18</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Estrogen deficiency reduces the dentinogenic capacity of rat lower incisors</title><author><name sortKey="Xu, Tao" sort="Xu, Tao" uniqKey="Xu T" first="Tao" last="Xu">Tao Xu</name><affiliation><nlm:aff id="Aff1">Institute of Stomatology, Nanjing Medical University, 140 Hanzhong Road, Nanjing, 210029 Jiangsu China</nlm:aff><wicri:noCountry code="subfield">210029 Jiangsu China</wicri:noCountry></affiliation><affiliation><nlm:aff id="Aff2">Department of Stomatology, Nanjing Governmental Hospital, 116 Chengxian Road, Nanjing, 210018 Jiangsu China</nlm:aff><wicri:noCountry code="subfield">210018 Jiangsu China</wicri:noCountry></affiliation></author><author><name sortKey="Yan, Ming" sort="Yan, Ming" uniqKey="Yan M" first="Ming" last="Yan">Ming Yan</name><affiliation><nlm:aff id="Aff1">Institute of Stomatology, Nanjing Medical University, 140 Hanzhong Road, Nanjing, 210029 Jiangsu China</nlm:aff><wicri:noCountry code="subfield">210029 Jiangsu China</wicri:noCountry></affiliation><affiliation><nlm:aff id="Aff3">Department of Endodontics, School of Stomatology, Nanjing Medical University, 136 Hanzhong Road, Nanjing, 210029 Jiangsu China</nlm:aff><wicri:noCountry code="subfield">210029 Jiangsu China</wicri:noCountry></affiliation></author><author><name sortKey="Wang, Yanping" sort="Wang, Yanping" uniqKey="Wang Y" first="Yanping" last="Wang">Yanping Wang</name><affiliation><nlm:aff id="Aff1">Institute of Stomatology, Nanjing Medical University, 140 Hanzhong Road, Nanjing, 210029 Jiangsu China</nlm:aff><wicri:noCountry code="subfield">210029 Jiangsu China</wicri:noCountry></affiliation><affiliation><nlm:aff id="Aff4">Department of Endodontics, Suzhou Stomatological Hospital, 1505 Renmin Road, Suzhou, 215005 Jiangsu China</nlm:aff><wicri:noCountry code="subfield">215005 Jiangsu China</wicri:noCountry></affiliation></author><author><name sortKey="Wang, Zhanwei" sort="Wang, Zhanwei" uniqKey="Wang Z" first="Zhanwei" last="Wang">Zhanwei Wang</name><affiliation wicri:level="2"><nlm:aff id="Aff5">Cancer Biology Program, University of Hawaii Cancer Center, 701 Ilalo Street, Honolulu, HI 96813 USA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Hawaï</region></placeName><wicri:cityArea>Cancer Biology Program, University of Hawaii Cancer Center, 701 Ilalo Street, Honolulu</wicri:cityArea></affiliation></author><author><name sortKey="Xie, Lizhe" sort="Xie, Lizhe" uniqKey="Xie L" first="Lizhe" last="Xie">Lizhe Xie</name><affiliation><nlm:aff id="Aff1">Institute of Stomatology, Nanjing Medical University, 140 Hanzhong Road, Nanjing, 210029 Jiangsu China</nlm:aff><wicri:noCountry code="subfield">210029 Jiangsu China</wicri:noCountry></affiliation></author><author><name sortKey="Tang, Chunbo" sort="Tang, Chunbo" uniqKey="Tang C" first="Chunbo" last="Tang">Chunbo Tang</name><affiliation><nlm:aff id="Aff1">Institute of Stomatology, Nanjing Medical University, 140 Hanzhong Road, Nanjing, 210029 Jiangsu China</nlm:aff><wicri:noCountry code="subfield">210029 Jiangsu China</wicri:noCountry></affiliation><affiliation><nlm:aff id="Aff6">Department of Prosthodontics, School of Stomatology, Nanjing Medical University, 136 Hanzhong Road, Nanjing, 210029 Jiangsu China</nlm:aff><wicri:noCountry code="subfield">210029 Jiangsu China</wicri:noCountry></affiliation></author><author><name sortKey="Zhang, Guangdong" sort="Zhang, Guangdong" uniqKey="Zhang G" first="Guangdong" last="Zhang">Guangdong Zhang</name><affiliation><nlm:aff id="Aff1">Institute of Stomatology, Nanjing Medical University, 140 Hanzhong Road, Nanjing, 210029 Jiangsu China</nlm:aff><wicri:noCountry code="subfield">210029 Jiangsu China</wicri:noCountry></affiliation><affiliation><nlm:aff id="Aff3">Department of Endodontics, School of Stomatology, Nanjing Medical University, 136 Hanzhong Road, Nanjing, 210029 Jiangsu China</nlm:aff><wicri:noCountry code="subfield">210029 Jiangsu China</wicri:noCountry></affiliation></author><author><name sortKey="Yu, Jinhua" sort="Yu, Jinhua" uniqKey="Yu J" first="Jinhua" last="Yu">Jinhua Yu</name><affiliation><nlm:aff id="Aff1">Institute of Stomatology, Nanjing Medical University, 140 Hanzhong Road, Nanjing, 210029 Jiangsu China</nlm:aff><wicri:noCountry code="subfield">210029 Jiangsu China</wicri:noCountry></affiliation><affiliation><nlm:aff id="Aff3">Department of Endodontics, School of Stomatology, Nanjing Medical University, 136 Hanzhong Road, Nanjing, 210029 Jiangsu China</nlm:aff><wicri:noCountry code="subfield">210029 Jiangsu China</wicri:noCountry></affiliation></author></analytic><series><title level="j">Journal of Molecular Histology</title><idno type="ISSN">1567-2379</idno><idno type="eISSN">1567-2387</idno><imprint><date when="2013">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Endogenous estrogen deficiency usually causes the systemic osteoporosis including the jaw bones. However, it remains unclear whether estrogen deficiency can affect the tooth mineralization. In this study, the classical osteoporotic rat model was established via the ovariectomy, which was subsequently confirmed by the detection of serum estradiol levels and body weights. The mineralization-related assays were performed to observe the potential changes in mineralized tissues of rat lower incisors. The clinical crown length, compressive strength, radiodensity, and calcium content in the ovariectomy group (OVX) were significantly downregulated (<italic>P</italic> < 0.01), as compared with the sham operation group (Sham). Histological results revealed that OVX incisors presented the thinner predentin structures than Sham incisors. Immunohistochemical staining and western blot assay further demonstrated that the odonto/osteoblast specific proteins (e.g., dentin sialoprotein, runt-related transcription factor 2, osterix, and osteocalcin) in the dentin–pulp complex of OVX incisors were significantly decreased in comparison with Sham counterparts. Together, estrogen deficiency reduces the dentinogenic capacity and calcium deposition in rat incisors, indicating that estrogen plays an important role in the dentinogenesis.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Bernick, S" uniqKey="Bernick S">S Bernick</name></author><author><name sortKey="Ershoff, Bh" uniqKey="Ershoff B">BH Ershoff</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bollen, Am" uniqKey="Bollen A">AM Bollen</name></author><author><name sortKey="Taguchi, A" uniqKey="Taguchi A">A Taguchi</name></author><author><name sortKey="Hujoel, Pp" uniqKey="Hujoel P">PP Hujoel</name></author><author><name sortKey="Hollender, Lg" uniqKey="Hollender L">LG Hollender</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Brennan, O" uniqKey="Brennan O">O Brennan</name></author><author><name sortKey="Kennedy, Od" uniqKey="Kennedy O">OD 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<front><journal-meta><journal-id journal-id-type="nlm-ta">J Mol Histol</journal-id><journal-id journal-id-type="iso-abbrev">J. Mol. Histol</journal-id><journal-title-group><journal-title>Journal of Molecular Histology</journal-title></journal-title-group><issn pub-type="ppub">1567-2379</issn><issn pub-type="epub">1567-2387</issn><publisher><publisher-name>Springer Netherlands</publisher-name><publisher-loc>Dordrecht</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">23974864</article-id><article-id pub-id-type="pmc">4544579</article-id><article-id pub-id-type="publisher-id">9533</article-id><article-id pub-id-type="doi">10.1007/s10735-013-9533-4</article-id><article-categories><subj-group subj-group-type="heading"><subject>Original Paper</subject></subj-group></article-categories><title-group><article-title>Estrogen deficiency reduces the dentinogenic capacity of rat lower incisors</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Xu</surname><given-names>Tao</given-names></name><xref ref-type="aff" rid="Aff1"></xref><xref ref-type="aff" rid="Aff2"></xref></contrib><contrib contrib-type="author"><name><surname>Yan</surname><given-names>Ming</given-names></name><xref ref-type="aff" rid="Aff1"></xref><xref ref-type="aff" rid="Aff3"></xref></contrib><contrib contrib-type="author"><name><surname>Wang</surname><given-names>Yanping</given-names></name><xref ref-type="aff" rid="Aff1"></xref><xref ref-type="aff" rid="Aff4"></xref></contrib><contrib contrib-type="author"><name><surname>Wang</surname><given-names>Zhanwei</given-names></name><xref ref-type="aff" rid="Aff5"></xref></contrib><contrib contrib-type="author"><name><surname>Xie</surname><given-names>Lizhe</given-names></name><xref ref-type="aff" rid="Aff1"></xref></contrib><contrib contrib-type="author"><name><surname>Tang</surname><given-names>Chunbo</given-names></name><xref ref-type="aff" rid="Aff1"></xref><xref ref-type="aff" rid="Aff6"></xref></contrib><contrib contrib-type="author"><name><surname>Zhang</surname><given-names>Guangdong</given-names></name><xref ref-type="aff" rid="Aff1"></xref><xref ref-type="aff" rid="Aff3"></xref></contrib><contrib contrib-type="author" corresp="yes"><name><surname>Yu</surname><given-names>Jinhua</given-names></name><address><phone>+86-25-86862843</phone><fax>+86-25-85031861</fax><email>yuziyi_yjh@hotmail.com</email><email>yuziyi_yjh@sohu.com</email></address><xref ref-type="aff" rid="Aff1"></xref><xref ref-type="aff" rid="Aff3"></xref></contrib><aff id="Aff1"><label></label>Institute of Stomatology, Nanjing Medical University, 140 Hanzhong Road, Nanjing, 210029 Jiangsu China</aff><aff id="Aff2"><label></label>Department of Stomatology, Nanjing Governmental Hospital, 116 Chengxian Road, Nanjing, 210018 Jiangsu China</aff><aff id="Aff3"><label></label>Department of Endodontics, School of Stomatology, Nanjing Medical University, 136 Hanzhong Road, Nanjing, 210029 Jiangsu China</aff><aff id="Aff4"><label></label>Department of Endodontics, Suzhou Stomatological Hospital, 1505 Renmin Road, Suzhou, 215005 Jiangsu China</aff><aff id="Aff5"><label></label>Cancer Biology Program, University of Hawaii Cancer Center, 701 Ilalo Street, Honolulu, HI 96813 USA</aff><aff id="Aff6"><label></label>Department of Prosthodontics, School of Stomatology, Nanjing Medical University, 136 Hanzhong Road, Nanjing, 210029 Jiangsu China</aff></contrib-group><pub-date pub-type="epub"><day>22</day><month>8</month><year>2013</year></pub-date><pub-date pub-type="pmc-release"><day>22</day><month>8</month><year>2013</year></pub-date><pub-date pub-type="ppub"><year>2014</year></pub-date><volume>45</volume><issue>1</issue><fpage>11</fpage><lpage>19</lpage><history><date date-type="received"><day>23</day><month>6</month><year>2013</year></date><date date-type="accepted"><day>12</day><month>8</month><year>2013</year></date></history><permissions><copyright-statement>© The Author(s) 2013</copyright-statement><license license-type="OpenAccess"><license-p><bold>Open Access</bold>This article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited.</license-p></license></permissions><abstract id="Abs1"><p>Endogenous estrogen deficiency usually causes the systemic osteoporosis including the jaw bones. However, it remains unclear whether estrogen deficiency can affect the tooth mineralization. In this study, the classical osteoporotic rat model was established via the ovariectomy, which was subsequently confirmed by the detection of serum estradiol levels and body weights. The mineralization-related assays were performed to observe the potential changes in mineralized tissues of rat lower incisors. The clinical crown length, compressive strength, radiodensity, and calcium content in the ovariectomy group (OVX) were significantly downregulated (<italic>P</italic> < 0.01), as compared with the sham operation group (Sham). Histological results revealed that OVX incisors presented the thinner predentin structures than Sham incisors. Immunohistochemical staining and western blot assay further demonstrated that the odonto/osteoblast specific proteins (e.g., dentin sialoprotein, runt-related transcription factor 2, osterix, and osteocalcin) in the dentin–pulp complex of OVX incisors were significantly decreased in comparison with Sham counterparts. Together, estrogen deficiency reduces the dentinogenic capacity and calcium deposition in rat incisors, indicating that estrogen plays an important role in the dentinogenesis.</p></abstract><kwd-group xml:lang="en"><title>Keywords</title><kwd>Ovariectomy</kwd><kwd>Estrogen</kwd><kwd>Tooth</kwd><kwd>Dentinogenesis</kwd><kwd>Mineralization</kwd></kwd-group><custom-meta-group><custom-meta><meta-name>issue-copyright-statement</meta-name><meta-value>© Springer Science+Business Media Dordrecht 2014</meta-value></custom-meta></custom-meta-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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