β-TCP/HA with or without enamel matrix proteins for maxillary sinus floor augmentation: a histomorphometric analysis of human biopsies
Identifieur interne : 000C94 ( Pmc/Curation ); précédent : 000C93; suivant : 000C95β-TCP/HA with or without enamel matrix proteins for maxillary sinus floor augmentation: a histomorphometric analysis of human biopsies
Auteurs : James Carlos Nery ; Luís Antônio Violin Dias Pereira ; George Furtado Guimarães ; Cassio Rocha Scardueli [Danemark] ; Fabiana Mantovani Gomes França ; Rubens Spin-Neto [Danemark] ; Andreas Stavropoulos [Suède]Source :
- International Journal of Implant Dentistry [ 2198-4034 ] ; 2017.
Abstract
It is still unclear whether enamel matrix proteins (EMD) as adjunct to bone grafting enhance bone healing. This study compared histomorphometrically maxillary sinus floor augmentation (MSFA) with β-TCP/HA in combination with or without EMD in humans.
In ten systemically healthy patients needing bilateral MSFA, one side was randomly treated using β-TCP/HA mixed with EMD (BC + EMD) and the other side using only β-TCP/HA (BC). After 6 months, biopsies were harvested from grafted areas during implant installation, being histologically and histomorphometrically analyzed. Differences between the groups considering new bone formation, soft tissues, and remaining BC were statistically evaluated.
All patients showed uneventful healing after MSFA, and dental implant installation was possible in all patients after 6 months. Histological analysis showed newly formed bone that was primarily woven in nature; it was organized in thin trabeculae, and it was occasionally in contact with residual bone substitute particles, which appeared in various forms and sizes and in advanced stage of degradation. Mean bone area was 43.4% (CI95 38.9; 47.8) for the BC group and 43.0% (CI95 36.6; 49.5) for the BC + EMD group. Mean soft tissue area was 21.3% (CI95 16.5; 26.2) for BC group and 21.5% (CI95 17.7; 25.3) for BC + EMD group, while the remaining biomaterial was 35.3% (CI95 36.6; 49.5) and 35.5% (CI95 29.6; 41.3) for BC and BC + EMD group, respectively.
MSFA with BC resulted in adequate amounts of new bone formation allowing successful implant installation; adding EMD did not have a significant effect.
Url:
DOI: 10.1186/s40729-017-0080-8
PubMed: 28474322
PubMed Central: 5418178
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James Carlos Nery<affiliation><nlm:aff id="Aff1">Department of Implantology, São Leopoldo Mandic Research Center, Brasília, DF Brazil</nlm:aff>
<wicri:noCountry code="subfield">DF Brazil</wicri:noCountry>
</affiliation>
<affiliation><nlm:aff id="Aff6">Implant Center, SEPS 710/910, Lotes CD, Office 226, CEP: 70390-108 Brasília, DF Brazil</nlm:aff>
<wicri:noCountry code="subfield">DF Brazil</wicri:noCountry>
</affiliation>
<affiliation><nlm:aff id="Aff6">Implant Center, SEPS 710/910, Lotes CD, Office 226, CEP: 70390-108 Brasília, DF Brazil</nlm:aff>
<wicri:noCountry code="subfield">DF Brazil</wicri:noCountry>
</affiliation>
<affiliation><nlm:aff id="Aff2">Department of Biochemistry and Tissue Biology, UNICAMP – State University of Campinas, Institute of Biology, Campinas, São Paulo Brazil</nlm:aff>
<wicri:noCountry code="subfield">São Paulo Brazil</wicri:noCountry>
</affiliation>
<affiliation><nlm:aff id="Aff1">Department of Implantology, São Leopoldo Mandic Research Center, Brasília, DF Brazil</nlm:aff>
<wicri:noCountry code="subfield">DF Brazil</wicri:noCountry>
</affiliation>
<affiliation><nlm:aff id="Aff3">Department of Periodontology, UNESP – Univ. Estadual Paulista, Araraquara Dental School, Araraquara, São Paulo Brazil</nlm:aff>
<wicri:noCountry code="subfield">São Paulo Brazil</wicri:noCountry>
</affiliation>
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Aarhus, Denmark</nlm:aff>
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<series><title level="j">International Journal of Implant Dentistry</title>
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<front><div type="abstract" xml:lang="en"><sec><title>Background</title>
<p>It is still unclear whether enamel matrix proteins (EMD) as adjunct to bone grafting enhance bone healing. This study compared histomorphometrically maxillary sinus floor augmentation (MSFA) with β-TCP/HA in combination with or without EMD in humans.</p>
</sec>
<sec><title>Methods</title>
<p>In ten systemically healthy patients needing bilateral MSFA, one side was randomly treated using β-TCP/HA mixed with EMD (BC + EMD) and the other side using only β-TCP/HA (BC). After 6 months, biopsies were harvested from grafted areas during implant installation, being histologically and histomorphometrically analyzed. Differences between the groups considering new bone formation, soft tissues, and remaining BC were statistically evaluated.</p>
</sec>
<sec><title>Results</title>
<p>All patients showed uneventful healing after MSFA, and dental implant installation was possible in all patients after 6 months. Histological analysis showed newly formed bone that was primarily woven in nature; it was organized in thin trabeculae, and it was occasionally in contact with residual bone substitute particles, which appeared in various forms and sizes and in advanced stage of degradation. Mean bone area was 43.4% (CI95 38.9; 47.8) for the BC group and 43.0% (CI95 36.6; 49.5) for the BC + EMD group. Mean soft tissue area was 21.3% (CI95 16.5; 26.2) for BC group and 21.5% (CI95 17.7; 25.3) for BC + EMD group, while the remaining biomaterial was 35.3% (CI95 36.6; 49.5) and 35.5% (CI95 29.6; 41.3) for BC and BC + EMD group, respectively.</p>
</sec>
<sec><title>Conclusions</title>
<p>MSFA with BC resulted in adequate amounts of new bone formation allowing successful implant installation; adding EMD did not have a significant effect.</p>
</sec>
</div>
</front>
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<pmc article-type="research-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Int J Implant Dent</journal-id>
<journal-id journal-id-type="iso-abbrev">Int J Implant Dent</journal-id>
<journal-title-group><journal-title>International Journal of Implant Dentistry</journal-title>
</journal-title-group>
<issn pub-type="epub">2198-4034</issn>
<publisher><publisher-name>Springer Berlin Heidelberg</publisher-name>
<publisher-loc>Berlin/Heidelberg</publisher-loc>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">28474322</article-id>
<article-id pub-id-type="pmc">5418178</article-id>
<article-id pub-id-type="publisher-id">80</article-id>
<article-id pub-id-type="doi">10.1186/s40729-017-0080-8</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Research</subject>
</subj-group>
</article-categories>
<title-group><article-title>β-TCP/HA with or without enamel matrix proteins for maxillary sinus floor augmentation: a histomorphometric analysis of human biopsies</article-title>
</title-group>
<contrib-group><contrib contrib-type="author" corresp="yes"><name><surname>Nery</surname>
<given-names>James Carlos</given-names>
</name>
<address><email>jamescnery@gmail.com</email>
</address>
<xref ref-type="aff" rid="Aff1">1</xref>
<xref ref-type="aff" rid="Aff6">6</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Pereira</surname>
<given-names>Luís Antônio Violin Dias</given-names>
</name>
<xref ref-type="aff" rid="Aff2">2</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Guimarães</surname>
<given-names>George Furtado</given-names>
</name>
<xref ref-type="aff" rid="Aff1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Scardueli</surname>
<given-names>Cassio Rocha</given-names>
</name>
<xref ref-type="aff" rid="Aff3">3</xref>
<xref ref-type="aff" rid="Aff4">4</xref>
</contrib>
<contrib contrib-type="author"><name><surname>França</surname>
<given-names>Fabiana Mantovani Gomes</given-names>
</name>
<xref ref-type="aff" rid="Aff1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Spin-Neto</surname>
<given-names>Rubens</given-names>
</name>
<xref ref-type="aff" rid="Aff4">4</xref>
</contrib>
<contrib contrib-type="author"><contrib-id contrib-id-type="orcid">http://orcid.org/0000-0001-8161-3754</contrib-id>
<name><surname>Stavropoulos</surname>
<given-names>Andreas</given-names>
</name>
<xref ref-type="aff" rid="Aff5">5</xref>
</contrib>
<aff id="Aff1"><label>1</label>
Department of Implantology, São Leopoldo Mandic Research Center, Brasília, DF Brazil</aff>
<aff id="Aff2"><label>2</label>
Department of Biochemistry and Tissue Biology, UNICAMP – State University of Campinas, Institute of Biology, Campinas, São Paulo Brazil</aff>
<aff id="Aff3"><label>3</label>
Department of Periodontology, UNESP – Univ. Estadual Paulista, Araraquara Dental School, Araraquara, São Paulo Brazil</aff>
<aff id="Aff4"><label>4</label>
<institution-wrap><institution-id institution-id-type="ISNI">0000 0001 1956 2722</institution-id>
<institution-id institution-id-type="GRID">grid.7048.b</institution-id>
<institution>Department of Dentistry and Oral Health – Oral Radiology,</institution>
<institution>Aarhus University,</institution>
</institution-wrap>
Aarhus, Denmark</aff>
<aff id="Aff5"><label>5</label>
<institution-wrap><institution-id institution-id-type="ISNI">0000 0000 9961 9487</institution-id>
<institution-id institution-id-type="GRID">grid.32995.34</institution-id>
<institution>Department Periodontology – Faculty of Odontology,</institution>
<institution>Malmö University,</institution>
</institution-wrap>
Malmö, Sweden</aff>
<aff id="Aff6"><label>6</label>
Implant Center, SEPS 710/910, Lotes CD, Office 226, CEP: 70390-108 Brasília, DF Brazil</aff>
</contrib-group>
<pub-date pub-type="epub"><day>4</day>
<month>5</month>
<year>2017</year>
</pub-date>
<pub-date pub-type="pmc-release"><day>4</day>
<month>5</month>
<year>2017</year>
</pub-date>
<pub-date pub-type="collection"><month>12</month>
<year>2017</year>
</pub-date>
<volume>3</volume>
<elocation-id>18</elocation-id>
<history><date date-type="received"><day>8</day>
<month>12</month>
<year>2016</year>
</date>
<date date-type="accepted"><day>22</day>
<month>4</month>
<year>2017</year>
</date>
</history>
<permissions><copyright-statement>© The Author(s). 2017</copyright-statement>
<license license-type="OpenAccess"><license-p><bold>Open Access</bold>
This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (<ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by/4.0/">http://creativecommons.org/licenses/by/4.0/</ext-link>
), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.</license-p>
</license>
</permissions>
<abstract id="Abs1"><sec><title>Background</title>
<p>It is still unclear whether enamel matrix proteins (EMD) as adjunct to bone grafting enhance bone healing. This study compared histomorphometrically maxillary sinus floor augmentation (MSFA) with β-TCP/HA in combination with or without EMD in humans.</p>
</sec>
<sec><title>Methods</title>
<p>In ten systemically healthy patients needing bilateral MSFA, one side was randomly treated using β-TCP/HA mixed with EMD (BC + EMD) and the other side using only β-TCP/HA (BC). After 6 months, biopsies were harvested from grafted areas during implant installation, being histologically and histomorphometrically analyzed. Differences between the groups considering new bone formation, soft tissues, and remaining BC were statistically evaluated.</p>
</sec>
<sec><title>Results</title>
<p>All patients showed uneventful healing after MSFA, and dental implant installation was possible in all patients after 6 months. Histological analysis showed newly formed bone that was primarily woven in nature; it was organized in thin trabeculae, and it was occasionally in contact with residual bone substitute particles, which appeared in various forms and sizes and in advanced stage of degradation. Mean bone area was 43.4% (CI95 38.9; 47.8) for the BC group and 43.0% (CI95 36.6; 49.5) for the BC + EMD group. Mean soft tissue area was 21.3% (CI95 16.5; 26.2) for BC group and 21.5% (CI95 17.7; 25.3) for BC + EMD group, while the remaining biomaterial was 35.3% (CI95 36.6; 49.5) and 35.5% (CI95 29.6; 41.3) for BC and BC + EMD group, respectively.</p>
</sec>
<sec><title>Conclusions</title>
<p>MSFA with BC resulted in adequate amounts of new bone formation allowing successful implant installation; adding EMD did not have a significant effect.</p>
</sec>
</abstract>
<kwd-group xml:lang="en"><title>Keywords</title>
<kwd>Bone substitute</kwd>
<kwd>Maxillary sinus floor</kwd>
<kwd>Enamel matrix proteins</kwd>
<kwd>Histomorphometry</kwd>
<kwd>Human</kwd>
</kwd-group>
<custom-meta-group><custom-meta><meta-name>issue-copyright-statement</meta-name>
<meta-value>© The Author(s) 2017</meta-value>
</custom-meta>
</custom-meta-group>
</article-meta>
</front>
</pmc>
</record>
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