Clinical efficacy of early loading versus conventional loading of dental implants
Identifieur interne : 000826 ( Pmc/Curation ); précédent : 000825; suivant : 000827Clinical efficacy of early loading versus conventional loading of dental implants
Auteurs : Yanfei Zhu [République populaire de Chine] ; Xinyi Zheng [République populaire de Chine] ; Guanqi Zeng [République populaire de Chine] ; Yi Xu [République populaire de Chine] ; Xinhua Qu [République populaire de Chine] ; Min Zhu [République populaire de Chine] ; Eryi Lu [République populaire de Chine]Source :
- Scientific Reports [ 2045-2322 ] ; 2015.
Abstract
The aim of this study was to determine the clinical differences between early and conventional loading protocols for dental implants. A comprehensive search of the Medline, Embase, and OVID databases for studies published through January 10, 2015 was conducted. Fourteen studies were included in our analysis. We found that early loading imposed a significantly higher risk of implant failure than did conventional loading (risk ratio = 2.09, 95% confidence interval [CI] [1.18, 3.69], P = 0.01), while no significant differences between the methods were found with regards to the marginal bone loss (weighted mean differences [WMD] = 0.11, 95% CI [−0.07, 0.28], P = 0.23), periotest value (WMD = 0.02, 95% CI [−0.83, 0.87], P = 0.96), or implant stability quotient (WMD = 0.79, 95% CI [−0.03, 1.62], P = 0.06). As for the health status of the peri-implant tissue, conventionally loaded implants demonstrated better performance than did early loaded implants. Subgroup analyses demonstrated that the sample size, time of publication, loading definition, implant position, extent, and restoration type influenced the results. Although early implant loading is convenient and comfortable for patients, this method still cannot achieve the same clinical outcomes as the conventional loading method.
Url:
DOI: 10.1038/srep15995
PubMed: 26542097
PubMed Central: 4635353
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Clinical efficacy of early loading versus conventional loading of dental implants</title><author><name sortKey="Zhu, Yanfei" sort="Zhu, Yanfei" uniqKey="Zhu Y" first="Yanfei" last="Zhu">Yanfei Zhu</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>College of Stomatology, Shanghai JiaoTong University School of Medicine</institution>, Shanghai,<country>China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Zheng, Xinyi" sort="Zheng, Xinyi" uniqKey="Zheng X" first="Xinyi" last="Zheng">Xinyi Zheng</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>College of Stomatology, Shanghai JiaoTong University School of Medicine</institution>, Shanghai,<country>China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Zeng, Guanqi" sort="Zeng, Guanqi" uniqKey="Zeng G" first="Guanqi" last="Zeng">Guanqi Zeng</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>College of Stomatology, Shanghai JiaoTong University School of Medicine</institution>, Shanghai,<country>China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Xu, Yi" sort="Xu, Yi" uniqKey="Xu Y" first="Yi" last="Xu">Yi Xu</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>College of Stomatology, Shanghai JiaoTong University School of Medicine</institution>, Shanghai,<country>China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Qu, Xinhua" sort="Qu, Xinhua" uniqKey="Qu X" first="Xinhua" last="Qu">Xinhua Qu</name><affiliation wicri:level="1"><nlm:aff id="a2"><institution>Department of Orthopaedics, Shanghai Ninth People’s Hospital, Shanghai JiaoTong University School of Medicine, Shanghai Key Laboratory of Orthopaedic Implant</institution>, Shanghai,<country>China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Zhu, Min" sort="Zhu, Min" uniqKey="Zhu M" first="Min" last="Zhu">Min Zhu</name><affiliation wicri:level="1"><nlm:aff id="a3"><institution>Department of Oral and Cranio-Maxillofacial Science, Shanghai Ninth People’s Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Stomatology</institution>, Shanghai,<country>China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Lu, Eryi" sort="Lu, Eryi" uniqKey="Lu E" first="Eryi" last="Lu">Eryi Lu</name><affiliation wicri:level="1"><nlm:aff id="a4"><institution>Department of Prosthodontics, Shanghai Ninth People’s Hospital, College of Stomatology, Shanghai JiaoTong University School of Medicine</institution>, Shanghai,<country>China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">26542097</idno><idno type="pmc">4635353</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4635353</idno><idno type="RBID">PMC:4635353</idno><idno type="doi">10.1038/srep15995</idno><date when="2015">2015</date><idno type="wicri:Area/Pmc/Corpus">000826</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" 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Stomatology, Shanghai JiaoTong University School of Medicine</institution>, Shanghai,<country>China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Zeng, Guanqi" sort="Zeng, Guanqi" uniqKey="Zeng G" first="Guanqi" last="Zeng">Guanqi Zeng</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>College of Stomatology, Shanghai JiaoTong University School of Medicine</institution>, Shanghai,<country>China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Xu, Yi" sort="Xu, Yi" uniqKey="Xu Y" first="Yi" last="Xu">Yi Xu</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>College of Stomatology, Shanghai JiaoTong University School of Medicine</institution>, Shanghai,<country>China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Qu, Xinhua" sort="Qu, Xinhua" uniqKey="Qu X" first="Xinhua" last="Qu">Xinhua Qu</name><affiliation wicri:level="1"><nlm:aff id="a2"><institution>Department of Orthopaedics, Shanghai Ninth People’s Hospital, Shanghai JiaoTong University School of Medicine, Shanghai Key Laboratory of Orthopaedic Implant</institution>, Shanghai,<country>China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Zhu, Min" sort="Zhu, Min" uniqKey="Zhu M" first="Min" last="Zhu">Min Zhu</name><affiliation wicri:level="1"><nlm:aff id="a3"><institution>Department of Oral and Cranio-Maxillofacial Science, Shanghai Ninth People’s Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Stomatology</institution>, Shanghai,<country>China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Lu, Eryi" sort="Lu, Eryi" uniqKey="Lu E" first="Eryi" last="Lu">Eryi Lu</name><affiliation wicri:level="1"><nlm:aff id="a4"><institution>Department of Prosthodontics, Shanghai Ninth People’s Hospital, College of Stomatology, Shanghai JiaoTong University School of Medicine</institution>, Shanghai,<country>China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></analytic><series><title level="j">Scientific Reports</title><idno type="eISSN">2045-2322</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>The aim of this study was to determine the clinical differences between early and conventional loading protocols for dental implants. A comprehensive search of the Medline, Embase, and OVID databases for studies published through January 10, 2015 was conducted. Fourteen studies were included in our analysis. We found that early loading imposed a significantly higher risk of implant failure than did conventional loading (risk ratio = 2.09, 95% confidence interval [CI] [1.18, 3.69], P = 0.01), while no significant differences between the methods were found with regards to the marginal bone loss (weighted mean differences [WMD] = 0.11, 95% CI [−0.07, 0.28], P = 0.23), periotest value (WMD = 0.02, 95% CI [−0.83, 0.87], P = 0.96), or implant stability quotient (WMD = 0.79, 95% CI [−0.03, 1.62], P = 0.06). As for the health status of the peri-implant tissue, conventionally loaded implants demonstrated better performance than did early loaded implants. Subgroup analyses demonstrated that the sample size, time of publication, loading definition, implant position, extent, and restoration type influenced the results. Although early implant loading is convenient and comfortable for patients, this method still cannot achieve the same clinical outcomes as the conventional loading method.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Branemark, P I" uniqKey="Branemark P">P. I. Branemark</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Branemark, P I" uniqKey="Branemark P">P. I. Branemark</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Schatzker, J" uniqKey="Schatzker J">J. Schatzker</name></author><author><name sortKey="Horne, J G" uniqKey="Horne J">J. G. Horne</name></author><author><name sortKey="Sumner Smith, G" uniqKey="Sumner Smith G">G. Sumner-Smith</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Roberts, W E" uniqKey="Roberts W">W. E. Roberts</name></author><author><name sortKey="Smith, R K" uniqKey="Smith R">R. K. 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<front><journal-meta><journal-id journal-id-type="nlm-ta">Sci Rep</journal-id><journal-id journal-id-type="iso-abbrev">Sci Rep</journal-id><journal-title-group><journal-title>Scientific Reports</journal-title></journal-title-group><issn pub-type="epub">2045-2322</issn><publisher><publisher-name>Nature Publishing Group</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">26542097</article-id><article-id pub-id-type="pmc">4635353</article-id><article-id pub-id-type="pii">srep15995</article-id><article-id pub-id-type="doi">10.1038/srep15995</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Clinical efficacy of early loading versus conventional loading of dental implants</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Zhu</surname><given-names>Yanfei</given-names></name><xref ref-type="aff" rid="a1">1</xref><xref ref-type="author-notes" rid="n1">*</xref></contrib><contrib contrib-type="author"><name><surname>Zheng</surname><given-names>Xinyi</given-names></name><xref ref-type="aff" rid="a1">1</xref><xref ref-type="author-notes" rid="n1">*</xref></contrib><contrib contrib-type="author"><name><surname>Zeng</surname><given-names>Guanqi</given-names></name><xref ref-type="aff" rid="a1">1</xref></contrib><contrib contrib-type="author"><name><surname>Xu</surname><given-names>Yi</given-names></name><xref ref-type="aff" rid="a1">1</xref></contrib><contrib contrib-type="author"><name><surname>Qu</surname><given-names>Xinhua</given-names></name><xref ref-type="corresp" rid="c1">a</xref><xref ref-type="aff" rid="a2">2</xref></contrib><contrib contrib-type="author"><name><surname>Zhu</surname><given-names>Min</given-names></name><xref ref-type="corresp" rid="c2">b</xref><xref ref-type="aff" rid="a3">3</xref></contrib><contrib contrib-type="author"><name><surname>Lu</surname><given-names>Eryi</given-names></name><xref ref-type="corresp" rid="c3">c</xref><xref ref-type="aff" rid="a4">4</xref></contrib><aff id="a1"><label>1</label><institution>College of Stomatology, Shanghai JiaoTong University School of Medicine</institution>, Shanghai,<country>China</country></aff><aff id="a2"><label>2</label><institution>Department of Orthopaedics, Shanghai Ninth People’s Hospital, Shanghai JiaoTong University School of Medicine, Shanghai Key Laboratory of Orthopaedic Implant</institution>, Shanghai,<country>China</country></aff><aff id="a3"><label>3</label><institution>Department of Oral and Cranio-Maxillofacial Science, Shanghai Ninth People’s Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Stomatology</institution>, Shanghai,<country>China</country></aff><aff id="a4"><label>4</label><institution>Department of Prosthodontics, Shanghai Ninth People’s Hospital, College of Stomatology, Shanghai JiaoTong University School of Medicine</institution>, Shanghai,<country>China</country></aff></contrib-group><author-notes><corresp id="c1"><label>a</label><email>xinhua_qu@126.com</email></corresp><corresp id="c2"><label>b</label><email>zminnie@126.com</email></corresp><corresp id="c3"><label>c</label><email>lueryi222@126.com</email></corresp><fn id="n1"><label>*</label><p>These authors contributed equally to this work.</p></fn></author-notes><pub-date pub-type="epub"><day>06</day><month>11</month><year>2015</year></pub-date><pub-date pub-type="collection"><year>2015</year></pub-date><volume>5</volume><elocation-id>15995</elocation-id><history><date date-type="received"><day>03</day><month>07</month><year>2015</year></date><date date-type="accepted"><day>07</day><month>10</month><year>2015</year></date></history><permissions><copyright-statement>Copyright © 2015, Macmillan Publishers Limited</copyright-statement><copyright-year>2015</copyright-year><copyright-holder>Macmillan Publishers Limited</copyright-holder><license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by/4.0/"><pmc-comment>author-paid</pmc-comment>
<license-p>This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit <ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by/4.0/">http://creativecommons.org/licenses/by/4.0/</ext-link></license-p></license></permissions><abstract><p>The aim of this study was to determine the clinical differences between early and conventional loading protocols for dental implants. A comprehensive search of the Medline, Embase, and OVID databases for studies published through January 10, 2015 was conducted. Fourteen studies were included in our analysis. We found that early loading imposed a significantly higher risk of implant failure than did conventional loading (risk ratio = 2.09, 95% confidence interval [CI] [1.18, 3.69], P = 0.01), while no significant differences between the methods were found with regards to the marginal bone loss (weighted mean differences [WMD] = 0.11, 95% CI [−0.07, 0.28], P = 0.23), periotest value (WMD = 0.02, 95% CI [−0.83, 0.87], P = 0.96), or implant stability quotient (WMD = 0.79, 95% CI [−0.03, 1.62], P = 0.06). As for the health status of the peri-implant tissue, conventionally loaded implants demonstrated better performance than did early loaded implants. Subgroup analyses demonstrated that the sample size, time of publication, loading definition, implant position, extent, and restoration type influenced the results. Although early implant loading is convenient and comfortable for patients, this method still cannot achieve the same clinical outcomes as the conventional loading method.</p></abstract></article-meta></front><floats-group><fig id="f1"><label>Figure 1</label><caption><title>Flow-chart depicting the literature search procedure.</title></caption><graphic xlink:href="srep15995-f1"></graphic></fig><fig id="f2"><label>Figure 2</label><caption><title>Forrest plots of the individual studies for the implant failure rate.</title><p>Note that Tawse-Smith (2002) (test 1) and (test 2) indicate that in the same study, two controlled experiments were performed. Ma (2010) (test 1) and (test 2) indicate that in the same study, two different test groups were compared to the same control group.</p></caption><graphic xlink:href="srep15995-f2"></graphic></fig><fig id="f3"><label>Figure 3</label><caption><title>Forrest plots of the individual studies for the marginal bone loss.</title></caption><graphic xlink:href="srep15995-f3"></graphic></fig><fig id="f4"><label>Figure 4</label><caption><title>Forrest plots of the individual studies for the periotest value.</title></caption><graphic xlink:href="srep15995-f4"></graphic></fig><fig id="f5"><label>Figure 5</label><caption><title>Forrest plots of the individual studies for the implant stability quotient.</title></caption><graphic xlink:href="srep15995-f5"></graphic></fig><table-wrap position="float" id="t1"><label>Table 1</label><caption><title>Study characteristics.</title></caption><table frame="hsides" rules="groups" border="1"><colgroup><col align="left"></col><col align="center"></col><col align="center"></col><col align="center"></col><col align="center"></col><col align="center"></col><col align="center"></col></colgroup><thead valign="bottom"><tr><th align="left" valign="top" charoff="50">Author (Year)</th><th align="center" valign="top" charoff="50">Country</th><th align="center" valign="top" charoff="50">Study design</th><th align="center" valign="top" charoff="50">Follow-up</th><th align="center" valign="top" charoff="50">Mean age /range</th><th align="center" valign="top" charoff="50">Patients (Test/Control)</th><th align="center" valign="top" charoff="50">Implants (Test/Control)</th></tr></thead><tbody valign="top"><tr><td align="left" valign="top" charoff="50">Anil (2012)</td><td align="center" valign="top" charoff="50">India</td><td align="center" valign="top" charoff="50">Prospective clinical comparative study</td><td align="center" valign="top" charoff="50">6 months</td><td align="center" valign="top" charoff="50">45 ~ 65</td><td align="center" valign="top" charoff="50">5/5</td><td align="center" valign="top" charoff="50">10/10</td></tr><tr><td align="left" valign="top" charoff="50">Barewal (2012)</td><td align="center" valign="top" charoff="50">Poland</td><td align="center" valign="top" charoff="50">RCT</td><td align="center" valign="top" charoff="50">3 years</td><td align="center" valign="top" charoff="50">20 ~ 82</td><td align="center" valign="top" charoff="50">17/17</td><td align="center" valign="top" charoff="50">15/15</td></tr><tr><td align="left" valign="top" charoff="50">De Smet (2007)</td><td align="center" valign="top" charoff="50">Belgium</td><td align="center" valign="top" charoff="50">Prospective clinical comparative study</td><td align="center" valign="top" charoff="50">2 years</td><td align="center" valign="top" charoff="50">33 ~ 86</td><td align="center" valign="top" charoff="50">10/10</td><td align="center" valign="top" charoff="50">20/20</td></tr><tr><td align="left" valign="top" charoff="50">Ericsson (2000)</td><td align="center" valign="top" charoff="50">Sweden</td><td align="center" valign="top" charoff="50">Prospective clinical comparative study</td><td align="center" valign="top" charoff="50">5 years</td><td align="center" valign="top" charoff="50">66.3/53 ~ 77</td><td align="center" valign="top" charoff="50">16/11</td><td align="center" valign="top" charoff="50">88/30</td></tr><tr><td align="left" valign="top" charoff="50">Engquist (2005)</td><td align="center" valign="top" charoff="50">Sweden</td><td align="center" valign="top" charoff="50">Prospective clinical comparative study</td><td align="center" valign="top" charoff="50">3 years</td><td align="center" valign="top" charoff="50">64.9</td><td align="center" valign="top" charoff="50">26/30</td><td align="center" valign="top" charoff="50">108/120</td></tr><tr><td align="left" valign="top" charoff="50">Eliasson (2009)</td><td align="center" valign="top" charoff="50">Sweden</td><td align="center" valign="top" charoff="50">Retrospective clinical comparative study</td><td align="center" valign="top" charoff="50">5 years</td><td align="center" valign="top" charoff="50">47 ~ 90</td><td align="center" valign="top" charoff="50">55/54</td><td align="center" valign="top" charoff="50">248/242</td></tr><tr><td align="left" valign="top" charoff="50">Fischer (2008)</td><td align="center" valign="top" charoff="50">Sweden</td><td align="center" valign="top" charoff="50">RCT</td><td align="center" valign="top" charoff="50">5 years</td><td align="center" valign="top" charoff="50">39 ~ 79</td><td align="center" valign="top" charoff="50">16/8</td><td align="center" valign="top" charoff="50">95/47</td></tr><tr><td align="left" valign="top" charoff="50">Ma (2010) (test 1)</td><td align="center" valign="top" charoff="50">New Zealand</td><td align="center" valign="top" charoff="50">RCT</td><td align="center" valign="top" charoff="50">10 years</td><td align="center" valign="top" charoff="50">65</td><td align="center" valign="top" charoff="50">34/36</td><td align="center" valign="top" charoff="50">68/72</td></tr><tr><td align="left" valign="top" charoff="50">(test 2)</td><td align="center" valign="top" charoff="50"> </td><td align="center" valign="top" charoff="50"> </td><td align="center" valign="top" charoff="50"> </td><td align="center" valign="top" charoff="50"> </td><td align="center" valign="top" charoff="50">36/36</td><td align="center" valign="top" charoff="50">72/72</td></tr><tr><td align="left" valign="top" charoff="50">Payne (2002)</td><td align="center" valign="top" charoff="50">New Zealand</td><td align="center" valign="top" charoff="50">RCT</td><td align="center" valign="top" charoff="50">2 years</td><td align="center" valign="top" charoff="50">55 ~ 80</td><td align="center" valign="top" charoff="50">12/12</td><td align="center" valign="top" charoff="50">24/24</td></tr><tr><td align="left" valign="top" charoff="50">Røynesdal (2001)</td><td align="center" valign="top" charoff="50">Norway</td><td align="center" valign="top" charoff="50">Prospective clinical comparative study</td><td align="center" valign="top" charoff="50">2 years</td><td align="center" valign="top" charoff="50">75.7/61 ~ 85</td><td align="center" valign="top" charoff="50">11/10</td><td align="center" valign="top" charoff="50">22/20</td></tr><tr><td align="left" valign="top" charoff="50">Tawse-Smith (2002)</td><td align="center" valign="top" charoff="50">New Zealand</td><td align="center" valign="top" charoff="50">RCT</td><td align="center" valign="top" charoff="50">2 years</td><td align="center" valign="top" charoff="50">55 ~ 80</td><td align="center" valign="top" charoff="50">24/24</td><td align="center" valign="top" charoff="50">48/48</td></tr><tr><td align="left" valign="top" charoff="50">Turkyilmaz (2007a)</td><td align="center" valign="top" charoff="50">Turkey</td><td align="center" valign="top" charoff="50">Prospective clinical comparative study</td><td align="center" valign="top" charoff="50">4 years</td><td align="center" valign="top" charoff="50">40/20 ~ 60</td><td align="center" valign="top" charoff="50">19/10</td><td align="center" valign="top" charoff="50">36/23</td></tr><tr><td align="left" valign="top" charoff="50">Turkyilmaz (2007b)</td><td align="center" valign="top" charoff="50">Turkey</td><td align="center" valign="top" charoff="50">RCT</td><td align="center" valign="top" charoff="50">2 years</td><td align="center" valign="top" charoff="50">62</td><td align="center" valign="top" charoff="50">10/10</td><td align="center" valign="top" charoff="50">20/20</td></tr><tr><td align="left" valign="top" charoff="50">Turkyilmaz (2012)</td><td align="center" valign="top" charoff="50">Turkey</td><td align="center" valign="top" charoff="50">RCT</td><td align="center" valign="top" charoff="50">7 years</td><td align="center" valign="top" charoff="50">63</td><td align="center" valign="top" charoff="50">13/13</td><td align="center" valign="top" charoff="50">26/26</td></tr></tbody></table><table-wrap-foot><fn id="t1-fn1"><p>RCT = randomized controlled trial.</p></fn><fn id="t1-fn2"><p>Ma (2010) (test 1) and (test 2) mean that in the same study, two different test groups were compared to the same control group.</p></fn></table-wrap-foot></table-wrap><table-wrap position="float" id="t2"><label>Table 2</label><caption><title>Subgroup analysis to investigate differences between studies included in meta-analysis for failure rate.</title></caption><table frame="hsides" rules="groups" border="1"><colgroup><col align="left"></col><col align="center"></col><col align="center"></col><col align="center"></col><col align="center"></col><col align="center"></col><col align="center"></col></colgroup><thead valign="bottom"><tr><th align="left" valign="top" charoff="50">Analyses</th><th align="center" valign="top" charoff="50">Subgroup</th><th align="center" valign="top" charoff="50">Number of studies</th><th align="center" valign="top" charoff="50">RR [95% CI]</th><th align="center" valign="top" charoff="50">P value</th><th align="center" valign="top" charoff="50">I<sup>2</sup> (%)</th><th align="center" valign="top" charoff="50">P value for heterogeneity</th></tr></thead><tbody valign="top"><tr><td align="left" valign="top" charoff="50">Overall</td><td align="center" valign="top" charoff="50"> </td><td align="center" valign="top" charoff="50">14</td><td align="center" valign="top" charoff="50">2.09 [1.18, 3.69]</td><td align="center" valign="top" charoff="50">0.01</td><td align="center" valign="top" charoff="50">0%</td><td align="center" valign="top" charoff="50">0.63</td></tr><tr><td align="left" valign="top" charoff="50">Sample size (implant)</td><td align="center" valign="top" charoff="50">≤50</td><td align="center" valign="top" charoff="50">7</td><td align="center" valign="top" charoff="50">1.98 [0.68, 5.73]</td><td align="center" valign="top" charoff="50">0.21</td><td align="center" valign="top" charoff="50">40%</td><td align="center" valign="top" charoff="50">0.19</td></tr><tr><td align="left" valign="top" charoff="50"> </td><td align="center" valign="top" charoff="50">>50</td><td align="center" valign="top" charoff="50">7</td><td align="center" valign="top" charoff="50">2.13 [1.08, 4.19]</td><td align="center" valign="top" charoff="50">0.03</td><td align="center" valign="top" charoff="50">0%</td><td align="center" valign="top" charoff="50">0.82</td></tr><tr><td align="left" valign="top" charoff="50">Time of publication</td><td align="center" valign="top" charoff="50">Before 2007</td><td align="center" valign="top" charoff="50">8</td><td align="center" valign="top" charoff="50">2.57 [1.11, 5.94]</td><td align="center" valign="top" charoff="50">0.03</td><td align="center" valign="top" charoff="50">0%</td><td align="center" valign="top" charoff="50">0.52</td></tr><tr><td align="left" valign="top" charoff="50"> </td><td align="center" valign="top" charoff="50">After 2007</td><td align="center" valign="top" charoff="50">6</td><td align="center" valign="top" charoff="50">1.72 [0.78, 3.78]</td><td align="center" valign="top" charoff="50">0.18</td><td align="center" valign="top" charoff="50">0%</td><td align="center" valign="top" charoff="50">0.39</td></tr><tr><td align="left" valign="top" charoff="50">Definition of early</td><td align="center" valign="top" charoff="50">1 week</td><td align="center" valign="top" charoff="50">4</td><td align="center" valign="top" charoff="50">1.00 [0.17, 5.77]</td><td align="center" valign="top" charoff="50">1.00</td><td align="center" valign="top" charoff="50">/</td><td align="center" valign="top" charoff="50">/</td></tr><tr><td align="left" valign="top" charoff="50"> </td><td align="center" valign="top" charoff="50">3 weeks</td><td align="center" valign="top" charoff="50">4</td><td align="center" valign="top" charoff="50">2.60 [1.17, 5.79]</td><td align="center" valign="top" charoff="50">0.02</td><td align="center" valign="top" charoff="50">0%</td><td align="center" valign="top" charoff="50">0.87</td></tr><tr><td align="left" valign="top" charoff="50"> </td><td align="center" valign="top" charoff="50">6 weeks</td><td align="center" valign="top" charoff="50">4</td><td align="center" valign="top" charoff="50">2.72 [0.69, 10.77]</td><td align="center" valign="top" charoff="50">0.15</td><td align="center" valign="top" charoff="50">62%</td><td align="center" valign="top" charoff="50">0.11</td></tr><tr><td align="left" valign="top" charoff="50">Definition of conventional</td><td align="center" valign="top" charoff="50">≤3 months</td><td align="center" valign="top" charoff="50">8</td><td align="center" valign="top" charoff="50">2.78 [1.07, 7.22]</td><td align="center" valign="top" charoff="50">0.04</td><td align="center" valign="top" charoff="50">24%</td><td align="center" valign="top" charoff="50">0.27</td></tr><tr><td align="left" valign="top" charoff="50"> </td><td align="center" valign="top" charoff="50">>3 months</td><td align="center" valign="top" charoff="50">5</td><td align="center" valign="top" charoff="50">1.93 [0.86, 4.33]</td><td align="center" valign="top" charoff="50">0.11</td><td align="center" valign="top" charoff="50">0%</td><td align="center" valign="top" charoff="50">0.64</td></tr><tr><td align="left" valign="top" charoff="50">Extent of restoration</td><td align="center" valign="top" charoff="50">Full-arch</td><td align="center" valign="top" charoff="50">12</td><td align="center" valign="top" charoff="50">2.37 [1.28, 4.39]</td><td align="center" valign="top" charoff="50">0.006</td><td align="center" valign="top" charoff="50">0%</td><td align="center" valign="top" charoff="50">0.62</td></tr><tr><td align="left" valign="top" charoff="50"> </td><td align="center" valign="top" charoff="50">Single</td><td align="center" valign="top" charoff="50">2</td><td align="center" valign="top" charoff="50">0.72 [0.12, 4.22]</td><td align="center" valign="top" charoff="50">0.72</td><td align="center" valign="top" charoff="50">0%</td><td align="center" valign="top" charoff="50">0.46</td></tr><tr><td align="left" valign="top" charoff="50">Position of implants</td><td align="center" valign="top" charoff="50">Maxilla</td><td align="center" valign="top" charoff="50">2</td><td align="center" valign="top" charoff="50">1.22 [0.33, 4.58]</td><td align="center" valign="top" charoff="50">0.77</td><td align="center" valign="top" charoff="50">0%</td><td align="center" valign="top" charoff="50">0.96</td></tr><tr><td align="left" valign="top" charoff="50"> </td><td align="center" valign="top" charoff="50">Mandibular</td><td align="center" valign="top" charoff="50">11</td><td align="center" valign="top" charoff="50">2.67 [1.36, 5.24]</td><td align="center" valign="top" charoff="50">0.004</td><td align="center" valign="top" charoff="50">0%</td><td align="center" valign="top" charoff="50">0.58</td></tr><tr><td align="left" valign="top" charoff="50">Type of restoration</td><td align="center" valign="top" charoff="50">Fixed</td><td align="center" valign="top" charoff="50">6</td><td align="center" valign="top" charoff="50">1.91 [1.00, 3.64]</td><td align="center" valign="top" charoff="50">0.05</td><td align="center" valign="top" charoff="50">0%</td><td align="center" valign="top" charoff="50">0.66</td></tr><tr><td align="left" valign="top" charoff="50"> </td><td align="center" valign="top" charoff="50">Removable</td><td align="center" valign="top" charoff="50">8</td><td align="center" valign="top" charoff="50">2.86 [0.83, 9.86]</td><td align="center" valign="top" charoff="50">0.10</td><td align="center" valign="top" charoff="50">50%</td><td align="center" valign="top" charoff="50">0.16</td></tr></tbody></table></table-wrap><table-wrap position="float" id="t3"><label>Table 3</label><caption><title>Subgroup analysis to investigate differences between studies included in meta-analysis for MBL (mm).</title></caption><table frame="hsides" rules="groups" border="1"><colgroup><col align="left"></col><col align="center"></col><col align="center"></col><col align="center"></col><col align="center"></col><col align="center"></col><col align="center"></col></colgroup><thead valign="bottom"><tr><th align="left" valign="top" charoff="50">Analyses</th><th align="center" valign="top" charoff="50">Subgroup</th><th align="center" valign="top" charoff="50">Number of Studies</th><th align="center" valign="top" charoff="50">WMD [95% CI]</th><th align="center" valign="top" charoff="50">P value</th><th align="center" valign="top" charoff="50">I<sup>2</sup> (%)</th><th align="center" valign="top" charoff="50">P value for heterogeneity</th></tr></thead><tbody valign="top"><tr><td align="left" valign="top" charoff="50">Overall</td><td align="center" valign="top" charoff="50"> </td><td align="center" valign="top" charoff="50">11</td><td align="center" valign="top" charoff="50">0.11 [−0.07, 0.28]</td><td align="center" valign="top" charoff="50">0.23</td><td align="center" valign="top" charoff="50">97%</td><td align="center" valign="top" charoff="50"><0.01</td></tr><tr><td align="left" valign="top" charoff="50">≤1 year</td><td align="center" valign="top" charoff="50"> </td><td align="center" valign="top" charoff="50">7</td><td align="center" valign="top" charoff="50">0.18 [−0.00, 0.35]</td><td align="center" valign="top" charoff="50">0.05</td><td align="center" valign="top" charoff="50">98%</td><td align="center" valign="top" charoff="50"><0.01</td></tr><tr><td align="left" valign="top" charoff="50">2 ~ 3 years</td><td align="center" valign="top" charoff="50"> </td><td align="center" valign="top" charoff="50">5</td><td align="center" valign="top" charoff="50">0.26 [−0.15, 0.68]</td><td align="center" valign="top" charoff="50">0.21</td><td align="center" valign="top" charoff="50">96%</td><td align="center" valign="top" charoff="50"><0.01</td></tr><tr><td align="left" valign="top" charoff="50">≥5 years</td><td align="center" valign="top" charoff="50"> </td><td align="center" valign="top" charoff="50">3</td><td align="center" valign="top" charoff="50">0.10 [−0.10, 0.29]</td><td align="center" valign="top" charoff="50">0.33</td><td align="center" valign="top" charoff="50">77%</td><td align="center" valign="top" charoff="50"><0.01</td></tr><tr><td align="left" valign="top" charoff="50">Length of follow-up</td><td align="center" valign="top" charoff="50">≤1 years</td><td align="center" valign="top" charoff="50">5</td><td align="center" valign="top" charoff="50">0.09 [−0.13, 0.32]</td><td align="center" valign="top" charoff="50">0.42</td><td align="center" valign="top" charoff="50">97%</td><td align="center" valign="top" charoff="50"><0.01</td></tr><tr><td align="left" valign="top" charoff="50"> </td><td align="center" valign="top" charoff="50">2 ~ 3 years</td><td align="center" valign="top" charoff="50">3</td><td align="center" valign="top" charoff="50">0.11 [−0.52, 0.74]</td><td align="center" valign="top" charoff="50">0.74</td><td align="center" valign="top" charoff="50">98%</td><td align="center" valign="top" charoff="50"><0.01</td></tr><tr><td align="left" valign="top" charoff="50"> </td><td align="center" valign="top" charoff="50">≥5 years</td><td align="center" valign="top" charoff="50">3</td><td align="center" valign="top" charoff="50">0.10 [−0.10, 0.29]</td><td align="center" valign="top" charoff="50">0.33</td><td align="center" valign="top" charoff="50">77%</td><td align="center" valign="top" charoff="50"><0.01</td></tr><tr><td align="left" valign="top" charoff="50">Sample size (implant)</td><td align="center" valign="top" charoff="50">≤50</td><td align="center" valign="top" charoff="50">5</td><td align="center" valign="top" charoff="50">0.10 [−0.09, 0.29]</td><td align="center" valign="top" charoff="50">0.31</td><td align="center" valign="top" charoff="50">91%</td><td align="center" valign="top" charoff="50"><0.01</td></tr><tr><td align="left" valign="top" charoff="50"> </td><td align="center" valign="top" charoff="50">>50</td><td align="center" valign="top" charoff="50">6</td><td align="center" valign="top" charoff="50">0.11 [−0.15, 0.37]</td><td align="center" valign="top" charoff="50">0.39</td><td align="center" valign="top" charoff="50">97%</td><td align="center" valign="top" charoff="50"><0.01</td></tr><tr><td align="left" valign="top" charoff="50">Design of study</td><td align="center" valign="top" charoff="50">RCT</td><td align="center" valign="top" charoff="50">7</td><td align="center" valign="top" charoff="50">0.01 [−0.06, 0.07]</td><td align="center" valign="top" charoff="50">0.87</td><td align="center" valign="top" charoff="50">47%</td><td align="center" valign="top" charoff="50">0.06</td></tr><tr><td align="left" valign="top" charoff="50"> </td><td align="center" valign="top" charoff="50">Prospective study</td><td align="center" valign="top" charoff="50">3</td><td align="center" valign="top" charoff="50">0.23 [−0.29, 0.74]</td><td align="center" valign="top" charoff="50">0.39</td><td align="center" valign="top" charoff="50">98%</td><td align="center" valign="top" charoff="50"><0.01</td></tr><tr><td align="left" valign="top" charoff="50">Geographical location</td><td align="center" valign="top" charoff="50">Asia</td><td align="center" valign="top" charoff="50">2</td><td align="center" valign="top" charoff="50">−0.02 [−0.09, 0.06]</td><td align="center" valign="top" charoff="50">0.64</td><td align="center" valign="top" charoff="50">0%</td><td align="center" valign="top" charoff="50">0.60</td></tr><tr><td align="left" valign="top" charoff="50"> </td><td align="center" valign="top" charoff="50">Europe</td><td align="center" valign="top" charoff="50">6</td><td align="center" valign="top" charoff="50">0.23 [−0.05, 0.52]</td><td align="center" valign="top" charoff="50">0.1</td><td align="center" valign="top" charoff="50">96%</td><td align="center" valign="top" charoff="50"><0.01</td></tr><tr><td align="left" valign="top" charoff="50"> </td><td align="center" valign="top" charoff="50">Oceania</td><td align="center" valign="top" charoff="50">3</td><td align="center" valign="top" charoff="50">−0.01 [−0.10, 0.09]</td><td align="center" valign="top" charoff="50">0.89</td><td align="center" valign="top" charoff="50">51%</td><td align="center" valign="top" charoff="50">0.09</td></tr><tr><td align="left" valign="top" charoff="50">Time of publication</td><td align="center" valign="top" charoff="50">Before 2007</td><td align="center" valign="top" charoff="50">6</td><td align="center" valign="top" charoff="50">0.08 [−0.17, 0.33]</td><td align="center" valign="top" charoff="50">0.52</td><td align="center" valign="top" charoff="50">98%</td><td align="center" valign="top" charoff="50"><0.01</td></tr><tr><td align="left" valign="top" charoff="50"> </td><td align="center" valign="top" charoff="50">After 2007</td><td align="center" valign="top" charoff="50">5</td><td align="center" valign="top" charoff="50">0.11 [−0.03, 0.25]</td><td align="center" valign="top" charoff="50">0.23</td><td align="center" valign="top" charoff="50">97%</td><td align="center" valign="top" charoff="50"><0.01</td></tr><tr><td align="left" valign="top" charoff="50">Definition of early</td><td align="center" valign="top" charoff="50">1 week</td><td align="center" valign="top" charoff="50">3</td><td align="center" valign="top" charoff="50">0.21 [−0.16, 0.57]</td><td align="center" valign="top" charoff="50">0.27</td><td align="center" valign="top" charoff="50">96%</td><td align="center" valign="top" charoff="50"><0.01</td></tr><tr><td align="left" valign="top" charoff="50"> </td><td align="center" valign="top" charoff="50">3 week</td><td align="center" valign="top" charoff="50">3</td><td align="center" valign="top" charoff="50">0.08 [−0.39, 0.55]</td><td align="center" valign="top" charoff="50">0.73</td><td align="center" valign="top" charoff="50">98%</td><td align="center" valign="top" charoff="50"><0.01</td></tr><tr><td align="left" valign="top" charoff="50"> </td><td align="center" valign="top" charoff="50">6 week</td><td align="center" valign="top" charoff="50">4</td><td align="center" valign="top" charoff="50">−0.04 [−0.10, 0.03]</td><td align="center" valign="top" charoff="50">0.26</td><td align="center" valign="top" charoff="50">0%</td><td align="center" valign="top" charoff="50">0.72</td></tr><tr><td align="left" valign="top" charoff="50">Definition of conventional</td><td align="center" valign="top" charoff="50">≤3 months</td><td align="center" valign="top" charoff="50">7</td><td align="center" valign="top" charoff="50">0.08 [−0.11, 0.27]</td><td align="center" valign="top" charoff="50">0.41</td><td align="center" valign="top" charoff="50">96%</td><td align="center" valign="top" charoff="50"><0.01</td></tr><tr><td align="left" valign="top" charoff="50"> </td><td align="center" valign="top" charoff="50">>3 months</td><td align="center" valign="top" charoff="50">3</td><td align="center" valign="top" charoff="50">0.09 [−0.43, 0.61]</td><td align="center" valign="top" charoff="50">0.73</td><td align="center" valign="top" charoff="50">98%</td><td align="center" valign="top" charoff="50"><0.01</td></tr><tr><td align="left" valign="top" charoff="50">Extent of restoration</td><td align="center" valign="top" charoff="50">Full-arch</td><td align="center" valign="top" charoff="50">10</td><td align="center" valign="top" charoff="50">0.11 [−0.07, 0.29]</td><td align="center" valign="top" charoff="50">0.23</td><td align="center" valign="top" charoff="50">97%</td><td align="center" valign="top" charoff="50"><0.01</td></tr><tr><td align="left" valign="top" charoff="50"> </td><td align="center" valign="top" charoff="50">Single</td><td align="center" valign="top" charoff="50">1</td><td align="center" valign="top" charoff="50">0.04 [−0.14, 0.22]</td><td align="center" valign="top" charoff="50">0.66</td><td align="center" valign="top" charoff="50">/</td><td align="center" valign="top" charoff="50">/</td></tr><tr><td align="left" valign="top" charoff="50">Position of implants</td><td align="center" valign="top" charoff="50">Maxilla</td><td align="center" valign="top" charoff="50">1</td><td align="center" valign="top" charoff="50">0.50 [0.10, 0.90]</td><td align="center" valign="top" charoff="50">0.01</td><td align="center" valign="top" charoff="50">/</td><td align="center" valign="top" charoff="50">/</td></tr><tr><td align="left" valign="top" charoff="50"> </td><td align="center" valign="top" charoff="50">Mandibular</td><td align="center" valign="top" charoff="50">9</td><td align="center" valign="top" charoff="50">0.09 [−0.10, 0.27]</td><td align="center" valign="top" charoff="50">0.37</td><td align="center" valign="top" charoff="50">97%</td><td align="center" valign="top" charoff="50"><0.01</td></tr><tr><td align="left" valign="top" charoff="50">Type of restoration</td><td align="center" valign="top" charoff="50">Fixed</td><td align="center" valign="top" charoff="50">5</td><td align="center" valign="top" charoff="50">0.14 [−0.19, 0.48]</td><td align="center" valign="top" charoff="50">0.4</td><td align="center" valign="top" charoff="50">97%</td><td align="center" valign="top" charoff="50"><0.01</td></tr><tr><td align="left" valign="top" charoff="50"> </td><td align="center" valign="top" charoff="50">Removable</td><td align="center" valign="top" charoff="50">6</td><td align="center" valign="top" charoff="50">0.08 [−0.07, 0.23]</td><td align="center" valign="top" charoff="50">0.28</td><td align="center" valign="top" charoff="50">89%</td><td align="center" valign="top" charoff="50"><0.01</td></tr></tbody></table><table-wrap-foot><fn id="t3-fn1"><p>MBL = marginal bone loss.</p></fn></table-wrap-foot></table-wrap></floats-group></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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