Prevalence of Periodontitis in Patients with Established Rheumatoid Arthritis: A Swedish Population Based Case-Control Study
Identifieur interne : 000758 ( Pmc/Curation ); précédent : 000757; suivant : 000759Prevalence of Periodontitis in Patients with Established Rheumatoid Arthritis: A Swedish Population Based Case-Control Study
Auteurs : Kaja Eriksson [Suède] ; Lena Nise [Suède] ; Anna Kats [Suède] ; Elin Luttropp [Suède] ; Anca Irinel Catrina [Suède] ; Johan Askling [Suède] ; Leif Jansson [Suède] ; Lars Alfredsson [Suède] ; Lars Klareskog [Suède] ; Karin Lundberg [Suède] ; Tülay Yucel-Lindberg [Suède]Source :
- PLoS ONE [ 1932-6203 ] ; 2016.
Abstract
The possible hypothesis of a link between periodontitis and rheumatoid arthritis (RA), specifically anti-citrullinated protein antibody (ACPA) positive RA, prompted us to investigate the prevalence of periodontitis in the Swedish Epidemiological Investigation of RA (EIRA), a well-characterised population-based RA case-control cohort.
Periodontal status of 2,740 RA cases and 3,942 matched controls was retrieved through linking EIRA with the National Dental Health Registry (DHR), where dental diagnostic- and treatment codes on the adult Swedish population have been registered. Dental records from 100 cases and controls were reviewed to validate the periodontal diagnostic codes in DHR.
The reviewed dental records confirmed 90% of the periodontitis diagnoses in DHR among RA cases, and 88% among controls. We found the positive predictive value of periodontitis diagnoses in the DHR to be 89% (95% CI 78 to 95%) with a sensitivity of 77% (95% CI: 65 to 86%). In total, 86% of EIRA participants were identified in DHR. The risk for periodontitis increased by age and current smoking status in both cases as well as controls. No significant differences in prevalence of periodontal disease in terms of gingivitis, periodontitis, peri-implantitis or increased risk for periodontitis or peri-implantitis were observed between RA cases and controls. In addition, there was no difference on the basis of seropositivity, ACPA or rheumatoid factor (RF), among patients with RA.
Our data verify that smoking and ageing are risk factors for periodontitis, both in RA and controls. We found no evidence of an increased prevalence of periodontitis in patients with established RA compared to healthy controls, and no differences based on ACPA or RF status among RA subjects.
Url:
DOI: 10.1371/journal.pone.0155956
PubMed: 27203435
PubMed Central: 4874595
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: Pour aller vers cette notice dans l'étape Curation :000758
Links to Exploration step
PMC:4874595Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Prevalence of Periodontitis in Patients with Established Rheumatoid Arthritis: A Swedish Population Based Case-Control Study</title>
<author><name sortKey="Eriksson, Kaja" sort="Eriksson, Kaja" uniqKey="Eriksson K" first="Kaja" last="Eriksson">Kaja Eriksson</name>
<affiliation wicri:level="1"><nlm:aff id="aff001"><addr-line>Department of Dental Medicine, Division of Periodontology, Karolinska Institutet, Huddinge, Sweden</addr-line>
</nlm:aff>
<country xml:lang="fr">Suède</country>
<wicri:regionArea>Department of Dental Medicine, Division of Periodontology, Karolinska Institutet, Huddinge</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Nise, Lena" sort="Nise, Lena" uniqKey="Nise L" first="Lena" last="Nise">Lena Nise</name>
<affiliation wicri:level="1"><nlm:aff id="aff002"><addr-line>Institute of Environmental Medicine, Karolinska Institutet, Solna, Sweden</addr-line>
</nlm:aff>
<country xml:lang="fr">Suède</country>
<wicri:regionArea>Institute of Environmental Medicine, Karolinska Institutet, Solna</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Kats, Anna" sort="Kats, Anna" uniqKey="Kats A" first="Anna" last="Kats">Anna Kats</name>
<affiliation wicri:level="1"><nlm:aff id="aff001"><addr-line>Department of Dental Medicine, Division of Periodontology, Karolinska Institutet, Huddinge, Sweden</addr-line>
</nlm:aff>
<country xml:lang="fr">Suède</country>
<wicri:regionArea>Department of Dental Medicine, Division of Periodontology, Karolinska Institutet, Huddinge</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Luttropp, Elin" sort="Luttropp, Elin" uniqKey="Luttropp E" first="Elin" last="Luttropp">Elin Luttropp</name>
<affiliation wicri:level="1"><nlm:aff id="aff001"><addr-line>Department of Dental Medicine, Division of Periodontology, Karolinska Institutet, Huddinge, Sweden</addr-line>
</nlm:aff>
<country xml:lang="fr">Suède</country>
<wicri:regionArea>Department of Dental Medicine, Division of Periodontology, Karolinska Institutet, Huddinge</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Catrina, Anca Irinel" sort="Catrina, Anca Irinel" uniqKey="Catrina A" first="Anca Irinel" last="Catrina">Anca Irinel Catrina</name>
<affiliation wicri:level="1"><nlm:aff id="aff003"><addr-line>Department of Medicine, Rheumatology Unit, Karolinska University Hospital, Solna, Stockholm, Sweden</addr-line>
</nlm:aff>
<country xml:lang="fr">Suède</country>
<wicri:regionArea>Department of Medicine, Rheumatology Unit, Karolinska University Hospital, Solna, Stockholm</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Askling, Johan" sort="Askling, Johan" uniqKey="Askling J" first="Johan" last="Askling">Johan Askling</name>
<affiliation wicri:level="1"><nlm:aff id="aff003"><addr-line>Department of Medicine, Rheumatology Unit, Karolinska University Hospital, Solna, Stockholm, Sweden</addr-line>
</nlm:aff>
<country xml:lang="fr">Suède</country>
<wicri:regionArea>Department of Medicine, Rheumatology Unit, Karolinska University Hospital, Solna, Stockholm</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Jansson, Leif" sort="Jansson, Leif" uniqKey="Jansson L" first="Leif" last="Jansson">Leif Jansson</name>
<affiliation wicri:level="1"><nlm:aff id="aff001"><addr-line>Department of Dental Medicine, Division of Periodontology, Karolinska Institutet, Huddinge, Sweden</addr-line>
</nlm:aff>
<country xml:lang="fr">Suède</country>
<wicri:regionArea>Department of Dental Medicine, Division of Periodontology, Karolinska Institutet, Huddinge</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff004"><addr-line>Department of Periodontology at Eastmaninstitutet, Stockholm County Council, Stockholm, Sweden</addr-line>
</nlm:aff>
<country xml:lang="fr">Suède</country>
<wicri:regionArea>Department of Periodontology at Eastmaninstitutet, Stockholm County Council, Stockholm</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Alfredsson, Lars" sort="Alfredsson, Lars" uniqKey="Alfredsson L" first="Lars" last="Alfredsson">Lars Alfredsson</name>
<affiliation wicri:level="1"><nlm:aff id="aff002"><addr-line>Institute of Environmental Medicine, Karolinska Institutet, Solna, Sweden</addr-line>
</nlm:aff>
<country xml:lang="fr">Suède</country>
<wicri:regionArea>Institute of Environmental Medicine, Karolinska Institutet, Solna</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff005"><addr-line>Centre of Environmental and Occupational Medicine, Stockholm County Council, Stockholm, Sweden</addr-line>
</nlm:aff>
<country xml:lang="fr">Suède</country>
<wicri:regionArea>Centre of Environmental and Occupational Medicine, Stockholm County Council, Stockholm</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Klareskog, Lars" sort="Klareskog, Lars" uniqKey="Klareskog L" first="Lars" last="Klareskog">Lars Klareskog</name>
<affiliation wicri:level="1"><nlm:aff id="aff003"><addr-line>Department of Medicine, Rheumatology Unit, Karolinska University Hospital, Solna, Stockholm, Sweden</addr-line>
</nlm:aff>
<country xml:lang="fr">Suède</country>
<wicri:regionArea>Department of Medicine, Rheumatology Unit, Karolinska University Hospital, Solna, Stockholm</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Lundberg, Karin" sort="Lundberg, Karin" uniqKey="Lundberg K" first="Karin" last="Lundberg">Karin Lundberg</name>
<affiliation wicri:level="1"><nlm:aff id="aff003"><addr-line>Department of Medicine, Rheumatology Unit, Karolinska University Hospital, Solna, Stockholm, Sweden</addr-line>
</nlm:aff>
<country xml:lang="fr">Suède</country>
<wicri:regionArea>Department of Medicine, Rheumatology Unit, Karolinska University Hospital, Solna, Stockholm</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Yucel Lindberg, Tulay" sort="Yucel Lindberg, Tulay" uniqKey="Yucel Lindberg T" first="Tülay" last="Yucel-Lindberg">Tülay Yucel-Lindberg</name>
<affiliation wicri:level="1"><nlm:aff id="aff001"><addr-line>Department of Dental Medicine, Division of Periodontology, Karolinska Institutet, Huddinge, Sweden</addr-line>
</nlm:aff>
<country xml:lang="fr">Suède</country>
<wicri:regionArea>Department of Dental Medicine, Division of Periodontology, Karolinska Institutet, Huddinge</wicri:regionArea>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">27203435</idno>
<idno type="pmc">4874595</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4874595</idno>
<idno type="RBID">PMC:4874595</idno>
<idno type="doi">10.1371/journal.pone.0155956</idno>
<date when="2016">2016</date>
<idno type="wicri:Area/Pmc/Corpus">000758</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000758</idno>
<idno type="wicri:Area/Pmc/Curation">000758</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000758</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Prevalence of Periodontitis in Patients with Established Rheumatoid Arthritis: A Swedish Population Based Case-Control Study</title>
<author><name sortKey="Eriksson, Kaja" sort="Eriksson, Kaja" uniqKey="Eriksson K" first="Kaja" last="Eriksson">Kaja Eriksson</name>
<affiliation wicri:level="1"><nlm:aff id="aff001"><addr-line>Department of Dental Medicine, Division of Periodontology, Karolinska Institutet, Huddinge, Sweden</addr-line>
</nlm:aff>
<country xml:lang="fr">Suède</country>
<wicri:regionArea>Department of Dental Medicine, Division of Periodontology, Karolinska Institutet, Huddinge</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Nise, Lena" sort="Nise, Lena" uniqKey="Nise L" first="Lena" last="Nise">Lena Nise</name>
<affiliation wicri:level="1"><nlm:aff id="aff002"><addr-line>Institute of Environmental Medicine, Karolinska Institutet, Solna, Sweden</addr-line>
</nlm:aff>
<country xml:lang="fr">Suède</country>
<wicri:regionArea>Institute of Environmental Medicine, Karolinska Institutet, Solna</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Kats, Anna" sort="Kats, Anna" uniqKey="Kats A" first="Anna" last="Kats">Anna Kats</name>
<affiliation wicri:level="1"><nlm:aff id="aff001"><addr-line>Department of Dental Medicine, Division of Periodontology, Karolinska Institutet, Huddinge, Sweden</addr-line>
</nlm:aff>
<country xml:lang="fr">Suède</country>
<wicri:regionArea>Department of Dental Medicine, Division of Periodontology, Karolinska Institutet, Huddinge</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Luttropp, Elin" sort="Luttropp, Elin" uniqKey="Luttropp E" first="Elin" last="Luttropp">Elin Luttropp</name>
<affiliation wicri:level="1"><nlm:aff id="aff001"><addr-line>Department of Dental Medicine, Division of Periodontology, Karolinska Institutet, Huddinge, Sweden</addr-line>
</nlm:aff>
<country xml:lang="fr">Suède</country>
<wicri:regionArea>Department of Dental Medicine, Division of Periodontology, Karolinska Institutet, Huddinge</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Catrina, Anca Irinel" sort="Catrina, Anca Irinel" uniqKey="Catrina A" first="Anca Irinel" last="Catrina">Anca Irinel Catrina</name>
<affiliation wicri:level="1"><nlm:aff id="aff003"><addr-line>Department of Medicine, Rheumatology Unit, Karolinska University Hospital, Solna, Stockholm, Sweden</addr-line>
</nlm:aff>
<country xml:lang="fr">Suède</country>
<wicri:regionArea>Department of Medicine, Rheumatology Unit, Karolinska University Hospital, Solna, Stockholm</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Askling, Johan" sort="Askling, Johan" uniqKey="Askling J" first="Johan" last="Askling">Johan Askling</name>
<affiliation wicri:level="1"><nlm:aff id="aff003"><addr-line>Department of Medicine, Rheumatology Unit, Karolinska University Hospital, Solna, Stockholm, Sweden</addr-line>
</nlm:aff>
<country xml:lang="fr">Suède</country>
<wicri:regionArea>Department of Medicine, Rheumatology Unit, Karolinska University Hospital, Solna, Stockholm</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Jansson, Leif" sort="Jansson, Leif" uniqKey="Jansson L" first="Leif" last="Jansson">Leif Jansson</name>
<affiliation wicri:level="1"><nlm:aff id="aff001"><addr-line>Department of Dental Medicine, Division of Periodontology, Karolinska Institutet, Huddinge, Sweden</addr-line>
</nlm:aff>
<country xml:lang="fr">Suède</country>
<wicri:regionArea>Department of Dental Medicine, Division of Periodontology, Karolinska Institutet, Huddinge</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff004"><addr-line>Department of Periodontology at Eastmaninstitutet, Stockholm County Council, Stockholm, Sweden</addr-line>
</nlm:aff>
<country xml:lang="fr">Suède</country>
<wicri:regionArea>Department of Periodontology at Eastmaninstitutet, Stockholm County Council, Stockholm</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Alfredsson, Lars" sort="Alfredsson, Lars" uniqKey="Alfredsson L" first="Lars" last="Alfredsson">Lars Alfredsson</name>
<affiliation wicri:level="1"><nlm:aff id="aff002"><addr-line>Institute of Environmental Medicine, Karolinska Institutet, Solna, Sweden</addr-line>
</nlm:aff>
<country xml:lang="fr">Suède</country>
<wicri:regionArea>Institute of Environmental Medicine, Karolinska Institutet, Solna</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff005"><addr-line>Centre of Environmental and Occupational Medicine, Stockholm County Council, Stockholm, Sweden</addr-line>
</nlm:aff>
<country xml:lang="fr">Suède</country>
<wicri:regionArea>Centre of Environmental and Occupational Medicine, Stockholm County Council, Stockholm</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Klareskog, Lars" sort="Klareskog, Lars" uniqKey="Klareskog L" first="Lars" last="Klareskog">Lars Klareskog</name>
<affiliation wicri:level="1"><nlm:aff id="aff003"><addr-line>Department of Medicine, Rheumatology Unit, Karolinska University Hospital, Solna, Stockholm, Sweden</addr-line>
</nlm:aff>
<country xml:lang="fr">Suède</country>
<wicri:regionArea>Department of Medicine, Rheumatology Unit, Karolinska University Hospital, Solna, Stockholm</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Lundberg, Karin" sort="Lundberg, Karin" uniqKey="Lundberg K" first="Karin" last="Lundberg">Karin Lundberg</name>
<affiliation wicri:level="1"><nlm:aff id="aff003"><addr-line>Department of Medicine, Rheumatology Unit, Karolinska University Hospital, Solna, Stockholm, Sweden</addr-line>
</nlm:aff>
<country xml:lang="fr">Suède</country>
<wicri:regionArea>Department of Medicine, Rheumatology Unit, Karolinska University Hospital, Solna, Stockholm</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Yucel Lindberg, Tulay" sort="Yucel Lindberg, Tulay" uniqKey="Yucel Lindberg T" first="Tülay" last="Yucel-Lindberg">Tülay Yucel-Lindberg</name>
<affiliation wicri:level="1"><nlm:aff id="aff001"><addr-line>Department of Dental Medicine, Division of Periodontology, Karolinska Institutet, Huddinge, Sweden</addr-line>
</nlm:aff>
<country xml:lang="fr">Suède</country>
<wicri:regionArea>Department of Dental Medicine, Division of Periodontology, Karolinska Institutet, Huddinge</wicri:regionArea>
</affiliation>
</author>
</analytic>
<series><title level="j">PLoS ONE</title>
<idno type="eISSN">1932-6203</idno>
<imprint><date when="2016">2016</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><sec id="sec001"><title>Introduction</title>
<p>The possible hypothesis of a link between periodontitis and rheumatoid arthritis (RA), specifically anti-citrullinated protein antibody (ACPA) positive RA, prompted us to investigate the prevalence of periodontitis in the Swedish Epidemiological Investigation of RA (EIRA), a well-characterised population-based RA case-control cohort.</p>
</sec>
<sec id="sec002"><title>Methods</title>
<p>Periodontal status of 2,740 RA cases and 3,942 matched controls was retrieved through linking EIRA with the National Dental Health Registry (DHR), where dental diagnostic- and treatment codes on the adult Swedish population have been registered. Dental records from 100 cases and controls were reviewed to validate the periodontal diagnostic codes in DHR.</p>
</sec>
<sec id="sec003"><title>Results</title>
<p>The reviewed dental records confirmed 90% of the periodontitis diagnoses in DHR among RA cases, and 88% among controls. We found the positive predictive value of periodontitis diagnoses in the DHR to be 89% (95% CI 78 to 95%) with a sensitivity of 77% (95% CI: 65 to 86%). In total, 86% of EIRA participants were identified in DHR. The risk for periodontitis increased by age and current smoking status in both cases as well as controls. No significant differences in prevalence of periodontal disease in terms of gingivitis, periodontitis, peri-implantitis or increased risk for periodontitis or peri-implantitis were observed between RA cases and controls. In addition, there was no difference on the basis of seropositivity, ACPA or rheumatoid factor (RF), among patients with RA.</p>
</sec>
<sec id="sec004"><title>Conclusions</title>
<p>Our data verify that smoking and ageing are risk factors for periodontitis, both in RA and controls. We found no evidence of an increased prevalence of periodontitis in patients with established RA compared to healthy controls, and no differences based on ACPA or RF status among RA subjects.</p>
</sec>
</div>
</front>
<back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Klareskog, L" uniqKey="Klareskog L">L Klareskog</name>
</author>
<author><name sortKey="Catrina, Ai" uniqKey="Catrina A">AI Catrina</name>
</author>
<author><name sortKey="Paget, S" uniqKey="Paget S">S Paget</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Mcinnes, Ib" uniqKey="Mcinnes I">IB McInnes</name>
</author>
<author><name sortKey="Schett, G" uniqKey="Schett G">G Schett</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Bascones, A" uniqKey="Bascones A">A Bascones</name>
</author>
<author><name sortKey="Noronha, S" uniqKey="Noronha S">S Noronha</name>
</author>
<author><name sortKey="Gomez, M" uniqKey="Gomez M">M Gomez</name>
</author>
<author><name sortKey="Mota, P" uniqKey="Mota P">P Mota</name>
</author>
<author><name sortKey="Gonzalez Moles, Ma" uniqKey="Gonzalez Moles M">MA Gonzalez Moles</name>
</author>
<author><name sortKey="Villarroel Dorrego, M" uniqKey="Villarroel Dorrego M">M Villarroel Dorrego</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Janssen, Km" uniqKey="Janssen K">KM Janssen</name>
</author>
<author><name sortKey="Vissink, A" uniqKey="Vissink A">A Vissink</name>
</author>
<author><name sortKey="De Smit, Mj" uniqKey="De Smit M">MJ de Smit</name>
</author>
<author><name sortKey="Westra, J" uniqKey="Westra J">J Westra</name>
</author>
<author><name sortKey="Brouwer, E" uniqKey="Brouwer E">E Brouwer</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Bartold, Pm" uniqKey="Bartold P">PM Bartold</name>
</author>
<author><name sortKey="Marshall, Ri" uniqKey="Marshall R">RI Marshall</name>
</author>
<author><name sortKey="Haynes, Dr" uniqKey="Haynes D">DR Haynes</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Rosenstein, Ed" uniqKey="Rosenstein E">ED Rosenstein</name>
</author>
<author><name sortKey="Greenwald, Ra" uniqKey="Greenwald R">RA Greenwald</name>
</author>
<author><name sortKey="Kushner, Lj" uniqKey="Kushner L">LJ Kushner</name>
</author>
<author><name sortKey="Weissmann, G" uniqKey="Weissmann G">G Weissmann</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Stabholz, A" uniqKey="Stabholz A">A Stabholz</name>
</author>
<author><name sortKey="Soskolne, Wa" uniqKey="Soskolne W">WA Soskolne</name>
</author>
<author><name sortKey="Shapira, L" uniqKey="Shapira L">L Shapira</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Persson, Gr" uniqKey="Persson G">GR Persson</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Choy, E" uniqKey="Choy E">E Choy</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Yucel Lindberg, T" uniqKey="Yucel Lindberg T">T Yucel-Lindberg</name>
</author>
<author><name sortKey="Bage, T" uniqKey="Bage T">T Bage</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hajishengallis, G" uniqKey="Hajishengallis G">G Hajishengallis</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kasser, Ur" uniqKey="Kasser U">UR Kasser</name>
</author>
<author><name sortKey="Gleissner, C" uniqKey="Gleissner C">C Gleissner</name>
</author>
<author><name sortKey="Dehne, F" uniqKey="Dehne F">F Dehne</name>
</author>
<author><name sortKey="Michel, A" uniqKey="Michel A">A Michel</name>
</author>
<author><name sortKey="Willershausen Zonnchen, B" uniqKey="Willershausen Zonnchen B">B Willershausen-Zonnchen</name>
</author>
<author><name sortKey="Bolten, Ww" uniqKey="Bolten W">WW Bolten</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Mercado, Fb" uniqKey="Mercado F">FB Mercado</name>
</author>
<author><name sortKey="Marshall, Ri" uniqKey="Marshall R">RI Marshall</name>
</author>
<author><name sortKey="Klestov, Ac" uniqKey="Klestov A">AC Klestov</name>
</author>
<author><name sortKey="Bartold, Pm" uniqKey="Bartold P">PM Bartold</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Pischon, N" uniqKey="Pischon N">N Pischon</name>
</author>
<author><name sortKey="Pischon, T" uniqKey="Pischon T">T Pischon</name>
</author>
<author><name sortKey="Kroger, J" uniqKey="Kroger J">J Kroger</name>
</author>
<author><name sortKey="Gulmez, E" uniqKey="Gulmez E">E Gulmez</name>
</author>
<author><name sortKey="Kleber, Bm" uniqKey="Kleber B">BM Kleber</name>
</author>
<author><name sortKey="Bernimoulin, Jp" uniqKey="Bernimoulin J">JP Bernimoulin</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Garib, Bt" uniqKey="Garib B">BT Garib</name>
</author>
<author><name sortKey="Qaradaxi, Ss" uniqKey="Qaradaxi S">SS Qaradaxi</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Smit, Md" uniqKey="Smit M">MD Smit</name>
</author>
<author><name sortKey="Westra, J" uniqKey="Westra J">J Westra</name>
</author>
<author><name sortKey="Vissink, A" uniqKey="Vissink A">A Vissink</name>
</author>
<author><name sortKey="Doornbos Van Der Meer, B" uniqKey="Doornbos Van Der Meer B">B Doornbos-van der Meer</name>
</author>
<author><name sortKey="Brouwer, E" uniqKey="Brouwer E">E Brouwer</name>
</author>
<author><name sortKey="Van Winkelhoff, Aj" uniqKey="Van Winkelhoff A">AJ van Winkelhoff</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Scher, Ju" uniqKey="Scher J">JU Scher</name>
</author>
<author><name sortKey="Ubeda, C" uniqKey="Ubeda C">C Ubeda</name>
</author>
<author><name sortKey="Equinda, M" uniqKey="Equinda M">M Equinda</name>
</author>
<author><name sortKey="Khanin, R" uniqKey="Khanin R">R Khanin</name>
</author>
<author><name sortKey="Buischi, Y" uniqKey="Buischi Y">Y Buischi</name>
</author>
<author><name sortKey="Viale, A" uniqKey="Viale A">A Viale</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Potikuri, D" uniqKey="Potikuri D">D Potikuri</name>
</author>
<author><name sortKey="Dannana, Kc" uniqKey="Dannana K">KC Dannana</name>
</author>
<author><name sortKey="Kanchinadam, S" uniqKey="Kanchinadam S">S Kanchinadam</name>
</author>
<author><name sortKey="Agrawal, S" uniqKey="Agrawal S">S Agrawal</name>
</author>
<author><name sortKey="Kancharla, A" uniqKey="Kancharla A">A Kancharla</name>
</author>
<author><name sortKey="Rajasekhar, L" uniqKey="Rajasekhar L">L Rajasekhar</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Joseph, R" uniqKey="Joseph R">R Joseph</name>
</author>
<author><name sortKey="Rajappan, S" uniqKey="Rajappan S">S Rajappan</name>
</author>
<author><name sortKey="Nath, Sg" uniqKey="Nath S">SG Nath</name>
</author>
<author><name sortKey="Paul, Bj" uniqKey="Paul B">BJ Paul</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Bozkurt, Fy" uniqKey="Bozkurt F">FY Bozkurt</name>
</author>
<author><name sortKey="Berker, E" uniqKey="Berker E">E Berker</name>
</author>
<author><name sortKey="Akkus, S" uniqKey="Akkus S">S Akkus</name>
</author>
<author><name sortKey="Bulut, S" uniqKey="Bulut S">S Bulut</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Arkema, Ev" uniqKey="Arkema E">EV Arkema</name>
</author>
<author><name sortKey="Karlson, Ew" uniqKey="Karlson E">EW Karlson</name>
</author>
<author><name sortKey="Costenbader, Kh" uniqKey="Costenbader K">KH Costenbader</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Susanto, H" uniqKey="Susanto H">H Susanto</name>
</author>
<author><name sortKey="Nesse, W" uniqKey="Nesse W">W Nesse</name>
</author>
<author><name sortKey="Kertia, N" uniqKey="Kertia N">N Kertia</name>
</author>
<author><name sortKey="Soeroso, J" uniqKey="Soeroso J">J Soeroso</name>
</author>
<author><name sortKey="Huijser Van Reenen, Y" uniqKey="Huijser Van Reenen Y">Y Huijser van Reenen</name>
</author>
<author><name sortKey="Hoedemaker, E" uniqKey="Hoedemaker E">E Hoedemaker</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Okada, M" uniqKey="Okada M">M Okada</name>
</author>
<author><name sortKey="Kobayashi, T" uniqKey="Kobayashi T">T Kobayashi</name>
</author>
<author><name sortKey="Ito, S" uniqKey="Ito S">S Ito</name>
</author>
<author><name sortKey="Yokoyama, T" uniqKey="Yokoyama T">T Yokoyama</name>
</author>
<author><name sortKey="Komatsu, Y" uniqKey="Komatsu Y">Y Komatsu</name>
</author>
<author><name sortKey="Abe, A" uniqKey="Abe A">A Abe</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Sjostrom, L" uniqKey="Sjostrom L">L Sjostrom</name>
</author>
<author><name sortKey="Laurell, L" uniqKey="Laurell L">L Laurell</name>
</author>
<author><name sortKey="Hugoson, A" uniqKey="Hugoson A">A Hugoson</name>
</author>
<author><name sortKey="Hakansson, Jp" uniqKey="Hakansson J">JP Hakansson</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kobayashi, T" uniqKey="Kobayashi T">T Kobayashi</name>
</author>
<author><name sortKey="Ito, S" uniqKey="Ito S">S Ito</name>
</author>
<author><name sortKey="Kuroda, T" uniqKey="Kuroda T">T Kuroda</name>
</author>
<author><name sortKey="Yamamoto, K" uniqKey="Yamamoto K">K Yamamoto</name>
</author>
<author><name sortKey="Sugita, N" uniqKey="Sugita N">N Sugita</name>
</author>
<author><name sortKey="Narita, I" uniqKey="Narita I">I Narita</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Mirrielees, J" uniqKey="Mirrielees J">J Mirrielees</name>
</author>
<author><name sortKey="Crofford, Lj" uniqKey="Crofford L">LJ Crofford</name>
</author>
<author><name sortKey="Lin, Y" uniqKey="Lin Y">Y Lin</name>
</author>
<author><name sortKey="Kryscio, Rj" uniqKey="Kryscio R">RJ Kryscio</name>
</author>
<author><name sortKey="Dawson, Dr" uniqKey="Dawson D">DR Dawson</name>
</author>
<author><name sortKey="Ebersole, Jl" uniqKey="Ebersole J">JL Ebersole</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Chen, Hh" uniqKey="Chen H">HH Chen</name>
</author>
<author><name sortKey="Huang, N" uniqKey="Huang N">N Huang</name>
</author>
<author><name sortKey="Chen, Ym" uniqKey="Chen Y">YM Chen</name>
</author>
<author><name sortKey="Chen, Tj" uniqKey="Chen T">TJ Chen</name>
</author>
<author><name sortKey="Chou, P" uniqKey="Chou P">P Chou</name>
</author>
<author><name sortKey="Lee, Yl" uniqKey="Lee Y">YL Lee</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="De Pablo, P" uniqKey="De Pablo P">P de Pablo</name>
</author>
<author><name sortKey="Dietrich, T" uniqKey="Dietrich T">T Dietrich</name>
</author>
<author><name sortKey="Mcalindon, Te" uniqKey="Mcalindon T">TE McAlindon</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Demmer, Rt" uniqKey="Demmer R">RT Demmer</name>
</author>
<author><name sortKey="Molitor, Ja" uniqKey="Molitor J">JA Molitor</name>
</author>
<author><name sortKey="Jacobs, Dr" uniqKey="Jacobs D">DR Jacobs</name>
</author>
<author><name sortKey="Michalowicz, Bs" uniqKey="Michalowicz B">BS Michalowicz</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Van Der Helm Van Mil, Ah" uniqKey="Van Der Helm Van Mil A">AH van der Helm-van Mil</name>
</author>
<author><name sortKey="Verpoort, Kn" uniqKey="Verpoort K">KN Verpoort</name>
</author>
<author><name sortKey="Breedveld, Fc" uniqKey="Breedveld F">FC Breedveld</name>
</author>
<author><name sortKey="Toes, Re" uniqKey="Toes R">RE Toes</name>
</author>
<author><name sortKey="Huizinga, Tw" uniqKey="Huizinga T">TW Huizinga</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Klareskog, L" uniqKey="Klareskog L">L Klareskog</name>
</author>
<author><name sortKey="Ronnelid, J" uniqKey="Ronnelid J">J Ronnelid</name>
</author>
<author><name sortKey="Lundberg, K" uniqKey="Lundberg K">K Lundberg</name>
</author>
<author><name sortKey="Padyukov, L" uniqKey="Padyukov L">L Padyukov</name>
</author>
<author><name sortKey="Alfredsson, L" uniqKey="Alfredsson L">L Alfredsson</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Mahdi, H" uniqKey="Mahdi H">H Mahdi</name>
</author>
<author><name sortKey="Fisher, Ba" uniqKey="Fisher B">BA Fisher</name>
</author>
<author><name sortKey="Kallberg, H" uniqKey="Kallberg H">H Kallberg</name>
</author>
<author><name sortKey="Plant, D" uniqKey="Plant D">D Plant</name>
</author>
<author><name sortKey="Malmstrom, V" uniqKey="Malmstrom V">V Malmstrom</name>
</author>
<author><name sortKey="Ronnelid, J" uniqKey="Ronnelid J">J Ronnelid</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Klareskog, L" uniqKey="Klareskog L">L Klareskog</name>
</author>
<author><name sortKey="Stolt, P" uniqKey="Stolt P">P Stolt</name>
</author>
<author><name sortKey="Lundberg, K" uniqKey="Lundberg K">K Lundberg</name>
</author>
<author><name sortKey="Kallberg, H" uniqKey="Kallberg H">H Kallberg</name>
</author>
<author><name sortKey="Bengtsson, C" uniqKey="Bengtsson C">C Bengtsson</name>
</author>
<author><name sortKey="Grunewald, J" uniqKey="Grunewald J">J Grunewald</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Harvey, Gp" uniqKey="Harvey G">GP Harvey</name>
</author>
<author><name sortKey="Fitzsimmons, Tr" uniqKey="Fitzsimmons T">TR Fitzsimmons</name>
</author>
<author><name sortKey="Dhamarpatni, Aa" uniqKey="Dhamarpatni A">AA Dhamarpatni</name>
</author>
<author><name sortKey="Marchant, C" uniqKey="Marchant C">C Marchant</name>
</author>
<author><name sortKey="Haynes, Dr" uniqKey="Haynes D">DR Haynes</name>
</author>
<author><name sortKey="Bartold, Pm" uniqKey="Bartold P">PM Bartold</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lappin, Df" uniqKey="Lappin D">DF Lappin</name>
</author>
<author><name sortKey="Apatzidou, D" uniqKey="Apatzidou D">D Apatzidou</name>
</author>
<author><name sortKey="Quirke, Am" uniqKey="Quirke A">AM Quirke</name>
</author>
<author><name sortKey="Oliver Bell, J" uniqKey="Oliver Bell J">J Oliver-Bell</name>
</author>
<author><name sortKey="Butcher, Jp" uniqKey="Butcher J">JP Butcher</name>
</author>
<author><name sortKey="Kinane, Df" uniqKey="Kinane D">DF Kinane</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hendler, A" uniqKey="Hendler A">A Hendler</name>
</author>
<author><name sortKey="Mulli, Tk" uniqKey="Mulli T">TK Mulli</name>
</author>
<author><name sortKey="Hughes, Fj" uniqKey="Hughes F">FJ Hughes</name>
</author>
<author><name sortKey="Perrett, D" uniqKey="Perrett D">D Perrett</name>
</author>
<author><name sortKey="Bombardieri, M" uniqKey="Bombardieri M">M Bombardieri</name>
</author>
<author><name sortKey="Houri Haddad, Y" uniqKey="Houri Haddad Y">Y Houri-Haddad</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Wegner, N" uniqKey="Wegner N">N Wegner</name>
</author>
<author><name sortKey="Wait, R" uniqKey="Wait R">R Wait</name>
</author>
<author><name sortKey="Sroka, A" uniqKey="Sroka A">A Sroka</name>
</author>
<author><name sortKey="Eick, S" uniqKey="Eick S">S Eick</name>
</author>
<author><name sortKey="Nguyen, Ka" uniqKey="Nguyen K">KA Nguyen</name>
</author>
<author><name sortKey="Lundberg, K" uniqKey="Lundberg K">K Lundberg</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kaur, S" uniqKey="Kaur S">S Kaur</name>
</author>
<author><name sortKey="White, S" uniqKey="White S">S White</name>
</author>
<author><name sortKey="Bartold, Pm" uniqKey="Bartold P">PM Bartold</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Linden, Gj" uniqKey="Linden G">GJ Linden</name>
</author>
<author><name sortKey="Lyons, A" uniqKey="Lyons A">A Lyons</name>
</author>
<author><name sortKey="Scannapieco, Fa" uniqKey="Scannapieco F">FA Scannapieco</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Payne, Jb" uniqKey="Payne J">JB Payne</name>
</author>
<author><name sortKey="Golub, Lm" uniqKey="Golub L">LM Golub</name>
</author>
<author><name sortKey="Thiele, Gm" uniqKey="Thiele G">GM Thiele</name>
</author>
<author><name sortKey="Mikuls, Tr" uniqKey="Mikuls T">TR Mikuls</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Bengtsson, C" uniqKey="Bengtsson C">C Bengtsson</name>
</author>
<author><name sortKey="Nordmark, B" uniqKey="Nordmark B">B Nordmark</name>
</author>
<author><name sortKey="Klareskog, L" uniqKey="Klareskog L">L Klareskog</name>
</author>
<author><name sortKey="Lundberg, I" uniqKey="Lundberg I">I Lundberg</name>
</author>
<author><name sortKey="Alfredsson, L" uniqKey="Alfredsson L">L Alfredsson</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kallberg, H" uniqKey="Kallberg H">H Kallberg</name>
</author>
<author><name sortKey="Vieira, V" uniqKey="Vieira V">V Vieira</name>
</author>
<author><name sortKey="Holmqvist, M" uniqKey="Holmqvist M">M Holmqvist</name>
</author>
<author><name sortKey="Hart, Je" uniqKey="Hart J">JE Hart</name>
</author>
<author><name sortKey="Costenbader, Kh" uniqKey="Costenbader K">KH Costenbader</name>
</author>
<author><name sortKey="Bengtsson, C" uniqKey="Bengtsson C">C Bengtsson</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Arnett, Fc" uniqKey="Arnett F">FC Arnett</name>
</author>
<author><name sortKey="Edworthy, Sm" uniqKey="Edworthy S">SM Edworthy</name>
</author>
<author><name sortKey="Bloch, Da" uniqKey="Bloch D">DA Bloch</name>
</author>
<author><name sortKey="Mcshane, Dj" uniqKey="Mcshane D">DJ McShane</name>
</author>
<author><name sortKey="Fries, Jf" uniqKey="Fries J">JF Fries</name>
</author>
<author><name sortKey="Cooper, Ns" uniqKey="Cooper N">NS Cooper</name>
</author>
</analytic>
</biblStruct>
<biblStruct></biblStruct>
<biblStruct><analytic><author><name sortKey="Stolt, P" uniqKey="Stolt P">P Stolt</name>
</author>
<author><name sortKey="Bengtsson, C" uniqKey="Bengtsson C">C Bengtsson</name>
</author>
<author><name sortKey="Nordmark, B" uniqKey="Nordmark B">B Nordmark</name>
</author>
<author><name sortKey="Lindblad, S" uniqKey="Lindblad S">S Lindblad</name>
</author>
<author><name sortKey="Lundberg, I" uniqKey="Lundberg I">I Lundberg</name>
</author>
<author><name sortKey="Klareskog, L" uniqKey="Klareskog L">L Klareskog</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Tomar, Sl" uniqKey="Tomar S">SL Tomar</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Coburn, Bw" uniqKey="Coburn B">BW Coburn</name>
</author>
<author><name sortKey="Sayles, Hr" uniqKey="Sayles H">HR Sayles</name>
</author>
<author><name sortKey="Payne, Jb" uniqKey="Payne J">JB Payne</name>
</author>
<author><name sortKey="Redman, Rs" uniqKey="Redman R">RS Redman</name>
</author>
<author><name sortKey="Markt, Jc" uniqKey="Markt J">JC Markt</name>
</author>
<author><name sortKey="Beatty, Mw" uniqKey="Beatty M">MW Beatty</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Blicher, B" uniqKey="Blicher B">B Blicher</name>
</author>
<author><name sortKey="Joshipura, K" uniqKey="Joshipura K">K Joshipura</name>
</author>
<author><name sortKey="Eke, P" uniqKey="Eke P">P Eke</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Shiau, Hj" uniqKey="Shiau H">HJ Shiau</name>
</author>
<author><name sortKey="Reynolds, Ma" uniqKey="Reynolds M">MA Reynolds</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Pihlstrom, Bl" uniqKey="Pihlstrom B">BL Pihlstrom</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Burt, B" uniqKey="Burt B">B Burt</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Gerlag, Dm" uniqKey="Gerlag D">DM Gerlag</name>
</author>
<author><name sortKey="Norris, Jm" uniqKey="Norris J">JM Norris</name>
</author>
<author><name sortKey="Tak, Pp" uniqKey="Tak P">PP Tak</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Biyikoglu, B" uniqKey="Biyikoglu B">B Biyikoglu</name>
</author>
<author><name sortKey="Buduneli, N" uniqKey="Buduneli N">N Buduneli</name>
</author>
<author><name sortKey="Kardesler, L" uniqKey="Kardesler L">L Kardesler</name>
</author>
<author><name sortKey="Aksu, K" uniqKey="Aksu K">K Aksu</name>
</author>
<author><name sortKey="Oder, G" uniqKey="Oder G">G Oder</name>
</author>
<author><name sortKey="Kutukculer, N" uniqKey="Kutukculer N">N Kutukculer</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="De Smit, M" uniqKey="De Smit M">M de Smit</name>
</author>
<author><name sortKey="Westra, J" uniqKey="Westra J">J Westra</name>
</author>
<author><name sortKey="Vissink, A" uniqKey="Vissink A">A Vissink</name>
</author>
<author><name sortKey="Doornbos Van Der Meer, B" uniqKey="Doornbos Van Der Meer B">B Doornbos-van der Meer</name>
</author>
<author><name sortKey="Brouwer, E" uniqKey="Brouwer E">E Brouwer</name>
</author>
<author><name sortKey="Van Winkelhoff, Aj" uniqKey="Van Winkelhoff A">AJ van Winkelhoff</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Wolff, B" uniqKey="Wolff B">B Wolff</name>
</author>
<author><name sortKey="Berger, T" uniqKey="Berger T">T Berger</name>
</author>
<author><name sortKey="Frese, C" uniqKey="Frese C">C Frese</name>
</author>
<author><name sortKey="Max, R" uniqKey="Max R">R Max</name>
</author>
<author><name sortKey="Blank, N" uniqKey="Blank N">N Blank</name>
</author>
<author><name sortKey="Lorenz, Hm" uniqKey="Lorenz H">HM Lorenz</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Araujo, Vm" uniqKey="Araujo V">VM Araujo</name>
</author>
<author><name sortKey="Melo, Im" uniqKey="Melo I">IM Melo</name>
</author>
<author><name sortKey="Lima, V" uniqKey="Lima V">V Lima</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Fuggle, Nr" uniqKey="Fuggle N">NR Fuggle</name>
</author>
<author><name sortKey="Smith, To" uniqKey="Smith T">TO Smith</name>
</author>
<author><name sortKey="Kaul, A" uniqKey="Kaul A">A Kaul</name>
</author>
<author><name sortKey="Sofat, N" uniqKey="Sofat N">N Sofat</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Dissick, A" uniqKey="Dissick A">A Dissick</name>
</author>
<author><name sortKey="Redman, Rs" uniqKey="Redman R">RS Redman</name>
</author>
<author><name sortKey="Jones, M" uniqKey="Jones M">M Jones</name>
</author>
<author><name sortKey="Rangan, Bv" uniqKey="Rangan B">BV Rangan</name>
</author>
<author><name sortKey="Reimold, A" uniqKey="Reimold A">A Reimold</name>
</author>
<author><name sortKey="Griffiths, Gr" uniqKey="Griffiths G">GR Griffiths</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Mikuls, Tr" uniqKey="Mikuls T">TR Mikuls</name>
</author>
<author><name sortKey="Payne, Jb" uniqKey="Payne J">JB Payne</name>
</author>
<author><name sortKey="Yu, F" uniqKey="Yu F">F Yu</name>
</author>
<author><name sortKey="Thiele, Gm" uniqKey="Thiele G">GM Thiele</name>
</author>
<author><name sortKey="Reynolds, Rj" uniqKey="Reynolds R">RJ Reynolds</name>
</author>
<author><name sortKey="Cannon, Gw" uniqKey="Cannon G">GW Cannon</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Gonzalez, Sm" uniqKey="Gonzalez S">SM Gonzalez</name>
</author>
<author><name sortKey="Payne, Jb" uniqKey="Payne J">JB Payne</name>
</author>
<author><name sortKey="Yu, F" uniqKey="Yu F">F Yu</name>
</author>
<author><name sortKey="Thiele, Gm" uniqKey="Thiele G">GM Thiele</name>
</author>
<author><name sortKey="Erickson, Ar" uniqKey="Erickson A">AR Erickson</name>
</author>
<author><name sortKey="Johnson, Pg" uniqKey="Johnson P">PG Johnson</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Liao, Kp" uniqKey="Liao K">KP Liao</name>
</author>
<author><name sortKey="Gunnarsson, M" uniqKey="Gunnarsson M">M Gunnarsson</name>
</author>
<author><name sortKey="Kallberg, H" uniqKey="Kallberg H">H Kallberg</name>
</author>
<author><name sortKey="Ding, B" uniqKey="Ding B">B Ding</name>
</author>
<author><name sortKey="Plenge, Rm" uniqKey="Plenge R">RM Plenge</name>
</author>
<author><name sortKey="Padyukov, L" uniqKey="Padyukov L">L Padyukov</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Llambes, F" uniqKey="Llambes F">F Llambes</name>
</author>
<author><name sortKey="Arias Herrera, S" uniqKey="Arias Herrera S">S Arias-Herrera</name>
</author>
<author><name sortKey="Caffesse, R" uniqKey="Caffesse R">R Caffesse</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Howell, Th" uniqKey="Howell T">TH Howell</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Delima, Aj" uniqKey="Delima A">AJ Delima</name>
</author>
<author><name sortKey="Oates, T" uniqKey="Oates T">T Oates</name>
</author>
<author><name sortKey="Assuma, R" uniqKey="Assuma R">R Assuma</name>
</author>
<author><name sortKey="Schwartz, Z" uniqKey="Schwartz Z">Z Schwartz</name>
</author>
<author><name sortKey="Cochran, D" uniqKey="Cochran D">D Cochran</name>
</author>
<author><name sortKey="Amar, S" uniqKey="Amar S">S Amar</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ortiz, P" uniqKey="Ortiz P">P Ortiz</name>
</author>
<author><name sortKey="Bissada, Nf" uniqKey="Bissada N">NF Bissada</name>
</author>
<author><name sortKey="Palomo, L" uniqKey="Palomo L">L Palomo</name>
</author>
<author><name sortKey="Han, Yw" uniqKey="Han Y">YW Han</name>
</author>
<author><name sortKey="Al Zahrani, Ms" uniqKey="Al Zahrani M">MS Al-Zahrani</name>
</author>
<author><name sortKey="Panneerselvam, A" uniqKey="Panneerselvam A">A Panneerselvam</name>
</author>
</analytic>
</biblStruct>
</listBibl>
</div1>
</back>
</TEI>
<pmc article-type="research-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">PLoS One</journal-id>
<journal-id journal-id-type="iso-abbrev">PLoS ONE</journal-id>
<journal-id journal-id-type="publisher-id">plos</journal-id>
<journal-id journal-id-type="pmc">plosone</journal-id>
<journal-title-group><journal-title>PLoS ONE</journal-title>
</journal-title-group>
<issn pub-type="epub">1932-6203</issn>
<publisher><publisher-name>Public Library of Science</publisher-name>
<publisher-loc>San Francisco, CA USA</publisher-loc>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">27203435</article-id>
<article-id pub-id-type="pmc">4874595</article-id>
<article-id pub-id-type="doi">10.1371/journal.pone.0155956</article-id>
<article-id pub-id-type="publisher-id">PONE-D-16-01505</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject>
</subj-group>
<subj-group subj-group-type="Discipline-v3"><subject>Medicine and Health Sciences</subject>
<subj-group><subject>Rheumatology</subject>
<subj-group><subject>Arthritis</subject>
<subj-group><subject>Rheumatoid Arthritis</subject>
</subj-group>
</subj-group>
</subj-group>
</subj-group>
<subj-group subj-group-type="Discipline-v3"><subject>Medicine and Health Sciences</subject>
<subj-group><subject>Clinical Medicine</subject>
<subj-group><subject>Clinical Immunology</subject>
<subj-group><subject>Autoimmune Diseases</subject>
<subj-group><subject>Rheumatoid Arthritis</subject>
</subj-group>
</subj-group>
</subj-group>
</subj-group>
</subj-group>
<subj-group subj-group-type="Discipline-v3"><subject>Biology and Life Sciences</subject>
<subj-group><subject>Immunology</subject>
<subj-group><subject>Clinical Immunology</subject>
<subj-group><subject>Autoimmune Diseases</subject>
<subj-group><subject>Rheumatoid Arthritis</subject>
</subj-group>
</subj-group>
</subj-group>
</subj-group>
</subj-group>
<subj-group subj-group-type="Discipline-v3"><subject>Medicine and Health Sciences</subject>
<subj-group><subject>Immunology</subject>
<subj-group><subject>Clinical Immunology</subject>
<subj-group><subject>Autoimmune Diseases</subject>
<subj-group><subject>Rheumatoid Arthritis</subject>
</subj-group>
</subj-group>
</subj-group>
</subj-group>
</subj-group>
<subj-group subj-group-type="Discipline-v3"><subject>Medicine and Health Sciences</subject>
<subj-group><subject>Oral Medicine</subject>
<subj-group><subject>Oral Diseases</subject>
<subj-group><subject>Periodontal Diseases</subject>
<subj-group><subject>Periodontitis</subject>
</subj-group>
</subj-group>
</subj-group>
</subj-group>
</subj-group>
<subj-group subj-group-type="Discipline-v3"><subject>Medicine and Health Sciences</subject>
<subj-group><subject>Diagnostic Medicine</subject>
</subj-group>
</subj-group>
<subj-group subj-group-type="Discipline-v3"><subject>Medicine and Health Sciences</subject>
<subj-group><subject>Infectious Diseases</subject>
<subj-group><subject>Infectious Disease Control</subject>
</subj-group>
</subj-group>
</subj-group>
<subj-group subj-group-type="Discipline-v3"><subject>Medicine and Health Sciences</subject>
<subj-group><subject>Oral Medicine</subject>
<subj-group><subject>Oral Diseases</subject>
<subj-group><subject>Periodontal Diseases</subject>
</subj-group>
</subj-group>
</subj-group>
</subj-group>
<subj-group subj-group-type="Discipline-v3"><subject>Biology and Life Sciences</subject>
<subj-group><subject>Behavior</subject>
<subj-group><subject>Habits</subject>
<subj-group><subject>Smoking Habits</subject>
</subj-group>
</subj-group>
</subj-group>
</subj-group>
<subj-group subj-group-type="Discipline-v3"><subject>People and Places</subject>
<subj-group><subject>Population Groupings</subject>
<subj-group><subject>Ethnicities</subject>
<subj-group><subject>Swedes</subject>
</subj-group>
</subj-group>
</subj-group>
</subj-group>
<subj-group subj-group-type="Discipline-v3"><subject>Medicine and Health Sciences</subject>
<subj-group><subject>Pathology and Laboratory Medicine</subject>
<subj-group><subject>Pathogens</subject>
</subj-group>
</subj-group>
</subj-group>
</article-categories>
<title-group><article-title>Prevalence of Periodontitis in Patients with Established Rheumatoid Arthritis: A Swedish Population Based Case-Control Study</article-title>
<alt-title alt-title-type="running-head">Prevalence of Periodontitis and Rheumatoid Arthritis</alt-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Eriksson</surname>
<given-names>Kaja</given-names>
</name>
<xref ref-type="aff" rid="aff001"><sup>1</sup>
</xref>
<xref ref-type="corresp" rid="cor001">*</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Nise</surname>
<given-names>Lena</given-names>
</name>
<xref ref-type="aff" rid="aff002"><sup>2</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Kats</surname>
<given-names>Anna</given-names>
</name>
<xref ref-type="aff" rid="aff001"><sup>1</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Luttropp</surname>
<given-names>Elin</given-names>
</name>
<xref ref-type="aff" rid="aff001"><sup>1</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Catrina</surname>
<given-names>Anca Irinel</given-names>
</name>
<xref ref-type="aff" rid="aff003"><sup>3</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Askling</surname>
<given-names>Johan</given-names>
</name>
<xref ref-type="aff" rid="aff003"><sup>3</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Jansson</surname>
<given-names>Leif</given-names>
</name>
<xref ref-type="aff" rid="aff001"><sup>1</sup>
</xref>
<xref ref-type="aff" rid="aff004"><sup>4</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Alfredsson</surname>
<given-names>Lars</given-names>
</name>
<xref ref-type="aff" rid="aff002"><sup>2</sup>
</xref>
<xref ref-type="aff" rid="aff005"><sup>5</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Klareskog</surname>
<given-names>Lars</given-names>
</name>
<xref ref-type="aff" rid="aff003"><sup>3</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Lundberg</surname>
<given-names>Karin</given-names>
</name>
<xref ref-type="aff" rid="aff003"><sup>3</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Yucel-Lindberg</surname>
<given-names>Tülay</given-names>
</name>
<xref ref-type="aff" rid="aff001"><sup>1</sup>
</xref>
<xref ref-type="corresp" rid="cor001">*</xref>
</contrib>
</contrib-group>
<aff id="aff001"><label>1</label>
<addr-line>Department of Dental Medicine, Division of Periodontology, Karolinska Institutet, Huddinge, Sweden</addr-line>
</aff>
<aff id="aff002"><label>2</label>
<addr-line>Institute of Environmental Medicine, Karolinska Institutet, Solna, Sweden</addr-line>
</aff>
<aff id="aff003"><label>3</label>
<addr-line>Department of Medicine, Rheumatology Unit, Karolinska University Hospital, Solna, Stockholm, Sweden</addr-line>
</aff>
<aff id="aff004"><label>4</label>
<addr-line>Department of Periodontology at Eastmaninstitutet, Stockholm County Council, Stockholm, Sweden</addr-line>
</aff>
<aff id="aff005"><label>5</label>
<addr-line>Centre of Environmental and Occupational Medicine, Stockholm County Council, Stockholm, Sweden</addr-line>
</aff>
<contrib-group><contrib contrib-type="editor"><name><surname>Kuwana</surname>
<given-names>Masataka</given-names>
</name>
<role>Editor</role>
<xref ref-type="aff" rid="edit1"></xref>
</contrib>
</contrib-group>
<aff id="edit1"><addr-line>Nippon Medical School Graduate School of Medicine, JAPAN</addr-line>
</aff>
<author-notes><fn fn-type="conflict" id="coi001"><p><bold>Competing Interests: </bold>
The authors have declared that no competing interests exist.</p>
</fn>
<fn fn-type="con" id="contrib001"><p>Conceived and designed the experiments: TYL LK LA AIC AK KL JA KE EL. Performed the experiments: KE LN AK EL LA LK KL TYL. Analyzed the data: LN TYL KE KL LA LK JA AIC LJ AK EL. Contributed reagents/materials/analysis tools: LK LA TYL KL KE AK LN EL LJ. Wrote the paper: KE TYL KL LK AIC JA AK LA LN LJ EL.</p>
</fn>
<corresp id="cor001">* E-mail: <email>Tulay.Lindberg@ki.se</email>
(TYL); <email>Kaja.Eriksson@ki.se</email>
(KE)</corresp>
</author-notes>
<pub-date pub-type="epub"><day>20</day>
<month>5</month>
<year>2016</year>
</pub-date>
<pub-date pub-type="collection"><year>2016</year>
</pub-date>
<volume>11</volume>
<issue>5</issue>
<elocation-id>e0155956</elocation-id>
<history><date date-type="received"><day>12</day>
<month>1</month>
<year>2016</year>
</date>
<date date-type="accepted"><day>6</day>
<month>5</month>
<year>2016</year>
</date>
</history>
<permissions><copyright-statement>© 2016 Eriksson et al</copyright-statement>
<copyright-year>2016</copyright-year>
<copyright-holder>Eriksson et al</copyright-holder>
<license xlink:href="http://creativecommons.org/licenses/by/4.0/"><license-p>This is an open access article distributed under the terms of the <ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by/4.0/">Creative Commons Attribution License</ext-link>
, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.</license-p>
</license>
</permissions>
<self-uri content-type="pdf" xlink:href="pone.0155956.pdf"></self-uri>
<abstract><sec id="sec001"><title>Introduction</title>
<p>The possible hypothesis of a link between periodontitis and rheumatoid arthritis (RA), specifically anti-citrullinated protein antibody (ACPA) positive RA, prompted us to investigate the prevalence of periodontitis in the Swedish Epidemiological Investigation of RA (EIRA), a well-characterised population-based RA case-control cohort.</p>
</sec>
<sec id="sec002"><title>Methods</title>
<p>Periodontal status of 2,740 RA cases and 3,942 matched controls was retrieved through linking EIRA with the National Dental Health Registry (DHR), where dental diagnostic- and treatment codes on the adult Swedish population have been registered. Dental records from 100 cases and controls were reviewed to validate the periodontal diagnostic codes in DHR.</p>
</sec>
<sec id="sec003"><title>Results</title>
<p>The reviewed dental records confirmed 90% of the periodontitis diagnoses in DHR among RA cases, and 88% among controls. We found the positive predictive value of periodontitis diagnoses in the DHR to be 89% (95% CI 78 to 95%) with a sensitivity of 77% (95% CI: 65 to 86%). In total, 86% of EIRA participants were identified in DHR. The risk for periodontitis increased by age and current smoking status in both cases as well as controls. No significant differences in prevalence of periodontal disease in terms of gingivitis, periodontitis, peri-implantitis or increased risk for periodontitis or peri-implantitis were observed between RA cases and controls. In addition, there was no difference on the basis of seropositivity, ACPA or rheumatoid factor (RF), among patients with RA.</p>
</sec>
<sec id="sec004"><title>Conclusions</title>
<p>Our data verify that smoking and ageing are risk factors for periodontitis, both in RA and controls. We found no evidence of an increased prevalence of periodontitis in patients with established RA compared to healthy controls, and no differences based on ACPA or RF status among RA subjects.</p>
</sec>
</abstract>
<funding-group><award-group id="award001"><funding-source><institution-wrap><institution-id institution-id-type="funder-id">http://dx.doi.org/10.13039/501100004963</institution-id>
<institution>Seventh Framework Programme</institution>
</institution-wrap>
</funding-source>
<award-id>FP7HEALTH-2010-261460</award-id>
<principal-award-recipient><name><surname>Klareskog</surname>
<given-names>Lars</given-names>
</name>
</principal-award-recipient>
</award-group>
<award-group id="award002"><funding-source><institution-wrap><institution-id institution-id-type="funder-id">http://dx.doi.org/10.13039/501100004963</institution-id>
<institution>Seventh Framework Programme</institution>
</institution-wrap>
</funding-source>
<award-id>306029</award-id>
<principal-award-recipient><name><surname>Lundberg</surname>
<given-names>Karin</given-names>
</name>
</principal-award-recipient>
</award-group>
<award-group id="award003"><funding-source><institution-wrap><institution-id institution-id-type="funder-id">http://dx.doi.org/10.13039/501100004348</institution-id>
<institution>Stockholms Läns Landsting</institution>
</institution-wrap>
</funding-source>
<principal-award-recipient><name><surname>Yucel-Lindberg</surname>
<given-names>Tülay</given-names>
</name>
</principal-award-recipient>
</award-group>
<award-group id="award004"><funding-source><institution-wrap><institution-id institution-id-type="funder-id">http://dx.doi.org/10.13039/501100004359</institution-id>
<institution>Vetenskapsrådet</institution>
</institution-wrap>
</funding-source>
<principal-award-recipient><name><surname>Yucel-Lindberg</surname>
<given-names>Tülay</given-names>
</name>
</principal-award-recipient>
</award-group>
<award-group id="award005"><funding-source><institution-wrap><institution-id institution-id-type="funder-id">http://dx.doi.org/10.13039/501100004047</institution-id>
<institution>Karolinska Institutet</institution>
</institution-wrap>
</funding-source>
<principal-award-recipient><name><surname>Eriksson</surname>
<given-names>Kaja</given-names>
</name>
</principal-award-recipient>
</award-group>
<award-group id="award006"><funding-source><institution-wrap><institution-id institution-id-type="funder-id">http://dx.doi.org/10.13039/501100005301</institution-id>
<institution>Svenska Tandläkare-Sällskapet</institution>
</institution-wrap>
</funding-source>
<principal-award-recipient><name><surname>Eriksson</surname>
<given-names>Kaja</given-names>
</name>
</principal-award-recipient>
</award-group>
<award-group id="award007"><funding-source><institution>Swedish Rheumatic Foundation</institution>
</funding-source>
<principal-award-recipient><name><surname>Klareskog</surname>
<given-names>Lars</given-names>
</name>
</principal-award-recipient>
</award-group>
<funding-statement>The study was financially supported by the collaborative European Union's FP7 Research Projects -GUMS AND JOINTS (grant agreement number: FP7-HEALTH-2010-261460) and TRIGGER (grant agreement number: FP7-Health-2013-306029), the Stockholm County Council (SOF and ALF), the Swedish Research Council (VR), Karolinska Institutet, the Swedish Dental Society, and the Swedish Rheumatic Foundation. The funding was received by TYL, KL, LK, LA, and KE. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.</funding-statement>
</funding-group>
<counts><fig-count count="2"></fig-count>
<table-count count="4"></table-count>
<page-count count="16"></page-count>
</counts>
<custom-meta-group><custom-meta id="data-availability"><meta-name>Data Availability</meta-name>
<meta-value>All relevant data are within the paper and its Supporting Information files.</meta-value>
</custom-meta>
</custom-meta-group>
</article-meta>
<notes><title>Data Availability</title>
<p>All relevant data are within the paper and its Supporting Information files.</p>
</notes>
</front>
</pmc>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Santé/explor/EdenteV2/Data/Pmc/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000758 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Pmc/Curation/biblio.hfd -nk 000758 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Santé |area= EdenteV2 |flux= Pmc |étape= Curation |type= RBID |clé= PMC:4874595 |texte= Prevalence of Periodontitis in Patients with Established Rheumatoid Arthritis: A Swedish Population Based Case-Control Study }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Pmc/Curation/RBID.i -Sk "pubmed:27203435" \ | HfdSelect -Kh $EXPLOR_AREA/Data/Pmc/Curation/biblio.hfd \ | NlmPubMed2Wicri -a EdenteV2
![]() | This area was generated with Dilib version V0.6.32. | ![]() |