Salivary levels of interleukin-6 and tumor necrosis factor-α in patients undergoing hemodialysis
Identifieur interne : 000620 ( Pmc/Curation ); précédent : 000619; suivant : 000621Salivary levels of interleukin-6 and tumor necrosis factor-α in patients undergoing hemodialysis
Auteurs : Faezeh Khozeymeh [Iran] ; Mojgan Mortazavi [Iran] ; Navid Khalighinejad [Iran] ; Mehrdad Akhavankhaleghi [Iran] ; Milad Alikhani [Iran]Source :
- Dental Research Journal [ 1735-3327 ] ; 2016.
Abstract
Inflammatory cytokines such as interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-α) are elevated in end-stage renal disease (ESRD). IL-6 and TNF-α are toxins which deteriorate renal function, and their pathogenic role has been confirmed in cardiovascular and oral diseases. This study was designed to investigate the salivary levels of IL-6 and TNF-α in patients with ESRD undergoing hemodialysis (HD).
Twenty patients with ESRD who were treated with 4 h HD sessions, with low flux membrane were included in this cross-sectional study. Average Kt/V index in patients was 1.19 ± 0.1. Twenty age-sex-matched healthy controls with no infectious diseases during 1 month before saliva sampling were selected. Unstimulated whole saliva was collected and TNF-α and IL-6, concentrations were measured using human IL-6 and TNF-α ELISA kits. Independent
There was a significant difference between dialysis and control groups regarding the salivary levels of TNF-α (
Considering the results of this study and reported role of inflammatory cytokines in the pathogenesis of cardiovascular and oral diseases, measurement of salivary IL-6 and TNF-α in HD patients may help in risk stratification of HD patients and in planning pertinent preventive strategies.
Url:
DOI: 10.4103/1735-3327.174720
PubMed: 26962319
PubMed Central: 4770473
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Salivary levels of interleukin-6 and tumor necrosis factor-α in patients undergoing hemodialysis</title><author><name sortKey="Khozeymeh, Faezeh" sort="Khozeymeh, Faezeh" uniqKey="Khozeymeh F" first="Faezeh" last="Khozeymeh">Faezeh Khozeymeh</name><affiliation wicri:level="1"><nlm:aff id="aff1">Torabinejad Dental Research Center and Department of Oral Medicine, School of Dentistry, Isfahan University of Medical Sciences, Isfahan, Iran</nlm:aff><country xml:lang="fr">Iran</country><wicri:regionArea>Torabinejad Dental Research Center and Department of Oral Medicine, School of Dentistry, Isfahan University of Medical Sciences, Isfahan</wicri:regionArea></affiliation></author><author><name sortKey="Mortazavi, Mojgan" sort="Mortazavi, Mojgan" uniqKey="Mortazavi M" first="Mojgan" last="Mortazavi">Mojgan Mortazavi</name><affiliation wicri:level="1"><nlm:aff id="aff2">Department of Nephrology, Isfahan University of Medical Sciences, Isfahan, Iran</nlm:aff><country xml:lang="fr">Iran</country><wicri:regionArea>Department of Nephrology, Isfahan University of Medical Sciences, Isfahan</wicri:regionArea></affiliation></author><author><name sortKey="Khalighinejad, Navid" sort="Khalighinejad, Navid" uniqKey="Khalighinejad N" first="Navid" last="Khalighinejad">Navid Khalighinejad</name><affiliation wicri:level="1"><nlm:aff id="aff3">Torabinejad Dental Research Center, Isfahan University of Medical Sciences, Isfahan, Iran</nlm:aff><country xml:lang="fr">Iran</country><wicri:regionArea>Torabinejad Dental Research Center, Isfahan University of Medical Sciences, Isfahan</wicri:regionArea></affiliation></author><author><name sortKey="Akhavankhaleghi, Mehrdad" sort="Akhavankhaleghi, Mehrdad" uniqKey="Akhavankhaleghi M" first="Mehrdad" last="Akhavankhaleghi">Mehrdad Akhavankhaleghi</name><affiliation wicri:level="1"><nlm:aff id="aff3">Torabinejad Dental Research Center, Isfahan University of Medical Sciences, Isfahan, Iran</nlm:aff><country xml:lang="fr">Iran</country><wicri:regionArea>Torabinejad Dental Research Center, Isfahan University of Medical Sciences, Isfahan</wicri:regionArea></affiliation></author><author><name sortKey="Alikhani, Milad" sort="Alikhani, Milad" uniqKey="Alikhani M" first="Milad" last="Alikhani">Milad Alikhani</name><affiliation wicri:level="1"><nlm:aff id="aff1">Torabinejad Dental Research Center and Department of Oral Medicine, School of Dentistry, Isfahan University of Medical Sciences, Isfahan, Iran</nlm:aff><country xml:lang="fr">Iran</country><wicri:regionArea>Torabinejad Dental Research Center and Department of Oral Medicine, School of Dentistry, Isfahan University of Medical Sciences, Isfahan</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">26962319</idno><idno type="pmc">4770473</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4770473</idno><idno type="RBID">PMC:4770473</idno><idno type="doi">10.4103/1735-3327.174720</idno><date when="2016">2016</date><idno type="wicri:Area/Pmc/Corpus">000620</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000620</idno><idno type="wicri:Area/Pmc/Curation">000620</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000620</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Salivary levels of interleukin-6 and tumor necrosis factor-α in patients undergoing hemodialysis</title><author><name sortKey="Khozeymeh, Faezeh" sort="Khozeymeh, Faezeh" uniqKey="Khozeymeh F" first="Faezeh" last="Khozeymeh">Faezeh Khozeymeh</name><affiliation wicri:level="1"><nlm:aff id="aff1">Torabinejad Dental Research Center and Department of Oral Medicine, School of Dentistry, Isfahan University of Medical Sciences, Isfahan, Iran</nlm:aff><country xml:lang="fr">Iran</country><wicri:regionArea>Torabinejad Dental Research Center and Department of Oral Medicine, School of Dentistry, Isfahan University of Medical Sciences, Isfahan</wicri:regionArea></affiliation></author><author><name sortKey="Mortazavi, Mojgan" sort="Mortazavi, Mojgan" uniqKey="Mortazavi M" first="Mojgan" last="Mortazavi">Mojgan Mortazavi</name><affiliation wicri:level="1"><nlm:aff id="aff2">Department of Nephrology, Isfahan University of Medical Sciences, Isfahan, Iran</nlm:aff><country xml:lang="fr">Iran</country><wicri:regionArea>Department of Nephrology, Isfahan University of Medical Sciences, Isfahan</wicri:regionArea></affiliation></author><author><name sortKey="Khalighinejad, Navid" sort="Khalighinejad, Navid" uniqKey="Khalighinejad N" first="Navid" last="Khalighinejad">Navid Khalighinejad</name><affiliation wicri:level="1"><nlm:aff id="aff3">Torabinejad Dental Research Center, Isfahan University of Medical Sciences, Isfahan, Iran</nlm:aff><country xml:lang="fr">Iran</country><wicri:regionArea>Torabinejad Dental Research Center, Isfahan University of Medical Sciences, Isfahan</wicri:regionArea></affiliation></author><author><name sortKey="Akhavankhaleghi, Mehrdad" sort="Akhavankhaleghi, Mehrdad" uniqKey="Akhavankhaleghi M" first="Mehrdad" last="Akhavankhaleghi">Mehrdad Akhavankhaleghi</name><affiliation wicri:level="1"><nlm:aff id="aff3">Torabinejad Dental Research Center, Isfahan University of Medical Sciences, Isfahan, Iran</nlm:aff><country xml:lang="fr">Iran</country><wicri:regionArea>Torabinejad Dental Research Center, Isfahan University of Medical Sciences, Isfahan</wicri:regionArea></affiliation></author><author><name sortKey="Alikhani, Milad" sort="Alikhani, Milad" uniqKey="Alikhani M" first="Milad" last="Alikhani">Milad Alikhani</name><affiliation wicri:level="1"><nlm:aff id="aff1">Torabinejad Dental Research Center and Department of Oral Medicine, School of Dentistry, Isfahan University of Medical Sciences, Isfahan, Iran</nlm:aff><country xml:lang="fr">Iran</country><wicri:regionArea>Torabinejad Dental Research Center and Department of Oral Medicine, School of Dentistry, Isfahan University of Medical Sciences, Isfahan</wicri:regionArea></affiliation></author></analytic><series><title level="j">Dental Research Journal</title><idno type="ISSN">1735-3327</idno><idno type="eISSN">2008-0255</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="st1"><title>Background:</title><p>Inflammatory cytokines such as interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-α) are elevated in end-stage renal disease (ESRD). IL-6 and TNF-α are toxins which deteriorate renal function, and their pathogenic role has been confirmed in cardiovascular and oral diseases. This study was designed to investigate the salivary levels of IL-6 and TNF-α in patients with ESRD undergoing hemodialysis (HD).</p></sec><sec id="st2"><title>Materials and Methods:</title><p>Twenty patients with ESRD who were treated with 4 h HD sessions, with low flux membrane were included in this cross-sectional study. Average Kt/V index in patients was 1.19 ± 0.1. Twenty age-sex-matched healthy controls with no infectious diseases during 1 month before saliva sampling were selected. Unstimulated whole saliva was collected and TNF-α and IL-6, concentrations were measured using human IL-6 and TNF-α ELISA kits. Independent <italic>t</italic>-test was used to analyze the data using SPSS (α = 0.05).</p></sec><sec id="st3"><title>Results:</title><p>There was a significant difference between dialysis and control groups regarding the salivary levels of TNF-α (<italic>P</italic> = 0.034) and IL-6 (<italic>P</italic> = 0.001).</p></sec><sec id="st4"><title>Conclusion:</title><p>Considering the results of this study and reported role of inflammatory cytokines in the pathogenesis of cardiovascular and oral diseases, measurement of salivary IL-6 and TNF-α in HD patients may help in risk stratification of HD patients and in planning pertinent preventive strategies.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Fatahzadeh, M" uniqKey="Fatahzadeh M">M Fatahzadeh</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kausz, At" uniqKey="Kausz A">AT Kausz</name></author><author><name sortKey="Khan, Ss" uniqKey="Khan 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<front><journal-meta><journal-id journal-id-type="nlm-ta">Dent Res J (Isfahan)</journal-id><journal-id journal-id-type="iso-abbrev">Dent Res J (Isfahan)</journal-id><journal-id journal-id-type="publisher-id">DRJ</journal-id><journal-title-group><journal-title>Dental Research Journal</journal-title></journal-title-group><issn pub-type="ppub">1735-3327</issn><issn pub-type="epub">2008-0255</issn><publisher><publisher-name>Medknow Publications & Media Pvt Ltd</publisher-name><publisher-loc>India</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">26962319</article-id><article-id pub-id-type="pmc">4770473</article-id><article-id pub-id-type="publisher-id">DRJ-13-69</article-id><article-id pub-id-type="doi">10.4103/1735-3327.174720</article-id><article-categories><subj-group subj-group-type="heading"><subject>Original Article</subject></subj-group></article-categories><title-group><article-title>Salivary levels of interleukin-6 and tumor necrosis factor-α in patients undergoing hemodialysis</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Khozeymeh</surname><given-names>Faezeh</given-names></name><xref ref-type="aff" rid="aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Mortazavi</surname><given-names>Mojgan</given-names></name><xref ref-type="aff" rid="aff2">2</xref></contrib><contrib contrib-type="author"><name><surname>Khalighinejad</surname><given-names>Navid</given-names></name><xref ref-type="aff" rid="aff3">3</xref></contrib><contrib contrib-type="author"><name><surname>Akhavankhaleghi</surname><given-names>Mehrdad</given-names></name><xref ref-type="aff" rid="aff3">3</xref></contrib><contrib contrib-type="author"><name><surname>Alikhani</surname><given-names>Milad</given-names></name><xref ref-type="aff" rid="aff1">1</xref><xref ref-type="corresp" rid="cor1"></xref></contrib></contrib-group><aff id="aff1"><label>1</label>Torabinejad Dental Research Center and Department of Oral Medicine, School of Dentistry, Isfahan University of Medical Sciences, Isfahan, Iran</aff><aff id="aff2"><label>2</label>Department of Nephrology, Isfahan University of Medical Sciences, Isfahan, Iran</aff><aff id="aff3"><label>3</label>Torabinejad Dental Research Center, Isfahan University of Medical Sciences, Isfahan, Iran</aff><author-notes><corresp id="cor1"><bold>Address for correspondence:</bold> Dr. Milad Alikhani, Torabinejad Research Center, Isfahan University of Medical Sciences, Isfahan, Iran. E-mail: <email xlink:href="alikhanimilad.oralmedicine@yahoo.com">alikhanimilad.oralmedicine@yahoo.com</email></corresp></author-notes><pub-date pub-type="ppub"><season>Jan-Feb</season><year>2016</year></pub-date><volume>13</volume><issue>1</issue><fpage>69</fpage><lpage>73</lpage><history><date date-type="received"><month>4</month><year>2015</year></date><date date-type="accepted"><month>10</month><year>2015</year></date></history><permissions><copyright-statement>Copyright: © Dental Research Journal</copyright-statement><copyright-year>2016</copyright-year><license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by-nc-sa/3.0"><license-p>This is an open access article distributed under the terms of the Creative Commons Attribution NonCommercial ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non commercially, as long as the author is credited and the new creations are licensed under the identical terms.</license-p></license></permissions><abstract><sec id="st1"><title>Background:</title><p>Inflammatory cytokines such as interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-α) are elevated in end-stage renal disease (ESRD). IL-6 and TNF-α are toxins which deteriorate renal function, and their pathogenic role has been confirmed in cardiovascular and oral diseases. This study was designed to investigate the salivary levels of IL-6 and TNF-α in patients with ESRD undergoing hemodialysis (HD).</p></sec><sec id="st2"><title>Materials and Methods:</title><p>Twenty patients with ESRD who were treated with 4 h HD sessions, with low flux membrane were included in this cross-sectional study. Average Kt/V index in patients was 1.19 ± 0.1. Twenty age-sex-matched healthy controls with no infectious diseases during 1 month before saliva sampling were selected. Unstimulated whole saliva was collected and TNF-α and IL-6, concentrations were measured using human IL-6 and TNF-α ELISA kits. Independent <italic>t</italic>-test was used to analyze the data using SPSS (α = 0.05).</p></sec><sec id="st3"><title>Results:</title><p>There was a significant difference between dialysis and control groups regarding the salivary levels of TNF-α (<italic>P</italic> = 0.034) and IL-6 (<italic>P</italic> = 0.001).</p></sec><sec id="st4"><title>Conclusion:</title><p>Considering the results of this study and reported role of inflammatory cytokines in the pathogenesis of cardiovascular and oral diseases, measurement of salivary IL-6 and TNF-α in HD patients may help in risk stratification of HD patients and in planning pertinent preventive strategies.</p></sec></abstract><kwd-group><kwd>Cytokine</kwd><kwd>hemodialysis</kwd><kwd>renal failure</kwd><kwd>saliva</kwd></kwd-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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