Mandibular bone mineral density in patients with Behçet’s disease
Identifieur interne : 000444 ( Pmc/Curation ); précédent : 000443; suivant : 000445Mandibular bone mineral density in patients with Behçet’s disease
Auteurs : Fatih Asutay [Turquie] ; Yusuf Atalay [Turquie] ; Ahmet Hüseyin Acar [Turquie] ; Hilal Asutay [Turquie] ; Selma Ero Lu [Turquie] ; Muammer Ça R Burdurlu [Turquie]Source :
- Therapeutics and Clinical Risk Management [ 1176-6336 ] ; 2015.
Abstract
Behçet’s disease (BD) is a chronic, recurring vasculitis of unknown etiology. Patients with BD may use a lot of medications associated with the clinical symptoms. Drugs that are used in the treatment of BD may cause bone loss. The aims of the current study were to compare the bone mineral density (BMD) values between BD and healthy volunteers and describe the effect of disease duration on mandibular BMD.
The study comprised 30 healthy volunteers (15 males and 15 females, mean age 35.50±6.80 years) and 45 patients with BD (24 males and 21 females, mean age 38.93±8.93 years). The BD group was subdivided according to disease duration (0–5, 6–10, and >10 years). The BMD value of the mandibular body was determined by the dual energy X-ray absorptiometry technique.
The mean mandibular body BMD values were 1.294±0.21 g/cm2 in the control group and 1.216±0.22 g/cm2 in the BD patients, although there was no statistically significant difference. The BMD was observed to decrease with increased disease duration but not to a statistically significant degree.
The results of this study showed that although the BMD value decreased as the duration of the disease increased, no statistically significant difference was found between the BD patients and the healthy control group.
Url:
DOI: 10.2147/TCRM.S93286
PubMed: 26508868
PubMed Central: 4610776
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Afyonkarahisar, Turkey</nlm:aff><country xml:lang="fr">Turquie</country><wicri:regionArea>Department of Prosthodontics, Faculty of Dentistry, Afyon Kocatepe University, Afyonkarahisar</wicri:regionArea></affiliation></author><author><name sortKey="Ero Lu, Selma" sort="Ero Lu, Selma" uniqKey="Ero Lu S" first="Selma" last="Ero Lu">Selma Ero Lu</name><affiliation wicri:level="1"><nlm:aff id="af4-tcrm-11-1587">Department of Physical Therapy and Rehabilitation, Faculty of Medicine, Afyon Kocatepe University, Afyonkarahisar, Turkey</nlm:aff><country xml:lang="fr">Turquie</country><wicri:regionArea>Department of Physical Therapy and Rehabilitation, Faculty of Medicine, Afyon Kocatepe University, Afyonkarahisar</wicri:regionArea></affiliation></author><author><name sortKey="Burdurlu, Muammer Ca R" sort="Burdurlu, Muammer Ca R" uniqKey="Burdurlu M" first="Muammer Ça R" last="Burdurlu">Muammer Ça R Burdurlu</name><affiliation wicri:level="1"><nlm:aff id="af5-tcrm-11-1587">Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Yeditepe University, Istanbul, Turkey</nlm:aff><country xml:lang="fr">Turquie</country><wicri:regionArea>Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Yeditepe University, Istanbul</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">26508868</idno><idno type="pmc">4610776</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4610776</idno><idno type="RBID">PMC:4610776</idno><idno type="doi">10.2147/TCRM.S93286</idno><date when="2015">2015</date><idno type="wicri:Area/Pmc/Corpus">000444</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000444</idno><idno type="wicri:Area/Pmc/Curation">000444</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000444</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Mandibular bone mineral density in patients with Behçet’s disease</title><author><name sortKey="Asutay, Fatih" sort="Asutay, Fatih" uniqKey="Asutay F" first="Fatih" last="Asutay">Fatih Asutay</name><affiliation wicri:level="1"><nlm:aff id="af1-tcrm-11-1587">Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Afyon Kocatepe University, Afyonkarahisar, Turkey</nlm:aff><country xml:lang="fr">Turquie</country><wicri:regionArea>Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Afyon Kocatepe University, Afyonkarahisar</wicri:regionArea></affiliation></author><author><name sortKey="Atalay, Yusuf" sort="Atalay, Yusuf" uniqKey="Atalay Y" first="Yusuf" last="Atalay">Yusuf Atalay</name><affiliation wicri:level="1"><nlm:aff id="af1-tcrm-11-1587">Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Afyon Kocatepe University, Afyonkarahisar, Turkey</nlm:aff><country xml:lang="fr">Turquie</country><wicri:regionArea>Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Afyon Kocatepe University, Afyonkarahisar</wicri:regionArea></affiliation></author><author><name sortKey="Acar, Ahmet Huseyin" sort="Acar, Ahmet Huseyin" uniqKey="Acar A" first="Ahmet Hüseyin" last="Acar">Ahmet Hüseyin Acar</name><affiliation wicri:level="1"><nlm:aff id="af2-tcrm-11-1587">Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Bezmialem Vakıf University, Istanbul, Turkey</nlm:aff><country xml:lang="fr">Turquie</country><wicri:regionArea>Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Bezmialem Vakıf University, Istanbul</wicri:regionArea></affiliation></author><author><name sortKey="Asutay, Hilal" sort="Asutay, Hilal" uniqKey="Asutay H" first="Hilal" last="Asutay">Hilal Asutay</name><affiliation wicri:level="1"><nlm:aff id="af3-tcrm-11-1587">Department of Prosthodontics, Faculty of Dentistry, Afyon Kocatepe University, Afyonkarahisar, Turkey</nlm:aff><country xml:lang="fr">Turquie</country><wicri:regionArea>Department of Prosthodontics, Faculty of Dentistry, Afyon Kocatepe University, Afyonkarahisar</wicri:regionArea></affiliation></author><author><name sortKey="Ero Lu, Selma" sort="Ero Lu, Selma" uniqKey="Ero Lu S" first="Selma" last="Ero Lu">Selma Ero Lu</name><affiliation wicri:level="1"><nlm:aff id="af4-tcrm-11-1587">Department of Physical Therapy and Rehabilitation, Faculty of Medicine, Afyon Kocatepe University, Afyonkarahisar, Turkey</nlm:aff><country xml:lang="fr">Turquie</country><wicri:regionArea>Department of Physical Therapy and Rehabilitation, Faculty of Medicine, Afyon Kocatepe University, Afyonkarahisar</wicri:regionArea></affiliation></author><author><name sortKey="Burdurlu, Muammer Ca R" sort="Burdurlu, Muammer Ca R" uniqKey="Burdurlu M" first="Muammer Ça R" last="Burdurlu">Muammer Ça R Burdurlu</name><affiliation wicri:level="1"><nlm:aff id="af5-tcrm-11-1587">Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Yeditepe University, Istanbul, Turkey</nlm:aff><country xml:lang="fr">Turquie</country><wicri:regionArea>Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Yeditepe University, Istanbul</wicri:regionArea></affiliation></author></analytic><series><title level="j">Therapeutics and Clinical Risk Management</title><idno type="ISSN">1176-6336</idno><idno type="eISSN">1178-203X</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Objectives</title><p>Behçet’s disease (BD) is a chronic, recurring vasculitis of unknown etiology. Patients with BD may use a lot of medications associated with the clinical symptoms. Drugs that are used in the treatment of BD may cause bone loss. The aims of the current study were to compare the bone mineral density (BMD) values between BD and healthy volunteers and describe the effect of disease duration on mandibular BMD.</p></sec><sec><title>Materials and methods</title><p>The study comprised 30 healthy volunteers (15 males and 15 females, mean age 35.50±6.80 years) and 45 patients with BD (24 males and 21 females, mean age 38.93±8.93 years). The BD group was subdivided according to disease duration (0–5, 6–10, and >10 years). The BMD value of the mandibular body was determined by the dual energy X-ray absorptiometry technique.</p></sec><sec><title>Results</title><p>The mean mandibular body BMD values were 1.294±0.21 g/cm<sup>2</sup> in the control group and 1.216±0.22 g/cm<sup>2</sup> in the BD patients, although there was no statistically significant difference. The BMD was observed to decrease with increased disease duration but not to a statistically significant degree.</p></sec><sec><title>Conclusion</title><p>The results of this study showed that although the BMD value decreased as the duration of the disease increased, no statistically significant difference was found between the BD patients and the healthy control group.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Saleh, Z" uniqKey="Saleh Z">Z Saleh</name></author><author><name sortKey="Arayssi, T" uniqKey="Arayssi T">T Arayssi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rigante, D" uniqKey="Rigante D">D Rigante</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tekin, Ns" uniqKey="Tekin N">NS Tekin</name></author><author><name sortKey="Ozdolap, S" uniqKey="Ozdolap S">S Ozdolap</name></author><author><name sortKey="Sarikaya, S" uniqKey="Sarikaya S">S 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<front><journal-meta><journal-id journal-id-type="nlm-ta">Ther Clin Risk Manag</journal-id><journal-id journal-id-type="iso-abbrev">Ther Clin Risk Manag</journal-id><journal-id journal-id-type="publisher-id">Therapeutics and Clinical Risk Management</journal-id><journal-title-group><journal-title>Therapeutics and Clinical Risk Management</journal-title></journal-title-group><issn pub-type="ppub">1176-6336</issn><issn pub-type="epub">1178-203X</issn><publisher><publisher-name>Dove Medical Press</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">26508868</article-id><article-id pub-id-type="pmc">4610776</article-id><article-id pub-id-type="doi">10.2147/TCRM.S93286</article-id><article-id pub-id-type="publisher-id">tcrm-11-1587</article-id><article-categories><subj-group subj-group-type="heading"><subject>Original Research</subject></subj-group></article-categories><title-group><article-title>Mandibular bone mineral density in patients with Behçet’s disease</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Asutay</surname><given-names>Fatih</given-names></name><xref ref-type="aff" rid="af1-tcrm-11-1587">1</xref><xref ref-type="corresp" rid="c1-tcrm-11-1587"></xref></contrib><contrib contrib-type="author"><name><surname>Atalay</surname><given-names>Yusuf</given-names></name><xref ref-type="aff" rid="af1-tcrm-11-1587">1</xref></contrib><contrib contrib-type="author"><name><surname>Acar</surname><given-names>Ahmet Hüseyin</given-names></name><xref ref-type="aff" rid="af2-tcrm-11-1587">2</xref></contrib><contrib contrib-type="author"><name><surname>Asutay</surname><given-names>Hilal</given-names></name><xref ref-type="aff" rid="af3-tcrm-11-1587">3</xref></contrib><contrib contrib-type="author"><name><surname>Eroğlu</surname><given-names>Selma</given-names></name><xref ref-type="aff" rid="af4-tcrm-11-1587">4</xref></contrib><contrib contrib-type="author"><name><surname>Burdurlu</surname><given-names>Muammer Çağrı</given-names></name><xref ref-type="aff" rid="af5-tcrm-11-1587">5</xref></contrib></contrib-group><aff id="af1-tcrm-11-1587"><label>1</label>Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Afyon Kocatepe University, Afyonkarahisar, Turkey</aff><aff id="af2-tcrm-11-1587"><label>2</label>Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Bezmialem Vakıf University, Istanbul, Turkey</aff><aff id="af3-tcrm-11-1587"><label>3</label>Department of Prosthodontics, Faculty of Dentistry, Afyon Kocatepe University, Afyonkarahisar, Turkey</aff><aff id="af4-tcrm-11-1587"><label>4</label>Department of Physical Therapy and Rehabilitation, Faculty of Medicine, Afyon Kocatepe University, Afyonkarahisar, Turkey</aff><aff id="af5-tcrm-11-1587"><label>5</label>Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Yeditepe University, Istanbul, Turkey</aff><author-notes><corresp id="c1-tcrm-11-1587">Correspondence: Fatih Asutay, Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Afyon Kocatepe University, Guvenevler Street Inonu Boulevard No 4, 03030 Afyonkarahisar, Turkey, Tel +90 272 216 7900 ext 1038, Email <email>dt_asutay@hotmail.com</email></corresp></author-notes><pub-date pub-type="collection"><year>2015</year></pub-date><pub-date pub-type="epub"><day>14</day><month>10</month><year>2015</year></pub-date><volume>11</volume><fpage>1587</fpage><lpage>1591</lpage><permissions><copyright-statement>© 2015 Asutay et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License</copyright-statement><copyright-year>2015</copyright-year><license><license-p>The full terms of the License are available at <ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by-nc/3.0/">http://creativecommons.org/licenses/by-nc/3.0/</ext-link>. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.</license-p></license></permissions><abstract><sec><title>Objectives</title><p>Behçet’s disease (BD) is a chronic, recurring vasculitis of unknown etiology. Patients with BD may use a lot of medications associated with the clinical symptoms. Drugs that are used in the treatment of BD may cause bone loss. The aims of the current study were to compare the bone mineral density (BMD) values between BD and healthy volunteers and describe the effect of disease duration on mandibular BMD.</p></sec><sec><title>Materials and methods</title><p>The study comprised 30 healthy volunteers (15 males and 15 females, mean age 35.50±6.80 years) and 45 patients with BD (24 males and 21 females, mean age 38.93±8.93 years). The BD group was subdivided according to disease duration (0–5, 6–10, and >10 years). The BMD value of the mandibular body was determined by the dual energy X-ray absorptiometry technique.</p></sec><sec><title>Results</title><p>The mean mandibular body BMD values were 1.294±0.21 g/cm<sup>2</sup> in the control group and 1.216±0.22 g/cm<sup>2</sup> in the BD patients, although there was no statistically significant difference. The BMD was observed to decrease with increased disease duration but not to a statistically significant degree.</p></sec><sec><title>Conclusion</title><p>The results of this study showed that although the BMD value decreased as the duration of the disease increased, no statistically significant difference was found between the BD patients and the healthy control group.</p></sec></abstract><kwd-group><title>Keywords</title><kwd>Behçet’s disease</kwd><kwd>mandible</kwd><kwd>bone mineral density</kwd><kwd>dual energy X-ray absorptiometry</kwd></kwd-group></article-meta></front><floats-group><fig id="f1-tcrm-11-1587" position="float"><label>Figure 1</label><caption><p>Measurement of mandibular BMD by dual-energy X-ray absorptiometry.</p><p><bold>Abbreviation:</bold> BMD, bone mineral density.</p></caption><graphic xlink:href="tcrm-11-1587Fig1"></graphic></fig><table-wrap id="t1-tcrm-11-1587" position="float"><label>Table 1</label><caption><p>Characteristics of patients (all groups) according to age, BMI, and BMD</p></caption><table frame="hsides" rules="groups"><thead><tr><th valign="top" align="left" rowspan="1" colspan="1">Characteristics</th><th valign="top" align="left" rowspan="1" colspan="1">Age</th><th valign="top" align="left" rowspan="1" colspan="1">BMI (kg/m<sup>2</sup>)</th><th valign="top" align="left" rowspan="1" colspan="1">BMD (g/cm<sup>2</sup>)</th></tr></thead><tbody><tr><td valign="top" align="left" rowspan="1" colspan="1">Group 1 (controls)</td><td valign="top" align="left" rowspan="1" colspan="1">35.5±6.8 (22–45)</td><td valign="top" align="left" rowspan="1" colspan="1">28.20±4.7 (19.3–37.5)</td><td valign="top" align="left" rowspan="1" colspan="1">1.294±0.21 (0.86–1.71)</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1">Group 2 (0–5 years)</td><td valign="top" align="left" rowspan="1" colspan="1">33.67±6.5 (23–44)</td><td valign="top" align="left" rowspan="1" colspan="1">27.49±5.7 (17.1–39.3)</td><td valign="top" align="left" rowspan="1" colspan="1">1.251±0.22 (0.83–1.55)</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1">Group 3 (5–10 years)</td><td valign="top" align="left" rowspan="1" colspan="1">35.87±6.0 (27–45)</td><td valign="top" align="left" rowspan="1" colspan="1">24.90±3.5 (19.4–32.5)</td><td valign="top" align="left" rowspan="1" colspan="1">1.249±0.20 (0.83–1.52)</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1">Group 4 (+10 years)</td><td valign="top" align="left" rowspan="1" colspan="1">47.27±7.5 (34–63)</td><td valign="top" align="left" rowspan="1" colspan="1">26.85±4.2 (21.1–34.4)</td><td valign="top" align="left" rowspan="1" colspan="1">1.147±0.24 (0.79–1.57)</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1">Total</td><td valign="top" align="left" rowspan="1" colspan="1">37.56±8.2 (22–63)</td><td valign="top" align="left" rowspan="1" colspan="1">27.12±4.7 (17.1–39.3)</td><td valign="top" align="left" rowspan="1" colspan="1">1.247±0.22 (0.79–1.71)</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1"><italic>P</italic>-values<xref ref-type="table-fn" rid="tfn1-tcrm-11-1587">*</xref></td><td valign="top" align="left" rowspan="1" colspan="1">0.000</td><td valign="top" align="left" rowspan="1" colspan="1">0.167</td><td valign="top" align="left" rowspan="1" colspan="1">0.228</td></tr></tbody></table><table-wrap-foot><fn><p><bold>Notes:</bold></p></fn><fn id="tfn1-tcrm-11-1587"><label>*</label><p>One-way ANOVA test, Tukey HSD. Data are represented as mean ± standard deviation.</p></fn><fn id="tfn2-tcrm-11-1587"><p><bold>Abbreviations:</bold> ANOVA, analysis of variance; BMD, bone mineral density; BMI, body mass index; HSD, honest significant difference.</p></fn></table-wrap-foot></table-wrap><table-wrap id="t2-tcrm-11-1587" position="float"><label>Table 2</label><caption><p>Characteristics of patients (all Behçet’s patients and controls) according to age, BMI, and BMD</p></caption><table frame="hsides" rules="groups"><thead><tr><th valign="top" align="left" rowspan="1" colspan="1">Characteristics</th><th valign="top" align="left" rowspan="1" colspan="1">Age</th><th valign="top" align="left" rowspan="1" colspan="1">BMI (kg/m<sup>2</sup>)</th><th valign="top" align="left" rowspan="1" colspan="1">BMD (g/cm<sup>2</sup>)</th></tr></thead><tbody><tr><td valign="top" align="left" rowspan="1" colspan="1">All Behçet’s patients</td><td valign="top" align="left" rowspan="1" colspan="1">38.93±8.93</td><td valign="top" align="left" rowspan="1" colspan="1">26.4±4.6</td><td valign="top" align="left" rowspan="1" colspan="1">1.216±0.22</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1">Controls</td><td valign="top" align="left" rowspan="1" colspan="1">35.50±6.80</td><td valign="top" align="left" rowspan="1" colspan="1">28.2±4.7</td><td valign="top" align="left" rowspan="1" colspan="1">1.294±0.21</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1">Total</td><td valign="top" align="left" rowspan="1" colspan="1">37.56±8.2</td><td valign="top" align="left" rowspan="1" colspan="1">27.12±4.7</td><td valign="top" align="left" rowspan="1" colspan="1">1.247±0.22</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1"><italic>P</italic>-value<xref ref-type="table-fn" rid="tfn3-tcrm-11-1587">*</xref></td><td valign="top" align="left" rowspan="1" colspan="1">0.078</td><td valign="top" align="left" rowspan="1" colspan="1">0.108</td><td valign="top" align="left" rowspan="1" colspan="1">0.139</td></tr></tbody></table><table-wrap-foot><fn><p><bold>Note:</bold></p></fn><fn id="tfn3-tcrm-11-1587"><label>*</label><p>Student’s <italic>t</italic>-test.</p></fn><fn id="tfn4-tcrm-11-1587"><p><bold>Abbreviations:</bold> BMD, bone mineral density; BMI, body mass index.</p></fn></table-wrap-foot></table-wrap></floats-group></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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