Interruption of Electrical Conductivity of Titanium Dental Implants Suggests a Path Towards Elimination Of Corrosion
Identifieur interne : 000423 ( Pmc/Curation ); précédent : 000422; suivant : 000424Interruption of Electrical Conductivity of Titanium Dental Implants Suggests a Path Towards Elimination Of Corrosion
Auteurs : Alex E. Pozhitkov [États-Unis] ; Diane Daubert [États-Unis] ; Ashley Brochwicz Donimirski [États-Unis] ; Douglas Goodgion [États-Unis] ; Mikhail Y. Vagin [Suède] ; Brian G. Leroux [États-Unis] ; Colby M. Hunter [États-Unis] ; Thomas F. Flemmig [République populaire de Chine] ; Peter A. Noble [États-Unis] ; James D. Bryers [États-Unis]Source :
- PLoS ONE [ 1932-6203 ] ; 2015.
Abstract
Peri-implantitis is an inflammatory disease that results in the destruction of soft tissue and bone around the implant. Titanium implant corrosion has been attributed to the implant failure and cytotoxic effects to the alveolar bone. We have documented the extent of titanium release into surrounding plaque in patients with and without peri-implantitis. An
Url:
DOI: 10.1371/journal.pone.0140393
PubMed: 26461491
PubMed Central: 4604158
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<front><div type="abstract" xml:lang="en"><p>Peri-implantitis is an inflammatory disease that results in the destruction of soft tissue and bone around the implant. Titanium implant corrosion has been attributed to the implant failure and cytotoxic effects to the alveolar bone. We have documented the extent of titanium release into surrounding plaque in patients with and without peri-implantitis. An <italic>in vitro</italic>
model was designed to represent the actual environment of an implant in a patient’s mouth. The model uses actual oral microbiota from a volunteer, allows monitoring electrochemical processes generated by biofilms growing on implants and permits control of biocorrosion electrical current. As determined by next generation DNA sequencing, microbial compositions in experiments with the <italic>in vitro</italic>
model were comparable with the compositions found in patients with implants. It was determined that the electrical conductivity of titanium implants was the key factor responsible for the biocorrosion process. The interruption of the biocorrosion current resulted in a 4–5 fold reduction of corrosion. We propose a new design of dental implant that combines titanium in zero oxidation state for osseointegration and strength, interlaid with a nonconductive ceramic. In addition, we propose electrotherapy for manipulation of microbial biofilms and to induce bone healing in peri-implantitis patients.</p>
</div>
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<pmc article-type="research-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">PLoS One</journal-id>
<journal-id journal-id-type="iso-abbrev">PLoS ONE</journal-id>
<journal-id journal-id-type="publisher-id">plos</journal-id>
<journal-id journal-id-type="pmc">plosone</journal-id>
<journal-title-group><journal-title>PLoS ONE</journal-title>
</journal-title-group>
<issn pub-type="epub">1932-6203</issn>
<publisher><publisher-name>Public Library of Science</publisher-name>
<publisher-loc>San Francisco, CA USA</publisher-loc>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">26461491</article-id>
<article-id pub-id-type="pmc">4604158</article-id>
<article-id pub-id-type="doi">10.1371/journal.pone.0140393</article-id>
<article-id pub-id-type="publisher-id">PONE-D-15-29137</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject>
</subj-group>
</article-categories>
<title-group><article-title>Interruption of Electrical Conductivity of Titanium Dental Implants Suggests a Path Towards Elimination Of Corrosion</article-title>
<alt-title alt-title-type="running-head">Titanium Dental Implant Conductivity and Elimination of Corrosion</alt-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Pozhitkov</surname>
<given-names>Alex E.</given-names>
</name>
<xref ref-type="aff" rid="aff001"><sup>1</sup>
</xref>
<xref rid="cor001" ref-type="corresp">*</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Daubert</surname>
<given-names>Diane</given-names>
</name>
<xref ref-type="aff" rid="aff002"><sup>2</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Brochwicz Donimirski</surname>
<given-names>Ashley</given-names>
</name>
<xref ref-type="aff" rid="aff001"><sup>1</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Goodgion</surname>
<given-names>Douglas</given-names>
</name>
<xref ref-type="aff" rid="aff001"><sup>1</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Vagin</surname>
<given-names>Mikhail Y.</given-names>
</name>
<xref ref-type="aff" rid="aff003"><sup>3</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Leroux</surname>
<given-names>Brian G.</given-names>
</name>
<xref ref-type="aff" rid="aff001"><sup>1</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Hunter</surname>
<given-names>Colby M.</given-names>
</name>
<xref ref-type="aff" rid="aff004"><sup>4</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Flemmig</surname>
<given-names>Thomas F.</given-names>
</name>
<xref ref-type="aff" rid="aff005"><sup>5</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Noble</surname>
<given-names>Peter A.</given-names>
</name>
<xref ref-type="aff" rid="aff004"><sup>4</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Bryers</surname>
<given-names>James D.</given-names>
</name>
<xref ref-type="aff" rid="aff006"><sup>6</sup>
</xref>
</contrib>
</contrib-group>
<aff id="aff001"><label>1</label>
<addr-line>Department of Oral Health Sciences, University of Washington, Box 357444, Seattle, Washington, United States of America</addr-line>
</aff>
<aff id="aff002"><label>2</label>
<addr-line>Department of Periodontics, University of Washington, Box 357444, Seattle, Washington, United States of America</addr-line>
</aff>
<aff id="aff003"><label>3</label>
<addr-line>Department of Physics, Chemistry and Biology (IFM) Linköping University, SE-581 83, LINKÖPING, Sweden</addr-line>
</aff>
<aff id="aff004"><label>4</label>
<addr-line>PhD Program in Microbiology, Alabama State University, Montgomery, Alabama, United States of America</addr-line>
</aff>
<aff id="aff005"><label>5</label>
<addr-line>Faculty of Dentistry, The University of Hong Kong, Prince Philip Dental Hospital, 34 Hospital Road, Sai Ying Pun, Hong Kong SAR, Peoples’ Republic of China</addr-line>
</aff>
<aff id="aff006"><label>6</label>
<addr-line>Department of Bioengineering, University of Washington, 3720 15th Avenue NE, Seattle, Washington, United States of America</addr-line>
</aff>
<contrib-group><contrib contrib-type="editor"><name><surname>Pérez</surname>
<given-names>M. A.</given-names>
</name>
<role>Editor</role>
<xref ref-type="aff" rid="edit1"></xref>
</contrib>
</contrib-group>
<aff id="edit1"><addr-line>University of Zaragoza, SPAIN</addr-line>
</aff>
<author-notes><fn fn-type="conflict" id="coi001"><p><bold>Competing Interests: </bold>
The authors have declared that no competing interests exist.</p>
</fn>
<fn fn-type="con" id="contrib001"><p>Conceived and designed the experiments: AEP ABD DG TFF. Performed the experiments: AEP ABD DG PAN CH DD. Analyzed the data: AEP PAN BGL. Contributed reagents/materials/analysis tools: JDB. Wrote the paper: AEP JDB ABD MYV.</p>
</fn>
<corresp id="cor001">* E-mail: <email>pozhit@uw.edu</email>
</corresp>
</author-notes>
<pub-date pub-type="epub"><day>13</day>
<month>10</month>
<year>2015</year>
</pub-date>
<pub-date pub-type="collection"><year>2015</year>
</pub-date>
<volume>10</volume>
<issue>10</issue>
<elocation-id>e0140393</elocation-id>
<history><date date-type="received"><day>2</day>
<month>7</month>
<year>2015</year>
</date>
<date date-type="accepted"><day>24</day>
<month>9</month>
<year>2015</year>
</date>
</history>
<permissions><copyright-year>2015</copyright-year>
<copyright-holder>Pozhitkov et al</copyright-holder>
<license xlink:href="http://creativecommons.org/licenses/by/4.0/"><license-p>This is an open access article distributed under the terms of the <ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by/4.0/">Creative Commons Attribution License</ext-link>
, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited</license-p>
</license>
</permissions>
<self-uri content-type="pdf" xlink:type="simple" xlink:href="pone.0140393.pdf"></self-uri>
<abstract><p>Peri-implantitis is an inflammatory disease that results in the destruction of soft tissue and bone around the implant. Titanium implant corrosion has been attributed to the implant failure and cytotoxic effects to the alveolar bone. We have documented the extent of titanium release into surrounding plaque in patients with and without peri-implantitis. An <italic>in vitro</italic>
model was designed to represent the actual environment of an implant in a patient’s mouth. The model uses actual oral microbiota from a volunteer, allows monitoring electrochemical processes generated by biofilms growing on implants and permits control of biocorrosion electrical current. As determined by next generation DNA sequencing, microbial compositions in experiments with the <italic>in vitro</italic>
model were comparable with the compositions found in patients with implants. It was determined that the electrical conductivity of titanium implants was the key factor responsible for the biocorrosion process. The interruption of the biocorrosion current resulted in a 4–5 fold reduction of corrosion. We propose a new design of dental implant that combines titanium in zero oxidation state for osseointegration and strength, interlaid with a nonconductive ceramic. In addition, we propose electrotherapy for manipulation of microbial biofilms and to induce bone healing in peri-implantitis patients.</p>
</abstract>
<funding-group><funding-statement>AEP received a training grant from the National Institutes of Health (grant number 5 T90 D021984-03) and funding from the International Team for Implantology (grant number 954_2013). PAN received funding from the National Science Foundation, which was used to purchase the 454 sequencer. The international team for Implantology reviewed and approved the study design before issuing the funding.</funding-statement>
</funding-group>
<counts><fig-count count="6"></fig-count>
<table-count count="1"></table-count>
<page-count count="17"></page-count>
</counts>
<custom-meta-group><custom-meta id="data-availability"><meta-name>Data Availability</meta-name>
<meta-value>All relevant data are within the paper and its Supporting Information files.</meta-value>
</custom-meta>
</custom-meta-group>
</article-meta>
<notes><title>Data Availability</title>
<p>All relevant data are within the paper and its Supporting Information files.</p>
</notes>
</front>
</pmc>
</record>
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