Major Adverse Cardiovascular Events in Treated Periodontitis: A Population-Based Follow-Up Study from Taiwan
Identifieur interne : 000417 ( Pmc/Curation ); précédent : 000416; suivant : 000418Major Adverse Cardiovascular Events in Treated Periodontitis: A Population-Based Follow-Up Study from Taiwan
Auteurs : Shing-Hsien Chou [Taïwan] ; Ying-Chang Tung [Taïwan] ; Yu-Sheng Lin [Taïwan] ; Lung-Sheng Wu [Taïwan] ; Chia-Pin Lin [Taïwan] ; Eric Jein-Wein Liou [Taïwan] ; Chee-Jen Chang [Taïwan] ; Suefang Kung [Taïwan] ; Pao-Hsien Chu [Taïwan]Source :
- PLoS ONE [ 1932-6203 ] ; 2015.
Abstract
The aim of the present study was to identify the long-term major adverse cardiovascular events (MACE) in treated periodontitis patients in Taiwan.
From the National Health Insurance Research Database (2001-2010), adult patients (≥ 18 years) with treated periodontitis were identified. Comparison was made between patients with mild form and severe form of treated periodontitis after propensity score matching. The primary end point was the incidence of MACE.
A total of 32,504 adult patients with treated periodontitis were identified between 2001 and 2010. After propensity score matching, 27,146 patients were preserved for comparison, including 13,573 patients with mild form and 13,573 patients with severe form of treated periodontitis. During follow-up, 728 individuals in mild treated periodontitis group and 1,206 individuals in severe treated periodontitis group had at least 1 MACE event. After adjustment for gender, hyperlipidemia, hypertension and diabetes mellitus, severe treated periodontitis was associated with a mildly but significantly increased risk of MACE among older patients > 60 years of age (incidence rate ratio, 1.26; 95% confidence interval, 1.08–1.46). No association was found among younger patients ≤ 60 years of age.
Severe form of treated periodontitis was associated with an increased risk of MACE among older Taiwanese patients, but not among younger Taiwanese patients. We should put more efforts on the improvement of periodontal health to prevent further MACE.
Url:
DOI: 10.1371/journal.pone.0130807
PubMed: 26114433
PubMed Central: 4482590
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<front><div type="abstract" xml:lang="en"><sec id="sec001"><title>Background</title>
<p>The aim of the present study was to identify the long-term major adverse cardiovascular events (MACE) in treated periodontitis patients in Taiwan.</p>
</sec>
<sec id="sec002"><title>Methods</title>
<p>From the National Health Insurance Research Database (2001-2010), adult patients (≥ 18 years) with treated periodontitis were identified. Comparison was made between patients with mild form and severe form of treated periodontitis after propensity score matching. The primary end point was the incidence of MACE.</p>
</sec>
<sec id="sec003"><title>Results</title>
<p>A total of 32,504 adult patients with treated periodontitis were identified between 2001 and 2010. After propensity score matching, 27,146 patients were preserved for comparison, including 13,573 patients with mild form and 13,573 patients with severe form of treated periodontitis. During follow-up, 728 individuals in mild treated periodontitis group and 1,206 individuals in severe treated periodontitis group had at least 1 MACE event. After adjustment for gender, hyperlipidemia, hypertension and diabetes mellitus, severe treated periodontitis was associated with a mildly but significantly increased risk of MACE among older patients > 60 years of age (incidence rate ratio, 1.26; 95% confidence interval, 1.08–1.46). No association was found among younger patients ≤ 60 years of age.</p>
</sec>
<sec id="sec004"><title>Conclusions</title>
<p>Severe form of treated periodontitis was associated with an increased risk of MACE among older Taiwanese patients, but not among younger Taiwanese patients. We should put more efforts on the improvement of periodontal health to prevent further MACE.</p>
</sec>
</div>
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<back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Go, As" uniqKey="Go A">AS Go</name>
</author>
<author><name sortKey="Mozaffarian, D" uniqKey="Mozaffarian D">D Mozaffarian</name>
</author>
<author><name sortKey="Roger, Vl" uniqKey="Roger V">VL Roger</name>
</author>
<author><name sortKey="Benjamin, Ej" uniqKey="Benjamin E">EJ Benjamin</name>
</author>
<author><name sortKey="Berry, Jd" uniqKey="Berry J">JD Berry</name>
</author>
<author><name sortKey="Blaha, Mj" uniqKey="Blaha M">MJ Blaha</name>
</author>
</analytic>
</biblStruct>
<biblStruct></biblStruct>
<biblStruct><analytic><author><name sortKey="Ridker, Pm" uniqKey="Ridker P">PM Ridker</name>
</author>
<author><name sortKey="Hennekens, Ch" uniqKey="Hennekens C">CH Hennekens</name>
</author>
<author><name sortKey="Buring, Je" uniqKey="Buring J">JE Buring</name>
</author>
<author><name sortKey="Rifai, N" uniqKey="Rifai N">N Rifai</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Danesh, J" uniqKey="Danesh J">J Danesh</name>
</author>
<author><name sortKey="Whincup, P" uniqKey="Whincup P">P Whincup</name>
</author>
<author><name sortKey="Walker, M" uniqKey="Walker M">M Walker</name>
</author>
<author><name sortKey="Lennon, L" uniqKey="Lennon L">L Lennon</name>
</author>
<author><name sortKey="Thomson, A" uniqKey="Thomson A">A Thomson</name>
</author>
<author><name sortKey="Appleby, P" uniqKey="Appleby P">P Appleby</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Libby, P" uniqKey="Libby P">P Libby</name>
</author>
<author><name sortKey="Ridker, Pm" uniqKey="Ridker P">PM Ridker</name>
</author>
<author><name sortKey="Maseri, A" uniqKey="Maseri A">A Maseri</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hansson, Gk" uniqKey="Hansson G">GK Hansson</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Libby, P" uniqKey="Libby P">P Libby</name>
</author>
<author><name sortKey="Ridker, Pm" uniqKey="Ridker P">PM Ridker</name>
</author>
<author><name sortKey="Hansson, Gk" uniqKey="Hansson G">GK Hansson</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kaptoge, S" uniqKey="Kaptoge S">S Kaptoge</name>
</author>
<author><name sortKey="Di Angelantonio, E" uniqKey="Di Angelantonio E">E Di Angelantonio</name>
</author>
<author><name sortKey="Lowe, G" uniqKey="Lowe G">G Lowe</name>
</author>
<author><name sortKey="Pepys, Mb" uniqKey="Pepys M">MB Pepys</name>
</author>
<author><name sortKey="Thompson, Sg" uniqKey="Thompson S">SG Thompson</name>
</author>
<author><name sortKey="Collins, R" uniqKey="Collins R">R Collins</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="De Oliveira, C" uniqKey="De Oliveira C">C de Oliveira</name>
</author>
<author><name sortKey="Watt, R" uniqKey="Watt R">R Watt</name>
</author>
<author><name sortKey="Hamer, M" uniqKey="Hamer M">M Hamer</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Tonetti, Ms" uniqKey="Tonetti M">MS Tonetti</name>
</author>
<author><name sortKey="Van Dyke, Te" uniqKey="Van Dyke T">TE Van Dyke</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Schenkein, Ha" uniqKey="Schenkein H">HA Schenkein</name>
</author>
<author><name sortKey="Loos, Bg" uniqKey="Loos B">BG Loos</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Destefano, F" uniqKey="Destefano F">F DeStefano</name>
</author>
<author><name sortKey="Anda, Rf" uniqKey="Anda R">RF Anda</name>
</author>
<author><name sortKey="Kahn, Hs" uniqKey="Kahn H">HS Kahn</name>
</author>
<author><name sortKey="Williamson, Df" uniqKey="Williamson D">DF Williamson</name>
</author>
<author><name sortKey="Russell, Cm" uniqKey="Russell C">CM Russell</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Beck, J" uniqKey="Beck J">J Beck</name>
</author>
<author><name sortKey="Garcia, R" uniqKey="Garcia R">R Garcia</name>
</author>
<author><name sortKey="Heiss, G" uniqKey="Heiss G">G Heiss</name>
</author>
<author><name sortKey="Vokonas, Ps" uniqKey="Vokonas P">PS Vokonas</name>
</author>
<author><name sortKey="Offenbacher, S" uniqKey="Offenbacher S">S Offenbacher</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Morrison, Hi" uniqKey="Morrison H">HI Morrison</name>
</author>
<author><name sortKey="Ellison, Lf" uniqKey="Ellison L">LF Ellison</name>
</author>
<author><name sortKey="Taylor, Gw" uniqKey="Taylor G">GW Taylor</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Emingil, G" uniqKey="Emingil G">G Emingil</name>
</author>
<author><name sortKey="Buduneli, E" uniqKey="Buduneli E">E Buduneli</name>
</author>
<author><name sortKey="Aliyev, A" uniqKey="Aliyev A">A Aliyev</name>
</author>
<author><name sortKey="Akilli, A" uniqKey="Akilli A">A Akilli</name>
</author>
<author><name sortKey="Atilla, G" uniqKey="Atilla G">G Atilla</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Janket, Sj" uniqKey="Janket S">SJ Janket</name>
</author>
<author><name sortKey="Baird, Ae" uniqKey="Baird A">AE Baird</name>
</author>
<author><name sortKey="Chuang, Sk" uniqKey="Chuang S">SK Chuang</name>
</author>
<author><name sortKey="Jones, Ja" uniqKey="Jones J">JA Jones</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Dietrich, T" uniqKey="Dietrich T">T Dietrich</name>
</author>
<author><name sortKey="Jimenez, M" uniqKey="Jimenez M">M Jimenez</name>
</author>
<author><name sortKey="Krall Kaye, Ea" uniqKey="Krall Kaye E">EA Krall Kaye</name>
</author>
<author><name sortKey="Vokonas, Ps" uniqKey="Vokonas P">PS Vokonas</name>
</author>
<author><name sortKey="Garcia, Ri" uniqKey="Garcia R">RI Garcia</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Blaizot, A" uniqKey="Blaizot A">A Blaizot</name>
</author>
<author><name sortKey="Vergnes, Jn" uniqKey="Vergnes J">JN Vergnes</name>
</author>
<author><name sortKey="Nuwwareh, S" uniqKey="Nuwwareh S">S Nuwwareh</name>
</author>
<author><name sortKey="Amar, J" uniqKey="Amar J">J Amar</name>
</author>
<author><name sortKey="Sixou, M" uniqKey="Sixou M">M Sixou</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lockhart, Pb" uniqKey="Lockhart P">PB Lockhart</name>
</author>
<author><name sortKey="Bolger, Af" uniqKey="Bolger A">AF Bolger</name>
</author>
<author><name sortKey="Papapanou, Pn" uniqKey="Papapanou P">PN Papapanou</name>
</author>
<author><name sortKey="Osinbowale, O" uniqKey="Osinbowale O">O Osinbowale</name>
</author>
<author><name sortKey="Trevisan, M" uniqKey="Trevisan M">M Trevisan</name>
</author>
<author><name sortKey="Levison, Me" uniqKey="Levison M">ME Levison</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Dietrich, T" uniqKey="Dietrich T">T Dietrich</name>
</author>
<author><name sortKey="Sharma, P" uniqKey="Sharma P">P Sharma</name>
</author>
<author><name sortKey="Walter, C" uniqKey="Walter C">C Walter</name>
</author>
<author><name sortKey="Weston, P" uniqKey="Weston P">P Weston</name>
</author>
<author><name sortKey="Beck, J" uniqKey="Beck J">J Beck</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Wu, T" uniqKey="Wu T">T Wu</name>
</author>
<author><name sortKey="Trevisan, M" uniqKey="Trevisan M">M Trevisan</name>
</author>
<author><name sortKey="Genco, Rj" uniqKey="Genco R">RJ Genco</name>
</author>
<author><name sortKey="Dorn, Jp" uniqKey="Dorn J">JP Dorn</name>
</author>
<author><name sortKey="Falkner, Kl" uniqKey="Falkner K">KL Falkner</name>
</author>
<author><name sortKey="Sempos, Ct" uniqKey="Sempos C">CT Sempos</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Grau, Aj" uniqKey="Grau A">AJ Grau</name>
</author>
<author><name sortKey="Becher, H" uniqKey="Becher H">H Becher</name>
</author>
<author><name sortKey="Ziegler, Cm" uniqKey="Ziegler C">CM Ziegler</name>
</author>
<author><name sortKey="Lichy, C" uniqKey="Lichy C">C Lichy</name>
</author>
<author><name sortKey="Buggle, F" uniqKey="Buggle F">F Buggle</name>
</author>
<author><name sortKey="Kaiser, C" uniqKey="Kaiser C">C Kaiser</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Sim, Sj" uniqKey="Sim S">SJ Sim</name>
</author>
<author><name sortKey="Kim, Hd" uniqKey="Kim H">HD Kim</name>
</author>
<author><name sortKey="Moon, Jy" uniqKey="Moon J">JY Moon</name>
</author>
<author><name sortKey="Zavras, Ai" uniqKey="Zavras A">AI Zavras</name>
</author>
<author><name sortKey="Zdanowicz, J" uniqKey="Zdanowicz J">J Zdanowicz</name>
</author>
<author><name sortKey="Jang, Sj" uniqKey="Jang S">SJ Jang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Jimenez, M" uniqKey="Jimenez M">M Jimenez</name>
</author>
<author><name sortKey="Krall, Ea" uniqKey="Krall E">EA Krall</name>
</author>
<author><name sortKey="Garcia, Ri" uniqKey="Garcia R">RI Garcia</name>
</author>
<author><name sortKey="Vokonas, Ps" uniqKey="Vokonas P">PS Vokonas</name>
</author>
<author><name sortKey="Dietrich, T" uniqKey="Dietrich T">T Dietrich</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Grau, Aj" uniqKey="Grau A">AJ Grau</name>
</author>
<author><name sortKey="Urbanek, C" uniqKey="Urbanek C">C Urbanek</name>
</author>
<author><name sortKey="Palm, F" uniqKey="Palm F">F Palm</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lafon, A" uniqKey="Lafon A">A Lafon</name>
</author>
<author><name sortKey="Pereira, B" uniqKey="Pereira B">B Pereira</name>
</author>
<author><name sortKey="Dufour, T" uniqKey="Dufour T">T Dufour</name>
</author>
<author><name sortKey="Rigouby, V" uniqKey="Rigouby V">V Rigouby</name>
</author>
<author><name sortKey="Giroud, M" uniqKey="Giroud M">M Giroud</name>
</author>
<author><name sortKey="Bejot, Y" uniqKey="Bejot Y">Y Bejot</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hujoel, Pp" uniqKey="Hujoel P">PP Hujoel</name>
</author>
<author><name sortKey="Drangsholt, M" uniqKey="Drangsholt M">M Drangsholt</name>
</author>
<author><name sortKey="Spiekerman, C" uniqKey="Spiekerman C">C Spiekerman</name>
</author>
<author><name sortKey="Derouen, Ta" uniqKey="Derouen T">TA DeRouen</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Howell, Th" uniqKey="Howell T">TH Howell</name>
</author>
<author><name sortKey="Ridker, Pm" uniqKey="Ridker P">PM Ridker</name>
</author>
<author><name sortKey="Ajani, Ua" uniqKey="Ajani U">UA Ajani</name>
</author>
<author><name sortKey="Hennekens, Ch" uniqKey="Hennekens C">CH Hennekens</name>
</author>
<author><name sortKey="Christen, Wg" uniqKey="Christen W">WG Christen</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Tuominen, R" uniqKey="Tuominen R">R Tuominen</name>
</author>
<author><name sortKey="Reunanen, A" uniqKey="Reunanen A">A Reunanen</name>
</author>
<author><name sortKey="Paunio, M" uniqKey="Paunio M">M Paunio</name>
</author>
<author><name sortKey="Paunio, I" uniqKey="Paunio I">I Paunio</name>
</author>
<author><name sortKey="Aromaa, A" uniqKey="Aromaa A">A Aromaa</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Thomopoulos, C" uniqKey="Thomopoulos C">C Thomopoulos</name>
</author>
<author><name sortKey="Tsioufis, C" uniqKey="Tsioufis C">C Tsioufis</name>
</author>
<author><name sortKey="Soldatos, N" uniqKey="Soldatos N">N Soldatos</name>
</author>
<author><name sortKey="Kasiakogias, A" uniqKey="Kasiakogias A">A Kasiakogias</name>
</author>
<author><name sortKey="Stefanadis, C" uniqKey="Stefanadis C">C Stefanadis</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Rachel Lu, Jf" uniqKey="Rachel Lu J">JF Rachel Lu</name>
</author>
<author><name sortKey="Chiang, Tl" uniqKey="Chiang T">TL Chiang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Tang, Ch" uniqKey="Tang C">CH Tang</name>
</author>
<author><name sortKey="Wu, Cs" uniqKey="Wu C">CS Wu</name>
</author>
<author><name sortKey="Lee, Th" uniqKey="Lee T">TH Lee</name>
</author>
<author><name sortKey="Hung, St" uniqKey="Hung S">ST Hung</name>
</author>
<author><name sortKey="Yang, Cy" uniqKey="Yang C">CY Yang</name>
</author>
<author><name sortKey="Lee, Ch" uniqKey="Lee C">CH Lee</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lin, Ys" uniqKey="Lin Y">YS Lin</name>
</author>
<author><name sortKey="Tang, Ch" uniqKey="Tang C">CH Tang</name>
</author>
<author><name sortKey="Yang, Cy" uniqKey="Yang C">CY Yang</name>
</author>
<author><name sortKey="Wu, Ls" uniqKey="Wu L">LS Wu</name>
</author>
<author><name sortKey="Hung, St" uniqKey="Hung S">ST Hung</name>
</author>
<author><name sortKey="Hwa, Hl" uniqKey="Hwa H">HL Hwa</name>
</author>
</analytic>
</biblStruct>
<biblStruct></biblStruct>
<biblStruct><analytic><author><name sortKey="Jason, Pf" uniqKey="Jason P">PF Jason</name>
</author>
<author><name sortKey="Robert, Jg" uniqKey="Robert J">JG Robert</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Tonetti, Ms" uniqKey="Tonetti M">MS Tonetti</name>
</author>
<author><name sortKey="D Aiuto, F" uniqKey="D Aiuto F">F D'Aiuto</name>
</author>
<author><name sortKey="Nibali, L" uniqKey="Nibali L">L Nibali</name>
</author>
<author><name sortKey="Donald, A" uniqKey="Donald A">A Donald</name>
</author>
<author><name sortKey="Storry, C" uniqKey="Storry C">C Storry</name>
</author>
<author><name sortKey="Parkar, M" uniqKey="Parkar M">M Parkar</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Paraskevas, S" uniqKey="Paraskevas S">S Paraskevas</name>
</author>
<author><name sortKey="Huizinga, Jd" uniqKey="Huizinga J">JD Huizinga</name>
</author>
<author><name sortKey="Loos, Bg" uniqKey="Loos B">BG Loos</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Piconi, S" uniqKey="Piconi S">S Piconi</name>
</author>
<author><name sortKey="Trabattoni, D" uniqKey="Trabattoni D">D Trabattoni</name>
</author>
<author><name sortKey="Luraghi, C" uniqKey="Luraghi C">C Luraghi</name>
</author>
<author><name sortKey="Perilli, E" uniqKey="Perilli E">E Perilli</name>
</author>
<author><name sortKey="Borelli, M" uniqKey="Borelli M">M Borelli</name>
</author>
<author><name sortKey="Pacei, M" uniqKey="Pacei M">M Pacei</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Loos, Bg" uniqKey="Loos B">BG Loos</name>
</author>
<author><name sortKey="Craandijk, J" uniqKey="Craandijk J">J Craandijk</name>
</author>
<author><name sortKey="Hoek, Fj" uniqKey="Hoek F">FJ Hoek</name>
</author>
<author><name sortKey="Wertheim Van Dillen, Pm" uniqKey="Wertheim Van Dillen P">PM Wertheim-van Dillen</name>
</author>
<author><name sortKey="Van Der Velden, U" uniqKey="Van Der Velden U">U van der Velden</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Noack, B" uniqKey="Noack B">B Noack</name>
</author>
<author><name sortKey="Genco, Rj" uniqKey="Genco R">RJ Genco</name>
</author>
<author><name sortKey="Trevisan, M" uniqKey="Trevisan M">M Trevisan</name>
</author>
<author><name sortKey="Grossi, S" uniqKey="Grossi S">S Grossi</name>
</author>
<author><name sortKey="Zambon, Jj" uniqKey="Zambon J">JJ Zambon</name>
</author>
<author><name sortKey="De Nardin, E" uniqKey="De Nardin E">E De Nardin</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Loos, Bg" uniqKey="Loos B">BG Loos</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Slade, Gd" uniqKey="Slade G">GD Slade</name>
</author>
<author><name sortKey="Offenbacher, S" uniqKey="Offenbacher S">S Offenbacher</name>
</author>
<author><name sortKey="Beck, Jd" uniqKey="Beck J">JD Beck</name>
</author>
<author><name sortKey="Heiss, G" uniqKey="Heiss G">G Heiss</name>
</author>
<author><name sortKey="Pankow, Js" uniqKey="Pankow J">JS Pankow</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Wu, T" uniqKey="Wu T">T Wu</name>
</author>
<author><name sortKey="Trevisan, M" uniqKey="Trevisan M">M Trevisan</name>
</author>
<author><name sortKey="Genco, Rj" uniqKey="Genco R">RJ Genco</name>
</author>
<author><name sortKey="Falkner, Kl" uniqKey="Falkner K">KL Falkner</name>
</author>
<author><name sortKey="Dorn, Jp" uniqKey="Dorn J">JP Dorn</name>
</author>
<author><name sortKey="Sempos, Ct" uniqKey="Sempos C">CT Sempos</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Bokhari, Sa" uniqKey="Bokhari S">SA Bokhari</name>
</author>
<author><name sortKey="Khan, Aa" uniqKey="Khan A">AA Khan</name>
</author>
<author><name sortKey="Butt, Ak" uniqKey="Butt A">AK Butt</name>
</author>
<author><name sortKey="Hanif, M" uniqKey="Hanif M">M Hanif</name>
</author>
<author><name sortKey="Izhar, M" uniqKey="Izhar M">M Izhar</name>
</author>
<author><name sortKey="Tatakis, Dn" uniqKey="Tatakis D">DN Tatakis</name>
</author>
</analytic>
</biblStruct>
<biblStruct></biblStruct>
<biblStruct><analytic><author><name sortKey="Chun, Yh" uniqKey="Chun Y">YH Chun</name>
</author>
<author><name sortKey="Chun, Kr" uniqKey="Chun K">KR Chun</name>
</author>
<author><name sortKey="Olguin, D" uniqKey="Olguin D">D Olguin</name>
</author>
<author><name sortKey="Wang, Hl" uniqKey="Wang H">HL Wang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Tabeta, K" uniqKey="Tabeta K">K Tabeta</name>
</author>
<author><name sortKey="Yamazaki, K" uniqKey="Yamazaki K">K Yamazaki</name>
</author>
<author><name sortKey="Hotokezaka, H" uniqKey="Hotokezaka H">H Hotokezaka</name>
</author>
<author><name sortKey="Yoshie, H" uniqKey="Yoshie H">H Yoshie</name>
</author>
<author><name sortKey="Hara, K" uniqKey="Hara K">K Hara</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Seymour, Gj" uniqKey="Seymour G">GJ Seymour</name>
</author>
<author><name sortKey="Ford, Pj" uniqKey="Ford P">PJ Ford</name>
</author>
<author><name sortKey="Cullinan, Mp" uniqKey="Cullinan M">MP Cullinan</name>
</author>
<author><name sortKey="Leishman, S" uniqKey="Leishman S">S Leishman</name>
</author>
<author><name sortKey="Yamazaki, K" uniqKey="Yamazaki K">K Yamazaki</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ford, Pj" uniqKey="Ford P">PJ Ford</name>
</author>
<author><name sortKey="Gemmell, E" uniqKey="Gemmell E">E Gemmell</name>
</author>
<author><name sortKey="Timms, P" uniqKey="Timms P">P Timms</name>
</author>
<author><name sortKey="Chan, A" uniqKey="Chan A">A Chan</name>
</author>
<author><name sortKey="Preston, Fm" uniqKey="Preston F">FM Preston</name>
</author>
<author><name sortKey="Seymour, Gj" uniqKey="Seymour G">GJ Seymour</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Haraszthy, Vi" uniqKey="Haraszthy V">VI Haraszthy</name>
</author>
<author><name sortKey="Zambon, Jj" uniqKey="Zambon J">JJ Zambon</name>
</author>
<author><name sortKey="Trevisan, M" uniqKey="Trevisan M">M Trevisan</name>
</author>
<author><name sortKey="Zeid, M" uniqKey="Zeid M">M Zeid</name>
</author>
<author><name sortKey="Genco, Rj" uniqKey="Genco R">RJ Genco</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Fiehn, Ne" uniqKey="Fiehn N">NE Fiehn</name>
</author>
<author><name sortKey="Larsen, T" uniqKey="Larsen T">T Larsen</name>
</author>
<author><name sortKey="Christiansen, N" uniqKey="Christiansen N">N Christiansen</name>
</author>
<author><name sortKey="Holmstrup, P" uniqKey="Holmstrup P">P Holmstrup</name>
</author>
<author><name sortKey="Schroeder, Tv" uniqKey="Schroeder T">TV Schroeder</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Calandrini, Ca" uniqKey="Calandrini C">CA Calandrini</name>
</author>
<author><name sortKey="Ribeiro, Ac" uniqKey="Ribeiro A">AC Ribeiro</name>
</author>
<author><name sortKey="Gonnelli, Ac" uniqKey="Gonnelli A">AC Gonnelli</name>
</author>
<author><name sortKey="Ota Tsuzuki, C" uniqKey="Ota Tsuzuki C">C Ota-Tsuzuki</name>
</author>
<author><name sortKey="Rangel, Lp" uniqKey="Rangel L">LP Rangel</name>
</author>
<author><name sortKey="Saba Chujfi, E" uniqKey="Saba Chujfi E">E Saba-Chujfi</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kozarov, Ev" uniqKey="Kozarov E">EV Kozarov</name>
</author>
<author><name sortKey="Dorn, Br" uniqKey="Dorn B">BR Dorn</name>
</author>
<author><name sortKey="Shelburne, Ce" uniqKey="Shelburne C">CE Shelburne</name>
</author>
<author><name sortKey="Dunn, Wa" uniqKey="Dunn W">WA Dunn</name>
</author>
<author><name sortKey="Progulske Fox, A" uniqKey="Progulske Fox A">A Progulske-Fox</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Aimetti, M" uniqKey="Aimetti M">M Aimetti</name>
</author>
<author><name sortKey="Romano, F" uniqKey="Romano F">F Romano</name>
</author>
<author><name sortKey="Nessi, F" uniqKey="Nessi F">F Nessi</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Cairo, F" uniqKey="Cairo F">F Cairo</name>
</author>
<author><name sortKey="Gaeta, C" uniqKey="Gaeta C">C Gaeta</name>
</author>
<author><name sortKey="Dorigo, W" uniqKey="Dorigo W">W Dorigo</name>
</author>
<author><name sortKey="Oggioni, Mr" uniqKey="Oggioni M">MR Oggioni</name>
</author>
<author><name sortKey="Pratesi, C" uniqKey="Pratesi C">C Pratesi</name>
</author>
<author><name sortKey="Pini Prato, Gp" uniqKey="Pini Prato G">GP Pini Prato</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Losche, W" uniqKey="Losche W">W Losche</name>
</author>
<author><name sortKey="Karapetow, F" uniqKey="Karapetow F">F Karapetow</name>
</author>
<author><name sortKey="Pohl, A" uniqKey="Pohl A">A Pohl</name>
</author>
<author><name sortKey="Pohl, C" uniqKey="Pohl C">C Pohl</name>
</author>
<author><name sortKey="Kocher, T" uniqKey="Kocher T">T Kocher</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Katz, J" uniqKey="Katz J">J Katz</name>
</author>
<author><name sortKey="Chaushu, G" uniqKey="Chaushu G">G Chaushu</name>
</author>
<author><name sortKey="Sharabi, Y" uniqKey="Sharabi Y">Y Sharabi</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Nibali, L" uniqKey="Nibali L">L Nibali</name>
</author>
<author><name sortKey="D Aiuto, F" uniqKey="D Aiuto F">F D'Aiuto</name>
</author>
<author><name sortKey="Griffiths, G" uniqKey="Griffiths G">G Griffiths</name>
</author>
<author><name sortKey="Patel, K" uniqKey="Patel K">K Patel</name>
</author>
<author><name sortKey="Suvan, J" uniqKey="Suvan J">J Suvan</name>
</author>
<author><name sortKey="Tonetti, Ms" uniqKey="Tonetti M">MS Tonetti</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Oz, Sg" uniqKey="Oz S">SG Oz</name>
</author>
<author><name sortKey="Fentoglu, O" uniqKey="Fentoglu O">O Fentoglu</name>
</author>
<author><name sortKey="Kilicarslan, A" uniqKey="Kilicarslan A">A Kilicarslan</name>
</author>
<author><name sortKey="Guven, Gs" uniqKey="Guven G">GS Guven</name>
</author>
<author><name sortKey="Tanrtover, Md" uniqKey="Tanrtover M">MD Tanrtover</name>
</author>
<author><name sortKey="Aykac, Y" uniqKey="Aykac Y">Y Aykac</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Montebugnoli, L" uniqKey="Montebugnoli L">L Montebugnoli</name>
</author>
<author><name sortKey="Servidio, D" uniqKey="Servidio D">D Servidio</name>
</author>
<author><name sortKey="Miaton, Ra" uniqKey="Miaton R">RA Miaton</name>
</author>
<author><name sortKey="Prati, C" uniqKey="Prati C">C Prati</name>
</author>
<author><name sortKey="Tricoci, P" uniqKey="Tricoci P">P Tricoci</name>
</author>
<author><name sortKey="Melloni, C" uniqKey="Melloni C">C Melloni</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Losche, W" uniqKey="Losche W">W Losche</name>
</author>
<author><name sortKey="Marshal, Gj" uniqKey="Marshal G">GJ Marshal</name>
</author>
<author><name sortKey="Apatzidou, Da" uniqKey="Apatzidou D">DA Apatzidou</name>
</author>
<author><name sortKey="Krause, S" uniqKey="Krause S">S Krause</name>
</author>
<author><name sortKey="Kocher, T" uniqKey="Kocher T">T Kocher</name>
</author>
<author><name sortKey="Kinane, Df" uniqKey="Kinane D">DF Kinane</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kornman, Ks" uniqKey="Kornman K">KS Kornman</name>
</author>
<author><name sortKey="Duff, Gw" uniqKey="Duff G">GW Duff</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Diez Roux, Av" uniqKey="Diez Roux A">AV Diez Roux</name>
</author>
<author><name sortKey="Merkin, Ss" uniqKey="Merkin S">SS Merkin</name>
</author>
<author><name sortKey="Arnett, D" uniqKey="Arnett D">D Arnett</name>
</author>
<author><name sortKey="Chambless, L" uniqKey="Chambless L">L Chambless</name>
</author>
<author><name sortKey="Massing, M" uniqKey="Massing M">M Massing</name>
</author>
<author><name sortKey="Nieto, Fj" uniqKey="Nieto F">FJ Nieto</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Pussinen, Pj" uniqKey="Pussinen P">PJ Pussinen</name>
</author>
<author><name sortKey="Alfthan, G" uniqKey="Alfthan G">G Alfthan</name>
</author>
<author><name sortKey="Jousilahti, P" uniqKey="Jousilahti P">P Jousilahti</name>
</author>
<author><name sortKey="Paju, S" uniqKey="Paju S">S Paju</name>
</author>
<author><name sortKey="Tuomilehto, J" uniqKey="Tuomilehto J">J Tuomilehto</name>
</author>
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<biblStruct><analytic><author><name sortKey="Dorn, Jm" uniqKey="Dorn J">JM Dorn</name>
</author>
<author><name sortKey="Genco, Rj" uniqKey="Genco R">RJ Genco</name>
</author>
<author><name sortKey="Grossi, Sg" uniqKey="Grossi S">SG Grossi</name>
</author>
<author><name sortKey="Falkner, Kl" uniqKey="Falkner K">KL Falkner</name>
</author>
<author><name sortKey="Hovey, Km" uniqKey="Hovey K">KM Hovey</name>
</author>
<author><name sortKey="Iacoviello, L" uniqKey="Iacoviello L">L Iacoviello</name>
</author>
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<pmc article-type="research-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">PLoS One</journal-id>
<journal-id journal-id-type="iso-abbrev">PLoS ONE</journal-id>
<journal-id journal-id-type="publisher-id">plos</journal-id>
<journal-id journal-id-type="pmc">plosone</journal-id>
<journal-title-group><journal-title>PLoS ONE</journal-title>
</journal-title-group>
<issn pub-type="epub">1932-6203</issn>
<publisher><publisher-name>Public Library of Science</publisher-name>
<publisher-loc>San Francisco, CA USA</publisher-loc>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">26114433</article-id>
<article-id pub-id-type="pmc">4482590</article-id>
<article-id pub-id-type="doi">10.1371/journal.pone.0130807</article-id>
<article-id pub-id-type="publisher-id">PONE-D-15-02830</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject>
</subj-group>
</article-categories>
<title-group><article-title>Major Adverse Cardiovascular Events in Treated Periodontitis: A Population-Based Follow-Up Study from Taiwan</article-title>
<alt-title alt-title-type="running-head">Major Adverse Cardiovascular Events in Elderly Treated Periodontitis</alt-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Chou</surname>
<given-names>Shing-Hsien</given-names>
</name>
<xref ref-type="aff" rid="aff001"><sup>1</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Tung</surname>
<given-names>Ying-Chang</given-names>
</name>
<xref ref-type="aff" rid="aff001"><sup>1</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Lin</surname>
<given-names>Yu-Sheng</given-names>
</name>
<xref ref-type="aff" rid="aff001"><sup>1</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Wu</surname>
<given-names>Lung-Sheng</given-names>
</name>
<xref ref-type="aff" rid="aff001"><sup>1</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Lin</surname>
<given-names>Chia-Pin</given-names>
</name>
<xref ref-type="aff" rid="aff001"><sup>1</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Liou</surname>
<given-names>Eric Jein-Wein</given-names>
</name>
<xref ref-type="aff" rid="aff003"><sup>3</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Chang</surname>
<given-names>Chee-Jen</given-names>
</name>
<xref ref-type="aff" rid="aff002"><sup>2</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Kung</surname>
<given-names>Suefang</given-names>
</name>
<xref ref-type="aff" rid="aff004"><sup>4</sup>
</xref>
<xref ref-type="aff" rid="aff005"><sup>5</sup>
</xref>
<xref rid="cor001" ref-type="corresp">*</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Chu</surname>
<given-names>Pao-Hsien</given-names>
</name>
<xref ref-type="aff" rid="aff001"><sup>1</sup>
</xref>
<xref ref-type="aff" rid="aff006"><sup>6</sup>
</xref>
<xref ref-type="aff" rid="aff007"><sup>7</sup>
</xref>
<xref rid="cor001" ref-type="corresp">*</xref>
</contrib>
</contrib-group>
<aff id="aff001"><label>1</label>
<addr-line>Division of Cardiology, Department of Internal Medicine, Chang Gung Memorial Hospital, Taipei, Taiwan</addr-line>
</aff>
<aff id="aff002"><label>2</label>
<addr-line>Clinical Informatics and Medical Statistics Research Center, Chang Gung Memorial Hospital, Taipei, Taiwan</addr-line>
</aff>
<aff id="aff003"><label>3</label>
<addr-line>Department of Orthodontics and Craniofacial Dentistry, Chang Gung Memorial Hospital, Taipei, Taiwan</addr-line>
</aff>
<aff id="aff004"><label>4</label>
<addr-line>Division of Periodontology, Chang Gung Memorial Hospital, Taipei, Taiwan</addr-line>
</aff>
<aff id="aff005"><label>5</label>
<addr-line>Cheers Dental Clinic, New Taipei, Taiwan</addr-line>
</aff>
<aff id="aff006"><label>6</label>
<addr-line>Healthcare Center, Chang Gung Memorial Hospital, Taipei, Taiwan</addr-line>
</aff>
<aff id="aff007"><label>7</label>
<addr-line>Heart Failure Center, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Taipei, Taiwan</addr-line>
</aff>
<contrib-group><contrib contrib-type="editor"><name><surname>Kokubo</surname>
<given-names>Yoshihiro</given-names>
</name>
<role>Editor</role>
<xref ref-type="aff" rid="edit1"></xref>
</contrib>
</contrib-group>
<aff id="edit1"><addr-line>National Cardiovascular Center Hospital, JAPAN</addr-line>
</aff>
<author-notes><fn fn-type="conflict" id="coi001"><p><bold>Competing Interests: </bold>
The authors have declared that no competing interests exist.</p>
</fn>
<fn fn-type="con" id="contrib001"><p>Conceived and designed the experiments: SK PHC. Performed the experiments: SHC YCT YSL LSW CPL. Analyzed the data: EJWL CJC PHC. Contributed reagents/materials/analysis tools: SK PHC. Wrote the paper: SHC YCT.</p>
</fn>
<corresp id="cor001">* E-mail: <email>pskung@gmail.com</email>
(SK); <email>pchu@adm.cgmh.org.tw</email>
(PHC)</corresp>
</author-notes>
<pub-date pub-type="epub"><day>26</day>
<month>6</month>
<year>2015</year>
</pub-date>
<pub-date pub-type="collection"><year>2015</year>
</pub-date>
<volume>10</volume>
<issue>6</issue>
<elocation-id>e0130807</elocation-id>
<history><date date-type="received"><day>31</day>
<month>1</month>
<year>2015</year>
</date>
<date date-type="accepted"><day>26</day>
<month>5</month>
<year>2015</year>
</date>
</history>
<permissions><copyright-year>2015</copyright-year>
<copyright-holder>Chou et al</copyright-holder>
<license xlink:href="http://creativecommons.org/licenses/by/4.0/"><license-p>This is an open access article distributed under the terms of the <ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by/4.0/">Creative Commons Attribution License</ext-link>
, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited</license-p>
</license>
</permissions>
<self-uri content-type="pdf" xlink:type="simple" xlink:href="pone.0130807.pdf"></self-uri>
<abstract><sec id="sec001"><title>Background</title>
<p>The aim of the present study was to identify the long-term major adverse cardiovascular events (MACE) in treated periodontitis patients in Taiwan.</p>
</sec>
<sec id="sec002"><title>Methods</title>
<p>From the National Health Insurance Research Database (2001-2010), adult patients (≥ 18 years) with treated periodontitis were identified. Comparison was made between patients with mild form and severe form of treated periodontitis after propensity score matching. The primary end point was the incidence of MACE.</p>
</sec>
<sec id="sec003"><title>Results</title>
<p>A total of 32,504 adult patients with treated periodontitis were identified between 2001 and 2010. After propensity score matching, 27,146 patients were preserved for comparison, including 13,573 patients with mild form and 13,573 patients with severe form of treated periodontitis. During follow-up, 728 individuals in mild treated periodontitis group and 1,206 individuals in severe treated periodontitis group had at least 1 MACE event. After adjustment for gender, hyperlipidemia, hypertension and diabetes mellitus, severe treated periodontitis was associated with a mildly but significantly increased risk of MACE among older patients > 60 years of age (incidence rate ratio, 1.26; 95% confidence interval, 1.08–1.46). No association was found among younger patients ≤ 60 years of age.</p>
</sec>
<sec id="sec004"><title>Conclusions</title>
<p>Severe form of treated periodontitis was associated with an increased risk of MACE among older Taiwanese patients, but not among younger Taiwanese patients. We should put more efforts on the improvement of periodontal health to prevent further MACE.</p>
</sec>
</abstract>
<funding-group><funding-statement>This work was supported by grants from the Chang Gung Memorial Hospital, Taiwan (CLRPG340599). Dr. Chu was supported by a grant from the Chang Gung Memorial Hospital (CMRPG32057) and grants from the National Sciences Council, Taiwan (NSC 96-2314-B-182-026, 97-2314-B-182-028-MY2, and 99-2314-B-182A-106-MY3). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.</funding-statement>
</funding-group>
<counts><fig-count count="2"></fig-count>
<table-count count="3"></table-count>
<page-count count="13"></page-count>
</counts>
<custom-meta-group><custom-meta id="data-availability"><meta-name>Data Availability</meta-name>
<meta-value>All relevant data are within the paper.</meta-value>
</custom-meta>
</custom-meta-group>
</article-meta>
<notes><title>Data Availability</title>
<p>All relevant data are within the paper.</p>
</notes>
</front>
</pmc>
</record>
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