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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Frequency of Dental Implants Placed in the Esthetic Zone in Dental Clinic of Tehran University: A Descriptive Study</title><author><name sortKey="Rasouli Ghahroudi, Amir Alireza" sort="Rasouli Ghahroudi, Amir Alireza" uniqKey="Rasouli Ghahroudi A" first="Amir Alireza" last="Rasouli Ghahroudi">Amir Alireza Rasouli Ghahroudi</name><affiliation><nlm:aff id="AFF1">Associate Professor, Dental Implant Research Center, Dentistry Research Institute, Tehran University of Medical Sciences, Tehran, Iran; Department of Periodontics, School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran</nlm:aff></affiliation></author><author><name sortKey="Homayouni, Ali" sort="Homayouni, Ali" uniqKey="Homayouni A" first="Ali" last="Homayouni">Ali Homayouni</name><affiliation><nlm:aff id="AFF2">Dental Student, Tehran University of Medical Sciences, Tehran, Iran</nlm:aff></affiliation></author><author><name sortKey="Rokn, Amir Reza" sort="Rokn, Amir Reza" uniqKey="Rokn A" first="Amir Reza" last="Rokn">Amir Reza Rokn</name><affiliation><nlm:aff id="AFF3">Professor, Dental Implant Research Center, Dentistry Research Institute, Tehran University of Medical Sciences, Tehran, Iran; Department of Periodontics, School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran</nlm:aff></affiliation></author><author><name sortKey="Kia, Fatemeh" sort="Kia, Fatemeh" uniqKey="Kia F" first="Fatemeh" last="Kia">Fatemeh Kia</name><affiliation><nlm:aff id="AFF4">Dental Student, International Branch of Tehran University of Medical Sciences, Tehran, Iran</nlm:aff></affiliation></author><author><name sortKey="Kharazifard, Mohammad Javad" sort="Kharazifard, Mohammad Javad" uniqKey="Kharazifard M" first="Mohammad Javad" last="Kharazifard">Mohammad Javad Kharazifard</name><affiliation><nlm:aff id="AFF5">Epidemiologist, Dental Research Center, Dentistry Research Institute, Tehran, Iran; Statistical and Methodology Department, School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran</nlm:aff></affiliation></author><author><name sortKey="Khorsand, Afshin" sort="Khorsand, Afshin" uniqKey="Khorsand A" first="Afshin" last="Khorsand">Afshin Khorsand</name><affiliation><nlm:aff id="AFF6">Associate Professor, Dental Research Center, Dentistry Research Institute, Tehran University of Medical Sciences, Tehran, Iran; Department of Periodontics, School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">27559350</idno><idno type="pmc">4983306</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4983306</idno><idno type="RBID">PMC:4983306</idno><date when="2015">2015</date><idno type="wicri:Area/Pmc/Corpus">003065</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">003065</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Frequency of Dental Implants Placed in the Esthetic Zone in Dental Clinic of Tehran University: A Descriptive Study</title><author><name sortKey="Rasouli Ghahroudi, Amir Alireza" sort="Rasouli Ghahroudi, Amir Alireza" uniqKey="Rasouli Ghahroudi A" first="Amir Alireza" last="Rasouli Ghahroudi">Amir Alireza Rasouli Ghahroudi</name><affiliation><nlm:aff id="AFF1">Associate Professor, Dental Implant Research Center, Dentistry Research Institute, Tehran University of Medical Sciences, Tehran, Iran; Department of Periodontics, School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran</nlm:aff></affiliation></author><author><name sortKey="Homayouni, Ali" sort="Homayouni, Ali" uniqKey="Homayouni A" first="Ali" last="Homayouni">Ali Homayouni</name><affiliation><nlm:aff id="AFF2">Dental Student, Tehran University of Medical Sciences, Tehran, Iran</nlm:aff></affiliation></author><author><name sortKey="Rokn, Amir Reza" sort="Rokn, Amir Reza" uniqKey="Rokn A" first="Amir Reza" last="Rokn">Amir Reza Rokn</name><affiliation><nlm:aff id="AFF3">Professor, Dental Implant Research Center, Dentistry Research Institute, Tehran University of Medical Sciences, Tehran, Iran; Department of Periodontics, School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran</nlm:aff></affiliation></author><author><name sortKey="Kia, Fatemeh" sort="Kia, Fatemeh" uniqKey="Kia F" first="Fatemeh" last="Kia">Fatemeh Kia</name><affiliation><nlm:aff id="AFF4">Dental Student, International Branch of Tehran University of Medical Sciences, Tehran, Iran</nlm:aff></affiliation></author><author><name sortKey="Kharazifard, Mohammad Javad" sort="Kharazifard, Mohammad Javad" uniqKey="Kharazifard M" first="Mohammad Javad" last="Kharazifard">Mohammad Javad Kharazifard</name><affiliation><nlm:aff id="AFF5">Epidemiologist, Dental Research Center, Dentistry Research Institute, Tehran, Iran; Statistical and Methodology Department, School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran</nlm:aff></affiliation></author><author><name sortKey="Khorsand, Afshin" sort="Khorsand, Afshin" uniqKey="Khorsand A" first="Afshin" last="Khorsand">Afshin Khorsand</name><affiliation><nlm:aff id="AFF6">Associate Professor, Dental Research Center, Dentistry Research Institute, Tehran University of Medical Sciences, Tehran, Iran; Department of Periodontics, School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran</nlm:aff></affiliation></author></analytic><series><title level="j">Journal of Dentistry (Tehran, Iran)</title><idno type="ISSN">1735-2150</idno><idno type="eISSN">2008-2185</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Objectives:</title><p>Anterior maxilla, known as the esthetic zone, plays an important role in facial and smile esthetics. This study assessed the frequency of implant treatments in the esthetic zone of patients presenting to Dental Implant Department of Tehran University during 2002–2012.</p></sec><sec><title>Materials and Methods:</title><p>This descriptive study was conducted on dental records of patients receiving implant treatment during 2002–2012. Patient records were retrieved from the archives and patient demographics, implant characteristics, failure rate, prevalence of complications and implant systems were collected. The data were reported as frequency and percentage.</p></sec><sec><title>Results:</title><p>Of a total of 2,381 implants placed in the mentioned time period, 492 (20.8%) had been placed in the anterior maxilla and 531 (22.3%) had been placed in the anterior mandible from canine to canine. Timing of implant placement was immediate in 12.0%, early in 0.5% and late in 87.4%. Survival rate was 99.1%. Rate of failure was 0.8%. Failure rate was 0.4% in the maxillary and 1.1% in the mandibular canine to canine region. Complications were reported in 10.1% of patients. Rate of complications was 18.3% in the maxillary canine to canine, 8.9% in the mandibular canine to canine, 18.1% in the maxillary first premolar to first premolar and 9.5% in the mandibular first premolar to first premolar. The frequency of bone grafts placed in these areas was 17.6%, 33.9%, 13.6%, 32.1% and 14.3%, respectively.</p></sec><sec><title>Conclusion:</title><p>Of implants placed in our center, around 20% were in the anterior maxilla, and delayed implant placement was the most commonly adopted technique.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Rokn, A" uniqKey="Rokn A">A Rokn</name></author><author><name sortKey="Rasouli Ghahroudi, Aa" uniqKey="Rasouli Ghahroudi A">AA Rasouli-Ghahroudi</name></author><author><name sortKey="Daneshmonfared, M" uniqKey="Daneshmonfared M">M Daneshmonfared</name></author><author><name sortKey="Menasheof, R" uniqKey="Menasheof R">R Menasheof</name></author><author><name sortKey="Shamshiri, Ar" uniqKey="Shamshiri A">AR. 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<front><journal-meta><journal-id journal-id-type="nlm-ta">J Dent (Tehran)</journal-id><journal-id journal-id-type="iso-abbrev">J Dent (Tehran)</journal-id><journal-id journal-id-type="publisher-id">JOD</journal-id><journal-id journal-id-type="pmc">JOD</journal-id><journal-title-group><journal-title>Journal of Dentistry (Tehran, Iran)</journal-title></journal-title-group><issn pub-type="ppub">1735-2150</issn><issn pub-type="epub">2008-2185</issn><publisher><publisher-name>Tehran University of Medical Sciences</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">27559350</article-id><article-id pub-id-type="pmc">4983306</article-id><article-id pub-id-type="publisher-id">jod-12-906</article-id><article-categories><subj-group subj-group-type="heading"><subject>Original Article</subject></subj-group></article-categories><title-group><article-title>Frequency of Dental Implants Placed in the Esthetic Zone in Dental Clinic of Tehran University: A Descriptive Study</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Rasouli Ghahroudi</surname><given-names>Amir Alireza</given-names></name><xref ref-type="aff" rid="AFF1"><sup>1</sup></xref></contrib><contrib contrib-type="author"><name><surname>Homayouni</surname><given-names>Ali</given-names></name><xref ref-type="aff" rid="AFF2"><sup>2</sup></xref></contrib><contrib contrib-type="author"><name><surname>Rokn</surname><given-names>Amir Reza</given-names></name><xref ref-type="aff" rid="AFF3"><sup>3</sup></xref></contrib><contrib contrib-type="author"><name><surname>Kia</surname><given-names>Fatemeh</given-names></name><xref ref-type="aff" rid="AFF4"><sup>4</sup></xref></contrib><contrib contrib-type="author"><name><surname>Kharazifard</surname><given-names>Mohammad Javad</given-names></name><xref ref-type="aff" rid="AFF5"><sup>5</sup></xref></contrib><contrib contrib-type="author"><name><surname>Khorsand</surname><given-names>Afshin</given-names></name><xref ref-type="aff" rid="AFF6"><sup>6</sup></xref><xref ref-type="corresp" rid="C1"><sup>*</sup></xref></contrib><aff id="AFF1"><label>1</label>Associate Professor, Dental Implant Research Center, Dentistry Research Institute, Tehran University of Medical Sciences, Tehran, Iran; Department of Periodontics, School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran</aff><aff id="AFF2"><label>2</label>Dental Student, Tehran University of Medical Sciences, Tehran, Iran</aff><aff id="AFF3"><label>3</label>Professor, Dental Implant Research Center, Dentistry Research Institute, Tehran University of Medical Sciences, Tehran, Iran; Department of Periodontics, School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran</aff><aff id="AFF4"><label>4</label>Dental Student, International Branch of Tehran University of Medical Sciences, Tehran, Iran</aff><aff id="AFF5"><label>5</label>Epidemiologist, Dental Research Center, Dentistry Research Institute, Tehran, Iran; Statistical and Methodology Department, School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran</aff><aff id="AFF6"><label>6</label>Associate Professor, Dental Research Center, Dentistry Research Institute, Tehran University of Medical Sciences, Tehran, Iran; Department of Periodontics, School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran</aff></contrib-group><author-notes><corresp id="C1"><label>*</label>Corresponding author: A. Khorsand, Dental Research Center, Dentistry Research Institute, Tehran University of Medical Sciences, Tehran, Iran; Department of Periodontics, School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran, <email>a_afshin_khorsand@yahoo.com</email></corresp></author-notes><pub-date pub-type="ppub"><month>12</month><year>2015</year></pub-date><volume>12</volume><issue>12</issue><fpage>906</fpage><lpage>912</lpage><history><date date-type="received"><day>3</day><month>7</month><year>2015</year></date><date date-type="accepted"><day>27</day><month>10</month><year>2015</year></date></history><permissions><copyright-statement>Copyright© Dental Research Center, Tehran University of Medical Sciences</copyright-statement><copyright-year>2015</copyright-year><license><license-p>This work is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License which allows users to read, copy, distribute and make derivative works for non-commercial purposes from the material, as long as the author of the original work is cited properly.</license-p></license></permissions><abstract><sec><title>Objectives:</title><p>Anterior maxilla, known as the esthetic zone, plays an important role in facial and smile esthetics. This study assessed the frequency of implant treatments in the esthetic zone of patients presenting to Dental Implant Department of Tehran University during 2002–2012.</p></sec><sec><title>Materials and Methods:</title><p>This descriptive study was conducted on dental records of patients receiving implant treatment during 2002–2012. Patient records were retrieved from the archives and patient demographics, implant characteristics, failure rate, prevalence of complications and implant systems were collected. The data were reported as frequency and percentage.</p></sec><sec><title>Results:</title><p>Of a total of 2,381 implants placed in the mentioned time period, 492 (20.8%) had been placed in the anterior maxilla and 531 (22.3%) had been placed in the anterior mandible from canine to canine. Timing of implant placement was immediate in 12.0%, early in 0.5% and late in 87.4%. Survival rate was 99.1%. Rate of failure was 0.8%. Failure rate was 0.4% in the maxillary and 1.1% in the mandibular canine to canine region. Complications were reported in 10.1% of patients. Rate of complications was 18.3% in the maxillary canine to canine, 8.9% in the mandibular canine to canine, 18.1% in the maxillary first premolar to first premolar and 9.5% in the mandibular first premolar to first premolar. The frequency of bone grafts placed in these areas was 17.6%, 33.9%, 13.6%, 32.1% and 14.3%, respectively.</p></sec><sec><title>Conclusion:</title><p>Of implants placed in our center, around 20% were in the anterior maxilla, and delayed implant placement was the most commonly adopted technique.</p></sec></abstract><kwd-group><kwd>Frequency</kwd><kwd>Esthetic Zone</kwd><kwd>Dental Implant</kwd></kwd-group></article-meta></front><body><sec sec-type="intro"><title>INTRODUCTION</title><p>At present, dental implants are increasingly used for the reconstruction of edentulous areas [<xref rid="B1" ref-type="bibr">1</xref>]. More than one million dental implants are placed annually for patients [<xref rid="B2" ref-type="bibr">2</xref>]. The high success rate of osseointegrated implants has been well documented. Clinical literature reports the five-year success rate of dental implants to be 95–99% [<xref rid="B3" ref-type="bibr">3</xref>–<xref rid="B5" ref-type="bibr">5</xref>]. Due to high demand, improved designs and high-quality products are produced by the dental implant manufacturers, and as the result, dental implants of various designs and brands are available in the dental market. Despite the high success rate, implant treatment requires precise case selection and adequate care must be taken when choosing the implant site, framework design, attachment type, proper length and diameter of implants, prosthetic material and type of prosthesis [<xref rid="B2" ref-type="bibr">2</xref>]. Achieving primary stability, osseointegration during the healing process and functional loading of implants are the three main requirements for the success of dental implant treatment [<xref rid="B1" ref-type="bibr">1</xref>]. In a human mouth, esthetic zone is considered from canine to canine in both the maxilla and mandible. However, based on the smile width, this area may be extended to the first or even second premolars. This zone is particularly important in smile esthetics. Thus, implant placement in the esthetic zone is often more complex and challenging than in other areas of the dental arch. Considering the higher patient demands and expectations from treatments performed in the esthetic zone, it would be beneficial to assess the frequency of implant treatments in the esthetic zone [<xref rid="B4" ref-type="bibr">4</xref>–<xref rid="B6" ref-type="bibr">6</xref>]. The effects of patient demands and socioeconomic status on selection of this treatment need to be evaluated as well. This study aimed to assess the frequency of dental implants placed in the esthetic zone (first premolar to first premolar) of the maxilla and mandible in patients treated in the Dental Implant Department of Tehran University of Medical Sciences during 2002–2012.</p></sec><sec sec-type="materials|methods"><title>MATERIALS AND METHODS</title><p>This descriptive study evaluated the frequency of dental implants placed in the esthetic zone (first premolar to first premolar) of the maxilla and mandible of patients presenting to the Dental Implant Department of Tehran University of Medical Sciences during 2002–2012. Dental records of patients who received dental implants in the esthetic zone during the mentioned time period were retrieved from the archives of the Dental Implant Department and evaluated. The data regarding the patients’ sex, smoking status, systemic diseases (and type of disease), overdenture treatment, implant position in the dental arch, implant system used, bone grafting, implant failure (and the reason), implant type, connection type, implant shape (parallel or tapered), implant diameter, implant platform, implant length, sinus lifting, conduction of guided bone regeneration (GBR), use of platelet rich growth factor (PRGF), conduction of nerve transposition, surgical complications (i.e. sinus perforation and dehiscence), use of biomaterials (and type of it), timing of implant placement (immediate or late) and time of loading (immediate, early, late) were all collected from the patient records. The above-mentioned data were retrieved from the dental records of patients who received implants in the esthetic zone of their maxillary or mandibular arches. The data were reported as frequency (number) and percentage.</p></sec><sec sec-type="results"><title>RESULTS</title><sec><title>Anterior region (first premolar to first premolar) of the maxilla:</title><p>Of 2,381 implants placed for patients during 2002–2012 in the Dental Implant Department, 657 (27.8%) had been placed in the maxillary esthetic zone (first premolar to first premolar). Of the 657 implants, 372 (56.6%) had been placed in females and 283 (43.1%) in males.</p><p>No information was available about the sex of two patients (0.3%). <xref ref-type="table" rid="T1">Table 1</xref> summarizes the results regarding the smoking status and systemic health status of patients. <xref ref-type="table" rid="T2">Table 2</xref> presents the position of implants (n=657).</p><table-wrap id="T1" orientation="portrait" position="float"><label>Table 1.</label><caption><p>Patients’ demographic information</p></caption><table frame="hsides" rules="groups"><thead><tr><th align="center" valign="middle" rowspan="3" colspan="1"></th><th colspan="3" align="center" valign="middle" rowspan="1"><bold>Sex N(%)</bold></th><th colspan="3" align="center" valign="middle" rowspan="1"><bold>Smoking status N(%)</bold></th><th colspan="2" align="center" valign="middle" rowspan="1"><bold>Health status N(%)</bold></th></tr><tr><th colspan="3" align="left" valign="middle" rowspan="1"><hr></hr></th><th colspan="3" align="left" valign="middle" rowspan="1"><hr></hr></th><th colspan="2" align="left" valign="middle" rowspan="1"><hr></hr></th></tr><tr><th align="center" valign="middle" rowspan="1" colspan="1"><bold>Female</bold></th><th align="center" valign="middle" rowspan="1" colspan="1"><bold>Male</bold></th><th align="center" valign="middle" rowspan="1" colspan="1"><bold>No data</bold></th><th align="center" valign="middle" rowspan="1" colspan="1"><bold>Non-smoker</bold></th><th align="center" valign="middle" rowspan="1" colspan="1"><bold>Smoker</bold></th><th align="center" valign="middle" rowspan="1" colspan="1"><bold>No data</bold></th><th align="center" valign="middle" rowspan="1" colspan="1"><bold>Healthy</bold></th><th align="center" valign="middle" rowspan="1" colspan="1"><bold>Systemic disease</bold></th></tr></thead><tbody><tr><td align="left" valign="top" rowspan="1" colspan="1"><bold>Maxilla</bold></td><td align="center" valign="top" rowspan="1" colspan="1">372(56.6)</td><td align="center" valign="top" rowspan="1" colspan="1">283(43.1)</td><td align="center" valign="top" rowspan="1" colspan="1">2(0.3)</td><td align="center" valign="top" rowspan="1" colspan="1">633(96.3)</td><td align="center" valign="top" rowspan="1" colspan="1">22(3.4)</td><td align="center" valign="top" rowspan="1" colspan="1">2(0.3)</td><td align="center" valign="top" rowspan="1" colspan="1">608(92.5)</td><td align="center" valign="top" rowspan="1" colspan="1">47(7.2)</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1"><bold>Mandible</bold></td><td align="center" valign="top" rowspan="1" colspan="1">374(57.5)</td><td align="center" valign="top" rowspan="1" colspan="1">277(42.5)</td><td align="center" valign="top" rowspan="1" colspan="1">0</td><td align="center" valign="top" rowspan="1" colspan="1">626(96.2)</td><td align="center" valign="top" rowspan="1" colspan="1">25(3.8)</td><td align="center" valign="top" rowspan="1" colspan="1">0</td><td align="center" valign="top" rowspan="1" colspan="1">589(90.5)</td><td align="center" valign="top" rowspan="1" colspan="1">62(9.5)</td></tr></tbody></table></table-wrap><table-wrap id="T2" orientation="portrait" position="float"><label>Table 2.</label><caption><p>Position of implants placed in the maxilla and mandible<xref ref-type="table-fn" rid="TFN1">*</xref></p></caption><table frame="hsides" rules="groups"><thead><tr><th align="center" valign="middle" rowspan="1" colspan="1"></th><th align="center" valign="middle" rowspan="1" colspan="1"><bold>Right first premolar</bold></th><th align="center" valign="middle" rowspan="1" colspan="1"><bold>Right canine</bold></th><th align="center" valign="middle" rowspan="1" colspan="1"><bold>Right lateral incisor</bold></th><th align="center" valign="middle" rowspan="1" colspan="1"><bold>Right central incisor</bold></th><th align="center" valign="middle" rowspan="1" colspan="1"><bold>Left central incisor</bold></th><th align="center" valign="middle" rowspan="1" colspan="1"><bold>Left lateral incisor</bold></th><th align="center" valign="middle" rowspan="1" colspan="1"><bold>Left canine</bold></th><th align="center" valign="middle" rowspan="1" colspan="1"><bold>Left first premolar</bold></th><th align="center" valign="middle" rowspan="1" colspan="1"><bold>Total</bold></th></tr></thead><tbody><tr><td align="left" valign="top" rowspan="1" colspan="1"><bold>Mandible</bold></td><td align="center" valign="top" rowspan="1" colspan="1">97(14.8)</td><td align="center" valign="top" rowspan="1" colspan="1">64(9.7)</td><td align="center" valign="top" rowspan="1" colspan="1">99(15.1)</td><td align="center" valign="top" rowspan="1" colspan="1">96(14.6)</td><td align="center" valign="top" rowspan="1" colspan="1">85(12.9)</td><td align="center" valign="top" rowspan="1" colspan="1">92(14.0)</td><td align="center" valign="top" rowspan="1" colspan="1">56(8.5)</td><td align="center" valign="top" rowspan="1" colspan="1">68(10.4)</td><td align="center" valign="top" rowspan="1" colspan="1">657(100)</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1"><bold>Maxilla</bold></td><td align="center" valign="top" rowspan="1" colspan="1">65(10)</td><td align="center" valign="top" rowspan="1" colspan="1">174(26.7)</td><td align="center" valign="top" rowspan="1" colspan="1">66(10.1)</td><td align="center" valign="top" rowspan="1" colspan="1">18(2.8)</td><td align="center" valign="top" rowspan="1" colspan="1">27(4.2)</td><td align="center" valign="top" rowspan="1" colspan="1">53(8.2)</td><td align="center" valign="top" rowspan="1" colspan="1">176(27.0)</td><td align="center" valign="top" rowspan="1" colspan="1">72(11.0)</td><td align="center" valign="top" rowspan="1" colspan="1">651(100)</td></tr></tbody></table><table-wrap-foot><fn id="TFN1"><label>*</label><p>Numbers indicate the quantity and values in parentheses are the percentage</p></fn></table-wrap-foot></table-wrap><p>With regard to the implant system of 657 implants, the most commonly used implant system was ITI (solid screw, standard, standard plus, taper effect, bone level) placed in 300 patients (45.6%). <xref ref-type="table" rid="T3">Table 3</xref> demonstrates the type of connection and shape of implants. In terms of surface type, SLA was the most common surface type observed in 471 cases (71.7%).</p><table-wrap id="T3" orientation="portrait" position="float"><label>Table 3.</label><caption><p>Type of connection and shape of implants placed in the maxilla and mandible</p></caption><table frame="hsides" rules="groups"><thead><tr><th align="center" valign="middle" rowspan="3" colspan="1"></th><th colspan="3" align="center" valign="middle" rowspan="1"><bold>Type of connection N(%)</bold></th><th colspan="3" align="center" valign="middle" rowspan="1"><bold>Implant shape N(%)</bold></th></tr><tr><th colspan="3" align="center" valign="middle" rowspan="1"><hr></hr></th><th colspan="3" align="center" valign="middle" rowspan="1"><hr></hr></th></tr><tr><th align="center" valign="middle" rowspan="1" colspan="1"><bold>Internal</bold></th><th align="center" valign="middle" rowspan="1" colspan="1"><bold>External</bold></th><th align="center" valign="middle" rowspan="1" colspan="1"><bold>No data</bold></th><th align="center" valign="middle" rowspan="1" colspan="1"><bold>Parallel</bold></th><th align="center" valign="middle" rowspan="1" colspan="1"><bold>Tapered</bold></th><th align="center" valign="middle" rowspan="1" colspan="1"><bold>No data</bold></th></tr></thead><tbody><tr><td align="left" valign="top" rowspan="1" colspan="1"><bold>Maxilla</bold></td><td align="center" valign="top" rowspan="1" colspan="1">603(91.8)</td><td align="center" valign="top" rowspan="1" colspan="1">53(8.0)</td><td align="center" valign="top" rowspan="1" colspan="1">1(0.2)</td><td align="center" valign="top" rowspan="1" colspan="1">451(68.6)</td><td align="center" valign="top" rowspan="1" colspan="1">205(31.2)</td><td align="center" valign="top" rowspan="1" colspan="1">0</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1"><bold>Mandible</bold></td><td align="center" valign="top" rowspan="1" colspan="1">613(94.2)</td><td align="center" valign="top" rowspan="1" colspan="1">38(5.8)</td><td align="center" valign="top" rowspan="1" colspan="1">0</td><td align="center" valign="top" rowspan="1" colspan="1">508(78.0)</td><td align="center" valign="top" rowspan="1" colspan="1">143(22.0)</td><td align="center" valign="top" rowspan="1" colspan="1">1(0.2)</td></tr></tbody></table></table-wrap><p>The most frequently used implants (n=167, 25.4%) had 4.1mm diameter and RN platform had the highest frequency (n=238, 36.2%). The most commonly used implants had 12mm length (n=266, 40.4%). Data regarding implant placement (immediate/early/late) and implant loading (immediate/delayed) are presented in <xref ref-type="table" rid="T4">Table 4</xref>.</p><table-wrap id="T4" orientation="portrait" position="float"><label>Table 4.</label><caption><p>Timing of implant placement and loading in the maxilla and mandible</p></caption><table frame="hsides" rules="groups"><thead><tr><th align="center" valign="middle" rowspan="3" colspan="1"></th><th colspan="4" align="center" valign="middle" rowspan="1"><bold>Implant placement N(%)</bold></th><th colspan="3" align="center" valign="middle" rowspan="1"><bold>Implant loading N(%)</bold></th></tr><tr><th colspan="4" align="center" valign="middle" rowspan="1"><hr></hr></th><th colspan="3" align="center" valign="middle" rowspan="1"><hr></hr></th></tr><tr><th align="center" valign="middle" rowspan="1" colspan="1"><bold>Immediate</bold></th><th align="center" valign="middle" rowspan="1" colspan="1"><bold>Early</bold></th><th align="center" valign="middle" rowspan="1" colspan="1"><bold>Late</bold></th><th align="center" valign="middle" rowspan="1" colspan="1"><bold>No information</bold></th><th align="center" valign="middle" rowspan="1" colspan="1"><bold>Immediate</bold></th><th align="center" valign="middle" rowspan="1" colspan="1"><bold>Delayed</bold></th><th align="center" valign="middle" rowspan="1" colspan="1"><bold>No information</bold></th></tr></thead><tbody><tr><td align="left" valign="top" rowspan="1" colspan="1"><bold>Maxilla</bold></td><td align="center" valign="top" rowspan="1" colspan="1">151(23.0)</td><td align="center" valign="top" rowspan="1" colspan="1">5(0.7)</td><td align="center" valign="top" rowspan="1" colspan="1">500(76.1)</td><td align="center" valign="top" rowspan="1" colspan="1">1(0.2)</td><td align="center" valign="top" rowspan="1" colspan="1">3(0.4)</td><td align="center" valign="top" rowspan="1" colspan="1">653(99.4)</td><td align="center" valign="top" rowspan="1" colspan="1">1(0.2)</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1"><bold>Mandible</bold></td><td align="center" valign="top" rowspan="1" colspan="1">54(8.3)</td><td align="center" valign="top" rowspan="1" colspan="1">1(0.2)</td><td align="center" valign="top" rowspan="1" colspan="1">596(91.5)</td><td align="center" valign="top" rowspan="1" colspan="1">0</td><td align="center" valign="top" rowspan="1" colspan="1">1(0.2)</td><td align="center" valign="top" rowspan="1" colspan="1">650(99.8)</td><td align="center" valign="top" rowspan="1" colspan="1">0</td></tr></tbody></table></table-wrap><p>Sinus lift surgery was performed by open-technique in seven patients (1.1%) and by closed technique in nine patients (1.3%). No information was available in this respect for one patient (0.2%). Also, GBR was performed in 239 patients (36.3%) and biomaterials had been used in 248 (37.8%) out of 657 cases. The most commonly used biomaterials were Bio-Oss+ BioGide membrane (n=66) and Bio-Oss (n=49). No information was available in this respect for one case (0.2%). Implant failure rate was 0.4% (three implants) in the maxilla. No complications were reported in 537 (81.7%) patients while complications occurred in 119 cases (18.1%).</p><p>Dehiscence was the most common complication and was reported in 93 cases.</p></sec><sec><title>Anterior region (first premolar to first premolar) of the mandible:</title><p>Of 2,381 implants placed for patients during 2002–2012 in the Dental Implant Department, 651 (27.3%) had been placed in the anterior mandible (first premolar to first premolar). Of 651 implants, 374 (57.5%) had been placed in females and 277 (42.5%) in males. <xref ref-type="table" rid="T1">Table 1</xref> summarizes the results regarding the smoking status and systemic health status of patients. <xref ref-type="table" rid="T2">Table 2</xref> presents the position of implants (n=651).</p><p>With regard to the implant system of 651 implants, the most commonly used implant system was Straumann-ITI (solid screw, standard, standard plus, taper effect, bone level) placed in 389 patients (59.7%). In terms of surface type, SLA was the most common surface type observed in 534 cases (82.0%). <xref ref-type="table" rid="T3">Table 3</xref> demonstrates the type of connection and shape of implants.</p><p>The most frequently used implants (n=278, 42.7%) had 4.1mm diameter. In terms of platform, RN platform had the highest frequency (n=360, 55.3%). The most commonly used implants had 12mm length (n=313, 48.0%).</p><p>Data regarding implant placement (immediate/early/late) and implant loading (immediate/delayed) are presented in <xref ref-type="table" rid="T4">Table 4</xref>. Also, GBR was performed in 112 cases (17.2%). No patient received PRGF. Nerve transposition had been done in only one case (0.2%).</p><p>Biomaterials had been used in 120 (18.4%) out of 651 cases. The most commonly used biomaterials were Bio-Oss (n=29) and autogenous bone (n=18). Implant failure rate was 0.9% (six implants) in the mandible. No complications were reported in 589 (90.5%) cases while complications occurred in 62 cases (9.5%). Dehiscence was the most common complication reported in 55 cases.</p></sec></sec><sec sec-type="discussion"><title>DISCUSSION</title><p>Of 2,381 implants, 657 (27.8%) had been placed in the anterior maxilla and 651 (27.3%) in the anterior mandible (first premolar to first premolar). The high prevalence of implant placement in this area indicates the high incidence of anterior tooth loss probably due to poor oral hygiene or trauma. Tooth loss in the aesthetic zone has significant adverse effects on the speech and facial esthetics of patients. Patients mostly look for the best available option for replacement of the lost tooth in the esthetic zone. An interesting finding of this study was higher number of female patients receiving dental implants in the esthetic zone. This finding indicates the higher esthetic demands of female patients. Due to the excellent properties of dental implants in terms of esthetics and function, they are increasingly used for the replacement of the lost teeth particularly in the anterior region.</p><p>Bragger et al, in 2005 also reported the higher frequency of female patients requiring dental implants (55 females versus 34 males) [<xref rid="B6" ref-type="bibr">6</xref>]. However, Ko et al, in 2006 evaluated the clinical function of two-stage dental implants placed in patients presenting to two dental centers in South Korea and reported that the frequency of male patients receiving implants was higher than females [<xref rid="B7" ref-type="bibr">7</xref>]. In our study, 7.2% of patients receiving implants in the anterior maxilla and 9.5% of those receiving implants in the anterior mandible (first premolar to first premolar) had systemic diseases. Ko et al, in 2006 demonstrated that 9% of patients receiving dental implants were suffering from systemic conditions [<xref rid="B7" ref-type="bibr">7</xref>]. Underlying systemic diseases are among the major risk factors related to implant failure. Thus, systemic conditions must be evaluated and properly treated or managed prior to implant placement in order to decrease the risk of failure. In our study, 3.4% of those receiving implants in the maxillary esthetic zone and 3.8% of those receiving implants in the anterior mandible were smokers. Such insignificant prevalence of smoking may be among the factors contributing to the high success rate of implant treatments in our study. However, it may also indicate inaccurate history taking or dishonesty of patients. Failure of dental implants can be divided into two groups of early and late failures. Early failures occur during the time period following the surgical procedure until prosthetic loading due to impaired healing and lack of osseointegration. Late failures occur as the result of development of peri-implantitis. The effect of smoking is usually late [<xref rid="B8" ref-type="bibr">8</xref>].</p><p>Immediate implant placement may restore soft tissue support and increase treatment success due to the favorable contour of soft and hard tissues. If tissue regeneration is not required and the area is free from acute infection, immediate implant placement may be the treatment of choice. The main criteria for immediate implant placement include: ideal contour of the hard and soft tissues, esthetic needs of the area, adequate bone health and volume (in terms of quantity and quality) at the site, absence of acute infection and ideal root position and angulation (significant change in the direction/orientation of implant in the socket is an important issue). Immediate implant placement is not the choice of treatment when the adjacent bone is traumatized during the process of root extraction or when the buccal plate is removed [<xref rid="B9" ref-type="bibr">9</xref>].</p><p>Based on the current study results, of 2,381 implants placed in the maxillary esthetic zone, 23.0% had immediate, 0.7% had early and 76.1% had late placement. In the mandible, 8.3% had immediate, 0.2% had early and 91.5% had late placement. Some studies are in favor of immediate implant placement in the mandibular anterior region due to adequate primary stability and advantages of one-stage surgery as well as shorter duration of treatment. However, this is feasible only if the patient has perfect general health status and the mandibular bone is adequate for receiving four to six fixtures with a minimum length of 10mm and diameter of 3.75 to 4mm [<xref rid="B10" ref-type="bibr">10</xref>]. Based on our results, 32.1% of cases receiving implants in the maxillary esthetic zone and 14.3% of those receiving implants in the anterior mandible had bone grafts, which indicates that the bone deficiency could be more prevalent in the anterior maxilla than in the mandible. In this study, the failure rate of implants was 0.4% in the anterior maxilla and 0.9% in the anterior mandible and the prevalence of complications was 18.1% in the anterior maxilla and 9.5% in the anterior mandible. The authors believe that such a high survival rate of implants could be related to the high compliance of clinicians in dental implant department to the scientific aspects of implant dentistry. However, this high survival rate in the anterior region may also indicate lack of regular follow-ups and lack of information regarding the survival or failure of implants that could make the patient files incomplete for data analysis. Despite the diversity in types of implants, the reported success rates in most studies have been over 90%. In a study by Becker et al, in 2005 the two to three-year survival rate of implants has reported to be 97.2% [<xref rid="B11" ref-type="bibr">11</xref>]. In a study by Raghoebar et al, in 2003 the survival rate of implants and prosthesis was 93% [<xref rid="B12" ref-type="bibr">12</xref>]. This rate has reported to be 94.3% and 96% in other studies [<xref rid="B13" ref-type="bibr">13</xref>,<xref rid="B14" ref-type="bibr">14</xref>]. Ko et al, in 2006 reported a success rate of 97.9% after 4.5 years [<xref rid="B7" ref-type="bibr">7</xref>]. Carr et al, in 2003 evaluated the clinical function of one-stage implants and reported their survival rate to be 97% [<xref rid="B15" ref-type="bibr">15</xref>]. Strauman-ITI was the most commonly used implant system (solid screw, standard, standard plus, taper effect, bone level) followed by Nobel Replace Select, Dentsply-Xive and Implantium; and all demonstrated good treatment outcomes. Several manufacturers produce dental implants of optimal quality. In the maxillary and mandibular anterior region, the frequency of internal and external connections used was 91.8% and 8.0%, and 94.2% and 5.8%, respectively; these values indicate that the internal connection was more popular among the clinicians. However, there is no any adverse effect with regard to the use of external connection based on the obtained data from this study. The prevalence of sinus lifting was 2.4% in the anterior maxilla and in the first premolar sites. Presence of the maxillary sinus over the posterior maxilla usually decreases the available bone height for implant placement [<xref rid="B16" ref-type="bibr">16</xref>]. Such anatomical limitations can compromise successful osseointegration of implants [<xref rid="B17" ref-type="bibr">17</xref>]. Sinus augmentation surgery is performed to enhance implant placement in resorbed posterior maxilla. It is now a well-accepted technique prior to implant surgery [<xref rid="B17" ref-type="bibr">17</xref>] allowing the insertion of implants of proper length. In cases with severely atrophic maxillary ridge, local augmentation technique must be necessarily performed in order to prevent complications such as inadequate crown/root ratio [<xref rid="B18" ref-type="bibr">18</xref>]; since in this study most implants placed in the anterior zone were in 12mm range, the authors believe this could be one of the influential factors in high survival rate of implants. Although the prevalence of biomaterials used was low in our study, many researchers use tissue regeneration techniques in order to enhance ridge volume and induce new bone formation before implant placement. Other researchers recommend sinus augmentation techniques and ridge reconstruction by using short implants to increase vertical bone height. The authors believe that assessment of the prevalence of complications and success of implants at different areas can help clinicians select the most appropriate implant type available in the market and find factors responsible for implant failure. Such studies can also help clinicians assess the accuracy of the reported success rates. However, it should be noted that these studies must be of optimal quality and have adequate sample size, and long enough follow up periods in order for the results to be generalizable. Although clinical trials are methodologically the strongest studies in medical sciences, it should be noted that they are conducted under controlled, ideal clinical settings that may limit their generalizability. 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