Evaluation on the efficacy and safety of calcium metaphosphate coated fixture
Identifieur interne : 002E83 ( Pmc/Corpus ); précédent : 002E82; suivant : 002E84Evaluation on the efficacy and safety of calcium metaphosphate coated fixture
Auteurs : In-Ho Cho ; Jae-Hoon Lee ; Young-Gyun Song ; Young-Mi Kim ; So-Young JeonSource :
- The Journal of Advanced Prosthodontics [ 2005-7806 ] ; 2013.
Abstract
The purpose of this study was to assess the difference in efficacy between calcium metaphosphate (CMP)-coated implant fixtures and conventional resorbable blasted media (RBM) processed implant fixtures.
This study targeted 50 implants from 44 patients who visited Dankook University Dental Hospital. Implantations were done separately for RBM treated and CMP-coated implants, although their design was the same. Calcium metaphosphate has a quicker biodegradation process through hydrolysis compared to other phosphate calcium groups. For the first year of the implantation, the resorption volume of marginal bone analyzed via radiography and perio-test value were measured, under the check plan. Their analyses were composed of a non-inferiority trials test. A 95% level of reliability was used.
In the comparative analysis of the resorption volume of marginal bone and the perio-test value, no statistically significant difference was found between the CMP-coated implants and RBM implants.
One year after the implant placement, CMP-coated implants were found not to be inferior to the conventional RBM implants.
Url:
DOI: 10.4047/jap.2013.5.2.172
PubMed: 23755344
PubMed Central: 3675291
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PMC:3675291Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Evaluation on the efficacy and safety of calcium metaphosphate coated fixture</title><author><name sortKey="Cho, In Ho" sort="Cho, In Ho" uniqKey="Cho I" first="In-Ho" last="Cho">In-Ho Cho</name><affiliation><nlm:aff id="A1">Department of Prosthodontics, College of Dentistry, Dankook University, Cheonan, Republic of Korea.</nlm:aff></affiliation></author><author><name sortKey="Lee, Jae Hoon" sort="Lee, Jae Hoon" uniqKey="Lee J" first="Jae-Hoon" last="Lee">Jae-Hoon Lee</name><affiliation><nlm:aff id="A2">Department of Oral and Maxillofacial Surgery, College of Dentistry, Dankook University, Cheonan, Republic of Korea.</nlm:aff></affiliation></author><author><name sortKey="Song, Young Gyun" sort="Song, Young Gyun" uniqKey="Song Y" first="Young-Gyun" last="Song">Young-Gyun Song</name><affiliation><nlm:aff id="A1">Department of Prosthodontics, College of Dentistry, Dankook University, Cheonan, Republic of Korea.</nlm:aff></affiliation></author><author><name sortKey="Kim, Young Mi" sort="Kim, Young Mi" uniqKey="Kim Y" first="Young-Mi" last="Kim">Young-Mi Kim</name><affiliation><nlm:aff id="A3">Dankook University Dental Hospital, Cheonan, Republic of Korea.</nlm:aff></affiliation></author><author><name sortKey="Jeon, So Young" sort="Jeon, So Young" uniqKey="Jeon S" first="So-Young" last="Jeon">So-Young Jeon</name><affiliation><nlm:aff id="A3">Dankook University Dental Hospital, Cheonan, Republic of Korea.</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">23755344</idno><idno type="pmc">3675291</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3675291</idno><idno type="RBID">PMC:3675291</idno><idno type="doi">10.4047/jap.2013.5.2.172</idno><date when="2013">2013</date><idno type="wicri:Area/Pmc/Corpus">002E83</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002E83</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Evaluation on the efficacy and safety of calcium metaphosphate coated fixture</title><author><name sortKey="Cho, In Ho" sort="Cho, In Ho" uniqKey="Cho I" first="In-Ho" last="Cho">In-Ho Cho</name><affiliation><nlm:aff id="A1">Department of Prosthodontics, College of Dentistry, Dankook University, Cheonan, Republic of Korea.</nlm:aff></affiliation></author><author><name sortKey="Lee, Jae Hoon" sort="Lee, Jae Hoon" uniqKey="Lee J" first="Jae-Hoon" last="Lee">Jae-Hoon Lee</name><affiliation><nlm:aff id="A2">Department of Oral and Maxillofacial Surgery, College of Dentistry, Dankook University, Cheonan, Republic of Korea.</nlm:aff></affiliation></author><author><name sortKey="Song, Young Gyun" sort="Song, Young Gyun" uniqKey="Song Y" first="Young-Gyun" last="Song">Young-Gyun Song</name><affiliation><nlm:aff id="A1">Department of Prosthodontics, College of Dentistry, Dankook University, Cheonan, Republic of Korea.</nlm:aff></affiliation></author><author><name sortKey="Kim, Young Mi" sort="Kim, Young Mi" uniqKey="Kim Y" first="Young-Mi" last="Kim">Young-Mi Kim</name><affiliation><nlm:aff id="A3">Dankook University Dental Hospital, Cheonan, Republic of Korea.</nlm:aff></affiliation></author><author><name sortKey="Jeon, So Young" sort="Jeon, So Young" uniqKey="Jeon S" first="So-Young" last="Jeon">So-Young Jeon</name><affiliation><nlm:aff id="A3">Dankook University Dental Hospital, Cheonan, Republic of Korea.</nlm:aff></affiliation></author></analytic><series><title level="j">The Journal of Advanced Prosthodontics</title><idno type="ISSN">2005-7806</idno><idno type="eISSN">2005-7814</idno><imprint><date when="2013">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>PURPOSE</title><p>The purpose of this study was to assess the difference in efficacy between calcium metaphosphate (CMP)-coated implant fixtures and conventional resorbable blasted media (RBM) processed implant fixtures.</p></sec><sec><title>MATERIALS AND METHODS</title><p>This study targeted 50 implants from 44 patients who visited Dankook University Dental Hospital. Implantations were done separately for RBM treated and CMP-coated implants, although their design was the same. Calcium metaphosphate has a quicker biodegradation process through hydrolysis compared to other phosphate calcium groups. For the first year of the implantation, the resorption volume of marginal bone analyzed via radiography and perio-test value were measured, under the check plan. Their analyses were composed of a non-inferiority trials test. A 95% level of reliability was used.</p></sec><sec><title>RESULTS</title><p>In the comparative analysis of the resorption volume of marginal bone and the perio-test value, no statistically significant difference was found between the CMP-coated implants and RBM implants.</p></sec><sec><title>CONCLUSION</title><p>One year after the implant placement, CMP-coated implants were found not to be inferior to the conventional RBM implants.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Albrektsson, T" uniqKey="Albrektsson T">T Albrektsson</name></author><author><name sortKey="Sennerby, L" uniqKey="Sennerby L">L Sennerby</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Eckert, Se" uniqKey="Eckert S">SE Eckert</name></author><author><name sortKey="Parein, A" uniqKey="Parein A">A Parein</name></author><author><name sortKey="Myshin, Hl" uniqKey="Myshin H">HL Myshin</name></author><author><name 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<front><journal-meta><journal-id journal-id-type="nlm-ta">J Adv Prosthodont</journal-id><journal-id journal-id-type="iso-abbrev">J Adv Prosthodont</journal-id><journal-id journal-id-type="publisher-id">JAP</journal-id><journal-title-group><journal-title>The Journal of Advanced Prosthodontics</journal-title></journal-title-group><issn pub-type="ppub">2005-7806</issn><issn pub-type="epub">2005-7814</issn><publisher><publisher-name>The Korean Academy of Prosthodontics</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">23755344</article-id><article-id pub-id-type="pmc">3675291</article-id><article-id pub-id-type="doi">10.4047/jap.2013.5.2.172</article-id><article-categories><subj-group subj-group-type="heading"><subject>Original Article</subject></subj-group></article-categories><title-group><article-title>Evaluation on the efficacy and safety of calcium metaphosphate coated fixture</article-title></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name><surname>Cho</surname><given-names>In-Ho</given-names></name><degrees>DDS</degrees><degrees>MSD</degrees><degrees>PhD</degrees><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Lee</surname><given-names>Jae-Hoon</given-names></name><degrees>DDS</degrees><degrees>MSD</degrees><degrees>PhD</degrees><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Song</surname><given-names>Young-Gyun</given-names></name><degrees>DDS</degrees><degrees>MSD</degrees><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Kim</surname><given-names>Young-Mi</given-names></name><degrees>MPH</degrees><xref ref-type="aff" rid="A3">3</xref></contrib><contrib contrib-type="author"><name><surname>Jeon</surname><given-names>So-Young</given-names></name><degrees>MHA</degrees><xref ref-type="aff" rid="A3">3</xref></contrib></contrib-group><aff id="A1"><label>1</label>Department of Prosthodontics, College of Dentistry, Dankook University, Cheonan, Republic of Korea.</aff><aff id="A2"><label>2</label>Department of Oral and Maxillofacial Surgery, College of Dentistry, Dankook University, Cheonan, Republic of Korea.</aff><aff id="A3"><label>3</label>Dankook University Dental Hospital, Cheonan, Republic of Korea.</aff><author-notes><corresp>Corresponding author: In-Ho Cho. Department of Prosthodontics, College of Dentistry, Dankook University, 119, Dandae-ro, Dongnam-gu, Cheonan-si, Chungcheongnam-do, 330-992, Republic of Korea. Tel. 82415500254: <email>cho8511@dankook.ac.kr</email></corresp></author-notes><pub-date pub-type="ppub"><month>5</month><year>2013</year></pub-date><pub-date pub-type="epub"><day>30</day><month>5</month><year>2013</year></pub-date><volume>5</volume><issue>2</issue><fpage>172</fpage><lpage>178</lpage><history><date date-type="received"><day>05</day><month>11</month><year>2012</year></date><date date-type="rev-recd"><day>24</day><month>4</month><year>2013</year></date><date date-type="accepted"><day>25</day><month>4</month><year>2013</year></date></history><permissions><copyright-statement>© 2013 The Korean Academy of Prosthodontics</copyright-statement><copyright-year>2013</copyright-year><license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by-nc/3.0/"><license-p>This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (<ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by-nc/3.0/">http://creativecommons.org/licenses/by-nc/3.0/</ext-link>) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.</license-p></license></permissions><abstract><sec><title>PURPOSE</title><p>The purpose of this study was to assess the difference in efficacy between calcium metaphosphate (CMP)-coated implant fixtures and conventional resorbable blasted media (RBM) processed implant fixtures.</p></sec><sec><title>MATERIALS AND METHODS</title><p>This study targeted 50 implants from 44 patients who visited Dankook University Dental Hospital. Implantations were done separately for RBM treated and CMP-coated implants, although their design was the same. Calcium metaphosphate has a quicker biodegradation process through hydrolysis compared to other phosphate calcium groups. For the first year of the implantation, the resorption volume of marginal bone analyzed via radiography and perio-test value were measured, under the check plan. Their analyses were composed of a non-inferiority trials test. A 95% level of reliability was used.</p></sec><sec><title>RESULTS</title><p>In the comparative analysis of the resorption volume of marginal bone and the perio-test value, no statistically significant difference was found between the CMP-coated implants and RBM implants.</p></sec><sec><title>CONCLUSION</title><p>One year after the implant placement, CMP-coated implants were found not to be inferior to the conventional RBM implants.</p></sec></abstract><kwd-group><kwd>Calcium metaphoaphate (CMP)</kwd><kwd>Implant surface</kwd><kwd>Implant stability</kwd></kwd-group></article-meta></front><body><sec><title>INTRODUCTION</title><p>Since Machined surface titanium implants were introduced by Brånemark, they have been used not only for fully edentulous patients but also for those who are partially edentulous for functional restoration.<xref ref-type="bibr" rid="B1">1</xref>,<xref ref-type="bibr" rid="B2">2</xref> More types of implants have been developed including subperiosteal implants and blade-vent implants, although root-type osseointegrated implants are chiefly used at present. Albrektsson defined osseointegration as: implant and bone tissue making direct contact without connective tissue and movement when observed under an optic microscope.<xref ref-type="bibr" rid="B3">3</xref> He also found that implant material, design, surface, bone condition, surgical method, and loading condition are crucial factors in achieving osseointegration. In particular, implant material, design, and surface are believed to be related to implant quality; active studies on implant surface and design aspects have been ongoing. A major change in implant surface is the shift from smooth and glossy surface to rough. Carlsson et al.<xref ref-type="bibr" rid="B4">4</xref> found that implants with irregular surfaces form stronger mechanical adhesion with the surrounding bone tissue than those with glossy surface and the mechanical adhesion at the early stage can result in a stable osseointegration by preventing a fine movement. As methods of processing a glossy surface into a rough one, coating, polishing, blasting, etching, and anodic oxidation are used; some of these are under research.<xref ref-type="bibr" rid="B5">5</xref> Hydroxyapatite is akin to an ingredient of bone tissue; it is known for its affinity with the implantbone interface.<xref ref-type="bibr" rid="B6">6</xref> In terms of the coating method with hydroxyapatite onto implants, plasma spraying, the most common method, dipping, electrodeposition, and pulsed-laser deposition are used.</p><p>The surface of hydroxyapatite-coated implants has generally been formed by spraying hydroxyapatite powder at high pressure onto a titanium surface to create a hydroxyapatite layer.<xref ref-type="bibr" rid="B7">7</xref> Based on the results of a long-term animal test, however, the hydroxyapatite-coated layer does not biodegrade even after a considerable period of time, retaining its adhesion with bone tissue instead. Nonetheless, concerns over the detachment of the interface between the metal implant and the hydroxyapatite-coated layer have been reported. Some studies seeking to resolve this problem have been underway.<xref ref-type="bibr" rid="B8">8</xref> If quickly degradable substances such as tricalcium phosphate (TCP) or calcium metaphosphate (CMP) are coated onto implants, prompt adhesion with bone tissue is realized, and biodegradation occurs along with the growth of the bone tissue in a relatively short time; thus inducing direct adhesion with implant fixtures. CMP ([Ca(PO<sub>3</sub>)<sub>2</sub>]<sub>n</sub>) has a polymer structure consisting of phosphate group chains and is involved in a quicker biodegradation process through hydrolysis compared to other phosphate calcium groups.<xref ref-type="bibr" rid="B9">9</xref>,<xref ref-type="bibr" rid="B10">10</xref> Those who conformed to the following criteria were excluded: <italic>In vitro</italic> study about biocompatibility of CMP with human bone marrow stromal cells, CMP disks produce better results than HA disks.<xref ref-type="bibr" rid="B11">11</xref> The most commonly used CMP coating procedure is a dipspin coating technique.<xref ref-type="bibr" rid="B12">12</xref> Implants that were coated this way showed increased or constant ISQ values during the initial healing period in animal Experiment.<xref ref-type="bibr" rid="B13">13</xref></p><p>Accordingly, this study compared the CMP-coated fixtures and powdered hydroxyapatite-blasting RBM (Resorbable Blast Media) fixtures placed in the oral cavities of patients.</p></sec><sec sec-type="materials|methods"><title>MATERIALS AND METHODS</title><p>The project for this study was given an official recognition by the Ethics Committee of Dankook University (IRB no. 2004005), being also in compliance with the helsinki declaration. Among those who visited Dankook Univ. Dental Hospital for implant treatment, the 50 implants from 44 patients who needed the placement of one or two implants (next to each other) were targeted. Those who conformed to the following criteria were excluded:</p><p>Criteria for test target assignment<xref ref-type="bibr" rid="B14">14</xref>,<xref ref-type="bibr" rid="B15">15</xref> is as follows. Patients who lost their maxillary and mandibular teeth and wish to get implant treatment instead of having their adjacent teeth cut and wearing a removable prosthesis agreed to participate in the clinical test, signed a tester agreement, and met the following criteria (cases with deficient antagonist teeth on the implant site were excluded; note, however, that patients who had planned the prosthetic restoration of antagonist teeth were included in the test): patients whose jawbone has stopped growing, good condition of oral cavity and those with clear desire for implant treatment.</p><p>The following cases did not fit this clinical test, and they were considered absolute taboo cases for implant treatment: pregnant women, patients with recent episode of myocardial infarction, patients with internal ailment that cannot be controlled, patients with hemorrhagic ailment, patients who have mental illness, patients who are not cooperative, patients who are allergic to implant material, patients in a growth phase and patients who are uncertain about implant treatment.</p><p>Random method for selection and the determination of a comparison group is as follws. The selection of non-submerged RBM dental implant SSII or CMP-coated implant SSII Type was determined randomly according to specific allocation chart. A research nurse managed the chart; once the final selection of testees was made, grouping was done based on the chart. A testee identification code was then marked in the chart. The test group and a control group were randomly determined through stratified block randomization. For the selection, the test group was selected in a number that was twice that of the control group. With regard to the intermaxillary ratio, the maxilla was selected for at least 30% of the total; for the anterior versus posterior, the anterior was selected for at least 15%.</p><p>For the basic shape of implants, SS II systems (Osstem, Seoul, Korea) were used. For the control group, the RBM surface blasted with hydroxyapatite [Ca<sub>10</sub>(PO<sub>4</sub>)<sub>6</sub>(OH)<sub>2</sub>] powder was used to increase the surface roughness. Similar to the control group, CMP-coated products were used onto the RBM-processed surface for the test group. The CMP solutions were mixed Calcium nitrate tetra hydrate [Ca(NO<sub>3</sub>)<sub>2</sub>4H<sub>2</sub>O] and triethyl phosphite [P(OC<sub>2</sub>H<sub>5</sub>)<sub>3</sub>] in methanol. The resultant CMP sol-gel was Ca/P molar ratio of 0.5. The RBM surface implants were dipped in CMP solution and sintered at 630℃ for CMP-coated products.</p><p>Implant placement was carried out according to the recommendations of the manufacturer. Based on the planned procedure, routine checkups and prosthetic creation were then done. The procedure is described below (<xref ref-type="table" rid="T1">Table 1</xref>).</p><p>One year after the placement of fixtures, Periotest (Siemens AG, Bensheim, Germany) was used. The Periotest value (PTV) was measured at the prosthetic level (<xref ref-type="fig" rid="F1">Fig. 1</xref>). To reduce the measurement error, measurement was repeated 3 times until the same value was measured. For the radiographic scan, Kodak insight film (Kodak Co, California, USA) placed perpendicularly from the implant fixtures was used (<xref ref-type="fig" rid="F2">Fig. 2</xref>). Afterward, using an Epson expression 1600 pro scanner (Seiko Epson Co., Nagano, Japan), scanning was done at 1,200 dpi resolution. A 1,024 × 765-pixel Syncmaster 155MP monitor (Samsung Electronics, Suwon, Korea) was used for all measurements by one person. The measurements for bone absorption were based on the first screw helix of implant fixtures and were revised with the pitch of the fixtures as referenced.</p><p>For the evaluation of the success rate of this clinical test, all implants placed in the testees were targeted. One year after the implant placement, observations were made on abnormal reactions including implant looseness, discomfort, radiographic image of area around the implant fixtures, and absorption of marginal bone. Occlusal assessments were then made, and patients received instruction on oral hygiene.</p><p>Major evaluation factor used to determine the success or failure of dental implants during the first full year after the implant surgery is as follows. Functioning implants are classified into the following 4 types:<xref ref-type="bibr" rid="B16">16</xref> "Unaccounted" indicates those implants that failed the observations for unknown reason. "Failure" is implants that were removed for some reason. "Survival" is group except 1 and 2. "Success" is group conforming to the following success criteria. Success criteria for dental (osseointegrated) implants is as follows.<xref ref-type="bibr" rid="B17">17</xref>,<xref ref-type="bibr" rid="B18">18</xref> First, there is no consistent or non-reciprocal discomfort, pain, or abnormal sensations. Secondly, there is no recurrence of peri-implant inflammation accompanying abscess. Thirdly, there is no mobility. Lastly, there should be no peri-implant radiographic lesion. If any of the above criteria is not met, the group is considered a failure.</p><p>The secondary factors of this clinical test were used as reference to determine the success rate through diagnostic parameters that verify the factors affecting the result (success or failure) of implant treatment. It should be less than 1 mm during the first full year after implant placement and less than 0.2 mm a year thereafter.<xref ref-type="bibr" rid="B19">19</xref>-<xref ref-type="bibr" rid="B22">22</xref> The degree of osteolysis is evaluated based on the periapical radiography. The group is considered a failure if it does not conform to these criteria. This case is included in the survival rate but not in the success rate. The evaluation of bone quality is based on both the sensation during bone drilling for implant surgery and panoramic radiography.<xref ref-type="bibr" rid="B23">23</xref></p><p>All implants should have no mobility. Solid bonding is tantamount to zero clinical mobility when tested vertically or horizontally below 500 g; this is similar to the manner of assessing that of teeth. The absence of clinically observable mobility does not mean zero actual mobility. A natural tooth with mobility actually has 56-73 µm horizontal mobility. A healthy implant moves less than 75 µm, and its clinical mobility is 0.<xref ref-type="bibr" rid="B24">24</xref> As a non-destructive test that is clinically available for the examination of osseointegration and stability of implants, Perio-test measurement was included. The existence of implant mobility means failure of osseointegration; since a PTV value is not absolute, however, assessment should be done in connection with the clinical and radiographic index. There should be no suppuration around the implants.<xref ref-type="bibr" rid="B25">25</xref></p><p>Occlusion evaluation is as follows<xref ref-type="bibr" rid="B26">26</xref>,<xref ref-type="bibr" rid="B27">27</xref> : From a long-term perspective, occlusal stability can improve the prognosis of implant treatment by preventing prosthetic overload. For adequate occlusal adjustment, tension and deformation occurring from the bone-implant contact point should be within the range of biological stimulation. However implants have no periapical membrane. Thus, patients need to be advised on light tapping and strong tooth clenching during occlusal adjustment. Adjacent teeth and early occlusal contact should be eliminated completely. Using Shimstock (8 µm thick), evaluate the fit or misfit. When light clenching is applied using shim-stock, 1-2 sheets of Shimstock slip out of the prosthetic implants. When biting is applied onto two overlapped sheets, adjust the occlusion so that it sticks. The thickness of 2 sheets is 16 µm, and that of 3 sheets, 24 µm. Clenching with 3 sheets is required to prevent excessive occlusal gap. In other words, light clenching makes shim-stock slip away freely; heavy contact makes it slip away even in cases of slight resistance. When light tapping is applied after Accu-Film II (Red/Black-two-sided) articulating paper is inserted, the occlusal contact on the implant prosthesis needs to be reduced if the same extent of occlusal contact on the implant and natural teeth is detected. Again, when 1 sheet of Accu-Film II is clenched with light occlusal contact, there should be no contact on the implant. During the vertical movements of the mandibular jaw, if natural teeth with periodontal ligament do not move down vertically, a fine occlusal gap measuring approximately 20 µm (Accu-Film II thickness) between the implant prosthesis and the antagonist tooth is required to prevent overload on the implant. This is because it protects from 8-28 µm vertical tooth movement that may occur during strong mastication. When stronger occlusal contact is formed, light occlusal contact should be achieved onto the implant prosthesis. In other words, the measurement should ensure that light occlusal contact indentation is formed compared to adjacent natural teeth.</p><p>For all measurements, Windows SPSS V. 12.0 (SPSS, Inc., Chicago, IL, USA) was used for statistical processing. With regard to the comparison of the mean values of the absorption level of marginal boneboth in the control group and the test group for each period and PTV one year after the placement of fixtures, the independent t-test was used to verify the significance. For the time-based difference in the absorption of marginal bone, the significance was verified through the paired t-test. In particular, for the time-based difference comparison, the maxillae and the mandibles were divided according to Visit 8. A 95% level of reliability was used.</p></sec><sec sec-type="results"><title>RESULTS</title><p>One year after the placement of fixtures, the mean PTV of the test group was found to be higher than that of the control group. In the independent t-test result, however, no statistically significant difference was found (<xref ref-type="table" rid="T2">Table 2</xref>).</p><p>The absorption levels of marginal bone in the test group for each period were lower than those of the control group; in the independent t-test result, however, no statistically significant difference was found in all periods (<xref ref-type="table" rid="T3">Table 3</xref>).</p><p>For the period-based difference in the mean absorption levels of marginal bone particularly in the paired t-test result, a statistically significant difference was detected with the test group of mandibles only between Visit 3 and Visit 5 (<xref ref-type="table" rid="T4">Table 4</xref>).</p><p>With the maxillae, however, no statistically significant difference was found between the test group and the control group for all different periods (<xref ref-type="table" rid="T5">Table 5</xref>). During the observation of the test group and the control group one year later, the survival rate and success rate were found to be 100%.</p></sec><sec sec-type="discussion"><title>DISCUSSION</title><p>The surface of root-type implant has shifted from a smooth and glossy surface to a rough one. There are several ways to form a rough surface. The hydroxyapatite process method has drawn attention for its bio-affinity and attainment of early stability. Hydroxyapatite itself is superior in terms of adhesion with bone and stabillity; in the long run, however, it is exfoliated from implant fixtures. This causes the separation of fixtures from the bone-hydroxyapatite attachment, thereby resulting in the failure of implant treatment.<xref ref-type="bibr" rid="B12">12</xref></p><p>Because this study is clinical test, roughened surface fixture was used instead of machined surface fixture. The RBM process is method to roughen the surface of the implant. CMP coating process makes just a little change of Roughness.</p><p>The CMP coating is known for its many merits compared to the plasma-sprayed hydroxyapatite (HA) coating. Its coated layer is less than 3 µm thick; unlike the hydroxyapatite coating wherein molecular exfoliation occurs due to TCP dissolution, the CMP coating does not have the same problem of exfoliation of the coated layer from implant fixtures. As an improved method of HA coating, which exfoliates from fixtures, the RBM surface is widely used for implant surface processing. According to recent animal testing, the bone-implant contact of CMP-coated fixtures had greater value than machined fixtures. Such difference was statistically significant.<xref ref-type="bibr" rid="B12">12</xref> This test did not use two different types of implants per person. As such, the comparison was not considered precise. Note, however, that no statistically significant difference was found compared to the currently commercially available RBM-processed fixtures. Therefore, the short-term use of CMP coating is clinically acceptable. Note, however, that this study did not have more frequent routine checkups within 2-3 months since the difference between RBM-processed fixtures and CMP-coated ones appears within 2-3 months of placement as reported through some studies and animal tests.<xref ref-type="bibr" rid="B28">28</xref> Thus, this is something that can be improved in the future. The measurement of mobility using Perio-test, which was also used by this study was introduced by Schulte.<xref ref-type="bibr" rid="B28">28</xref> The Perio-test is a device that figuratively displays the contact time measured through the repetition of instant contact with a measurement stick and an abutment. The Perio-test value ranges from -8 up to +50; its measurement method is simple, and it has been widely used in measuring the osseointegration of implants. Lately, the resonance frequency analysis (RFA) method has been used. Note, however, that measuring stability after prosthetic mounting requires the removal of the prosthesis, which is inconvenient. Although some studies found that the measured values of the Perio-test depended on the measuring direction and angle,<xref ref-type="bibr" rid="B29">29</xref> repetitive measurements enabled obtaining stable values; even after prosthetic mounting, the test was regarded as an appropriate method to evaluate implant stability. This study obtained acceptable Perio-test values from both the control group and the test group. No statistically significant difference was found, however. In terms of the absorption of marginal bone, both the test and control groups yielded a clinically acceptable range of values. No statistically significant difference was observed between the two groups. Although the difference was not statistically significant, the test group showed more absorption. This was believed to be due to the varying individual implants contained in the groups. In the control group, female marginal bone accounted for 50%, which was greater compared to the test group. Wyatt and Zarb<xref ref-type="bibr" rid="B30">30</xref> found during their observations one year after the implant load that the absorption level of male marginal bone was greater than the female one. Implant placement was considered successful when the cervical bone resorption measured for each implant did not exceed 1 mm for the first year.<xref ref-type="bibr" rid="B31">31</xref> This study obtained acceptable marginal bone loss from both the control group and the test group.</p><p>In the one year study after the implant placement, no clinical difference was observed between RBM-processed and CMP-coated implants. A short-term, non-destructive clinical observation method is necessary to examine the changes that occur in the early stage. Although this study was not a long-term one, a decent clinical result on CMP-coated implants was obtained. Furthermore, since CMP-coated fixtures histologically had better bone reaction than RBM-processed ones in some tests and studies, a long-term study is expected to offer a better result and require an improved evaluation method.</p></sec><sec sec-type="conclusions"><title>CONCLUSION</title><p>The result of the evaluation performed in one year after the placement of CMP-coated fixtures showed that they were comparable to conventional RBM-processed fixtures. A non-destructive clinical observation method that will examine the early changes should be developed. 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position="float"><label>Fig. 1</label><caption><p>Measurement of periotest value with periotest.</p></caption><graphic xlink:href="jap-5-172-g001"></graphic></fig><fig id="F2" orientation="portrait" position="float"><label>Fig. 2</label><caption><p>Radiograph for measurement of marginal bone resorption.</p></caption><graphic xlink:href="jap-5-172-g002"></graphic></fig><table-wrap id="T1" orientation="portrait" position="float"><label>Table 1</label><caption><p>Schedule of clinical progress</p></caption><graphic xlink:href="jap-5-172-i001"></graphic><table-wrap-foot><fn><p>"Visit 8'" is additional check-up of low jaw so that check at intervals of 3 months after setting of prosthesis.</p><p>At "Check", periapical radiograph was taken and perio-test value was measured.</p></fn></table-wrap-foot></table-wrap><table-wrap id="T2" orientation="portrait" position="float"><label>Table 2</label><caption><p>Mean and standard deviation and statistical analysis of Perio-test value one year after fixture installation</p></caption><graphic xlink:href="jap-5-172-i002"></graphic></table-wrap><table-wrap id="T3" orientation="portrait" position="float"><label>Table 3</label><caption><p>Mean and standard deviation and statistical analysis of marginal bone loss at different check point of time</p></caption><graphic xlink:href="jap-5-172-i003"></graphic></table-wrap><table-wrap id="T4" orientation="portrait" position="float"><label>Table 4</label><caption><p>Mean and standard deviation and statistical analysis of marginal bone loss between check point of time (Lower jaw)</p></caption><graphic xlink:href="jap-5-172-i004"></graphic></table-wrap><table-wrap id="T5" orientation="portrait" position="float"><label>Table 5</label><caption><p>Mean and standard deviation and statistical analysis of marginal bone loss between check point of time (Upper jaw)</p></caption><graphic xlink:href="jap-5-172-i005"></graphic></table-wrap></floats-group></pmc></record>Pour manipuler ce document sous Unix 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