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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Reactive Hyperplastic Lesions of the Oral Cavity</title><author><name sortKey="Kadeh, Hamideh" sort="Kadeh, Hamideh" uniqKey="Kadeh H" first="Hamideh" last="Kadeh">Hamideh Kadeh</name><affiliation><nlm:aff id="aff1"><italic>Dental Research Center, School of Dentistry, Zahedan University of Medical Sciences, Zahedan, Iran.</italic></nlm:aff></affiliation></author><author><name sortKey="Saravani, Shirin" sort="Saravani, Shirin" uniqKey="Saravani S" first="Shirin" last="Saravani">Shirin Saravani</name><affiliation><nlm:aff id="aff1"><italic>Dental Research Center, School of Dentistry, Zahedan University of Medical Sciences, Zahedan, Iran.</italic></nlm:aff></affiliation></author><author><name sortKey="Tajik, Mohammad" sort="Tajik, Mohammad" uniqKey="Tajik M" first="Mohammad" last="Tajik">Mohammad Tajik</name><affiliation><nlm:aff id="aff2"><bold>School of Dentistry, Zahedan University of Medical Sciences, Zahedan, Iran.</bold></nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">25938085</idno><idno type="pmc">4409958</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4409958</idno><idno type="RBID">PMC:4409958</idno><date when="2015">2015</date><idno type="wicri:Area/Pmc/Corpus">002E62</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002E62</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Reactive Hyperplastic Lesions of the Oral Cavity</title><author><name sortKey="Kadeh, Hamideh" sort="Kadeh, Hamideh" uniqKey="Kadeh H" first="Hamideh" last="Kadeh">Hamideh Kadeh</name><affiliation><nlm:aff id="aff1"><italic>Dental Research Center, School of Dentistry, Zahedan University of Medical Sciences, Zahedan, Iran.</italic></nlm:aff></affiliation></author><author><name sortKey="Saravani, Shirin" sort="Saravani, Shirin" uniqKey="Saravani S" first="Shirin" last="Saravani">Shirin Saravani</name><affiliation><nlm:aff id="aff1"><italic>Dental Research Center, School of Dentistry, Zahedan University of Medical Sciences, Zahedan, Iran.</italic></nlm:aff></affiliation></author><author><name sortKey="Tajik, Mohammad" sort="Tajik, Mohammad" uniqKey="Tajik M" first="Mohammad" last="Tajik">Mohammad Tajik</name><affiliation><nlm:aff id="aff2"><bold>School of Dentistry, Zahedan University of Medical Sciences, Zahedan, Iran.</bold></nlm:aff></affiliation></author></analytic><series><title level="j">Iranian Journal of Otorhinolaryngology</title><idno type="ISSN">2251-7251</idno><idno type="eISSN">2251-726X</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Introduction:</title><p>Peripheral reactive lesions of soft tissue are common oral lesions that dentists face during routine examinations. Diagnosis and development of a treatment plan is difficult if dentists are not aware of the prevalence and clinical symptoms of these lesions. The frequency of these lesions differs across various populations. The aim of this study was to determine the frequency and distribution of oral reactive lesions over a period of 7 years (2006–2012).</p></sec><sec><title>Materials and Methods:</title><p>In this retrospective study, available records from the archives of the Department of Pathology, Dental School and the two main hospitals in southeast of Iran (Zahedan) over a period of 7 years (2006–2012) were reviewed. Information relating to the type of reactive lesion, age, gender and location was extracted and recorded on data forms. Data were analyzed using SPSS statistical software (V.18) using the chi-square and Fisher’s exact test.</p></sec><sec><title>Results:</title><p>Of 451 oral lesions, 91 cases (20.2%) were reactive hyperplastic lesions. The most common lesions were pyogenic granuloma and irritation fibroma, respectively. These lesions were more frequent in women (60%) than men (40%). The most common locations of involvement were the gingiva and alveolar mucosa of the mandible, and lesions were more common in the 21–40-year age group. The relationship between age group and reactive lesions was statistically significant (P=0.01).</p></sec><sec><title>Conclusion: </title><p>The major findings in this study are broadly similar to the results of previous studies, with differences observed in some cases. However, knowledge of the frequency and distribution of these lesions is beneficial when establishing a diagnosis and treatment plan in clinical practice.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Effiom, Oa" uniqKey="Effiom O">OA Effiom</name></author><author><name sortKey="Adeyemo, Wl" uniqKey="Adeyemo W">WL Adeyemo</name></author><author><name sortKey="Soyele, Oo" uniqKey="Soyele O">OO Soyele</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jalayer, Naderi N" uniqKey="Jalayer N">Naderi N Jalayer</name></author><author><name sortKey="Eshghyar, N" uniqKey="Eshghyar N">N Eshghyar</name></author><author><name sortKey="Esfehanian, H" uniqKey="Esfehanian H">H Esfehanian</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Reddy, V" uniqKey="Reddy V">V Reddy</name></author><author><name sortKey="Saxena, S" uniqKey="Saxena S">S 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<front><journal-meta><journal-id journal-id-type="nlm-ta">Iran J Otorhinolaryngol</journal-id><journal-id journal-id-type="iso-abbrev">Iran J Otorhinolaryngol</journal-id><journal-id journal-id-type="publisher-id">IJO</journal-id><journal-title-group><journal-title>Iranian Journal of Otorhinolaryngology</journal-title></journal-title-group><issn pub-type="ppub">2251-7251</issn><issn pub-type="epub">2251-726X</issn><publisher><publisher-name>Mashhad University of Medical Sciences</publisher-name><publisher-loc>Mashhad, Iran</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">25938085</article-id><article-id pub-id-type="pmc">4409958</article-id><article-id pub-id-type="publisher-id">ijo-27-137</article-id><article-categories><subj-group subj-group-type="heading"><subject>Original Article</subject></subj-group></article-categories><title-group><article-title>Reactive Hyperplastic Lesions of the Oral Cavity</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Kadeh</surname><given-names>Hamideh</given-names></name><xref ref-type="aff" rid="aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Saravani</surname><given-names>Shirin</given-names></name><xref ref-type="corresp" rid="cor1">*</xref><xref ref-type="aff" rid="aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Tajik</surname><given-names>Mohammad</given-names></name><xref ref-type="aff" rid="aff2">2</xref></contrib></contrib-group><aff id="aff1"><label>1</label><italic>Dental Research Center, School of Dentistry, Zahedan University of Medical Sciences, Zahedan, Iran.</italic></aff><aff id="aff2"><label>2</label><bold>School of Dentistry, Zahedan University of Medical Sciences, Zahedan, Iran.</bold></aff><author-notes><corresp id="cor1"><label>*</label>Corresponding Author: Department of Oral and Maxillofacial Pathology, School of Dentistry, Zahedan University of Medical Sciences, Zahedan, Iran. Tel: 00985433414001, E-mail: Shirin.Saravani@yahoo.com</corresp></author-notes><pub-date pub-type="ppub"><month>3</month><year>2015</year></pub-date><volume>27</volume><issue>79</issue><fpage>137</fpage><lpage>144</lpage><history><date date-type="received"><day>18</day><month>2</month><year>2014</year></date><date date-type="accepted"><day>14</day><month>7</month><year>2014</year></date></history><permissions><license><license-p>This is an Open Access article distributed under the terms of the Creative Commons Attribution License, (<ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by/3.0/">http://creativecommons.org/licenses/by/3.0/</ext-link>) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</license-p></license></permissions><abstract><sec><title>Introduction:</title><p>Peripheral reactive lesions of soft tissue are common oral lesions that dentists face during routine examinations. Diagnosis and development of a treatment plan is difficult if dentists are not aware of the prevalence and clinical symptoms of these lesions. The frequency of these lesions differs across various populations. The aim of this study was to determine the frequency and distribution of oral reactive lesions over a period of 7 years (2006–2012).</p></sec><sec><title>Materials and Methods:</title><p>In this retrospective study, available records from the archives of the Department of Pathology, Dental School and the two main hospitals in southeast of Iran (Zahedan) over a period of 7 years (2006–2012) were reviewed. Information relating to the type of reactive lesion, age, gender and location was extracted and recorded on data forms. Data were analyzed using SPSS statistical software (V.18) using the chi-square and Fisher’s exact test.</p></sec><sec><title>Results:</title><p>Of 451 oral lesions, 91 cases (20.2%) were reactive hyperplastic lesions. The most common lesions were pyogenic granuloma and irritation fibroma, respectively. These lesions were more frequent in women (60%) than men (40%). The most common locations of involvement were the gingiva and alveolar mucosa of the mandible, and lesions were more common in the 21–40-year age group. The relationship between age group and reactive lesions was statistically significant (P=0.01).</p></sec><sec><title>Conclusion: </title><p>The major findings in this study are broadly similar to the results of previous studies, with differences observed in some cases. However, knowledge of the frequency and distribution of these lesions is beneficial when establishing a diagnosis and treatment plan in clinical practice.</p></sec></abstract><kwd-group><title>Key Words</title><kwd>Fibroma</kwd><kwd>Oral cavity</kwd><kwd>Pyogenic granuloma</kwd><kwd>Soft tissue</kwd></kwd-group></article-meta></front><body><sec sec-type="intro"><title>Introduction</title><p>Because the oral mucosa is constantly under the influence of various internal and external stimuli, it exhibits a range of developmental disorders, irritation, inflammation, and neoplastic conditions (<xref rid="B1" ref-type="bibr">1</xref>). Reactive lesions are tumor-like hyperplasias which show a response to a low-grade irritation or injury (<xref rid="B2" ref-type="bibr">2</xref>), such as chewing, food impaction, calculus, iatrogenic injuries such as broken teeth, overhanging dental restorations and extended flanges of denture (<xref rid="B3" ref-type="bibr">3</xref>). Irritation fibroma, pyogenic granuloma, peripheral giant cell granuloma, and cemento-ossifying fibroma are common oral cavity reactive lesions. Other reactive lesions of the oral cavity include epulis fissuratum, inflammatory papillary hyperplasia and inflammatory fibrous hyperplasia (<xref rid="B2" ref-type="bibr">2</xref>). Reactive lesions are commonly seen in the gingiva and their occurrence in other places of the oral cavity, such as the tongue, palate, cheek and floor of the mouth is less common (<xref rid="B1" ref-type="bibr">1</xref>). Clinical features of these lesions consist of sessile or pedunculated masses with smooth or injured surfaces, and are seen in different colors, from bright pink to red (<xref rid="B4" ref-type="bibr">4</xref>). Since it is possible to detect lesions with a specific nature based on their histopathological features, these lesions can be divided into vascular and fibrous types (<xref rid="B5" ref-type="bibr">5</xref>). Various studies have reported differences in the type of reactive lesions, age distribution, gender, location, and clinical behavior of these lesions in different populations (<xref rid="B2" ref-type="bibr">2</xref>). The clinical appearance of these lesions is similar to neoplastic lesions. This similarity is a challenge in the process of diagnosis (<xref rid="B2" ref-type="bibr">2</xref>). Furthermore, early detection and treatment of reactive lesions by dentists can reduce dentoalveolar complications. Therefore awareness of the frequency and description of such lesions can help clinicians to make a better diagnosis and offer optimal treatment (<xref rid="B6" ref-type="bibr">6</xref>). Studies of the frequency of oral cavity reactive lesions have not previously been conducted in Southeast Iran. The aim of this retrospective study was to determine the relative prevalence and distribution of the oral cavity reactive lesions referred to the Department of Oral Pathology and two hospitals in Zahedan (Southeast of Iran) during a 7-year period and to compare the results with those of similar studies.</p></sec><sec sec-type="materials|methods"><title>Materials and Methods</title><p>In this retrospective study, records in the Department of Oral Pathology, Dental School, Zahedan University of Medical Sciences and Khatam-Alanbia and TaminEjtemaei Hospitals were extracted between 2006 and 2012. Records with a histopathological diagnosis of reactive hyperplasic lesions of the oral cavity were selected. These lesions were classified into two groups: fibrous lesions with connective tissue predominantly consisting of collagen (epulis fissuratum, irritation fibroma, giant cell fibroma, peripheral ossifying fibroma) and soft hemorrhagic lesions that are highly vascular, in which hemorrhage is an important clinical and histological feature (pyogenic granuloma, peripheral giant cell granuloma, epulis granulomatosum and pregnancy tumor) (<xref rid="B5" ref-type="bibr">5</xref>).</p><p>The only exclusion criterion was incompletely registered records. Clinical data regarding age, gender, and the anatomical location of the lesions were collected for each case. Data were analyzed using SPSS software version 18.0 (SPSS Inc, Chicago, IL) using descriptive statistical methods (means, standard deviations and percentages), chi-square and Fisher’s exact test. P-values less than 0.05 were considered statistically significant.</p></sec><sec sec-type="results"><title>Results</title><p>Of a total of 451 lesions recorded in the biopsy records during the period assessed, 91(20.2%) were reactive hyperplasia; 35(38%) were fibrous lesions and 56 (62%) were soft hemorrhagic lesions. The most common lesion was pyogenic granuloma (n=37, 41%) followed by 18 cases (20%) of irritation fibroma, 15 cases (16.5%) of peripheral giant cell granuloma, 11 cases (12%) of peripheral ossifying fibroma, and the least common lesion was inflammatory papillary hyperplasia (n=1, 1%). The most prevalent reactive hemorrhagic and fibrous lesions were pyogenic granuloma and irritation fibroma, respectively (<xref ref-type="fig" rid="F1">Fig. 1</xref>).</p><fig id="F1" position="float"><label>Fig 1</label><caption><p>Distribution of oral cavity reactive lesions</p></caption><graphic xlink:href="ijo-27-137-g001"></graphic><p>PG: Pyogenic granuloma, IF: Irritiation fibroma, PGCG: Peripheral giant cell granuloma, POF: Peripheral ossifying fibroma, GCF: Giant cell fibroma, EG: Epulis granulomatosum, PT: Pregnancy tumor, EF: Epulis fissuratum, IPH: Inflammatory papillary hyperplasia</p></fig><p>The mean age of the patients in this study was 33.95±17.75 years (range, 4–88 years). The mean age of patients with irritation fibroma (IF), pyogenic granuloma (PG), peripheral ossifying fibroma (POF) and peripheral giant cell granuloma (PGCG) were 42.5±23.4, 30.4±14.9, 41.3±15.1 and 25.6±16.2 years, respectively. The lesions were most commonly seen in the third and fourth decades of life and less commonly seen above the age of 60 years. </p><p>Fibrous lesions were more common in the fifth and sixth decades and soft hemorrhagic lesions were more common in the third and fourth decades of life. </p><p>The distribution of fibrous and hemorrhagic lesions in relation to age group is shown in <xref ref-type="table" rid="T1">Tables 1</xref> and <xref ref-type="table" rid="T2">2</xref>. The relationship between age group and fibrous/ hemorrhagic lesions was statistically significant (P=0.012).</p><table-wrap id="T1" position="float"><label>Table 1</label><caption><p>Distribution of fibrous lesions by age group</p></caption><table frame="hsides" rules="groups"><thead><tr><th style="background-color:#D9D9D9;" align="left" valign="middle" rowspan="1" colspan="1"><bold>Lesion</bold></th><th style="background-color:#D9D9D9;" align="center" valign="middle" rowspan="1" colspan="1"><bold>IF</bold></th><th style="background-color:#D9D9D9;" align="center" valign="middle" rowspan="1" colspan="1"><bold>POF</bold></th><th style="background-color:#D9D9D9;" align="center" valign="middle" rowspan="1" colspan="1"><bold>GCF</bold></th><th style="background-color:#D9D9D9;" align="center" valign="middle" rowspan="1" colspan="1"><bold>EF</bold></th><th style="background-color:#D9D9D9;" align="center" valign="middle" rowspan="1" colspan="1"><bold>IPH</bold></th><th style="background-color:#D9D9D9;" align="center" valign="middle" rowspan="1" colspan="1"><bold>Total</bold></th></tr></thead><tbody><tr><td style="background-color:#D9D9D9;" align="right" valign="middle" rowspan="1" colspan="1">Age group</td><td align="center" valign="middle" rowspan="1" colspan="1">No. (%)</td><td align="center" valign="middle" rowspan="1" colspan="1">No. (%)</td><td align="center" valign="middle" rowspan="1" colspan="1">No. (%)</td><td align="center" valign="middle" rowspan="1" colspan="1">No. (%)</td><td align="center" valign="middle" rowspan="1" colspan="1">No. (%)</td><td align="center" valign="middle" rowspan="1" colspan="1">No. (%)</td></tr><tr><td style="background-color:#D9D9D9;" align="left" valign="bottom" rowspan="1" colspan="1">≤20</td><td align="center" valign="middle" rowspan="1" colspan="1">4 (4.5)</td><td align="center" valign="middle" rowspan="1" colspan="1">2 (2)</td><td align="center" valign="middle" rowspan="1" colspan="1">0</td><td align="center" valign="middle" rowspan="1" colspan="1">1 (1)</td><td align="center" valign="middle" rowspan="1" colspan="1">0</td><td align="center" valign="middle" rowspan="1" colspan="1">7 (7.5)</td></tr><tr><td style="background-color:#D9D9D9;" align="left" valign="bottom" rowspan="1" colspan="1">21–40</td><td align="center" valign="middle" rowspan="1" colspan="1">4 (4.5)</td><td align="center" valign="middle" rowspan="1" colspan="1">3 (3.5)</td><td align="center" valign="middle" rowspan="1" colspan="1">1 (1)</td><td align="center" valign="middle" rowspan="1" colspan="1">0</td><td align="center" valign="middle" rowspan="1" colspan="1">0</td><td align="center" valign="middle" rowspan="1" colspan="1">8 (9)</td></tr><tr><td style="background-color:#D9D9D9;" align="left" valign="bottom" rowspan="1" colspan="1">41–60</td><td align="center" valign="middle" rowspan="1" colspan="1">6 (6.5)</td><td align="center" valign="middle" rowspan="1" colspan="1">4 (4.5)</td><td align="center" valign="middle" rowspan="1" colspan="1">2 (2)</td><td align="center" valign="middle" rowspan="1" colspan="1">1 (1)</td><td align="center" valign="middle" rowspan="1" colspan="1">1 (1)</td><td align="center" valign="middle" rowspan="1" colspan="1">14 (15)</td></tr><tr><td style="background-color:#D9D9D9;" align="left" valign="bottom" rowspan="1" colspan="1">≥61</td><td align="center" valign="middle" rowspan="1" colspan="1">4 (4.5)</td><td align="center" valign="middle" rowspan="1" colspan="1">2 (2)</td><td align="center" valign="middle" rowspan="1" colspan="1">0</td><td align="center" valign="middle" rowspan="1" colspan="1">0</td><td align="center" valign="middle" rowspan="1" colspan="1">0</td><td align="center" valign="middle" rowspan="1" colspan="1">6 (6.5)</td></tr><tr><td style="background-color:#D9D9D9;" align="left" valign="bottom" rowspan="1" colspan="1">Total</td><td align="center" valign="middle" rowspan="1" colspan="1">18 (20)</td><td align="center" valign="middle" rowspan="1" colspan="1">11 (12)</td><td align="center" valign="middle" rowspan="1" colspan="1">3 (3)</td><td align="center" valign="middle" rowspan="1" colspan="1">2 (2)</td><td align="center" valign="middle" rowspan="1" colspan="1">1 (1)</td><td align="center" valign="middle" rowspan="1" colspan="1">35 (38)</td></tr></tbody></table><table-wrap-foot><p>IF: Irritation fibroma, POF: Peripheral ossifying fibroma, GCF: Giant cell fibroma, EF: Epulis fissuratum, IPH: Inflammatory papillary hyperplasia</p></table-wrap-foot></table-wrap><table-wrap id="T2" position="float"><label>Table 2</label><caption><p>Distribution of soft hemorrhagic lesions by age group</p></caption><table frame="hsides" rules="groups"><thead><tr><th style="background-color:#D9D9D9;" align="left" valign="middle" rowspan="1" colspan="1"><bold>Lesion</bold></th><th style="background-color:#D9D9D9;" align="center" valign="middle" rowspan="1" colspan="1"><bold>PG</bold></th><th style="background-color:#D9D9D9;" align="center" valign="middle" rowspan="1" colspan="1"><bold>PGCG</bold></th><th style="background-color:#D9D9D9;" align="center" valign="middle" rowspan="1" colspan="1"><bold>PT</bold></th><th style="background-color:#D9D9D9;" align="center" valign="middle" rowspan="1" colspan="1"><bold>EG</bold></th><th style="background-color:#D9D9D9;" align="center" valign="middle" rowspan="1" colspan="1"><bold>Total</bold></th></tr></thead><tbody><tr><td style="background-color:#D9D9D9;" align="left" valign="middle" rowspan="1" colspan="1">Age group</td><td align="center" valign="middle" rowspan="1" colspan="1">No. (%)</td><td align="center" valign="middle" rowspan="1" colspan="1">No .(%)</td><td align="center" valign="middle" rowspan="1" colspan="1">No. (%)</td><td align="center" valign="middle" rowspan="1" colspan="1">No. (%)</td><td align="center" valign="middle" rowspan="1" colspan="1">No. (%)</td></tr><tr><td style="background-color:#D9D9D9;" align="left" valign="middle" rowspan="1" colspan="1">≤20</td><td align="center" valign="middle" rowspan="1" colspan="1">11 (12)</td><td align="center" valign="middle" rowspan="1" colspan="1">7 (7.5)</td><td align="center" valign="middle" rowspan="1" colspan="1">0</td><td align="center" valign="middle" rowspan="1" colspan="1">0</td><td align="center" valign="middle" rowspan="1" colspan="1">18 (19.5)</td></tr><tr><td style="background-color:#D9D9D9;" align="left" valign="middle" rowspan="1" colspan="1">21–40</td><td align="center" valign="middle" rowspan="1" colspan="1">15 (16.5)</td><td align="center" valign="middle" rowspan="1" colspan="1">5 (5.5)</td><td align="center" valign="middle" rowspan="1" colspan="1">2 (2)</td><td align="center" valign="middle" rowspan="1" colspan="1">2 (2)</td><td align="center" valign="middle" rowspan="1" colspan="1">24 (26)</td></tr><tr><td style="background-color:#D9D9D9;" align="left" valign="middle" rowspan="1" colspan="1">41–60</td><td align="center" valign="middle" rowspan="1" colspan="1">10 (11.5)</td><td align="center" valign="middle" rowspan="1" colspan="1">3 (3)</td><td align="center" valign="middle" rowspan="1" colspan="1">0</td><td align="center" valign="middle" rowspan="1" colspan="1">0</td><td align="center" valign="middle" rowspan="1" colspan="1">13 (14.5)</td></tr><tr><td style="background-color:#D9D9D9;" align="left" valign="middle" rowspan="1" colspan="1">≥61</td><td align="center" valign="middle" rowspan="1" colspan="1">1 (1)</td><td align="center" valign="middle" rowspan="1" colspan="1">0</td><td align="center" valign="middle" rowspan="1" colspan="1">0</td><td align="center" valign="middle" rowspan="1" colspan="1">0</td><td align="center" valign="middle" rowspan="1" colspan="1">1 (1)</td></tr><tr><td style="background-color:#D9D9D9;" align="left" valign="middle" rowspan="1" colspan="1">Total</td><td align="center" valign="middle" rowspan="1" colspan="1">37 (41)</td><td align="center" valign="middle" rowspan="1" colspan="1">15 (16.5)</td><td align="center" valign="middle" rowspan="1" colspan="1">2 (2)</td><td align="center" valign="middle" rowspan="1" colspan="1">2 (2)</td><td align="center" valign="middle" rowspan="1" colspan="1">56 (61)</td></tr></tbody></table><table-wrap-foot><p>PG: Pyogenic granuloma, PGCG: Peripheral giant cell granuloma, PT: Pregnancy tumor, EG: Epulis granulomatosum</p></table-wrap-foot></table-wrap><p>Of all the patients examined, 36 (40%) were male, 55 (60%) were female, with a female: male ratio of 1:1.4. In PG, POF and PGCG, females were more commonly affected than males, but in IF more males were affected. The distribution of fibrous and hemorrhagic lesions in relation to gender is shown in <xref ref-type="table" rid="T3">Tables 3</xref> and <xref ref-type="table" rid="T4">4</xref>. The relationship between gender and fibrous/hemorrhagic lesions was not statistically significant (P=0.32).</p><table-wrap id="T3" position="float"><label>Table 3</label><caption><p>Distribution of fibrous lesions by gender</p></caption><table frame="hsides" rules="groups"><thead><tr><th style="background-color:#D9D9D9;" align="left" valign="middle" rowspan="1" colspan="1"><bold>Lesion</bold></th><th style="background-color:#D9D9D9;" align="center" valign="middle" rowspan="1" colspan="1"><bold>IF</bold></th><th style="background-color:#D9D9D9;" align="center" valign="middle" rowspan="1" colspan="1"><bold>POF</bold></th><th style="background-color:#D9D9D9;" align="center" valign="middle" rowspan="1" colspan="1"><bold>GCF</bold></th><th style="background-color:#D9D9D9;" align="center" valign="middle" rowspan="1" colspan="1"><bold>EF</bold></th><th style="background-color:#D9D9D9;" align="center" valign="middle" rowspan="1" colspan="1"><bold>IPH</bold></th><th style="background-color:#D9D9D9;" align="center" valign="middle" rowspan="1" colspan="1"><bold>Total</bold></th></tr></thead><tbody><tr><td style="background-color:#D9D9D9;" align="left" valign="middle" rowspan="1" colspan="1">Gender</td><td align="center" valign="middle" rowspan="1" colspan="1">No. (%)</td><td align="center" valign="middle" rowspan="1" colspan="1">No. (%)</td><td align="center" valign="middle" rowspan="1" colspan="1">No. (%)</td><td align="center" valign="middle" rowspan="1" colspan="1">No. (%)</td><td align="center" valign="middle" rowspan="1" colspan="1">No. (%)</td><td align="center" valign="middle" rowspan="1" colspan="1">No. (%)</td></tr><tr><td style="background-color:#D9D9D9;" align="left" valign="middle" rowspan="1" colspan="1">Male</td><td align="center" valign="bottom" rowspan="1" colspan="1">10 (11.5)</td><td align="center" valign="middle" rowspan="1" colspan="1">2 (2)</td><td align="center" valign="middle" rowspan="1" colspan="1">1 (1)</td><td align="center" valign="middle" rowspan="1" colspan="1">1 (1)</td><td align="center" valign="middle" rowspan="1" colspan="1">1 (1)</td><td align="center" valign="middle" rowspan="1" colspan="1">15 (16.5)</td></tr><tr><td style="background-color:#D9D9D9;" align="left" valign="middle" rowspan="1" colspan="1">Female</td><td align="center" valign="middle" rowspan="1" colspan="1">8 (8.5)</td><td align="center" valign="middle" rowspan="1" colspan="1">9 (10)</td><td align="center" valign="middle" rowspan="1" colspan="1">2 (2)</td><td align="center" valign="middle" rowspan="1" colspan="1">1 (1)</td><td align="center" valign="middle" rowspan="1" colspan="1">0</td><td align="center" valign="middle" rowspan="1" colspan="1">20 (21.5)</td></tr><tr><td style="background-color:#D9D9D9;" align="left" valign="middle" rowspan="1" colspan="1">Total</td><td align="center" valign="middle" rowspan="1" colspan="1">18 (20)</td><td align="center" valign="middle" rowspan="1" colspan="1">11 (12)</td><td align="center" valign="middle" rowspan="1" colspan="1">3 (3)</td><td align="center" valign="middle" rowspan="1" colspan="1">2 (2)</td><td align="center" valign="middle" rowspan="1" colspan="1">1 (1)</td><td align="center" valign="middle" rowspan="1" colspan="1">35 (38)</td></tr></tbody></table><table-wrap-foot><p>IF: Irritation fibroma, POF: Peripheral ossifying fibroma, GCF: Giant cell fibroma, EF: Epulis fissuratum, IPH: Inflammatory papillary hyperplasia</p></table-wrap-foot></table-wrap><table-wrap id="T4" position="float"><label>Table 4</label><caption><p>Distribution of soft hemorrhagic lesions by gender</p></caption><table frame="hsides" rules="groups"><thead><tr><th style="background-color:#D9D9D9;" align="center" valign="middle" rowspan="1" colspan="1"><bold>Lesions</bold></th><th style="background-color:#D9D9D9;" align="center" valign="middle" rowspan="1" colspan="1"><bold>PG</bold></th><th style="background-color:#D9D9D9;" align="center" valign="middle" rowspan="1" colspan="1"><bold>PGCG</bold></th><th style="background-color:#D9D9D9;" align="center" valign="middle" rowspan="1" colspan="1"><bold>PT</bold></th><th style="background-color:#D9D9D9;" align="center" valign="middle" rowspan="1" colspan="1"><bold>EG</bold></th><th style="background-color:#D9D9D9;" align="center" valign="middle" rowspan="1" colspan="1"><bold>Total</bold></th></tr></thead><tbody><tr><td style="background-color:#D9D9D9;" align="center" valign="middle" rowspan="1" colspan="1">Gender</td><td align="center" valign="middle" rowspan="1" colspan="1">No. (%)</td><td align="center" valign="middle" rowspan="1" colspan="1">No. (%)</td><td align="center" valign="middle" rowspan="1" colspan="1">No. (%)</td><td align="center" valign="middle" rowspan="1" colspan="1">No. (%)</td><td align="center" valign="middle" rowspan="1" colspan="1">No. (%)</td></tr><tr><td style="background-color:#D9D9D9;" align="center" valign="middle" rowspan="1" colspan="1">Male</td><td align="center" valign="middle" rowspan="1" colspan="1">15 (16.5)</td><td align="center" valign="middle" rowspan="1" colspan="1">5 (5.5)</td><td align="center" valign="middle" rowspan="1" colspan="1">0</td><td align="center" valign="middle" rowspan="1" colspan="1">1 (1)</td><td align="center" valign="middle" rowspan="1" colspan="1">21 (23)</td></tr><tr><td style="background-color:#D9D9D9;" align="center" valign="middle" rowspan="1" colspan="1">Female</td><td align="center" valign="middle" rowspan="1" colspan="1">22 (24.5)</td><td align="center" valign="middle" rowspan="1" colspan="1">10 (11)</td><td align="center" valign="middle" rowspan="1" colspan="1">2 (2)</td><td align="center" valign="middle" rowspan="1" colspan="1">1 (1)</td><td align="center" valign="middle" rowspan="1" colspan="1">35 (38.5)</td></tr><tr><td style="background-color:#D9D9D9;" align="center" valign="middle" rowspan="1" colspan="1">Total</td><td align="center" valign="middle" rowspan="1" colspan="1">37 (41)</td><td align="center" valign="middle" rowspan="1" colspan="1">15 (16.5)</td><td align="center" valign="middle" rowspan="1" colspan="1">2 (2)</td><td align="center" valign="middle" rowspan="1" colspan="1">2 (2)</td><td align="center" valign="middle" rowspan="1" colspan="1">56 (61.5)</td></tr></tbody></table><table-wrap-foot><p>PG: Pyogenic granuloma, PGCG: Peripheral giant cell granuloma, PT: Pregnancy tumor, EG: Epulis granulomatosum</p></table-wrap-foot></table-wrap><p>With 27 cases, gingiva of the lower jaw was the most common site, followed by gingiva of the upper jaw (23 cases), lip (15 cases), buccal mucosa (12 cases), and tongue (three cases). Gingiva of the upper jaw was the most common site for fibrous lesions, and these lesions were not found in tongue area. Gingiva of the lower jaw was the most common site for hemorrhagic lesions, and these lesions were not found in palate area. In IF and PG, the most common sites affected were the buccal mucosa and gingiva, respectively, but POF and PGCG were limited to the gingiva. The distribution of fibrous and hemorrhagic lesions according to location is shown in <xref ref-type="table" rid="T5">Tables 5</xref> and <xref ref-type="table" rid="T6">6</xref>.</p><table-wrap id="T5" position="float"><label>Table 5</label><caption><p>Distribution fibrous lesions by location</p></caption><table frame="hsides" rules="groups"><thead><tr><th style="background-color:#D9D9D9;" align="left" valign="middle" rowspan="1" colspan="1"><bold>Lesions</bold></th><th style="background-color:#D9D9D9;" align="center" valign="middle" rowspan="1" colspan="1"><bold>IF</bold></th><th style="background-color:#D9D9D9;" align="center" valign="middle" rowspan="1" colspan="1"><bold>POF</bold></th><th style="background-color:#D9D9D9;" align="center" valign="middle" rowspan="1" colspan="1"><bold>GCF</bold></th><th style="background-color:#D9D9D9;" align="center" valign="middle" rowspan="1" colspan="1"><bold>EF</bold></th><th style="background-color:#D9D9D9;" align="center" valign="middle" rowspan="1" colspan="1"><bold>IPH</bold></th><th style="background-color:#D9D9D9;" align="center" valign="middle" rowspan="1" colspan="1"><bold>Total</bold></th></tr></thead><tbody><tr><td style="background-color:#D9D9D9;" align="left" valign="middle" rowspan="1" colspan="1">location</td><td align="center" valign="middle" rowspan="1" colspan="1">No. (%)</td><td align="center" valign="middle" rowspan="1" colspan="1">No. (%)</td><td align="center" valign="middle" rowspan="1" colspan="1">No. (%)</td><td align="center" valign="middle" rowspan="1" colspan="1">No. (%)</td><td align="center" valign="middle" rowspan="1" colspan="1">No. (%)</td><td align="center" valign="middle" rowspan="1" colspan="1">No. (%)</td></tr><tr><td style="background-color:#D9D9D9;" align="left" valign="middle" rowspan="1" colspan="1">Gingiva Max</td><td align="center" valign="middle" rowspan="1" colspan="1">3 (3)</td><td align="center" valign="middle" rowspan="1" colspan="1">6 (6.5)</td><td align="center" valign="middle" rowspan="1" colspan="1">0</td><td align="center" valign="middle" rowspan="1" colspan="1">1 (1)</td><td align="center" valign="middle" rowspan="1" colspan="1">0</td><td align="center" valign="middle" rowspan="1" colspan="1">10 (10.5)</td></tr><tr><td style="background-color:#D9D9D9;" align="left" valign="middle" rowspan="1" colspan="1">Gingiva Man</td><td align="center" valign="middle" rowspan="1" colspan="1">2 (2)</td><td align="center" valign="middle" rowspan="1" colspan="1">3(3)</td><td align="center" valign="middle" rowspan="1" colspan="1">1 (1)</td><td align="center" valign="middle" rowspan="1" colspan="1">1 (1)</td><td align="center" valign="middle" rowspan="1" colspan="1">0</td><td align="center" valign="middle" rowspan="1" colspan="1">7 (7)</td></tr><tr><td style="background-color:#D9D9D9;" align="left" valign="middle" rowspan="1" colspan="1">Tongue</td><td align="center" valign="middle" rowspan="1" colspan="1">0</td><td align="center" valign="middle" rowspan="1" colspan="1">0</td><td align="center" valign="middle" rowspan="1" colspan="1">0</td><td align="center" valign="middle" rowspan="1" colspan="1">0</td><td align="center" valign="middle" rowspan="1" colspan="1">0</td><td align="center" valign="middle" rowspan="1" colspan="1">0</td></tr><tr><td style="background-color:#D9D9D9;" align="left" valign="middle" rowspan="1" colspan="1">Buccal</td><td align="center" valign="middle" rowspan="1" colspan="1">7 (8.5)</td><td align="center" valign="middle" rowspan="1" colspan="1">0</td><td align="center" valign="middle" rowspan="1" colspan="1">0</td><td align="center" valign="middle" rowspan="1" colspan="1">0</td><td align="center" valign="middle" rowspan="1" colspan="1">0</td><td align="center" valign="middle" rowspan="1" colspan="1">7 (8.5)</td></tr><tr><td style="background-color:#D9D9D9;" align="left" valign="middle" rowspan="1" colspan="1">Palate</td><td align="center" valign="middle" rowspan="1" colspan="1">3 (3)</td><td align="center" valign="middle" rowspan="1" colspan="1">0</td><td align="center" valign="middle" rowspan="1" colspan="1">0</td><td align="center" valign="middle" rowspan="1" colspan="1">0</td><td align="center" valign="middle" rowspan="1" colspan="1">1 (1)</td><td align="center" valign="middle" rowspan="1" colspan="1">4 (4)</td></tr><tr><td style="background-color:#D9D9D9;" align="left" valign="middle" rowspan="1" colspan="1">Lip</td><td align="center" valign="middle" rowspan="1" colspan="1">2 (2)</td><td align="center" valign="middle" rowspan="1" colspan="1">0</td><td align="center" valign="middle" rowspan="1" colspan="1">2 (2)</td><td align="center" valign="middle" rowspan="1" colspan="1">0</td><td align="center" valign="middle" rowspan="1" colspan="1">0</td><td align="center" valign="middle" rowspan="1" colspan="1">4 (4)</td></tr><tr><td style="background-color:#D9D9D9;" align="left" valign="middle" rowspan="1" colspan="1">Total</td><td align="center" valign="middle" rowspan="1" colspan="1">17 (18.5)<xref ref-type="table-fn" rid="TFN1">*</xref></td><td align="center" valign="middle" rowspan="1" colspan="1">9 (9.5)<xref ref-type="table-fn" rid="TFN1">*</xref></td><td align="center" valign="middle" rowspan="1" colspan="1">3 (3)</td><td align="center" valign="middle" rowspan="1" colspan="1">2 (2)</td><td align="center" valign="middle" rowspan="1" colspan="1">1 (1)</td><td align="center" valign="middle" rowspan="1" colspan="1">32 (34)</td></tr></tbody></table><table-wrap-foot><p>IF: Irritiation fibroma, POF: Peripheral ossifying fibroma, GCF: Giant cell fibroma, EF: Epulis fissuratum, IPH: Inflammatory papillary hyperplasia </p><fn id="TFN1"><label>*</label><p>Location of lesion was not recorded in the patient's record (one case of Irritation fibroma, two cases of peripheral ossifying fibroma)</p></fn></table-wrap-foot></table-wrap><table-wrap id="T6" position="float"><label>Table 6</label><caption><p>Distribution of soft hemorrhagic lesions by location</p></caption><table frame="hsides" rules="groups"><thead><tr><th style="background-color:#D9D9D9;" align="left" valign="middle" rowspan="1" colspan="1"><bold>Lesions</bold></th><th style="background-color:#D9D9D9;" align="center" valign="middle" rowspan="1" colspan="1"><bold>PG</bold></th><th style="background-color:#D9D9D9;" align="center" valign="middle" rowspan="1" colspan="1"><bold>PGCG</bold></th><th style="background-color:#D9D9D9;" align="center" valign="middle" rowspan="1" colspan="1"><bold>PT</bold></th><th style="background-color:#D9D9D9;" align="center" valign="middle" rowspan="1" colspan="1"><bold>EG</bold></th><th style="background-color:#D9D9D9;" align="center" valign="middle" rowspan="1" colspan="1"><bold>Total</bold></th></tr></thead><tbody><tr><td style="background-color:#D9D9D9;" align="left" valign="middle" rowspan="1" colspan="1">location</td><td align="center" valign="middle" rowspan="1" colspan="1">No. (%)</td><td align="center" valign="middle" rowspan="1" colspan="1">No. (%)</td><td align="center" valign="middle" rowspan="1" colspan="1">No. (%)</td><td align="center" valign="middle" rowspan="1" colspan="1">No. (%)</td><td align="center" valign="middle" rowspan="1" colspan="1">No. (%)</td></tr><tr><td style="background-color:#D9D9D9;" align="left" valign="middle" rowspan="1" colspan="1">Gingiva Max</td><td align="center" valign="middle" rowspan="1" colspan="1">6 (6.5)</td><td align="center" valign="middle" rowspan="1" colspan="1">6 (6.5)</td><td align="center" valign="middle" rowspan="1" colspan="1">0</td><td align="center" valign="middle" rowspan="1" colspan="1">1 (1)</td><td align="center" valign="middle" rowspan="1" colspan="1">13 (14)</td></tr><tr><td style="background-color:#D9D9D9;" align="left" valign="middle" rowspan="1" colspan="1">Gingiva Man</td><td align="center" valign="middle" rowspan="1" colspan="1">9 (10)</td><td align="center" valign="middle" rowspan="1" colspan="1">8 (9)</td><td align="center" valign="middle" rowspan="1" colspan="1">2 (2)</td><td align="center" valign="middle" rowspan="1" colspan="1">1 (1)</td><td align="center" valign="middle" rowspan="1" colspan="1">20 (22)</td></tr><tr><td style="background-color:#D9D9D9;" align="left" valign="middle" rowspan="1" colspan="1">tongue</td><td align="center" valign="middle" rowspan="1" colspan="1">3 (3)</td><td align="center" valign="middle" rowspan="1" colspan="1">0</td><td align="center" valign="middle" rowspan="1" colspan="1">0</td><td align="center" valign="middle" rowspan="1" colspan="1">0</td><td align="center" valign="middle" rowspan="1" colspan="1">3 (3)</td></tr><tr><td style="background-color:#D9D9D9;" align="left" valign="middle" rowspan="1" colspan="1">Buccal</td><td align="center" valign="middle" rowspan="1" colspan="1">5 (6)</td><td align="center" valign="middle" rowspan="1" colspan="1">0</td><td align="center" valign="middle" rowspan="1" colspan="1">0</td><td align="center" valign="middle" rowspan="1" colspan="1">0</td><td align="center" valign="middle" rowspan="1" colspan="1">5 (6)</td></tr><tr><td style="background-color:#D9D9D9;" align="left" valign="middle" rowspan="1" colspan="1">Palate</td><td align="center" valign="middle" rowspan="1" colspan="1">0</td><td align="center" valign="middle" rowspan="1" colspan="1">0</td><td align="center" valign="middle" rowspan="1" colspan="1">0</td><td align="center" valign="middle" rowspan="1" colspan="1">0</td><td align="center" valign="middle" rowspan="1" colspan="1">0</td></tr><tr><td style="background-color:#D9D9D9;" align="left" valign="middle" rowspan="1" colspan="1">Lip</td><td align="center" valign="middle" rowspan="1" colspan="1">11 (12)</td><td align="center" valign="middle" rowspan="1" colspan="1">0</td><td align="center" valign="middle" rowspan="1" colspan="1">0</td><td align="center" valign="middle" rowspan="1" colspan="1">0</td><td align="center" valign="middle" rowspan="1" colspan="1">11 (12)</td></tr><tr><td style="background-color:#D9D9D9;" align="left" valign="middle" rowspan="1" colspan="1">Total</td><td align="center" valign="middle" rowspan="1" colspan="1">34 (37)<xref ref-type="table-fn" rid="TFN2">*</xref></td><td align="center" valign="middle" rowspan="1" colspan="1">14 (15)<xref ref-type="table-fn" rid="TFN2">*</xref></td><td align="center" valign="middle" rowspan="1" colspan="1">2 (2)</td><td align="center" valign="middle" rowspan="1" colspan="1">2 (2)</td><td align="center" valign="middle" rowspan="1" colspan="1">52 (56)</td></tr></tbody></table><table-wrap-foot><p>PG: Pyogenic granuloma, PGCG: Peripheral giant cell granuloma, PT: Pregnancy tumor, EG: Epulis granulomatosum </p><fn id="TFN2"><label>*</label><p> Location of lesion was not recorded in the patient's record. ( 3 cases of Pyogenic granuloma, 1 case of Peripheral giant cell granuloma)</p></fn></table-wrap-foot></table-wrap></sec><sec sec-type="discussion"><title>Discussion</title><p>Reactive hyperplastic lesions are relatively common in centers of oral pathology. In the present study, the prevalence of reactive lesions was 20.2%, consistent with a report by Mashhadi Abbas et al. (<xref rid="B7" ref-type="bibr">7</xref>). This type of lesion also comprised 35.2%, 48%, and 39% of the total number of accessed biopsies in other studies from Iran (<xref rid="B8" ref-type="bibr">8</xref>-<xref rid="B10" ref-type="bibr">10</xref>). However, in reports by Effiom et al. (<xref rid="B1" ref-type="bibr">1</xref>), Reddy et al. (<xref rid="B3" ref-type="bibr">3</xref>), and Buchner et al. (<xref rid="B11" ref-type="bibr">11</xref>), reactive lesions accounted for 5.6%, 12.8%, and 6.7% of all cases. This variation in prevalence of reactive hyperplastic lesions in different countries could be due to different systems of classification and terminology of these lesions. In addition, geographical differences, as well as lifestyle and racial factors might have affected the results. </p><p>In the present study, the most frequent lesion was PG (41%), consistent with the findings of other studies (<xref rid="B1" ref-type="bibr">1</xref>,<xref rid="B8" ref-type="bibr">8</xref>,<xref rid="B12" ref-type="bibr">12</xref>-<xref rid="B14" ref-type="bibr">14</xref>). However, in studies by Hashemi pour et al. (<xref rid="B10" ref-type="bibr">10</xref>), Aghbali et al. (<xref rid="B9" ref-type="bibr">9</xref>), Reddy et al. (<xref rid="B3" ref-type="bibr">3</xref>), Buchner et al. (<xref rid="B11" ref-type="bibr">11</xref>), and Zhang et al. (<xref rid="B15" ref-type="bibr">15</xref>), the most common lesion was irritation fibroma. <xref ref-type="table" rid="T7">Table 7</xref> shows the relative frequency of oral cavity reactive lesions in different studies.</p><table-wrap id="T7" position="float"><label>Table 7</label><caption><p>Relative frequency of relative lesions of the oral cavity in various countries</p></caption><table frame="hsides" rules="groups"><thead><tr><th style="background-color:#D9D9D9;" align="left" valign="middle" rowspan="1" colspan="1"><bold>Lesion</bold></th><th style="background-color:#D9D9D9;" align="center" valign="middle" rowspan="1" colspan="1"><bold>FFH</bold></th><th style="background-color:#D9D9D9;" align="center" valign="middle" rowspan="1" colspan="1"><bold>PG</bold></th><th style="background-color:#D9D9D9;" align="center" valign="middle" rowspan="1" colspan="1"><bold>POF</bold></th><th style="background-color:#D9D9D9;" align="center" valign="middle" rowspan="1" colspan="1"><bold>PGCG</bold></th><th style="background-color:#D9D9D9;" align="center" valign="middle" rowspan="1" colspan="1"><bold>Total</bold></th></tr></thead><tbody><tr><td style="background-color:#D9D9D9;" align="left" valign="middle" rowspan="1" colspan="1">Study</td><td align="center" valign="middle" rowspan="1" colspan="1">No. (%)</td><td align="center" valign="middle" rowspan="1" colspan="1">No. (%)</td><td align="center" valign="middle" rowspan="1" colspan="1">No. (%)</td><td align="center" valign="middle" rowspan="1" colspan="1">No. (%)</td><td align="center" valign="middle" rowspan="1" colspan="1">No. (%)</td></tr><tr><td style="background-color:#D9D9D9;" align="left" valign="middle" rowspan="1" colspan="1">Kfir et al.(<xref rid="B16" ref-type="bibr">16</xref>)<break></break>1980 USA</td><td align="center" valign="middle" rowspan="1" colspan="1">414 (55.9)</td><td align="center" valign="middle" rowspan="1" colspan="1">199 (26.8)</td><td align="center" valign="middle" rowspan="1" colspan="1">78 (10.6)</td><td align="center" valign="middle" rowspan="1" colspan="1">50 (6.7)</td><td align="center" valign="middle" rowspan="1" colspan="1">741 (100)</td></tr><tr><td style="background-color:#D9D9D9;" align="left" valign="middle" rowspan="1" colspan="1">Stablein(<xref rid="B17" ref-type="bibr">17</xref>)<break></break>1985 USA</td><td align="center" valign="middle" rowspan="1" colspan="1">163 (35.4)</td><td align="center" valign="middle" rowspan="1" colspan="1">197 (42.8)</td><td align="center" valign="middle" rowspan="1" colspan="1">74 (16.1)</td><td align="center" valign="middle" rowspan="1" colspan="1">26 (5.7)</td><td align="center" valign="middle" rowspan="1" colspan="1">460 (100)</td></tr><tr><td style="background-color:#D9D9D9;" align="left" valign="middle" rowspan="1" colspan="1">Macleod and Soames (<xref rid="B18" ref-type="bibr">18</xref>)<break></break>1987 England</td><td align="center" valign="middle" rowspan="1" colspan="1">48 (24)</td><td align="center" valign="middle" rowspan="1" colspan="1">57 (28.5)</td><td align="center" valign="middle" rowspan="1" colspan="1">81 (40.5)</td><td align="center" valign="middle" rowspan="1" colspan="1">14 (7)</td><td align="center" valign="middle" rowspan="1" colspan="1">200 (100)</td></tr><tr><td style="background-color:#D9D9D9;" align="left" valign="middle" rowspan="1" colspan="1">Daley et al.(<xref rid="B19" ref-type="bibr">19</xref>)<break></break>1990 Canada</td><td align="center" valign="middle" rowspan="1" colspan="1">794 (61.2)</td><td align="center" valign="middle" rowspan="1" colspan="1">154 (11.9)</td><td align="center" valign="middle" rowspan="1" colspan="1">283 (21.8)</td><td align="center" valign="middle" rowspan="1" colspan="1">67 (5.1)</td><td align="center" valign="middle" rowspan="1" colspan="1">1298 (100)</td></tr><tr><td style="background-color:#D9D9D9;" align="left" valign="middle" rowspan="1" colspan="1">Zang et al.(<xref rid="B15" ref-type="bibr">15</xref>)<break></break>2007 China</td><td align="center" valign="middle" rowspan="1" colspan="1">1489 (61)</td><td align="center" valign="middle" rowspan="1" colspan="1">482 (19.8)</td><td align="center" valign="middle" rowspan="1" colspan="1">431 (17.7)</td><td align="center" valign="middle" rowspan="1" colspan="1">37 (1.5)</td><td align="center" valign="middle" rowspan="1" colspan="1">2439 (100)</td></tr><tr><td style="background-color:#D9D9D9;" align="left" valign="middle" rowspan="1" colspan="1">Zarei et al.(<xref rid="B20" ref-type="bibr">20</xref>)<break></break>2007 Iran</td><td align="center" valign="middle" rowspan="1" colspan="1">21 (18.9)</td><td align="center" valign="middle" rowspan="1" colspan="1">40 (36)</td><td align="center" valign="middle" rowspan="1" colspan="1">18 (16.2)</td><td align="center" valign="middle" rowspan="1" colspan="1">32 (28.9)</td><td align="center" valign="middle" rowspan="1" colspan="1">111 (100)</td></tr><tr><td style="background-color:#D9D9D9;" align="left" valign="middle" rowspan="1" colspan="1">Buchner et al.(<xref rid="B11" ref-type="bibr">11</xref>)<break></break>2010 Israel</td><td align="center" valign="middle" rowspan="1" colspan="1">532 (31.8)</td><td align="center" valign="middle" rowspan="1" colspan="1">488 (29.1)</td><td align="center" valign="middle" rowspan="1" colspan="1">341 (20.4)</td><td align="center" valign="middle" rowspan="1" colspan="1">314 (18.7)</td><td align="center" valign="middle" rowspan="1" colspan="1">1675 (100)</td></tr><tr><td style="background-color:#D9D9D9;" align="left" valign="middle" rowspan="1" colspan="1">Effiom et al.(<xref rid="B1" ref-type="bibr">1</xref>)<break></break>2011 Nigeria</td><td align="center" valign="middle" rowspan="1" colspan="1">61 (19.4)</td><td align="center" valign="middle" rowspan="1" colspan="1">179 (57)</td><td align="center" valign="middle" rowspan="1" colspan="1">64 (20.4)</td><td align="center" valign="middle" rowspan="1" colspan="1">10 (3.2)</td><td align="center" valign="middle" rowspan="1" colspan="1">314 (100)</td></tr><tr><td style="background-color:#D9D9D9;" align="left" valign="middle" rowspan="1" colspan="1">Reddy et al.(<xref rid="B3" ref-type="bibr">3</xref>)<break></break>2011 India</td><td align="center" valign="middle" rowspan="1" colspan="1">120 (57.4)</td><td align="center" valign="middle" rowspan="1" colspan="1">39 (18.7)</td><td align="center" valign="middle" rowspan="1" colspan="1">37 (17.7)</td><td align="center" valign="middle" rowspan="1" colspan="1">13 (6.22)</td><td align="center" valign="middle" rowspan="1" colspan="1">209 (100)</td></tr><tr><td style="background-color:#D9D9D9;" align="left" valign="middle" rowspan="1" colspan="1">Kashyap et al.(<xref rid="B21" ref-type="bibr">21</xref>)2013 India</td><td align="center" valign="middle" rowspan="1" colspan="1">35 (35)</td><td align="center" valign="middle" rowspan="1" colspan="1">42 (42)</td><td align="center" valign="middle" rowspan="1" colspan="1">18 (18)</td><td align="center" valign="middle" rowspan="1" colspan="1">10 (10)</td><td align="center" valign="middle" rowspan="1" colspan="1">100 (100)</td></tr></tbody></table></table-wrap><p>In the present study, the frequency of hemorrhagic lesions (62%) was greater than that of fibrous lesions (38%), consistent with the results of a study by Seyedmajidi et al. (<xref rid="B5" ref-type="bibr">5</xref>). However, in study by Saifi et al. (<xref rid="B8" ref-type="bibr">8</xref>), fibrous lesions were more common (fibrous lesions, 59%; hemorrhagic lesions, (41%).</p><p>In this study, the mean age of patients with reactive lesions was 33.95±17.75 years, consistent with the reports of Al-Khateeb, Effiom et al. (<xref rid="B1" ref-type="bibr">1</xref>) and Reddy et al. (<xref rid="B6" ref-type="bibr">6</xref>,<xref rid="B1" ref-type="bibr">1</xref>,<xref rid="B3" ref-type="bibr">3</xref>). The most common age group of patients presenting with reactive lesions was 21–40 years (35%), consistent with the report of Saifiet et al. (<xref rid="B8" ref-type="bibr">8</xref>). In contrast, the frequency of reactive lesions was higher among individuals under 40 years of age. These lesions are not common over 70 years of age because people in this age group are largely edentulous and do not usually receive regular dental checkups. Therefore, many asymptomatic lesions are not be detected in this group (<xref rid="B8" ref-type="bibr">8</xref>).</p><p>The frequency of hemorrhagic lesion was higher in the 21–40 age group, while frequency of fibrous lesions was higher in the 41–60 age group. In a report by Saifi et al. (<xref rid="B8" ref-type="bibr">8</xref>), similar to the present study and other studies, the age of appearance of fibrous reactive lesions was higher than that of hemorrhagic lesions. This may indicate that these reactive lesions begin as hemorrhagic lesions and are gradually converted to fibrous lesions. This conversion is associated with a decrease in inflammation, an increase in the formation of fibrous tissue, and calcification of hemorrhagic lesions (<xref rid="B8" ref-type="bibr">8</xref>). In the present study, 60.3% of reactive lesions were found in women; the male-to-female ratio was 1:1.45. Most of the available studies (<xref rid="B1" ref-type="bibr">1</xref>,<xref rid="B7" ref-type="bibr">7</xref>,<xref rid="B9" ref-type="bibr">9</xref>,<xref rid="B11" ref-type="bibr">11</xref>,<xref rid="B12" ref-type="bibr">12</xref>,<xref rid="B15" ref-type="bibr">15</xref>) have shown a higher prevalence of lesions in women compared with men. Only Jalayer Naderi et al. (<xref rid="B2" ref-type="bibr">2</xref>) reported a higher prevalence of these lesions in men. This difference may be due to ethnic differences across the various studies (<xref rid="B11" ref-type="bibr">11</xref>). A higher prevalence of these lesions in women may show the role of hormonal factors as predisposing factors in the development of these lesions (<xref rid="B7" ref-type="bibr">7</xref>,<xref rid="B8" ref-type="bibr">8</xref>) and it could reflect a greater attention in female patients to dental care (<xref rid="B3" ref-type="bibr">3</xref>,<xref rid="B7" ref-type="bibr">7</xref>).</p><p>In many studies (<xref rid="B2" ref-type="bibr">2</xref>,<xref rid="B5" ref-type="bibr">5</xref>,<xref rid="B7" ref-type="bibr">7</xref>,<xref rid="B9" ref-type="bibr">9</xref>,<xref rid="B10" ref-type="bibr">10</xref>,<xref rid="B16" ref-type="bibr">16</xref>,<xref rid="B20" ref-type="bibr">20</xref>,<xref rid="B22" ref-type="bibr">22</xref>) the gingiva was the most common location for reactive lesions, consistent with the results of the present study. The incidence of these lesions in the gingiva indicates that reactive lesions originate from the periodontal ligament and connective tissue (<xref rid="B2" ref-type="bibr">2</xref>). Furthermore, it could be due to the tendency of the interdental space to aggregation of bacterial plaque and food particles which cause the gingiva expose to chronic irritation (<xref rid="B11" ref-type="bibr">11</xref>).</p><p>The PG is a common tumor-like growth of the oral cavity that shows a striking predilection for the gingiva. Although PG can occur at any age, it is most prevalent in children and young adults. Most studies showed a definite female predilection (<xref rid="B5" ref-type="bibr">5</xref>). In this study, PG (the most prevalent hemorrhagic lesion) constituted 37% of the reactive lesions among patients with an average age of 30.4±14.9 years. Females were affected more than males and the most common site was gingiva; similar findings were reported by Effiom et al. (<xref rid="B1" ref-type="bibr">1</xref>).The predilection of PG for women may be due to effect of female hormones. Also the gingiva is a target organ for direct function of estrogen and progesterone (<xref rid="B1" ref-type="bibr">1</xref>).</p><p>The irritation fibroma account for the great majority of localized reactive lesions as was substantiated by various reports in literature. Although the irritation fibroma occurs anywhere in the oral cavity; but the buccal mucosa is the most common location. These lesions are most prevalent in the 4–6<sup>th </sup>decade of life, and the female-to-male ratio is almost 2:1 (<xref rid="B5" ref-type="bibr">5</xref>). In this study, irritation fibroma (the most common fibrous lesion) constituted 20% of the reactive lesions with among patients with an average age of 42.5±23.4 years. The most common site was the buccal mucosa, and males were affected more than females; similar to the Jalayer Naderi et al. report (<xref rid="B2" ref-type="bibr">2</xref>).</p><p>POF and PGCG showed a consistent pattern when compared with other studies (<xref rid="B1" ref-type="bibr">1</xref>,<xref rid="B3" ref-type="bibr">3</xref>). Unlike other oral reactive lesions they were limited to the gingiva. Eversole and Rovin indicated that being confined to the gingiva in POF and PGCG supports a histogenic derivation from the periodontal ligament (<xref rid="B1" ref-type="bibr">1</xref>).</p><p>In summary, in this study the prevalence of reactive lesions was 20.2%. The most common peripheral lesion was PG. The mean age of patients was 33.95±17.75 years and reactive lesions were more common in women. The most common locations of involvement were the gingiva and the alveolar mucosa of the mandible. 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