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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Cephalometric Evaluation of the Effect of Complete Dentures on Retropharyngeal Space and Its Effect on Spirometric Values in Altered Vertical Dimension</title><author><name sortKey="Gupta, Prachi" sort="Gupta, Prachi" uniqKey="Gupta P" first="Prachi" last="Gupta">Prachi Gupta</name><affiliation><nlm:aff id="I1">Department of Prosthodontics, Sharad Pawar Dental College, Datta Meghe Institute of Medical Sciences (Deemed University), Wardha 442004, Maharashtra, India</nlm:aff></affiliation></author><author><name sortKey="Thombare, Ram" sort="Thombare, Ram" uniqKey="Thombare R" first="Ram" last="Thombare">Ram Thombare</name><affiliation><nlm:aff id="I1">Department of Prosthodontics, Sharad Pawar Dental College, Datta Meghe Institute of Medical Sciences (Deemed University), Wardha 442004, Maharashtra, India</nlm:aff></affiliation></author><author><name sortKey="Pakhan, A J" sort="Pakhan, A J" uniqKey="Pakhan A" first="A. J." last="Pakhan">A. J. Pakhan</name><affiliation><nlm:aff id="I1">Department of Prosthodontics, Sharad Pawar Dental College, Datta Meghe Institute of Medical Sciences (Deemed University), Wardha 442004, Maharashtra, India</nlm:aff></affiliation></author><author><name sortKey="Singhal, Sameer" sort="Singhal, Sameer" uniqKey="Singhal S" first="Sameer" last="Singhal">Sameer Singhal</name><affiliation><nlm:aff id="I2">Department of Pulmonary Medicine, Jawaharlal Nehru Medical College, Datta Meghe Institute of Medical Sciences (Deemed University), Wardha 442004, Maharashtra, India</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">21991477</idno><idno type="pmc">3168939</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3168939</idno><idno type="RBID">PMC:3168939</idno><idno type="doi">10.5402/2011/516969</idno><date when="2011">2011</date><idno type="wicri:Area/Pmc/Corpus">002C76</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002C76</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Cephalometric Evaluation of the Effect of Complete Dentures on Retropharyngeal Space and Its Effect on Spirometric Values in Altered Vertical Dimension</title><author><name sortKey="Gupta, Prachi" sort="Gupta, Prachi" uniqKey="Gupta P" first="Prachi" last="Gupta">Prachi Gupta</name><affiliation><nlm:aff id="I1">Department of Prosthodontics, Sharad Pawar Dental College, Datta Meghe Institute of Medical Sciences (Deemed University), Wardha 442004, Maharashtra, India</nlm:aff></affiliation></author><author><name sortKey="Thombare, Ram" sort="Thombare, Ram" uniqKey="Thombare R" first="Ram" last="Thombare">Ram Thombare</name><affiliation><nlm:aff id="I1">Department of Prosthodontics, Sharad Pawar Dental College, Datta Meghe Institute of Medical Sciences (Deemed University), Wardha 442004, Maharashtra, India</nlm:aff></affiliation></author><author><name sortKey="Pakhan, A J" sort="Pakhan, A J" uniqKey="Pakhan A" first="A. J." last="Pakhan">A. J. Pakhan</name><affiliation><nlm:aff id="I1">Department of Prosthodontics, Sharad Pawar Dental College, Datta Meghe Institute of Medical Sciences (Deemed University), Wardha 442004, Maharashtra, India</nlm:aff></affiliation></author><author><name sortKey="Singhal, Sameer" sort="Singhal, Sameer" uniqKey="Singhal S" first="Sameer" last="Singhal">Sameer Singhal</name><affiliation><nlm:aff id="I2">Department of Pulmonary Medicine, Jawaharlal Nehru Medical College, Datta Meghe Institute of Medical Sciences (Deemed University), Wardha 442004, Maharashtra, India</nlm:aff></affiliation></author></analytic><series><title level="j">ISRN Dentistry</title><idno type="ISSN">2090-4371</idno><idno type="eISSN">2090-438X</idno><imprint><date when="2011">2011</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Role of complete dentures in reducing apnea-hypoapnea index in edentulous obstructive sleep apnea patient has shown promising results in previous studies. This study was undertaken to ascertain the role of complete denture and complete denture with slight increase in vertical dimension using custom made occlussal jig, on retropharyngeal space, posterior airway space, pharyngeal depth, and spirometric readings in comparison with those in edentulous group. Significant changes were observed in both intervention groups and thus, paving the way for doing further research for the consideration of using complete denture with modifications as an oral appliance in edentulous obstructive sleep apnea patient.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Bucca, C" uniqKey="Bucca C">C Bucca</name></author><author><name sortKey="Carossa, S" uniqKey="Carossa S">S Carossa</name></author><author><name sortKey="Pivetti, S" uniqKey="Pivetti S">S Pivetti</name></author><author><name sortKey="Gai, V" uniqKey="Gai V">V Gai</name></author><author><name sortKey="Rolla, G" uniqKey="Rolla G">G Rolla</name></author><author><name sortKey="Preti, G" uniqKey="Preti G">G Preti</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bucca, Cb" uniqKey="Bucca C">CB Bucca</name></author><author><name sortKey="Carossa, S" uniqKey="Carossa S">S Carossa</name></author><author><name 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<front><journal-meta><journal-id journal-id-type="nlm-ta">ISRN Dent</journal-id><journal-id journal-id-type="iso-abbrev">ISRN Dent</journal-id><journal-id journal-id-type="publisher-id">DENTISTRY</journal-id><journal-title-group><journal-title>ISRN Dentistry</journal-title></journal-title-group><issn pub-type="ppub">2090-4371</issn><issn pub-type="epub">2090-438X</issn><publisher><publisher-name>International Scholarly Research Network</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">21991477</article-id><article-id pub-id-type="pmc">3168939</article-id><article-id pub-id-type="doi">10.5402/2011/516969</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title>Cephalometric Evaluation of the Effect of Complete Dentures on Retropharyngeal Space and Its Effect on Spirometric Values in Altered Vertical Dimension</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Gupta</surname><given-names>Prachi</given-names></name><xref ref-type="aff" rid="I1"><sup>1</sup></xref><xref ref-type="corresp" rid="cor1">*</xref></contrib><contrib contrib-type="author"><name><surname>Thombare</surname><given-names>Ram</given-names></name><xref ref-type="aff" rid="I1"><sup>1</sup></xref></contrib><contrib contrib-type="author"><name><surname>Pakhan</surname><given-names>A. J.</given-names></name><xref ref-type="aff" rid="I1"><sup>1</sup></xref></contrib><contrib contrib-type="author"><name><surname>Singhal</surname><given-names>Sameer</given-names></name><xref ref-type="aff" rid="I2"><sup>2</sup></xref></contrib></contrib-group><aff id="I1"><sup>1</sup>Department of Prosthodontics, Sharad Pawar Dental College, Datta Meghe Institute of Medical Sciences (Deemed University), Wardha 442004, Maharashtra, India</aff><aff id="I2"><sup>2</sup>Department of Pulmonary Medicine, Jawaharlal Nehru Medical College, Datta Meghe Institute of Medical Sciences (Deemed University), Wardha 442004, Maharashtra, India</aff><author-notes><corresp id="cor1">*Prachi Gupta: <email>singhal_prachi@yahoo.co.in</email></corresp><fn fn-type="other"><p>Academic Editor: M. Awad</p></fn></author-notes><pub-date pub-type="ppub"><year>2011</year></pub-date><pub-date pub-type="epub"><day>4</day><month>7</month><year>2011</year></pub-date><volume>2011</volume><elocation-id>516969</elocation-id><history><date date-type="received"><day>15</day><month>4</month><year>2011</year></date><date date-type="accepted"><day>24</day><month>5</month><year>2011</year></date></history><permissions><copyright-statement>Copyright © 2011 Prachi Gupta et al.</copyright-statement><copyright-year>2011</copyright-year><license xlink:href="https://creativecommons.org/licenses/by/3.0/"><license-p>This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</license-p></license></permissions><abstract><p>Role of complete dentures in reducing apnea-hypoapnea index in edentulous obstructive sleep apnea patient has shown promising results in previous studies. This study was undertaken to ascertain the role of complete denture and complete denture with slight increase in vertical dimension using custom made occlussal jig, on retropharyngeal space, posterior airway space, pharyngeal depth, and spirometric readings in comparison with those in edentulous group. Significant changes were observed in both intervention groups and thus, paving the way for doing further research for the consideration of using complete denture with modifications as an oral appliance in edentulous obstructive sleep apnea patient.</p></abstract></article-meta></front><body><sec id="sec1"><title>1. Introduction</title><p>Edentulism leads to decrease in size and tone of the pharyngeal musculature and is a crucial risk factor for obstructive sleep apnea (OSA) [<xref rid="B1" ref-type="bibr">1</xref>–<xref rid="B3" ref-type="bibr">3</xref>]. Literature review reveals that in a patient with obstructive sleep apnea, extraction of all teeth manifested worsening of the cardiorespiratory symptoms associated with almost doubling of the number of episodes of apnea/hypopnea per hour [<xref rid="B3" ref-type="bibr">3</xref>]. Obstructive sleep apnea syndrome (OSAS) is a disorder characterised by repeated obstruction of the upper airway, with consequent episodes of apnea and hypopnea during sleep, snoring, and daytime sleepiness [<xref rid="B4" ref-type="bibr">4</xref>, <xref rid="B5" ref-type="bibr">5</xref>]. Increased pharyngeal collapsibility is reported to be a common cause of obstructive sleep apnea. It may be functional in nature, namely, muscular hypotonicity or anatomic in character due to conditions like macroglossia, retrognathia, micrognathiam, and soft tissue hyperplasia leading to reduction in size of the lumen of the airway. </p><p>Loss of vertical dimension of occlusion which causes reduction of the lower face height and rotation of the mandible are some of the conditions which may lead to obstructive sleep apnea. In edentulous patients while recording lung function tests without dentures produces mild but significant decrease in inspiratory airflow rates [<xref rid="B2" ref-type="bibr">2</xref>], this may be suggestive of same threat to the patency of upper airway. Obstructive sleep apnea is a common disorder, especially in elderly people older than 50 years. About 61% of this group is estimated to meet the minimum criteria for obstructive sleep apnea [<xref rid="B6" ref-type="bibr">6</xref>]. Providing prosthodontic appliances, namely, mandibular repositioning devices and tongue repositioning devices may comply with the need as a treatment modality for these patients who present surgical risks or have had unsuccessful response to surgical procedures [<xref rid="B4" ref-type="bibr">4</xref>]. This study was undertaken to ascertain the role of complete dentures on modifications in the position of the jaw, tongue, soft tissues, and retropharyngeal space, thus precluding obstructive sleep apnea by restoring the lost vertical dimension and also to evaluate the effect of providing slight increase in vertical dimension of occlusion in same patient as well as to see the effect of same interventions on spirometric readings.</p></sec><sec id="sec2"><title>2. Materials and Methods</title><p>The 20 edentulous patients visiting the Department of Prosthodontics, complete denture prosthesis, were selected as subjects for this study. Following criteria of selection of the subjects were strictly adhered to: age group ranging between 40–70 years; healthy subjects from both genders with no systemic involvement especially respiratory diseases; residual alveolar ridge should be well formed/average; cooperative nature. All these patients were informed about the nature of study and the level of cooperation needed from them. After obtaining written consent, they were used for this study. The approval from Institutional Ethic Committee was obtained before the start of this study. The study was performed as follows.</p><p><statement id="head1"><title>(I) Fabricating Complete Denture for Selected Subjects</title><p>Routine procedure of impression making, recording jaw relation, selection, and arrangement of teeth was followed. After approval of try-in of waxed denture, they were processed following conventional method, using standard material for all subjects. Complete dentures so fabricated were provided proper vertical dimension of occlusion (<xref ref-type="fig" rid="fig1">Figure 1(a)</xref>).</p></statement></p><p><statement id="head2"><title>(II) Making of an Acrylic Occlusal JIG (<xref ref-type="fig" rid="fig2">Figure 2(a)</xref>)</title><p>For increasing vertical dimension of occlusion while shooting lateral cephalograph, an acrylic occlusal JIG was prepared using autopolymerising acrylic resin. About 2-3 mm thickness at posterior wings were provided to this acrylic JIG having wire loop as a handle.</p></statement></p><p><statement id="head3"><title>(III) Shooting Lateral Cephalographs</title><p>Standardized lateral cephalographs were shooted using natural head posture (mirror technique) at end expiration, without swallowing and in centric occlusion. The source should be a minimum of 5 feet from the cassette. The centre X-ray beam was directed perpendicular to the right external auditory meatus. The time of exposure for an adult at this distance with medium speed cassette and medium speed film was 8/10 of a second at 70 KV and 12 mA value. Due precaution was taken during the procedure to avoid radiation hazards.</p></statement></p><p><statement id="head4"><title>Three lateral cephalographs for the same subject were shooted:</title><p><list list-type="roman-lower"><list-item><p>lateral cephalograph of edentulous subjects (<xref ref-type="fig" rid="fig3">Figure 3(a)</xref>),</p></list-item><list-item><p>lateral cephalograph (<xref ref-type="fig" rid="fig3">Figure 3(b)</xref>) of same edentulous subject wearing complete denture with acceptable vertical dimension of occlusion (<xref ref-type="fig" rid="fig1">Figure 1(a)</xref>),</p></list-item><list-item><p>lateral cephalograph (<xref ref-type="fig" rid="fig3">Figure 3(c)</xref>) of same edentulous subject wearing complete denture having raised vertical dimension of occlusion using acrylic JIG with putty index (<xref ref-type="fig" rid="fig1">Figure 1(b)</xref>).</p></list-item></list></p><p>Occlusal JIG coated with putty on both sides was interposed between the upper and lower complete dentures in posterior region. Patient was advised to close the jaw for obtaining occlusal index of teeth in putty (<xref ref-type="fig" rid="fig2">Figure 2(b)</xref>). This will cause rise in vertical dimension of occlusion (Figures <xref ref-type="fig" rid="fig2">2(c)</xref> and <xref ref-type="fig" rid="fig1">1(b)</xref>). The lateral cephalograph was then shooted after hardening of putty index. This will stabilize both dentures while shooting cephalograph. Same procedure was followed for all 20 subjects used in this study. These cephalographs were then developed using standard technique.</p></statement></p><p><statement id="head5"><title>(IV) Tracing of Lateral Cephalograph</title><p>An acetate tracing paper of proper size was affixed to the cephalograph with scotch tape. The tape was placed on the left side of the tracing paper. The cephalograph was then positioned on the X-ray illuminating table (X-ray viewer) so that the profile faces the right when it was viewed. A tracing was done following usual orthodontic practice [<xref rid="B7" ref-type="bibr">7</xref>]. A sharp, HB pencil and a plastic transparent 6 inches ruler was used for tracing (<xref ref-type="fig" rid="fig4">Figure 4</xref>).</p></statement></p><p><statement id="head6"><title>Following cephalometric reference points were identified:</title><p><list list-type="roman-lower"><list-item><p>Lp—point on anterior wall of oropharynx,</p></list-item><list-item><p>Mp—point on posterior wall of oropharynx,</p></list-item><list-item><p>cv2ia—the most anteroinferior point on the corpus of the second cervical vertebrae,</p></list-item><list-item><p>cv4ia—the most anteroinferior point on the corpus of the fourth cervical vertebrae,</p></list-item><list-item><p>ppw2—the posterior pharyngeal wall along the line intersecting Cv2ia and hy, </p></list-item><list-item><p>ppw4—the posterior pharyngeal wall along the line intersecting Cv4ia and hy,</p></list-item><list-item><p>hy—the most superior and anterior point on the body hyoid bone,</p></list-item><list-item><p>apw2—the anterior pharyngeal wall along the line intersecting cv2ia and hy, </p></list-item><list-item><p>apw4—the anterior pharyngeal wall along the line intersecting cv4ia and hy,</p></list-item><list-item><p>tb—the intersection point of a line from point B through go and the base of the tongue,</p></list-item><list-item><p>Point B—(supramentale)—the point at the deepest midline concavity on the mandibular symphysis between infradentale and pogonion,</p></list-item><list-item><p>go—gonion—the constructed point of intersection of the ramus plane and the mandibular plane,</p></list-item><list-item><p>Po—porion—the superior point of the external auditory meatus,</p></list-item><list-item><p>Or—orbitale—the lowest point in the inferior margin of the orbit,</p></list-item><list-item><p>ppwb—the intersection point of a line from B through go and the base of the posterior pharyngeal wall, </p></list-item><list-item><p>Mp-Lp(Retropharyngeal space [RPS])—the smallest distance between the anterior (Lp) and posterior wall of oropharynx,</p></list-item><list-item><p>apw2-ppw2—pharyngeal depth at level of second cervical,</p></list-item><list-item><p>apw4-ppw4—pharyngeal depth at level of fourth cervical vertebrae.</p></list-item></list>PAS (posterior airway space) is linear distance between a point on the base of tounge (tb) and another point on the posterior pharyngeal wall (ppwb), both determined by an extension of line from point B through go.</p><p>Tracings were done for all subjects for all three groups of lateral cephalographs (Figures <xref ref-type="fig" rid="fig3">3(a)</xref>, <xref ref-type="fig" rid="fig3">3(b)</xref>, and <xref ref-type="fig" rid="fig3">3(c)</xref>). Readings were obtained using digital caliper.</p></statement></p><p><statement id="head7"><title>(V) Spirometric Technique and Analysis</title><p>Spirometry (Pulmonary Function Test) is a simple method of studying pulmonary ventilation by recording movements of air into and out of the lungs. Spirometry was done with spirometer with prior informed consent of patient (<xref ref-type="fig" rid="fig5">Figure 5</xref>). Acceptability criteria [<xref rid="B8" ref-type="bibr">8</xref>] included spirogram having good starts with extrapolated volume <5% of FVC or 0.15 Lt and satisfactory exhalation of 6 seconds or a plateau in volume-time curve. After three acceptable spirograms were recorded, reproducibility criteria were applied. The two largest FVC values within 0.2 Lt of each other and the two largest FEV1 values within 0.2 Lt of each other were taken. When both of these criteria were met, the session was concluded. </p></statement></p><p><statement id="head8"><title>The Test Was Performed</title><p><list list-type="order"><list-item><p>for edentulous subjects (Without denture),</p></list-item><list-item><p>for same subjects with complete denture having acceptable vertical dimension of occlusion,</p></list-item><list-item><p>for same subjects with complete denture after increasing vertical dimension of occlusion by using occlusal JIG with putty index.</p></list-item></list></p></statement></p><p><statement id="head9"><title>Following Variables Were Taken into Consideration [<xref rid="B8" ref-type="bibr">8</xref>]</title><p><list list-type="order"><list-item><p>FVC—It equals the amount of air that can be forcefully exhaled after complete inspiration.</p></list-item><list-item><p>FEV1—It equals the volume of air exhaled during the first second of expiration.</p></list-item><list-item><p>FEV1/FVC—Ratio is an invaluable indicator of respiratory disease and allows separation of ventilatory abnormalities into “restrictive” or “obstructive” patterns.</p></list-item><list-item><p>PIFR—It is peak inspiratory flow rate during inspiration and represents extrathoracic airways.</p></list-item></list></p></statement></p></sec><sec id="sec3"><title>3. Results</title><p>The careful evaluation of the lateral cephalographs was carried out for all subjects used in this study, and the values so recorded (<xref ref-type="table" rid="tab1">Table 1</xref>) were compared with edentulous subjects (control group) to know the effect on the retropharyngeal space, when complete dentures were used by same patients having acceptable vertical dimension of occlusion (first interventional group) and also by increasing vertical dimension of occlusion using acrylic JIG with putty index (second interventional group). Applying One-way ANOVA, Dunnett “<italic>D</italic>” test and unpaired “<italic>t</italic>” test, significant variations were found in retropharyngeal space, posterior airway space, pharyngeal depth at level of second cervical vertebrae and peak inspiratory flow rates between control and interventional groups and among first and second interventional groups, whereas no significant variations were seen in FVC, Fev1 and Fev1%. Pharyngeal depth at level of fourth cervical vertebrae showed significant variations only between control group and second interventional group (<xref ref-type="table" rid="tab2">Table 2</xref>). </p></sec><sec id="sec4"><title>4. Discussion</title><p>It is an established fact that edentulous patients tend to experience obstructive sleep apnea at a higher incidence than that of general population [<xref rid="B9" ref-type="bibr">9</xref>]. Loss or absence of teeth produces prominent anatomical changes that may influence upper airway size and function, such as loss of the vertical dimension of occlusion resulting into reduction of the lower face height and mandible rotation [<xref rid="B10" ref-type="bibr">10</xref>]. Rehabilitation of edentulous patient with complete dentures is an integral part of prosthodontic treatment modality. A denture not only provides esthetics and improves the phonetics but also restores the desired function of mastication and also provides adequate support to orofacial structures by restoring altered vertical dimension of face and also improves the conditions like OSA/hypopnea.</p><p> Few studies have been done in past to investigate the role of complete denture in reducing apnea-hypopnea index in edentulous obstructive sleep apneic patients [<xref rid="B1" ref-type="bibr">1</xref>–<xref rid="B3" ref-type="bibr">3</xref>, <xref rid="B11" ref-type="bibr">11</xref>]. Very few studies were carried out to evaluate the effect of wearing complete dentures in edentulous patients on spirometric readings [<xref rid="B2" ref-type="bibr">2</xref>].</p><p>These studies reported in literature have demonstrated that wearing complete dentures causes increase in the retropharyngeal space in supine position in edentulous patient with obstructive sleep apnea thereby reducing the severity of apnea-hypopnea events. The effect of complete denture fabricated with acceptable vertical dimension of occlusion and with increased vertical dimension of occlusion on retropharyngeal space and spirometric values in normal healthy edentulous patients has never been investigated in past. The present study was based on strong assumption that increasing the vertical dimension of occlusion by about 2-3 mm using custom made acrylic occlusal JIG would further result in increase in the retropharyngeal space. </p><p>The subjects selected for this study were normal edentulous patients, and the fabrication of complete dentures using standard conventional method and routine materials provided a homogenous and representative sample. The clinical material used in study consisted of both male and female patients.</p><p>The present study demonstrated that significant changes were observed in retropharyngeal space with wearing of complete dentures fabricated with acceptable vertical dimension of occlusion (mean increase of 2.16 mm with “<italic>P</italic>” value < 0.05) in comparison to edentulous subjects. These changes were found to be more significant in same subjects after increasing vertical dimension of occlusion using custom made acrylic JIG (mean increase of 4.92 mm with “<italic>P</italic>” value < 0.05) in comparison to edentulous subjects. A similar study [<xref rid="B1" ref-type="bibr">1</xref>] carried out in past with 6 edentulous patients showed that removal of dentures lead to a striking decrease in retropharyngeal space from 15 mm to 6 mm, leading to increased severity of apnea-hypopnea events. Later on same results were obtained in another study [<xref rid="B3" ref-type="bibr">3</xref>] in which the authors hypothesized that edentulism might act in creating the apnoea condition by modifying anatomy and thereby affecting the functions of the pharyngeal airway and of tongue and may be by favouring inflammatory edema. Thus, they suggested that the advantage of removing dentures during sleep should be weighted against the risk of favouring upper airway collapse. </p><p>It is also noticed in this study that significant changes were observed in posterior airway space, and pharyngeal depth at level of second cervical vertebrae in both the intervention groups; complete denture with acceptable vertical dimension of occlusion demonstrated mean increase of 1.88 mm in posterior airway space, and mean increase of 2.20 mm in pharyngeal depth in comparison to edentulous subjects with “<italic>P</italic>” value <0.05 and the complete denture after increasing vertical dimension of occlusion using custom made acrylic JIG of about 2-3 mm thickness, exhibited mean increase of 4.47 mm in posterior airway space and mean increase of 5.11 mm in pharyngeal depth at same level in comparison to edentulous subjects with “<italic>P</italic>” value < 0.05. </p><p>In obstructive sleep apnea patients, there is an unusually small posterior airway space measurement and several bony structures surrounding the oropharynx which could be involved in the anatomic disarrangement leading to obstructive sleep apnea [<xref rid="B12" ref-type="bibr">12</xref>]. Meyer and Knudson in 1990 fabricated prosthesis to establish a vertical and protrusive jaw position in edentulous patients with obstructive sleep apnea and found that posterior airway space increased significantly with the prosthesis in edentulous patient [<xref rid="B13" ref-type="bibr">13</xref>]. Robertson CJ in 1998 theorized that increasing the vertical dimension of occlusion during fabrication of prosthesis for edentulous patient with obstructive sleep apnea was essential to ensure that dislodgement did not occur nocturnally [<xref rid="B14" ref-type="bibr">14</xref>]. Thus results are in agreement with the findings of this study.</p><p>In the latest study done in Japan, authors found that wearing complete dentures during sleep improves the apnea-hypopnea index in most of the patients. They further stated that this effect was due to reduction in partial pharyngeal obstruction when patient wore complete dentures during sleep [<xref rid="B11" ref-type="bibr">11</xref>].</p><p>Many researchers advocated that increase in posterior airway space could be achieved by advancing the mandible forward with or without the use of tongue retaining device and without increasing the vertical dimension of occlusion [<xref rid="B15" ref-type="bibr">15</xref>–<xref rid="B18" ref-type="bibr">18</xref>]. A mandibular advancement splint was used for edentulous obstructive sleep apnea patient using clinical procedures that were similar to those for fabricating a conventional complete denture without increasing the vertical dimension of occlusion. [<xref rid="B16" ref-type="bibr">16</xref>] A new functional appliance with combine characteristics of mandibular advancement splint and tongue retaining device with a custom made tongue tip housing without increasing vertical dimension of occlusion was fabricated for an edentulous obstructive sleep apnea patient popularly named as mandibular and tongue repositioner (MTR) [<xref rid="B18" ref-type="bibr">18</xref>]. </p><p>An oral appliance fabricated like a denture with artificial teeth that not only reduced the severity of obstructive events but also provided an esthetic look to the patient with moderate obstructive sleep apnoea [<xref rid="B17" ref-type="bibr">17</xref>]. An implant retained mandibular repositioning appliance in the mandible was provided as a viable treatment modality in edentulous obstructive sleep apnea patients in another case report [<xref rid="B19" ref-type="bibr">19</xref>] documented in year 2007.</p><p>The advantage of using dentures in edentulous patient during sleep resulted in reducing apnea-hypopnea events in edentulous obstructive sleep apnea patient. This occurred due to the fact that wearing dentures induces modifications in the position of the jaw, tongue, soft tissue, and pharyngeal airway space [<xref rid="B20" ref-type="bibr">20</xref>] that may contribute to the reduction of apnea events. Moreover, since wearing complete dentures might not change the horizontal mandibular position as oral appliance do, it might help to restore the vertical mandibular position. Thus, the denture itself can act as an oral appliance and provides esthetic look to the patient. The result of this study is in confirmation of the above findings. Significant increase in retropharyngeal space (“<italic>P</italic>” value = 0.004) and posterior airway space (“<italic>P</italic>” value = 0.015) in “complete denture after increasing vertical dimension of occlusion” as compared to “complete denture with acceptable vertical dimension of occlusion” was observed. </p><p>The disadvantages of wearing dentures during sleep are due to the fact that they are associated with chronic inflammatory changes, [<xref rid="B21" ref-type="bibr">21</xref>] leading to irritation and alveolar bone resorption in the denture-supporting area. In addition, increasing the vertical dimension of occlusion can cause strain on temporomandibular joint, and patient may need more time for adaptation to the same. </p><p>The spirometric values were assessed with the wearing of complete denture with acceptable vertical dimension of occlusion and with increased vertical dimension of occlusion. It was observed that peak inspiratory flow rates (PIFR) were increased significantly in both intervention groups as compared with the values in edentulous state of the subjects. However, there were no significant changes in forced vital capacity, forced expiratory volume in 1 second, and FEV1% in intervention groups in comparison to edentulous subjects. This suggested that wearing dentures with acceptable vertical dimension of occlusion and increased vertical dimension of occlusion has significant effect on extrathoracic airways including retropharyngeal space. The increase in mean PIFR might be due to increase in retropharngeal space after wearing complete dentures, and results are in agreement with the findings of previous studies [<xref rid="B2" ref-type="bibr">2</xref>, <xref rid="B3" ref-type="bibr">3</xref>]. </p><p>Pellegrino et al. have also concluded that maximum inspiratory flow (PIF) is largely decreased with an extrathoracic airway obstruction, because the pressure surrounding the airways (which is almost equal to atmospheric) cannot oppose the negative intraluminal pressure generated with the inspiratory effort [<xref rid="B22" ref-type="bibr">22</xref>]. In contrast, it is little affected by an intrathoracic airway obstruction.</p><p>Thus, edentulous patients with obstructive sleep apnea may or may not use dentures during spirometric analysis of lung function test for assessment of intrathoracic airways (like for differentiating obstructive from restrictive lung diseases) but should always use dentures for assessment of extrathoracic airways (like in cases of obstructive sleep apnea patients, paratracheal tumours, paratracheal lymphadenopathy, and laryngeal inflammation). </p><p>Therefore, this study can provide a breakthrough for further evaluation of the effect of increasing the vertical dimension of occlusion within acceptable limits in edentulous patients with obstructive sleep apnea and on spirometric parameters in future studies.</p></sec><sec id="sec5"><title>5. Conclusion</title><list list-type="order"><list-item><p>In edentulous subjects, the retropharyngeal space (RPS) and posterior airway space (PAS) were observed to be reduced. This was due to anatomical changes causing decrease in vertical dimension resulting into collapse of orofacial structures. </p></list-item><list-item><p>In same edentulous subjects, after wearing complete dentures having acceptable VDO, the retropharyngeal space (RPS) and posterior airway space (PAS) were found to be increased which was due to restored vertical dimension of occlusion. </p></list-item><list-item><p>When same edentulous subjects wearing complete denture after increasing vertical dimension of occlusion was subjected to analysis of these values (RPS & PAS), it was observed that there was marked increase in these values more than the values observed in same subjects wearing complete dentures with acceptable vertical dimension of occlusion.</p></list-item><list-item><p>Peak inspiratory flow rate was observed to be increased in subjects wearing complete dentures with acceptable vertical dimension of occlusion as well as increased vertical dimension of occlusion. This increase in PIFR was slight on higher side in subjects wearing complete denture with increased VDO as compared to acceptable VDO. </p></list-item><list-item><p>These significant differences are important from the point of view of edentulous patients having obstructive sleep apnea in which there are unusually small retropharyngeal and posterior airway spaces. 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pub-id-type="pmid">15985983</pub-id></element-citation></ref><ref id="B21"><label>21</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Marcus</surname><given-names>PA</given-names></name><name><surname>Joshi</surname><given-names>A</given-names></name><name><surname>Jones</surname><given-names>JA</given-names></name><name><surname>Morgano</surname><given-names>SM</given-names></name></person-group><article-title>Complete edentulism and denture use for elders in New England</article-title><source><italic>Journal of Prosthetic Dentistry</italic></source><year>1996</year><volume>76</volume><issue>3</issue><fpage>260</fpage><lpage>266</lpage><pub-id pub-id-type="pmid">8887798</pub-id></element-citation></ref><ref id="B22"><label>22</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Pellegrino</surname><given-names>R</given-names></name><name><surname>Viegi</surname><given-names>G</given-names></name><name><surname>Brusasco</surname><given-names>V</given-names></name><etal></etal></person-group><article-title>Interpretative strategies for lung function tests</article-title><source><italic>European Respiratory Journal</italic></source><year>2005</year><volume>26</volume><issue>5</issue><fpage>948</fpage><lpage>968</lpage><pub-id pub-id-type="pmid">16264058</pub-id></element-citation></ref></ref-list></back><floats-group><fig id="fig1" position="float"><label>Figure 1</label><caption><p>(a) Patient wearing complete denture with acceptable VDO. (b) Patient wearing complete denture with increased VDO by using acrylic JIG.</p></caption><graphic xlink:href="DENTISTRY2011-516969.001"></graphic></fig><fig id="fig2" position="float"><label>Figure 2</label><caption><p>(a) Custom made acrylic occlusal JIG. (b) Occlusal surface of teeth registered in putty. (c) Increasing vertical dimension by using acrylic JIG.</p></caption><graphic xlink:href="DENTISTRY2011-516969.002"></graphic></fig><fig id="fig3" position="float"><label>Figure 3</label><caption><p>(a) Lateral cephalograph of the edentulous subject. (b) Lateral cephalograph of the same subject with acceptable VDO. (c) Lateral cephalograph of the same subject with increased VDO.</p></caption><graphic xlink:href="DENTISTRY2011-516969.003"></graphic></fig><fig id="fig4" position="float"><label>Figure 4</label><caption><p>Cephalometric points used in the study.</p></caption><graphic xlink:href="DENTISTRY2011-516969.004"></graphic></fig><fig id="fig5" position="float"><label>Figure 5</label><caption><p>Patient performing spirometry.</p></caption><graphic xlink:href="DENTISTRY2011-516969.005"></graphic></fig><table-wrap id="tab1" position="float"><label>Table 1</label><caption><p>Recorded lateral cephalograph and spirometric values. </p></caption><table frame="hsides" rules="groups"><thead><tr><th align="left" rowspan="1" colspan="1"></th><th align="left" rowspan="1" colspan="1"></th><th align="center" rowspan="1" colspan="1">Range<break></break> (Min.–Max. value)</th><th align="center" rowspan="1" colspan="1">Mean value</th><th align="center" rowspan="1" colspan="1">Percentage increase in comparison to control group</th></tr></thead><tbody><tr><td align="left" rowspan="3" colspan="1">Retropharyngeal space (Mp-Lp) in mm</td><td align="left" rowspan="1" colspan="1">Edentulous subjects (control group)</td><td align="center" rowspan="1" colspan="1">6.59–20.18</td><td align="center" rowspan="1" colspan="1">11.97</td><td align="center" rowspan="1" colspan="1">0%</td></tr><tr><td align="left" rowspan="1" colspan="1">First interventional group</td><td align="center" rowspan="1" colspan="1">9.64–22.32</td><td align="center" rowspan="1" colspan="1">14.14</td><td align="center" rowspan="1" colspan="1">18.12%</td></tr><tr><td align="left" rowspan="1" colspan="1">Second interventional group</td><td align="center" rowspan="1" colspan="1">12.73–22.78</td><td align="center" rowspan="1" colspan="1">16.90</td><td align="center" rowspan="1" colspan="1">41.18%</td></tr><tr><td align="center" colspan="5" rowspan="1"><hr></hr></td></tr><tr><td align="left" rowspan="3" colspan="1">Posterior airway space in mm</td><td align="left" rowspan="1" colspan="1">Edentulous subjects (control group)</td><td align="center" rowspan="1" colspan="1">6.08–23.07</td><td align="center" rowspan="1" colspan="1">12.63</td><td align="center" rowspan="1" colspan="1">0%</td></tr><tr><td align="left" rowspan="1" colspan="1">First interventional group</td><td align="center" rowspan="1" colspan="1">7.98–24.96</td><td align="center" rowspan="1" colspan="1">14.50</td><td align="center" rowspan="1" colspan="1">14.80%</td></tr><tr><td align="left" rowspan="1" colspan="1">Second interventional group</td><td align="center" rowspan="1" colspan="1">12.59–26.06</td><td align="center" rowspan="1" colspan="1">17.10</td><td align="center" rowspan="1" colspan="1">35.39%</td></tr><tr><td align="center" colspan="5" rowspan="1"><hr></hr></td></tr><tr><td align="left" rowspan="3" colspan="1">apw2-ppw2 in mm</td><td align="left" rowspan="1" colspan="1">Edentulous subjects (control group)</td><td align="center" rowspan="1" colspan="1">8.98–22.15</td><td align="center" rowspan="1" colspan="1">13.55</td><td align="center" rowspan="1" colspan="1">0%</td></tr><tr><td align="left" rowspan="1" colspan="1">First interventional group</td><td align="center" rowspan="1" colspan="1">9.92–24.39</td><td align="center" rowspan="1" colspan="1">15.75</td><td align="center" rowspan="1" colspan="1">16.23%</td></tr><tr><td align="left" rowspan="1" colspan="1">Second interventional group</td><td align="center" rowspan="1" colspan="1">14.95–25.48</td><td align="center" rowspan="1" colspan="1">18.67</td><td align="center" rowspan="1" colspan="1">37.78%</td></tr><tr><td align="center" colspan="5" rowspan="1"><hr></hr></td></tr><tr><td align="left" rowspan="3" colspan="1">apw4-ppw4 in mm</td><td align="left" rowspan="1" colspan="1">Edentulous subjects (control group)</td><td align="center" rowspan="1" colspan="1">10.56–26.44</td><td align="center" rowspan="1" colspan="1">18.74</td><td align="center" rowspan="1" colspan="1">0%</td></tr><tr><td align="left" rowspan="1" colspan="1">First interventional group</td><td align="center" rowspan="1" colspan="1">12.56–27.07</td><td align="center" rowspan="1" colspan="1">20.33</td><td align="center" rowspan="1" colspan="1">8.48%</td></tr><tr><td align="left" rowspan="1" colspan="1">Second interventional group</td><td align="center" rowspan="1" colspan="1">14.08–31.97</td><td align="center" rowspan="1" colspan="1">22.01</td><td align="center" rowspan="1" colspan="1">17.44%</td></tr><tr><td align="center" colspan="5" rowspan="1"><hr></hr></td></tr><tr><td align="left" rowspan="3" colspan="1">FVC in % predicted</td><td align="left" rowspan="1" colspan="1">Edentulous subjects (control group)</td><td align="center" rowspan="1" colspan="1">54–98</td><td align="center" rowspan="1" colspan="1">76.75</td><td align="center" rowspan="1" colspan="1">0%</td></tr><tr><td align="left" rowspan="1" colspan="1">First interventional group</td><td align="center" rowspan="1" colspan="1">63–98</td><td align="center" rowspan="1" colspan="1">77.35</td><td align="center" rowspan="1" colspan="1">0.78%</td></tr><tr><td align="left" rowspan="1" colspan="1">Second interventional group</td><td align="center" rowspan="1" colspan="1">60–97</td><td align="center" rowspan="1" colspan="1">77.95</td><td align="center" rowspan="1" colspan="1">1.56%</td></tr><tr><td align="center" colspan="5" rowspan="1"><hr></hr></td></tr><tr><td align="left" rowspan="3" colspan="1">Fev1 in % predicted</td><td align="left" rowspan="1" colspan="1">Edentulous subjects (control group)</td><td align="center" rowspan="1" colspan="1">54–101</td><td align="center" rowspan="1" colspan="1">76.30</td><td align="center" rowspan="1" colspan="1">0%</td></tr><tr><td align="left" rowspan="1" colspan="1">First interventional group</td><td align="center" rowspan="1" colspan="1">48–103</td><td align="center" rowspan="1" colspan="1">77.40</td><td align="center" rowspan="1" colspan="1">1.44%</td></tr><tr><td align="left" rowspan="1" colspan="1">Second interventional group</td><td align="center" rowspan="1" colspan="1">44–91</td><td align="center" rowspan="1" colspan="1">77.15</td><td align="center" rowspan="1" colspan="1">1.11%</td></tr><tr><td align="center" colspan="5" rowspan="1"><hr></hr></td></tr><tr><td align="left" rowspan="3" colspan="1">Fev1% in % predicted</td><td align="left" rowspan="1" colspan="1">Edentulous subjects (control group)</td><td align="center" rowspan="1" colspan="1">59–114</td><td align="center" rowspan="1" colspan="1">94.40</td><td align="center" rowspan="1" colspan="1">0%</td></tr><tr><td align="left" rowspan="1" colspan="1">First interventional group</td><td align="center" rowspan="1" colspan="1">62–111</td><td align="center" rowspan="1" colspan="1">94.80</td><td align="center" rowspan="1" colspan="1">0.42%</td></tr><tr><td align="left" rowspan="1" colspan="1">Second interventional group</td><td align="center" rowspan="1" colspan="1">64–111</td><td align="center" rowspan="1" colspan="1">94.80</td><td align="center" rowspan="1" colspan="1">0.42%</td></tr><tr><td align="center" colspan="5" rowspan="1"><hr></hr></td></tr><tr><td align="left" rowspan="3" colspan="1">PIFR in L/sec</td><td align="left" rowspan="1" colspan="1">Edentulous subjects (control group)</td><td align="center" rowspan="1" colspan="1">1.43–3.75</td><td align="center" rowspan="1" colspan="1">2.39</td><td align="center" rowspan="1" colspan="1">0%</td></tr><tr><td align="left" rowspan="1" colspan="1">First interventional group</td><td align="center" rowspan="1" colspan="1">1.51–4.84</td><td align="center" rowspan="1" colspan="1">2.93</td><td align="center" rowspan="1" colspan="1">22.59%</td></tr><tr><td align="left" rowspan="1" colspan="1">Second interventional group</td><td align="center" rowspan="1" colspan="1">1.54–5.24</td><td align="center" rowspan="1" colspan="1">3.29</td><td align="center" rowspan="1" colspan="1">37.65%</td></tr></tbody></table></table-wrap><table-wrap id="tab2" position="float"><label>Table 2</label><caption><p>Statistical analysis of cephalograph and spirometric values. </p></caption><table frame="hsides" rules="groups"><thead><tr><th align="left" rowspan="1" colspan="1"></th><th align="center" rowspan="1" colspan="1">One-way ANOVA<break></break> (<italic>P</italic> value)</th><th align="center" rowspan="1" colspan="1">Dunnett “<italic>D</italic>” test A = <italic>P</italic> value between control group and first interventional group B = <italic>P</italic> value between control group and second interventional group</th><th align="center" rowspan="1" colspan="1">Unpaired “<italic>t</italic>” test<break></break> (<italic>P</italic> value)</th></tr></thead><tbody><tr><td align="left" rowspan="1" colspan="1">Retropharyngeal space</td><td align="center" rowspan="1" colspan="1">0.000 *S</td><td align="center" rowspan="1" colspan="1">A = 0.007 S<break></break>B = 0.000 S</td><td align="center" rowspan="1" colspan="1">0.004 S</td></tr><tr><td align="left" rowspan="1" colspan="1">Posterior airway space</td><td align="center" rowspan="1" colspan="1">0.000 S</td><td align="center" rowspan="1" colspan="1">A = 0.042 S<break></break>B = 0.000 S</td><td align="center" rowspan="1" colspan="1">0.015 S</td></tr><tr><td align="left" rowspan="1" colspan="1">apw2-ppw2</td><td align="center" rowspan="1" colspan="1">0.000 S</td><td align="center" rowspan="1" colspan="1"> A = 0.016 S<break></break>B = 0.000 S</td><td align="center" rowspan="1" colspan="1">0.002 S</td></tr><tr><td align="left" rowspan="1" colspan="1">apw4-ppw4</td><td align="center" rowspan="1" colspan="1">0.001 S</td><td align="center" rowspan="1" colspan="1">A = 0.103 NS<break></break>B = 0.000 S</td><td align="center" rowspan="1" colspan="1">0.099 NS</td></tr><tr><td align="left" rowspan="1" colspan="1">FVC</td><td align="center" rowspan="1" colspan="1">0.335 **NS</td><td align="center" rowspan="1" colspan="1">A = 0.862 NS<break></break>B = 0.628 NS</td><td align="center" rowspan="1" colspan="1">0.769 NS</td></tr><tr><td align="left" rowspan="1" colspan="1">Fev1</td><td align="center" rowspan="1" colspan="1">0.775 NS</td><td align="center" rowspan="1" colspan="1">A = 0.762 NS<break></break>B = 0.760 NS</td><td align="center" rowspan="1" colspan="1">0.998 NS</td></tr><tr><td align="left" rowspan="1" colspan="1">Fev1%</td><td align="center" rowspan="1" colspan="1">0.889 NS</td><td align="center" rowspan="1" colspan="1">A = 0.921 NS<break></break>B = 0.853 NS</td><td align="center" rowspan="1" colspan="1">0.914 NS</td></tr><tr><td align="left" rowspan="1" colspan="1">PIFR</td><td align="center" rowspan="1" colspan="1">0.000 S</td><td align="center" rowspan="1" colspan="1">A = 0.002 S<break></break>B = 0.000 S</td><td align="center" rowspan="1" colspan="1">0.031 S</td></tr></tbody></table><table-wrap-foot><fn><p>*S = significant.</p></fn><fn><p>**NS = non 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