Predictability of bone density at posterior mandibular implant sites using cone-beam computed tomography intensity values
Identifieur interne : 002C31 ( Pmc/Corpus ); précédent : 002C30; suivant : 002C32Predictability of bone density at posterior mandibular implant sites using cone-beam computed tomography intensity values
Auteurs : Mustafa Alkhader ; Malik Hudieb ; Yousef KhaderSource :
- European Journal of Dentistry [ 1305-7456 ] ; 2017.
Abstract
The aim of this study was to investigate the predictability of bone density at posterior mandibular implant sites using cone-beam computed tomography (CBCT) intensity values.
CBCT cross-sectional images for 436 posterior mandibular implant sites were selected for the study. Using Invivo software (Anatomage, San Jose, California, USA), two observers classified the bone density into three categories: low, intermediate, and high, and CBCT intensity values were generated.
Based on the consensus of the two observers, 15.6% of sites were of low bone density, 47.9% were of intermediate density, and 36.5% were of high density. Receiver-operating characteristic analysis showed that CBCT intensity values had a high predictive power for predicting high density sites (area under the curve [AUC] =0.94,
CBCT intensity values are considered useful for predicting bone density at posterior mandibular implant sites.
Url:
DOI: 10.4103/ejd.ejd_14_17
PubMed: 28932139
PubMed Central: 5594958
Links to Exploration step
PMC:5594958Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Predictability of bone density at posterior mandibular implant sites using cone-beam computed tomography intensity values</title><author><name sortKey="Alkhader, Mustafa" sort="Alkhader, Mustafa" uniqKey="Alkhader M" first="Mustafa" last="Alkhader">Mustafa Alkhader</name><affiliation><nlm:aff id="aff1">Department of Oral Surgery and Medicine, Faculty of Dentistry, Jordan University of Science and Technology, Irbid, Jordan</nlm:aff></affiliation></author><author><name sortKey="Hudieb, Malik" sort="Hudieb, Malik" uniqKey="Hudieb M" first="Malik" last="Hudieb">Malik Hudieb</name><affiliation><nlm:aff id="aff2">Department of Preventive Dentistry, Faculty of Dentistry, Jordan University of Science and Technology, Irbid, Jordan</nlm:aff></affiliation></author><author><name sortKey="Khader, Yousef" sort="Khader, Yousef" uniqKey="Khader Y" first="Yousef" last="Khader">Yousef Khader</name><affiliation><nlm:aff id="aff3">Department of Community Medicine, Public Health and Family Medicine, Faculty of Medicine, Jordan University of Science and Technology, Irbid, Jordan</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">28932139</idno><idno type="pmc">5594958</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5594958</idno><idno type="RBID">PMC:5594958</idno><idno type="doi">10.4103/ejd.ejd_14_17</idno><date when="2017">2017</date><idno type="wicri:Area/Pmc/Corpus">002C31</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002C31</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Predictability of bone density at posterior mandibular implant sites using cone-beam computed tomography intensity values</title><author><name sortKey="Alkhader, Mustafa" sort="Alkhader, Mustafa" uniqKey="Alkhader M" first="Mustafa" last="Alkhader">Mustafa Alkhader</name><affiliation><nlm:aff id="aff1">Department of Oral Surgery and Medicine, Faculty of Dentistry, Jordan University of Science and Technology, Irbid, Jordan</nlm:aff></affiliation></author><author><name sortKey="Hudieb, Malik" sort="Hudieb, Malik" uniqKey="Hudieb M" first="Malik" last="Hudieb">Malik Hudieb</name><affiliation><nlm:aff id="aff2">Department of Preventive Dentistry, Faculty of Dentistry, Jordan University of Science and Technology, Irbid, Jordan</nlm:aff></affiliation></author><author><name sortKey="Khader, Yousef" sort="Khader, Yousef" uniqKey="Khader Y" first="Yousef" last="Khader">Yousef Khader</name><affiliation><nlm:aff id="aff3">Department of Community Medicine, Public Health and Family Medicine, Faculty of Medicine, Jordan University of Science and Technology, Irbid, Jordan</nlm:aff></affiliation></author></analytic><series><title level="j">European Journal of Dentistry</title><idno type="ISSN">1305-7456</idno><idno type="eISSN">1305-7464</idno><imprint><date when="2017">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="st1"><title>Objective:</title><p>The aim of this study was to investigate the predictability of bone density at posterior mandibular implant sites using cone-beam computed tomography (CBCT) intensity values.</p></sec><sec id="st2"><title>Materials and Methods:</title><p>CBCT cross-sectional images for 436 posterior mandibular implant sites were selected for the study. Using Invivo software (Anatomage, San Jose, California, USA), two observers classified the bone density into three categories: low, intermediate, and high, and CBCT intensity values were generated.</p></sec><sec id="st3"><title>Results:</title><p>Based on the consensus of the two observers, 15.6% of sites were of low bone density, 47.9% were of intermediate density, and 36.5% were of high density. Receiver-operating characteristic analysis showed that CBCT intensity values had a high predictive power for predicting high density sites (area under the curve [AUC] =0.94, <italic>P</italic> < 0.005) and intermediate density sites (AUC = 0.81, <italic>P</italic> < 0.005). The best cut-off value for intensity to predict intermediate density sites was 218 (sensitivity = 0.77 and specificity = 0.76) and the best cut-off value for intensity to predict high density sites was 403 (sensitivity = 0.93 and specificity = 0.77).</p></sec><sec id="st4"><title>Conclusions:</title><p>CBCT intensity values are considered useful for predicting bone density at posterior mandibular implant sites.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Hanif, A" uniqKey="Hanif A">A Hanif</name></author><author><name sortKey="Qureshi, S" uniqKey="Qureshi S">S Qureshi</name></author><author><name sortKey="Sheikh, Z" uniqKey="Sheikh Z">Z Sheikh</name></author><author><name sortKey="Rashid, H" uniqKey="Rashid H">H Rashid</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Swami, V" uniqKey="Swami V">V Swami</name></author><author><name sortKey="Vijayaraghavan, V" uniqKey="Vijayaraghavan V">V 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<front><journal-meta><journal-id journal-id-type="nlm-ta">Eur J Dent</journal-id><journal-id journal-id-type="iso-abbrev">Eur J Dent</journal-id><journal-id journal-id-type="publisher-id">EJD</journal-id><journal-title-group><journal-title>European Journal of Dentistry</journal-title></journal-title-group><issn pub-type="ppub">1305-7456</issn><issn pub-type="epub">1305-7464</issn><publisher><publisher-name>Medknow Publications & Media Pvt Ltd</publisher-name><publisher-loc>India</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">28932139</article-id><article-id pub-id-type="pmc">5594958</article-id><article-id pub-id-type="publisher-id">EJD-11-311</article-id><article-id pub-id-type="doi">10.4103/ejd.ejd_14_17</article-id><article-categories><subj-group subj-group-type="heading"><subject>Original Article</subject></subj-group></article-categories><title-group><article-title>Predictability of bone density at posterior mandibular implant sites using cone-beam computed tomography intensity values</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Alkhader</surname><given-names>Mustafa</given-names></name><xref ref-type="aff" rid="aff1">1</xref><xref ref-type="corresp" rid="cor1"></xref></contrib><contrib contrib-type="author"><name><surname>Hudieb</surname><given-names>Malik</given-names></name><xref ref-type="aff" rid="aff2">2</xref></contrib><contrib contrib-type="author"><name><surname>Khader</surname><given-names>Yousef</given-names></name><xref ref-type="aff" rid="aff3">3</xref></contrib></contrib-group><aff id="aff1"><label>1</label>Department of Oral Surgery and Medicine, Faculty of Dentistry, Jordan University of Science and Technology, Irbid, Jordan</aff><aff id="aff2"><label>2</label>Department of Preventive Dentistry, Faculty of Dentistry, Jordan University of Science and Technology, Irbid, Jordan</aff><aff id="aff3"><label>3</label>Department of Community Medicine, Public Health and Family Medicine, Faculty of Medicine, Jordan University of Science and Technology, Irbid, Jordan</aff><author-notes><corresp id="cor1"><bold>Correspondence:</bold> Dr. Mustafa Alkhader Email: <email xlink:href="mmalkhader@just.edu.jo">mmalkhader@just.edu.jo</email></corresp></author-notes><pub-date pub-type="ppub"><season>Jul-Sep</season><year>2017</year></pub-date><volume>11</volume><issue>3</issue><fpage>311</fpage><lpage>316</lpage><permissions><copyright-statement>Copyright: © 2017 European Journal of Dentistry</copyright-statement><copyright-year>2017</copyright-year><license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by-nc-sa/3.0"><license-p>This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.</license-p></license></permissions><abstract><sec id="st1"><title>Objective:</title><p>The aim of this study was to investigate the predictability of bone density at posterior mandibular implant sites using cone-beam computed tomography (CBCT) intensity values.</p></sec><sec id="st2"><title>Materials and Methods:</title><p>CBCT cross-sectional images for 436 posterior mandibular implant sites were selected for the study. Using Invivo software (Anatomage, San Jose, California, USA), two observers classified the bone density into three categories: low, intermediate, and high, and CBCT intensity values were generated.</p></sec><sec id="st3"><title>Results:</title><p>Based on the consensus of the two observers, 15.6% of sites were of low bone density, 47.9% were of intermediate density, and 36.5% were of high density. Receiver-operating characteristic analysis showed that CBCT intensity values had a high predictive power for predicting high density sites (area under the curve [AUC] =0.94, <italic>P</italic> < 0.005) and intermediate density sites (AUC = 0.81, <italic>P</italic> < 0.005). The best cut-off value for intensity to predict intermediate density sites was 218 (sensitivity = 0.77 and specificity = 0.76) and the best cut-off value for intensity to predict high density sites was 403 (sensitivity = 0.93 and specificity = 0.77).</p></sec><sec id="st4"><title>Conclusions:</title><p>CBCT intensity values are considered useful for predicting bone density at posterior mandibular implant sites.</p></sec></abstract><kwd-group><kwd>Bone density</kwd><kwd>cone-beam computed tomography</kwd><kwd>dental implants</kwd><kwd>predictability</kwd></kwd-group></article-meta></front><body><sec sec-type="intro" id="sec1-1"><title>INTRODUCTION</title><p>Since the introduction of osseointegration field by Branemark 1987, Restoring missing teeth with dental implants has become a predictable treatment option,[<xref rid="ref1" ref-type="bibr">1</xref>] by which function and esthetics can be restored successfully. From a clinical point of view, successful osseointegration is reflected by implant stability, which can be divided into primary and secondary stability. Primary stability is associated with the mechanical engagement of an implant with the surrounding bone by which micromotion is reduced, allowing for the biological process of osseointegration of regeneration and remodeling to achieve the secondary (biological) stability.[<xref rid="ref2" ref-type="bibr">2</xref>]</p><p>Several factors have been found to affect the primary stability of endosseous implants which can be classified into patient-related (like bone quality and quantity) and non-patient related factors (like implant design and surgical procedure). Regarding patient-related factors, available bone quality and quantity are considered prerequisite for successful and predictable implant treatment.[<xref rid="ref3" ref-type="bibr">3</xref>] While the available bone quantity is reflected by the dimensions of alveolar bone that will house the fixture part of the implant, bone quality has been described by the relative amount of cancellous and cortical portions and the density of the recipient site of the alveolar bone.</p><p>In addition to the positive association between bone density and implant stability,[<xref rid="ref4" ref-type="bibr">4</xref><xref rid="ref5" ref-type="bibr">5</xref><xref rid="ref6" ref-type="bibr">6</xref><xref rid="ref7" ref-type="bibr">7</xref>] bone density can affect implant healing time and can modify the surgical technique.[<xref rid="ref8" ref-type="bibr">8</xref>] Moreover, bone density evaluation in the periapical area of teeth has its importance in endodontics,[<xref rid="ref9" ref-type="bibr">9</xref>] and bone density evaluation at specific areas like the palate, can be helpful in locating placement sites for mini implants and orthodontic skeletal anchorage devices.[<xref rid="ref10" ref-type="bibr">10</xref>]</p><p>For objective assessment of bone density at implant sites, both computed tomography (CT) and cone-beam CT (CBCT) can be used, and good correlation was shown between CT numbers (Hounsfield unit [HU]) and CBCT gray values.[<xref rid="ref11" ref-type="bibr">11</xref>] Unlike CT, many factors can affect CBCT grey or intensity values like type of scanner, field of view, position, and scanning parameters.[<xref rid="ref12" ref-type="bibr">12</xref>] Calibration is needed to generate CBCT intensity values similar to CT HUs.[<xref rid="ref13" ref-type="bibr">13</xref>]</p><p>On the other hand, several classifications have been proposed for subjective bone density assessment.[<xref rid="ref14" ref-type="bibr">14</xref><xref rid="ref15" ref-type="bibr">15</xref><xref rid="ref16" ref-type="bibr">16</xref><xref rid="ref17" ref-type="bibr">17</xref>] In the recent study done by Rebaudi <italic>et al</italic>.,[<xref rid="ref17" ref-type="bibr">17</xref>] a novel method of classifying bone density in CT/micro-CT into hard, normal and soft was proposed and suggested to be used in combination with objective bone density analysis. Even in case of CBCT, objective assessment of the bone density should be added to subjective assessment due to limitations in subjective assessment.[<xref rid="ref18" ref-type="bibr">18</xref><xref rid="ref19" ref-type="bibr">19</xref><xref rid="ref20" ref-type="bibr">20</xref>]</p><p>Similar to the example of Rebaudi <italic>et al</italic>.,[<xref rid="ref17" ref-type="bibr">17</xref>] we classified bone density at implant sites into low, intermediate, and high in the current study. To the best of our knowledge, no study has investigated the predictability of these three categories of bone density using CBCT intensity values, thus validating the conduction of this study.</p></sec><sec sec-type="materials|methods" id="sec1-2"><title>MATERIALS AND METHODS</title><sec id="sec2-1"><title>Patients</title><p>In our retrospective study, images for all patients who underwent CBCT examination for dental implant treatment and other dental purposes at our dental radiology clinic were retrieved and evaluated between January 2011 and January 2016. Only cases with missing lower posterior teeth were included in the study. The number of cases included were 436 (160 premolars and 276 molars), from 210 patients (85 males and 125 females) with a mean patient age of 46 years. Cases with artifacts or pathology affecting bone density at implant sites were excluded from the study. In addition, we excluded cases in which we were not able to simulate placement of 4 mm × 10 mm dental implant. This study was approved by our institutional research board (no. 382/2016).</p></sec><sec id="sec2-2"><title>Cone-beam computed tomography examination</title><p>As a CBCT apparatus, KODAK 9500 Cone Beam 3D System (Carestream, Rochester, NY, USA) with flat panel detector was used. The imaging area of CBCT is a cylinder with a height of 15–20.6 cm and a diameter of 9–18 cm providing isotropic cubic voxels with sides approximating 0.2–0.3 mm. Only cases examined with 0.2 mm were included in the study. The exposure parameters were: 90 kV as a tube voltage, 10 mA as a tube current, and 10.8 s as an exposure time.</p><p>Examinations were performed by 360° rotation in the occlusal position with the patient standing and closing their teeth.</p></sec><sec id="sec2-3"><title>Images</title><p>One calibrated oral radiologist (MA) with 9 years of experience with CBCT and dental implants was responsible for determining the implant sites, subjectively classifying the bone density on cross-sectional images at proposed implant sites into: Low, intermediate, and high, generating CBCT intensity values based on this classification, then saving the images for a second evaluation after 1 month, and third evaluation by one calibrated oral implantologist (MH) with 9 years of experience on a separate occasion. When the two observers disagreed about bone density evaluation, they evaluated the images again, and a consensus was then reached by discussion.</p><p>For the subjective evaluation of bone density at the implant sites, the trabecular bone was considered low density if marrow spaces are filling most of the site, intermediate density if bone trabeculae are filling half of the site and high density if bone trabeculae are filling most of the site [Figures <xref ref-type="fig" rid="F1">1</xref>–<xref ref-type="fig" rid="F3">3</xref>].</p><fig id="F1" position="float"><label>Figure 1</label><caption><p>Cone-beam computed tomography section showing high dense trabecular bone at mandibular molar implant site</p></caption><graphic xlink:href="EJD-11-311-g001"></graphic></fig><fig id="F2" position="float"><label>Figure 2</label><caption><p>Cone-beam computed tomography section showing intermediate dense trabecular bone at mandibular premolar implant site</p></caption><graphic xlink:href="EJD-11-311-g002"></graphic></fig><fig id="F3" position="float"><label>Figure 3</label><caption><p>Cone-beam computed tomography section showing low dense trabecular bone at mandibular molar implant site</p></caption><graphic xlink:href="EJD-11-311-g003"></graphic></fig><p>Using InVivo software (Anatomage, San Jose, California, USA), arch section module was utilized for determining the implant sites, simulating implant placement and generating CBCT intensity values. For simulating implant placement; the distance measurement tool was used for drawing a 4 mm × 10 mm rectangle at the implant sites, then HU measurement tool was used to generate intensity values for the simulated implants. HU measurement tool showed 3 intensity values at each implant site (minimum, mean and maximum). However, we only considered the mean intensity value for analysis.</p><p>All images were evaluated on high definition liquid crystal display with installed Invivo software, and window settings were fixed for all cases.</p></sec><sec id="sec2-4"><title>Statistical analysis</title><p>Analysis of data was achieved through the Statistical Package for Social Sciences software (version 15; SPSS Inc., Chicago, IL, USA). Means and standard deviations (SDs) as well as percentages were used to describe data. The difference in intensity values between the low, intermediate, and high-density sites was analyzed using one-way ANOVA. Overall percent agreement and Kappa statistics were used to determine the measure of agreements in the subjective evaluation of bone density between the two observers. Receiver-operating characteristic (ROC) curve analyses were used to examine the overall predictive power, sensitivity and specificity, and corresponding cutoff points of CBCT intensity values. The overall performance of CBCT intensity values for predicting bone density was assessed by computing the area under the curve (AUC). The best cutoff points for CBCT intensity values were determined at the point on the curve where the sum of sensitivity and specificity was highest. A value of <italic>P</italic> < 0.05 was considered statistically significant.</p></sec></sec><sec sec-type="results" id="sec1-3"><title>RESULTS</title><p>The overall percent of agreement in subjective classification of bone density for the first observer over the two repeated occasions of evaluations was 66.5% [<xref ref-type="table" rid="T1">Table 1</xref>] with a moderate agreement between the two repeated evaluations (Kappa statistics = 0.50; <italic>P</italic> < 0.005). The overall percent of agreement between the two observers was 64.7% [<xref ref-type="table" rid="T2">Table 2</xref>] with a moderate agreement between the two observers (Kappa statistics = 0.47; <italic>P</italic> < 0.005).</p><table-wrap id="T1" position="float"><label>Table 1</label><caption><p>The overall agreement for the first observer between the two repeated occasions of measurements</p></caption><graphic xlink:href="EJD-11-311-g004"></graphic></table-wrap><table-wrap id="T2" position="float"><label>Table 2</label><caption><p>The overall agreement between the two observers</p></caption><graphic xlink:href="EJD-11-311-g005"></graphic></table-wrap><p>Based on the consensus of the two observers, 15.6% of sites were of low bone density, 47.9% were of intermediate density, and 36.5% were of high density. The means (SD) of intensity values were 172 (99.3) for those with low density, 307 (123.1) for intermediate density, and 645 (192.3) for high density (<italic>P</italic> < 0.05).</p><p>ROC analysis showed that CBCT intensity values had a high predictive power for predicting high density sites (AUC = 0.94, <italic>P</italic> < 0.005, <xref ref-type="fig" rid="F4">Figure 4</xref>) and intermediate density sites (AUC = 0.81, <italic>P</italic> < 0.005, <xref ref-type="fig" rid="F5">Figure 5</xref>). The best cutoff value for intensity to predict intermediate density sites was 218 (sensitivity = 0.77 and specificity = 0.76) and the best cutoff value for intensity to predict high density sites was 403 (sensitivity = 0.93 and specificity = 0.77).</p><fig id="F4" position="float"><label>Figure 4</label><caption><p>Receiver-operating characteristic curve for predicting high density implant sites</p></caption><graphic xlink:href="EJD-11-311-g006"></graphic></fig><fig id="F5" position="float"><label>Figure 5</label><caption><p>Receiver-operating characteristic curve for predicting intermediate density implant sites</p></caption><graphic xlink:href="EJD-11-311-g007"></graphic></fig></sec><sec sec-type="discussion" id="sec1-4"><title>DISCUSSION</title><p>The assessment of bone density at potential dental implant sites is considered of paramount significance presurgically since it affects locating the best implant site, implant site preparation technique, implant positions, and the success rate of the implants.[<xref rid="ref17" ref-type="bibr">17</xref><xref rid="ref21" ref-type="bibr">21</xref><xref rid="ref22" ref-type="bibr">22</xref><xref rid="ref23" ref-type="bibr">23</xref>] Therefore, several studies have been conducted for this task,[<xref rid="ref4" ref-type="bibr">4</xref><xref rid="ref5" ref-type="bibr">5</xref><xref rid="ref6" ref-type="bibr">6</xref><xref rid="ref7" ref-type="bibr">7</xref><xref rid="ref8" ref-type="bibr">8</xref><xref rid="ref17" ref-type="bibr">17</xref><xref rid="ref18" ref-type="bibr">18</xref><xref rid="ref19" ref-type="bibr">19</xref><xref rid="ref20" ref-type="bibr">20</xref>] and different results were revealed due to use of various scanners, softwares, and methods.</p><p>Among imaging modalities used for bone density assessment, CBCT has advantages over conventional CT due to high image resolution and low radiation dose,[<xref rid="ref24" ref-type="bibr">24</xref>] and an advantage over micro-CT, since it is being used clinically and not only for <italic>in vitro</italic> experiments. Moreover, CBCT showed comparable results to micro-CT in assessing grey level distribution in human mandible.[<xref rid="ref25" ref-type="bibr">25</xref>]</p><p>In this study, we evaluated bone density at posterior mandibular implant sites. Around half of the sites had intermediate density, and the remaining half had both of low and high-density type of bone. This shows the importance of site-specific evaluation as recommended in previous studies.[<xref rid="ref17" ref-type="bibr">17</xref><xref rid="ref20" ref-type="bibr">20</xref><xref rid="ref22" ref-type="bibr">22</xref><xref rid="ref26" ref-type="bibr">26</xref>]</p><p>The inclusion of only posterior mandibular implant sites allowed us to simulate placement of one of commonly used implant sizes for all cases, and to evaluate the density of crestal 10 mm of trabecular bone, which is the most important area for osseointegration.[<xref rid="ref27" ref-type="bibr">27</xref>] In addition, the alveolar ridge of posterior mandibular implant sites is vertically oriented, which enabled us to simulate placement of vertically oriented implants and to overcome the limitation of the software being used, in which it cannot simulate placement of tilted implants.</p><p>For the subjective assessment of bone density in the current study, the intra- and inter-observer agreement were moderate; this reveals the difficulty in subjective assessment, especially when the bone has low to intermediate or intermediate to high density. The difficulty in subjective assessment of bone density was also present in few previous studies,[<xref rid="ref8" ref-type="bibr">8</xref><xref rid="ref26" ref-type="bibr">26</xref><xref rid="ref28" ref-type="bibr">28</xref><xref rid="ref29" ref-type="bibr">29</xref>] which could partially be due to dependence of subjective assessment on observer experience.</p><p>To overcome the limitations and difficulties in subjective visual assessment of bone density, the use of an objective scale like the one suggested by Norton and Gamble,[<xref rid="ref28" ref-type="bibr">28</xref>] or Trisi and Rao[<xref rid="ref29" ref-type="bibr">29</xref>] is useful and would be more accurate. However, this cannot be applied to CBCT. Similarly, we investigated the usefulness of CBCT intensity values in predicting bone density, and the values had high power in prediction of different types of bone density.</p><p>In the previous study by de Oliveira <italic>et al</italic>.,[<xref rid="ref26" ref-type="bibr">26</xref>] they used the subjective classification of bone density suggested by Lekholm and Zarb,[<xref rid="ref15" ref-type="bibr">15</xref>] and they divided the bone into four types. Despite this, they had only three categories of HU; below 200 for Type 4, between 200 and 400 for Type 2 and 3, and more than 400 for denser bone (Type 1). Again, similarly to Norton and Gamble[<xref rid="ref28" ref-type="bibr">28</xref>] and Trisi and Rao,[<xref rid="ref29" ref-type="bibr">29</xref>] they had difficulty in the subjective differentiation, specifically between Type 2 and 3 of bone. Therefore, our classification of bone density into low, moderate, and high, would be easier and more flexible to apply than classifying the bone into four types. Interestingly, our results are in agreement with de Oliveira <italic>et al</italic>.,[<xref rid="ref26" ref-type="bibr">26</xref>] since our cutoff intensity values were 403 and 218 for high and intermediate dense bone, respectively. This might be due to the exclusion of cortical bone from density assessment. Nevertheless, this shows the usefulness and ability of CBCT to generate intensity values comparable with CT numbers.</p><p>In the present study, a difference of about 200 of CBCT intensity value was required to differentiate between one type of bone density and the consecutive type. This difference is close to what reported by Lee <italic>et al</italic>.,[<xref rid="ref30" ref-type="bibr">30</xref>] as they reported a difference of 180 of HU.</p><p>In contrast to other previous studies,[<xref rid="ref18" ref-type="bibr">18</xref><xref rid="ref20" ref-type="bibr">20</xref><xref rid="ref21" ref-type="bibr">21</xref><xref rid="ref26" ref-type="bibr">26</xref><xref rid="ref28" ref-type="bibr">28</xref>] we simulate placement of implants in the crestal 10 mm of the trabecular bone, without including the cortical bone. The inclusion of cortical bone will increase the mean intensity value and is one cause for the different results. Needless to say, the shape and/or size of region of interest, and the section being used for evaluation are other causes for different results.</p><p>Our study has some limitations which require mentioning. We used third party software for CBCT intensity values calculation; this affected the quality of the imported images and resulted in difficulty in subjective image evaluation. Moreover, we simulated placement of a specific size of implants, which may not necessarily represent a true clinical situation and other factors may affect the treatment plan. Finally, our results cannot be generalized unless same CBCT machine and same protocol is followed for obtaining CBCT intensity values.</p></sec><sec sec-type="conclusion" id="sec1-5"><title>CONCLUSION</title><p>In conclusion, CBCT intensity values can be used for predicting bone density at posterior mandibular implant sites.</p><sec id="sec2-5"><title>Financial support and sponsorship</title><p>Nil.</p></sec><sec id="sec2-6" sec-type="COI-statement"><title>Conflicts of interest</title><p>There are no conflicts of interest.</p></sec></sec></body><back><ack><title>Acknowledgment</title><p>We are thankful for the Deanship of Scientific Research in Jordan University of Science and Technology for their approval and support in conducting the research.</p></ack><ref-list><title>REFERENCES</title><ref id="ref1"><label>1</label><element-citation publication-type="journal"><person-group 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