A comparative evaluation of extraction socket preservation with demineralized freeze-dried bone allograft alone and along with platelet-rich fibrin: A clinical and radiographic study
Identifieur interne : 002B48 ( Pmc/Corpus ); précédent : 002B47; suivant : 002B49A comparative evaluation of extraction socket preservation with demineralized freeze-dried bone allograft alone and along with platelet-rich fibrin: A clinical and radiographic study
Auteurs : Dhaval J. Thakkar ; Neeraj C. Deshpande ; Deepak H. Dave ; Suraj D. NarayankarSource :
- Contemporary Clinical Dentistry [ 0976-237X ] ; 2016.
Abstract
To investigate clinically and radiographically, the bone fill in extraction sockets using demineralized freeze-dried bone allograft alone and along with platelet-rich fibrin (PRF).
A randomized controlled clinical trial was carried out on 36 nonrestorable single-rooted teeth sites. Sites were randomized into demineralized freeze-dried bone allograft (DFDBA) combined with PRF - test and DFDBA - control groups using a coin toss method. After the placement of graft material, collagen membrane was used to cover it. The clinical parameters recorded were ridge width and ridge height. All the parameters were recorded at baseline and at 90 and 180 days.
Independent
In both groups, there is significant reduction in loss of ridge width and ridge height from baseline to 90 days (
Although DFDBA is considered as an ideal graft material, PRF can be used as an adjunctive with DFDBA for socket preservation.
Url:
DOI: 10.4103/0976-237X.188567
PubMed: 27630503
PubMed Central: 5004552
Links to Exploration step
PMC:5004552Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">A comparative evaluation of extraction socket preservation with demineralized freeze-dried bone allograft alone and along with platelet-rich fibrin: A clinical and radiographic study</title><author><name sortKey="Thakkar, Dhaval J" sort="Thakkar, Dhaval J" uniqKey="Thakkar D" first="Dhaval J." last="Thakkar">Dhaval J. Thakkar</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Deshpande, Neeraj C" sort="Deshpande, Neeraj C" uniqKey="Deshpande N" first="Neeraj C." last="Deshpande">Neeraj C. Deshpande</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Dave, Deepak H" sort="Dave, Deepak H" uniqKey="Dave D" first="Deepak H." last="Dave">Deepak H. Dave</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Narayankar, Suraj D" sort="Narayankar, Suraj D" uniqKey="Narayankar S" first="Suraj D." last="Narayankar">Suraj D. Narayankar</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">27630503</idno><idno type="pmc">5004552</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5004552</idno><idno type="RBID">PMC:5004552</idno><idno type="doi">10.4103/0976-237X.188567</idno><date when="2016">2016</date><idno type="wicri:Area/Pmc/Corpus">002B48</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002B48</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">A comparative evaluation of extraction socket preservation with demineralized freeze-dried bone allograft alone and along with platelet-rich fibrin: A clinical and radiographic study</title><author><name sortKey="Thakkar, Dhaval J" sort="Thakkar, Dhaval J" uniqKey="Thakkar D" first="Dhaval J." last="Thakkar">Dhaval J. Thakkar</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Deshpande, Neeraj C" sort="Deshpande, Neeraj C" uniqKey="Deshpande N" first="Neeraj C." last="Deshpande">Neeraj C. Deshpande</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Dave, Deepak H" sort="Dave, Deepak H" uniqKey="Dave D" first="Deepak H." last="Dave">Deepak H. Dave</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Narayankar, Suraj D" sort="Narayankar, Suraj D" uniqKey="Narayankar S" first="Suraj D." last="Narayankar">Suraj D. Narayankar</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author></analytic><series><title level="j">Contemporary Clinical Dentistry</title><idno type="ISSN">0976-237X</idno><idno type="eISSN">0976-2361</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="st1"><title>Aims:</title><p>To investigate clinically and radiographically, the bone fill in extraction sockets using demineralized freeze-dried bone allograft alone and along with platelet-rich fibrin (PRF).</p></sec><sec id="st2"><title>Materials and Methods:</title><p>A randomized controlled clinical trial was carried out on 36 nonrestorable single-rooted teeth sites. Sites were randomized into demineralized freeze-dried bone allograft (DFDBA) combined with PRF - test and DFDBA - control groups using a coin toss method. After the placement of graft material, collagen membrane was used to cover it. The clinical parameters recorded were ridge width and ridge height. All the parameters were recorded at baseline and at 90 and 180 days.</p></sec><sec id="st3"><title>Statistical Analysis Used:</title><p>Independent <italic>t</italic>-test and paired <italic>t</italic>-test.</p></sec><sec id="st4"><title>Results:</title><p>In both groups, there is significant reduction in loss of ridge width and ridge height from baseline to 90 days (<italic>P</italic> < 0.001), baseline to 180 days (<italic>P</italic> < 0.001), and 90–180 days (<italic>P</italic> < 0.001). However, when both the groups were compared the test group favored in the reduction of ridge width while there was no statistical difference in reduction of ridge height among at different intervals.</p></sec><sec id="st5"><title>Conclusions:</title><p>Although DFDBA is considered as an ideal graft material, PRF can be used as an adjunctive with DFDBA for socket preservation.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Weng, D" uniqKey="Weng D">D Weng</name></author><author><name sortKey="Stock, V" uniqKey="Stock V">V Stock</name></author><author><name sortKey="Schliephake, H" uniqKey="Schliephake H">H Schliephake</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chan, Hl" uniqKey="Chan H">HL Chan</name></author><author><name sortKey="Lin, Gh" uniqKey="Lin G">GH Lin</name></author><author><name sortKey="Fu, Jh" uniqKey="Fu J">JH Fu</name></author><author><name sortKey="Wang, Hl" uniqKey="Wang H">HL Wang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Avila Ortiz, G" uniqKey="Avila Ortiz G">G Avila-Ortiz</name></author><author><name sortKey="Elangovan, S" uniqKey="Elangovan S">S Elangovan</name></author><author><name sortKey="Kramer, Kw" uniqKey="Kramer K">KW Kramer</name></author><author><name sortKey="Blanchette, D" uniqKey="Blanchette D">D Blanchette</name></author><author><name sortKey="Dawson, Dv" uniqKey="Dawson D">DV Dawson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kukreja, Bj" uniqKey="Kukreja B">BJ Kukreja</name></author><author><name sortKey="Dodwad, V" uniqKey="Dodwad V">V Dodwad</name></author><author><name sortKey="Kukreja, P" uniqKey="Kukreja P">P Kukreja</name></author><author><name sortKey="Ahuja, S" uniqKey="Ahuja S">S Ahuja</name></author><author><name sortKey="Mehra, P" uniqKey="Mehra P">P Mehra</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Naik, B" uniqKey="Naik B">B Naik</name></author><author><name sortKey="Karunakar, P" uniqKey="Karunakar P">P Karunakar</name></author><author><name sortKey="Jayadev, M" uniqKey="Jayadev M">M Jayadev</name></author><author><name sortKey="Marshal, Vr" uniqKey="Marshal V">VR Marshal</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zubillaga, G" uniqKey="Zubillaga G">G Zubillaga</name></author><author><name sortKey="Hagen, S" uniqKey="Hagen S">S Hagen</name></author><author><name sortKey="Simon, B" uniqKey="Simon B">B Simon</name></author><author><name sortKey="Deasy, M" uniqKey="Deasy M">M Deasy</name></author></analytic></biblStruct></listBibl></div1></back></TEI><pmc article-type="research-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Contemp Clin Dent</journal-id><journal-id journal-id-type="iso-abbrev">Contemp Clin Dent</journal-id><journal-id journal-id-type="publisher-id">CCD</journal-id><journal-title-group><journal-title>Contemporary Clinical Dentistry</journal-title></journal-title-group><issn pub-type="ppub">0976-237X</issn><issn pub-type="epub">0976-2361</issn><publisher><publisher-name>Medknow Publications & Media Pvt Ltd</publisher-name><publisher-loc>India</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">27630503</article-id><article-id pub-id-type="pmc">5004552</article-id><article-id pub-id-type="publisher-id">CCD-7-371</article-id><article-id pub-id-type="doi">10.4103/0976-237X.188567</article-id><article-categories><subj-group subj-group-type="heading"><subject>Original Article</subject></subj-group></article-categories><title-group><article-title>A comparative evaluation of extraction socket preservation with demineralized freeze-dried bone allograft alone and along with platelet-rich fibrin: A clinical and radiographic study</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Thakkar</surname><given-names>Dhaval J.</given-names></name><xref ref-type="aff" rid="aff1"></xref><xref ref-type="corresp" rid="cor1"></xref></contrib><contrib contrib-type="author"><name><surname>Deshpande</surname><given-names>Neeraj C.</given-names></name><xref ref-type="aff" rid="aff1"></xref></contrib><contrib contrib-type="author"><name><surname>Dave</surname><given-names>Deepak H.</given-names></name><xref ref-type="aff" rid="aff1"></xref></contrib><contrib contrib-type="author"><name><surname>Narayankar</surname><given-names>Suraj D.</given-names></name><xref ref-type="aff" rid="aff1"></xref></contrib></contrib-group><aff id="aff1"><italic>Department of Periodontics, K.M. Shah Dental College and Hospital, Sumandeep Vidyapeeth, Vadodara, Gujarat, India</italic></aff><author-notes><corresp id="cor1"><bold>Correspondence:</bold> Dr. Dhaval J. Thakkar, D-68, Sundarvan Society, Near Suvas Park, Vadodara - 390 024, Gujarat, India. E-mail: <email xlink:href="dhaval9@hotmail.com">dhaval9@hotmail.com</email></corresp></author-notes><pub-date pub-type="ppub"><season>Jul-Sep</season><year>2016</year></pub-date><volume>7</volume><issue>3</issue><fpage>371</fpage><lpage>376</lpage><permissions><copyright-statement>Copyright: © Contemporary Clinical Dentistry</copyright-statement><copyright-year>2016</copyright-year><license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by-nc-sa/3.0"><license-p>This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.</license-p></license></permissions><abstract><sec id="st1"><title>Aims:</title><p>To investigate clinically and radiographically, the bone fill in extraction sockets using demineralized freeze-dried bone allograft alone and along with platelet-rich fibrin (PRF).</p></sec><sec id="st2"><title>Materials and Methods:</title><p>A randomized controlled clinical trial was carried out on 36 nonrestorable single-rooted teeth sites. Sites were randomized into demineralized freeze-dried bone allograft (DFDBA) combined with PRF - test and DFDBA - control groups using a coin toss method. After the placement of graft material, collagen membrane was used to cover it. The clinical parameters recorded were ridge width and ridge height. All the parameters were recorded at baseline and at 90 and 180 days.</p></sec><sec id="st3"><title>Statistical Analysis Used:</title><p>Independent <italic>t</italic>-test and paired <italic>t</italic>-test.</p></sec><sec id="st4"><title>Results:</title><p>In both groups, there is significant reduction in loss of ridge width and ridge height from baseline to 90 days (<italic>P</italic> < 0.001), baseline to 180 days (<italic>P</italic> < 0.001), and 90–180 days (<italic>P</italic> < 0.001). However, when both the groups were compared the test group favored in the reduction of ridge width while there was no statistical difference in reduction of ridge height among at different intervals.</p></sec><sec id="st5"><title>Conclusions:</title><p>Although DFDBA is considered as an ideal graft material, PRF can be used as an adjunctive with DFDBA for socket preservation.</p></sec></abstract><kwd-group><title>Key words</title><kwd>Atraumatic extraction</kwd><kwd>collagen</kwd><kwd>demineralized freeze-dried bone allograft</kwd><kwd>platelet-rich fibrin</kwd><kwd>socket preservation</kwd></kwd-group></article-meta></front><body><sec sec-type="intro" id="sec1-1"><title>Introduction</title><p>Socket preservation is a procedure to preserve hard and soft tissue of the alveolar ridge after extraction. The alveolar process is a tooth-dependent structure, so after the extraction bone loss occurs very rapidly in the initial 6 months, results into the reduction of 40% of alveolar height, and 60% of alveolar width. Various evidence has proved that the bone loss occurs after extraction and more at the labial side of the alveolar process compared to the lingual or the palatal side.[<xref rid="ref1" ref-type="bibr">1</xref>]</p><p>A clinical study on 46 patients evaluated bone healing and soft tissue contour changes after tooth removal. They found an approximate 50% reduction in the buccolingual width of edentulous sites after 12 months. Therefore, it was concluded that it is a mandatory to preserve the dimensions of the tooth socket after extraction, especially if an osseointegrated implant is planned. There are many studies that showed beneficial effects of using different grafts, membrane, and various growth factors to preserve the sockets compared to sockets which are left untreated.[<xref rid="ref2" ref-type="bibr">2</xref>] Therefore, the aim was to investigate the bone fill in extraction sockets using demineralized freeze-dried bone allograft alone and along with platelet-rich fibrin (PRF), clinically and radiographically.</p></sec><sec sec-type="materials|methods" id="sec1-2"><title>Materials and Methods</title><p>A randomized controlled, clinical, radiographic study was planned after due Ethical Approval from Institutional Ethics Committee of Sumandeep Vidyapeeth was obtained. Patients who came to the Department of Periodontology from January 2014 to January 2015, for the treatment of a single-rooted, nonrestorable, or hopeless tooth having adjacent teeth were included in this study. Written informed consent was obtained from the participants.</p><p>Patients between the age group of 20 and 55 years, requiring extraction of at least one maxillary or mandibular nonrestorable single-rooted tooth were included in the study. Patients with <50% bone loss, uncontrolled systemic disease, severe parafunctional habits, poor maintenance of oral hygiene, pregnancy, smokers, or taking any medications that could compromise healing were excluded from the study. A total of 36 single-rooted teeth in maxillary and mandibular arches, indicated for extraction were included in the study. Scaling and root planning were performed before the procedure, and oral hygiene instruction was given. Any periodontal treatment necessary to provide an oral environment more favorable to wound healing was done. Surgical acrylic resin stents were fabricated using dental casts of all the patients.</p><p>Pearson Chi-square test was done to evaluate demographic data. In control group, females were 38.9% and 61.1% male participants and in test group, females were 44.4% and 55.6% male participants. No significant statistical difference was found among the groups that justified, both groups were similar (<italic>P</italic> = 0.73).</p><sec id="sec2-1"><title>Surgical procedure</title><p>Before surgery, alveolar ridge width was calculated with the help of Vernier caliper and calibrated radiographs were made with the help of grid. After anesthetizing the surgical area, it was ensured that minimum trauma was caused while extracting the teeth as shown in Figure <xref ref-type="fig" rid="F1">1a</xref> and <xref ref-type="fig" rid="F1">b</xref> (test site) and Figure <xref ref-type="fig" rid="F2">2a</xref> and <xref ref-type="fig" rid="F2">b</xref> (control site). Periotomes and forceps were used with great care taken to maintain the buccal bone and the surrounding soft and hard tissues. Following atraumatic extraction, the height of the buccal and lingual bone plate was clinically examined at the mid buccal and mid lingual region with help of a periodontal probe as well as the height of the socket was measured till the base which helped to measure the amount of vertical bone loss on buccal plate as compared to the lingual plate.</p><fig id="F1" position="float"><label>Figure 1</label><caption><p>(a) Preoperative test site. (b) Extraction socket test group</p></caption><graphic xlink:href="CCD-7-371-g001"></graphic></fig><fig id="F2" position="float"><label>Figure 2</label><caption><p>(a) Preoperative control site. (b) Immediate extraction socket control site</p></caption><graphic xlink:href="CCD-7-371-g002"></graphic></fig><p>Following extraction, granulation tissues were removed with the help of curettes, and the socket was irrigated with sterile normal saline. Computer-generated randomization was used to randomly divide the sockets into two groups.</p><p>In test group - demineralized freeze-dried bone allograft (DFDBA) mixed with PRF was condensed into the extraction sockets until the crestal level, and a collagen membrane was used to cover the graft material and in control group - DFDBA was condensed into the extraction socket until the crestal level and similarly, collagen membrane was used to cover the wound.</p><p>PRF was prepared by collecting patient's blood from the median cubital vein using a 10 ml syringe and centrifuged at 3000 rpm for 10 min. Blood centrifugation leads to the formation of a fibrin clot that immediately transferred into the socket.</p><p>In both groups, the flaps were sutured with criss-cross horizontal mattress technique, to cover as much as possible of the biomaterials. The postoperative instruction was given, and participants were recalled at an interval of 90 and 180 days and calibrated radiographs as shown in Figure <xref ref-type="fig" rid="F3">3a</xref>–<xref ref-type="fig" rid="F3">c</xref> (In test group) and Figure <xref ref-type="fig" rid="F4">4a</xref>–<xref ref-type="fig" rid="F4">c</xref> (In control group) with the help of grid, and clinical measurements were recorded.</p><fig id="F3" position="float"><label>Figure 3</label><caption><p>(a) Immediate X-ray test site. (b) Test site X-ray -90 days. (c) Test site X-ray -180 days</p></caption><graphic xlink:href="CCD-7-371-g003"></graphic></fig><fig id="F4" position="float"><label>Figure 4</label><caption><p>(a) Immediate X-ray control site. (b) Control site X-ray -90 days. (c) Control site X-ray -180 days</p></caption><graphic xlink:href="CCD-7-371-g004"></graphic></fig></sec></sec><sec sec-type="results" id="sec1-3"><title>Results</title><p>A total of 36 sites were treated, and independent <italic>t</italic>-test was performed to compare the parameters between the two groups and paired <italic>t</italic>-test was performed to compare the parameter within the same group. The independent <italic>t</italic>-test was performed to compare ridge width and ridge height at baseline, 90, and 180 days.</p><p>Analysis and comparison of the difference between ridge width and ridge height at different intervals that is baseline, 90, and 180 days were done, and this was facilitated in three pairs each for ridge width and height that is from baseline to 90 days, baseline to 180 days, and 90 to 180 days for the control group. All the results were obtained with <italic>P</italic> < 0.001 and 95% of confidence interval (CI) and were found to be statistically significant within all pairs thus justifying that there is a significant reduction in loss of ridge width and height at regular intervals for control group [Tables <xref ref-type="table" rid="T1">1</xref> and <xref ref-type="table" rid="T2">2</xref>].</p><table-wrap id="T1" position="float"><label>Table 1</label><caption><p>Clinical parameters of demineralized freeze-dried bone allograft group at baseline, at 90 days, and at 180 days</p></caption><graphic xlink:href="CCD-7-371-g005"></graphic></table-wrap><table-wrap id="T2" position="float"><label>Table 2</label><caption><p>Difference of clinical parameters of demineralized freeze-dried bone allograft group at baseline, at 90 days, and at 180 days</p></caption><graphic xlink:href="CCD-7-371-g006"></graphic></table-wrap><p>Analysis and comparison of the difference between ridge width and ridge height at different intervals that is baseline, 90, and 180 days was done, and this was facilitated in three pairs each for ridge width and height that is, from baseline to 90 days, baseline to 180 days, and 90 to 180 days for the test group. All the results were obtained with <italic>P</italic> < 0.001 and 95% of CI and were found to be statistically significant within all pairs thus justifying that there is a significant reduction in loss of ridge width and height at regular intervals. Thus, DFDBA combined with PRF can be used as a graft material to prevent the loss of ridge width and ridge height [Tables <xref ref-type="table" rid="T3">3</xref> and <xref ref-type="table" rid="T4">4</xref>].</p><table-wrap id="T3" position="float"><label>Table 3</label><caption><p>Clinical parameters of demineralized freeze-dried bone allograft+platelet rich fibrin group at baseline, at 90 days, and at 180 days (mean±standard deviation)</p></caption><graphic xlink:href="CCD-7-371-g007"></graphic></table-wrap><table-wrap id="T4" position="float"><label>Table 4</label><caption><p>Difference of clinical parameters of demineralized freeze-dried bone allograft+platelet rich fibrin group at baseline, at 90 days, and at 180 days</p></caption><graphic xlink:href="CCD-7-371-g008"></graphic></table-wrap><p>The difference of ridge width and ridge height between the test and the control group are calculated, and the results interpret that in the test group there is loss of 0.75 mm of ridge width while there was loss of 1.36 mm in control group. In control group, 1.36 mm of ridge height was lost, and 1.08 mm was lost in test group. Thus seeing the results, it was proved that using DFDBA combined with PRF had an additional benefit in preserving ridge width better than using DFDBA alone with <italic>P</italic> < 0.001. Both groups helped to minimize the loss of ridge height, but on comparing both groups, there was no significant statistical difference between groups for ridge height [Tables <xref ref-type="table" rid="T5">5</xref> and <xref ref-type="table" rid="T6">6</xref>].</p><table-wrap id="T5" position="float"><label>Table 5</label><caption><p>Ridge width and height difference at baseline and at 180 days between demineralized freeze-dried bone allograft group and demineralized freeze-dried bone allograft+platelet rich fibrin</p></caption><graphic xlink:href="CCD-7-371-g009"></graphic></table-wrap><table-wrap id="T6" position="float"><label>Table 6</label><caption><p>Difference of clinical parameters between test and control groups</p></caption><graphic xlink:href="CCD-7-371-g010"></graphic></table-wrap></sec><sec sec-type="discussion" id="sec1-4"><title>Discussion</title><p>To achieve a predictable esthetic and functional restoration, it is important to preserve the dimension of alveolar ridge width and height after tooth extraction. Following extraction of tooth various patterns of bone resorption, especially on buccal side, can occur therefore socket preservation plays a very crucial role. Therefore, to preserve the maximum amount of ridge atraumatic extraction was performed which focus on gently severing the periodontal attachment using micro-instrumentation.</p><p>Alveolar ridge preservation is a surgical procedure which retains maximum bone and soft tissue after the extraction of tooth is done. The advantage of this procedure is that it maintains the original ridge morphology. Therefore, there will be minimal need for grafting the socket allowing the final restoration to be placed in an esthetic and functional position.[<xref rid="ref3" ref-type="bibr">3</xref>]</p><p>A total of 36 nonrestorable single-rooted teeth were extracted in maxilla or mandible, and sockets preserved with DFDBA combined with PRF were compared with DFDBA alone and dimensional changes were evaluated at 90 and 180 days. In this study at baseline, at 90 days and at 180 days, standardized intraoral periapical radiographs were recorded. The levels of the alveolar bone crest were measured from the most coronal point of the adjacent tooth till the alveolar crest. The type of film, exposure time, processing of film, and radiographic equipment were all standardized.</p><p>DFDBA has been widely used in periodontal therapy and is proven to be safe, and it can induce the formation of new bone. DFDBA has both properties osteoconductive and osteoinductive. Use of DFDBA in various animal studies has proved that it could stimulate the formation of new bone by osteoinduction. It stimulates the host undifferentiated mesenchymal cells to differentiate into osteoblasts and lead to bone formation. DFDBA also acts as a scaffold for osteoconduction.[<xref rid="ref4" ref-type="bibr">4</xref>] As DFDBA fulfills the criteria of an ideal graft material so in this study, it is used in both the groups.</p><p>PRF is an autologous source, and it contains various growth factors such as platelet-derived growth factors and insulin-like growth factors. Growth factors are a class of natural biologic mediators that regulate key cellular events in tissue regeneration including cell proliferation, chemotaxis, differentiation, and matrix synthesis via binding to specific cell surface receptors and is also found to enhance healing.[<xref rid="ref5" ref-type="bibr">5</xref>]</p><p>The nature of extraction socket is such that it can cause the loss of the majority of bone graft. Therefore, to avoid the loss of graft material, the use of collagen membrane was used not only to avoid the loss of graft material but also induce stabilize wound and promote blood clot formation. Among all the available membrane collagen membrane was preferred due to its high biocompatibility and hemostatic activity that can facilitate clot formation and would stabilization. Collagen also has a high chemotactic function for fibroblasts. This promotes cell migration, and primary wound coverage maximum efforts were made to achieve complete coverage of membrane, but complete coverage was not obtained in all cases.[<xref rid="ref6" ref-type="bibr">6</xref>] In a study done by Nam and Park in 2009 showed that if membrane exposure occurs during the healing phase, it does not affect the outcome of ridge preservation. In the present study not a single exposure of membrane occurred. Uneventful healing was noted in all the cases.</p><p>While comparing the results of both test and control groups from baseline to 90 days showed statistical significant improvement in all the parameters. Similar improvement was noted for both the groups from baseline to 180 days. However, statistically significant improvement was noted in respect to width from baseline to 180 days in both the groups. This is consistent with the earlier studies done using DFDBA alone for the purpose of socket preservation. The use of PRF along with DFDBA has significant advantages over the use of DFDBA alone. Use of PRF aids in retaining of the bone graft material within the walls of the socket, as it is a fibrin clot, it aids in the arrest of bleeding as well.</p><p>All the patients completed the study, and the planned surgical procedures were completed without any complications. The postsurgical phase of healing was uneventful with few patients reporting pain.</p><p>However, despite all attempts being made to carry out a study which considers all the required parameters, following some limitations does exist in this study as well. In this study, intraoral radiographic technique was used to measure the bone width and height changes. However, the use of cone beam computed tomography could have been done to achieve more accurate results. Several studies have carried out histomorphometric analysis which was not done in this study. Placement of implants was not done at the follow-up and hence, histological analysis could not be done. In this study, a manual Vernier caliper was used to measure clinical dimensions. However, a digital Vernier caliper could have been used in hindsight. The width of keratinized gingiva could also have been measured in this study.</p></sec><sec sec-type="conclusions" id="sec1-5"><title>Conclusion</title><p>Irrespective of the reasons for socket preservation, sufficient alveolar ridge width and height are essential to meet the functional and esthetic demand of the patient. The results of this study showed significant reduction in ridge width and height for both groups at 90 and 180 days. when both groups were compared PRF combined with DFDBA preserved ridge width better than DFDBA alone. 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