Treatment Alternatives to Negotiate Peri-Implantitis
Identifieur interne : 002809 ( Pmc/Corpus ); précédent : 002808; suivant : 002810Treatment Alternatives to Negotiate Peri-Implantitis
Auteurs : Eli E. MachteiSource :
- Advances in Medicine [ 2356-6752 ] ; 2014.
Abstract
Peri-implant diseases are becoming a major health issue in dentistry. Despite the magnitude of this problem and the potential grave consequences, commonly acceptable treatment protocols are missing. Hence, the present paper reviews the literature treatment of peri-implantitis in order to explore their benefits and limitations. Treatment of peri-implantitis may include surgical and nonsurgical approaches, either individually or combined. Nonsurgical therapy is aimed at removing local irritants from the implants' surface with or without surface decontamination and possibly some additional adjunctive therapies agents or devices. Systemic antibiotics may also be incorporated. Surgical therapy is aimed at removing any residual subgingival deposits and additionally reducing the peri-implant pockets depth. This can be done alone or in conjunction with either osseous respective approach or regenerative approach. Finally, if all fails, explantation might be the best alternative in order to arrest the destruction of the osseous structure around the implant, thus preserving whatever is left in this site for future reconstruction. The available literature is still lacking with large heterogeneity in the clinical response thus suggesting possible underlying predisposing conditions that are not all clear to us. Therefore, at present time treatment of peri-implantitis should be considered possible but not necessarily predictable.
Url:
DOI: 10.1155/2014/487903
PubMed: 26556414
PubMed Central: 4590969
Links to Exploration step
PMC:4590969Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Treatment Alternatives to Negotiate Peri-Implantitis</title><author><name sortKey="Machtei, Eli E" sort="Machtei, Eli E" uniqKey="Machtei E" first="Eli E." last="Machtei">Eli E. Machtei</name><affiliation><nlm:aff id="I1"> Department of Periodontology, School of Graduate Dentistry, Rambam Health Care Campus and Faculty of Medicine, Technion (Israel Institute of Technology), Rambam HCC, 8 Ha'alia Hashnia Street, 31096 Haifa, Israel</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">26556414</idno><idno type="pmc">4590969</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4590969</idno><idno type="RBID">PMC:4590969</idno><idno type="doi">10.1155/2014/487903</idno><date when="2014">2014</date><idno type="wicri:Area/Pmc/Corpus">002809</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002809</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Treatment Alternatives to Negotiate Peri-Implantitis</title><author><name sortKey="Machtei, Eli E" sort="Machtei, Eli E" uniqKey="Machtei E" first="Eli E." last="Machtei">Eli E. Machtei</name><affiliation><nlm:aff id="I1"> Department of Periodontology, School of Graduate Dentistry, Rambam Health Care Campus and Faculty of Medicine, Technion (Israel Institute of Technology), Rambam HCC, 8 Ha'alia Hashnia Street, 31096 Haifa, Israel</nlm:aff></affiliation></author></analytic><series><title level="j">Advances in Medicine</title><idno type="ISSN">2356-6752</idno><idno type="eISSN">2314-758X</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Peri-implant diseases are becoming a major health issue in dentistry. Despite the magnitude of this problem and the potential grave consequences, commonly acceptable treatment protocols are missing. Hence, the present paper reviews the literature treatment of peri-implantitis in order to explore their benefits and limitations. Treatment of peri-implantitis may include surgical and nonsurgical approaches, either individually or combined. Nonsurgical therapy is aimed at removing local irritants from the implants' surface with or without surface decontamination and possibly some additional adjunctive therapies agents or devices. Systemic antibiotics may also be incorporated. Surgical therapy is aimed at removing any residual subgingival deposits and additionally reducing the peri-implant pockets depth. This can be done alone or in conjunction with either osseous respective approach or regenerative approach. Finally, if all fails, explantation might be the best alternative in order to arrest the destruction of the osseous structure around the implant, thus preserving whatever is left in this site for future reconstruction. The available literature is still lacking with large heterogeneity in the clinical response thus suggesting possible underlying predisposing conditions that are not all clear to us. Therefore, at present time treatment of peri-implantitis should be considered possible but not necessarily predictable.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Zitzmann, N U" uniqKey="Zitzmann N">N. U. Zitzmann</name></author><author><name sortKey="Berglundh, T" uniqKey="Berglundh T">T. Berglundh</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mombelli, A" uniqKey="Mombelli A">A. Mombelli</name></author><author><name sortKey="Muller, N" uniqKey="Muller N">N. Müller</name></author><author><name sortKey="Cionca, N" uniqKey="Cionca N">N. Cionca</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Atieh, M A" uniqKey="Atieh M">M. A. Atieh</name></author><author><name sortKey="Alsabeeha, N H" uniqKey="Alsabeeha N">N. H. Alsabeeha</name></author><author><name sortKey="Faggion, C M" uniqKey="Faggion C">C. M. Faggion</name></author><author><name sortKey="Duncan, W J" uniqKey="Duncan W">W. J. Duncan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rinke, S" uniqKey="Rinke S">S. Rinke</name></author><author><name sortKey="Ohl, S" uniqKey="Ohl S">S. Ohl</name></author><author><name sortKey="Ziebolz, D" uniqKey="Ziebolz D">D. Ziebolz</name></author><author><name sortKey="Lange, K" uniqKey="Lange K">K. Lange</name></author><author><name sortKey="Eickholz, P" uniqKey="Eickholz P">P. Eickholz</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rodriguez Argueta, O F" uniqKey="Rodriguez Argueta O">O. F. Rodriguez-Argueta</name></author><author><name sortKey="Figueiredo, R" uniqKey="Figueiredo R">R. Figueiredo</name></author><author><name sortKey="Valmaseda Castellon, E" uniqKey="Valmaseda Castellon E">E. Valmaseda-Castellon</name></author><author><name sortKey="Gay Escoda, C" uniqKey="Gay Escoda C">C. Gay-Escoda</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cho Yan Lee, J" uniqKey="Cho Yan Lee J">J. Cho-Yan Lee</name></author><author><name sortKey="Mattheos, N" uniqKey="Mattheos N">N. Mattheos</name></author><author><name sortKey="Nixon, K C" uniqKey="Nixon K">K. C. Nixon</name></author><author><name sortKey="Ivanovski, S" uniqKey="Ivanovski S">S. Ivanovski</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Roccuzzo, M" uniqKey="Roccuzzo M">M. Roccuzzo</name></author><author><name sortKey="Bonino, F" uniqKey="Bonino F">F. Bonino</name></author><author><name sortKey="Aglietta, M" uniqKey="Aglietta M">M. Aglietta</name></author><author><name sortKey="Dalmasso, P" uniqKey="Dalmasso P">P. Dalmasso</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Carcuac, O" uniqKey="Carcuac O">O. Carcuac</name></author><author><name sortKey="Jansson, L" uniqKey="Jansson L">L. Jansson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Serino, G" uniqKey="Serino G">G. Serino</name></author><author><name sortKey="Strom, C" uniqKey="Strom C">C. Ström</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wadhwani, C" uniqKey="Wadhwani C">C. Wadhwani</name></author><author><name sortKey="Rapoport, D" uniqKey="Rapoport D">D. Rapoport</name></author><author><name sortKey="La Rosa, S" uniqKey="La Rosa S">S. la Rosa</name></author><author><name sortKey="Hess, T" uniqKey="Hess T">T. Hess</name></author><author><name sortKey="Kretschmar, S" uniqKey="Kretschmar S">S. Kretschmar</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Balevi, B" uniqKey="Balevi B">B. Balevi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Renvert, S" uniqKey="Renvert S">S. Renvert</name></author><author><name sortKey="Aghazadeh, A" uniqKey="Aghazadeh A">A. Aghazadeh</name></author><author><name sortKey="Hallstrom, H" uniqKey="Hallstrom H">H. Hallström</name></author><author><name sortKey="Persson, G R" uniqKey="Persson G">G. R. Persson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lindhe, J" uniqKey="Lindhe J">J. Lindhe</name></author><author><name sortKey="Meyle, J" uniqKey="Meyle J">J. Meyle</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Koldsland, O C" uniqKey="Koldsland O">O. C. Koldsland</name></author><author><name sortKey="Scheie, A A" uniqKey="Scheie A">A. A. Scheie</name></author><author><name sortKey="Aass, A M" uniqKey="Aass A">A. M. Aass</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Leonhardt, " uniqKey="Leonhardt ">Å. Leonhardt</name></author><author><name sortKey="Renvert, S" uniqKey="Renvert S">S. Renvert</name></author><author><name sortKey="Dahlen, G" uniqKey="Dahlen G">G. Dahlén</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Shibli, J A" uniqKey="Shibli J">J. A. Shibli</name></author><author><name sortKey="Martins, M C" uniqKey="Martins M">M. C. Martins</name></author><author><name sortKey="Lotufo, R F M" uniqKey="Lotufo R">R. F. M. Lotufo</name></author><author><name sortKey="Marcantonio, E" uniqKey="Marcantonio E">E. Marcantonio</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Shibli, J A" uniqKey="Shibli J">J. A. Shibli</name></author><author><name sortKey="Melo, L" uniqKey="Melo L">L. Melo</name></author><author><name sortKey="Ferrari, D S" uniqKey="Ferrari D">D. S. Ferrari</name></author><author><name sortKey="Figueiredo, L C" uniqKey="Figueiredo L">L. C. Figueiredo</name></author><author><name sortKey="Faveri, M" uniqKey="Faveri M">M. Faveri</name></author><author><name sortKey="Feres, M" uniqKey="Feres M">M. Feres</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Persson, G R" uniqKey="Persson G">G. R. Persson</name></author><author><name sortKey="Samuelsson, E" uniqKey="Samuelsson E">E. Samuelsson</name></author><author><name sortKey="Lindahl, C" uniqKey="Lindahl C">C. Lindahl</name></author><author><name sortKey="Renvert, S" uniqKey="Renvert S">S. Renvert</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Renvert, S" uniqKey="Renvert S">S. Renvert</name></author><author><name sortKey="Samuelsson, E" uniqKey="Samuelsson E">E. Samuelsson</name></author><author><name sortKey="Lindahl, C" uniqKey="Lindahl C">C. Lindahl</name></author><author><name sortKey="Persson, G R" uniqKey="Persson G">G. R. Persson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tastepe, C S" uniqKey="Tastepe C">C. S. Tastepe</name></author><author><name sortKey="Liu, Y" uniqKey="Liu Y">Y. Liu</name></author><author><name sortKey="Visscher, C M" uniqKey="Visscher C">C. M. Visscher</name></author><author><name sortKey="Wismeijer, D" uniqKey="Wismeijer D">D. Wismeijer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sahm, N" uniqKey="Sahm N">N. Sahm</name></author><author><name sortKey="Becker, J" uniqKey="Becker J">J. Becker</name></author><author><name sortKey="Santel, T" uniqKey="Santel T">T. Santel</name></author><author><name sortKey="Schwarz, F" uniqKey="Schwarz F">F. Schwarz</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Renvert, S" uniqKey="Renvert S">S. Renvert</name></author><author><name sortKey="Lindahl, C" uniqKey="Lindahl C">C. Lindahl</name></author><author><name sortKey="Jans Ker, A M R" uniqKey="Jans Ker A">A.-M. R. Jansåker</name></author><author><name sortKey="Persson, R G" uniqKey="Persson R">R. G. Persson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tastepe, C S" uniqKey="Tastepe C">C. S. Tastepe</name></author><author><name sortKey="Van Waas, R" uniqKey="Van Waas R">R. van Waas</name></author><author><name sortKey="Liu, Y" uniqKey="Liu Y">Y. Liu</name></author><author><name sortKey="Wismeijer, D" uniqKey="Wismeijer D">D. Wismeijer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Deppe, H" uniqKey="Deppe H">H. Deppe</name></author><author><name sortKey="Horch, H H" uniqKey="Horch H">H.-H. Horch</name></author><author><name sortKey="Schrodl, V" uniqKey="Schrodl V">V. Schrödl</name></author><author><name sortKey="Haczek, C" uniqKey="Haczek C">C. Haczek</name></author><author><name sortKey="Miethke, T" uniqKey="Miethke T">T. Miethke</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kreisler, M" uniqKey="Kreisler M">M. Kreisler</name></author><author><name sortKey="Kohnen, W" uniqKey="Kohnen W">W. Kohnen</name></author><author><name sortKey="Marinello, C" uniqKey="Marinello C">C. Marinello</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Haas, R" uniqKey="Haas R">R. Haas</name></author><author><name sortKey="Dortbudak, O" uniqKey="Dortbudak O">O. Dörtbudak</name></author><author><name sortKey="Mensdorff Pouilly, N" uniqKey="Mensdorff Pouilly N">N. Mensdorff-Pouilly</name></author><author><name sortKey="Mailath, G" uniqKey="Mailath G">G. Mailath</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Salmeron, S" uniqKey="Salmeron S">S. Salmeron</name></author><author><name sortKey="Rezende, M L R" uniqKey="Rezende M">M. L. R. Rezende</name></author><author><name sortKey="Consolaro, A" uniqKey="Consolaro A">A. Consolaro</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Schwarz, F" uniqKey="Schwarz F">F. Schwarz</name></author><author><name sortKey="Bieling, K" uniqKey="Bieling K">K. Bieling</name></author><author><name sortKey="Nuesry, E" uniqKey="Nuesry E">E. Nuesry</name></author><author><name sortKey="Sculean, A" uniqKey="Sculean A">A. Sculean</name></author><author><name sortKey="Becker, J" uniqKey="Becker J">J. Becker</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Schwarz, F" uniqKey="Schwarz F">F. Schwarz</name></author><author><name sortKey="Sculean, A" uniqKey="Sculean A">A. Sculean</name></author><author><name sortKey="Rothamel, D" uniqKey="Rothamel D">D. Rothamel</name></author><author><name sortKey="Schwenzer, K" uniqKey="Schwenzer K">K. Schwenzer</name></author><author><name sortKey="Georg, T" uniqKey="Georg T">T. Georg</name></author><author><name sortKey="Becker, J" uniqKey="Becker J">J. Becker</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Esposito, M" uniqKey="Esposito M">M. Esposito</name></author><author><name sortKey="Grusovin, M G" uniqKey="Grusovin M">M. G. Grusovin</name></author><author><name sortKey="De Angelis, N" uniqKey="De Angelis N">N. de Angelis</name></author><author><name sortKey="Camurati, A" uniqKey="Camurati A">A. Camurati</name></author><author><name sortKey="Campailla, M" uniqKey="Campailla M">M. Campailla</name></author><author><name sortKey="Felice, P" uniqKey="Felice P">P. Felice</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mombelli, A" uniqKey="Mombelli A">A. Mombelli</name></author><author><name sortKey="Feloutzis, A" uniqKey="Feloutzis A">A. Feloutzis</name></author><author><name sortKey="Br Gger, U" uniqKey="Br Gger U">U. Brägger</name></author><author><name sortKey="Lang, N P" uniqKey="Lang N">N. P. Lang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Renvert, S" uniqKey="Renvert S">S. Renvert</name></author><author><name sortKey="Lessem, J" uniqKey="Lessem J">J. Lessem</name></author><author><name sortKey="Dahlen, G" uniqKey="Dahlen G">G. Dahlén</name></author><author><name sortKey="Lindahl, C" uniqKey="Lindahl C">C. Lindahl</name></author><author><name sortKey="Svensson, M" uniqKey="Svensson M">M. Svensson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Salvi, G E" uniqKey="Salvi G">G. E. Salvi</name></author><author><name sortKey="Persson, G R" uniqKey="Persson G">G. R. Persson</name></author><author><name sortKey="Heitz Mayfield, L J A" uniqKey="Heitz Mayfield L">L. J. A. Heitz-Mayfield</name></author><author><name sortKey="Frei, M" uniqKey="Frei M">M. Frei</name></author><author><name sortKey="Lang, N P" uniqKey="Lang N">N. P. Lang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sch R, D" uniqKey="Sch R D">D. Schär</name></author><author><name sortKey="Ramseier, C A" uniqKey="Ramseier C">C. A. Ramseier</name></author><author><name sortKey="Eick, S" uniqKey="Eick S">S. Eick</name></author><author><name sortKey="Arweiler, N B" uniqKey="Arweiler N">N. B. Arweiler</name></author><author><name sortKey="Sculean, A" uniqKey="Sculean A">A. Sculean</name></author><author><name sortKey="Salvi, G E" uniqKey="Salvi G">G. E. Salvi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Porras, R" uniqKey="Porras R">R. Porras</name></author><author><name sortKey="Anderson, G B" uniqKey="Anderson G">G. B. Anderson</name></author><author><name sortKey="Caffesse, R" uniqKey="Caffesse R">R. Caffesse</name></author><author><name sortKey="Narendran, S" uniqKey="Narendran S">S. Narendran</name></author><author><name sortKey="Trejo, P M" uniqKey="Trejo P">P. M. Trejo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Renvert, S" uniqKey="Renvert S">S. Renvert</name></author><author><name sortKey="Lessem, J" uniqKey="Lessem J">J. Lessem</name></author><author><name sortKey="Dahlen, G" uniqKey="Dahlen G">G. Dahlén</name></author><author><name sortKey="Renvert, H" uniqKey="Renvert H">H. Renvert</name></author><author><name sortKey="Lindahl, C" uniqKey="Lindahl C">C. Lindahl</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Buchter, A" uniqKey="Buchter A">A. Büchter</name></author><author><name sortKey="Meyer, U" uniqKey="Meyer U">U. Meyer</name></author><author><name sortKey="Kruse Losler, B" uniqKey="Kruse Losler B">B. Kruse-Lösler</name></author><author><name sortKey="Joos, U" uniqKey="Joos U">U. Joos</name></author><author><name sortKey="Kleinheinz, J" uniqKey="Kleinheinz J">J. Kleinheinz</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Machtei, E E" uniqKey="Machtei E">E. E. Machtei</name></author><author><name sortKey="Frankenthal, S" uniqKey="Frankenthal S">S. Frankenthal</name></author><author><name sortKey="Levi, G" uniqKey="Levi G">G. Levi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Renvert, S" uniqKey="Renvert S">S. Renvert</name></author><author><name sortKey="Lessem, J" uniqKey="Lessem J">J. Lessem</name></author><author><name sortKey="Lindahl, C" uniqKey="Lindahl C">C. Lindahl</name></author><author><name sortKey="Svensson, M" uniqKey="Svensson M">M. Svensson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sgolastra, F" uniqKey="Sgolastra F">F. Sgolastra</name></author><author><name sortKey="Gatto, R" uniqKey="Gatto R">R. Gatto</name></author><author><name sortKey="Petrucci, A" uniqKey="Petrucci A">A. Petrucci</name></author><author><name sortKey="Monaco, A" uniqKey="Monaco A">A. Monaco</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hallstrom, H" uniqKey="Hallstrom H">H. Hallström</name></author><author><name sortKey="Persson, G R" uniqKey="Persson G">G. R. Persson</name></author><author><name sortKey="Lindgren, S" uniqKey="Lindgren S">S. Lindgren</name></author><author><name sortKey="Olofsson, M" uniqKey="Olofsson M">M. Olofsson</name></author><author><name sortKey="Renvert, S" uniqKey="Renvert S">S. Renvert</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lindhe, J" uniqKey="Lindhe J">J. Lindhe</name></author><author><name sortKey="Meyle, J" uniqKey="Meyle J">J. Meyle</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Javed, F" uniqKey="Javed F">F. Javed</name></author><author><name sortKey="Alghamdi, A S T" uniqKey="Alghamdi A">A. S. T. Alghamdi</name></author><author><name sortKey="Ahmed, A" uniqKey="Ahmed A">A. Ahmed</name></author><author><name sortKey="Mikami, T" uniqKey="Mikami T">T. Mikami</name></author><author><name sortKey="Ahmed, H B" uniqKey="Ahmed H">H. B. Ahmed</name></author><author><name sortKey="Tenenbaum, H C" uniqKey="Tenenbaum H">H. C. Tenenbaum</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rams, T E" uniqKey="Rams T">T. E. Rams</name></author><author><name sortKey="Degener, J E" uniqKey="Degener J">J. E. Degener</name></author><author><name sortKey="Van Winkelhoff, A J" uniqKey="Van Winkelhoff A">A. J. van Winkelhoff</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Van Winkelhoff, A J" uniqKey="Van Winkelhoff A">A. J. van Winkelhoff</name></author><author><name sortKey="Herrera Gonzales, D" uniqKey="Herrera Gonzales D">D. Herrera Gonzales</name></author><author><name sortKey="Winkel, E G" uniqKey="Winkel E">E. G. Winkel</name></author><author><name sortKey="Dellemijn Kippuw, N" uniqKey="Dellemijn Kippuw N">N. Dellemijn-Kippuw</name></author><author><name sortKey="Vandenbroucke Grauls, C M J E" uniqKey="Vandenbroucke Grauls C">C. M. J. E. Vandenbroucke-Grauls</name></author><author><name sortKey="Sanz, M" uniqKey="Sanz M">M. Sanz</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="French, G L" uniqKey="French G">G. L. French</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Havard, D B" uniqKey="Havard D">D. B. Havard</name></author><author><name sortKey="Ray, J M" uniqKey="Ray J">J. M. Ray</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Esposito, M" uniqKey="Esposito M">M. Esposito</name></author><author><name sortKey="Grusovin, M G" uniqKey="Grusovin M">M. G. Grusovin</name></author><author><name sortKey="Loli, V" uniqKey="Loli V">V. Loli</name></author><author><name sortKey="Coulthard, P" uniqKey="Coulthard P">P. Coulthard</name></author><author><name sortKey="Worthington, H V" uniqKey="Worthington H">H. V. Worthington</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Van Winkelhoff, A J" uniqKey="Van Winkelhoff A">A. J. van Winkelhoff</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lagervall, M" uniqKey="Lagervall M">M. Lagervall</name></author><author><name sortKey="Jansson, L E" uniqKey="Jansson L">L. E. Jansson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Albouy, J P" uniqKey="Albouy J">J.-P. Albouy</name></author><author><name sortKey="Abrahamsson, I" uniqKey="Abrahamsson I">I. Abrahamsson</name></author><author><name sortKey="Persson, L G" uniqKey="Persson L">L. G. Persson</name></author><author><name sortKey="Berglundh, T" uniqKey="Berglundh T">T. Berglundh</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Persson, L G" uniqKey="Persson L">L. G. Persson</name></author><author><name sortKey="Berglundh, T" uniqKey="Berglundh T">T. Berglundh</name></author><author><name sortKey="Sennerby, L" uniqKey="Sennerby L">L. Sennerby</name></author><author><name sortKey="Lindhe, J" uniqKey="Lindhe J">J. Lindhe</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Maximo, M B" uniqKey="Maximo M">M. B. Máximo</name></author><author><name sortKey="De Mendonca, A C" uniqKey="De Mendonca A">A. C. de Mendonça</name></author><author><name sortKey="Renata Santos, V" uniqKey="Renata Santos V">V. Renata Santos</name></author><author><name sortKey="Figueiredo, L C" uniqKey="Figueiredo L">L. C. Figueiredo</name></author><author><name sortKey="Feres, M" uniqKey="Feres M">M. Feres</name></author><author><name sortKey="Duarte, P M" uniqKey="Duarte P">P. M. Duarte</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Duarte, P M" uniqKey="Duarte P">P. M. Duarte</name></author><author><name sortKey="De Mendonca, A C" uniqKey="De Mendonca A">A. C. de Mendonça</name></author><author><name sortKey="Maximo, M B B" uniqKey="Maximo M">M. B. B. Máximo</name></author><author><name sortKey="Santos, V R" uniqKey="Santos V">V. R. Santos</name></author><author><name sortKey="Bastos, M F" uniqKey="Bastos M">M. F. Bastos</name></author><author><name sortKey="Nociti, F H" uniqKey="Nociti F">F. H. Nociti</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="De Waal, Y C M" uniqKey="De Waal Y">Y. C. M. de Waal</name></author><author><name sortKey="Raghoebar, G M" uniqKey="Raghoebar G">G. M. Raghoebar</name></author><author><name sortKey="Huddleston Slater, J J R" uniqKey="Huddleston Slater J">J. J. R. Huddleston Slater</name></author><author><name sortKey="Meijer, H J A" uniqKey="Meijer H">H. J. A. Meijer</name></author><author><name sortKey="Winkel, E G" uniqKey="Winkel E">E. G. Winkel</name></author><author><name sortKey="Van Winkelhoff, A J" uniqKey="Van Winkelhoff A">A. J. van Winkelhoff</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Serino, G" uniqKey="Serino G">G. Serino</name></author><author><name sortKey="Turri, A" uniqKey="Turri A">A. Turri</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Grunder, U" uniqKey="Grunder U">U. Grunder</name></author><author><name sortKey="Hurzeler, M B" uniqKey="Hurzeler M">M. B. Hürzeler</name></author><author><name sortKey="Schupbach, P" uniqKey="Schupbach P">P. Schüpbach</name></author><author><name sortKey="Strub, J R" uniqKey="Strub J">J. R. Strub</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nociti, F H" uniqKey="Nociti F">F. H. Nociti</name></author><author><name sortKey="Machado, M N" uniqKey="Machado M">M. Â. N. Machado</name></author><author><name sortKey="Stefani, C M" uniqKey="Stefani C">C. M. Stefani</name></author><author><name sortKey="Sallum, E A" uniqKey="Sallum E">E. A. Sallum</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hurzeler, M B" uniqKey="Hurzeler M">M. B. Hürzeler</name></author><author><name sortKey="Qui Oncs, C R" uniqKey="Qui Oncs C">C. R. Quiñoncs</name></author><author><name sortKey="Schupback, P" uniqKey="Schupback P">P. Schüpback</name></author><author><name sortKey="Morrison, E C" uniqKey="Morrison E">E. C. Morrison</name></author><author><name sortKey="Caffesse, R G" uniqKey="Caffesse R">R. G. Caffesse</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Roos Jans Ker, A M" uniqKey="Roos Jans Ker A">A.-M. Roos-Jansåker</name></author><author><name sortKey="Renvert, H" uniqKey="Renvert H">H. Renvert</name></author><author><name sortKey="Lindahl, C" uniqKey="Lindahl C">C. Lindahl</name></author><author><name sortKey="Renvert, S" uniqKey="Renvert S">S. Renvert</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Roos Jans Ker, A M" uniqKey="Roos Jans Ker A">A.-M. Roos-Jansåker</name></author><author><name sortKey="Lindahl, C" uniqKey="Lindahl C">C. Lindahl</name></author><author><name sortKey="Persson, G R" uniqKey="Persson G">G. R. Persson</name></author><author><name sortKey="Renvert, S" uniqKey="Renvert S">S. Renvert</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Aghazadeh, A" uniqKey="Aghazadeh A">A. Aghazadeh</name></author><author><name sortKey="Rutger Persson, G" uniqKey="Rutger Persson G">G. Rutger Persson</name></author><author><name sortKey="Renvert, S" uniqKey="Renvert S">S. Renvert</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wiltfang, J" uniqKey="Wiltfang J">J. Wiltfang</name></author><author><name sortKey="Zernial, O" uniqKey="Zernial O">O. Zernial</name></author><author><name sortKey="Behrens, E" uniqKey="Behrens E">E. Behrens</name></author><author><name sortKey="Schlegel, A" uniqKey="Schlegel A">A. Schlegel</name></author><author><name sortKey="Warnke, P H" uniqKey="Warnke P">P. H. Warnke</name></author><author><name sortKey="Becker, S T" uniqKey="Becker S">S. T. Becker</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Schwarz, F" uniqKey="Schwarz F">F. Schwarz</name></author><author><name sortKey="Sculean, A" uniqKey="Sculean A">A. Sculean</name></author><author><name sortKey="Bieling, K" uniqKey="Bieling K">K. Bieling</name></author><author><name sortKey="Ferrari, D" uniqKey="Ferrari D">D. Ferrari</name></author><author><name sortKey="Rothamel, D" uniqKey="Rothamel D">D. Rothamel</name></author><author><name sortKey="Becker, J" uniqKey="Becker J">J. Becker</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sahrmann, P" uniqKey="Sahrmann P">P. Sahrmann</name></author><author><name sortKey="Attin, T" uniqKey="Attin T">T. Attin</name></author><author><name sortKey="Schmidlin, P R" uniqKey="Schmidlin P">P. R. Schmidlin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Schwarz, F" uniqKey="Schwarz F">F. Schwarz</name></author><author><name sortKey="Sahm, N" uniqKey="Sahm N">N. Sahm</name></author><author><name sortKey="Schwarz, K" uniqKey="Schwarz K">K. Schwarz</name></author><author><name sortKey="Becker, J" uniqKey="Becker J">J. Becker</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Froum, S J" uniqKey="Froum S">S. J. Froum</name></author><author><name sortKey="Froum, S H" uniqKey="Froum S">S. H. Froum</name></author><author><name sortKey="Rosen, P S" uniqKey="Rosen P">P. S. Rosen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Roccuzzo, M" uniqKey="Roccuzzo M">M. Roccuzzo</name></author><author><name sortKey="Bonino, F" uniqKey="Bonino F">F. Bonino</name></author><author><name sortKey="Bonino, L" uniqKey="Bonino L">L. Bonino</name></author><author><name sortKey="Dalmasso, P" uniqKey="Dalmasso P">P. Dalmasso</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Roos Jans Ker, A M" uniqKey="Roos Jans Ker A">A.-M. Roos-Jansåker</name></author><author><name sortKey="Renvert, H" uniqKey="Renvert H">H. Renvert</name></author><author><name sortKey="Lindahl, C" uniqKey="Lindahl C">C. Lindahl</name></author><author><name sortKey="Renvert, S" uniqKey="Renvert S">S. Renvert</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Schwarz, F" uniqKey="Schwarz F">F. Schwarz</name></author><author><name sortKey="Jepsen, S" uniqKey="Jepsen S">S. Jepsen</name></author><author><name sortKey="Herten, M" uniqKey="Herten M">M. Herten</name></author><author><name sortKey="Sager, M" uniqKey="Sager M">M. Sager</name></author><author><name sortKey="Rothamel, D" uniqKey="Rothamel D">D. Rothamel</name></author><author><name sortKey="Becker, J" uniqKey="Becker J">J. Becker</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wohlfahrt, J C" uniqKey="Wohlfahrt J">J. C. Wohlfahrt</name></author><author><name sortKey="Lyngstadaas, S P" uniqKey="Lyngstadaas S">S. P. Lyngstadaas</name></author><author><name sortKey="R Nold, H J" uniqKey="R Nold H">H. J. Rønold</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gamal, A Y" uniqKey="Gamal A">A. Y. Gamal</name></author><author><name sortKey="Abdel Ghaffar, K A" uniqKey="Abdel Ghaffar K">K. A. Abdel-Ghaffar</name></author><author><name sortKey="Iacono, V J" uniqKey="Iacono V">V. J. Iacono</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Schwarz, F" uniqKey="Schwarz F">F. Schwarz</name></author><author><name sortKey="Bieling, K" uniqKey="Bieling K">K. Bieling</name></author><author><name sortKey="Latz, T" uniqKey="Latz T">T. Latz</name></author><author><name sortKey="Nuesry, E" uniqKey="Nuesry E">E. Nuesry</name></author><author><name sortKey="Becker, J" uniqKey="Becker J">J. Becker</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Baron, M" uniqKey="Baron M">M. Baron</name></author><author><name sortKey="Haas, R" uniqKey="Haas R">R. Haas</name></author><author><name sortKey="Dortbudak, O" uniqKey="Dortbudak O">O. Dörtbudak</name></author><author><name sortKey="Watzek, G" uniqKey="Watzek G">G. Watzek</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Roos Jans Ker, A M" uniqKey="Roos Jans Ker A">A.-M. Roos-Jansåker</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Romanos, G E" uniqKey="Romanos G">G. E. Romanos</name></author><author><name sortKey="Nentwig, G H" uniqKey="Nentwig G">G. H. Nentwig</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Schou, S" uniqKey="Schou S">S. Schou</name></author><author><name sortKey="Holmstrup, P" uniqKey="Holmstrup P">P. Holmstrup</name></author><author><name sortKey="J Rgensen, T" uniqKey="J Rgensen T">T. Jørgensen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Schou, S" uniqKey="Schou S">S. Schou</name></author><author><name sortKey="Holmstrup, P" uniqKey="Holmstrup P">P. Holmstrup</name></author><author><name sortKey="Skovgaard, L T" uniqKey="Skovgaard L">L. T. Skovgaard</name></author><author><name sortKey="Stoltze, K" uniqKey="Stoltze K">K. Stoltze</name></author><author><name sortKey="Hj Rting Hansen, E" uniqKey="Hj Rting Hansen E">E. Hjørting-Hansen</name></author><author><name sortKey="Gundersen, H J G" uniqKey="Gundersen H">H. J. G. Gundersen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Schou, S" uniqKey="Schou S">S. Schou</name></author><author><name sortKey="Holmstrup, P" uniqKey="Holmstrup P">P. Holmstrup</name></author><author><name sortKey="J Rgensen, T" uniqKey="J Rgensen T">T. Jørgensen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Khoshkam, V" uniqKey="Khoshkam V">V. Khoshkam</name></author><author><name sortKey="Chan, H" uniqKey="Chan H">H. Chan</name></author><author><name sortKey="Lin, G" uniqKey="Lin G">G. Lin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Heitz Mayfield, L J A" uniqKey="Heitz Mayfield L">L. J. A. Heitz-Mayfield</name></author><author><name sortKey="Salvi, G E" uniqKey="Salvi G">G. E. Salvi</name></author><author><name sortKey="Mombelli, A" uniqKey="Mombelli A">A. Mombelli</name></author><author><name sortKey="Faddy, M" uniqKey="Faddy M">M. Faddy</name></author><author><name sortKey="Lang, N P" uniqKey="Lang N">N. P. Lang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Leonhardt, " uniqKey="Leonhardt ">Å. Leonhardt</name></author><author><name sortKey="Dahlen, G" uniqKey="Dahlen G">G. Dahlén</name></author><author><name sortKey="Renvert, S" uniqKey="Renvert S">S. Renvert</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Charalampakis, G" uniqKey="Charalampakis G">G. Charalampakis</name></author><author><name sortKey="Rabe, P" uniqKey="Rabe P">P. Rabe</name></author><author><name sortKey="Leonhardt, " uniqKey="Leonhardt ">Å. Leonhardt</name></author><author><name sortKey="Dahlen, G" uniqKey="Dahlen G">G. Dahlén</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Horvath, S D" uniqKey="Horvath S">S. D. Horvath</name></author><author><name sortKey="Kohal, R J" uniqKey="Kohal R">R. J. Kohal</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Machtei, E E" uniqKey="Machtei E">E. E. Machtei</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Manzoor, B" uniqKey="Manzoor B">B. Manzoor</name></author><author><name sortKey="Suleiman, M" uniqKey="Suleiman M">M. Suleiman</name></author><author><name sortKey="Palmer, R M" uniqKey="Palmer R">R. M. Palmer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kolonidis, S G" uniqKey="Kolonidis S">S. G. Kolonidis</name></author><author><name sortKey="Renvert, S" uniqKey="Renvert S">S. Renvert</name></author><author><name sortKey="H Mmerle, C H F" uniqKey="H Mmerle C">C. H. F. Hämmerle</name></author><author><name sortKey="Lang, N P" uniqKey="Lang N">N. P. Lang</name></author><author><name sortKey="Harris, D" uniqKey="Harris D">D. Harris</name></author><author><name sortKey="Claffey, N" uniqKey="Claffey N">N. Claffey</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Horvath, S D" uniqKey="Horvath S">S. D. Horvath</name></author><author><name sortKey="Kohal, R J" uniqKey="Kohal R">R. J. Kohal</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mardinger, O" uniqKey="Mardinger O">O. Mardinger</name></author><author><name sortKey="Oubaid, S" uniqKey="Oubaid S">S. Oubaid</name></author><author><name sortKey="Manor, Y" uniqKey="Manor Y">Y. Manor</name></author><author><name sortKey="Nissan, J" uniqKey="Nissan J">J. Nissan</name></author><author><name sortKey="Chaushu, G" uniqKey="Chaushu G">G. Chaushu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Alsaadi, G" uniqKey="Alsaadi G">G. Alsaadi</name></author><author><name sortKey="Quirynen, M" uniqKey="Quirynen M">M. Quirynen</name></author><author><name sortKey="Van Steenberghe, D" uniqKey="Van Steenberghe D">D. van Steenberghe</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Grossmann, Y" uniqKey="Grossmann Y">Y. Grossmann</name></author><author><name sortKey="Levin, L" uniqKey="Levin L">L. Levin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Machtei, E E" uniqKey="Machtei E">E. E. Machtei</name></author><author><name sortKey="Mahler, D" uniqKey="Mahler D">D. Mahler</name></author><author><name sortKey="Oettinger Barak, O" uniqKey="Oettinger Barak O">O. Oettinger-Barak</name></author><author><name sortKey="Zuabi, O" uniqKey="Zuabi O">O. Zuabi</name></author><author><name sortKey="Horwitz, J" uniqKey="Horwitz J">J. Horwitz</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kim, Y K" uniqKey="Kim Y">Y.-K. Kim</name></author><author><name sortKey="Park, J Y" uniqKey="Park J">J.-Y. Park</name></author><author><name sortKey="Kim, S G" uniqKey="Kim S">S.-G. Kim</name></author><author><name sortKey="Lee, H J" uniqKey="Lee H">H.-J. Lee</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mardinger, O" uniqKey="Mardinger O">O. Mardinger</name></author><author><name sortKey="Ben Zvi, Y" uniqKey="Ben Zvi Y">Y. Ben Zvi</name></author><author><name sortKey="Chaushu, G" uniqKey="Chaushu G">G. Chaushu</name></author><author><name sortKey="Nissan, J" uniqKey="Nissan J">J. Nissan</name></author><author><name sortKey="Manor, Y" uniqKey="Manor Y">Y. Manor</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Eliasson, A" uniqKey="Eliasson A">A. Eliasson</name></author><author><name sortKey="Eriksson, T" uniqKey="Eriksson T">T. Eriksson</name></author><author><name sortKey="Johansson, A" uniqKey="Johansson A">A. Johansson</name></author><author><name sortKey="Wennerberg, A" uniqKey="Wennerberg A">A. Wennerberg</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Salvi, G E" uniqKey="Salvi G">G. E. Salvi</name></author><author><name sortKey="Br Gger, U" uniqKey="Br Gger U">U. Brägger</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pjetursson, B E" uniqKey="Pjetursson B">B. E. Pjetursson</name></author><author><name sortKey="Br Gger, U" uniqKey="Br Gger U">U. Brägger</name></author><author><name sortKey="Lang, N P" uniqKey="Lang N">N. P. Lang</name></author><author><name sortKey="Zwahlen, M" uniqKey="Zwahlen M">M. Zwahlen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Weber, H P" uniqKey="Weber H">H.-P. Weber</name></author><author><name sortKey="Sukotjo, C" uniqKey="Sukotjo C">C. Sukotjo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lang, N P" uniqKey="Lang N">N. P. Lang</name></author><author><name sortKey="Pjetursson, B E" uniqKey="Pjetursson B">B. E. Pjetursson</name></author><author><name sortKey="Tan, K" uniqKey="Tan K">K. Tan</name></author><author><name sortKey="Br Gger, U" uniqKey="Br Gger U">U. Brägger</name></author><author><name sortKey="Egger, M" uniqKey="Egger M">M. Egger</name></author><author><name sortKey="Zwahlen, M" uniqKey="Zwahlen M">M. Zwahlen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nickenig, H J" uniqKey="Nickenig H">H.-J. Nickenig</name></author><author><name sortKey="Sch Fer, C" uniqKey="Sch Fer C">C. Schäfer</name></author><author><name sortKey="Spiekermann, H" uniqKey="Spiekermann H">H. Spiekermann</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hita Carrillo, C" uniqKey="Hita Carrillo C">C. Hita-Carrillo</name></author><author><name sortKey="Hernandez Aliaga, M" uniqKey="Hernandez Aliaga M">M. Hernández-Aliaga</name></author><author><name sortKey="Calvo Guirado, J L" uniqKey="Calvo Guirado J">J.-L. Calvo-Guirado</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tonetti, M" uniqKey="Tonetti M">M. Tonetti</name></author><author><name sortKey="Palmer, R" uniqKey="Palmer R">R. Palmer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Esposito, M" uniqKey="Esposito M">M. Esposito</name></author><author><name sortKey="Grusovin, M G" uniqKey="Grusovin M">M. G. Grusovin</name></author><author><name sortKey="Worthington, H V" uniqKey="Worthington H">H. V. Worthington</name></author></analytic></biblStruct></listBibl></div1></back></TEI><pmc article-type="research-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Adv Med</journal-id><journal-id journal-id-type="iso-abbrev">Adv Med</journal-id><journal-id journal-id-type="publisher-id">AMED</journal-id><journal-title-group><journal-title>Advances in Medicine</journal-title></journal-title-group><issn pub-type="ppub">2356-6752</issn><issn pub-type="epub">2314-758X</issn><publisher><publisher-name>Hindawi Publishing Corporation</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">26556414</article-id><article-id pub-id-type="pmc">4590969</article-id><article-id pub-id-type="doi">10.1155/2014/487903</article-id><article-categories><subj-group subj-group-type="heading"><subject>Review Article</subject></subj-group></article-categories><title-group><article-title>Treatment Alternatives to Negotiate Peri-Implantitis</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Machtei</surname><given-names>Eli E.</given-names></name><xref ref-type="aff" rid="I1"></xref><xref ref-type="corresp" rid="cor1"><sup>*</sup></xref></contrib></contrib-group><aff id="I1"> Department of Periodontology, School of Graduate Dentistry, Rambam Health Care Campus and Faculty of Medicine, Technion (Israel Institute of Technology), Rambam HCC, 8 Ha'alia Hashnia Street, 31096 Haifa, Israel</aff><author-notes><corresp id="cor1">*Eli E. Machtei: <email>machtei@rambam.health.gov.il</email></corresp><fn fn-type="other"><p>Academic Editor: Silvana Barros</p></fn></author-notes><pub-date pub-type="ppub"><year>2014</year></pub-date><pub-date pub-type="epub"><day>15</day><month>6</month><year>2014</year></pub-date><volume>2014</volume><elocation-id>487903</elocation-id><history><date date-type="received"><day>4</day><month>11</month><year>2013</year></date><date date-type="rev-recd"><day>26</day><month>4</month><year>2014</year></date><date date-type="accepted"><day>28</day><month>4</month><year>2014</year></date></history><permissions><copyright-statement>Copyright © 2014 Eli E. Machtei.</copyright-statement><copyright-year>2014</copyright-year><license xlink:href="https://creativecommons.org/licenses/by/3.0/"><license-p>This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</license-p></license></permissions><abstract><p>Peri-implant diseases are becoming a major health issue in dentistry. Despite the magnitude of this problem and the potential grave consequences, commonly acceptable treatment protocols are missing. Hence, the present paper reviews the literature treatment of peri-implantitis in order to explore their benefits and limitations. Treatment of peri-implantitis may include surgical and nonsurgical approaches, either individually or combined. Nonsurgical therapy is aimed at removing local irritants from the implants' surface with or without surface decontamination and possibly some additional adjunctive therapies agents or devices. Systemic antibiotics may also be incorporated. Surgical therapy is aimed at removing any residual subgingival deposits and additionally reducing the peri-implant pockets depth. This can be done alone or in conjunction with either osseous respective approach or regenerative approach. Finally, if all fails, explantation might be the best alternative in order to arrest the destruction of the osseous structure around the implant, thus preserving whatever is left in this site for future reconstruction. The available literature is still lacking with large heterogeneity in the clinical response thus suggesting possible underlying predisposing conditions that are not all clear to us. Therefore, at present time treatment of peri-implantitis should be considered possible but not necessarily predictable.</p></abstract></article-meta></front><body><sec id="sec1"><title>1. Introduction</title><p>Peri-implantitis is becoming an ever growing oral health concern that is frequently encountered in the dental office. The number of dental implants that are currently placed annually is somewhat elusive; however, the best estimate available puts this figure at around fifteen million new implants (worldwide) every year [<xref rid="B1" ref-type="bibr">1</xref>]. Of these, how many will eventually develop peri-implant diseases is also debatable. Zitzmann and Berglundh on behalf of the VI workshop of the European Federation of Periodontology have suggested that 80 percent of the patients and 50 percent of the implants will develop peri-implant mucositis during the years. These corresponding figures for peri-implantitis are 28–56 percent of the patients and 12–43 percent of the implants [<xref rid="B2" ref-type="bibr">2</xref>]. To the contrary, Mombelli et al., on behalf of the 3rd European academy of osteointegration workshop in 2012, have suggested somewhat lower numbers for peri-implantitis: 20 percent of the subjects and 10% of the implants [<xref rid="B3" ref-type="bibr">3</xref>]. More recently, Atieh and coworkers [<xref rid="B4" ref-type="bibr">4</xref>] in a meta-analysis of 504 studies which included 1497 patients with 6293 implants reported the prevalence of peri-implant mucositis to be 63.4 percent (of the patients) and 30.7 percent (of the implants). A higher frequency of occurrence of peri-implant diseases was recorded for smokers with a summary estimate of 36.3 percent.</p><p>The reason for this large variation in the reported literature might be associated with patients variables such as smoking [<xref rid="B5" ref-type="bibr">5</xref>, <xref rid="B6" ref-type="bibr">6</xref>], preexisting periodontal disease [<xref rid="B7" ref-type="bibr">7</xref>, <xref rid="B8" ref-type="bibr">8</xref>], oral hygiene [<xref rid="B9" ref-type="bibr">9</xref>, <xref rid="B10" ref-type="bibr">10</xref>], quality of prosthetic reconstruction [<xref rid="B11" ref-type="bibr">11</xref>, <xref rid="B12" ref-type="bibr">12</xref>], and some systemic conditions and medications [<xref rid="B13" ref-type="bibr">13</xref>, <xref rid="B14" ref-type="bibr">14</xref>]. Koldsland and coworkers [<xref rid="B15" ref-type="bibr">15</xref>] have suggested a different approach to explain this variability. Using different threshold levels to define peri-implantitis (i.e., bone loss of >2 mm or >3 mm and implants probing depth of >4 mm and >6 mm), the prevalence of peri-implantitis varied significantly from 11.3 to 47.1 percent. Thus, with the current lack of universally accepted criteria for the definition of peri-implantitis, the use of different thresholds is likely to produce different prevalence rates. However, even with the more conservative estimates, the number of new implants that are likely to be affected by peri-implant diseases every year is the high million range, of which 7-8 million are likely to develop peri-implant mucositis while about 3-4 million will develop peri-implantitis.</p><p>Nevertheless, despite the magnitude of this problem and the potential grave consequences that may result from a nonresponsive peri-implantitis condition, a commonly acceptable treatment protocols are yet to be agreed upon. Hence, the purpose of this paper is to review the available literature pertaining to both surgical and nonsurgical therapies of peri-implantitis in order to explore their benefits and limitations (<xref ref-type="fig" rid="fig1">Figure 1</xref>).</p></sec><sec id="sec2"><title>2. Body </title><p>The treatment of peri-implantitis may include each of the following modalities, either individually or combined: nonsurgical therapy is aimed at removing local irritants from the implants' surface with or without surface decontamination and possibly some additional adjunctive therapies. Surgical therapy is aimed at removing any residual subgingival deposits and additionally reducing the peri-implant pockets depth. This can be done alone or in conjunction with either osseous respective therapy or the contrary regenerative approach. Finally, if all fails, explantation of the affected nonresponsive implant might be the best alternative in order to arrest the destruction of the osseous structure around the implant, thus preserving whatever is left in this site for future reconstruction.</p><sec id="sec2.1"><title>2.1. Nonsurgical Treatment of Peri-Implantitis </title><sec id="sec2.1.1"><title>2.1.1. Implant's Debridement</title><p>The microbial origin of peri-implantitis has been previously established [<xref rid="B16" ref-type="bibr">16</xref>]. Shibli et al. [<xref rid="B17" ref-type="bibr">17</xref>] in an experimental peri-implantitis study in the canine model have found<italic> Prevotella intermedia/nigrescens</italic> in 13.89% of implants at baseline and 100% of implants at other periods.<italic> Porphyromonas gingivalis</italic> was not detected at baseline, but after 20 and 40 days it was detected in 33.34% of implants and at 60 days it was detected in 29.03% of dental implants.<italic> Fusobacterium </italic>spp. were detected in all time points. Streptococci were detected in 16.67% of implants at baseline and in 83.34%, 72.22%, and 77.42% of implants at 20, 40, and 60 days, respectively.<italic> Campylobacter </italic>spp. and<italic> Candida </italic>spp. were detected in low proportions. Total viable count analysis showed significant difference after ligature placement (<italic>P</italic> < 0.0014). However, there was no significant qualitative difference, in spite of the difference among the periods. The same authors (2008) have compared the microbial biofilm of healthy and peri-implantitis implants; they found significantly higher mean counts of<italic> Porphyromonas gingivalis</italic>,<italic> Treponema denticola</italic>, and<italic> Tannerella forsythia</italic> in the peri-implantitis sites, both supra- and subgingivally. Also, the proportions of the pathogens from the red complex were elevated, while host-compatible beneficial microbial complexes were reduced in diseased compared with healthy implants. The microbiological profiles of supra- and subgingival environments did not differ substantially within each group [<xref rid="B18" ref-type="bibr">18</xref>]. Thus, the need for implant debridement in order to eliminate bacterial flora that is likely associated with the peri-implant disease is obvious.</p><p>However, the clinical efficacy of this treatment modality has been shown to be relatively limited. Persson et al. [<xref rid="B19" ref-type="bibr">19</xref>] in a single-blinded randomized longitudinal clinical study of mechanical nonsurgical treatment of peri-implantitis reported that the most prevalent bacteria were<italic> Fusobacterium nucleatum </italic>sp.,<italic> Staphylococcus</italic> sp.,<italic> Aggregatibacter actinomycetemcomitans</italic>,<italic> Helicobacter pylori</italic>, and<italic> Tannerella forsythia</italic>. 30 min after treatment (with curettes only),<italic> Aggregatibacter actinomycetemcomitans</italic> (serotype a),<italic> Lactobacillus acidophilus</italic>,<italic> Streptococcus anginosus</italic>, and<italic> Veillonella parvula</italic> were found at lower counts (<italic>P</italic> < 0.001). However, at 6 months, microbiological differences between baseline and 6-month samples were not significant for any species or between treatment methods in these peri-implantitis sites. Renvert et al. in a corresponding clinical report of this study [<xref rid="B20" ref-type="bibr">20</xref>] have shown minimal pocket reduction between baseline (5.1 mm) and 6-month (4.9 mm) measurements; <italic>P</italic> = 0.30. These minimal changes were attained in both groups (ultrasonic instruments and the hand held curettes). Plaque scores at treated implants decreased from 73% to 53% (<italic>P</italic> < 0.01). Bleeding scores also decreased (<italic>P</italic> < 0.01), again with no group differences.</p></sec><sec id="sec2.1.2"><title>2.1.2. Surface Decontamination</title><p>To try improving the outcome of nonsurgical therapy of peri-implantitis site, the use of surface decontamination has been studied extensively. This is usually being performed mechanically via the use of air abrasive devices or chemical agents.</p><p><italic>In vitro</italic> studies have confirmed the potency of this device to remove plaque and biofilm. Tastepe et al. [<xref rid="B21" ref-type="bibr">21</xref>] have studied the cleaning and modification of intraorally contaminated medium roughness titanium discs using calcium phosphate powder abrasive treatment. They have concluded that air powder abrasive methods using various agents were all efficient in removing the biofilm from contaminated titanium discs. Nonetheless, clinical studies of the efficacy of this treatment approach had produced mixed results. In a recent prospective, randomized, controlled clinical study, Sahm and coworkers [<xref rid="B22" ref-type="bibr">22</xref>] compared the efficacy of nonsurgical treatment of peri-implantitis using an air abrasive device versus mechanical debridement and local application of chlorhexidine solution. After six months, the air abrasive group revealed significantly higher changes in mean BOP scores when compared with mechanically treated sites (43.5 ± 27.7% versus 11.0 ± 15.7%). However, pocket reduction was minimal (0.6 mm) in both treatment groups. Likewise, clinical attachment level gains were minimal and very similar in both groups (0.4 ± 0.7 mm and 0.5 ± 0.8 mm, resp.). Likewise, Renvert et al. [<xref rid="B23" ref-type="bibr">23</xref>] in a nonsurgical treatment study of peri-implantitis patients have reported a mean pocket reduction after 6 months to be 0.9 mm following this intervention. While this seems to be slightly greater than that reported for debridement only, still the magnitude of these changes is not sufficient. Thus, none surprisingly, Tastepe et al. [<xref rid="B24" ref-type="bibr">24</xref>] in a recent review of the literature have concluded that the<italic> in vivo</italic> data on air powder abrasive treatment as an implant surface cleaning method is not sufficient to draw definitive conclusions.</p></sec><sec id="sec2.1.3"><title>2.1.3. The Use of Lasers</title><p>The efficacy of different laser wavelength to eliminate bacteria from implants' surface had been demonstrated<italic> in vitro</italic>. Deppe and coworkers [<xref rid="B25" ref-type="bibr">25</xref>] used a XeCl 308 nm excimer laser irradiation with a constant energy of 0.8 J/cm and a constant frequency of 20 Hz on peri-implantitis-associated bacteria<italic> in vitro</italic>. They have been able to show that 200 pulses were sufficient to reduce the replication of these anaerobic microorganisms for more than 99.9%. Likewise, Kreisler and coworkers [<xref rid="B26" ref-type="bibr">26</xref>], using an Er:YAG laser on different implant surfaces contaminated with<italic> Streptococcus sanguinis</italic>, were able to report that, compared to nonirradiated specimens, mean bacterial reductions ranged from 99.51% to 99.6% at a pulse energy of 60 mJ and from 99.92% to 99.94% (TPS) at 120 mJ. The adjunctive effect of photodynamic therapy in conjunction with soft laser therapy was also studied<italic> in vitro</italic> by Haas et al. [<xref rid="B27" ref-type="bibr">27</xref>]. After contaminating these rough surface implants with<italic> Actinobacillus actinomycetemcomitans</italic> or<italic> Porphyromonas gingivalis</italic> or<italic> Prevotella intermedia</italic>, these surfaces were then treated with a toluidine blue solution and irradiated with a diode soft laser with a wave length of 905 nm for 1 min. None of the smears obtained from the thus treated surfaces showed any bacterial growth, whereas the smears obtained from the controls showed unchanged growth of every target organism tested. Likewise, Salmeron et al. [<xref rid="B28" ref-type="bibr">28</xref>] in a preclinical rat model have studied laser therapy alone or with photodynamic therapy and compared them to both negative and positive controls for implant surface decontamination. The results of this histomorphometric study were then followed longitudinally: while photodynamic therapy showed some improved early (7 days) results; over longer time periods (>14 days), all methods produced similar results.</p><p>Here again, clinical studies have failed to support the<italic> in vitro</italic> microbiological results. Renvert [<xref rid="B23" ref-type="bibr">23</xref>] in his clinical study which explored different treatment modalities for peri-implantitis reported minimal (0.8 mm) pocket reduction around implants treated with Er:YAG laser. Likewise, Schwarz et al. [<xref rid="B29" ref-type="bibr">29</xref>] in a clinical and histological study using Er:YAG laser in peri-implantitis patients reported that while patients exhibited some improvements in the clinical parameter this amounted to approximately 0.5 mm for all time intervals (up to 24 months); furthermore, histopathological examination of tissue biopsies revealed a mixed chronic inflammatory cell infiltrate (macrophages, lymphocytes, and plasma cells) which seemed to be encapsulated by deposition of irregular bundles of fibrous connective tissue showing increased proliferation of vascular structures. Thus, they have concluded that a single course of nonsurgical treatment of peri-implantitis using ERL may not be sufficient for the maintenance of failing implants. These authors in yet another study [<xref rid="B30" ref-type="bibr">30</xref>] reported that mean value of BOP decreased in the Er:YAG treated group from 83% at baseline to 31% after 6 months while in the C group from 80% at baseline to 58% after 6 months. The sites treated with Er:YAG demonstrated a mean CAL change from 5.8 ± 1 mm at baseline to 5.1 ± 1.1 mm after 6 months; similarly, the C sites demonstrated a mean CAL gain from 6.2 ± 1.5 mm at baseline to 5.6 ± 1.6 mm at 6 months (the difference between the two groups being statistically insignificant). Most recently, Esposito and coworkers [<xref rid="B31" ref-type="bibr">31</xref>] in a one-year multicenter pragmatic randomized controlled clinical trial of the adjunctive use of light-activated disinfection (LAD) in the treatment of peri-implantitis have concluded that LAD therapy (FotoSan) with mechanical cleaning of implants affected by peri-implantitis did not improve any clinical outcomes when compared to mechanical cleaning alone up to 1 year after treatment.</p></sec><sec id="sec2.1.4"><title>2.1.4. The Adjunctive Effect of Local Delivery of Antibacterial Agents</title><p>To further improve the response to nonsurgical treatment of peri-implantitis, the use of local delivery of antibacterial agents has been advocated. As early as 2001, Mombelli and coworkers [<xref rid="B32" ref-type="bibr">32</xref>] explored the adjunctive effect of tetracycline fibers in the nonsurgical treatment of peri-implantitis. After twelve months, a significant decrease in frequency of detection was noted for<italic> Prevotella intermedia/nigrescens</italic>,<italic> Fusobacterium </italic>sp.,<italic> Bacteroides forsythus</italic>, and<italic> Campylobacter rectus</italic>. Clinically, mean pocket reduction was 1.2–1.9 mm which was maintained up to 12 months postop. However, three subjects have shown continuous deterioration in the clinical parameters and were thus removed from the study and are not included in the results.</p><p>Renvert and coworkers [<xref rid="B33" ref-type="bibr">33</xref>] in a 12-month clinical study of 32 patients with peri-implantitis were treated with minocycline microspheres or chlorhexidine gel as adjunct to mechanical debridement: At one year, pocket reduction amounted to only 0.6 mm with no difference between the two treatment groups. Salvi and coworkers [<xref rid="B34" ref-type="bibr">34</xref>] in a similar study reported some greater pocket reduction (1.6 mm) in implants treated with minocycline microspheres. However, 6 implants in six subjects (of the original 31 implants) required rescue treatment or were exited from the study all together, due to continuing attachment level loss despite this treatment. More recently, Schär et al. [<xref rid="B35" ref-type="bibr">35</xref>] reported that, 3 months following treatment with either minocycline microspheres of photodynamic therapy, implants of both groups yielded a statistically significant reduction in the number of BOP-positive sites compared with baseline. Changes in implants probing depth, while statistically significantly different from baseline, amounted to only 0.4 mm. One should keep in mind that the initial pocket depth in these sites was moderate. Likewise, CAL gain was approximately 0.25 mm.</p><p>The use of chlorhexidine irrigation was studied in a preclinical canine study by Porras et al. [<xref rid="B36" ref-type="bibr">36</xref>]. Subjects received dental prophylaxis and were randomly assigned to the control group (mechanical debridement and oral hygiene instructions) or to the test group (antiseptic therapy which included mechanical cleansing and oral hygiene instructions supplemented by local irrigation with chlorhexidine 0.12%, using a plastic syringe, and topical application of a 0.12% chlorhexidine gel). Both treatment modalities were effective in reducing peri-implant infection and implants probing depths and in improving attachment levels with no intergroup differences. Similarly, Sahm and coworkers [<xref rid="B22" ref-type="bibr">22</xref>] in a clinical trial of nonsurgical treatment of peri-implantitis sites reported that implants' mean pocket reduction was 0.8 mm and attachment level gain was also 0.8 mm when using mechanical debridement and adjunctive subgingival irrigation with CHX solution and gel application into the pockets. Likewise, Renvert et al. [<xref rid="B37" ref-type="bibr">37</xref>] have used chlorhexidine gel in conjunction with mechanical debridement for the treatment of moderate pocket sites around dental implants. Only moderate pocket reduction (0.43 mm) could be attained; however, bleeding on probing was significantly reduced from 86% of the sites at screening to 30% at the end of the study, one year later.</p><p>Büchter and coworkers [<xref rid="B38" ref-type="bibr">38</xref>] in a randomized clinical trial were using doxycycline gel in the peri-implant pockets as an adjunct implants mechanical therapy. Pocket reduction (1.15 mm) and CAL gain (1.17 mm) were significantly greater than those of the mechanical treatment only (0.56 mm for both outcomes).</p><p>More recently, our group has reported in a randomized double blind placebo controlled multicenter clinical trial on the use of chlorhexidine containing chips (Periochip) in the treatment of peri-implantitis [<xref rid="B39" ref-type="bibr">39</xref>]. In this study of moderate to severe peri-implantitis sites, chlorhexidine containing chips were repeatedly inserted into the peri-implant pockets every other week (unless pockets were already reduced to 5 mm or less) for a period of up to 3 months. This novel approach of repeated placement of chlorhexidine chips has resulted in a significant improvement of the peri-implant soft tissue parameters six months postop: pocket reduction (mean 2.29 mm) and attachment level gain (2.21 mm) were significantly better than those previously reported for nonsurgical treatment of peri-implantitis. Furthermore, 73% of these sites had had pocket reduction of 2 mm or greater, while 40 percent had pocket reduction of at least 3 mm.</p><p>Conversely, Renvert et al. [<xref rid="B40" ref-type="bibr">40</xref>] in a similar nonsurgical treatment study of moderate peri-implantitis sites used repeated subgingival application of minocycline microspheres (Arestin) once a month for up to three months. Mean pocket reduction in the deepest sites amounted to 0.9 mm in the experimental group.</p></sec><sec id="sec2.1.5"><title>2.1.5. Systemic Antibiotics</title><p>The use of systemic antibiotics as an adjunctive tool in nonsurgical periodontal therapy had been shown to have small but statistically significant added benefit over scaling and root planning alone [<xref rid="B41" ref-type="bibr">41</xref>]. Thus, the use of such protocols in the nonsurgical treatment of peri-implantitis would seem like a logical course to take. Hallström et al. [<xref rid="B42" ref-type="bibr">42</xref>] have compared, in a randomized clinical trial design, nonsurgical treatment of peri-implant mucositis with or without systemic antibiotics. Forty-eight subjects received nonsurgical debridement with or without systemic Azithromycin for four days and were followed during 6 months. Pocket reduction was 0.9 mm in the antibiotics group (1.4 mm in the deepest sites) and 0.5 mm in the debridement only group (0.8 mm in its deepest sites). However, these differences between the antibiotics and control group were not statistically significant.</p><p>Lindhe and Meyle [<xref rid="B43" ref-type="bibr">43</xref>] on behalf of the VI European workshop in periodontology have concluded that there was limited evidence that nonsurgical treatment of peri-implantitis with the adjunctive use of systemic antibiotics could resolve a number of peri-implantitis lesions. Most recently, Javed et al. [<xref rid="B44" ref-type="bibr">44</xref>] in a systematic review of the use of antibiotics in the treatment protocol of peri-implantitis concluded that the significance of adjunctive antibiotic therapy in the treatment of peri-implantitis remains controversial. A potential explanation for this minimal adjunctive effect for these systemic antibiotics comes from a recent study by Rams and coworkers [<xref rid="B45" ref-type="bibr">45</xref>]. In this study, a hundred and six peri-implantitis sites in 120 patients were sampled microbiologically and tested for potential antibiotic resistance. They found that one or more cultivable submucosal bacterial pathogens (most often<italic> Prevotella intermedia/nigrescens </italic>or<italic> Streptococcus constellatus</italic>) were resistant<italic> in vitro</italic> to clindamycin, amoxicillin, doxycycline, or metronidazole in 46.7%, 39.2%, 25%, and 21.7% of the peri-implantitis subjects, respectively. Overall, 71.7% of the 120 peri-implantitis subjects exhibited submucosal bacterial pathogens resistant<italic> in vitro</italic> to one or more of the tested antibiotics.</p><p>Another important issue that needs to be discussed<italic> vis-a-vis</italic> the use of systemic antibiotics for the treatment of peri-implantitis is the risk for antibiotic resistance as a worldwide health hazard. The wide spread use of antibiotics in medicine at large in the past fifty years is now back firing at our profession with the ever increasing prevalence of resistant bacterial strains [<xref rid="B46" ref-type="bibr">46</xref>, <xref rid="B47" ref-type="bibr">47</xref>]. This phenomenon is causing a medical crisis that might have severe and far reaching repercussions on the population. Thus, the use of antibiotics should be restricted to patients and conditions where it has been clearly shown to have significant benefits which outweigh the risks that are involved [<xref rid="B48" ref-type="bibr">48</xref>, <xref rid="B49" ref-type="bibr">49</xref>]. Thus, current research has not yet substantiated such benefits and consequently systemic antibiotics should be limited to acute phase of peri-implant infection rather than to be the treatment of choice for peri-implantitis [<xref rid="B50" ref-type="bibr">50</xref>].</p></sec></sec><sec id="sec2.2"><title>2.2. Surgical Treatment of Peri-Implantitis</title><sec id="sec2.2.1"><title>2.2.1. Open Flap Debridement</title><p>The clinical scenario in humans differs significantly from that in animals. The greatest difference is the inability, in most cases, to remove the prosthetic super structure in order to allow for a submerged healing of the regenerated sites. Thus, the results of many of the human clinical trials are less favorable and more diverse than these reported in animals models. Still, open flap debridement is the treatment of choice by many clinicians. Lagervall and Jansson [<xref rid="B51" ref-type="bibr">51</xref>] in a retrospective study of treatment outcome in patients with peri-implantitis performed in a private practice based clinical setting have reported that open flap debridement was selected for 47 percent of the sites affected by peri-implantitis. Albouy et al. [<xref rid="B52" ref-type="bibr">52</xref>] in a preclinical experimental peri-implantitis study in canines have compared responses to open flap debridement surgery (as a stand-alone procedure) in four different implants design and surface topographies. Two of the four TiUnite implants were lost after surgical therapy. Radiographic bone gain occurred at implants with turned, TiOblast, and SLA surfaces, while at TiUnite implants additional bone loss was found after treatment. Resolution of peri-implantitis was achieved in tissues surrounding implants with turned and TiOblast surfaces. Thus, they concluded that resolution of peri-implantitis following treatment without systemic or local antimicrobial therapy is possible, but the outcome of treatment is influenced by implant surface characteristics. Similarly, Persson et al. [<xref rid="B53" ref-type="bibr">53</xref>] have studied the effect of implants surface topography on reosseointegration in an experimental peri-implantitis model in the canines. Implants with turned surface were compared with SLA implants when treated with systemic antibiotics followed by open flap debridement. Treatment resulted in a 72% bone fill of the bone defects at turned sites and 76% at SLA sites. The amount of reosseointegration was 22% at turned sites and 84% at SLA sites. Nonetheless, while these variations do exist, open flap debridement offers a useful tool to negotiate peri-implant disease. Máximo et al. [<xref rid="B54" ref-type="bibr">54</xref>] in a short term clinical study were able to show that three months following access flap surgery all clinical parameters have improved. For the peri-implantitis groups, mean reduction in CAL was 2.3 ± 1.6 mm and mean implants pocket reduction was 3.1 ± 1.7 mm. Levels of<italic> Treponema denticola</italic>,<italic> Tannerella forsythia</italic>, and<italic> Parvimonas micra </italic>and of<italic> Fusobacterium nucleatum</italic> were significantly reduced after peri-implantitis therapy. In addition, counts of<italic> Porphyromonas gingivalis</italic> and<italic> Treponema socranskii </italic>and the proportions of red complex were also reduced. These same authors in a subsequent report have shown that TNF-alpha levels, initially much greater than healthy controls, were significantly reduced achieving the same level as the healthy group at 3 months after therapy [<xref rid="B55" ref-type="bibr">55</xref>]. Mechanical therapies alone were effective in treating mucositis and peri-implantitis over a period of 3 months. The open debridement procedure showed clinical and microbiological benefits on the treatment of peri-implantitis and could be safely used as a standard control group for future studies.</p></sec><sec id="sec2.2.2"><title>2.2.2. The Supplementary Use of Osseous Resection</title><p>The use of osteoplasty and/or ostectomy to allow for better adaptation of the surgical flap and thus further improve the surgical outcome has been studied extensively. de Waal and coworkers [<xref rid="B56" ref-type="bibr">56</xref>] reported on thirty patients (79 implants) with peri-implantitis that were treated with apically repositioned flap, bone recontouring, and surface debridement and decontamination with 0.12% chlorhexidine gluconate + 0.05% cetylpyridinium chloride or placebo. Nine implants in two patients in the placebo-group were lost due to severe persisting peri-implantitis. The test group showed a significantly greater reduction in bacterial load, but clinical improvement (i.e., bleeding, suppuration, implants pocket depth, and radiographic bone loss) was sizeable however similar in both groups.</p><p>Serino and Turri [<xref rid="B57" ref-type="bibr">57</xref>] reported on their two-year prospective clinical trial of thirty-one subjects (86 implants) treated for peri-implantitis using a surgical procedure based on pocket elimination and bone recontouring. Two years following treatment, 15 (48%) subjects had no signs of recurrent peri-implant disease; 24 patients (77%) had no implants with a probing pocket depth of 0.6 mm associated with bleeding and/or suppuration following probing. Nevertheless, 36 implants (42%) out of the original 86 had had persistent peri-implant disease despite this treatment. The proportion of implants that remained healthy following treatment was higher for those with minor initial bone loss (2–4 mm bone loss as assessed during surgery) compared with the implants with an initial bone loss of 0.5 mm (74% versus 40%). Among the eighteen implants with bone loss of 0.7 mm at baseline, seven were explanted.</p></sec><sec id="sec2.2.3"><title>2.2.3. The Complementary Use of Regenerative Techniques (<xref ref-type="fig" rid="fig2">Figure 2</xref>)</title><p>As early as 1993, Grunder et al. [<xref rid="B58" ref-type="bibr">58</xref>], in ligature-induced peri-implantitis study in canines using guided tissue regeneration with a nonresorbable ePTFE membrane and comparing it to flap surgery alone, reported that there were no differences between any of the clinical parameters in both the control and experimental sites from the submerged and nonsubmerged groups. Histologic and histomorphometric analyses also revealed no significant differences between groups with regard to new bone formation. Likewise, Nociti et al. [<xref rid="B59" ref-type="bibr">59</xref>] in a similar animal model compared different membranes, with and without additional bone graft, to flap surgery only for the treatment of peri-implantitis. Their results showed that debridement alone as well as grafting alone had the same effect as did either membrane. To the contrary, Hurzeler and coworkers [<xref rid="B60" ref-type="bibr">60</xref>] reported in a similar canine study that guided bone regeneration procedures resulted in the greatest amount of new bone formation, followed by bone grafts alone, and flap debridement. In humans, Roos-Jansåker et al. [<xref rid="B61" ref-type="bibr">61</xref>] were able to show similar response to therapy (implants pocket reduction of 2.9–3.4 mm and new bone fill of 1.4-1.5 mm) for peri-implantitis sites treated with either bone grafts alone or bone grafts in conjunction with resorbable collagen membrane. This same group [<xref rid="B62" ref-type="bibr">62</xref>], in a subsequent 3-year follow-up report, has found that this improvement was maintained almost unchanged three years later. Aghazadeh et al. have attempted to compare autogenous bone to bovine derived xenograft for the treatment of peri-implantitis [<xref rid="B63" ref-type="bibr">63</xref>]. At 12 months, bovine derived xenograft provided more radiographic bone fill than autogenous bone; however, the success for both surgical regenerative procedures was limited. More recently, Wiltfang et al. [<xref rid="B64" ref-type="bibr">64</xref>] have reported significant bone fill in a twelve-month clinical trial in which peri-implantitis sites were treated with surface decontamination and regenerative flap surgery that included a 1 : 1 ratio of autogenous and xenogeneic bone graft. Mean radiographic bone fill amounted to 3.5 mm. Schwarz et al. [<xref rid="B65" ref-type="bibr">65</xref>] presented a case series where twenty-two patients with moderate peri-implantitis were randomly treated with access flap surgery and the application of nanocrystalline hydroxyapatite (NHA) or a natural bone mineral in combination with a collagen membrane (NBM + CM). Clinical parameters were recorded at baseline and after 12, 18, and 24 months of nonsubmerged healing. After two years, both groups revealed clinically important probing depth reductions (NHA: 1.5 ± 0.6 mm; NBM + CM: 2.4 ± 0.8 mm) and clinical attachment level gains (NHA: 1.0 ± 0.4 mm; NBM + CM: 2.0 ± 0.8 mm). However, these clinical improvements seemed to be better in the NBM + CM.</p><p>Sahrmann et al. [<xref rid="B66" ref-type="bibr">66</xref>] in a recent systematic review have concluded that complete fill of the bony defect using GBR seems not to be a predictable outcome. The mucosal health status is left unconsidered in most studies. Well-controlled trials are needed to determine predictable treatment protocols for the successful regenerative treatment of peri-implantitis using GBR technique.</p><p>A possible explanation to this diversity in clinical response to regenerative surgical treatment around dental implants was suggested by Schwarz et al. [<xref rid="B67" ref-type="bibr">67</xref>]. In this study, three types of osseous defects around dental implants with peri-implantitis were treated with bone graft and resorbable collagen membranes. The circumferential defects sites yielded significantly better response than these sites with dehiscence type defect. Thus, defects' anatomy might affect the outcome of these regenerative techniques. Nonetheless, regenerative approach to peri-implantitis may at time produce significant improvement in these sites. Froum et al. [<xref rid="B68" ref-type="bibr">68</xref>] reported on long-term follow-up of 51 consecutively treated peri-implantitis sites (using combination of platelet-derived growth factor with an organic bovine bone or mineralized freeze-dried bone coverage with a collagen membrane or a subepithelial connective tissue graft). Probing depth reductions at 3 to 7.5 years of follow-up were 5.1–5.4 mm. Concomitant bone level gain was from 3.0 to 3.75 mm. None of these implants lost bone throughout the duration of the study. Another source for this diversity in implants response to regenerative treatment could be associated with implants surface topography. Roccuzzo and coworkers [<xref rid="B69" ref-type="bibr">69</xref>] reported on twenty-six patients with one crater-like defect, around either TPS or SLA dental implants, with a probing depth (PD) of 0.6. Following flap approach, the implant surface was mechanically debrided and treated using a 24% EDTA gel and a 1% chlorhexidine gel and the osseous defect filled with a bovine-derived xenograft (BDX); all sites were left to heal in a nonsubmerged environment. At one-year follow-up mean implants pocket depth reduction was 2.1 ± 1.2 mm in the TPS implants compared to 3.4 ± 1.7 mm in the SLA group (these differences being statistically significant). Complete defect fill was never found around TPS group, while it occurred in three out of 12 SLA implants. Finally, submergence of the dental implants during the healing of the regenerative procedure might have a beneficial effect on the outcome. Roos-Jansåker and coworkers [<xref rid="B70" ref-type="bibr">70</xref>] reported on a one-year case series of twelve patients with a progressive loss of > or = 3 threads (1.8 mm) following the first year of healing. Following flap reflection, implants were decontaminated with 3% hydrogen peroxide and a bone substitute (Algipore) was grafted with a resorbable collagen membrane that was placed over the grafted defect and secured with the cover screw and covered by flaps for 6-month submerged healing; after that time, the abutment was reconnected to the suprastructure. At twelve months, implant probing depth was reduced by 4.2 mm and a mean defect fill of 2.3 mm was achieved. However, comparisons of human trials between submerged and nonsubmerged healing protocols are yet to be done. Nevertheless, Schwarz et al. [<xref rid="B71" ref-type="bibr">71</xref>] compared nonsubmerged and submerged healing of ligature induced peri-implantitis in 5 beagle dogs (30 implants). In this study, both treatment procedures resulted in statistically significant improvements of all clinical parameters at both nonsubmerged and submerged implants. However, radiological improvements were only observed at submerged implant sites. Histomorphometrical analysis revealed that all nonsubmerged implants exhibited low amounts of new BIC (1.0–1.2%), while mean BIC was statistically significantly higher in the respective submerged implant groups (8.7%–44.8%).</p><p>The best grafting material to be used in the surgical management of peri-implantitis is yet to be determined. Different studies have employed different materials; however, the diversity in clinical design, defect morphology, outcome variables, and follow-up period makes their comparison nearly impossible [<xref rid="B66" ref-type="bibr">66</xref>, <xref rid="B72" ref-type="bibr">72</xref>–<xref rid="B76" ref-type="bibr">76</xref>]. One of the most likely regenerative materials that was least tested is autogenous bone graft. Romanos and Nentwig [<xref rid="B77" ref-type="bibr">77</xref>] reported on a comparative study of peri-implantitis sites treated with autogenous bone or a xenogeneic bone grafting material (BioOss) both covered with a collagen membrane. In this study, radiological resolution of the lesions was observed for most sites with no intergroup differences. Schou and coworkers used different decontamination agents and different regenerative materials for the treatment of experimental peri-implantitis in monkeys [<xref rid="B78" ref-type="bibr">78</xref>–<xref rid="B80" ref-type="bibr">80</xref>]. Autogenous bone alone was compared to autogenous bone plus membrane, membrane alone, or a conventional flap procedure alone as a negative control. The animals were sacrificed 6 months after treatment. Healthy peri-implant tissue was established irrespective of the applied surgical procedure. A mean bone gain of 4.7 mm was identified around implants treated with autogenous bone plus membrane, while 4.0 mm, 3.0 mm, and 1.9 mm of bone gain were recorded for the bone only, membrane only, and conventional flap only groups, respectively. Quantitative digital subtraction radiography confirmed considerable bone gain within defects treated with autogenous bone with or without membrane coverage. The bone gain, especially for defects treated with combined bone-membrane approach, seemed to be almost at the level before development of peri-implantitis. By contrast, 38 and 25% of the defect were on average characterized by bone gain when treated with membrane only or flaps only, respectively. Thus, the present studies demonstrate considerable bone regeneration after treatment of experimental peri-implantitis with autogenous bone graft particles in this monkey model.</p><p>Despite this ample piece of evidence showing good regenerative response with the use of regenerative materials, the superiority of this approach over a conventional open flap debridement is yet to be established. Khoshkam et al. [<xref rid="B81" ref-type="bibr">81</xref>] in a systematic review and meta-analysis aimed at evaluating the effectiveness of reconstructive procedures for treating peri-implantitis revealed that the weighted mean radiographic defect fill was 2.17 mm, probing depth reduction was 2.97 mm, clinical attachment level gain was 1.65 mm, and bleeding on probing reduction was 45.8%. Great variability in reparative outcomes was found attributed to patient factors, defect morphology, and reconstructive agents used. They have concluded however that, currently, there is a lack of evidence for supporting additional benefit of reconstructive procedures to the other treatment modalities for managing peri-implantitis.</p></sec><sec id="sec2.2.4"><title>2.2.4. Systemic Antibiotics to Supplement Surgical Flap Approach</title><p>Systemic antibiotics as adjunct to peri-implant flap surgery treatment are commonly used. Heitz-Mayfield and coworkers [<xref rid="B82" ref-type="bibr">82</xref>] have recently reported on a prospective clinical trial of thirty-six implants in 24 partially dentate patients with moderate to advanced peri-implantitis that were treated using an anti-infective surgical protocol incorporating open flap debridement and implant surface decontamination, with adjunctive systemic amoxicillin and metronidazole. At twelve months, mean pocket reduction was 2.6 mm with all treated implants having a mean PD < 5 mm. 47% of the implants had complete resolution of inflammation with no bleeding on probing. 92% of implants had stable crestal bone levels or bone gain. There were no significant effects of smoking on any of the treatment outcomes. Leonhardt et al. [<xref rid="B83" ref-type="bibr">83</xref>] reported on a five-year clinical, microbiological, and radiological study into the treatment of peri-implantitis. Surgical exposure of the lesions and cleaning of the implants were performed using hydrogen peroxide. The patients were than given systemic antibiotics according to a susceptibility test of target bacteria that were previously cultured. The treatment was evaluated clinically, microbiologically, and radiographically at 6 months, 1 year, and 5 years. Seven out of 26 implants with peri-implantitis at baseline were lost during the 5-year follow-up period despite a significant reduction in the presence of plaque and gingival bleeding. Four implants continued to lose bone, 9 had an unchanged bone level, and 6 gained bone. Five of the patients were treated with antibiotics directed against putative periodontopathogens, that is,<italic> A. actinomycetemcomitans</italic>,<italic> P. intermedia</italic>, or<italic> P. gingivalis</italic>; three patients were treated for presence of enterics (<italic>E. coli</italic> and<italic> E. cloacae</italic>); and, in one patient, treatment was directed against<italic> S. aureus</italic>.</p></sec></sec><sec id="sec2.3"><title>2.3. Explantation (<xref ref-type="fig" rid="fig3">Figure 3</xref>)</title><p>The management of peri-implantitis may at time be unpredictable especially for the more advanced lesion associated with severe bone loss [<xref rid="B84" ref-type="bibr">84</xref>, <xref rid="B85" ref-type="bibr">85</xref>]. This may in turn lead to further bone loss, increase in pocket depth and suppuration, and consequently severe damage to the alveolar bone. Thus, explantation as a treatment option that will help arrest the progression of the destructive process is sometime advocated [<xref rid="B86" ref-type="bibr">86</xref>]. Moreover, severely compromised dental implants might be at greater risk for mechanical fracture [<xref rid="B87" ref-type="bibr">87</xref>] which may lead to further peri-implant bone loss. However, explantation of such compromised implant will require additional treatment to replace the now missing implants. Reimplantation of a new implant in the sites of the previously diseased implant is the most logical treatment option [<xref rid="B88" ref-type="bibr">88</xref>]; however, this treatment approach is not without limitation: bone loss that has occurred around the diseased implant might not allow for straightforward reimplantation. Instead, sometimes an elaborate augmentation procedure will be required before this site is ready for a redo implant placement [<xref rid="B89" ref-type="bibr">89</xref>]. Mardinger et al. [<xref rid="B90" ref-type="bibr">90</xref>] in a retrospective analysis of the factors affecting the decision to replace failed implants after they have been removed reported that the chances of a patient with minor bone loss undergoing reimplantation were 20 times greater (odds ratio, 20.4) than those of a patient with severe bone loss. The main patient-related reasons for avoiding reimplantation were the additional costs (27%), fear of additional pain (17.7%), and fear of a second failure (16.2%).</p><p>The survival and success rates of dental implants in previously failed implant sites were first reported by Alsaadi and coworkers [<xref rid="B91" ref-type="bibr">91</xref>]. A total of 41 patients (58 implants) experienced the nonintegration. Of those, seven implants (in seven subjects) have failed again (which represents a survival rate of 87.9%). Similarly, Grossmann and Levin (2007) reported on the success and survival of single dental implants placed in sites of previously failed implants [<xref rid="B92" ref-type="bibr">92</xref>]. Seventy five patients (with a total of 96 implants) experienced failure of one or more implants. Of those, 31 implants in 28 patients were replaced with a similar implant placed in the same location. Nine of the replacement implants failed, resulting in an overall survival rate of 71%. Follow-up ranged from 6 to 46 months. Replacement of maxillary and mandibular failed implants was similar. All failures occurred during the first year after implant replacement. In a similar retrospective study, we have shown that of fifty-six patients with a total of 79 redo implants that were followed for three years, thirteen implants failed and that resulted in an overall survival rate of 83.5%. Successful implants had greater diameter (4.05 ± 0.52 mm) than failed implants (3.72 ± 0.56 mm) did; however, these differences were only marginal (<italic>P</italic> = 0.06). Conversely, smoking habits, implants length and location, mode of placement, and spontaneous exposure did not have a significant effect on the outcome of this procedure [<xref rid="B93" ref-type="bibr">93</xref>]. Kim and coworkers [<xref rid="B94" ref-type="bibr">94</xref>] were able to report somewhat better results for redo of dental implants into previously contaminated sites where an implant was removed. The survival rate of the second implant after removal of failed implant was 88.3%. The marginal bone loss at the final (two years) follow-up was minimal (0.33 ± 0.49 mm). No significant difference in the failure rate of the second implant was observed between the immediate and delayed replacement groups (<italic>P</italic> > 0.05). This slightly greater survival rate the second time around (compare to other studies) might be attributed to the use of smoking (a strong confounding condition) as an exclusion criterion. Even slightly higher figure (92.3% CSR) was reported by Mardinger and coworkers [<xref rid="B95" ref-type="bibr">95</xref>] in a private practice based clinical study.</p><p>Alternatively, sites where previous implants were retrieved might be rehabilitated using fixed partial denture anchored to proximal implants, natural teeth, or combination of the above. The dogma of one implant per one missing tooth can no longer be supported automatically. Eliasson et al. [<xref rid="B96" ref-type="bibr">96</xref>] in an eighteen-year retrospective study of 123 implant patients have shown that survival rates for dental prostheses supported by 2 and 3 implants were 96.8% and 97.6%, respectively. Furthermore, the mean bone loss at 5 years was 0.3 mm for the two groups. No significant differences in bone loss (<italic>P</italic> > 0.05), implant failure rate (<italic>P</italic> > 0.05), or incidence of mechanical complications (<italic>P</italic> > 0.05) were found. More recently, Salvi and Brägger [<xref rid="B97" ref-type="bibr">97</xref>] in a systematic review concluded that the number of implants supporting an FDP was not associated with the prevalence of mechanical or technical complications nor with the implant survival or success rates. Likewise, the option of replacing a lost/removed implant with a 3-unit tooth-supported FPD is also a solid alternative. Pjetursson et al. [<xref rid="B98" ref-type="bibr">98</xref>] in a literature review and meta-analysis have reported that the five-year survival rate of tooth-supported FPD was 93.8% compared to 95.2% for an implant-supported FPD (with no statistical differences). The 10-year survival rates were 89.2% and 86.7% for teeth- and implant-supported prostheses, respectively (<italic>P</italic> > 0.05).</p><p>Another valid alternative will be to do a hybrid tooth-implant-supported fixed partial denture. In a systematic review, Weber and Sukotjo [<xref rid="B99" ref-type="bibr">99</xref>] have shown that, after an observation period of at least six years, implant survival and prosthetic success were similar for implant supported and tooth to implant supported prostheses. Likewise, Lang et al. [<xref rid="B100" ref-type="bibr">100</xref>] in their systematic review on the survival and complications of combined tooth-implant-supported FPD reported 90.1% implants' survival after 5 years and 82.1% after 10 years. The corresponding figures for the FPD survival were 94.1% and 77.8% after five and ten years, respectively. These results are very similar (both for survival and success) to what was reported for teeth-born and implants-born fixed prosthesis. Thus, such rehabilitation may be considered in cases where a potential abutment tooth is present across an edentulous site where one of the implants has failed.</p><p>Contrary to common beliefs, the use of nonrigid connection in such hybrid prostheses is not recommended. Nickening et al. [<xref rid="B101" ref-type="bibr">101</xref>] in a five-year follow-up of eighty-four hybrid fixtures have shown low rate of complications in these prostheses with rigid connection (5.3%) while these restorations with nonrigid connection exhibited significantly greater rate of complications (28.5%). Another risk associated with nonrigid connection increases the risk for intrusion of the abutment teeth [<xref rid="B102" ref-type="bibr">102</xref>].</p></sec></sec><sec id="sec3"><title>3. Conclusions </title><p>In the present review, we went through the literature pertaining to treatment alternatives to peri-implant diseases and the great diversity that is being reflected from this data. Both nonsurgical and surgical treatment strategies have shown to yield some beneficial effect on the peri-implant disease. However, while some implants/patients seemed to have benefited greatly from these treatment regiments, others have responded less favorably.</p><p>The most frustrating piece of information is the heterogeneity in the clinical response of peri-implantitis sites that were treated similarly as it was reported in the different studies.</p><p>Good independent randomized control trials are scarce, and the need for such well-designed studies was highlighted by Tonetti et al. [<xref rid="B103" ref-type="bibr">103</xref>] on behalf of the VIII European workshop in periodontology. Likewise, Esposito and coworkers [<xref rid="B104" ref-type="bibr">104</xref>] in a recent systematic review and meta-analysis that tried to identify the most effective interventions for treating peri-implantitis around osseointegrated dental implants have concluded that there is no reliable evidence suggesting which could be the most effective interventions for treating peri-implantitis.</p><p>We are still in the dark when it comes to the following questions.<list list-type="roman-lower"><list-item><p>Which is the best decontaminating agent (or do we really need it all together)?</p></list-item><list-item><p>Can nonsurgical therapies solve the mild to moderate peri-implantitis condition without a need to resort to access flaps?</p></list-item><list-item><p>Are regenerative procedures superior to access flap only approach?</p></list-item><list-item><p>Which of the regenerative techniques is most suitable in cases with peri-implantitis?</p></list-item></list>With the ever growing prevalence of peri-implant diseases, the need to address these questions is both real and urgent. Until that time when these data are available, treatment of peri-implantitis should be considered as possible but not necessarily predictable.</p></sec></body><back><sec sec-type="conflict"><title>Conflict of Interests</title><p>The author declares the following potential conflict of interests: research grants and lecturing fees from Dexcel Pharma (manufacturer of PerioChip), free material samples from HA Systems (distributor of Arestin), research grant from GABA International (manufacturer of a variety of anti-infective medications), and research grant from Silonit, manufacturer of high-pressure implant irrigating device.</p></sec><ref-list><ref id="B1"><label>1</label><element-citation publication-type="other"><comment><ext-link ext-link-type="uri" xlink:href="http://www.idataresearch.com/research-categories/dental/dental-implants-market-research-reports/">http://www.idataresearch.com/research-categories/dental/dental-implants-market-research-reports/</ext-link></comment></element-citation></ref><ref id="B2"><label>2</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Zitzmann</surname><given-names>N. U.</given-names></name><name><surname>Berglundh</surname><given-names>T.</given-names></name></person-group><article-title>Definition and prevalence of peri-implant diseases</article-title><source><italic>Journal of Clinical Periodontology</italic></source><year>2008</year><volume>35</volume><issue>8, supplement</issue><fpage>286</fpage><lpage>291</lpage><pub-id pub-id-type="other">2-s2.0-50249118560</pub-id><pub-id pub-id-type="doi">10.1111/j.1600-051X.2008.01274.x</pub-id><pub-id pub-id-type="pmid">18724856</pub-id></element-citation></ref><ref id="B3"><label>3</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Mombelli</surname><given-names>A.</given-names></name><name><surname>Müller</surname><given-names>N.</given-names></name><name><surname>Cionca</surname><given-names>N.</given-names></name></person-group><article-title>The epidemiology of peri-implantitis</article-title><source><italic>Clinical Oral Implants Research</italic></source><year>2012</year><volume>23</volume><issue>supplement 6</issue><fpage>67</fpage><lpage>76</lpage><pub-id pub-id-type="other">2-s2.0-84867612726</pub-id><pub-id pub-id-type="doi">10.1111/j.1600-0501.2012.02541.x</pub-id><pub-id pub-id-type="pmid">23062130</pub-id></element-citation></ref><ref id="B4"><label>4</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Atieh</surname><given-names>M. A.</given-names></name><name><surname>Alsabeeha</surname><given-names>N. H.</given-names></name><name><surname>Faggion</surname><given-names>C. M.</given-names><suffix>Jr.</suffix></name><name><surname>Duncan</surname><given-names>W. J.</given-names></name></person-group><article-title>The frequency of peri-implant diseases: a systematic review and meta-analysis</article-title><source><italic>Journal of Periodontology</italic></source><year>2013</year><volume>84</volume><issue>11</issue><fpage>1586</fpage><lpage>1598</lpage><pub-id pub-id-type="doi">10.1902/jop.2012.120592</pub-id><pub-id pub-id-type="pmid">23237585</pub-id></element-citation></ref><ref id="B5"><label>5</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Rinke</surname><given-names>S.</given-names></name><name><surname>Ohl</surname><given-names>S.</given-names></name><name><surname>Ziebolz</surname><given-names>D.</given-names></name><name><surname>Lange</surname><given-names>K.</given-names></name><name><surname>Eickholz</surname><given-names>P.</given-names></name></person-group><article-title>Prevalence of periimplant disease in partially edentulous patients: a practice-based cross-sectional study</article-title><source><italic>Clinical Oral Implants Research</italic></source><year>2011</year><volume>22</volume><issue>8</issue><fpage>826</fpage><lpage>833</lpage><pub-id pub-id-type="other">2-s2.0-79960271002</pub-id><pub-id pub-id-type="doi">10.1111/j.1600-0501.2010.02061.x</pub-id><pub-id pub-id-type="pmid">21198898</pub-id></element-citation></ref><ref id="B6"><label>6</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Rodriguez-Argueta</surname><given-names>O. F.</given-names></name><name><surname>Figueiredo</surname><given-names>R.</given-names></name><name><surname>Valmaseda-Castellon</surname><given-names>E.</given-names></name><name><surname>Gay-Escoda</surname><given-names>C.</given-names></name></person-group><article-title>Postoperative complications in smoking patients treated with implants: a retrospective study</article-title><source><italic>Journal of Oral and Maxillofacial Surgery</italic></source><year>2011</year><volume>69</volume><issue>8</issue><fpage>2152</fpage><lpage>2157</lpage><pub-id pub-id-type="other">2-s2.0-79960745805</pub-id><pub-id pub-id-type="doi">10.1016/j.joms.2011.02.082</pub-id><pub-id pub-id-type="pmid">21676513</pub-id></element-citation></ref><ref id="B7"><label>7</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Cho-Yan Lee</surname><given-names>J.</given-names></name><name><surname>Mattheos</surname><given-names>N.</given-names></name><name><surname>Nixon</surname><given-names>K. C.</given-names></name><name><surname>Ivanovski</surname><given-names>S.</given-names></name></person-group><article-title>Residual periodontal pockets are a risk indicator for peri-implantitis in patients treated for periodontitis</article-title><source><italic>Clinical Oral Implants Research</italic></source><year>2012</year><volume>23</volume><issue>3</issue><fpage>325</fpage><lpage>333</lpage><pub-id pub-id-type="other">2-s2.0-84856861035</pub-id><pub-id pub-id-type="doi">10.1111/j.1600-0501.2011.02264.x</pub-id><pub-id pub-id-type="pmid">22092508</pub-id></element-citation></ref><ref id="B8"><label>8</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Roccuzzo</surname><given-names>M.</given-names></name><name><surname>Bonino</surname><given-names>F.</given-names></name><name><surname>Aglietta</surname><given-names>M.</given-names></name><name><surname>Dalmasso</surname><given-names>P.</given-names></name></person-group><article-title>Ten-year results of a three arms prospective cohort study on implants in periodontally compromised patients—part 2: clinical results</article-title><source><italic>Clinical Oral Implants Research</italic></source><year>2012</year><volume>23</volume><issue>4</issue><fpage>389</fpage><lpage>395</lpage><pub-id pub-id-type="other">2-s2.0-84858050169</pub-id><pub-id pub-id-type="doi">10.1111/j.1600-0501.2011.02309.x</pub-id><pub-id pub-id-type="pmid">22092445</pub-id></element-citation></ref><ref id="B9"><label>9</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Carcuac</surname><given-names>O.</given-names></name><name><surname>Jansson</surname><given-names>L.</given-names></name></person-group><article-title>Peri-implantitis in a specialist clinic of periodontology. Clinical features and risk indicators</article-title><source><italic>Swedish Dental Journal</italic></source><year>2010</year><volume>34</volume><issue>2</issue><fpage>53</fpage><lpage>61</lpage><pub-id pub-id-type="pmid">20701213</pub-id></element-citation></ref><ref id="B10"><label>10</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Serino</surname><given-names>G.</given-names></name><name><surname>Ström</surname><given-names>C.</given-names></name></person-group><article-title>Peri-implantitis in partially edentulous patients: association with inadequate plaque control</article-title><source><italic>Clinical Oral Implants Research</italic></source><year>2009</year><volume>20</volume><issue>2</issue><fpage>169</fpage><lpage>174</lpage><pub-id pub-id-type="other">2-s2.0-58449098740</pub-id><pub-id pub-id-type="doi">10.1111/j.1600-0501.2008.01627.x</pub-id><pub-id pub-id-type="pmid">19077152</pub-id></element-citation></ref><ref id="B11"><label>11</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Wadhwani</surname><given-names>C.</given-names></name><name><surname>Rapoport</surname><given-names>D.</given-names></name><name><surname>la Rosa</surname><given-names>S.</given-names></name><name><surname>Hess</surname><given-names>T.</given-names></name><name><surname>Kretschmar</surname><given-names>S.</given-names></name></person-group><article-title>Radiographic detection and characteristic patterns of residual excess cement associated with cement-retained implant restorations: a clinical report</article-title><source><italic>Journal of Prosthetic Dentistry</italic></source><year>2012</year><volume>107</volume><issue>3</issue><fpage>151</fpage><lpage>157</lpage><pub-id pub-id-type="other">2-s2.0-84858055290</pub-id><pub-id pub-id-type="doi">10.1016/S0022-3913(12)60046-8</pub-id><pub-id pub-id-type="pmid">22385690</pub-id></element-citation></ref><ref id="B12"><label>12</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Balevi</surname><given-names>B.</given-names></name></person-group><article-title>Implant-supported cantilevered fixed partial dentures</article-title><source><italic>Evidence-Based Dentistry</italic></source><year>2010</year><volume>11</volume><issue>2</issue><fpage>48</fpage><lpage>49</lpage><pub-id pub-id-type="other">2-s2.0-77954186390</pub-id><pub-id pub-id-type="doi">10.1038/sj.ebd.6400721</pub-id><pub-id pub-id-type="pmid">20577285</pub-id></element-citation></ref><ref id="B13"><label>13</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Renvert</surname><given-names>S.</given-names></name><name><surname>Aghazadeh</surname><given-names>A.</given-names></name><name><surname>Hallström</surname><given-names>H.</given-names></name><name><surname>Persson</surname><given-names>G. R.</given-names></name></person-group><article-title>Factors related to peri-implantitis—a retrospective study</article-title><source><italic>Clinical Oral Implants Research</italic></source><year>2014</year><volume>25</volume><issue>4</issue><fpage>522</fpage><lpage>529</lpage><pub-id pub-id-type="doi">10.1111/clr.12208</pub-id><pub-id pub-id-type="pmid">23772670</pub-id></element-citation></ref><ref id="B14"><label>14</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Lindhe</surname><given-names>J.</given-names></name><name><surname>Meyle</surname><given-names>J.</given-names></name></person-group><article-title>Peri-implant diseases: consensus Report of the Sixth European Workshop on Periodontology</article-title><source><italic>Journal of Clinical Periodontology</italic></source><year>2008</year><volume>35</volume><issue>8, supplement</issue><fpage>282</fpage><lpage>285</lpage><pub-id pub-id-type="other">2-s2.0-50249133685</pub-id><pub-id pub-id-type="doi">10.1111/j.1600-051X.2008.01283.x</pub-id><pub-id pub-id-type="pmid">18724855</pub-id></element-citation></ref><ref id="B15"><label>15</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Koldsland</surname><given-names>O. C.</given-names></name><name><surname>Scheie</surname><given-names>A. A.</given-names></name><name><surname>Aass</surname><given-names>A. M.</given-names></name></person-group><article-title>Prevalence of peri-implantitis related to severity of the disease with different degrees of bone loss</article-title><source><italic>Journal of Periodontology</italic></source><year>2010</year><volume>81</volume><issue>2</issue><fpage>231</fpage><lpage>238</lpage><pub-id pub-id-type="other">2-s2.0-77649198273</pub-id><pub-id pub-id-type="doi">10.1902/jop.2009.090269</pub-id><pub-id pub-id-type="pmid">20151801</pub-id></element-citation></ref><ref id="B16"><label>16</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Leonhardt</surname><given-names>Å.</given-names></name><name><surname>Renvert</surname><given-names>S.</given-names></name><name><surname>Dahlén</surname><given-names>G.</given-names></name></person-group><article-title>Microbial findings at failing implants</article-title><source><italic>Clinical Oral Implants Research</italic></source><year>1999</year><volume>10</volume><issue>5</issue><fpage>339</fpage><lpage>345</lpage><pub-id pub-id-type="other">2-s2.0-0033212203</pub-id><pub-id pub-id-type="pmid">10551058</pub-id></element-citation></ref><ref id="B17"><label>17</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Shibli</surname><given-names>J. A.</given-names></name><name><surname>Martins</surname><given-names>M. C.</given-names></name><name><surname>Lotufo</surname><given-names>R. F. M.</given-names></name><name><surname>Marcantonio</surname><given-names>E.</given-names><suffix>Jr.</suffix></name></person-group><article-title>Microbiologic and radiographic analysis of ligature-induced peri-implantitis with different dental implant surfaces</article-title><source><italic>The International Journal of Oral & Maxillofacial Implants</italic></source><year>2003</year><volume>18</volume><issue>3</issue><fpage>383</fpage><lpage>390</lpage><pub-id pub-id-type="other">2-s2.0-0041418178</pub-id><pub-id pub-id-type="pmid">12814313</pub-id></element-citation></ref><ref id="B18"><label>18</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Shibli</surname><given-names>J. A.</given-names></name><name><surname>Melo</surname><given-names>L.</given-names></name><name><surname>Ferrari</surname><given-names>D. S.</given-names></name><name><surname>Figueiredo</surname><given-names>L. C.</given-names></name><name><surname>Faveri</surname><given-names>M.</given-names></name><name><surname>Feres</surname><given-names>M.</given-names></name></person-group><article-title>Composition of supra- and subgingival biofilm of subjects with healthy and diseased implants</article-title><source><italic>Clinical Oral Implants Research</italic></source><year>2008</year><volume>19</volume><issue>10</issue><fpage>975</fpage><lpage>982</lpage><pub-id pub-id-type="other">2-s2.0-51849130299</pub-id><pub-id pub-id-type="doi">10.1111/j.1600-0501.2008.01566.x</pub-id><pub-id pub-id-type="pmid">18828812</pub-id></element-citation></ref><ref id="B19"><label>19</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Persson</surname><given-names>G. R.</given-names></name><name><surname>Samuelsson</surname><given-names>E.</given-names></name><name><surname>Lindahl</surname><given-names>C.</given-names></name><name><surname>Renvert</surname><given-names>S.</given-names></name></person-group><article-title>Mechanical non-surgical treatment of peri-implantitis: a single-blinded randomized longitudinal clinical study. II. Microbiological results</article-title><source><italic>Journal of Clinical Periodontology</italic></source><year>2010</year><volume>37</volume><issue>6</issue><fpage>563</fpage><lpage>573</lpage><pub-id pub-id-type="other">2-s2.0-77952412046</pub-id><pub-id pub-id-type="doi">10.1111/j.1600-051X.2010.01561.x</pub-id><pub-id pub-id-type="pmid">20507380</pub-id></element-citation></ref><ref id="B20"><label>20</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Renvert</surname><given-names>S.</given-names></name><name><surname>Samuelsson</surname><given-names>E.</given-names></name><name><surname>Lindahl</surname><given-names>C.</given-names></name><name><surname>Persson</surname><given-names>G. R.</given-names></name></person-group><article-title>Mechanical non-surgical treatment of peri-implantitis: a double-blind randomized longitudinal clinical study. I: clinical results</article-title><source><italic>Journal of Clinical Periodontology</italic></source><year>2009</year><volume>36</volume><issue>7</issue><fpage>604</fpage><lpage>609</lpage><pub-id pub-id-type="other">2-s2.0-68049118694</pub-id><pub-id pub-id-type="doi">10.1111/j.1600-051X.2009.01421.x</pub-id><pub-id pub-id-type="pmid">19538334</pub-id></element-citation></ref><ref id="B21"><label>21</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Tastepe</surname><given-names>C. S.</given-names></name><name><surname>Liu</surname><given-names>Y.</given-names></name><name><surname>Visscher</surname><given-names>C. M.</given-names></name><name><surname>Wismeijer</surname><given-names>D.</given-names></name></person-group><article-title>Cleaning and modification of intraorally contaminated titanium discs with calcium phosphate powder abrasive treatment</article-title><source><italic>Clinical Oral Implants Research</italic></source><year>2012</year><pub-id pub-id-type="other">2-s2.0-84864541707</pub-id><pub-id pub-id-type="doi">10.1111/j.1600-0501.2012.02536.x</pub-id></element-citation></ref><ref id="B22"><label>22</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Sahm</surname><given-names>N.</given-names></name><name><surname>Becker</surname><given-names>J.</given-names></name><name><surname>Santel</surname><given-names>T.</given-names></name><name><surname>Schwarz</surname><given-names>F.</given-names></name></person-group><article-title>Non-surgical treatment of peri-implantitis using an air-abrasive device or mechanical debridement and local application of chlorhexidine: a prospective, randomized, controlled clinical study</article-title><source><italic>Journal of Clinical Periodontology</italic></source><year>2011</year><volume>38</volume><issue>9</issue><fpage>872</fpage><lpage>878</lpage><pub-id pub-id-type="other">2-s2.0-80051782232</pub-id><pub-id pub-id-type="doi">10.1111/j.1600-051X.2011.01762.x</pub-id><pub-id pub-id-type="pmid">21770995</pub-id></element-citation></ref><ref id="B23"><label>23</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Renvert</surname><given-names>S.</given-names></name><name><surname>Lindahl</surname><given-names>C.</given-names></name><name><surname>Jansåker</surname><given-names>A.-M. R.</given-names></name><name><surname>Persson</surname><given-names>R. G.</given-names></name></person-group><article-title>Treatment of peri-implantitis using an Er:YAG laser or an air-abrasive device: a randomized clinical trial</article-title><source><italic>Journal of Clinical Periodontology</italic></source><year>2011</year><volume>38</volume><issue>1</issue><fpage>65</fpage><lpage>73</lpage><pub-id pub-id-type="other">2-s2.0-78650332614</pub-id><pub-id pub-id-type="doi">10.1111/j.1600-051X.2010.01646.x</pub-id><pub-id pub-id-type="pmid">21091527</pub-id></element-citation></ref><ref id="B24"><label>24</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Tastepe</surname><given-names>C. S.</given-names></name><name><surname>van Waas</surname><given-names>R.</given-names></name><name><surname>Liu</surname><given-names>Y.</given-names></name><name><surname>Wismeijer</surname><given-names>D.</given-names></name></person-group><article-title>Air powder abrasive treatment as an implant surface cleaning method: a literature review</article-title><source><italic>The International Journal of Oral & Maxillofacial Implants</italic></source><year>2012</year><volume>27</volume><issue>6</issue><fpage>1461</fpage><lpage>1473</lpage><pub-id pub-id-type="other">2-s2.0-84880173117</pub-id><pub-id pub-id-type="pmid">23189298</pub-id></element-citation></ref><ref id="B25"><label>25</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Deppe</surname><given-names>H.</given-names></name><name><surname>Horch</surname><given-names>H.-H.</given-names></name><name><surname>Schrödl</surname><given-names>V.</given-names></name><name><surname>Haczek</surname><given-names>C.</given-names></name><name><surname>Miethke</surname><given-names>T.</given-names></name></person-group><article-title>Effect of 308-nm excimer laser light on peri-implantitis-associated bacteria—an in vitro investigation</article-title><source><italic>Lasers in Medical Science</italic></source><year>2007</year><volume>22</volume><issue>4</issue><fpage>223</fpage><lpage>227</lpage><pub-id pub-id-type="other">2-s2.0-35448929488</pub-id><pub-id pub-id-type="doi">10.1007/s10103-007-0441-2</pub-id><pub-id pub-id-type="pmid">17318664</pub-id></element-citation></ref><ref id="B26"><label>26</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Kreisler</surname><given-names>M.</given-names></name><name><surname>Kohnen</surname><given-names>W.</given-names></name><name><surname>Marinello</surname><given-names>C.</given-names></name><etal></etal></person-group><article-title>Bactericidal effect of the Er:YAG laser on dental implant surfaces: an in vitro study</article-title><source><italic>Journal of Periodontology</italic></source><year>2002</year><volume>73</volume><issue>11</issue><fpage>1292</fpage><lpage>1298</lpage><pub-id pub-id-type="other">2-s2.0-0036867429</pub-id><pub-id pub-id-type="doi">10.1902/jop.2002.73.11.1292</pub-id><pub-id pub-id-type="pmid">12479633</pub-id></element-citation></ref><ref id="B27"><label>27</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Haas</surname><given-names>R.</given-names></name><name><surname>Dörtbudak</surname><given-names>O.</given-names></name><name><surname>Mensdorff-Pouilly</surname><given-names>N.</given-names></name><name><surname>Mailath</surname><given-names>G.</given-names></name></person-group><article-title>Elimination of bacteria on different implant surfaces through photosensitization and soft laser: an in vitro study</article-title><source><italic>Clinical Oral Implants Research</italic></source><year>1997</year><volume>8</volume><issue>4</issue><fpage>249</fpage><lpage>254</lpage><pub-id pub-id-type="other">2-s2.0-0031197228</pub-id><pub-id pub-id-type="pmid">9586470</pub-id></element-citation></ref><ref id="B28"><label>28</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Salmeron</surname><given-names>S.</given-names></name><name><surname>Rezende</surname><given-names>M. L. R.</given-names></name><name><surname>Consolaro</surname><given-names>A.</given-names></name><etal></etal></person-group><article-title>Laser therapy as an effective method for implant surface decontamination: a histomorphometric study in rats</article-title><source><italic>Journal of Periodontology</italic></source><year>2013</year><volume>84</volume><issue>5</issue><fpage>641</fpage><lpage>649</lpage><pub-id pub-id-type="other">2-s2.0-84877155670</pub-id><pub-id pub-id-type="doi">10.1902/jop.2012.120166</pub-id><pub-id pub-id-type="pmid">22680303</pub-id></element-citation></ref><ref id="B29"><label>29</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Schwarz</surname><given-names>F.</given-names></name><name><surname>Bieling</surname><given-names>K.</given-names></name><name><surname>Nuesry</surname><given-names>E.</given-names></name><name><surname>Sculean</surname><given-names>A.</given-names></name><name><surname>Becker</surname><given-names>J.</given-names></name></person-group><article-title>Clinical and histological healing pattern of peri-implantitis lesions following non-surgical treatment with an Er:YAG laser</article-title><source><italic>Lasers in Surgery and Medicine</italic></source><year>2006</year><volume>38</volume><issue>7</issue><fpage>663</fpage><lpage>671</lpage><pub-id pub-id-type="other">2-s2.0-33748034741</pub-id><pub-id pub-id-type="doi">10.1002/lsm.20347</pub-id><pub-id pub-id-type="pmid">16634072</pub-id></element-citation></ref><ref id="B30"><label>30</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Schwarz</surname><given-names>F.</given-names></name><name><surname>Sculean</surname><given-names>A.</given-names></name><name><surname>Rothamel</surname><given-names>D.</given-names></name><name><surname>Schwenzer</surname><given-names>K.</given-names></name><name><surname>Georg</surname><given-names>T.</given-names></name><name><surname>Becker</surname><given-names>J.</given-names></name></person-group><article-title>Clinical evaluation of an Er:YAG laser for nonsurgical treatment of periimplantitis: a pilot study</article-title><source><italic>Clinical Oral Implants Research</italic></source><year>2005</year><volume>16</volume><issue>1</issue><fpage>44</fpage><lpage>52</lpage><pub-id pub-id-type="other">2-s2.0-17444420317</pub-id><pub-id pub-id-type="doi">10.1111/j.1600-0501.2004-01051.x</pub-id><pub-id pub-id-type="pmid">15642030</pub-id></element-citation></ref><ref id="B31"><label>31</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Esposito</surname><given-names>M.</given-names></name><name><surname>Grusovin</surname><given-names>M. G.</given-names></name><name><surname>de Angelis</surname><given-names>N.</given-names></name><name><surname>Camurati</surname><given-names>A.</given-names></name><name><surname>Campailla</surname><given-names>M.</given-names></name><name><surname>Felice</surname><given-names>P.</given-names></name></person-group><article-title>The adjunctive use of light-activated disinfection (LAD) with FotoSan is ineffective in the treatment of peri-implantitis: 1-year results from a multicentre pragmatic randomised controlled trial</article-title><source><italic>European Journal of Oral Implantology</italic></source><year>2013</year><volume>6</volume><issue>2</issue><fpage>109</fpage><lpage>119</lpage><pub-id pub-id-type="pmid">23926583</pub-id></element-citation></ref><ref id="B32"><label>32</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Mombelli</surname><given-names>A.</given-names></name><name><surname>Feloutzis</surname><given-names>A.</given-names></name><name><surname>Brägger</surname><given-names>U.</given-names></name><name><surname>Lang</surname><given-names>N. P.</given-names></name></person-group><article-title>Treatment of peri-implantitis by local delivery of tetracycline: clinical, microbiological and radiological results</article-title><source><italic>Clinical Oral Implants Research</italic></source><year>2001</year><volume>12</volume><issue>4</issue><fpage>287</fpage><lpage>294</lpage><pub-id pub-id-type="other">2-s2.0-0035434744</pub-id><pub-id pub-id-type="pmid">11488856</pub-id></element-citation></ref><ref id="B33"><label>33</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Renvert</surname><given-names>S.</given-names></name><name><surname>Lessem</surname><given-names>J.</given-names></name><name><surname>Dahlén</surname><given-names>G.</given-names></name><name><surname>Lindahl</surname><given-names>C.</given-names></name><name><surname>Svensson</surname><given-names>M.</given-names></name></person-group><article-title>Topical minocycline microspheres versus topical chlorhexidine gel as an adjunct to mechanical debridement of incipient peri-implant infections: a randomized clinical trial</article-title><source><italic>Journal of Clinical Periodontology</italic></source><year>2006</year><volume>33</volume><issue>5</issue><fpage>362</fpage><lpage>369</lpage><pub-id pub-id-type="other">2-s2.0-33645731777</pub-id><pub-id pub-id-type="doi">10.1111/j.1600-051X.2006.00919.x</pub-id><pub-id pub-id-type="pmid">16634959</pub-id></element-citation></ref><ref id="B34"><label>34</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Salvi</surname><given-names>G. E.</given-names></name><name><surname>Persson</surname><given-names>G. R.</given-names></name><name><surname>Heitz-Mayfield</surname><given-names>L. J. A.</given-names></name><name><surname>Frei</surname><given-names>M.</given-names></name><name><surname>Lang</surname><given-names>N. P.</given-names></name></person-group><article-title>Adjunctive local antibiotic therapy in the treatment of peri-implantitis II: clinical and radiographic outcomes</article-title><source><italic>Clinical Oral Implants Research</italic></source><year>2007</year><volume>18</volume><issue>3</issue><fpage>281</fpage><lpage>285</lpage><pub-id pub-id-type="other">2-s2.0-34547181757</pub-id><pub-id pub-id-type="doi">10.1111/j.1600-0501.2007.01377.x</pub-id><pub-id pub-id-type="pmid">17355354</pub-id></element-citation></ref><ref id="B35"><label>35</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Schär</surname><given-names>D.</given-names></name><name><surname>Ramseier</surname><given-names>C. A.</given-names></name><name><surname>Eick</surname><given-names>S.</given-names></name><name><surname>Arweiler</surname><given-names>N. B.</given-names></name><name><surname>Sculean</surname><given-names>A.</given-names></name><name><surname>Salvi</surname><given-names>G. E.</given-names></name></person-group><article-title>Anti-infective therapy of peri-implantitis with adjunctive local drug delivery or photodynamic therapy: six-month outcomes of a prospective randomized clinical trial</article-title><source><italic>Clinical Oral Implants Research</italic></source><year>2013</year><volume>24</volume><issue>1</issue><fpage>104</fpage><lpage>110</lpage><pub-id pub-id-type="other">2-s2.0-84871707769</pub-id><pub-id pub-id-type="doi">10.1111/j.1600-0501.2012.02494.x</pub-id><pub-id pub-id-type="pmid">22568744</pub-id></element-citation></ref><ref id="B36"><label>36</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Porras</surname><given-names>R.</given-names></name><name><surname>Anderson</surname><given-names>G. B.</given-names></name><name><surname>Caffesse</surname><given-names>R.</given-names></name><name><surname>Narendran</surname><given-names>S.</given-names></name><name><surname>Trejo</surname><given-names>P. M.</given-names></name></person-group><article-title>Clinical response to 2 different therapeutic regimens to treat peri-implant mucositis</article-title><source><italic>Journal of Periodontology</italic></source><year>2002</year><volume>73</volume><issue>10</issue><fpage>1118</fpage><lpage>1125</lpage><pub-id pub-id-type="other">2-s2.0-0036776001</pub-id><pub-id pub-id-type="doi">10.1902/jop.2002.73.10.1118</pub-id><pub-id pub-id-type="pmid">12416768</pub-id></element-citation></ref><ref id="B37"><label>37</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Renvert</surname><given-names>S.</given-names></name><name><surname>Lessem</surname><given-names>J.</given-names></name><name><surname>Dahlén</surname><given-names>G.</given-names></name><name><surname>Renvert</surname><given-names>H.</given-names></name><name><surname>Lindahl</surname><given-names>C.</given-names></name></person-group><article-title>Mechanical and repeated antimicrobial therapy using a local drug delivery system in the treatment of peri-implantitis: a randomized clinical trial</article-title><source><italic>Journal of Periodontology</italic></source><year>2008</year><volume>79</volume><issue>5</issue><fpage>836</fpage><lpage>844</lpage><pub-id pub-id-type="other">2-s2.0-44349088751</pub-id><pub-id pub-id-type="doi">10.1902/jop.2008.070347</pub-id><pub-id pub-id-type="pmid">18454662</pub-id></element-citation></ref><ref id="B38"><label>38</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Büchter</surname><given-names>A.</given-names></name><name><surname>Meyer</surname><given-names>U.</given-names></name><name><surname>Kruse-Lösler</surname><given-names>B.</given-names></name><name><surname>Joos</surname><given-names>U.</given-names></name><name><surname>Kleinheinz</surname><given-names>J.</given-names></name></person-group><article-title>Sustained release of doxycycline for the treatment of peri-implantitis: randomised controlled trial</article-title><source><italic>British Journal of Oral and Maxillofacial Surgery</italic></source><year>2004</year><volume>42</volume><issue>5</issue><fpage>439</fpage><lpage>444</lpage><pub-id pub-id-type="other">2-s2.0-4444327118</pub-id><pub-id pub-id-type="doi">10.1016/j.bjoms.2004.06.005</pub-id><pub-id pub-id-type="pmid">15336770</pub-id></element-citation></ref><ref id="B39"><label>39</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Machtei</surname><given-names>E. E.</given-names></name><name><surname>Frankenthal</surname><given-names>S.</given-names></name><name><surname>Levi</surname><given-names>G.</given-names></name><etal></etal></person-group><article-title>Treatment of peri-implantitis using multiple applications of chlorhexidine chips: a double-blind, randomized multi-centre clinical trial</article-title><source><italic>Journal of Clinical Periodontology</italic></source><year>2012</year><volume>39</volume><issue>12</issue><fpage>1198</fpage><lpage>1205</lpage><pub-id pub-id-type="other">2-s2.0-84869489537</pub-id><pub-id pub-id-type="doi">10.1111/jcpe.12006</pub-id><pub-id pub-id-type="pmid">23020659</pub-id></element-citation></ref><ref id="B40"><label>40</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Renvert</surname><given-names>S.</given-names></name><name><surname>Lessem</surname><given-names>J.</given-names></name><name><surname>Lindahl</surname><given-names>C.</given-names></name><name><surname>Svensson</surname><given-names>M.</given-names></name></person-group><article-title>Treatment of incipient peri-implant infections using topical minocycline microspheres versus topical chlorhexidine gel as an adjunct to mechanical debridement</article-title><source><italic>Journal of the International Academy of Periodontology</italic></source><year>2004</year><volume>6</volume><issue>4, supplement</issue><fpage>154</fpage><lpage>159</lpage><pub-id pub-id-type="other">2-s2.0-21644452117</pub-id><pub-id pub-id-type="pmid">15536784</pub-id></element-citation></ref><ref id="B41"><label>41</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Sgolastra</surname><given-names>F.</given-names></name><name><surname>Gatto</surname><given-names>R.</given-names></name><name><surname>Petrucci</surname><given-names>A.</given-names></name><name><surname>Monaco</surname><given-names>A.</given-names></name></person-group><article-title>Effectiveness of systemic amoxicillin/metronidazole as adjunctive therapy to scaling and root planing in the treatment of chronic periodontitis: a systematic review and meta-analysis</article-title><source><italic>Journal of Periodontology</italic></source><year>2012</year><volume>83</volume><issue>10</issue><fpage>1257</fpage><lpage>1269</lpage><pub-id pub-id-type="other">2-s2.0-84867318968</pub-id><pub-id pub-id-type="doi">10.1902/jop.2012.110625</pub-id><pub-id pub-id-type="pmid">22220767</pub-id></element-citation></ref><ref id="B42"><label>42</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Hallström</surname><given-names>H.</given-names></name><name><surname>Persson</surname><given-names>G. R.</given-names></name><name><surname>Lindgren</surname><given-names>S.</given-names></name><name><surname>Olofsson</surname><given-names>M.</given-names></name><name><surname>Renvert</surname><given-names>S.</given-names></name></person-group><article-title>Systemic antibiotics and debridement of peri-implant mucositis. A randomized clinical trial</article-title><source><italic>Journal of Clinical Periodontology</italic></source><year>2012</year><volume>39</volume><issue>6</issue><fpage>574</fpage><lpage>581</lpage><pub-id pub-id-type="other">2-s2.0-84861083002</pub-id><pub-id pub-id-type="doi">10.1111/j.1600-051X.2012.01884.x</pub-id><pub-id pub-id-type="pmid">22571225</pub-id></element-citation></ref><ref id="B43"><label>43</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Lindhe</surname><given-names>J.</given-names></name><name><surname>Meyle</surname><given-names>J.</given-names></name></person-group><article-title>Peri-implant diseases: consensus Report of the Sixth European Workshop on Periodontology</article-title><source><italic>Journal of Clinical Periodontology</italic></source><year>2008</year><volume>35</volume><issue>8, supplement</issue><fpage>282</fpage><lpage>285</lpage><pub-id pub-id-type="other">2-s2.0-50249133685</pub-id><pub-id pub-id-type="doi">10.1111/j.1600-051X.2008.01283.x</pub-id><pub-id pub-id-type="pmid">18724855</pub-id></element-citation></ref><ref id="B44"><label>44</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Javed</surname><given-names>F.</given-names></name><name><surname>Alghamdi</surname><given-names>A. S. T.</given-names></name><name><surname>Ahmed</surname><given-names>A.</given-names></name><name><surname>Mikami</surname><given-names>T.</given-names></name><name><surname>Ahmed</surname><given-names>H. B.</given-names></name><name><surname>Tenenbaum</surname><given-names>H. C.</given-names></name></person-group><article-title>Clinical efficacy of antibiotics in the treatment of peri-implantitis</article-title><source><italic>International Dental Journal</italic></source><year>2013</year><volume>63</volume><issue>4</issue><fpage>169</fpage><lpage>176</lpage><pub-id pub-id-type="other">2-s2.0-84880855331</pub-id><pub-id pub-id-type="doi">10.1111/idj.12034</pub-id><pub-id pub-id-type="pmid">23879251</pub-id></element-citation></ref><ref id="B45"><label>45</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Rams</surname><given-names>T. E.</given-names></name><name><surname>Degener</surname><given-names>J. E.</given-names></name><name><surname>van Winkelhoff</surname><given-names>A. J.</given-names></name></person-group><article-title>Antibiotic resistance in human peri-implantitis microbiota</article-title><source><italic>Clinical Oral Implants Research</italic></source><year>2014</year><volume>25</volume><issue>1</issue><fpage>82</fpage><lpage>90</lpage><pub-id pub-id-type="doi">10.1111/clr.12160</pub-id><pub-id pub-id-type="pmid">23551701</pub-id></element-citation></ref><ref id="B46"><label>46</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>van Winkelhoff</surname><given-names>A. J.</given-names></name><name><surname>Herrera Gonzales</surname><given-names>D.</given-names></name><name><surname>Winkel</surname><given-names>E. G.</given-names></name><name><surname>Dellemijn-Kippuw</surname><given-names>N.</given-names></name><name><surname>Vandenbroucke-Grauls</surname><given-names>C. M. J. E.</given-names></name><name><surname>Sanz</surname><given-names>M.</given-names></name></person-group><article-title>Antimicrobial resistance in the subgingival microflora in patients with adult periodontitis: a comparison between the Netherlands and Spain</article-title><source><italic>Journal of Clinical Periodontology</italic></source><year>2000</year><volume>27</volume><issue>2</issue><fpage>79</fpage><lpage>86</lpage><pub-id pub-id-type="other">2-s2.0-0034131948</pub-id><pub-id pub-id-type="pmid">10703651</pub-id></element-citation></ref><ref id="B47"><label>47</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>French</surname><given-names>G. L.</given-names></name></person-group><article-title>The continuing crisis in antibiotic resistance</article-title><source><italic>International Journal of Antimicrobial Agents</italic></source><year>2010</year><volume>36</volume><issue>supplement 3</issue><fpage>S3</fpage><lpage>S7</lpage><pub-id pub-id-type="other">2-s2.0-78649712445</pub-id><pub-id pub-id-type="doi">10.1016/S0924-8579(10)70003-0</pub-id><pub-id pub-id-type="pmid">21129629</pub-id></element-citation></ref><ref id="B48"><label>48</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Havard</surname><given-names>D. B.</given-names></name><name><surname>Ray</surname><given-names>J. M.</given-names></name></person-group><article-title>How can we as dentists minimize our contribution to the problem of antibiotic resistance?</article-title><source><italic>Oral and Maxillofacial Surgery Clinics of North America</italic></source><year>2011</year><volume>23</volume><issue>4</issue><fpage>551</fpage><lpage>555</lpage><pub-id pub-id-type="other">2-s2.0-80053599153</pub-id><pub-id pub-id-type="doi">10.1016/j.coms.2011.07.009</pub-id><pub-id pub-id-type="pmid">21982608</pub-id></element-citation></ref><ref id="B49"><label>49</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Esposito</surname><given-names>M.</given-names></name><name><surname>Grusovin</surname><given-names>M. G.</given-names></name><name><surname>Loli</surname><given-names>V.</given-names></name><name><surname>Coulthard</surname><given-names>P.</given-names></name><name><surname>Worthington</surname><given-names>H. V.</given-names></name></person-group><article-title>Does antibiotic prophylaxis at implant placement decrease early implant failures? A Cochrane systematic review</article-title><source><italic>European Journal of Oral Implantology</italic></source><year>2010</year><volume>3</volume><issue>2</issue><fpage>101</fpage><lpage>110</lpage><pub-id pub-id-type="other">2-s2.0-77956206139</pub-id><pub-id pub-id-type="pmid">20623035</pub-id></element-citation></ref><ref id="B50"><label>50</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>van Winkelhoff</surname><given-names>A. J.</given-names></name></person-group><article-title>Antibiotics in the treatment of peri-implantitis</article-title><source><italic>European Journal of Oral Implantology</italic></source><year>2012</year><volume>5</volume><issue>supplement</issue><fpage>S43</fpage><lpage>S50</lpage><pub-id pub-id-type="other">2-s2.0-84864878061</pub-id><pub-id pub-id-type="pmid">22834393</pub-id></element-citation></ref><ref id="B51"><label>51</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Lagervall</surname><given-names>M.</given-names></name><name><surname>Jansson</surname><given-names>L. E.</given-names></name></person-group><article-title>Treatment outcome in patients with peri-implantitis in a periodontal clinic: a retrospective study</article-title><source><italic>Journal of Periodontology</italic></source><year>2013</year><volume>84</volume><issue>10</issue><fpage>1365</fpage><lpage>1373</lpage><pub-id pub-id-type="doi">10.1902/jop.2012.120555</pub-id><pub-id pub-id-type="pmid">23237584</pub-id></element-citation></ref><ref id="B52"><label>52</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Albouy</surname><given-names>J.-P.</given-names></name><name><surname>Abrahamsson</surname><given-names>I.</given-names></name><name><surname>Persson</surname><given-names>L. G.</given-names></name><name><surname>Berglundh</surname><given-names>T.</given-names></name></person-group><article-title>Implant surface characteristics influence the outcome of treatment of peri-implantitis: an experimental study in dogs</article-title><source><italic>Journal of Clinical Periodontology</italic></source><year>2011</year><volume>38</volume><issue>1</issue><fpage>58</fpage><lpage>64</lpage><pub-id pub-id-type="other">2-s2.0-78650321810</pub-id><pub-id pub-id-type="doi">10.1111/j.1600-051X.2010.01631.x</pub-id><pub-id pub-id-type="pmid">21092053</pub-id></element-citation></ref><ref id="B53"><label>53</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Persson</surname><given-names>L. G.</given-names></name><name><surname>Berglundh</surname><given-names>T.</given-names></name><name><surname>Sennerby</surname><given-names>L.</given-names></name><name><surname>Lindhe</surname><given-names>J.</given-names></name></person-group><article-title>Re-osseointegration after treatment of peri-implantitis at different implant surfaces—an experimental study in the dog</article-title><source><italic>Clinical Oral Implants Research</italic></source><year>2001</year><volume>12</volume><issue>6</issue><fpage>595</fpage><lpage>603</lpage><pub-id pub-id-type="other">2-s2.0-0035651183</pub-id><pub-id pub-id-type="pmid">11737103</pub-id></element-citation></ref><ref id="B54"><label>54</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Máximo</surname><given-names>M. B.</given-names></name><name><surname>de Mendonça</surname><given-names>A. C.</given-names></name><name><surname>Renata Santos</surname><given-names>V.</given-names></name><name><surname>Figueiredo</surname><given-names>L. C.</given-names></name><name><surname>Feres</surname><given-names>M.</given-names></name><name><surname>Duarte</surname><given-names>P. M.</given-names></name></person-group><article-title>Short-term clinical and microbiological evaluations of peri-implant diseases before and after mechanical anti-infective therapies</article-title><source><italic>Clinical Oral Implants Research</italic></source><year>2009</year><volume>20</volume><issue>1</issue><fpage>99</fpage><lpage>108</lpage><pub-id pub-id-type="other">2-s2.0-58149166420</pub-id><pub-id pub-id-type="doi">10.1111/j.1600-0501.2008.01618.x</pub-id><pub-id pub-id-type="pmid">19126114</pub-id></element-citation></ref><ref id="B55"><label>55</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Duarte</surname><given-names>P. M.</given-names></name><name><surname>de Mendonça</surname><given-names>A. C.</given-names></name><name><surname>Máximo</surname><given-names>M. B. B.</given-names></name><name><surname>Santos</surname><given-names>V. R.</given-names></name><name><surname>Bastos</surname><given-names>M. F.</given-names></name><name><surname>Nociti</surname><given-names>F. H.</given-names><suffix>Jr.</suffix></name></person-group><article-title>Effect of anti-infective mechanical therapy on clinical parameters and cytokine levels in human peri-implant diseases</article-title><source><italic>Journal of Periodontology</italic></source><year>2009</year><volume>80</volume><issue>2</issue><fpage>234</fpage><lpage>243</lpage><pub-id pub-id-type="other">2-s2.0-59649103697</pub-id><pub-id pub-id-type="doi">10.1902/jop.2009.070672</pub-id><pub-id pub-id-type="pmid">19186963</pub-id></element-citation></ref><ref id="B56"><label>56</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>de Waal</surname><given-names>Y. C. M.</given-names></name><name><surname>Raghoebar</surname><given-names>G. M.</given-names></name><name><surname>Huddleston Slater</surname><given-names>J. J. R.</given-names></name><name><surname>Meijer</surname><given-names>H. J. A.</given-names></name><name><surname>Winkel</surname><given-names>E. G.</given-names></name><name><surname>van Winkelhoff</surname><given-names>A. J.</given-names></name></person-group><article-title>Implant decontamination during surgical peri-implantitis treatment: a randomized, double-blind, placebo-controlled trial</article-title><source><italic>Journal of Clinical Periodontology</italic></source><year>2013</year><volume>40</volume><issue>2</issue><fpage>186</fpage><lpage>195</lpage><pub-id pub-id-type="other">2-s2.0-84872266180</pub-id><pub-id pub-id-type="doi">10.1111/jcpe.12034</pub-id><pub-id pub-id-type="pmid">23211012</pub-id></element-citation></ref><ref id="B57"><label>57</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Serino</surname><given-names>G.</given-names></name><name><surname>Turri</surname><given-names>A.</given-names></name></person-group><article-title>Outcome of surgical treatment of peri-implantitis: results from a 2-year prospective clinical study in humans</article-title><source><italic>Clinical Oral Implants Research</italic></source><year>2011</year><volume>22</volume><issue>11</issue><fpage>1214</fpage><lpage>1220</lpage><pub-id pub-id-type="other">2-s2.0-79960375573</pub-id><pub-id pub-id-type="doi">10.1111/j.1600-0501.2010.02098.x</pub-id><pub-id pub-id-type="pmid">21309860</pub-id></element-citation></ref><ref id="B58"><label>58</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Grunder</surname><given-names>U.</given-names></name><name><surname>Hürzeler</surname><given-names>M. B.</given-names></name><name><surname>Schüpbach</surname><given-names>P.</given-names></name><name><surname>Strub</surname><given-names>J. R.</given-names></name></person-group><article-title>Treatment of ligature-induced peri-implantitis using guided tissue regeneration: a clinical and histologic study in the beagle dog</article-title><source><italic>The International Journal of Oral & Maxillofacial Implants</italic></source><year>1993</year><volume>8</volume><issue>3</issue><fpage>282</fpage><lpage>293</lpage><pub-id pub-id-type="other">2-s2.0-0027356525</pub-id><pub-id pub-id-type="pmid">8225463</pub-id></element-citation></ref><ref id="B59"><label>59</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Nociti</surname><given-names>F. H.</given-names><suffix>Jr.</suffix></name><name><surname>Machado</surname><given-names>M. Â. N.</given-names></name><name><surname>Stefani</surname><given-names>C. M.</given-names></name><name><surname>Sallum</surname><given-names>E. A.</given-names></name></person-group><article-title>Absorbable versus nonabsorbable membranes and bone grafts in the treatment of ligature-induced peri-implantitis defects in dogs: a histometric investigation</article-title><source><italic>The International Journal of Oral & Maxillofacial Implants</italic></source><year>2001</year><volume>16</volume><issue>5</issue><fpage>646</fpage><lpage>652</lpage><pub-id pub-id-type="other">2-s2.0-0035464457</pub-id><pub-id pub-id-type="pmid">11669246</pub-id></element-citation></ref><ref id="B60"><label>60</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Hürzeler</surname><given-names>M. B.</given-names></name><name><surname>Quiñoncs</surname><given-names>C. R.</given-names></name><name><surname>Schüpback</surname><given-names>P.</given-names></name><name><surname>Morrison</surname><given-names>E. C.</given-names></name><name><surname>Caffesse</surname><given-names>R. G.</given-names></name></person-group><article-title>Treatment of peri-implantitis using guided bone regeneration and bone grafts, alone or in combination, in beagle dogs—part 2: histologic findings</article-title><source><italic>The International Journal of Oral & Maxillofacial Implants</italic></source><year>1997</year><volume>12</volume><issue>2</issue><fpage>168</fpage><lpage>175</lpage><pub-id pub-id-type="other">2-s2.0-0031090424</pub-id><pub-id pub-id-type="pmid">9109266</pub-id></element-citation></ref><ref id="B61"><label>61</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Roos-Jansåker</surname><given-names>A.-M.</given-names></name><name><surname>Renvert</surname><given-names>H.</given-names></name><name><surname>Lindahl</surname><given-names>C.</given-names></name><name><surname>Renvert</surname><given-names>S.</given-names></name></person-group><article-title>Surgical treatment of peri-implantitis using a bone substitute with or without a resorbable membrane: a prospective cohort study</article-title><source><italic>Journal of Clinical Periodontology</italic></source><year>2007</year><volume>34</volume><issue>7</issue><fpage>625</fpage><lpage>632</lpage><pub-id pub-id-type="other">2-s2.0-34250009032</pub-id><pub-id pub-id-type="doi">10.1111/j.1600-051X.2007.01102.x</pub-id><pub-id pub-id-type="pmid">17555414</pub-id></element-citation></ref><ref id="B62"><label>62</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Roos-Jansåker</surname><given-names>A.-M.</given-names></name><name><surname>Lindahl</surname><given-names>C.</given-names></name><name><surname>Persson</surname><given-names>G. R.</given-names></name><name><surname>Renvert</surname><given-names>S.</given-names></name></person-group><article-title>Long-term stability of surgical bone regenerative procedures of peri-implantitis lesions in a prospective case-control study over 3 years</article-title><source><italic>Journal of Clinical Periodontology</italic></source><year>2011</year><volume>38</volume><issue>6</issue><fpage>590</fpage><lpage>597</lpage><pub-id pub-id-type="other">2-s2.0-79955906122</pub-id><pub-id pub-id-type="doi">10.1111/j.1600-051X.2011.01729.x</pub-id><pub-id pub-id-type="pmid">21488935</pub-id></element-citation></ref><ref id="B63"><label>63</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Aghazadeh</surname><given-names>A.</given-names></name><name><surname>Rutger Persson</surname><given-names>G.</given-names></name><name><surname>Renvert</surname><given-names>S.</given-names></name></person-group><article-title>A single-centre randomized controlled clinical trial on the adjunct treatment of intra-bony defects with autogenous bone or a xenograft: results after 12 months</article-title><source><italic>Journal of Clinical Periodontology</italic></source><year>2012</year><volume>39</volume><issue>7</issue><fpage>666</fpage><lpage>673</lpage><pub-id pub-id-type="other">2-s2.0-84862772635</pub-id><pub-id pub-id-type="doi">10.1111/j.1600-051X.2012.01880.x</pub-id><pub-id pub-id-type="pmid">22548359</pub-id></element-citation></ref><ref id="B64"><label>64</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Wiltfang</surname><given-names>J.</given-names></name><name><surname>Zernial</surname><given-names>O.</given-names></name><name><surname>Behrens</surname><given-names>E.</given-names></name><name><surname>Schlegel</surname><given-names>A.</given-names></name><name><surname>Warnke</surname><given-names>P. H.</given-names></name><name><surname>Becker</surname><given-names>S. T.</given-names></name></person-group><article-title>Regenerative treatment of peri-implantitis bone defects with a combination of autologous bone and a demineralized xenogenic bone graft: a series of 36 defects</article-title><source><italic>Clinical Implant Dentistry and Related Research</italic></source><year>2012</year><volume>14</volume><issue>3</issue><fpage>421</fpage><lpage>427</lpage><pub-id pub-id-type="other">2-s2.0-84861819509</pub-id><pub-id pub-id-type="doi">10.1111/j.1708-8208.2009.00264.x</pub-id><pub-id pub-id-type="pmid">20132246</pub-id></element-citation></ref><ref id="B65"><label>65</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Schwarz</surname><given-names>F.</given-names></name><name><surname>Sculean</surname><given-names>A.</given-names></name><name><surname>Bieling</surname><given-names>K.</given-names></name><name><surname>Ferrari</surname><given-names>D.</given-names></name><name><surname>Rothamel</surname><given-names>D.</given-names></name><name><surname>Becker</surname><given-names>J.</given-names></name></person-group><article-title>Two-year clinical results following treatment of peri-implantitis lesions using a nanocrystalline hydroxyapatite or a natural bone mineral in combination with a collagen membrane</article-title><source><italic>Journal of Clinical Periodontology</italic></source><year>2008</year><volume>35</volume><issue>1</issue><fpage>80</fpage><lpage>87</lpage><pub-id pub-id-type="other">2-s2.0-37349054104</pub-id><pub-id pub-id-type="doi">10.1111/j.1600-051X.2007.01168.x</pub-id><pub-id pub-id-type="pmid">18173402</pub-id></element-citation></ref><ref id="B66"><label>66</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Sahrmann</surname><given-names>P.</given-names></name><name><surname>Attin</surname><given-names>T.</given-names></name><name><surname>Schmidlin</surname><given-names>P. R.</given-names></name></person-group><article-title>Regenerative treatment of peri-implantitis using bone substitutes and membrane: a systematic review</article-title><source><italic>Clinical Implant Dentistry and Related Research</italic></source><year>2011</year><volume>13</volume><issue>1</issue><fpage>46</fpage><lpage>57</lpage><pub-id pub-id-type="other">2-s2.0-79551531027</pub-id><pub-id pub-id-type="doi">10.1111/j.1708-8208.2009.00183.x</pub-id><pub-id pub-id-type="pmid">19681931</pub-id></element-citation></ref><ref id="B67"><label>67</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Schwarz</surname><given-names>F.</given-names></name><name><surname>Sahm</surname><given-names>N.</given-names></name><name><surname>Schwarz</surname><given-names>K.</given-names></name><name><surname>Becker</surname><given-names>J.</given-names></name></person-group><article-title>Impact of defect configuration on the clinical outcome following surgical regenerative therapy of peri-implantitis</article-title><source><italic>Journal of Clinical Periodontology</italic></source><year>2010</year><volume>37</volume><issue>5</issue><fpage>449</fpage><lpage>455</lpage><pub-id pub-id-type="other">2-s2.0-77950634202</pub-id><pub-id pub-id-type="doi">10.1111/j.1600-051X.2010.01540.x</pub-id><pub-id pub-id-type="pmid">20374416</pub-id></element-citation></ref><ref id="B68"><label>68</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Froum</surname><given-names>S. J.</given-names></name><name><surname>Froum</surname><given-names>S. H.</given-names></name><name><surname>Rosen</surname><given-names>P. S.</given-names></name></person-group><article-title>Successful management of peri-implantitis with a regenerative approach: a consecutive series of 51 treated implants with 3- to 7.5-year follow-up</article-title><source><italic>The International Journal of Periodontics & Restorative Dentistry</italic></source><year>2012</year><volume>32</volume><issue>1</issue><fpage>11</fpage><lpage>20</lpage><pub-id pub-id-type="other">2-s2.0-84862280649</pub-id><pub-id pub-id-type="pmid">22254219</pub-id></element-citation></ref><ref id="B69"><label>69</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Roccuzzo</surname><given-names>M.</given-names></name><name><surname>Bonino</surname><given-names>F.</given-names></name><name><surname>Bonino</surname><given-names>L.</given-names></name><name><surname>Dalmasso</surname><given-names>P.</given-names></name></person-group><article-title>Surgical therapy of peri-implantitis lesions by means of a bovine-derived xenograft: comparative results of a prospective study on two different implant surfaces</article-title><source><italic>Journal of Clinical Periodontology</italic></source><year>2011</year><volume>38</volume><issue>8</issue><fpage>738</fpage><lpage>745</lpage><pub-id pub-id-type="other">2-s2.0-79960367652</pub-id><pub-id pub-id-type="doi">10.1111/j.1600-051X.2011.01742.x</pub-id><pub-id pub-id-type="pmid">21635278</pub-id></element-citation></ref><ref id="B70"><label>70</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Roos-Jansåker</surname><given-names>A.-M.</given-names></name><name><surname>Renvert</surname><given-names>H.</given-names></name><name><surname>Lindahl</surname><given-names>C.</given-names></name><name><surname>Renvert</surname><given-names>S.</given-names></name></person-group><article-title>Submerged healing following surgical treatment of peri-implantitis: a case series</article-title><source><italic>Journal of Clinical Periodontology</italic></source><year>2007</year><volume>34</volume><issue>8</issue><fpage>723</fpage><lpage>727</lpage><pub-id pub-id-type="other">2-s2.0-34547167857</pub-id><pub-id pub-id-type="doi">10.1111/j.1600-051X.2007.01098.x</pub-id><pub-id pub-id-type="pmid">17535286</pub-id></element-citation></ref><ref id="B71"><label>71</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Schwarz</surname><given-names>F.</given-names></name><name><surname>Jepsen</surname><given-names>S.</given-names></name><name><surname>Herten</surname><given-names>M.</given-names></name><name><surname>Sager</surname><given-names>M.</given-names></name><name><surname>Rothamel</surname><given-names>D.</given-names></name><name><surname>Becker</surname><given-names>J.</given-names></name></person-group><article-title>Influence of different treatment approaches on non-submerged and submerged healing of ligature induced peri-implantitis lesions: an experimental study in dogs</article-title><source><italic>Journal of Clinical Periodontology</italic></source><year>2006</year><volume>33</volume><issue>8</issue><fpage>584</fpage><lpage>595</lpage><pub-id pub-id-type="other">2-s2.0-33746267218</pub-id><pub-id pub-id-type="doi">10.1111/j.1600-051X.2006.00956.x</pub-id><pub-id pub-id-type="pmid">16899102</pub-id></element-citation></ref><ref id="B72"><label>72</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Wohlfahrt</surname><given-names>J. C.</given-names></name><name><surname>Lyngstadaas</surname><given-names>S. P.</given-names></name><name><surname>Rønold</surname><given-names>H. J.</given-names></name><etal></etal></person-group><article-title>Porous titanium granules in the surgical treatment of peri-implant osseous defects: a randomized clinical trial</article-title><source><italic>The International Journal of Oral & Maxillofacial Implants</italic></source><year>2012</year><volume>27</volume><issue>2</issue><fpage>401</fpage><lpage>410</lpage><pub-id pub-id-type="other">2-s2.0-84873052129</pub-id><pub-id pub-id-type="pmid">22442781</pub-id></element-citation></ref><ref id="B73"><label>73</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Gamal</surname><given-names>A. Y.</given-names></name><name><surname>Abdel-Ghaffar</surname><given-names>K. A.</given-names></name><name><surname>Iacono</surname><given-names>V. J.</given-names></name></person-group><article-title>A novel approach for enhanced nanoparticle-sized bone substitute adhesion to chemically treated peri-implantitis-affected implant surfaces: an in vitro proof-of-principle study</article-title><source><italic>Journal of Periodontology</italic></source><year>2013</year><volume>84</volume><issue>2</issue><fpage>239</fpage><lpage>247</lpage><pub-id pub-id-type="other">2-s2.0-84873528962</pub-id><pub-id pub-id-type="doi">10.1902/jop.2012.120023</pub-id><pub-id pub-id-type="pmid">22554294</pub-id></element-citation></ref><ref id="B74"><label>74</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Schwarz</surname><given-names>F.</given-names></name><name><surname>Bieling</surname><given-names>K.</given-names></name><name><surname>Latz</surname><given-names>T.</given-names></name><name><surname>Nuesry</surname><given-names>E.</given-names></name><name><surname>Becker</surname><given-names>J.</given-names></name></person-group><article-title>Healing of intrabony peri-implantitis defects following application of a nanocrystalline hydroxyapatite (Ostim) or a bovine-derived xenograft (Bio-Oss) in combination with a collagen membrane (Bio-Gide). A case series</article-title><source><italic>Journal of Clinical Periodontology</italic></source><year>2006</year><volume>33</volume><issue>7</issue><fpage>491</fpage><lpage>499</lpage><pub-id pub-id-type="other">2-s2.0-33745378073</pub-id><pub-id pub-id-type="doi">10.1111/j.1600-051X.2006.00936.x</pub-id><pub-id pub-id-type="pmid">16820037</pub-id></element-citation></ref><ref id="B75"><label>75</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Baron</surname><given-names>M.</given-names></name><name><surname>Haas</surname><given-names>R.</given-names></name><name><surname>Dörtbudak</surname><given-names>O.</given-names></name><name><surname>Watzek</surname><given-names>G.</given-names></name></person-group><article-title>Experimentally induced peri-implantitis: a review of different treatment methods described in the literature</article-title><source><italic>The International Journal of Oral & Maxillofacial Implants</italic></source><year>2000</year><volume>15</volume><issue>4</issue><fpage>533</fpage><lpage>544</lpage><pub-id pub-id-type="other">2-s2.0-0034220256</pub-id><pub-id pub-id-type="pmid">10960987</pub-id></element-citation></ref><ref id="B76"><label>76</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Roos-Jansåker</surname><given-names>A.-M.</given-names></name></person-group><article-title>Long time follow up of implant therapy and treatment of peri-implantitis</article-title><source><italic>Swedish Dental Journal. Supplement</italic></source><year>2007</year><issue>188</issue><fpage>7</fpage><lpage>66</lpage><pub-id pub-id-type="other">2-s2.0-34948814116</pub-id><pub-id pub-id-type="pmid">17694834</pub-id></element-citation></ref><ref id="B77"><label>77</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Romanos</surname><given-names>G. E.</given-names></name><name><surname>Nentwig</surname><given-names>G. H.</given-names></name></person-group><article-title>Regenerative therapy of deep peri-implant lnfrabony defects after CO<sub>2</sub> laser implant surface decontamination</article-title><source><italic>International Journal of Periodontics and Restorative Dentistry</italic></source><year>2008</year><volume>28</volume><issue>3</issue><fpage>245</fpage><lpage>255</lpage><pub-id pub-id-type="other">2-s2.0-46149086571</pub-id><pub-id pub-id-type="pmid">18605600</pub-id></element-citation></ref><ref id="B78"><label>78</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Schou</surname><given-names>S.</given-names></name><name><surname>Holmstrup</surname><given-names>P.</given-names></name><name><surname>Jørgensen</surname><given-names>T.</given-names></name><etal></etal></person-group><article-title>Anorganic porous bovine-derived bone mineral (Bio-Oss) and ePTFE membrane in the treatment of peri-implantitis in cynomolgus monkeys</article-title><source><italic>Clinical Oral Implants Research</italic></source><year>2003</year><volume>14</volume><issue>5</issue><fpage>535</fpage><lpage>547</lpage><pub-id pub-id-type="other">2-s2.0-0345715006</pub-id><pub-id pub-id-type="doi">10.1034/j.1600-0501.2003.00911.x</pub-id><pub-id pub-id-type="pmid">12969357</pub-id></element-citation></ref><ref id="B79"><label>79</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Schou</surname><given-names>S.</given-names></name><name><surname>Holmstrup</surname><given-names>P.</given-names></name><name><surname>Skovgaard</surname><given-names>L. T.</given-names></name><name><surname>Stoltze</surname><given-names>K.</given-names></name><name><surname>Hjørting-Hansen</surname><given-names>E.</given-names></name><name><surname>Gundersen</surname><given-names>H. J. G.</given-names></name></person-group><article-title>Autogenous bone graft and ePTFE membrane in the treatment of peri-implantitis. II. Stereologic and histologic observations in cynomolgus monkeys</article-title><source><italic>Clinical Oral Implants Research</italic></source><year>2003</year><volume>14</volume><issue>4</issue><fpage>404</fpage><lpage>411</lpage><pub-id pub-id-type="other">2-s2.0-0141497397</pub-id><pub-id pub-id-type="doi">10.1034/j.1600-0501.2003.120910.x</pub-id><pub-id pub-id-type="pmid">12869002</pub-id></element-citation></ref><ref id="B80"><label>80</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Schou</surname><given-names>S.</given-names></name><name><surname>Holmstrup</surname><given-names>P.</given-names></name><name><surname>Jørgensen</surname><given-names>T.</given-names></name><etal></etal></person-group><article-title>Implant surface preparation in the surgical treatment of experimental peri-implantitis with autogenous bone graft and ePTFE membrane in cynomolgus monkeys</article-title><source><italic>Clinical Oral Implants Research</italic></source><year>2003</year><volume>14</volume><issue>4</issue><fpage>412</fpage><lpage>422</lpage><pub-id pub-id-type="other">2-s2.0-0141609016</pub-id><pub-id pub-id-type="doi">10.1034/j.1600-0501.2003.00912.x</pub-id><pub-id pub-id-type="pmid">12869003</pub-id></element-citation></ref><ref id="B81"><label>81</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Khoshkam</surname><given-names>V.</given-names></name><name><surname>Chan</surname><given-names>H.</given-names></name><name><surname>Lin</surname><given-names>G.</given-names></name><etal></etal></person-group><article-title>Reconstructive procedures for treating peri-implantitis: a systematic review</article-title><source><italic>Journal of Dental Research</italic></source><year>2013</year><volume>92</volume><issue>12, supplement</issue><fpage>131S</fpage><lpage>138S</lpage><pub-id pub-id-type="doi">10.1177/0022034513509279</pub-id><pub-id pub-id-type="pmid">24158331</pub-id></element-citation></ref><ref id="B82"><label>82</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Heitz-Mayfield</surname><given-names>L. J. A.</given-names></name><name><surname>Salvi</surname><given-names>G. E.</given-names></name><name><surname>Mombelli</surname><given-names>A.</given-names></name><name><surname>Faddy</surname><given-names>M.</given-names></name><name><surname>Lang</surname><given-names>N. P.</given-names></name></person-group><article-title>Anti-infective surgical therapy of peri-implantitis. A 12-month prospective clinical study</article-title><source><italic>Clinical Oral Implants Research</italic></source><year>2012</year><volume>23</volume><issue>2</issue><fpage>205</fpage><lpage>210</lpage><pub-id pub-id-type="other">2-s2.0-84855919545</pub-id><pub-id pub-id-type="doi">10.1111/j.1600-0501.2011.02276.x</pub-id><pub-id pub-id-type="pmid">22092831</pub-id></element-citation></ref><ref id="B83"><label>83</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Leonhardt</surname><given-names>Å.</given-names></name><name><surname>Dahlén</surname><given-names>G.</given-names></name><name><surname>Renvert</surname><given-names>S.</given-names></name></person-group><article-title>Five-year clinical, microbiological, and radiological outcome following treatment of peri-implantitis in man</article-title><source><italic>Journal of Periodontology</italic></source><year>2003</year><volume>74</volume><issue>10</issue><fpage>1415</fpage><lpage>1422</lpage><pub-id pub-id-type="other">2-s2.0-0344442767</pub-id><pub-id pub-id-type="doi">10.1902/jop.2003.74.10.1415</pub-id><pub-id pub-id-type="pmid">14653386</pub-id></element-citation></ref><ref id="B84"><label>84</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Charalampakis</surname><given-names>G.</given-names></name><name><surname>Rabe</surname><given-names>P.</given-names></name><name><surname>Leonhardt</surname><given-names>Å.</given-names></name><name><surname>Dahlén</surname><given-names>G.</given-names></name></person-group><article-title>A follow-up study of peri-implantitis cases after treatment</article-title><source><italic>Journal of Clinical Periodontology</italic></source><year>2011</year><volume>38</volume><issue>9</issue><fpage>864</fpage><lpage>871</lpage><pub-id pub-id-type="other">2-s2.0-80051783552</pub-id><pub-id pub-id-type="doi">10.1111/j.1600-051X.2011.01759.x</pub-id><pub-id pub-id-type="pmid">21770994</pub-id></element-citation></ref><ref id="B85"><label>85</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Horvath</surname><given-names>S. D.</given-names></name><name><surname>Kohal</surname><given-names>R. J.</given-names></name></person-group><article-title>Rehabilitation of an extensive anterior explantation defect—a case report</article-title><source><italic>Quintessence International</italic></source><year>2011</year><volume>42</volume><issue>7</issue><fpage>539</fpage><lpage>545</lpage><pub-id pub-id-type="other">2-s2.0-80155198564</pub-id><pub-id pub-id-type="pmid">21716981</pub-id></element-citation></ref><ref id="B86"><label>86</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Machtei</surname><given-names>E. E.</given-names></name></person-group><article-title>What do we do after an implant fails? A review of treatment alternatives for failed implants</article-title><source><italic>The International Journal of Periodontics & Restorative Dentistry</italic></source><year>2013</year><volume>33</volume><issue>4</issue><fpage>e111</fpage><lpage>e119</lpage><pub-id pub-id-type="doi">10.11607/prd.1505</pub-id><pub-id pub-id-type="pmid">23820700</pub-id></element-citation></ref><ref id="B87"><label>87</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Manzoor</surname><given-names>B.</given-names></name><name><surname>Suleiman</surname><given-names>M.</given-names></name><name><surname>Palmer</surname><given-names>R. M.</given-names></name></person-group><article-title>The effects of simulated bone loss on the implant-abutment assembly and likelihood of fracture: an in vitro study</article-title><source><italic>The International Journal of Oral & Maxillofacial Implants</italic></source><year>2013</year><volume>28</volume><issue>3</issue><fpage>729</fpage><lpage>738</lpage><pub-id pub-id-type="doi">10.11607/jomi.2819</pub-id><pub-id pub-id-type="pmid">23748303</pub-id></element-citation></ref><ref id="B88"><label>88</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Kolonidis</surname><given-names>S. G.</given-names></name><name><surname>Renvert</surname><given-names>S.</given-names></name><name><surname>Hämmerle</surname><given-names>C. H. F.</given-names></name><name><surname>Lang</surname><given-names>N. P.</given-names></name><name><surname>Harris</surname><given-names>D.</given-names></name><name><surname>Claffey</surname><given-names>N.</given-names></name></person-group><article-title>Osseointegration on implant surfaces previously contaminated with plaque: an experimental study in the dog</article-title><source><italic>Clinical Oral Implants Research</italic></source><year>2003</year><volume>14</volume><issue>4</issue><fpage>373</fpage><lpage>380</lpage><pub-id pub-id-type="other">2-s2.0-0141832059</pub-id><pub-id pub-id-type="doi">10.1034/j.1600-0501.2003.01871.x</pub-id><pub-id pub-id-type="pmid">12868999</pub-id></element-citation></ref><ref id="B89"><label>89</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Horvath</surname><given-names>S. D.</given-names></name><name><surname>Kohal</surname><given-names>R. J.</given-names></name></person-group><article-title>Rehabilitation of an extensive anterior explantation defect—a case report</article-title><source><italic>Quintessence International</italic></source><year>2011</year><volume>42</volume><issue>7</issue><fpage>539</fpage><lpage>545</lpage><pub-id pub-id-type="other">2-s2.0-80155198564</pub-id><pub-id pub-id-type="pmid">21716981</pub-id></element-citation></ref><ref id="B90"><label>90</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Mardinger</surname><given-names>O.</given-names></name><name><surname>Oubaid</surname><given-names>S.</given-names></name><name><surname>Manor</surname><given-names>Y.</given-names></name><name><surname>Nissan</surname><given-names>J.</given-names></name><name><surname>Chaushu</surname><given-names>G.</given-names></name></person-group><article-title>Factors affecting the decision to replace failed implants: a retrospective study</article-title><source><italic>Journal of Periodontology</italic></source><year>2008</year><volume>79</volume><issue>12</issue><fpage>2262</fpage><lpage>2266</lpage><pub-id pub-id-type="other">2-s2.0-57349135271</pub-id><pub-id pub-id-type="doi">10.1902/jop.2008.080255</pub-id><pub-id pub-id-type="pmid">19053915</pub-id></element-citation></ref><ref id="B91"><label>91</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Alsaadi</surname><given-names>G.</given-names></name><name><surname>Quirynen</surname><given-names>M.</given-names></name><name><surname>van Steenberghe</surname><given-names>D.</given-names></name></person-group><article-title>The importance of implant surface characteristics in the replacement of failed implants</article-title><source><italic>The International Journal of Oral & Maxillofacial Implants</italic></source><year>2006</year><volume>21</volume><issue>2</issue><fpage>270</fpage><lpage>274</lpage><pub-id pub-id-type="other">2-s2.0-33646231742</pub-id><pub-id pub-id-type="pmid">16634498</pub-id></element-citation></ref><ref id="B92"><label>92</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Grossmann</surname><given-names>Y.</given-names></name><name><surname>Levin</surname><given-names>L.</given-names></name></person-group><article-title>Success and survival of single dental implants placed in sites of previously failed implants</article-title><source><italic>Journal of Periodontology</italic></source><year>2007</year><volume>78</volume><issue>9</issue><fpage>1670</fpage><lpage>1674</lpage><pub-id pub-id-type="other">2-s2.0-34748910618</pub-id><pub-id pub-id-type="doi">10.1902/jop.2007.060516</pub-id><pub-id pub-id-type="pmid">17760534</pub-id></element-citation></ref><ref id="B93"><label>93</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Machtei</surname><given-names>E. E.</given-names></name><name><surname>Mahler</surname><given-names>D.</given-names></name><name><surname>Oettinger-Barak</surname><given-names>O.</given-names></name><name><surname>Zuabi</surname><given-names>O.</given-names></name><name><surname>Horwitz</surname><given-names>J.</given-names></name></person-group><article-title>Dental implants placed in previously failed sites: survival rate and factors affecting the outcome</article-title><source><italic>Clinical Oral Implants Research</italic></source><year>2008</year><volume>19</volume><issue>3</issue><fpage>259</fpage><lpage>264</lpage><pub-id pub-id-type="other">2-s2.0-38549099515</pub-id><pub-id pub-id-type="doi">10.1111/j.1600-0501.2007.01466.x</pub-id><pub-id pub-id-type="pmid">18177430</pub-id></element-citation></ref><ref id="B94"><label>94</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Kim</surname><given-names>Y.-K.</given-names></name><name><surname>Park</surname><given-names>J.-Y.</given-names></name><name><surname>Kim</surname><given-names>S.-G.</given-names></name><name><surname>Lee</surname><given-names>H.-J.</given-names></name></person-group><article-title>Prognosis of the implants replaced after removal of failed dental implants</article-title><source><italic>Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology and Endodontology</italic></source><year>2010</year><volume>110</volume><issue>3</issue><fpage>281</fpage><lpage>286</lpage><pub-id pub-id-type="other">2-s2.0-77955927592</pub-id><pub-id pub-id-type="doi">10.1016/j.tripleo.2010.01.031</pub-id></element-citation></ref><ref id="B95"><label>95</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Mardinger</surname><given-names>O.</given-names></name><name><surname>Ben Zvi</surname><given-names>Y.</given-names></name><name><surname>Chaushu</surname><given-names>G.</given-names></name><name><surname>Nissan</surname><given-names>J.</given-names></name><name><surname>Manor</surname><given-names>Y.</given-names></name></person-group><article-title>A retrospective analysis of replacing dental implants in previously failed sites</article-title><source><italic>Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology</italic></source><year>2012</year><volume>114</volume><issue>3</issue><fpage>290</fpage><lpage>293</lpage><pub-id pub-id-type="other">2-s2.0-84864602458</pub-id><pub-id pub-id-type="doi">10.1016/j.tripleo.2011.07.010</pub-id></element-citation></ref><ref id="B96"><label>96</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Eliasson</surname><given-names>A.</given-names></name><name><surname>Eriksson</surname><given-names>T.</given-names></name><name><surname>Johansson</surname><given-names>A.</given-names></name><name><surname>Wennerberg</surname><given-names>A.</given-names></name></person-group><article-title>Fixed partial prostheses supported by 2 or 3 implants: a retrospective study up to 18 years</article-title><source><italic>The International Journal of Oral & Maxillofacial Implants</italic></source><year>2006</year><volume>21</volume><issue>4</issue><fpage>567</fpage><lpage>574</lpage><pub-id pub-id-type="other">2-s2.0-33748550640</pub-id><pub-id pub-id-type="pmid">16955607</pub-id></element-citation></ref><ref id="B97"><label>97</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Salvi</surname><given-names>G. E.</given-names></name><name><surname>Brägger</surname><given-names>U.</given-names></name></person-group><article-title>Mechanical and technical risks in implant therapy</article-title><source><italic>The International Journal of Oral & Maxillofacial Implants</italic></source><year>2009</year><volume>24</volume><issue>supplement</issue><fpage>69</fpage><lpage>85</lpage><pub-id pub-id-type="other">2-s2.0-75549084256</pub-id><pub-id pub-id-type="pmid">19885435</pub-id></element-citation></ref><ref id="B98"><label>98</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Pjetursson</surname><given-names>B. E.</given-names></name><name><surname>Brägger</surname><given-names>U.</given-names></name><name><surname>Lang</surname><given-names>N. P.</given-names></name><name><surname>Zwahlen</surname><given-names>M.</given-names></name></person-group><article-title>Comparison of survival and complication rates of tooth-supported fixed dental prostheses (FDPs) and implant-supported FDPs and single crowns (SCs)</article-title><source><italic>Clinical Oral Implants Research</italic></source><year>2007</year><volume>18</volume><issue>supplement 3</issue><fpage>97</fpage><lpage>113</lpage><pub-id pub-id-type="other">2-s2.0-34250625230</pub-id><pub-id pub-id-type="doi">10.1111/j.1600-0501.2007.01439.x</pub-id><pub-id pub-id-type="pmid">17594374</pub-id></element-citation></ref><ref id="B99"><label>99</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Weber</surname><given-names>H.-P.</given-names></name><name><surname>Sukotjo</surname><given-names>C.</given-names></name></person-group><article-title>Does the type of implant prosthesis affect outcomes in the partially edentulous patient?</article-title><source><italic>The International Journal of Oral & Maxillofacial Implants</italic></source><year>2007</year><volume>22</volume><issue>supplement</issue><fpage>140</fpage><lpage>172</lpage><pub-id pub-id-type="other">2-s2.0-33847768640</pub-id><pub-id pub-id-type="pmid">18437795</pub-id></element-citation></ref><ref id="B100"><label>100</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Lang</surname><given-names>N. P.</given-names></name><name><surname>Pjetursson</surname><given-names>B. E.</given-names></name><name><surname>Tan</surname><given-names>K.</given-names></name><name><surname>Brägger</surname><given-names>U.</given-names></name><name><surname>Egger</surname><given-names>M.</given-names></name><name><surname>Zwahlen</surname><given-names>M.</given-names></name></person-group><article-title>A systematic review of the survival and complication rates of fixed partial dentures (FPDs) after an observation period of at least 5 years: II. Combined tooth-implant-supported FPDs</article-title><source><italic>Clinical Oral Implants Research</italic></source><year>2004</year><volume>15</volume><issue>6</issue><fpage>643</fpage><lpage>653</lpage><pub-id pub-id-type="other">2-s2.0-12244251465</pub-id><pub-id pub-id-type="doi">10.1111/j.1600-0501.2004.01118.x</pub-id><pub-id pub-id-type="pmid">15533125</pub-id></element-citation></ref><ref id="B101"><label>101</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Nickenig</surname><given-names>H.-J.</given-names></name><name><surname>Schäfer</surname><given-names>C.</given-names></name><name><surname>Spiekermann</surname><given-names>H.</given-names></name></person-group><article-title>Survival and complication rates of combined tooth-implant-supported fixed partial dentures</article-title><source><italic>Clinical Oral Implants Research</italic></source><year>2006</year><volume>17</volume><issue>5</issue><fpage>506</fpage><lpage>511</lpage><pub-id pub-id-type="other">2-s2.0-33748366361</pub-id><pub-id pub-id-type="doi">10.1111/j.1600-0501.2006.01259.x</pub-id><pub-id pub-id-type="pmid">16958689</pub-id></element-citation></ref><ref id="B102"><label>102</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Hita-Carrillo</surname><given-names>C.</given-names></name><name><surname>Hernández-Aliaga</surname><given-names>M.</given-names></name><name><surname>Calvo-Guirado</surname><given-names>J.-L.</given-names></name></person-group><article-title>Tooth-implant connection: a bibliographic review</article-title><source><italic>Medicina Oral, Patologia Oral y Cirugia Bucal</italic></source><year>2010</year><volume>15</volume><issue>2</issue><fpage>e387</fpage><lpage>e394</lpage><pub-id pub-id-type="other">2-s2.0-77749289115</pub-id><pub-id pub-id-type="doi">10.4317/medoral.15.e387</pub-id></element-citation></ref><ref id="B103"><label>103</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Tonetti</surname><given-names>M.</given-names></name><name><surname>Palmer</surname><given-names>R.</given-names></name></person-group><article-title>Clinical research in implant dentistry: study design, reporting and outcome measurements: consensus report of Working Group 2 of the VIII European Workshop on Periodontology</article-title><source><italic>Journal of Clinical Periodontology</italic></source><year>2012</year><volume>39</volume><issue>12</issue><fpage>73</fpage><lpage>80</lpage><pub-id pub-id-type="other">2-s2.0-84858025531</pub-id><pub-id pub-id-type="doi">10.1111/j.1600-051X.2011.01843.x</pub-id><pub-id pub-id-type="pmid">22533948</pub-id></element-citation></ref><ref id="B104"><label>104</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Esposito</surname><given-names>M.</given-names></name><name><surname>Grusovin</surname><given-names>M. G.</given-names></name><name><surname>Worthington</surname><given-names>H. V.</given-names></name></person-group><article-title>Treatment of peri-implantitis: what interventions are effective? A Cochrane systematic review</article-title><source><italic>European Journal of Oral Implantology</italic></source><year>2012</year><volume>5</volume><issue>supplement</issue><fpage>S21</fpage><lpage>S41</lpage><pub-id pub-id-type="other">2-s2.0-84864871746</pub-id><pub-id pub-id-type="pmid">22834392</pub-id></element-citation></ref></ref-list></back><floats-group><fig id="fig1" orientation="portrait" position="float"><label>Figure 1</label><caption><p>Peri-implantitis with suppuration.</p></caption><graphic xlink:href="AMED2014-487903.001"></graphic></fig><fig id="fig2" orientation="portrait" position="float"><label>Figure 2</label><caption><p>Treatment of peri-implantitis using a regenerative approach. (a) Preop, note the severe bone loss on implant at position #14. (b) Upon reflection of the flaps, note the granulation tissue but also excess cementum on the crown's margin. (c) Following degranulation, demonstrating the extent of bone loss. (d) Excess cement was removed and the implant surface was debrided using hand instruments and ultrasonic scaler. (e) Decortication was performed using diamond burs. (f) Surface decontamination was supplemented with the application of 24% EDTA for 3 minutes. (g) The defect was grafted with bovine derived Xenograft (BioOss). (h) 3 years later, complete resolution of the radiographic defect is evident.</p></caption><graphic xlink:href="AMED2014-487903.002"></graphic></fig><fig id="fig3" orientation="portrait" position="float"><label>Figure 3</label><caption><p>Explantation of dental implant.</p></caption><graphic xlink:href="AMED2014-487903.003"></graphic></fig></floats-group></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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|clé= PMC:4590969
|texte= Treatment Alternatives to Negotiate Peri-Implantitis
}}
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HfdIndexSelect -h $EXPLOR_AREA/Data/Pmc/Corpus/RBID.i -Sk "pubmed:26556414" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Pmc/Corpus/biblio.hfd \
| NlmPubMed2Wicri -a EdenteV2
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