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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Injectable bone substitute to preserve alveolar ridge resorption after tooth extraction: a study in dog</title><author><name sortKey="Boix, Damien" sort="Boix, Damien" uniqKey="Boix D" first="Damien" last="Boix">Damien Boix</name><affiliation><nlm:aff id="A1">Matériaux d'intérêt biologique<institution>INSERM : EPI9903</institution><institution>Université de Nantes</institution><addr-line>Faculté de chirurgie dentaire
1 place Alexis Ricordeau BP84215
44042 Nantes,FR</addr-line></nlm:aff></affiliation></author><author><name sortKey="Weiss, Pierre" sort="Weiss, Pierre" uniqKey="Weiss P" first="Pierre" last="Weiss">Pierre Weiss</name><affiliation><nlm:aff id="A1">Matériaux d'intérêt biologique<institution>INSERM : EPI9903</institution><institution>Université de Nantes</institution><addr-line>Faculté de chirurgie dentaire
1 place Alexis Ricordeau BP84215
44042 Nantes,FR</addr-line></nlm:aff></affiliation></author><author><name sortKey="Gauthier, Olivier" sort="Gauthier, Olivier" uniqKey="Gauthier O" first="Olivier" last="Gauthier">Olivier Gauthier</name><affiliation><nlm:aff id="A1">Matériaux d'intérêt biologique<institution>INSERM : EPI9903</institution><institution>Université de Nantes</institution><addr-line>Faculté de chirurgie dentaire
1 place Alexis Ricordeau BP84215
44042 Nantes,FR</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="A2">Département de chirurgie<institution>Ecole Nationale Vétérinaire de Nantes</institution><addr-line>44307 Nantes,FR</addr-line></nlm:aff></affiliation></author><author><name sortKey="Guicheux, Jerome" sort="Guicheux, Jerome" uniqKey="Guicheux J" first="Jérôme" last="Guicheux">Jérôme Guicheux</name><affiliation><nlm:aff id="A1">Matériaux d'intérêt biologique<institution>INSERM : EPI9903</institution><institution>Université de Nantes</institution><addr-line>Faculté de chirurgie dentaire
1 place Alexis Ricordeau BP84215
44042 Nantes,FR</addr-line></nlm:aff></affiliation></author><author><name sortKey="Bouler, Jean Michel" sort="Bouler, Jean Michel" uniqKey="Bouler J" first="Jean-Michel" last="Bouler">Jean-Michel Bouler</name><affiliation><nlm:aff id="A1">Matériaux d'intérêt biologique<institution>INSERM : EPI9903</institution><institution>Université de Nantes</institution><addr-line>Faculté de chirurgie dentaire
1 place Alexis Ricordeau BP84215
44042 Nantes,FR</addr-line></nlm:aff></affiliation></author><author><name sortKey="Pilet, Paul" sort="Pilet, Paul" uniqKey="Pilet P" first="Paul" last="Pilet">Paul Pilet</name><affiliation><nlm:aff id="A3">Centre de microscopie électronique<institution>CHU Nantes</institution><institution>Université de Nantes</institution><addr-line>1 place Alexis Ricordeau
44042 Nantes,FR</addr-line></nlm:aff></affiliation></author><author><name sortKey="Daculsi, Guy" sort="Daculsi, Guy" uniqKey="Daculsi G" first="Guy" last="Daculsi">Guy Daculsi</name><affiliation><nlm:aff id="A1">Matériaux d'intérêt biologique<institution>INSERM : EPI9903</institution><institution>Université de Nantes</institution><addr-line>Faculté de chirurgie dentaire
1 place Alexis Ricordeau BP84215
44042 Nantes,FR</addr-line></nlm:aff></affiliation></author><author><name sortKey="Grimandi, Gael" sort="Grimandi, Gael" uniqKey="Grimandi G" first="Gaël" last="Grimandi">Gaël Grimandi</name><affiliation><nlm:aff id="A1">Matériaux d'intérêt biologique<institution>INSERM : EPI9903</institution><institution>Université de Nantes</institution><addr-line>Faculté de chirurgie dentaire
1 place Alexis Ricordeau BP84215
44042 Nantes,FR</addr-line></nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">17122930</idno><idno type="pmc">2042990</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2042990</idno><idno type="RBID">PMC:2042990</idno><idno type="doi">10.1007/s10856-006-0542-7</idno><date when="2006">2006</date><idno type="wicri:Area/Pmc/Corpus">002798</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002798</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Injectable bone substitute to preserve alveolar ridge resorption after tooth extraction: a study in dog</title><author><name sortKey="Boix, Damien" sort="Boix, Damien" uniqKey="Boix D" first="Damien" last="Boix">Damien Boix</name><affiliation><nlm:aff id="A1">Matériaux d'intérêt biologique<institution>INSERM : EPI9903</institution><institution>Université de Nantes</institution><addr-line>Faculté de chirurgie dentaire
1 place Alexis Ricordeau BP84215
44042 Nantes,FR</addr-line></nlm:aff></affiliation></author><author><name sortKey="Weiss, Pierre" sort="Weiss, Pierre" uniqKey="Weiss P" first="Pierre" last="Weiss">Pierre Weiss</name><affiliation><nlm:aff id="A1">Matériaux d'intérêt biologique<institution>INSERM : EPI9903</institution><institution>Université de Nantes</institution><addr-line>Faculté de chirurgie dentaire
1 place Alexis Ricordeau BP84215
44042 Nantes,FR</addr-line></nlm:aff></affiliation></author><author><name sortKey="Gauthier, Olivier" sort="Gauthier, Olivier" uniqKey="Gauthier O" first="Olivier" last="Gauthier">Olivier Gauthier</name><affiliation><nlm:aff id="A1">Matériaux d'intérêt biologique<institution>INSERM : EPI9903</institution><institution>Université de Nantes</institution><addr-line>Faculté de chirurgie dentaire
1 place Alexis Ricordeau BP84215
44042 Nantes,FR</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="A2">Département de chirurgie<institution>Ecole Nationale Vétérinaire de Nantes</institution><addr-line>44307 Nantes,FR</addr-line></nlm:aff></affiliation></author><author><name sortKey="Guicheux, Jerome" sort="Guicheux, Jerome" uniqKey="Guicheux J" first="Jérôme" last="Guicheux">Jérôme Guicheux</name><affiliation><nlm:aff id="A1">Matériaux d'intérêt biologique<institution>INSERM : EPI9903</institution><institution>Université de Nantes</institution><addr-line>Faculté de chirurgie dentaire
1 place Alexis Ricordeau BP84215
44042 Nantes,FR</addr-line></nlm:aff></affiliation></author><author><name sortKey="Bouler, Jean Michel" sort="Bouler, Jean Michel" uniqKey="Bouler J" first="Jean-Michel" last="Bouler">Jean-Michel Bouler</name><affiliation><nlm:aff id="A1">Matériaux d'intérêt biologique<institution>INSERM : EPI9903</institution><institution>Université de Nantes</institution><addr-line>Faculté de chirurgie dentaire
1 place Alexis Ricordeau BP84215
44042 Nantes,FR</addr-line></nlm:aff></affiliation></author><author><name sortKey="Pilet, Paul" sort="Pilet, Paul" uniqKey="Pilet P" first="Paul" last="Pilet">Paul Pilet</name><affiliation><nlm:aff id="A3">Centre de microscopie électronique<institution>CHU Nantes</institution><institution>Université de Nantes</institution><addr-line>1 place Alexis Ricordeau
44042 Nantes,FR</addr-line></nlm:aff></affiliation></author><author><name sortKey="Daculsi, Guy" sort="Daculsi, Guy" uniqKey="Daculsi G" first="Guy" last="Daculsi">Guy Daculsi</name><affiliation><nlm:aff id="A1">Matériaux d'intérêt biologique<institution>INSERM : EPI9903</institution><institution>Université de Nantes</institution><addr-line>Faculté de chirurgie dentaire
1 place Alexis Ricordeau BP84215
44042 Nantes,FR</addr-line></nlm:aff></affiliation></author><author><name sortKey="Grimandi, Gael" sort="Grimandi, Gael" uniqKey="Grimandi G" first="Gaël" last="Grimandi">Gaël Grimandi</name><affiliation><nlm:aff id="A1">Matériaux d'intérêt biologique<institution>INSERM : EPI9903</institution><institution>Université de Nantes</institution><addr-line>Faculté de chirurgie dentaire
1 place Alexis Ricordeau BP84215
44042 Nantes,FR</addr-line></nlm:aff></affiliation></author></analytic><series><title level="j">Journal of Materials Science. Materials in Medicine</title><idno type="ISSN">0957-4530</idno><idno type="eISSN">1573-4838</idno><imprint><date when="2006">2006</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>The aim of the present study was to assess the efficacy of a ready-to-use injectable bone substitute on the prevention of alveolar ridge resorption after tooth extraction. Maxillary and mandibular premolars were extracted from 3 Beagle dogs with preservation of alveolar bone. Thereafter, distal sockets were filled with an injectable bone substitute (IBS), obtained by combining a polymer solution and granules of a biphasic calcium phosphate (BCP) ceramic. As a control, the mesial sockets were left unfilled. After a 3 months healing period, specimens were removed and prepared for histomorphometric evaluation with image analysis. Histomorphometric study allowed to measure the mean and the maximal heights of alveolar crest modifications. Results always showed an alveolar bone resorption in unfilled sockets. Resorption in filled maxillary sites was significantly lower than in control sites. Interestingly, an alveolar ridge augmentation was measured in mandibular filled sockets including 30 % of newly-formed bone. It was concluded that an injectable bone substitute composed of a polymeric carrier and calcium phosphate can significantly increase alveolar ridge preservation after tooth extraction.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">J Mater Sci Mater Med</journal-id><journal-title>Journal of Materials Science. Materials in Medicine</journal-title><issn pub-type="ppub">0957-4530</issn><issn pub-type="epub">1573-4838</issn><publisher><publisher-name>Kluwer Academic Publishers</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">17122930</article-id><article-id pub-id-type="pmc">2042990</article-id><article-id pub-id-type="manuscript">HALMS176538</article-id><article-id pub-id-type="doi">10.1007/s10856-006-0542-7</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject><subj-group subj-group-type="subrepository"><subject>INSERM Subrepository</subject></subj-group></subj-group></article-categories><title-group><article-title>Injectable bone substitute to preserve alveolar ridge resorption after tooth extraction: a study in dog</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Boix</surname><given-names>Damien</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Weiss</surname><given-names>Pierre</given-names></name><xref ref-type="aff" rid="A1">1</xref><xref rid="FN1" ref-type="author-notes">*</xref></contrib><contrib contrib-type="author"><name><surname>Gauthier</surname><given-names>Olivier</given-names></name><xref ref-type="aff" rid="A1">1</xref><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Guicheux</surname><given-names>Jérôme</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Bouler</surname><given-names>Jean-Michel</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Pilet</surname><given-names>Paul</given-names></name><xref ref-type="aff" rid="A3">3</xref></contrib><contrib contrib-type="author"><name><surname>Daculsi</surname><given-names>Guy</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Grimandi</surname><given-names>Gaël</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib></contrib-group><aff id="A1"><label>1</label>Matériaux d'intérêt biologique<institution>INSERM : EPI9903</institution><institution>Université de Nantes</institution><addr-line>Faculté de chirurgie dentaire
1 place Alexis Ricordeau BP84215
44042 Nantes,FR</addr-line></aff><aff id="A2"><label>2</label>Département de chirurgie<institution>Ecole Nationale Vétérinaire de Nantes</institution><addr-line>44307 Nantes,FR</addr-line></aff><aff id="A3"><label>3</label>Centre de microscopie électronique<institution>CHU Nantes</institution><institution>Université de Nantes</institution><addr-line>1 place Alexis Ricordeau
44042 Nantes,FR</addr-line></aff><author-notes><corresp id="FN1">* Correspondence should be adressed to: Pierre Weiss <email>pweiss@sante.univ-nantes.fr</email></corresp></author-notes><pub-date pub-type="ppub"><month>11</month><year>2006</year></pub-date><pub-date pub-type="epub"><day>22</day><month>11</month><year>2006</year></pub-date><pub-date pub-type="pmc-release"><day>20</day><month>11</month><year>2007</year></pub-date><volume>17</volume><issue>11</issue><fpage>1145</fpage><lpage>1152</lpage><abstract><p>The aim of the present study was to assess the efficacy of a ready-to-use injectable bone substitute on the prevention of alveolar ridge resorption after tooth extraction. Maxillary and mandibular premolars were extracted from 3 Beagle dogs with preservation of alveolar bone. Thereafter, distal sockets were filled with an injectable bone substitute (IBS), obtained by combining a polymer solution and granules of a biphasic calcium phosphate (BCP) ceramic. As a control, the mesial sockets were left unfilled. After a 3 months healing period, specimens were removed and prepared for histomorphometric evaluation with image analysis. Histomorphometric study allowed to measure the mean and the maximal heights of alveolar crest modifications. Results always showed an alveolar bone resorption in unfilled sockets. Resorption in filled maxillary sites was significantly lower than in control sites. Interestingly, an alveolar ridge augmentation was measured in mandibular filled sockets including 30 % of newly-formed bone. It was concluded that an injectable bone substitute composed of a polymeric carrier and calcium phosphate can significantly increase alveolar ridge preservation after tooth extraction.</p></abstract><kwd-group kwd-group-type="MESH"><kwd>Alveolar Process</kwd><kwd>physiology</kwd><kwd>Animals</kwd><kwd>Bone Resorption</kwd><kwd>physiopathology</kwd><kwd>prevention & control</kwd><kwd>Bone Substitutes</kwd><kwd>administration & dosage</kwd><kwd>Dogs</kwd><kwd>Injections</kwd><kwd>Tooth Extraction</kwd><kwd>Wound Healing</kwd><kwd>physiology</kwd></kwd-group><kwd-group kwd-group-type="Author"><kwd>Animal Model</kwd><kwd>Calcium Phosphates</kwd><kwd>Alveolar Ridge Resorption</kwd><kwd>In Vivo Test</kwd><kwd>Osteoconduction</kwd><kwd>Scaffold.</kwd></kwd-group></article-meta></front><floats-wrap><fig id="F1" position="float"><label>Figure 1</label><caption><p>Photographs of the ready-to-use injectable bone substitute (IBS) placed into an injector.</p></caption><graphic xlink:href="halms176538f1"></graphic></fig><fig id="F2" position="float"><label>Figure 2</label><caption><title>Photographs of the surgical procedures in Beagle dogs</title><p>a: second (P2), third (P3) and fourth (P4) left mandibular premolars (preoperative view).</p><p>b: debrided mesial and distal sockets after second, third and fourth premolar extractions.</p><p>c: IBS-filled distal sockets (DS). As control, mesial socket (MS) were left unfilled.</p><p>d: overlapping flaps sutures.</p></caption><graphic xlink:href="halms176538f2"></graphic></fig><fig id="F3" position="float"><label>Figure 3</label><caption><p>Scanning electron microscopy observations of axial sections of mandibular sockets after three month of healing. With backscattered electrons newly formed bone appeared in dark grey, BCP ceramic in light grey and soft tissues and bone marrow in black (a, b). A tangent vector [white line] to the vestibular and lingual cortical was drawn, (bar = 0,5 mm)</p><p>a: unfilled socket. Note the presence of a collapse below the vector (*).</p><p>b: IBS-filled socket. Note the presence of mineralized tissues above the vector (white arrows). S+ indicates the alveolar ridge augmentation above the vector (white double arrows).</p></caption><graphic xlink:href="halms176538f3"></graphic></fig><fig id="F4" position="float"><label>Figure 4</label><caption><p>Mean particulate size distribution of BCP powder, BCP in IBS before sterilisation and in the final injected product. Results were obtained by laser diffraction and are expressed as percent of the total volume of particles.</p></caption><graphic xlink:href="halms176538f4"></graphic></fig><fig id="F5" position="float"><label>Figure 5</label><caption><p>Extrusion of the BCP mixture through a 4-mm hole at a rate of 0.1 mm/sec. Compression strength measurements on the piston of an injection syringe were recorded with a computer to obtain these profiles. Experiments was repeated three times (test1, 2 and 3).</p></caption><graphic xlink:href="halms176538f5"></graphic></fig><fig id="F6" position="float"><label>Figure 6</label><caption><p>Variations of mean heights (MeH) and maximal heights (MxH) that separated the vector of the alveolar crest summit after three months of socket healing either in control filled maxillary or mandibular sites. Results are expressed in mm [mean ± SEM].</p><p>*: P < 0,01 as compared to maxillary control.</p><p>#: p < 0,01 as compared to mandibular control.</p></caption><graphic xlink:href="halms176538f6"></graphic></fig></floats-wrap></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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