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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">CURRENT CONCEPTS IN MANAGEMENT OF ORAL CANCER – SURGERY</title><author><name sortKey="Shah, Jatin P" sort="Shah, Jatin P" uniqKey="Shah J" first="Jatin P." last="Shah">Jatin P. Shah</name></author><author><name sortKey="Gil, Ziv" sort="Gil, Ziv" uniqKey="Gil Z" first="Ziv" last="Gil">Ziv Gil</name></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">18674952</idno><idno type="pmc">4130348</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4130348</idno><idno type="RBID">PMC:4130348</idno><idno type="doi">10.1016/j.oraloncology.2008.05.017</idno><date when="2008">2008</date><idno type="wicri:Area/Pmc/Corpus">002793</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002793</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">CURRENT CONCEPTS IN MANAGEMENT OF ORAL CANCER – SURGERY</title><author><name sortKey="Shah, Jatin P" sort="Shah, Jatin P" uniqKey="Shah J" first="Jatin P." last="Shah">Jatin P. Shah</name></author><author><name sortKey="Gil, Ziv" sort="Gil, Ziv" uniqKey="Gil Z" first="Ziv" last="Gil">Ziv Gil</name></author></analytic><series><title level="j">Oral oncology</title><idno type="ISSN">1368-8375</idno><idno type="eISSN">1879-0593</idno><imprint><date when="2008">2008</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P1">Oral cancer is the sixth most common cancer worldwide, with a high prevalence in South Asia. Tobacco and alcohol consumption remain the most dominant etiologic factors, however HPV has been recently implicated in oral cancer. Surgery is the most well established mode of initial definitive treatment for a majority of oral cancers. The factors that affect choice of treatment are related to the tumor and the patient. Primary site, location, size, proximity to bone, and depth of infiltration are factors which influence a particular surgical approach. Tumors that approach or involve the mandible require specific understanding of the mechanism of bone involvement. This facilitates the employment of mandible sparing approaches such as marginal mandibulectomy and mandibulotomy. Reconstruction of major surgical defects in the oral cavity requires use of a free flap. The radial forearm free flap provides excellent soft tissue and lining for soft tissue defects in the oral cavity. The fibula free flap remains the choice for mandibular reconstruction.</p><p id="P2">Over the course of the past thirty years there has been improvement in the overall survival of patients with oral carcinoma largely due to the improved understanding of the biology of local progression, early identification and treatment of metastatic lymph nodes in the neck, and employment of adjuvant postoperative radiotherapy and chemoradiotherapy.</p><p id="P3">The role of surgery in primary squamous cell carcinomas in other sites in the head and neck has evolved with integration of multidisciplinary treatment approaches employing chemotherapy and radiotherapy either sequentially or concurrently. Thus, larynx preservation with concurrent chemoradiotherapy has become the standard of care for locally advanced carcinomas of the larynx or pharynx requiring total laryngectomy. On the other hand, for early staged tumors of the larynx and pharynx, transoral laser microsurgery has become an effective means of local control of these lesions. Advances in skull base surgery have significantly improved the survivorship of patients with malignant tumors of the paranasal sinuses approaching or involving the skull base. Surgery thus remains the mainstay of management of a majority of neoplasms arising in the head and neck area. Similarly, the role of the surgeon is essential throughout the life history of a patient with a malignant neoplasm in the head and neck area, from initial diagnosis through definitive treatment, post-treatment surveillance, management of complications, rehabilitation of the sequelae of treatment, and finally for palliation of symptoms.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">9709118</journal-id><journal-id journal-id-type="pubmed-jr-id">20631</journal-id><journal-id journal-id-type="nlm-ta">Oral Oncol</journal-id><journal-id journal-id-type="iso-abbrev">Oral Oncol.</journal-id><journal-title-group><journal-title>Oral oncology</journal-title></journal-title-group><issn pub-type="ppub">1368-8375</issn><issn pub-type="epub">1879-0593</issn></journal-meta><article-meta><article-id pub-id-type="pmid">18674952</article-id><article-id pub-id-type="pmc">4130348</article-id><article-id pub-id-type="doi">10.1016/j.oraloncology.2008.05.017</article-id><article-id pub-id-type="manuscript">NIHMS508973</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>CURRENT CONCEPTS IN MANAGEMENT OF ORAL CANCER – SURGERY</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Shah</surname><given-names>Jatin P.</given-names></name><degrees>MD, PhD (Hon.), FACS, FRCS (Hon.), FRACS (Hon.), FDSRCS (Hon.)</degrees></contrib><contrib contrib-type="author"><name><surname>Gil</surname><given-names>Ziv</given-names></name><degrees>MD, PhD</degrees></contrib><aff id="A1">Head and Neck Service, Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, NY, USA</aff></contrib-group><author-notes><corresp id="cor1">Address for Correspondence: Jatin P. Shah, MD, Head and Neck Service, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, Tel: (212) 639-7233, Fax: (212) 717-3302, <email>shahj@mskcc.org</email></corresp></author-notes><pub-date pub-type="nihms-submitted"><day>3</day><month>7</month><year>2014</year></pub-date><pub-date pub-type="epub"><day>31</day><month>7</month><year>2008</year></pub-date><pub-date pub-type="ppub"><season>Apr-May</season><year>2009</year></pub-date><pub-date pub-type="pmc-release"><day>12</day><month>8</month><year>2014</year></pub-date><volume>45</volume><issue>0</issue><fpage>394</fpage><lpage>401</lpage><pmc-comment>elocation-id from pubmed: 10.1016/j.oraloncology.2008.05.017</pmc-comment>
<permissions><copyright-statement>© 2008 Elsevier Ltd. All rights reserved.</copyright-statement><copyright-year>2008</copyright-year></permissions><abstract><p id="P1">Oral cancer is the sixth most common cancer worldwide, with a high prevalence in South Asia. Tobacco and alcohol consumption remain the most dominant etiologic factors, however HPV has been recently implicated in oral cancer. Surgery is the most well established mode of initial definitive treatment for a majority of oral cancers. The factors that affect choice of treatment are related to the tumor and the patient. Primary site, location, size, proximity to bone, and depth of infiltration are factors which influence a particular surgical approach. Tumors that approach or involve the mandible require specific understanding of the mechanism of bone involvement. This facilitates the employment of mandible sparing approaches such as marginal mandibulectomy and mandibulotomy. Reconstruction of major surgical defects in the oral cavity requires use of a free flap. The radial forearm free flap provides excellent soft tissue and lining for soft tissue defects in the oral cavity. The fibula free flap remains the choice for mandibular reconstruction.</p><p id="P2">Over the course of the past thirty years there has been improvement in the overall survival of patients with oral carcinoma largely due to the improved understanding of the biology of local progression, early identification and treatment of metastatic lymph nodes in the neck, and employment of adjuvant postoperative radiotherapy and chemoradiotherapy.</p><p id="P3">The role of surgery in primary squamous cell carcinomas in other sites in the head and neck has evolved with integration of multidisciplinary treatment approaches employing chemotherapy and radiotherapy either sequentially or concurrently. Thus, larynx preservation with concurrent chemoradiotherapy has become the standard of care for locally advanced carcinomas of the larynx or pharynx requiring total laryngectomy. On the other hand, for early staged tumors of the larynx and pharynx, transoral laser microsurgery has become an effective means of local control of these lesions. Advances in skull base surgery have significantly improved the survivorship of patients with malignant tumors of the paranasal sinuses approaching or involving the skull base. Surgery thus remains the mainstay of management of a majority of neoplasms arising in the head and neck area. Similarly, the role of the surgeon is essential throughout the life history of a patient with a malignant neoplasm in the head and neck area, from initial diagnosis through definitive treatment, post-treatment surveillance, management of complications, rehabilitation of the sequelae of treatment, and finally for palliation of symptoms.</p></abstract><kwd-group><kwd>Oral Cancer</kwd><kwd>Oral Cancer Surgery</kwd><kwd>Head and Neck Cancer</kwd><kwd>Head and Neck Cancer Surgery</kwd><kwd>Oral Cancer Outcomes</kwd><kwd>Multi-Modality Treatment</kwd><kwd>Advanced Mouth Cancer</kwd><kwd>Mouth Cancer Treatment</kwd><kwd>Multidisciplinary Treatment Oral Cancer</kwd></kwd-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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