Injectable Bone Tissue Engineering Using Expanded Mesenchymal Stem Cells
Identifieur interne : 002776 ( Pmc/Corpus ); précédent : 002775; suivant : 002777Injectable Bone Tissue Engineering Using Expanded Mesenchymal Stem Cells
Auteurs : Yoichi Yamada ; Sayaka Nakamura ; Kenji Ito ; Eri Umemura ; Kenji Hara ; Tetsuro Nagasaka ; Akihiro Abe ; Shunsuke Baba ; Yasushi Furuichi ; Yuichi Izumi ; Ophir D. Klein ; Toshihiko WakabayashiSource :
- Stem cells (Dayton, Ohio) [ 1066-5099 ] ; 2013.
Abstract
Patients suffering from bone defects are often treated with autologous bone transplants, but this therapy can cause many complications. New approaches are therefore needed to improve treatment for bone defects, and stem cell therapy presents an exciting alternative approach. Although extensive evidence from basic studies using stem cells has been reported, very few clinical applications using stem cells for bone tissue engineering have been developed. We investigated whether injectable tissue-engineered bone composed of mesenchymal stem cells (MSCs) and platelet rich plasma was able to regenerate functional bone in alveolar deficiencies. We performed these studies in animals and subsequently carried out pilot trial cases in patients with long-term follow up; these showed good bone formation using minimally invasive MSC transplantation. All patients exhibited significantly improved bone volume with no side effects. Newly formed bone areas at 3 months was significantly higher than the pre-operation baseline (
Url:
DOI: 10.1002/stem.1300
PubMed: 23225744
PubMed Central: 4043220
Links to Exploration step
PMC:4043220Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Injectable Bone Tissue Engineering Using Expanded Mesenchymal Stem Cells</title>
<author><name sortKey="Yamada, Yoichi" sort="Yamada, Yoichi" uniqKey="Yamada Y" first="Yoichi" last="Yamada">Yoichi Yamada</name>
<affiliation><nlm:aff id="A1">Center for Genetic and Regenerative Medicine, Nagoya University School of Medicine, 65 Tsuruma-cho, Showa-ku, Nagoya 466-8550, Japan.</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="A2">Departments of Orofacial Sciences and Pediatrics and Program in Craniofacial and Mesenchymal Biology, University of California, San Francisco, CA 94143, USA.</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="A3">Department of Oral and Maxillofacial Surgery, Aichi Medical University School of Medicine, Yazako, Nagakute, Aichi, 480-1195, Japan.</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Nakamura, Sayaka" sort="Nakamura, Sayaka" uniqKey="Nakamura S" first="Sayaka" last="Nakamura">Sayaka Nakamura</name>
<affiliation><nlm:aff id="A2">Departments of Orofacial Sciences and Pediatrics and Program in Craniofacial and Mesenchymal Biology, University of California, San Francisco, CA 94143, USA.</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="A4">Department of Oral and Maxillofacial Surgery, Nagoya University Graduate School of Medicine, 65 Tsuruma-cho, Showa-ku, Nagoya 466-8550, Japan.</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Ito, Kenji" sort="Ito, Kenji" uniqKey="Ito K" first="Kenji" last="Ito">Kenji Ito</name>
<affiliation><nlm:aff id="A4">Department of Oral and Maxillofacial Surgery, Nagoya University Graduate School of Medicine, 65 Tsuruma-cho, Showa-ku, Nagoya 466-8550, Japan.</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Umemura, Eri" sort="Umemura, Eri" uniqKey="Umemura E" first="Eri" last="Umemura">Eri Umemura</name>
<affiliation><nlm:aff id="A4">Department of Oral and Maxillofacial Surgery, Nagoya University Graduate School of Medicine, 65 Tsuruma-cho, Showa-ku, Nagoya 466-8550, Japan.</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Hara, Kenji" sort="Hara, Kenji" uniqKey="Hara K" first="Kenji" last="Hara">Kenji Hara</name>
<affiliation><nlm:aff id="A4">Department of Oral and Maxillofacial Surgery, Nagoya University Graduate School of Medicine, 65 Tsuruma-cho, Showa-ku, Nagoya 466-8550, Japan.</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Nagasaka, Tetsuro" sort="Nagasaka, Tetsuro" uniqKey="Nagasaka T" first="Tetsuro" last="Nagasaka">Tetsuro Nagasaka</name>
<affiliation><nlm:aff id="A5">Department of Medical Technology, School of Health Science, Nagoya University, 1-1-20 Daikominami, Higashi-ku, Nagoya, 461-8673, Japan</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Abe, Akihiro" sort="Abe, Akihiro" uniqKey="Abe A" first="Akihiro" last="Abe">Akihiro Abe</name>
<affiliation><nlm:aff id="A6">Department of Hematology, Fujita Health University, 1–98. Dengakugakubo, Kutsukake-cho,Toyoake, Aichi 470–1192, Japan.</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Baba, Shunsuke" sort="Baba, Shunsuke" uniqKey="Baba S" first="Shunsuke" last="Baba">Shunsuke Baba</name>
<affiliation><nlm:aff id="A7">Department of Oral Implantology, Osaka Dental University, 8-1 Kuzuhahanazono-cho Hirakata, Osaka 573-1121, Japan.</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Furuichi, Yasushi" sort="Furuichi, Yasushi" uniqKey="Furuichi Y" first="Yasushi" last="Furuichi">Yasushi Furuichi</name>
<affiliation><nlm:aff id="A8">Division of Periodontology & Endodontology, Department of Oral Rehabilitation, School of Dentistry, Health Sciences University of Hokkaido, 1757 Kanazawa, Ishikari-Tobetsu, Hokkaido, 061-0293, Japan</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Izumi, Yuichi" sort="Izumi, Yuichi" uniqKey="Izumi Y" first="Yuichi" last="Izumi">Yuichi Izumi</name>
<affiliation><nlm:aff id="A9">Department of Periodontology, Graduate school of Medical and Dental Sciences Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8510, Japan.</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Klein, Ophir D" sort="Klein, Ophir D" uniqKey="Klein O" first="Ophir D." last="Klein">Ophir D. Klein</name>
<affiliation><nlm:aff id="A2">Departments of Orofacial Sciences and Pediatrics and Program in Craniofacial and Mesenchymal Biology, University of California, San Francisco, CA 94143, USA.</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Wakabayashi, Toshihiko" sort="Wakabayashi, Toshihiko" uniqKey="Wakabayashi T" first="Toshihiko" last="Wakabayashi">Toshihiko Wakabayashi</name>
<affiliation><nlm:aff id="A1">Center for Genetic and Regenerative Medicine, Nagoya University School of Medicine, 65 Tsuruma-cho, Showa-ku, Nagoya 466-8550, Japan.</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="A10">Department of Neurosurgery, Nagoya University Graduate School of Medicine, 65 Tsuruma-cho, Showa-ku, Nagoya 466-8550, Japan.</nlm:aff>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">23225744</idno>
<idno type="pmc">4043220</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4043220</idno>
<idno type="RBID">PMC:4043220</idno>
<idno type="doi">10.1002/stem.1300</idno>
<date when="2013">2013</date>
<idno type="wicri:Area/Pmc/Corpus">002776</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002776</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Injectable Bone Tissue Engineering Using Expanded Mesenchymal Stem Cells</title>
<author><name sortKey="Yamada, Yoichi" sort="Yamada, Yoichi" uniqKey="Yamada Y" first="Yoichi" last="Yamada">Yoichi Yamada</name>
<affiliation><nlm:aff id="A1">Center for Genetic and Regenerative Medicine, Nagoya University School of Medicine, 65 Tsuruma-cho, Showa-ku, Nagoya 466-8550, Japan.</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="A2">Departments of Orofacial Sciences and Pediatrics and Program in Craniofacial and Mesenchymal Biology, University of California, San Francisco, CA 94143, USA.</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="A3">Department of Oral and Maxillofacial Surgery, Aichi Medical University School of Medicine, Yazako, Nagakute, Aichi, 480-1195, Japan.</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Nakamura, Sayaka" sort="Nakamura, Sayaka" uniqKey="Nakamura S" first="Sayaka" last="Nakamura">Sayaka Nakamura</name>
<affiliation><nlm:aff id="A2">Departments of Orofacial Sciences and Pediatrics and Program in Craniofacial and Mesenchymal Biology, University of California, San Francisco, CA 94143, USA.</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="A4">Department of Oral and Maxillofacial Surgery, Nagoya University Graduate School of Medicine, 65 Tsuruma-cho, Showa-ku, Nagoya 466-8550, Japan.</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Ito, Kenji" sort="Ito, Kenji" uniqKey="Ito K" first="Kenji" last="Ito">Kenji Ito</name>
<affiliation><nlm:aff id="A4">Department of Oral and Maxillofacial Surgery, Nagoya University Graduate School of Medicine, 65 Tsuruma-cho, Showa-ku, Nagoya 466-8550, Japan.</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Umemura, Eri" sort="Umemura, Eri" uniqKey="Umemura E" first="Eri" last="Umemura">Eri Umemura</name>
<affiliation><nlm:aff id="A4">Department of Oral and Maxillofacial Surgery, Nagoya University Graduate School of Medicine, 65 Tsuruma-cho, Showa-ku, Nagoya 466-8550, Japan.</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Hara, Kenji" sort="Hara, Kenji" uniqKey="Hara K" first="Kenji" last="Hara">Kenji Hara</name>
<affiliation><nlm:aff id="A4">Department of Oral and Maxillofacial Surgery, Nagoya University Graduate School of Medicine, 65 Tsuruma-cho, Showa-ku, Nagoya 466-8550, Japan.</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Nagasaka, Tetsuro" sort="Nagasaka, Tetsuro" uniqKey="Nagasaka T" first="Tetsuro" last="Nagasaka">Tetsuro Nagasaka</name>
<affiliation><nlm:aff id="A5">Department of Medical Technology, School of Health Science, Nagoya University, 1-1-20 Daikominami, Higashi-ku, Nagoya, 461-8673, Japan</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Abe, Akihiro" sort="Abe, Akihiro" uniqKey="Abe A" first="Akihiro" last="Abe">Akihiro Abe</name>
<affiliation><nlm:aff id="A6">Department of Hematology, Fujita Health University, 1–98. Dengakugakubo, Kutsukake-cho,Toyoake, Aichi 470–1192, Japan.</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Baba, Shunsuke" sort="Baba, Shunsuke" uniqKey="Baba S" first="Shunsuke" last="Baba">Shunsuke Baba</name>
<affiliation><nlm:aff id="A7">Department of Oral Implantology, Osaka Dental University, 8-1 Kuzuhahanazono-cho Hirakata, Osaka 573-1121, Japan.</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Furuichi, Yasushi" sort="Furuichi, Yasushi" uniqKey="Furuichi Y" first="Yasushi" last="Furuichi">Yasushi Furuichi</name>
<affiliation><nlm:aff id="A8">Division of Periodontology & Endodontology, Department of Oral Rehabilitation, School of Dentistry, Health Sciences University of Hokkaido, 1757 Kanazawa, Ishikari-Tobetsu, Hokkaido, 061-0293, Japan</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Izumi, Yuichi" sort="Izumi, Yuichi" uniqKey="Izumi Y" first="Yuichi" last="Izumi">Yuichi Izumi</name>
<affiliation><nlm:aff id="A9">Department of Periodontology, Graduate school of Medical and Dental Sciences Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8510, Japan.</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Klein, Ophir D" sort="Klein, Ophir D" uniqKey="Klein O" first="Ophir D." last="Klein">Ophir D. Klein</name>
<affiliation><nlm:aff id="A2">Departments of Orofacial Sciences and Pediatrics and Program in Craniofacial and Mesenchymal Biology, University of California, San Francisco, CA 94143, USA.</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Wakabayashi, Toshihiko" sort="Wakabayashi, Toshihiko" uniqKey="Wakabayashi T" first="Toshihiko" last="Wakabayashi">Toshihiko Wakabayashi</name>
<affiliation><nlm:aff id="A1">Center for Genetic and Regenerative Medicine, Nagoya University School of Medicine, 65 Tsuruma-cho, Showa-ku, Nagoya 466-8550, Japan.</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="A10">Department of Neurosurgery, Nagoya University Graduate School of Medicine, 65 Tsuruma-cho, Showa-ku, Nagoya 466-8550, Japan.</nlm:aff>
</affiliation>
</author>
</analytic>
<series><title level="j">Stem cells (Dayton, Ohio)</title>
<idno type="ISSN">1066-5099</idno>
<idno type="eISSN">1549-4918</idno>
<imprint><date when="2013">2013</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p id="P1">Patients suffering from bone defects are often treated with autologous bone transplants, but this therapy can cause many complications. New approaches are therefore needed to improve treatment for bone defects, and stem cell therapy presents an exciting alternative approach. Although extensive evidence from basic studies using stem cells has been reported, very few clinical applications using stem cells for bone tissue engineering have been developed. We investigated whether injectable tissue-engineered bone composed of mesenchymal stem cells (MSCs) and platelet rich plasma was able to regenerate functional bone in alveolar deficiencies. We performed these studies in animals and subsequently carried out pilot trial cases in patients with long-term follow up; these showed good bone formation using minimally invasive MSC transplantation. All patients exhibited significantly improved bone volume with no side effects. Newly formed bone areas at 3 months was significantly higher than the pre-operation baseline (<italic>P</italic>
<0.001) and reached levels equivalent to that of native bone. No significant bone resorption occurred during long term follow-up. Injectable tissue-engineered bone restored masticatory function in patients. This novel clinical approach represents an effective therapeutic utilization of bone tissue engineering.</p>
</div>
</front>
</TEI>
<pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">9304532</journal-id>
<journal-id journal-id-type="pubmed-jr-id">2286</journal-id>
<journal-id journal-id-type="nlm-ta">Stem Cells</journal-id>
<journal-id journal-id-type="iso-abbrev">Stem Cells</journal-id>
<journal-title-group><journal-title>Stem cells (Dayton, Ohio)</journal-title>
</journal-title-group>
<issn pub-type="ppub">1066-5099</issn>
<issn pub-type="epub">1549-4918</issn>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">23225744</article-id>
<article-id pub-id-type="pmc">4043220</article-id>
<article-id pub-id-type="doi">10.1002/stem.1300</article-id>
<article-id pub-id-type="manuscript">NIHMS575564</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Article</subject>
</subj-group>
</article-categories>
<title-group><article-title>Injectable Bone Tissue Engineering Using Expanded Mesenchymal Stem Cells</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Yamada</surname>
<given-names>Yoichi</given-names>
</name>
<xref ref-type="aff" rid="A1">a</xref>
<xref ref-type="aff" rid="A2">b</xref>
<xref ref-type="aff" rid="A3">c</xref>
<xref ref-type="corresp" rid="CR1">*</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Nakamura</surname>
<given-names>Sayaka</given-names>
</name>
<xref ref-type="aff" rid="A2">b</xref>
<xref ref-type="aff" rid="A4">d</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Ito</surname>
<given-names>Kenji</given-names>
</name>
<xref ref-type="aff" rid="A4">d</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Umemura</surname>
<given-names>Eri</given-names>
</name>
<xref ref-type="aff" rid="A4">d</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Hara</surname>
<given-names>Kenji</given-names>
</name>
<xref ref-type="aff" rid="A4">d</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Nagasaka</surname>
<given-names>Tetsuro</given-names>
</name>
<xref ref-type="aff" rid="A5">e</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Abe</surname>
<given-names>Akihiro</given-names>
</name>
<xref ref-type="aff" rid="A6">f</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Baba</surname>
<given-names>Shunsuke</given-names>
</name>
<xref ref-type="aff" rid="A7">g</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Furuichi</surname>
<given-names>Yasushi</given-names>
</name>
<xref ref-type="aff" rid="A8">h</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Izumi</surname>
<given-names>Yuichi</given-names>
</name>
<xref ref-type="aff" rid="A9">i</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Klein</surname>
<given-names>Ophir D.</given-names>
</name>
<xref ref-type="aff" rid="A2">b</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Wakabayashi</surname>
<given-names>Toshihiko</given-names>
</name>
<xref ref-type="aff" rid="A1">a</xref>
<xref ref-type="aff" rid="A10">j</xref>
</contrib>
</contrib-group>
<aff id="A1"><label>a</label>
Center for Genetic and Regenerative Medicine, Nagoya University School of Medicine, 65 Tsuruma-cho, Showa-ku, Nagoya 466-8550, Japan.</aff>
<aff id="A2"><label>b</label>
Departments of Orofacial Sciences and Pediatrics and Program in Craniofacial and Mesenchymal Biology, University of California, San Francisco, CA 94143, USA.</aff>
<aff id="A3"><label>c</label>
Department of Oral and Maxillofacial Surgery, Aichi Medical University School of Medicine, Yazako, Nagakute, Aichi, 480-1195, Japan.</aff>
<aff id="A4"><label>d</label>
Department of Oral and Maxillofacial Surgery, Nagoya University Graduate School of Medicine, 65 Tsuruma-cho, Showa-ku, Nagoya 466-8550, Japan.</aff>
<aff id="A5"><label>e</label>
Department of Medical Technology, School of Health Science, Nagoya University, 1-1-20 Daikominami, Higashi-ku, Nagoya, 461-8673, Japan</aff>
<aff id="A6"><label>f</label>
Department of Hematology, Fujita Health University, 1–98. Dengakugakubo, Kutsukake-cho,Toyoake, Aichi 470–1192, Japan.</aff>
<aff id="A7"><label>g</label>
Department of Oral Implantology, Osaka Dental University, 8-1 Kuzuhahanazono-cho Hirakata, Osaka 573-1121, Japan.</aff>
<aff id="A8"><label>h</label>
Division of Periodontology & Endodontology, Department of Oral Rehabilitation, School of Dentistry, Health Sciences University of Hokkaido, 1757 Kanazawa, Ishikari-Tobetsu, Hokkaido, 061-0293, Japan</aff>
<aff id="A9"><label>i</label>
Department of Periodontology, Graduate school of Medical and Dental Sciences Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8510, Japan.</aff>
<aff id="A10"><label>j</label>
Department of Neurosurgery, Nagoya University Graduate School of Medicine, 65 Tsuruma-cho, Showa-ku, Nagoya 466-8550, Japan.</aff>
<author-notes><corresp id="CR1"><label>*</label>
Address correspondence: Dr. Yoichi Yamada, Aichi Medical University School of Medicine, Yazako, Nagakute, Aichi, 480-1195, Japan Phone: +81-561-62-3311 (ext 2243), Fax: +81-561-61-1947 <email>yyamada@aichi-med-u.ac.jp</email>
or <email>yyamada0925@gmail.com</email>
</corresp>
</author-notes>
<pub-date pub-type="nihms-submitted"><day>24</day>
<month>4</month>
<year>2014</year>
</pub-date>
<pub-date pub-type="ppub"><month>3</month>
<year>2013</year>
</pub-date>
<pub-date pub-type="pmc-release"><day>03</day>
<month>6</month>
<year>2014</year>
</pub-date>
<volume>31</volume>
<issue>3</issue>
<fpage>572</fpage>
<lpage>580</lpage>
<pmc-comment>elocation-id from pubmed: 10.1002/stem.1300</pmc-comment>
<abstract><p id="P1">Patients suffering from bone defects are often treated with autologous bone transplants, but this therapy can cause many complications. New approaches are therefore needed to improve treatment for bone defects, and stem cell therapy presents an exciting alternative approach. Although extensive evidence from basic studies using stem cells has been reported, very few clinical applications using stem cells for bone tissue engineering have been developed. We investigated whether injectable tissue-engineered bone composed of mesenchymal stem cells (MSCs) and platelet rich plasma was able to regenerate functional bone in alveolar deficiencies. We performed these studies in animals and subsequently carried out pilot trial cases in patients with long-term follow up; these showed good bone formation using minimally invasive MSC transplantation. All patients exhibited significantly improved bone volume with no side effects. Newly formed bone areas at 3 months was significantly higher than the pre-operation baseline (<italic>P</italic>
<0.001) and reached levels equivalent to that of native bone. No significant bone resorption occurred during long term follow-up. Injectable tissue-engineered bone restored masticatory function in patients. This novel clinical approach represents an effective therapeutic utilization of bone tissue engineering.</p>
</abstract>
<kwd-group><kwd>tissue engineering</kwd>
<kwd>regenerative medicine</kwd>
<kwd>bone</kwd>
<kwd>cell transplantation</kwd>
<kwd>clinical application</kwd>
</kwd-group>
</article-meta>
</front>
</pmc>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Santé/explor/EdenteV2/Data/Pmc/Corpus
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 002776 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Pmc/Corpus/biblio.hfd -nk 002776 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Santé |area= EdenteV2 |flux= Pmc |étape= Corpus |type= RBID |clé= PMC:4043220 |texte= Injectable Bone Tissue Engineering Using Expanded Mesenchymal Stem Cells }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Pmc/Corpus/RBID.i -Sk "pubmed:23225744" \ | HfdSelect -Kh $EXPLOR_AREA/Data/Pmc/Corpus/biblio.hfd \ | NlmPubMed2Wicri -a EdenteV2
![]() | This area was generated with Dilib version V0.6.32. | ![]() |