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<fileDesc>
<titleStmt>
<title xml:lang="en">Association of serum electrolytes and smoking with salivary gland stone formation</title>
<author>
<name sortKey="Yiu, A J" sort="Yiu, A J" uniqKey="Yiu A" first="A. J." last="Yiu">A. J. Yiu</name>
<affiliation>
<nlm:aff id="A1">Calcium Signaling Laboratory, Research Service, Department of Veterans Affairs Medical Center, Washington, DC, USA</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Kalejaiye, A" sort="Kalejaiye, A" uniqKey="Kalejaiye A" first="A." last="Kalejaiye">A. Kalejaiye</name>
<affiliation>
<nlm:aff id="A1">Calcium Signaling Laboratory, Research Service, Department of Veterans Affairs Medical Center, Washington, DC, USA</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="A2">ENT Head and Neck Section, Surgical Service, Department of Veterans Affairs Medical Center, Washington, DC, USA</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Amdur, R L" sort="Amdur, R L" uniqKey="Amdur R" first="R. L." last="Amdur">R. L. Amdur</name>
<affiliation>
<nlm:aff id="A3">Biostatistics Core, Department of Veterans Affairs Medical Center, Washington, DC, USA</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Hesham, H N Todd" sort="Hesham, H N Todd" uniqKey="Hesham H" first="H. N. Todd" last="Hesham">H. N. Todd Hesham</name>
<affiliation>
<nlm:aff id="A2">ENT Head and Neck Section, Surgical Service, Department of Veterans Affairs Medical Center, Washington, DC, USA</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Bandyopadhyay, B C" sort="Bandyopadhyay, B C" uniqKey="Bandyopadhyay B" first="B. C." last="Bandyopadhyay">B. C. Bandyopadhyay</name>
<affiliation>
<nlm:aff id="A1">Calcium Signaling Laboratory, Research Service, Department of Veterans Affairs Medical Center, Washington, DC, USA</nlm:aff>
</affiliation>
</author>
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<idno type="pmid">26969301</idno>
<idno type="pmc">4862889</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4862889</idno>
<idno type="RBID">PMC:4862889</idno>
<idno type="doi">10.1016/j.ijom.2016.02.007</idno>
<date when="2016">2016</date>
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<title xml:lang="en" level="a" type="main">Association of serum electrolytes and smoking with salivary gland stone formation</title>
<author>
<name sortKey="Yiu, A J" sort="Yiu, A J" uniqKey="Yiu A" first="A. J." last="Yiu">A. J. Yiu</name>
<affiliation>
<nlm:aff id="A1">Calcium Signaling Laboratory, Research Service, Department of Veterans Affairs Medical Center, Washington, DC, USA</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Kalejaiye, A" sort="Kalejaiye, A" uniqKey="Kalejaiye A" first="A." last="Kalejaiye">A. Kalejaiye</name>
<affiliation>
<nlm:aff id="A1">Calcium Signaling Laboratory, Research Service, Department of Veterans Affairs Medical Center, Washington, DC, USA</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="A2">ENT Head and Neck Section, Surgical Service, Department of Veterans Affairs Medical Center, Washington, DC, USA</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Amdur, R L" sort="Amdur, R L" uniqKey="Amdur R" first="R. L." last="Amdur">R. L. Amdur</name>
<affiliation>
<nlm:aff id="A3">Biostatistics Core, Department of Veterans Affairs Medical Center, Washington, DC, USA</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Hesham, H N Todd" sort="Hesham, H N Todd" uniqKey="Hesham H" first="H. N. Todd" last="Hesham">H. N. Todd Hesham</name>
<affiliation>
<nlm:aff id="A2">ENT Head and Neck Section, Surgical Service, Department of Veterans Affairs Medical Center, Washington, DC, USA</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Bandyopadhyay, B C" sort="Bandyopadhyay, B C" uniqKey="Bandyopadhyay B" first="B. C." last="Bandyopadhyay">B. C. Bandyopadhyay</name>
<affiliation>
<nlm:aff id="A1">Calcium Signaling Laboratory, Research Service, Department of Veterans Affairs Medical Center, Washington, DC, USA</nlm:aff>
</affiliation>
</author>
</analytic>
<series>
<title level="j">International journal of oral and maxillofacial surgery</title>
<idno type="ISSN">0901-5027</idno>
<idno type="eISSN">1399-0020</idno>
<imprint>
<date when="2016">2016</date>
</imprint>
</series>
</biblStruct>
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<front>
<div type="abstract" xml:lang="en">
<p id="P1">To further define potential factors that may contribute to stone formation in salivary glands (sialolithiasis), a retrospective chart review was performed of patients diagnosed with sialolithiasis between March 1, 1998 and February 29, 2012. Information on salivary gland stone number, location, and size, medical history, medications, and serum electrolyte levels were collected. Associations between electrolyte levels and stone characteristics (such as stone number and size) were examined. Fifty-nine patients were identified; their median age was 58 years (range 25–89 years) and most were male (95%). Salivary stones were most commonly located in the submandibular glands (83%). Thirty-five patients (59%) had a smoking history, with 16 (27%) reported as current smokers. There was a significant association between current smoker status and stone size (mean largest stone size 12.4 ± 8.8 mm vs. 7.5 ± 4.8 mm in current smokers vs. non-smokers;
<italic>P</italic>
= 0.03). Serum sodium levels (
<italic>r</italic>
= 0.32,
<italic>P</italic>
= 0.014) and serum potassium levels (
<italic>r</italic>
= 0.31,
<italic>P</italic>
= 0.017) showed significant positive correlations with stone size. While the etiology of sialolithiasis remains unclear, smoking (which can contribute to reduced saliva flow) and higher serum sodium levels (which can reflect volume depletion) are associated with larger salivary stones.</p>
</div>
</front>
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<pmc article-type="research-article">
<pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front>
<journal-meta>
<journal-id journal-id-type="nlm-journal-id">8605826</journal-id>
<journal-id journal-id-type="pubmed-jr-id">4853</journal-id>
<journal-id journal-id-type="nlm-ta">Int J Oral Maxillofac Surg</journal-id>
<journal-id journal-id-type="iso-abbrev">Int J Oral Maxillofac Surg</journal-id>
<journal-title-group>
<journal-title>International journal of oral and maxillofacial surgery</journal-title>
</journal-title-group>
<issn pub-type="ppub">0901-5027</issn>
<issn pub-type="epub">1399-0020</issn>
</journal-meta>
<article-meta>
<article-id pub-id-type="pmid">26969301</article-id>
<article-id pub-id-type="pmc">4862889</article-id>
<article-id pub-id-type="doi">10.1016/j.ijom.2016.02.007</article-id>
<article-id pub-id-type="manuscript">NIHMS762587</article-id>
<article-categories>
<subj-group subj-group-type="heading">
<subject>Article</subject>
</subj-group>
</article-categories>
<title-group>
<article-title>Association of serum electrolytes and smoking with salivary gland stone formation</article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname>Yiu</surname>
<given-names>A. J.</given-names>
</name>
<xref ref-type="aff" rid="A1">1</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Kalejaiye</surname>
<given-names>A.</given-names>
</name>
<xref ref-type="aff" rid="A1">1</xref>
<xref ref-type="aff" rid="A2">2</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Amdur</surname>
<given-names>R. L.</given-names>
</name>
<xref ref-type="aff" rid="A3">3</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Hesham</surname>
<given-names>H. N. Todd</given-names>
</name>
<xref ref-type="aff" rid="A2">2</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Bandyopadhyay</surname>
<given-names>B. C.</given-names>
</name>
<xref ref-type="aff" rid="A1">1</xref>
</contrib>
</contrib-group>
<aff id="A1">
<label>1</label>
Calcium Signaling Laboratory, Research Service, Department of Veterans Affairs Medical Center, Washington, DC, USA</aff>
<aff id="A2">
<label>2</label>
ENT Head and Neck Section, Surgical Service, Department of Veterans Affairs Medical Center, Washington, DC, USA</aff>
<aff id="A3">
<label>3</label>
Biostatistics Core, Department of Veterans Affairs Medical Center, Washington, DC, USA</aff>
<author-notes>
<corresp id="cor1">Correspondence: Bidhan C. Bandyopadhyay, Calcium Signaling Laboratory, 151 Research Service, DVA Medical Center, 50 Irving Street NW, Washington, DC 20422, USA, Tel: +1 202 745 8622, Fax: +1 202 462 2006,
<email>bidhan.bandyopadhyay@va.gov</email>
</corresp>
</author-notes>
<pub-date pub-type="nihms-submitted">
<day>9</day>
<month>3</month>
<year>2016</year>
</pub-date>
<pub-date pub-type="epub">
<day>08</day>
<month>3</month>
<year>2016</year>
</pub-date>
<pub-date pub-type="ppub">
<month>6</month>
<year>2016</year>
</pub-date>
<pub-date pub-type="pmc-release">
<day>01</day>
<month>6</month>
<year>2017</year>
</pub-date>
<volume>45</volume>
<issue>6</issue>
<fpage>764</fpage>
<lpage>768</lpage>
<pmc-comment>elocation-id from pubmed: 10.1016/j.ijom.2016.02.007</pmc-comment>
<abstract>
<p id="P1">To further define potential factors that may contribute to stone formation in salivary glands (sialolithiasis), a retrospective chart review was performed of patients diagnosed with sialolithiasis between March 1, 1998 and February 29, 2012. Information on salivary gland stone number, location, and size, medical history, medications, and serum electrolyte levels were collected. Associations between electrolyte levels and stone characteristics (such as stone number and size) were examined. Fifty-nine patients were identified; their median age was 58 years (range 25–89 years) and most were male (95%). Salivary stones were most commonly located in the submandibular glands (83%). Thirty-five patients (59%) had a smoking history, with 16 (27%) reported as current smokers. There was a significant association between current smoker status and stone size (mean largest stone size 12.4 ± 8.8 mm vs. 7.5 ± 4.8 mm in current smokers vs. non-smokers;
<italic>P</italic>
= 0.03). Serum sodium levels (
<italic>r</italic>
= 0.32,
<italic>P</italic>
= 0.014) and serum potassium levels (
<italic>r</italic>
= 0.31,
<italic>P</italic>
= 0.017) showed significant positive correlations with stone size. While the etiology of sialolithiasis remains unclear, smoking (which can contribute to reduced saliva flow) and higher serum sodium levels (which can reflect volume depletion) are associated with larger salivary stones.</p>
</abstract>
<kwd-group>
<kwd>sialolithiasis</kwd>
<kwd>patient factor</kwd>
<kwd>smoking</kwd>
<kwd>diuretics</kwd>
<kwd>serum electrolyte levels</kwd>
</kwd-group>
</article-meta>
</front>
</pmc>
</record>

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