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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Regenerating mandibular bone using rhBMP-2: part 2 – treatment of chronic, defect non-union fractures</title><author><name sortKey="Verstraete, Frank J M" sort="Verstraete, Frank J M" uniqKey="Verstraete F" first="Frank J. M." last="Verstraete">Frank J. M. Verstraete</name><affiliation><nlm:aff id="A1">Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California, Davis, CA</nlm:aff></affiliation></author><author><name sortKey="Arzi, Boaz" sort="Arzi, Boaz" uniqKey="Arzi B" first="Boaz" last="Arzi">Boaz Arzi</name><affiliation><nlm:aff id="A1">Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California, Davis, CA</nlm:aff></affiliation></author><author><name sortKey="Huey, Daniel J" sort="Huey, Daniel J" uniqKey="Huey D" first="Daniel J." last="Huey">Daniel J. Huey</name><affiliation><nlm:aff id="A2">Department of Biomedical Engineering, College of Engineering, University of California, Davis, CA</nlm:aff></affiliation></author><author><name sortKey="Cissell, Derek D" sort="Cissell, Derek D" uniqKey="Cissell D" first="Derek D." last="Cissell">Derek D. Cissell</name><affiliation><nlm:aff id="A2">Department of Biomedical Engineering, College of Engineering, University of California, Davis, CA</nlm:aff></affiliation></author><author><name sortKey="Athanasiou, Kyriacos A" sort="Athanasiou, Kyriacos A" uniqKey="Athanasiou K" first="Kyriacos A." last="Athanasiou">Kyriacos A. Athanasiou</name><affiliation><nlm:aff id="A2">Department of Biomedical Engineering, College of Engineering, University of California, Davis, CA</nlm:aff></affiliation><affiliation><nlm:aff id="A3">Department of Orthopedic Surgery, School of Medicine, University of California, Davis, CA</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">24410723</idno><idno type="pmc">4451182</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4451182</idno><idno type="RBID">PMC:4451182</idno><idno type="doi">10.1111/j.1532-950X.2014.12122.x</idno><date when="2014">2014</date><idno type="wicri:Area/Pmc/Corpus">002718</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002718</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Regenerating mandibular bone using rhBMP-2: part 2 – treatment of chronic, defect non-union fractures</title><author><name sortKey="Verstraete, Frank J M" sort="Verstraete, Frank J M" uniqKey="Verstraete F" first="Frank J. M." last="Verstraete">Frank J. M. Verstraete</name><affiliation><nlm:aff id="A1">Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California, Davis, CA</nlm:aff></affiliation></author><author><name sortKey="Arzi, Boaz" sort="Arzi, Boaz" uniqKey="Arzi B" first="Boaz" last="Arzi">Boaz Arzi</name><affiliation><nlm:aff id="A1">Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California, Davis, CA</nlm:aff></affiliation></author><author><name sortKey="Huey, Daniel J" sort="Huey, Daniel J" uniqKey="Huey D" first="Daniel J." last="Huey">Daniel J. Huey</name><affiliation><nlm:aff id="A2">Department of Biomedical Engineering, College of Engineering, University of California, Davis, CA</nlm:aff></affiliation></author><author><name sortKey="Cissell, Derek D" sort="Cissell, Derek D" uniqKey="Cissell D" first="Derek D." last="Cissell">Derek D. Cissell</name><affiliation><nlm:aff id="A2">Department of Biomedical Engineering, College of Engineering, University of California, Davis, CA</nlm:aff></affiliation></author><author><name sortKey="Athanasiou, Kyriacos A" sort="Athanasiou, Kyriacos A" uniqKey="Athanasiou K" first="Kyriacos A." last="Athanasiou">Kyriacos A. Athanasiou</name><affiliation><nlm:aff id="A2">Department of Biomedical Engineering, College of Engineering, University of California, Davis, CA</nlm:aff></affiliation><affiliation><nlm:aff id="A3">Department of Orthopedic Surgery, School of Medicine, University of California, Davis, CA</nlm:aff></affiliation></author></analytic><series><title level="j">Veterinary surgery : VS</title><idno type="ISSN">0161-3499</idno><idno type="eISSN">1532-950X</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="S1"><title>Objective</title><p id="P1">To describe a surgical technique utilizing a regenerative approach and internal fixation for reconstruction of critical size bone defect non-union mandibular fractures.</p></sec><sec id="S2"><title>Study design</title><p id="P2">Case series</p></sec><sec id="S3"><title>Animals</title><p id="P3">Dogs (n = 6) that had internal fixation of defect non-union mandibular fracture.</p></sec><sec id="S4"><title>Methods</title><p id="P4">In 5 of the 6 cases the repair was staged and extraction of teeth performed during the first procedure. After 21-98 days (mean 27 days) a pharyngotomy intubation and temporary maxillomandibular fixation were performed. Using an extraoral approach, a locking titanium miniplate plate was contoured and secured. A compression resistant matrix (CRM) infused with rhBMP-2, was implanted in the defect. The implant was then covered with a soft tissue envelope followed by routine closure.</p></sec><sec id="S5"><title>Results</title><p id="P5">All dogs had healed with intact gingival covering over the mandibular fracture site defect and had immediate return to normal function and correct occlusion. Hard-tissue formation was observed clinically within 2 weeks and solid cortical bone formation within 3 months. Computed tomographic findings in one case at 3 months postoperatively demonstrated that the newly regenerated mandibular bone had 92% of the bone density and porosity compared to the contralateral side. Long-term follow-up revealed excellent outcome.</p></sec><sec id="S6"><title>Conclusion</title><p id="P6">Mandibular reconstruction using internal fixation and CRM infused with rhBMP-2 is an excellent solution for the treatment of critical size defect non-union fractures in dogs.</p></sec><sec id="S7"><title>Clinical Relevance</title><p id="P7">In dogs with a mandibular critical size defect non-union fractures, reconstruction using rhBMP-2 and a CRM should be considered as a viable surgical option.</p></sec></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">8113214</journal-id><journal-id journal-id-type="pubmed-jr-id">7991</journal-id><journal-id journal-id-type="nlm-ta">Vet Surg</journal-id><journal-id journal-id-type="iso-abbrev">Vet Surg</journal-id><journal-title-group><journal-title>Veterinary surgery : VS</journal-title></journal-title-group><issn pub-type="ppub">0161-3499</issn><issn pub-type="epub">1532-950X</issn></journal-meta><article-meta><article-id pub-id-type="pmid">24410723</article-id><article-id pub-id-type="pmc">4451182</article-id><article-id pub-id-type="doi">10.1111/j.1532-950X.2014.12122.x</article-id><article-id pub-id-type="manuscript">NIHMS691427</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Regenerating mandibular bone using rhBMP-2: part 2 – treatment of chronic, defect non-union fractures</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Verstraete</surname><given-names>Frank J.M.</given-names></name><degrees>DrMedVet, MMedVet, Diplomate AVDC, ECVS and EVDC</degrees><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Arzi</surname><given-names>Boaz</given-names></name><degrees>DVM, Diplomate AVDC</degrees><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Huey</surname><given-names>Daniel J.</given-names></name><degrees>PhD</degrees><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Cissell</surname><given-names>Derek D.</given-names></name><degrees>VMD, Diplomate ACVR</degrees><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Athanasiou</surname><given-names>Kyriacos A.</given-names></name><degrees>PhD, PE</degrees><xref ref-type="aff" rid="A2">2</xref><xref ref-type="aff" rid="A3">3</xref></contrib></contrib-group><aff id="A1"><label>1</label>Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California, Davis, CA</aff><aff id="A2"><label>2</label>Department of Biomedical Engineering, College of Engineering, University of California, Davis, CA</aff><aff id="A3"><label>3</label>Department of Orthopedic Surgery, School of Medicine, University of California, Davis, CA</aff><author-notes><corresp id="CR1">Corresponding author: Dr. Frank J.M. Verstraete, Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California, Davis, One Shield Avenue, Davis, California, 95616, USA, Tel.: (530) 752-2470, Fax: (530) 752-6042, <email>fjverstraete@ucdavis.edu</email></corresp></author-notes><pub-date pub-type="nihms-submitted"><day>20</day><month>5</month><year>2015</year></pub-date><pub-date pub-type="epub"><day>10</day><month>1</month><year>2014</year></pub-date><pub-date pub-type="ppub"><month>5</month><year>2015</year></pub-date><pub-date pub-type="pmc-release"><day>02</day><month>6</month><year>2015</year></pub-date><volume>44</volume><issue>4</issue><fpage>410</fpage><lpage>416</lpage><pmc-comment>elocation-id from pubmed: 10.1111/j.1532-950X.2014.12122.x</pmc-comment>
<abstract><sec id="S1"><title>Objective</title><p id="P1">To describe a surgical technique utilizing a regenerative approach and internal fixation for reconstruction of critical size bone defect non-union mandibular fractures.</p></sec><sec id="S2"><title>Study design</title><p id="P2">Case series</p></sec><sec id="S3"><title>Animals</title><p id="P3">Dogs (n = 6) that had internal fixation of defect non-union mandibular fracture.</p></sec><sec id="S4"><title>Methods</title><p id="P4">In 5 of the 6 cases the repair was staged and extraction of teeth performed during the first procedure. After 21-98 days (mean 27 days) a pharyngotomy intubation and temporary maxillomandibular fixation were performed. Using an extraoral approach, a locking titanium miniplate plate was contoured and secured. A compression resistant matrix (CRM) infused with rhBMP-2, was implanted in the defect. The implant was then covered with a soft tissue envelope followed by routine closure.</p></sec><sec id="S5"><title>Results</title><p id="P5">All dogs had healed with intact gingival covering over the mandibular fracture site defect and had immediate return to normal function and correct occlusion. Hard-tissue formation was observed clinically within 2 weeks and solid cortical bone formation within 3 months. Computed tomographic findings in one case at 3 months postoperatively demonstrated that the newly regenerated mandibular bone had 92% of the bone density and porosity compared to the contralateral side. Long-term follow-up revealed excellent outcome.</p></sec><sec id="S6"><title>Conclusion</title><p id="P6">Mandibular reconstruction using internal fixation and CRM infused with rhBMP-2 is an excellent solution for the treatment of critical size defect non-union fractures in dogs.</p></sec><sec id="S7"><title>Clinical Relevance</title><p id="P7">In dogs with a mandibular critical size defect non-union fractures, reconstruction using rhBMP-2 and a CRM should be considered as a viable surgical option.</p></sec></abstract></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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