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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">18F-FDG-PET/CT parameters as imaging biomarkers in oral cavity squamous cell carcinoma, is visual analysis of PET and contrast enhanced CT better than the numbers?</title><author><name sortKey="Kendi, At" sort="Kendi, At" uniqKey="Kendi A" first="At" last="Kendi">At Kendi</name><affiliation><nlm:aff id="A1">Department of Radiology and Imaging Sciences, Emory University School of Medicine, Atlanta, GA, United States</nlm:aff></affiliation></author><author><name sortKey="Corey, A" sort="Corey, A" uniqKey="Corey A" first="A" last="Corey">A. Corey</name><affiliation><nlm:aff id="A1">Department of Radiology and Imaging Sciences, Emory University School of Medicine, Atlanta, GA, United States</nlm:aff></affiliation></author><author><name sortKey="Magliocca, Kr" sort="Magliocca, Kr" uniqKey="Magliocca K" first="Kr" last="Magliocca">Kr Magliocca</name><affiliation><nlm:aff id="A2">Department of Pathology, Emory University, Atlanta, GA, United States</nlm:aff></affiliation></author><author><name sortKey="Nickleach, Dc" sort="Nickleach, Dc" uniqKey="Nickleach D" first="Dc" last="Nickleach">Dc Nickleach</name><affiliation><nlm:aff id="A3">Biostatistics & Bioinformatics Shared Resource at Winship Cancer Institute of Emory University, Atlanta, GA, United States</nlm:aff></affiliation></author><author><name sortKey="Galt, J" sort="Galt, J" uniqKey="Galt J" first="J" last="Galt">J. Galt</name><affiliation><nlm:aff id="A1">Department of Radiology and Imaging Sciences, Emory University School of Medicine, Atlanta, GA, United States</nlm:aff></affiliation></author><author><name sortKey="Switchenko, Jeffrey M" sort="Switchenko, Jeffrey M" uniqKey="Switchenko J" first="Jeffrey M." last="Switchenko">Jeffrey M. Switchenko</name><affiliation><nlm:aff id="A3">Biostatistics & Bioinformatics Shared Resource at Winship Cancer Institute of Emory University, Atlanta, GA, United States</nlm:aff></affiliation></author><author><name sortKey="El Deiry, Mw" sort="El Deiry, Mw" uniqKey="El Deiry M" first="Mw" last="El-Deiry">Mw El-Deiry</name><affiliation><nlm:aff id="A4">Otolaryngology Head and Neck Surgery, Emory University, Atlanta, GA, United States</nlm:aff></affiliation></author><author><name sortKey="Wadsworth, Jt" sort="Wadsworth, Jt" uniqKey="Wadsworth J" first="Jt" last="Wadsworth">Jt Wadsworth</name><affiliation><nlm:aff id="A4">Otolaryngology Head and Neck Surgery, Emory University, Atlanta, GA, United States</nlm:aff></affiliation></author><author><name sortKey="Hudgins, Pa" sort="Hudgins, Pa" uniqKey="Hudgins P" first="Pa" last="Hudgins">Pa Hudgins</name><affiliation><nlm:aff id="A1">Department of Radiology and Imaging Sciences, Emory University School of Medicine, Atlanta, GA, United States</nlm:aff></affiliation></author><author><name sortKey="Saba, Nf" sort="Saba, Nf" uniqKey="Saba N" first="Nf" last="Saba">Nf Saba</name><affiliation><nlm:aff id="A5">Hematology Oncology, Winship Cancer Institute of Emory University, Atlanta, GA, United States</nlm:aff></affiliation></author><author><name sortKey="Schuster, Dm" sort="Schuster, Dm" uniqKey="Schuster D" first="Dm" last="Schuster">Dm Schuster</name><affiliation><nlm:aff id="A1">Department of Radiology and Imaging Sciences, Emory University School of Medicine, Atlanta, GA, United States</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">25816993</idno><idno type="pmc">4927192</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4927192</idno><idno type="RBID">PMC:4927192</idno><idno type="doi">10.1016/j.ejrad.2015.02.030</idno><date when="2015">2015</date><idno type="wicri:Area/Pmc/Corpus">002716</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002716</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">18F-FDG-PET/CT parameters as imaging biomarkers in oral cavity squamous cell carcinoma, is visual analysis of PET and contrast enhanced CT better than the numbers?</title><author><name sortKey="Kendi, At" sort="Kendi, At" uniqKey="Kendi A" first="At" last="Kendi">At Kendi</name><affiliation><nlm:aff id="A1">Department of Radiology and Imaging Sciences, Emory University School of Medicine, Atlanta, GA, United States</nlm:aff></affiliation></author><author><name sortKey="Corey, A" sort="Corey, A" uniqKey="Corey A" first="A" last="Corey">A. Corey</name><affiliation><nlm:aff id="A1">Department of Radiology and Imaging Sciences, Emory University School of Medicine, Atlanta, GA, United States</nlm:aff></affiliation></author><author><name sortKey="Magliocca, Kr" sort="Magliocca, Kr" uniqKey="Magliocca K" first="Kr" last="Magliocca">Kr Magliocca</name><affiliation><nlm:aff id="A2">Department of Pathology, Emory University, Atlanta, GA, United States</nlm:aff></affiliation></author><author><name sortKey="Nickleach, Dc" sort="Nickleach, Dc" uniqKey="Nickleach D" first="Dc" last="Nickleach">Dc Nickleach</name><affiliation><nlm:aff id="A3">Biostatistics & Bioinformatics Shared Resource at Winship Cancer Institute of Emory University, Atlanta, GA, United States</nlm:aff></affiliation></author><author><name sortKey="Galt, J" sort="Galt, J" uniqKey="Galt J" first="J" last="Galt">J. Galt</name><affiliation><nlm:aff id="A1">Department of Radiology and Imaging Sciences, Emory University School of Medicine, Atlanta, GA, United States</nlm:aff></affiliation></author><author><name sortKey="Switchenko, Jeffrey M" sort="Switchenko, Jeffrey M" uniqKey="Switchenko J" first="Jeffrey M." last="Switchenko">Jeffrey M. Switchenko</name><affiliation><nlm:aff id="A3">Biostatistics & Bioinformatics Shared Resource at Winship Cancer Institute of Emory University, Atlanta, GA, United States</nlm:aff></affiliation></author><author><name sortKey="El Deiry, Mw" sort="El Deiry, Mw" uniqKey="El Deiry M" first="Mw" last="El-Deiry">Mw El-Deiry</name><affiliation><nlm:aff id="A4">Otolaryngology Head and Neck Surgery, Emory University, Atlanta, GA, United States</nlm:aff></affiliation></author><author><name sortKey="Wadsworth, Jt" sort="Wadsworth, Jt" uniqKey="Wadsworth J" first="Jt" last="Wadsworth">Jt Wadsworth</name><affiliation><nlm:aff id="A4">Otolaryngology Head and Neck Surgery, Emory University, Atlanta, GA, United States</nlm:aff></affiliation></author><author><name sortKey="Hudgins, Pa" sort="Hudgins, Pa" uniqKey="Hudgins P" first="Pa" last="Hudgins">Pa Hudgins</name><affiliation><nlm:aff id="A1">Department of Radiology and Imaging Sciences, Emory University School of Medicine, Atlanta, GA, United States</nlm:aff></affiliation></author><author><name sortKey="Saba, Nf" sort="Saba, Nf" uniqKey="Saba N" first="Nf" last="Saba">Nf Saba</name><affiliation><nlm:aff id="A5">Hematology Oncology, Winship Cancer Institute of Emory University, Atlanta, GA, United States</nlm:aff></affiliation></author><author><name sortKey="Schuster, Dm" sort="Schuster, Dm" uniqKey="Schuster D" first="Dm" last="Schuster">Dm Schuster</name><affiliation><nlm:aff id="A1">Department of Radiology and Imaging Sciences, Emory University School of Medicine, Atlanta, GA, United States</nlm:aff></affiliation></author></analytic><series><title level="j">European journal of radiology</title><idno type="ISSN">0720-048X</idno><idno type="eISSN">1872-7727</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="S1"><title>Purpose</title><p id="P1">This study was designed to seek associations between positron emission tomography/computed tomography (PET/CT) parameters, contrast enhanced neck computed tomography (CECT) and pathological findings, and to determine the potential prognostic value of PET/CT and CECT parameters in oral cavity squamous cell carcinoma (OCSCC).</p></sec><sec id="S2"><title>Materials and method</title><p id="P2">36 OCSCC patients underwent staging PET/CT and 30/36 of patients had CECT. PET/CT parameters were measured for the primary tumor and the hottest involved node, including maximum, mean, and peak standardized uptake values (SUV max, SUV mean, and SUV peak), metabolic tumor volume (MTV), total lesion glycolysis (TLG), standardized added metabolic activity (SAM), and normalized standardized added metabolic activity (N SAM). Qualitative assessment of PET/CT and CECT were also performed. Pathological outcomes included: perineural invasion, lymphovascular invasion, nodal extracapsular spread, grade, pathologic T and N stages. Multivariable logistic regression models were fit for each parameter and outcome adjusting for potentially confounding variables. Multivariable Cox proportional hazards models were used for progression free survival (PFS), locoregional recurrence free survival (LRFS), overall survival (OS) and distant metastasis free survival (DMFS).</p></sec><sec id="S3"><title>Results</title><p id="P3">In multivariable analysis, patients with high (>=median) tumor SUV max (OR 6.3), SUV mean (OR 6.3), MTV (OR 19.0), TLG (OR 19.0), SAM (OR 11.7) and N SAM (OR 19.0) had high pathological T-stage (T3/T4) (p<0.05). Ring/heterogeneous pattern on CECT qualitative assessment was associated with worse DMFS and OS.</p></sec><sec id="S4"><title>Conclusion</title><p id="P4">High PET/CT parameters were associated with pathologically advanced T stage (T3/T4). Qualitative assessment of CECT has prognostic value. PET/CT parameters did not predict clinical outcome.</p></sec></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">8106411</journal-id><journal-id journal-id-type="pubmed-jr-id">3584</journal-id><journal-id journal-id-type="nlm-ta">Eur J Radiol</journal-id><journal-id journal-id-type="iso-abbrev">Eur J Radiol</journal-id><journal-title-group><journal-title>European journal of radiology</journal-title></journal-title-group><issn pub-type="ppub">0720-048X</issn><issn pub-type="epub">1872-7727</issn></journal-meta><article-meta><article-id pub-id-type="pmid">25816993</article-id><article-id pub-id-type="pmc">4927192</article-id><article-id pub-id-type="doi">10.1016/j.ejrad.2015.02.030</article-id><article-id pub-id-type="manuscript">NIHMS672458</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>18F-FDG-PET/CT parameters as imaging biomarkers in oral cavity squamous cell carcinoma, is visual analysis of PET and contrast enhanced CT better than the numbers?</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Kendi</surname><given-names>AT</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Corey</surname><given-names>A</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Magliocca</surname><given-names>KR</given-names></name><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Nickleach</surname><given-names>DC</given-names></name><xref ref-type="aff" rid="A3">3</xref></contrib><contrib contrib-type="author"><name><surname>Galt</surname><given-names>J</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Switchenko</surname><given-names>Jeffrey M.</given-names></name><xref ref-type="aff" rid="A3">3</xref></contrib><contrib contrib-type="author"><name><surname>El-Deiry</surname><given-names>MW</given-names></name><xref ref-type="aff" rid="A4">4</xref></contrib><contrib contrib-type="author"><name><surname>Wadsworth</surname><given-names>JT</given-names></name><xref ref-type="aff" rid="A4">4</xref></contrib><contrib contrib-type="author"><name><surname>Hudgins</surname><given-names>PA</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Saba</surname><given-names>NF</given-names></name><xref ref-type="aff" rid="A5">5</xref></contrib><contrib contrib-type="author"><name><surname>Schuster</surname><given-names>DM</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib></contrib-group><aff id="A1"><label>1</label>Department of Radiology and Imaging Sciences, Emory University School of Medicine, Atlanta, GA, United States</aff><aff id="A2"><label>2</label>Department of Pathology, Emory University, Atlanta, GA, United States</aff><aff id="A3"><label>3</label>Biostatistics & Bioinformatics Shared Resource at Winship Cancer Institute of Emory University, Atlanta, GA, United States</aff><aff id="A4"><label>4</label>Otolaryngology Head and Neck Surgery, Emory University, Atlanta, GA, United States</aff><aff id="A5"><label>5</label>Hematology Oncology, Winship Cancer Institute of Emory University, Atlanta, GA, United States</aff><author-notes><corresp id="FN1">Corresponding author: Kendi AT. Division of Nuclear Medicine and Molecular Imaging, Department of Radiology and Imaging Sciences, 1364 Clifton Rd. NE, Atlanta Ga 30322, Phone: 404-712-4843, Fax: 404-712-7435, <email>ayse.kendi@emory.edu</email></corresp></author-notes><pub-date pub-type="nihms-submitted"><day>25</day><month>3</month><year>2015</year></pub-date><pub-date pub-type="epub"><day>14</day><month>3</month><year>2015</year></pub-date><pub-date pub-type="ppub"><month>6</month><year>2015</year></pub-date><pub-date pub-type="pmc-release"><day>29</day><month>6</month><year>2016</year></pub-date><volume>84</volume><issue>6</issue><fpage>1171</fpage><lpage>1176</lpage><pmc-comment>elocation-id from pubmed: 10.1016/j.ejrad.2015.02.030</pmc-comment>
<abstract><sec id="S1"><title>Purpose</title><p id="P1">This study was designed to seek associations between positron emission tomography/computed tomography (PET/CT) parameters, contrast enhanced neck computed tomography (CECT) and pathological findings, and to determine the potential prognostic value of PET/CT and CECT parameters in oral cavity squamous cell carcinoma (OCSCC).</p></sec><sec id="S2"><title>Materials and method</title><p id="P2">36 OCSCC patients underwent staging PET/CT and 30/36 of patients had CECT. PET/CT parameters were measured for the primary tumor and the hottest involved node, including maximum, mean, and peak standardized uptake values (SUV max, SUV mean, and SUV peak), metabolic tumor volume (MTV), total lesion glycolysis (TLG), standardized added metabolic activity (SAM), and normalized standardized added metabolic activity (N SAM). Qualitative assessment of PET/CT and CECT were also performed. Pathological outcomes included: perineural invasion, lymphovascular invasion, nodal extracapsular spread, grade, pathologic T and N stages. Multivariable logistic regression models were fit for each parameter and outcome adjusting for potentially confounding variables. Multivariable Cox proportional hazards models were used for progression free survival (PFS), locoregional recurrence free survival (LRFS), overall survival (OS) and distant metastasis free survival (DMFS).</p></sec><sec id="S3"><title>Results</title><p id="P3">In multivariable analysis, patients with high (>=median) tumor SUV max (OR 6.3), SUV mean (OR 6.3), MTV (OR 19.0), TLG (OR 19.0), SAM (OR 11.7) and N SAM (OR 19.0) had high pathological T-stage (T3/T4) (p<0.05). Ring/heterogeneous pattern on CECT qualitative assessment was associated with worse DMFS and OS.</p></sec><sec id="S4"><title>Conclusion</title><p id="P4">High PET/CT parameters were associated with pathologically advanced T stage (T3/T4). Qualitative assessment of CECT has prognostic value. PET/CT parameters did not predict clinical outcome.</p></sec></abstract></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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