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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Differential Responses of Osteoblast Lineage Cells to Nanotopographically-Modified, Microroughened Titanium-Aluminum-Vanadium Alloy Surfaces</title><author><name sortKey="Gittens, Rolando A" sort="Gittens, Rolando A" uniqKey="Gittens R" first="Rolando A." last="Gittens">Rolando A. Gittens</name><affiliation><nlm:aff id="A1">School of Materials Science and Engineering, Georgia Institute of Technology, Atlanta, Georgia, USA</nlm:aff></affiliation></author><author><name sortKey="Olivares Navarrete, Rene" sort="Olivares Navarrete, Rene" uniqKey="Olivares Navarrete R" first="Rene" last="Olivares-Navarrete">Rene Olivares-Navarrete</name><affiliation><nlm:aff id="A2">Wallace H. Coulter Department of Biomedical Engineering at Georgia Tech and Emory University, Georgia Institute of Technology, Atlanta, GA, USA</nlm:aff></affiliation></author><author><name sortKey="Mclachlan, Taylor" sort="Mclachlan, Taylor" uniqKey="Mclachlan T" first="Taylor" last="Mclachlan">Taylor Mclachlan</name><affiliation><nlm:aff id="A1">School of Materials Science and Engineering, Georgia Institute of Technology, Atlanta, Georgia, USA</nlm:aff></affiliation></author><author><name sortKey="Cai, Ye" sort="Cai, Ye" uniqKey="Cai Y" first="Ye" last="Cai">Ye Cai</name><affiliation><nlm:aff id="A1">School of Materials Science and Engineering, Georgia Institute of Technology, Atlanta, Georgia, USA</nlm:aff></affiliation></author><author><name sortKey="Hyzy, Sharon L" sort="Hyzy, Sharon L" uniqKey="Hyzy S" first="Sharon L." last="Hyzy">Sharon L. Hyzy</name><affiliation><nlm:aff id="A3">School of Biology, Georgia Institute of Technology, Atlanta, Georgia</nlm:aff></affiliation></author><author><name sortKey="Schneider, Jennifer M" sort="Schneider, Jennifer M" uniqKey="Schneider J" first="Jennifer M." last="Schneider">Jennifer M. Schneider</name><affiliation><nlm:aff id="A4">Titan Spine LLC, Mequon, Wisconsin</nlm:aff></affiliation></author><author><name sortKey="Schwartz, Zvi" sort="Schwartz, Zvi" uniqKey="Schwartz Z" first="Zvi" last="Schwartz">Zvi Schwartz</name><affiliation><nlm:aff id="A2">Wallace H. Coulter Department of Biomedical Engineering at Georgia Tech and Emory University, Georgia Institute of Technology, Atlanta, GA, USA</nlm:aff></affiliation></author><author><name sortKey="Sandhage, Kenneth H" sort="Sandhage, Kenneth H" uniqKey="Sandhage K" first="Kenneth H." last="Sandhage">Kenneth H. Sandhage</name><affiliation><nlm:aff id="A1">School of Materials Science and Engineering, Georgia Institute of Technology, Atlanta, Georgia, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A5">School of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, Georgia, USA</nlm:aff></affiliation></author><author><name sortKey="Boyan, Barbara D" sort="Boyan, Barbara D" uniqKey="Boyan B" first="Barbara D." last="Boyan">Barbara D. Boyan</name><affiliation><nlm:aff id="A1">School of Materials Science and Engineering, Georgia Institute of Technology, Atlanta, Georgia, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A2">Wallace H. Coulter Department of Biomedical Engineering at Georgia Tech and Emory University, Georgia Institute of Technology, Atlanta, GA, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A3">School of Biology, Georgia Institute of Technology, Atlanta, Georgia</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">22989383</idno><idno type="pmc">3618458</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3618458</idno><idno type="RBID">PMC:3618458</idno><idno type="doi">10.1016/j.biomaterials.2012.08.059</idno><date when="2012">2012</date><idno type="wicri:Area/Pmc/Corpus">002711</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002711</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Differential Responses of Osteoblast Lineage Cells to Nanotopographically-Modified, Microroughened Titanium-Aluminum-Vanadium Alloy Surfaces</title><author><name sortKey="Gittens, Rolando A" sort="Gittens, Rolando A" uniqKey="Gittens R" first="Rolando A." last="Gittens">Rolando A. Gittens</name><affiliation><nlm:aff id="A1">School of Materials Science and Engineering, Georgia Institute of Technology, Atlanta, Georgia, USA</nlm:aff></affiliation></author><author><name sortKey="Olivares Navarrete, Rene" sort="Olivares Navarrete, Rene" uniqKey="Olivares Navarrete R" first="Rene" last="Olivares-Navarrete">Rene Olivares-Navarrete</name><affiliation><nlm:aff id="A2">Wallace H. Coulter Department of Biomedical Engineering at Georgia Tech and Emory University, Georgia Institute of Technology, Atlanta, GA, USA</nlm:aff></affiliation></author><author><name sortKey="Mclachlan, Taylor" sort="Mclachlan, Taylor" uniqKey="Mclachlan T" first="Taylor" last="Mclachlan">Taylor Mclachlan</name><affiliation><nlm:aff id="A1">School of Materials Science and Engineering, Georgia Institute of Technology, Atlanta, Georgia, USA</nlm:aff></affiliation></author><author><name sortKey="Cai, Ye" sort="Cai, Ye" uniqKey="Cai Y" first="Ye" last="Cai">Ye Cai</name><affiliation><nlm:aff id="A1">School of Materials Science and Engineering, Georgia Institute of Technology, Atlanta, Georgia, USA</nlm:aff></affiliation></author><author><name sortKey="Hyzy, Sharon L" sort="Hyzy, Sharon L" uniqKey="Hyzy S" first="Sharon L." last="Hyzy">Sharon L. Hyzy</name><affiliation><nlm:aff id="A3">School of Biology, Georgia Institute of Technology, Atlanta, Georgia</nlm:aff></affiliation></author><author><name sortKey="Schneider, Jennifer M" sort="Schneider, Jennifer M" uniqKey="Schneider J" first="Jennifer M." last="Schneider">Jennifer M. Schneider</name><affiliation><nlm:aff id="A4">Titan Spine LLC, Mequon, Wisconsin</nlm:aff></affiliation></author><author><name sortKey="Schwartz, Zvi" sort="Schwartz, Zvi" uniqKey="Schwartz Z" first="Zvi" last="Schwartz">Zvi Schwartz</name><affiliation><nlm:aff id="A2">Wallace H. Coulter Department of Biomedical Engineering at Georgia Tech and Emory University, Georgia Institute of Technology, Atlanta, GA, USA</nlm:aff></affiliation></author><author><name sortKey="Sandhage, Kenneth H" sort="Sandhage, Kenneth H" uniqKey="Sandhage K" first="Kenneth H." last="Sandhage">Kenneth H. Sandhage</name><affiliation><nlm:aff id="A1">School of Materials Science and Engineering, Georgia Institute of Technology, Atlanta, Georgia, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A5">School of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, Georgia, USA</nlm:aff></affiliation></author><author><name sortKey="Boyan, Barbara D" sort="Boyan, Barbara D" uniqKey="Boyan B" first="Barbara D." last="Boyan">Barbara D. Boyan</name><affiliation><nlm:aff id="A1">School of Materials Science and Engineering, Georgia Institute of Technology, Atlanta, Georgia, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A2">Wallace H. Coulter Department of Biomedical Engineering at Georgia Tech and Emory University, Georgia Institute of Technology, Atlanta, GA, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A3">School of Biology, Georgia Institute of Technology, Atlanta, Georgia</nlm:aff></affiliation></author></analytic><series><title level="j">Biomaterials</title><idno type="ISSN">0142-9612</idno><idno type="eISSN">1878-5905</idno><imprint><date when="2012">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P1">Surface structural modifications at the micrometer and nanometer scales have driven improved success rates of dental and orthopaedic implants by mimicking the hierarchical structure of bone. However, how initial osteoblast-lineage cells populating an implant surface respond to different hierarchical surface topographical cues remains to be elucidated, with bone marrow mesenchymal stem cells (MSCs) or immature osteoblasts as possible initial colonizers. Here we show that in the absence of any exogenous soluble factors, osteoblastic maturation of primary human osteoblasts (HOBs) but not osteoblastic differentiation of MSCs is strongly influenced by nanostructures superimposed onto a microrough Ti6Al4V (TiAlV) alloy. The sensitivity of osteoblasts to both surface microroughness and nanostructures led to a synergistic effect on maturation and local factor production. Osteoblastic differentiation of MSCs was sensitive to TiAlV surface microroughness with respect to production of differentiation markers, but no further enhancement was found when cultured on micro/nanostructured surfaces. Superposition of nanostructures to microroughened surfaces affected final MSC numbers and enhanced production of vascular endothelial growth factor (VEGF) but the magnitude of the response was lower than for HOB cultures. Our results suggest that the differentiation state of osteoblast-lineage cells determines the recognition of surface nanostructures and subsequent cell response, which has implications for clinical evaluation of new implant surface nanomodifications.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">8100316</journal-id><journal-id journal-id-type="pubmed-jr-id">1138</journal-id><journal-id journal-id-type="nlm-ta">Biomaterials</journal-id><journal-id journal-id-type="iso-abbrev">Biomaterials</journal-id><journal-title-group><journal-title>Biomaterials</journal-title></journal-title-group><issn pub-type="ppub">0142-9612</issn><issn pub-type="epub">1878-5905</issn></journal-meta><article-meta><article-id pub-id-type="pmid">22989383</article-id><article-id pub-id-type="pmc">3618458</article-id><article-id pub-id-type="doi">10.1016/j.biomaterials.2012.08.059</article-id><article-id pub-id-type="manuscript">NIHMS408355</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Differential Responses of Osteoblast Lineage Cells to Nanotopographically-Modified, Microroughened Titanium-Aluminum-Vanadium Alloy Surfaces</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Gittens</surname><given-names>Rolando A.</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Olivares-Navarrete</surname><given-names>Rene</given-names></name><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>McLachlan</surname><given-names>Taylor</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Cai</surname><given-names>Ye</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Hyzy</surname><given-names>Sharon L.</given-names></name><xref ref-type="aff" rid="A3">3</xref></contrib><contrib contrib-type="author"><name><surname>Schneider</surname><given-names>Jennifer M.</given-names></name><xref ref-type="aff" rid="A4">4</xref></contrib><contrib contrib-type="author"><name><surname>Schwartz</surname><given-names>Zvi</given-names></name><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Sandhage</surname><given-names>Kenneth H.</given-names></name><xref ref-type="aff" rid="A1">1</xref><xref ref-type="aff" rid="A5">5</xref></contrib><contrib contrib-type="author"><name><surname>Boyan</surname><given-names>Barbara D.</given-names></name><xref ref-type="aff" rid="A1">1</xref><xref ref-type="aff" rid="A2">2</xref><xref ref-type="aff" rid="A3">3</xref></contrib></contrib-group><aff id="A1"><label>1</label>School of Materials Science and Engineering, Georgia Institute of Technology, Atlanta, Georgia, USA</aff><aff id="A2"><label>2</label>Wallace H. Coulter Department of Biomedical Engineering at Georgia Tech and Emory University, Georgia Institute of Technology, Atlanta, GA, USA</aff><aff id="A3"><label>3</label>School of Biology, Georgia Institute of Technology, Atlanta, Georgia</aff><aff id="A4"><label>4</label>Titan Spine LLC, Mequon, Wisconsin</aff><aff id="A5"><label>5</label>School of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, Georgia, USA</aff><author-notes><corresp id="FN1">Address for Correspondence: Barbara D. Boyan, Ph.D., Institute for Bioengineering and Bioscience, Georgia Institute of Technology, 315 Ferst Drive, NW (Suite 1108), Atlanta, GA 30332-0363, Phone: 404-385-4108, FAX: 404-894-2291, <email>barbara.boyan@bme.gatech.edu</email></corresp></author-notes><pub-date pub-type="nihms-submitted"><day>25</day><month>2</month><year>2013</year></pub-date><pub-date pub-type="epub"><day>16</day><month>9</month><year>2012</year></pub-date><pub-date pub-type="ppub"><month>12</month><year>2012</year></pub-date><pub-date pub-type="pmc-release"><day>01</day><month>12</month><year>2013</year></pub-date><volume>33</volume><issue>35</issue><fpage>8986</fpage><lpage>8994</lpage><permissions><copyright-statement>© 2012 Elsevier Ltd. All rights reserved.</copyright-statement><copyright-year>2012</copyright-year></permissions><abstract><p id="P1">Surface structural modifications at the micrometer and nanometer scales have driven improved success rates of dental and orthopaedic implants by mimicking the hierarchical structure of bone. However, how initial osteoblast-lineage cells populating an implant surface respond to different hierarchical surface topographical cues remains to be elucidated, with bone marrow mesenchymal stem cells (MSCs) or immature osteoblasts as possible initial colonizers. Here we show that in the absence of any exogenous soluble factors, osteoblastic maturation of primary human osteoblasts (HOBs) but not osteoblastic differentiation of MSCs is strongly influenced by nanostructures superimposed onto a microrough Ti6Al4V (TiAlV) alloy. The sensitivity of osteoblasts to both surface microroughness and nanostructures led to a synergistic effect on maturation and local factor production. Osteoblastic differentiation of MSCs was sensitive to TiAlV surface microroughness with respect to production of differentiation markers, but no further enhancement was found when cultured on micro/nanostructured surfaces. Superposition of nanostructures to microroughened surfaces affected final MSC numbers and enhanced production of vascular endothelial growth factor (VEGF) but the magnitude of the response was lower than for HOB cultures. Our results suggest that the differentiation state of osteoblast-lineage cells determines the recognition of surface nanostructures and subsequent cell response, which has implications for clinical evaluation of new implant surface nanomodifications.</p></abstract><kwd-group><kwd>(4 to 6) metallic implants</kwd><kwd>osteointegration</kwd><kwd>titanium aluminum vanadium alloy</kwd><kwd>bone</kwd><kwd>nanostructures</kwd><kwd>osteoblast differentiation</kwd></kwd-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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