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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">A Cross-sectional Assessment of Biomarker Levels around Implants Versus Natural Teeth in Periodontal Maintenance Patients</title><author><name sortKey="Recker, Erica N" sort="Recker, Erica N" uniqKey="Recker E" first="Erica N." last="Recker">Erica N. Recker</name><affiliation><nlm:aff id="A1">Dows Institute of Dental Research, University of Iowa College of Dentistry, Iowa City, IA 52242</nlm:aff></affiliation></author><author><name sortKey="Avila Ortiz, Gustavo" sort="Avila Ortiz, Gustavo" uniqKey="Avila Ortiz G" first="Gustavo" last="Avila-Ortiz">Gustavo Avila-Ortiz</name><affiliation><nlm:aff id="A2">Department of Periodontics, University of Iowa College of Dentistry, Iowa City, IA 52242</nlm:aff></affiliation></author><author><name sortKey="Fischer, Carol L" sort="Fischer, Carol L" uniqKey="Fischer C" first="Carol L." last="Fischer">Carol L. Fischer</name><affiliation><nlm:aff id="A1">Dows Institute of Dental Research, University of Iowa College of Dentistry, Iowa City, IA 52242</nlm:aff></affiliation></author><author><name sortKey="Pagan Rivera, Keyla" sort="Pagan Rivera, Keyla" uniqKey="Pagan Rivera K" first="Keyla" last="Pagan-Rivera">Keyla Pagan-Rivera</name><affiliation><nlm:aff id="A3">Biostatistics and Research Design, University of Iowa College of Dentistry, Iowa City, IA 52242</nlm:aff></affiliation><affiliation><nlm:aff id="A4">Department of Biostatistics, University of Iowa College of Public Health, Iowa City, IA 52242</nlm:aff></affiliation></author><author><name sortKey="Brogden, Kim A" sort="Brogden, Kim A" uniqKey="Brogden K" first="Kim A." last="Brogden">Kim A. Brogden</name><affiliation><nlm:aff id="A1">Dows Institute of Dental Research, University of Iowa College of Dentistry, Iowa City, IA 52242</nlm:aff></affiliation><affiliation><nlm:aff id="A2">Department of Periodontics, University of Iowa College of Dentistry, Iowa City, IA 52242</nlm:aff></affiliation></author><author><name sortKey="Dawson, Deborah V" sort="Dawson, Deborah V" uniqKey="Dawson D" first="Deborah V." last="Dawson">Deborah V. Dawson</name><affiliation><nlm:aff id="A1">Dows Institute of Dental Research, University of Iowa College of Dentistry, Iowa City, IA 52242</nlm:aff></affiliation><affiliation><nlm:aff id="A3">Biostatistics and Research Design, University of Iowa College of Dentistry, Iowa City, IA 52242</nlm:aff></affiliation></author><author><name sortKey="Elangovan, Satheesh" sort="Elangovan, Satheesh" uniqKey="Elangovan S" first="Satheesh" last="Elangovan">Satheesh Elangovan</name><affiliation><nlm:aff id="A2">Department of Periodontics, University of Iowa College of Dentistry, Iowa City, IA 52242</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">25269523</idno><idno type="pmc">4394381</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4394381</idno><idno type="RBID">PMC:4394381</idno><idno type="doi">10.1902/jop.2014.140354</idno><date when="2014">2014</date><idno type="wicri:Area/Pmc/Corpus">002704</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002704</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">A Cross-sectional Assessment of Biomarker Levels around Implants Versus Natural Teeth in Periodontal Maintenance Patients</title><author><name sortKey="Recker, Erica N" sort="Recker, Erica N" uniqKey="Recker E" first="Erica N." last="Recker">Erica N. Recker</name><affiliation><nlm:aff id="A1">Dows Institute of Dental Research, University of Iowa College of Dentistry, Iowa City, IA 52242</nlm:aff></affiliation></author><author><name sortKey="Avila Ortiz, Gustavo" sort="Avila Ortiz, Gustavo" uniqKey="Avila Ortiz G" first="Gustavo" last="Avila-Ortiz">Gustavo Avila-Ortiz</name><affiliation><nlm:aff id="A2">Department of Periodontics, University of Iowa College of Dentistry, Iowa City, IA 52242</nlm:aff></affiliation></author><author><name sortKey="Fischer, Carol L" sort="Fischer, Carol L" uniqKey="Fischer C" first="Carol L." last="Fischer">Carol L. Fischer</name><affiliation><nlm:aff id="A1">Dows Institute of Dental Research, University of Iowa College of Dentistry, Iowa City, IA 52242</nlm:aff></affiliation></author><author><name sortKey="Pagan Rivera, Keyla" sort="Pagan Rivera, Keyla" uniqKey="Pagan Rivera K" first="Keyla" last="Pagan-Rivera">Keyla Pagan-Rivera</name><affiliation><nlm:aff id="A3">Biostatistics and Research Design, University of Iowa College of Dentistry, Iowa City, IA 52242</nlm:aff></affiliation><affiliation><nlm:aff id="A4">Department of Biostatistics, University of Iowa College of Public Health, Iowa City, IA 52242</nlm:aff></affiliation></author><author><name sortKey="Brogden, Kim A" sort="Brogden, Kim A" uniqKey="Brogden K" first="Kim A." last="Brogden">Kim A. Brogden</name><affiliation><nlm:aff id="A1">Dows Institute of Dental Research, University of Iowa College of Dentistry, Iowa City, IA 52242</nlm:aff></affiliation><affiliation><nlm:aff id="A2">Department of Periodontics, University of Iowa College of Dentistry, Iowa City, IA 52242</nlm:aff></affiliation></author><author><name sortKey="Dawson, Deborah V" sort="Dawson, Deborah V" uniqKey="Dawson D" first="Deborah V." last="Dawson">Deborah V. Dawson</name><affiliation><nlm:aff id="A1">Dows Institute of Dental Research, University of Iowa College of Dentistry, Iowa City, IA 52242</nlm:aff></affiliation><affiliation><nlm:aff id="A3">Biostatistics and Research Design, University of Iowa College of Dentistry, Iowa City, IA 52242</nlm:aff></affiliation></author><author><name sortKey="Elangovan, Satheesh" sort="Elangovan, Satheesh" uniqKey="Elangovan S" first="Satheesh" last="Elangovan">Satheesh Elangovan</name><affiliation><nlm:aff id="A2">Department of Periodontics, University of Iowa College of Dentistry, Iowa City, IA 52242</nlm:aff></affiliation></author></analytic><series><title level="j">Journal of periodontology</title><idno type="ISSN">0022-3492</idno><idno type="eISSN">1943-3670</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="S1"><title>Background</title><p id="P1">Recent studies point to the clinical utility of using peri-implant sulcular fluid (PISF) as a valuable diagnostic aid for monitoring peri-implant tissue health. The objectives of this study were to determine the levels of key biomarkers in PISF in periodontal maintenance participants and compare them to their corresponding levels in gingival crevicular fluid (GCF) obtained from the same participants.</p></sec><sec id="S2"><title>Methods</title><p id="P2">PISF and GCF were collected from an implant and a contralateral natural tooth, after the clinical examination of 73 participants. The levels of interleukin (IL)-1α, IL-1β, IL-6, IL-8, IL-10, IL-12, IL-17A, tumor necrosis factor (TNF)-α, C-reactive protein (CRP), osteoprotegerin (OPG), leptin, and adiponectin were determined using multiplex proteomic immunoassays. The correlation of biomarker concentrations between GCF versus PISF, within GCF or PISF, and with several covariates (age, brushing frequency, days since professional cleaning, probing depth and plaque index) were also determined.</p></sec><sec id="S3"><title>Results</title><p id="P3">Significantly higher levels of IL-17A (p=0.02) and TNF-α (p=0.03) were noted in PISF, when compared to their levels in GCF. Significant positive correlations were noted between the concentrations of cytokines in PISF versus their levels in GCF. Among the covariates, significant positive correlation was noted between mean probing depths around implants and levels of IL-1β (p < 0.05) and IL-8 levels (p < 0.05) in PISF.</p></sec><sec id="S4"><title>Conclusions</title><p id="P4">The results of this study point to the differential expression of specific biomarkers in GCF versus their levels in PISF in periodontal maintenance patients, which is critical information prior to establishing PISF as a diagnostic fluid to monitor peri-implant health.</p></sec></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">8000345</journal-id><journal-id journal-id-type="pubmed-jr-id">5144</journal-id><journal-id journal-id-type="nlm-ta">J Periodontol</journal-id><journal-id journal-id-type="iso-abbrev">J. Periodontol.</journal-id><journal-title-group><journal-title>Journal of periodontology</journal-title></journal-title-group><issn pub-type="ppub">0022-3492</issn><issn pub-type="epub">1943-3670</issn></journal-meta><article-meta><article-id pub-id-type="pmid">25269523</article-id><article-id pub-id-type="pmc">4394381</article-id><article-id pub-id-type="doi">10.1902/jop.2014.140354</article-id><article-id pub-id-type="manuscript">NIHMS677343</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>A Cross-sectional Assessment of Biomarker Levels around Implants Versus Natural Teeth in Periodontal Maintenance Patients</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Recker</surname><given-names>Erica N.</given-names></name><degrees>BS</degrees><xref ref-type="aff" rid="A1">*</xref></contrib><contrib contrib-type="author"><name><surname>Avila-Ortiz</surname><given-names>Gustavo</given-names></name><degrees>DDS, MS, PhD</degrees><xref ref-type="aff" rid="A2">†</xref></contrib><contrib contrib-type="author"><name><surname>Fischer</surname><given-names>Carol L.</given-names></name><degrees>PhD</degrees><xref ref-type="aff" rid="A1">*</xref></contrib><contrib contrib-type="author"><name><surname>Pagan-Rivera</surname><given-names>Keyla</given-names></name><degrees>MS</degrees><xref ref-type="aff" rid="A3">§</xref><xref ref-type="aff" rid="A4">‡</xref></contrib><contrib contrib-type="author"><name><surname>Brogden</surname><given-names>Kim A.</given-names></name><degrees>PhD</degrees><xref ref-type="aff" rid="A1">*</xref><xref ref-type="aff" rid="A2">†</xref></contrib><contrib contrib-type="author"><name><surname>Dawson</surname><given-names>Deborah V.</given-names></name><degrees>PhD</degrees><xref ref-type="aff" rid="A1">*</xref><xref ref-type="aff" rid="A3">§</xref></contrib><contrib contrib-type="author"><name><surname>Elangovan</surname><given-names>Satheesh</given-names></name><degrees>BDS, ScD, DMSc</degrees><xref ref-type="aff" rid="A2">†</xref></contrib></contrib-group><aff id="A1"><label>*</label>Dows Institute of Dental Research, University of Iowa College of Dentistry, Iowa City, IA 52242</aff><aff id="A2"><label>†</label>Department of Periodontics, University of Iowa College of Dentistry, Iowa City, IA 52242</aff><aff id="A3"><label>§</label>Biostatistics and Research Design, University of Iowa College of Dentistry, Iowa City, IA 52242</aff><aff id="A4"><label>‡</label>Department of Biostatistics, University of Iowa College of Public Health, Iowa City, IA 52242</aff><author-notes><corresp id="cor1"><bold>Corresponding Author</bold>: Dr. Satheesh Elangovan, Assistant Professor, Department of Periodontics, The University of Iowa College of Dentistry, S464, Iowa City, IA - 52242, Tel: 319 335 7543 / Fax: 319 335 7239, <email>satheesh-elangovan@uiowa.edu</email></corresp></author-notes><pub-date pub-type="nihms-submitted"><day>4</day><month>4</month><year>2015</year></pub-date><pub-date pub-type="epub"><day>30</day><month>9</month><year>2014</year></pub-date><pub-date pub-type="ppub"><month>2</month><year>2015</year></pub-date><pub-date pub-type="pmc-release"><day>01</day><month>2</month><year>2016</year></pub-date><volume>86</volume><issue>2</issue><fpage>264</fpage><lpage>272</lpage><pmc-comment>elocation-id from pubmed: 10.1902/jop.2014.140354</pmc-comment>
<abstract><sec id="S1"><title>Background</title><p id="P1">Recent studies point to the clinical utility of using peri-implant sulcular fluid (PISF) as a valuable diagnostic aid for monitoring peri-implant tissue health. The objectives of this study were to determine the levels of key biomarkers in PISF in periodontal maintenance participants and compare them to their corresponding levels in gingival crevicular fluid (GCF) obtained from the same participants.</p></sec><sec id="S2"><title>Methods</title><p id="P2">PISF and GCF were collected from an implant and a contralateral natural tooth, after the clinical examination of 73 participants. The levels of interleukin (IL)-1α, IL-1β, IL-6, IL-8, IL-10, IL-12, IL-17A, tumor necrosis factor (TNF)-α, C-reactive protein (CRP), osteoprotegerin (OPG), leptin, and adiponectin were determined using multiplex proteomic immunoassays. The correlation of biomarker concentrations between GCF versus PISF, within GCF or PISF, and with several covariates (age, brushing frequency, days since professional cleaning, probing depth and plaque index) were also determined.</p></sec><sec id="S3"><title>Results</title><p id="P3">Significantly higher levels of IL-17A (p=0.02) and TNF-α (p=0.03) were noted in PISF, when compared to their levels in GCF. Significant positive correlations were noted between the concentrations of cytokines in PISF versus their levels in GCF. Among the covariates, significant positive correlation was noted between mean probing depths around implants and levels of IL-1β (p < 0.05) and IL-8 levels (p < 0.05) in PISF.</p></sec><sec id="S4"><title>Conclusions</title><p id="P4">The results of this study point to the differential expression of specific biomarkers in GCF versus their levels in PISF in periodontal maintenance patients, which is critical information prior to establishing PISF as a diagnostic fluid to monitor peri-implant health.</p></sec></abstract><kwd-group><kwd>Gingival crevicular fluid</kwd><kwd>dental implants</kwd><kwd>peri-implantitis</kwd><kwd>biological markers</kwd></kwd-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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