Effect of Antimicrobial Intervention on Oral Microbiota Associated with Early Childhood Caries
Identifieur interne : 002693 ( Pmc/Corpus ); précédent : 002692; suivant : 002694Effect of Antimicrobial Intervention on Oral Microbiota Associated with Early Childhood Caries
Auteurs : Yihong Li ; Anne TannerSource :
- Pediatric dentistry [ 0164-1263 ] ; 2015.
Abstract
The aim of this systematic literature review was to identify research-based evidence for an effect of antimicrobial therapeutic approaches on the cariogenic microbiota and early childhood caries (ECC) outcomes. Additionally, we reviewed methods used to perform microbial assessments in clinical studies of ECC.
Multiple database searches were conducted; only clinical cohort studies and randomized controlled trials published from 1998 to 2014 were selected for the review. A total of 471 titles and abstracts were identified; 114 studies met the inclusion criteria for a full review, and finally 41 studies were selected for the meta-analyses.
Moderate reductions in cariogenic bacterial levels, mainly in mutans streptococci (MS), were demonstrated following the use of antimicrobial agents. The results varied depending on the different approaches used. In most of the reviewed studies MS levels were reduced after treatment, but the bacterial regrowth occurred once the treatment had ceased, and new caries lesions developed, particularly in high-risk children. Relatively consistent findings suggested that anti-cariogenic-microbial interventions in mothers significantly reduced MS acquisition by children. However, studies of the long-term benefits of ECC prevention are lacking.
Based on the meta-analyses, antimicrobial interventions and treatments show temporary reductions in MS colonization levels. However, insufficient evidence suggest that the approaches used produced sustainable effects on cariogenic microbial colonization, caries reduction, and ECC prevention.
Url:
PubMed: 26063552
PubMed Central: 4485441
Links to Exploration step
PMC:4485441Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Effect of Antimicrobial Intervention on Oral Microbiota Associated with Early Childhood Caries</title>
<author><name sortKey="Li, Yihong" sort="Li, Yihong" uniqKey="Li Y" first="Yihong" last="Li">Yihong Li</name>
<affiliation><nlm:aff id="A1">Professor and Director, Department of Basic Science and Craniofacial biology, New York University School of Dentistry, 345 E. 24th Street, New York, NY 10010, Tel: (212) 998-9607/ Fax: (212) 995-4087</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Tanner, Anne" sort="Tanner, Anne" uniqKey="Tanner A" first="Anne" last="Tanner">Anne Tanner</name>
<affiliation><nlm:aff id="A2">Senior member of the staff, Department of Microbiology, The Forsyth Institute, Associate Professor, Department of Oral Medicine, Infection, and Immunity, Harvard School of Dental Medicine, 245 First Street, Cambridge, MA, 02142, Phone (617) 892-8285 /FAX: (617) 892-8510</nlm:aff>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">26063552</idno>
<idno type="pmc">4485441</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4485441</idno>
<idno type="RBID">PMC:4485441</idno>
<date when="2015">2015</date>
<idno type="wicri:Area/Pmc/Corpus">002693</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002693</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Effect of Antimicrobial Intervention on Oral Microbiota Associated with Early Childhood Caries</title>
<author><name sortKey="Li, Yihong" sort="Li, Yihong" uniqKey="Li Y" first="Yihong" last="Li">Yihong Li</name>
<affiliation><nlm:aff id="A1">Professor and Director, Department of Basic Science and Craniofacial biology, New York University School of Dentistry, 345 E. 24th Street, New York, NY 10010, Tel: (212) 998-9607/ Fax: (212) 995-4087</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Tanner, Anne" sort="Tanner, Anne" uniqKey="Tanner A" first="Anne" last="Tanner">Anne Tanner</name>
<affiliation><nlm:aff id="A2">Senior member of the staff, Department of Microbiology, The Forsyth Institute, Associate Professor, Department of Oral Medicine, Infection, and Immunity, Harvard School of Dental Medicine, 245 First Street, Cambridge, MA, 02142, Phone (617) 892-8285 /FAX: (617) 892-8510</nlm:aff>
</affiliation>
</author>
</analytic>
<series><title level="j">Pediatric dentistry</title>
<idno type="ISSN">0164-1263</idno>
<idno type="eISSN">1942-5473</idno>
<imprint><date when="2015">2015</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><sec id="S1"><title>Purpose</title>
<p id="P1">The aim of this systematic literature review was to identify research-based evidence for an effect of antimicrobial therapeutic approaches on the cariogenic microbiota and early childhood caries (ECC) outcomes. Additionally, we reviewed methods used to perform microbial assessments in clinical studies of ECC.</p>
</sec>
<sec id="S2"><title>Methods</title>
<p id="P2">Multiple database searches were conducted; only clinical cohort studies and randomized controlled trials published from 1998 to 2014 were selected for the review. A total of 471 titles and abstracts were identified; 114 studies met the inclusion criteria for a full review, and finally 41 studies were selected for the meta-analyses.</p>
</sec>
<sec id="S3"><title>Results</title>
<p id="P3">Moderate reductions in cariogenic bacterial levels, mainly in mutans streptococci (MS), were demonstrated following the use of antimicrobial agents. The results varied depending on the different approaches used. In most of the reviewed studies MS levels were reduced after treatment, but the bacterial regrowth occurred once the treatment had ceased, and new caries lesions developed, particularly in high-risk children. Relatively consistent findings suggested that anti-cariogenic-microbial interventions in mothers significantly reduced MS acquisition by children. However, studies of the long-term benefits of ECC prevention are lacking.</p>
</sec>
<sec id="S4"><title>Conclusion</title>
<p id="P4">Based on the meta-analyses, antimicrobial interventions and treatments show temporary reductions in MS colonization levels. However, insufficient evidence suggest that the approaches used produced sustainable effects on cariogenic microbial colonization, caries reduction, and ECC prevention.</p>
</sec>
</div>
</front>
</TEI>
<pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">7909102</journal-id>
<journal-id journal-id-type="pubmed-jr-id">6507</journal-id>
<journal-id journal-id-type="nlm-ta">Pediatr Dent</journal-id>
<journal-id journal-id-type="iso-abbrev">Pediatr Dent</journal-id>
<journal-title-group><journal-title>Pediatric dentistry</journal-title>
</journal-title-group>
<issn pub-type="ppub">0164-1263</issn>
<issn pub-type="epub">1942-5473</issn>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">26063552</article-id>
<article-id pub-id-type="pmc">4485441</article-id>
<article-id pub-id-type="manuscript">NIHMS681264</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Article</subject>
</subj-group>
</article-categories>
<title-group><article-title>Effect of Antimicrobial Intervention on Oral Microbiota Associated with Early Childhood Caries</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Li</surname>
<given-names>Yihong</given-names>
</name>
<degrees>DDS MPH DrPH</degrees>
<email>yihong.li@nyu.edu</email>
<xref ref-type="aff" rid="A1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Tanner</surname>
<given-names>Anne</given-names>
</name>
<degrees>BDS PhD</degrees>
<email>annetanner@forsyth.org</email>
<xref ref-type="aff" rid="A2">2</xref>
</contrib>
</contrib-group>
<aff id="A1"><label>1</label>
Professor and Director, Department of Basic Science and Craniofacial biology, New York University School of Dentistry, 345 E. 24th Street, New York, NY 10010, Tel: (212) 998-9607/ Fax: (212) 995-4087</aff>
<aff id="A2"><label>2</label>
Senior member of the staff, Department of Microbiology, The Forsyth Institute, Associate Professor, Department of Oral Medicine, Infection, and Immunity, Harvard School of Dental Medicine, 245 First Street, Cambridge, MA, 02142, Phone (617) 892-8285 /FAX: (617) 892-8510</aff>
<pub-date pub-type="nihms-submitted"><day>22</day>
<month>4</month>
<year>2015</year>
</pub-date>
<pub-date pub-type="ppub"><year>2015</year>
</pub-date>
<pub-date pub-type="pmc-release"><day>29</day>
<month>6</month>
<year>2015</year>
</pub-date>
<volume>37</volume>
<issue>3</issue>
<fpage>226</fpage>
<lpage>244</lpage>
<abstract><sec id="S1"><title>Purpose</title>
<p id="P1">The aim of this systematic literature review was to identify research-based evidence for an effect of antimicrobial therapeutic approaches on the cariogenic microbiota and early childhood caries (ECC) outcomes. Additionally, we reviewed methods used to perform microbial assessments in clinical studies of ECC.</p>
</sec>
<sec id="S2"><title>Methods</title>
<p id="P2">Multiple database searches were conducted; only clinical cohort studies and randomized controlled trials published from 1998 to 2014 were selected for the review. A total of 471 titles and abstracts were identified; 114 studies met the inclusion criteria for a full review, and finally 41 studies were selected for the meta-analyses.</p>
</sec>
<sec id="S3"><title>Results</title>
<p id="P3">Moderate reductions in cariogenic bacterial levels, mainly in mutans streptococci (MS), were demonstrated following the use of antimicrobial agents. The results varied depending on the different approaches used. In most of the reviewed studies MS levels were reduced after treatment, but the bacterial regrowth occurred once the treatment had ceased, and new caries lesions developed, particularly in high-risk children. Relatively consistent findings suggested that anti-cariogenic-microbial interventions in mothers significantly reduced MS acquisition by children. However, studies of the long-term benefits of ECC prevention are lacking.</p>
</sec>
<sec id="S4"><title>Conclusion</title>
<p id="P4">Based on the meta-analyses, antimicrobial interventions and treatments show temporary reductions in MS colonization levels. However, insufficient evidence suggest that the approaches used produced sustainable effects on cariogenic microbial colonization, caries reduction, and ECC prevention.</p>
</sec>
</abstract>
<kwd-group><kwd>dental caries</kwd>
<kwd>oral microbiota</kwd>
<kwd>treatment effectiveness</kwd>
</kwd-group>
</article-meta>
</front>
</pmc>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Santé/explor/EdenteV2/Data/Pmc/Corpus
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 002693 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Pmc/Corpus/biblio.hfd -nk 002693 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Santé |area= EdenteV2 |flux= Pmc |étape= Corpus |type= RBID |clé= PMC:4485441 |texte= Effect of Antimicrobial Intervention on Oral Microbiota Associated with Early Childhood Caries }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Pmc/Corpus/RBID.i -Sk "pubmed:26063552" \ | HfdSelect -Kh $EXPLOR_AREA/Data/Pmc/Corpus/biblio.hfd \ | NlmPubMed2Wicri -a EdenteV2
![]() | This area was generated with Dilib version V0.6.32. | ![]() |