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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Characteristics Associated with Bone Mineral Density Responses to Alendronate in Men</title>
<author><name sortKey="Swenson, Erik D" sort="Swenson, Erik D" uniqKey="Swenson E" first="Erik D." last="Swenson">Erik D. Swenson</name>
<affiliation><nlm:aff id="A1">Mercy Arthritis and Osteoporosis Center, Urbandale, IA 50322</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Hansen, Karen E" sort="Hansen, Karen E" uniqKey="Hansen K" first="Karen E." last="Hansen">Karen E. Hansen</name>
<affiliation><nlm:aff id="A2">University of Wisconsin School of Medicine and Public Health</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Jones, Andrea N" sort="Jones, Andrea N" uniqKey="Jones A" first="Andrea N." last="Jones">Andrea N. Jones</name>
<affiliation><nlm:aff id="A2">University of Wisconsin School of Medicine and Public Health</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Li, Zhanhai" sort="Li, Zhanhai" uniqKey="Li Z" first="Zhanhai" last="Li">Zhanhai Li</name>
<affiliation><nlm:aff id="A3">University of Wisconsin Department of Biostatistics and Medical Informatics</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Baltz, Brooke" sort="Baltz, Brooke" uniqKey="Baltz B" first="Brooke" last="Baltz">Brooke Baltz</name>
<affiliation><nlm:aff id="A4">Northwestern Memorial Hospital, Chicago, IL 60611</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Schuna, Arthur A" sort="Schuna, Arthur A" uniqKey="Schuna A" first="Arthur A." last="Schuna">Arthur A. Schuna</name>
<affiliation><nlm:aff id="A5">William S. Middleton Veterans Affairs Medical Center</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Elliott, Mary E" sort="Elliott, Mary E" uniqKey="Elliott M" first="Mary E." last="Elliott">Mary E. Elliott</name>
<affiliation><nlm:aff id="A5">William S. Middleton Veterans Affairs Medical Center</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="A6">University of Wisconsin School of Pharmacy</nlm:aff>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">23494407</idno>
<idno type="pmc">4560467</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4560467</idno>
<idno type="RBID">PMC:4560467</idno>
<idno type="doi">10.1007/s00223-013-9715-9</idno>
<date when="2013">2013</date>
<idno type="wicri:Area/Pmc/Corpus">002691</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002691</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Characteristics Associated with Bone Mineral Density Responses to Alendronate in Men</title>
<author><name sortKey="Swenson, Erik D" sort="Swenson, Erik D" uniqKey="Swenson E" first="Erik D." last="Swenson">Erik D. Swenson</name>
<affiliation><nlm:aff id="A1">Mercy Arthritis and Osteoporosis Center, Urbandale, IA 50322</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Hansen, Karen E" sort="Hansen, Karen E" uniqKey="Hansen K" first="Karen E." last="Hansen">Karen E. Hansen</name>
<affiliation><nlm:aff id="A2">University of Wisconsin School of Medicine and Public Health</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Jones, Andrea N" sort="Jones, Andrea N" uniqKey="Jones A" first="Andrea N." last="Jones">Andrea N. Jones</name>
<affiliation><nlm:aff id="A2">University of Wisconsin School of Medicine and Public Health</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Li, Zhanhai" sort="Li, Zhanhai" uniqKey="Li Z" first="Zhanhai" last="Li">Zhanhai Li</name>
<affiliation><nlm:aff id="A3">University of Wisconsin Department of Biostatistics and Medical Informatics</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Baltz, Brooke" sort="Baltz, Brooke" uniqKey="Baltz B" first="Brooke" last="Baltz">Brooke Baltz</name>
<affiliation><nlm:aff id="A4">Northwestern Memorial Hospital, Chicago, IL 60611</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Schuna, Arthur A" sort="Schuna, Arthur A" uniqKey="Schuna A" first="Arthur A." last="Schuna">Arthur A. Schuna</name>
<affiliation><nlm:aff id="A5">William S. Middleton Veterans Affairs Medical Center</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Elliott, Mary E" sort="Elliott, Mary E" uniqKey="Elliott M" first="Mary E." last="Elliott">Mary E. Elliott</name>
<affiliation><nlm:aff id="A5">William S. Middleton Veterans Affairs Medical Center</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="A6">University of Wisconsin School of Pharmacy</nlm:aff>
</affiliation>
</author>
</analytic>
<series><title level="j">Calcified tissue international</title>
<idno type="ISSN">0171-967X</idno>
<idno type="eISSN">1432-0827</idno>
<imprint><date when="2013">2013</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><sec id="S1"><title>Background</title>
<p id="P1">Some patients experience reduced bone mineral density (BMD) despite bisphosphonate therapy. We performed a retrospective chart review study to detect factors associated with decreased BMD in men prescribed alendronate.</p>
</sec>
<sec id="S2"><title>Methods</title>
<p id="P2">Two investigators reviewed eligible medical records and used a standardized form to record potential characteristics predicting men’s response to alendronate. We analyzed patient characteristics associated with annualized change in hip and spine BMD (D-BMD).</p>
</sec>
<sec id="S3"><title>Results</title>
<p id="P3">Among 115 eligible men, 19 (17%) experienced significantly decreased BMD at the hip or spine, defined as a change exceeding precision error. Eleven men (10%) fractured during therapy. Spine D-BMD was positively associated with adherence to alendronate (R = 0.23, p=0.02) and inversely associated with baseline body weight (R = −0.21, p=0.03). Hip D-BMD was positively associated with annualized weight change (R = 0.19, p=0.0498) and negatively associated with patient age and number of concomitant medications (R = −0.21, p=0.03; R = −0.20, p = 0.03, respectively). In stepwise linear models, spine D-BMD was positively associated with alendronate adherence and multivitamin use, and negatively with baseline body weight. Hip D-BMD was negatively associated with age. Fracture during treatment was associated with fracture prior to therapy (p=0.03)</p>
</sec>
<sec id="S4"><title>Conclusions</title>
<p id="P4">In this small study of men prescribed alendronate, BMD response showed a positive association with adherence to therapy, weight gain, and use of a multivitamin. By contrast, older age, higher baseline body weight, and higher number of medications were each associated with a decrease in BMD. Larger studies are needed to confirm and extend these findings.</p>
</sec>
</div>
</front>
</TEI>
<pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">7905481</journal-id>
<journal-id journal-id-type="pubmed-jr-id">2713</journal-id>
<journal-id journal-id-type="nlm-ta">Calcif Tissue Int</journal-id>
<journal-id journal-id-type="iso-abbrev">Calcif. Tissue Int.</journal-id>
<journal-title-group><journal-title>Calcified tissue international</journal-title>
</journal-title-group>
<issn pub-type="ppub">0171-967X</issn>
<issn pub-type="epub">1432-0827</issn>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">23494407</article-id>
<article-id pub-id-type="pmc">4560467</article-id>
<article-id pub-id-type="doi">10.1007/s00223-013-9715-9</article-id>
<article-id pub-id-type="manuscript">NIHMS716746</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Article</subject>
</subj-group>
</article-categories>
<title-group><article-title>Characteristics Associated with Bone Mineral Density Responses to Alendronate in Men</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Swenson</surname>
<given-names>Erik D.</given-names>
</name>
<xref ref-type="aff" rid="A1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Hansen</surname>
<given-names>Karen E.</given-names>
</name>
<xref ref-type="aff" rid="A2">2</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Jones</surname>
<given-names>Andrea N.</given-names>
</name>
<xref ref-type="aff" rid="A2">2</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Li</surname>
<given-names>Zhanhai</given-names>
</name>
<xref ref-type="aff" rid="A3">3</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Baltz</surname>
<given-names>Brooke</given-names>
</name>
<xref ref-type="aff" rid="A4">4</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Schuna</surname>
<given-names>Arthur A.</given-names>
</name>
<xref ref-type="aff" rid="A5">5</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Elliott</surname>
<given-names>Mary E.</given-names>
</name>
<xref ref-type="aff" rid="A5">5</xref>
<xref ref-type="aff" rid="A6">6</xref>
</contrib>
</contrib-group>
<aff id="A1"><label>1</label>
Mercy Arthritis and Osteoporosis Center, Urbandale, IA 50322</aff>
<aff id="A2"><label>2</label>
University of Wisconsin School of Medicine and Public Health</aff>
<aff id="A3"><label>3</label>
University of Wisconsin Department of Biostatistics and Medical Informatics</aff>
<aff id="A4"><label>4</label>
Northwestern Memorial Hospital, Chicago, IL 60611</aff>
<aff id="A5"><label>5</label>
William S. Middleton Veterans Affairs Medical Center</aff>
<aff id="A6"><label>6</label>
University of Wisconsin School of Pharmacy</aff>
<author-notes><corresp id="FN1">Corresponding Author: Mary E. Elliott, Pharm.D., Ph.D., Associate Professor, University of Wisconsin School of Pharmacy, 777 Highland Avenue, Madison, WI 53705, <email>meelliott@pharmacy.wisc.edu</email>
, Telephone: 608-265-9765, FAX: 608-265-5421</corresp>
</author-notes>
<pub-date pub-type="nihms-submitted"><day>31</day>
<month>8</month>
<year>2015</year>
</pub-date>
<pub-date pub-type="epub"><day>15</day>
<month>3</month>
<year>2013</year>
</pub-date>
<pub-date pub-type="ppub"><month>6</month>
<year>2013</year>
</pub-date>
<pub-date pub-type="pmc-release"><day>04</day>
<month>9</month>
<year>2015</year>
</pub-date>
<volume>92</volume>
<issue>6</issue>
<fpage>548</fpage>
<lpage>556</lpage>
<pmc-comment>elocation-id from pubmed: 10.1007/s00223-013-9715-9</pmc-comment>
<abstract><sec id="S1"><title>Background</title>
<p id="P1">Some patients experience reduced bone mineral density (BMD) despite bisphosphonate therapy. We performed a retrospective chart review study to detect factors associated with decreased BMD in men prescribed alendronate.</p>
</sec>
<sec id="S2"><title>Methods</title>
<p id="P2">Two investigators reviewed eligible medical records and used a standardized form to record potential characteristics predicting men’s response to alendronate. We analyzed patient characteristics associated with annualized change in hip and spine BMD (D-BMD).</p>
</sec>
<sec id="S3"><title>Results</title>
<p id="P3">Among 115 eligible men, 19 (17%) experienced significantly decreased BMD at the hip or spine, defined as a change exceeding precision error. Eleven men (10%) fractured during therapy. Spine D-BMD was positively associated with adherence to alendronate (R = 0.23, p=0.02) and inversely associated with baseline body weight (R = −0.21, p=0.03). Hip D-BMD was positively associated with annualized weight change (R = 0.19, p=0.0498) and negatively associated with patient age and number of concomitant medications (R = −0.21, p=0.03; R = −0.20, p = 0.03, respectively). In stepwise linear models, spine D-BMD was positively associated with alendronate adherence and multivitamin use, and negatively with baseline body weight. Hip D-BMD was negatively associated with age. Fracture during treatment was associated with fracture prior to therapy (p=0.03)</p>
</sec>
<sec id="S4"><title>Conclusions</title>
<p id="P4">In this small study of men prescribed alendronate, BMD response showed a positive association with adherence to therapy, weight gain, and use of a multivitamin. By contrast, older age, higher baseline body weight, and higher number of medications were each associated with a decrease in BMD. Larger studies are needed to confirm and extend these findings.</p>
</sec>
</abstract>
<kwd-group><kwd>adherence</kwd>
<kwd>efficacy</kwd>
<kwd>men</kwd>
<kwd>osteoporosis</kwd>
<kwd>treatment</kwd>
</kwd-group>
</article-meta>
</front>
</pmc>
</record>
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