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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">The effects of elevated hemoglobin A<sub>1c</sub> in patients with type 2 diabetes mellitus on dental implants</title><author><name sortKey="Oates, Thomas W" sort="Oates, Thomas W" uniqKey="Oates T" first="Thomas W." last="Oates">Thomas W. Oates</name></author><author><name sortKey="Galloway, Patrick" sort="Galloway, Patrick" uniqKey="Galloway P" first="Patrick" last="Galloway">Patrick Galloway</name></author><author><name sortKey="Alexander, Peggy" sort="Alexander, Peggy" uniqKey="Alexander P" first="Peggy" last="Alexander">Peggy Alexander</name></author><author><name sortKey="Green, Adriana Vargas" sort="Green, Adriana Vargas" uniqKey="Green A" first="Adriana Vargas" last="Green">Adriana Vargas Green</name></author><author><name sortKey="Huynh Ba, Guy" sort="Huynh Ba, Guy" uniqKey="Huynh Ba G" first="Guy" last="Huynh-Ba">Guy Huynh-Ba</name></author><author><name sortKey="Feine, Jocelyn" sort="Feine, Jocelyn" uniqKey="Feine J" first="Jocelyn" last="Feine">Jocelyn Feine</name></author><author><name sortKey="Mcmahan, C Alex" sort="Mcmahan, C Alex" uniqKey="Mcmahan C" first="C. Alex" last="Mcmahan">C. Alex Mcmahan</name></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">25429035</idno><idno type="pmc">4403726</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4403726</idno><idno type="RBID">PMC:4403726</idno><idno type="doi">10.14219/jada.2014.93</idno><date when="2014">2014</date><idno type="wicri:Area/Pmc/Corpus">002678</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002678</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">The effects of elevated hemoglobin A<sub>1c</sub> in patients with type 2 diabetes mellitus on dental implants</title><author><name sortKey="Oates, Thomas W" sort="Oates, Thomas W" uniqKey="Oates T" first="Thomas W." last="Oates">Thomas W. Oates</name></author><author><name sortKey="Galloway, Patrick" sort="Galloway, Patrick" uniqKey="Galloway P" first="Patrick" last="Galloway">Patrick Galloway</name></author><author><name sortKey="Alexander, Peggy" sort="Alexander, Peggy" uniqKey="Alexander P" first="Peggy" last="Alexander">Peggy Alexander</name></author><author><name sortKey="Green, Adriana Vargas" sort="Green, Adriana Vargas" uniqKey="Green A" first="Adriana Vargas" last="Green">Adriana Vargas Green</name></author><author><name sortKey="Huynh Ba, Guy" sort="Huynh Ba, Guy" uniqKey="Huynh Ba G" first="Guy" last="Huynh-Ba">Guy Huynh-Ba</name></author><author><name sortKey="Feine, Jocelyn" sort="Feine, Jocelyn" uniqKey="Feine J" first="Jocelyn" last="Feine">Jocelyn Feine</name></author><author><name sortKey="Mcmahan, C Alex" sort="Mcmahan, C Alex" uniqKey="Mcmahan C" first="C. Alex" last="Mcmahan">C. Alex Mcmahan</name></author></analytic><series><title level="j">Journal of the American Dental Association (1939)</title><idno type="ISSN">0002-8177</idno><idno type="eISSN">1943-4723</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="S1"><title>Background</title><p id="P1">The authors conducted a prospective cohort study to determine whether poor glycemic control is a contraindication to implant therapy in patients with type 2 diabetes.</p></sec><sec id="S2"><title>Methods</title><p id="P2">The study sample consisted of 117 edentulous patients, each of whom received two mandibular implants, for a total of 234 implants. Implant-retained mandibular overdentures were loaded after a four-month healing period and followed up for an additional one year. The authors assessed implant survival and stability (by means of resonance frequency analysis) relative to glycated hemoglobin A<sub>1c</sub> (HbA<sub>1c</sub>) levels, with baseline levels up to 11.1 percent and levels as high as 13.3 percent over one year.</p></sec><sec id="S3"><title>Results</title><p id="P3">Implant survival rates for 110 of 117 patients who were followed up for one year after loading were <italic>99.0</italic> percent, 98.9 percent and 100 percent, respectively, for patients who did not have diabetes (n = 47), those with well-controlled diabetes (n = 44) and those with poorly controlled diabetes (n = 19). The authors considered the seven patients lost to follow-up as having had failed implants; consequently, their conservative estimates of survival rates in the three groups were 93.0 percent, 92.6 percent and 95.0 percent (<italic>P</italic> = .6510) . Two implants failed at four weeks, one in the nondiabetes group and the other in the well-con trolled diabetes group. Delays in implant stabilization were related directly to poor glycemic control.</p></sec><sec id="S4"><title>Conclusions</title><p id="P4">The results of this study indicate that elevated HbA<sub>1c</sub> levels in patients with type 2 diabetes were not associated with altered implant survival one year after loading. However, alterations in early bone healing and implant stability were associated with hyperglycemia.</p></sec><sec id="S5"><title>Practical Implications</title><p id="P5">Within the clinical parameters of this study, the findings indicate likely implant success among patients with type 2 diabetes who lacked good glycemic control. Further investigation, including longer-term evaluation, is needed.</p></sec></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">7503060</journal-id><journal-id journal-id-type="pubmed-jr-id">4439</journal-id><journal-id journal-id-type="nlm-ta">J Am Dent Assoc</journal-id><journal-id journal-id-type="iso-abbrev">J Am Dent Assoc</journal-id><journal-title-group><journal-title>Journal of the American Dental Association (1939)</journal-title></journal-title-group><issn pub-type="ppub">0002-8177</issn><issn pub-type="epub">1943-4723</issn></journal-meta><article-meta><article-id pub-id-type="pmid">25429035</article-id><article-id pub-id-type="pmc">4403726</article-id><article-id pub-id-type="doi">10.14219/jada.2014.93</article-id><article-id pub-id-type="manuscript">NIHMS679070</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>The effects of elevated hemoglobin A<sub>1c</sub> in patients with type 2 diabetes mellitus on dental implants</article-title><subtitle>Survival and stability at one year</subtitle></title-group><contrib-group><contrib contrib-type="author"><name><surname>Oates</surname><given-names>Thomas W.</given-names><suffix>Jr.</suffix></name><degrees>DMD, PhD</degrees><role>professor</role><aff id="A1">Department of Periodontics, School of Dentistry, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, MCS 7888, San Antonio, Texas 78229-3900</aff></contrib><contrib contrib-type="author"><name><surname>Galloway</surname><given-names>Patrick</given-names></name><degrees>DDS, MS</degrees><role>former resident</role><aff id="A2">Department of Periodontics, School of Dentistry, University of Texas Health Science Center at San Antonio</aff></contrib><contrib contrib-type="author"><name><surname>Alexander</surname><given-names>Peggy</given-names></name><degrees>DDS, MPH</degrees><role>clinical professor</role><aff id="A3">Department of Periodontics, School of Dentistry, University of Texas Health Science Center at San Antonio</aff></contrib><contrib contrib-type="author"><name><surname>Green</surname><given-names>Adriana Vargas</given-names></name><degrees>DDS, MPH, MS</degrees><role>an associate professor</role><aff id="A4">Department of Comprehensive Dentistry, School of Dentistry, University of Texas Health Science Center at San Antonio</aff></contrib><contrib contrib-type="author"><name><surname>Huynh-Ba</surname><given-names>Guy</given-names></name><degrees>DDS, Dr med dent, MS</degrees><role>an associate professor</role><aff id="A5">Department of Periodontics, School of Dentistry, University of Texas Health Science Center at San Antonio</aff></contrib><contrib contrib-type="author"><name><surname>Feine</surname><given-names>Jocelyn</given-names></name><degrees>DDS</degrees><role>professor</role><aff id="A6">Oral Health and Society Research Unit, Faculty of Dentistry, McGill University, Montreal, Quebec, Canada</aff></contrib><contrib contrib-type="author"><name><surname>McMahan</surname><given-names>C. Alex</given-names></name><degrees>PhD</degrees><role>professor</role><aff id="A7">Department of Pathology, University of Texas Health Science Center at San Antonio</aff></contrib></contrib-group><author-notes><corresp id="CR1">Address correspondence to Dr. Oates <email>oates@uthscsa.edu</email>.</corresp></author-notes><pub-date pub-type="nihms-submitted"><day>10</day><month>4</month><year>2015</year></pub-date><pub-date pub-type="ppub"><month>12</month><year>2014</year></pub-date><pub-date pub-type="pmc-release"><day>20</day><month>4</month><year>2015</year></pub-date><volume>145</volume><issue>12</issue><fpage>1218</fpage><lpage>1226</lpage><pmc-comment>elocation-id from pubmed: 10.14219/jada.2014.93</pmc-comment>
<abstract><sec id="S1"><title>Background</title><p id="P1">The authors conducted a prospective cohort study to determine whether poor glycemic control is a contraindication to implant therapy in patients with type 2 diabetes.</p></sec><sec id="S2"><title>Methods</title><p id="P2">The study sample consisted of 117 edentulous patients, each of whom received two mandibular implants, for a total of 234 implants. Implant-retained mandibular overdentures were loaded after a four-month healing period and followed up for an additional one year. The authors assessed implant survival and stability (by means of resonance frequency analysis) relative to glycated hemoglobin A<sub>1c</sub> (HbA<sub>1c</sub>) levels, with baseline levels up to 11.1 percent and levels as high as 13.3 percent over one year.</p></sec><sec id="S3"><title>Results</title><p id="P3">Implant survival rates for 110 of 117 patients who were followed up for one year after loading were <italic>99.0</italic> percent, 98.9 percent and 100 percent, respectively, for patients who did not have diabetes (n = 47), those with well-controlled diabetes (n = 44) and those with poorly controlled diabetes (n = 19). The authors considered the seven patients lost to follow-up as having had failed implants; consequently, their conservative estimates of survival rates in the three groups were 93.0 percent, 92.6 percent and 95.0 percent (<italic>P</italic> = .6510) . Two implants failed at four weeks, one in the nondiabetes group and the other in the well-con trolled diabetes group. Delays in implant stabilization were related directly to poor glycemic control.</p></sec><sec id="S4"><title>Conclusions</title><p id="P4">The results of this study indicate that elevated HbA<sub>1c</sub> levels in patients with type 2 diabetes were not associated with altered implant survival one year after loading. However, alterations in early bone healing and implant stability were associated with hyperglycemia.</p></sec><sec id="S5"><title>Practical Implications</title><p id="P5">Within the clinical parameters of this study, the findings indicate likely implant success among patients with type 2 diabetes who lacked good glycemic control. Further investigation, including longer-term evaluation, is needed.</p></sec></abstract><kwd-group><kwd>Implantology</kwd><kwd>diabetes</kwd><kwd>bone biology</kwd><kwd>resonance frequency analysis</kwd><kwd>implant stability quotient</kwd></kwd-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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