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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Regenerate Healing Outcomes in Unilateral Mandibular Distraction Osteogenesis Using Quantitative Histomorphometry</title>
<author><name sortKey="Schwarz, Daniel A" sort="Schwarz, Daniel A" uniqKey="Schwarz D" first="Daniel A." last="Schwarz">Daniel A. Schwarz</name>
</author>
<author><name sortKey="Arman, Krikor G" sort="Arman, Krikor G" uniqKey="Arman K" first="Krikor G." last="Arman">Krikor G. Arman</name>
</author>
<author><name sortKey="Kakwan, Mehreen S" sort="Kakwan, Mehreen S" uniqKey="Kakwan M" first="Mehreen S." last="Kakwan">Mehreen S. Kakwan</name>
</author>
<author><name sortKey="Jamali, Ameen M" sort="Jamali, Ameen M" uniqKey="Jamali A" first="Ameen M." last="Jamali">Ameen M. Jamali</name>
</author>
<author><name sortKey="Elmeligy, Ayman A" sort="Elmeligy, Ayman A" uniqKey="Elmeligy A" first="Ayman A." last="Elmeligy">Ayman A. Elmeligy</name>
</author>
<author><name sortKey="Buchman, Steven R" sort="Buchman, Steven R" uniqKey="Buchman S" first="Steven R." last="Buchman">Steven R. Buchman</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">20463629</idno>
<idno type="pmc">4608224</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4608224</idno>
<idno type="RBID">PMC:4608224</idno>
<idno type="doi">10.1097/PRS.0b013e3181e3b351</idno>
<date when="2010">2010</date>
<idno type="wicri:Area/Pmc/Corpus">002672</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002672</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Regenerate Healing Outcomes in Unilateral Mandibular Distraction Osteogenesis Using Quantitative Histomorphometry</title>
<author><name sortKey="Schwarz, Daniel A" sort="Schwarz, Daniel A" uniqKey="Schwarz D" first="Daniel A." last="Schwarz">Daniel A. Schwarz</name>
</author>
<author><name sortKey="Arman, Krikor G" sort="Arman, Krikor G" uniqKey="Arman K" first="Krikor G." last="Arman">Krikor G. Arman</name>
</author>
<author><name sortKey="Kakwan, Mehreen S" sort="Kakwan, Mehreen S" uniqKey="Kakwan M" first="Mehreen S." last="Kakwan">Mehreen S. Kakwan</name>
</author>
<author><name sortKey="Jamali, Ameen M" sort="Jamali, Ameen M" uniqKey="Jamali A" first="Ameen M." last="Jamali">Ameen M. Jamali</name>
</author>
<author><name sortKey="Elmeligy, Ayman A" sort="Elmeligy, Ayman A" uniqKey="Elmeligy A" first="Ayman A." last="Elmeligy">Ayman A. Elmeligy</name>
</author>
<author><name sortKey="Buchman, Steven R" sort="Buchman, Steven R" uniqKey="Buchman S" first="Steven R." last="Buchman">Steven R. Buchman</name>
</author>
</analytic>
<series><title level="j">Plastic and reconstructive surgery</title>
<idno type="ISSN">0032-1052</idno>
<idno type="eISSN">1529-4242</idno>
<imprint><date when="2010">2010</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><sec id="S1"><title>Background</title>
<p id="P1">The authors’ goal was to ascertain regenerate bone-healing metrics using quantitative histomorphometry at a single consolidation period.</p>
</sec>
<sec id="S2"><title>Methods</title>
<p id="P2">Rats underwent either mandibular distraction osteogenesis (<italic>n=</italic>
7) or partially reduced fractures (<italic>n=</italic>
7); their contralateral mandibles were used as controls (<italic>n=</italic>
11). External fixators were secured and unilateral osteotomies performed, followed by either mandibular distraction osteogenesis (4 days’ latency, then 0.3 mm every 12 hours for 8 days; 5.1 mm) or partially reduced fractures (fixed immediately postoperatively; 2.1 mm); both groups underwent 4 weeks of consolidation. After tissue processing, bone volume/tissue volume ratio, osteoid volume/tissue volume ratio, and osteocyte count per high-power field were analyzed by means of quantitative histomorphometry.</p>
</sec>
<sec id="S3"><title>Results</title>
<p id="P3">Contralateral mandibles had statistically greater bone volume/tissue volume ratio and osteocyte count per high-power field compared with both mandibular distraction osteogenesis and partially reduced fractures by almost 50 percent, whereas osteoid volume/tissue volume ratio was statistically greater in both mandibular distraction osteogenesis specimens and partially reduced fractures compared with contralateral mandibles. No statistical difference in bone volume/tissue volume ratio, osteoid volume/tissue volume ratio, or osteocyte count per high-power field was found between mandibular distraction osteogenesis specimens and partially reduced fractures.</p>
</sec>
<sec id="S4"><title>Conclusions</title>
<p id="P4">The authors’ findings demonstrate significantly decreased bone quantity and maturity in mandibular distraction osteogenesis specimens and partially reduced fractures compared with contralateral mandibles using the clinically analogous protocols. If these results are extrapolated clinically, treatment strategies may require modification to ensure reliable, predictable, and improved outcomes.</p>
</sec>
</div>
</front>
</TEI>
<pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">1306050</journal-id>
<journal-id journal-id-type="pubmed-jr-id">6482</journal-id>
<journal-id journal-id-type="nlm-ta">Plast Reconstr Surg</journal-id>
<journal-id journal-id-type="iso-abbrev">Plast. Reconstr. Surg.</journal-id>
<journal-title-group><journal-title>Plastic and reconstructive surgery</journal-title>
</journal-title-group>
<issn pub-type="ppub">0032-1052</issn>
<issn pub-type="epub">1529-4242</issn>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">20463629</article-id>
<article-id pub-id-type="pmc">4608224</article-id>
<article-id pub-id-type="doi">10.1097/PRS.0b013e3181e3b351</article-id>
<article-id pub-id-type="manuscript">NIHMS725275</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Article</subject>
</subj-group>
</article-categories>
<title-group><article-title>Regenerate Healing Outcomes in Unilateral Mandibular Distraction Osteogenesis Using Quantitative Histomorphometry</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Schwarz</surname>
<given-names>Daniel A.</given-names>
</name>
<degrees>M.D.</degrees>
</contrib>
<contrib contrib-type="author"><name><surname>Arman</surname>
<given-names>Krikor G.</given-names>
</name>
<degrees>B.S.</degrees>
</contrib>
<contrib contrib-type="author"><name><surname>Kakwan</surname>
<given-names>Mehreen S.</given-names>
</name>
<degrees>B.S.</degrees>
</contrib>
<contrib contrib-type="author"><name><surname>Jamali</surname>
<given-names>Ameen M.</given-names>
</name>
<degrees>B.S.</degrees>
</contrib>
<contrib contrib-type="author"><name><surname>Elmeligy</surname>
<given-names>Ayman A.</given-names>
</name>
<degrees>M.D.</degrees>
</contrib>
<contrib contrib-type="author"><name><surname>Buchman</surname>
<given-names>Steven R.</given-names>
</name>
<degrees>M.D.</degrees>
</contrib>
<aff id="A1">University of Michigan Medical School, Ann Arbor, Mich.; University of Toledo, Toledo, Ohio; and Ain Shams University, Cairo, Egypt</aff>
</contrib-group>
<author-notes><corresp id="FN1"><bold><italic>Steven R. Buchman, M.D.</italic>
</bold>
, University of Michigan Medical School, 1500 East Medical Center Drive, Mott Children’s Hosptal, F7859, Ann Arbor, Mich. 48109-0219, <email>sbuchman@umich.edu</email>
</corresp>
</author-notes>
<pub-date pub-type="nihms-submitted"><day>30</day>
<month>9</month>
<year>2015</year>
</pub-date>
<pub-date pub-type="ppub"><month>9</month>
<year>2010</year>
</pub-date>
<pub-date pub-type="pmc-release"><day>16</day>
<month>10</month>
<year>2015</year>
</pub-date>
<volume>126</volume>
<issue>3</issue>
<fpage>795</fpage>
<lpage>805</lpage>
<pmc-comment>elocation-id from pubmed: 10.1097/PRS.0b013e3181e3b351</pmc-comment>
<abstract><sec id="S1"><title>Background</title>
<p id="P1">The authors’ goal was to ascertain regenerate bone-healing metrics using quantitative histomorphometry at a single consolidation period.</p>
</sec>
<sec id="S2"><title>Methods</title>
<p id="P2">Rats underwent either mandibular distraction osteogenesis (<italic>n=</italic>
7) or partially reduced fractures (<italic>n=</italic>
7); their contralateral mandibles were used as controls (<italic>n=</italic>
11). External fixators were secured and unilateral osteotomies performed, followed by either mandibular distraction osteogenesis (4 days’ latency, then 0.3 mm every 12 hours for 8 days; 5.1 mm) or partially reduced fractures (fixed immediately postoperatively; 2.1 mm); both groups underwent 4 weeks of consolidation. After tissue processing, bone volume/tissue volume ratio, osteoid volume/tissue volume ratio, and osteocyte count per high-power field were analyzed by means of quantitative histomorphometry.</p>
</sec>
<sec id="S3"><title>Results</title>
<p id="P3">Contralateral mandibles had statistically greater bone volume/tissue volume ratio and osteocyte count per high-power field compared with both mandibular distraction osteogenesis and partially reduced fractures by almost 50 percent, whereas osteoid volume/tissue volume ratio was statistically greater in both mandibular distraction osteogenesis specimens and partially reduced fractures compared with contralateral mandibles. No statistical difference in bone volume/tissue volume ratio, osteoid volume/tissue volume ratio, or osteocyte count per high-power field was found between mandibular distraction osteogenesis specimens and partially reduced fractures.</p>
</sec>
<sec id="S4"><title>Conclusions</title>
<p id="P4">The authors’ findings demonstrate significantly decreased bone quantity and maturity in mandibular distraction osteogenesis specimens and partially reduced fractures compared with contralateral mandibles using the clinically analogous protocols. If these results are extrapolated clinically, treatment strategies may require modification to ensure reliable, predictable, and improved outcomes.</p>
</sec>
</abstract>
</article-meta>
</front>
</pmc>
</record>
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