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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Association between serum antibodies to periodontal bacteria and rheumatoid factor in NHANES III</title><author><name sortKey="Goh, Charlene E" sort="Goh, Charlene E" uniqKey="Goh C" first="Charlene E." last="Goh">Charlene E. Goh</name><affiliation><nlm:aff id="A1">Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA</nlm:aff></affiliation></author><author><name sortKey="Kopp, Jacob" sort="Kopp, Jacob" uniqKey="Kopp J" first="Jacob" last="Kopp">Jacob Kopp</name><affiliation><nlm:aff id="A1">Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA</nlm:aff></affiliation></author><author><name sortKey="Papapanou, Panos N" sort="Papapanou, Panos N" uniqKey="Papapanou P" first="Panos N." last="Papapanou">Panos N. Papapanou</name><affiliation><nlm:aff id="A2">Division of Periodontics, Section of Oral and Diagnostic Sciences, College of Dental Medicine, Columbia University, USA</nlm:aff></affiliation></author><author><name sortKey="Molitor, Jerry A" sort="Molitor, Jerry A" uniqKey="Molitor J" first="Jerry A." last="Molitor">Jerry A. Molitor</name><affiliation><nlm:aff id="A3">Department of Medicine, University of Minnesota, Minneapolis, MN, USA</nlm:aff></affiliation></author><author><name sortKey="Demmer, Ryan T" sort="Demmer, Ryan T" uniqKey="Demmer R" first="Ryan T." last="Demmer">Ryan T. Demmer</name><affiliation><nlm:aff id="A1">Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">27110949</idno><idno type="pmc">5042803</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5042803</idno><idno type="RBID">PMC:5042803</idno><idno type="doi">10.1002/art.39724</idno><date when="2016">2016</date><idno type="wicri:Area/Pmc/Corpus">002666</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002666</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Association between serum antibodies to periodontal bacteria and rheumatoid factor in NHANES III</title><author><name sortKey="Goh, Charlene E" sort="Goh, Charlene E" uniqKey="Goh C" first="Charlene E." last="Goh">Charlene E. Goh</name><affiliation><nlm:aff id="A1">Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA</nlm:aff></affiliation></author><author><name sortKey="Kopp, Jacob" sort="Kopp, Jacob" uniqKey="Kopp J" first="Jacob" last="Kopp">Jacob Kopp</name><affiliation><nlm:aff id="A1">Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA</nlm:aff></affiliation></author><author><name sortKey="Papapanou, Panos N" sort="Papapanou, Panos N" uniqKey="Papapanou P" first="Panos N." last="Papapanou">Panos N. Papapanou</name><affiliation><nlm:aff id="A2">Division of Periodontics, Section of Oral and Diagnostic Sciences, College of Dental Medicine, Columbia University, USA</nlm:aff></affiliation></author><author><name sortKey="Molitor, Jerry A" sort="Molitor, Jerry A" uniqKey="Molitor J" first="Jerry A." last="Molitor">Jerry A. Molitor</name><affiliation><nlm:aff id="A3">Department of Medicine, University of Minnesota, Minneapolis, MN, USA</nlm:aff></affiliation></author><author><name sortKey="Demmer, Ryan T" sort="Demmer, Ryan T" uniqKey="Demmer R" first="Ryan T." last="Demmer">Ryan T. Demmer</name><affiliation><nlm:aff id="A1">Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA</nlm:aff></affiliation></author></analytic><series><title level="j">Arthritis & rheumatology (Hoboken, N.J.)</title><idno type="ISSN">2326-5191</idno><idno type="eISSN">2326-5205</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="S1"><title>Objective</title><p id="P1">Alterations in the microbiome, including the periodontal microbiome, may be a risk factor for rheumatoid arthritis (RA). Most studies that have analyzed this association are relatively small, focus primarily on a single periodontal pathogen (<italic>Porphyromonas gingivalis</italic>), and are not population-based. We investigated the association between elevated serum IgG antibodies to 19 periodontal species and the prevalence of rheumatoid factor (RF) in a large nationally representative sample of adults.</p></sec><sec id="S2"><title>Methods</title><p id="P2">The Third National Health and Nutrition Examination Survey is a cross-sectional sample of the non-institutionalized US population (n=33,994). Our study population included all dentate participants ≥60 years, who did not have RA as defined by a modified version of the American College of Rheumatology 1987 criteria, and had complete data for both serum IgG antibodies against periodontal bacteria and serum RF antibody titer (n=2461).</p></sec><sec id="S3"><title>Results</title><p id="P3">Adjusted odds ratios (ORs) (95% CI) summarizing the relationship between the 19 periodontal serum IgGs and RF seropositivity ranged from 0.53 (0.29, 0.97) to 1.27 (0.79, 2.06), and 17 of the 19 observed ORs were < 1.0. The ORs for RF seropositivity among participants with elevated <italic>Prevotella intermedia</italic> [0.53 (0.29, 0.97)] and <italic>Capnocytophaga ochracea</italic> [0.54 (0.31, 0.95)] IgG were statistically significant.</p></sec><sec id="S4"><title>Conclusion</title><p id="P4">We have found elevated periodontal IgGs to be mostly unassociated with RF seropositivity in the nationally representative NHANES III. Elevated antibody levels to <italic>P. intermedia</italic> and <italic>C. ochracea</italic> were associated with lower odds of RF seropositivity.</p></sec></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">101623795</journal-id><journal-id journal-id-type="pubmed-jr-id">42112</journal-id><journal-id journal-id-type="nlm-ta">Arthritis Rheumatol</journal-id><journal-title-group><journal-title>Arthritis & rheumatology (Hoboken, N.J.)</journal-title></journal-title-group><issn pub-type="ppub">2326-5191</issn><issn pub-type="epub">2326-5205</issn></journal-meta><article-meta><article-id pub-id-type="pmid">27110949</article-id><article-id pub-id-type="pmc">5042803</article-id><article-id pub-id-type="doi">10.1002/art.39724</article-id><article-id pub-id-type="manuscript">NIHMS780550</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Association between serum antibodies to periodontal bacteria and rheumatoid factor in NHANES III</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Goh</surname><given-names>Charlene E.</given-names></name><degrees>BDS, MPH</degrees><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Kopp</surname><given-names>Jacob</given-names></name><degrees>MD, MS</degrees><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Papapanou</surname><given-names>Panos N.</given-names></name><degrees>DDS, PhD</degrees><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Molitor</surname><given-names>Jerry A.</given-names></name><degrees>MD, PhD</degrees><xref ref-type="aff" rid="A3">3</xref></contrib><contrib contrib-type="author"><name><surname>Demmer</surname><given-names>Ryan T.</given-names></name><degrees>PhD</degrees><xref ref-type="aff" rid="A1">1</xref></contrib></contrib-group><aff id="A1"><label>1</label>Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA</aff><aff id="A2"><label>2</label>Division of Periodontics, Section of Oral and Diagnostic Sciences, College of Dental Medicine, Columbia University, USA</aff><aff id="A3"><label>3</label>Department of Medicine, University of Minnesota, Minneapolis, MN, USA</aff><author-notes><corresp id="cor1"><bold>Corresponding Author:</bold> Ryan Demmer, PhD, MPH, Assistant Professor, Department of Epidemiology, Columbia University, 722 W. 168<sup>th</sup> St., New York, NY 10032, 212-305-9339, 212-342-4760 (fax), <email>rtd2106@cumc.columbia.edu</email></corresp></author-notes><pub-date pub-type="nihms-submitted"><day>25</day><month>4</month><year>2016</year></pub-date><pub-date pub-type="ppub"><month>10</month><year>2016</year></pub-date><pub-date pub-type="pmc-release"><day>01</day><month>10</month><year>2017</year></pub-date><volume>68</volume><issue>10</issue><fpage>2384</fpage><lpage>2393</lpage><pmc-comment>elocation-id from pubmed: 10.1002/art.39724</pmc-comment>
<abstract><sec id="S1"><title>Objective</title><p id="P1">Alterations in the microbiome, including the periodontal microbiome, may be a risk factor for rheumatoid arthritis (RA). Most studies that have analyzed this association are relatively small, focus primarily on a single periodontal pathogen (<italic>Porphyromonas gingivalis</italic>), and are not population-based. We investigated the association between elevated serum IgG antibodies to 19 periodontal species and the prevalence of rheumatoid factor (RF) in a large nationally representative sample of adults.</p></sec><sec id="S2"><title>Methods</title><p id="P2">The Third National Health and Nutrition Examination Survey is a cross-sectional sample of the non-institutionalized US population (n=33,994). Our study population included all dentate participants ≥60 years, who did not have RA as defined by a modified version of the American College of Rheumatology 1987 criteria, and had complete data for both serum IgG antibodies against periodontal bacteria and serum RF antibody titer (n=2461).</p></sec><sec id="S3"><title>Results</title><p id="P3">Adjusted odds ratios (ORs) (95% CI) summarizing the relationship between the 19 periodontal serum IgGs and RF seropositivity ranged from 0.53 (0.29, 0.97) to 1.27 (0.79, 2.06), and 17 of the 19 observed ORs were < 1.0. The ORs for RF seropositivity among participants with elevated <italic>Prevotella intermedia</italic> [0.53 (0.29, 0.97)] and <italic>Capnocytophaga ochracea</italic> [0.54 (0.31, 0.95)] IgG were statistically significant.</p></sec><sec id="S4"><title>Conclusion</title><p id="P4">We have found elevated periodontal IgGs to be mostly unassociated with RF seropositivity in the nationally representative NHANES III. Elevated antibody levels to <italic>P. intermedia</italic> and <italic>C. ochracea</italic> were associated with lower odds of RF seropositivity.</p></sec></abstract></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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