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Association between serum antibodies to periodontal bacteria and rheumatoid factor in NHANES III

Identifieur interne : 002666 ( Pmc/Corpus ); précédent : 002665; suivant : 002667

Association between serum antibodies to periodontal bacteria and rheumatoid factor in NHANES III

Auteurs : Charlene E. Goh ; Jacob Kopp ; Panos N. Papapanou ; Jerry A. Molitor ; Ryan T. Demmer

Source :

Arthritis & rheumatology (Hoboken, N.J.) [ 2326-5191 ] ; 2016.

RBID : PMC:5042803

Abstract

Objective

Alterations in the microbiome, including the periodontal microbiome, may be a risk factor for rheumatoid arthritis (RA). Most studies that have analyzed this association are relatively small, focus primarily on a single periodontal pathogen (Porphyromonas gingivalis), and are not population-based. We investigated the association between elevated serum IgG antibodies to 19 periodontal species and the prevalence of rheumatoid factor (RF) in a large nationally representative sample of adults.

Methods

The Third National Health and Nutrition Examination Survey is a cross-sectional sample of the non-institutionalized US population (n=33,994). Our study population included all dentate participants ≥60 years, who did not have RA as defined by a modified version of the American College of Rheumatology 1987 criteria, and had complete data for both serum IgG antibodies against periodontal bacteria and serum RF antibody titer (n=2461).

Results

Adjusted odds ratios (ORs) (95% CI) summarizing the relationship between the 19 periodontal serum IgGs and RF seropositivity ranged from 0.53 (0.29, 0.97) to 1.27 (0.79, 2.06), and 17 of the 19 observed ORs were < 1.0. The ORs for RF seropositivity among participants with elevated Prevotella intermedia [0.53 (0.29, 0.97)] and Capnocytophaga ochracea [0.54 (0.31, 0.95)] IgG were statistically significant.

Conclusion

We have found elevated periodontal IgGs to be mostly unassociated with RF seropositivity in the nationally representative NHANES III. Elevated antibody levels to P. intermedia and C. ochracea were associated with lower odds of RF seropositivity.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5042803

DOI: 10.1002/art.39724
PubMed: 27110949
PubMed Central: 5042803

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PMC:5042803

Le document en format XML

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<author><name sortKey="Goh, Charlene E" sort="Goh, Charlene E" uniqKey="Goh C" first="Charlene E." last="Goh">Charlene E. Goh</name>
<affiliation><nlm:aff id="A1">Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Kopp, Jacob" sort="Kopp, Jacob" uniqKey="Kopp J" first="Jacob" last="Kopp">Jacob Kopp</name>
<affiliation><nlm:aff id="A1">Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Papapanou, Panos N" sort="Papapanou, Panos N" uniqKey="Papapanou P" first="Panos N." last="Papapanou">Panos N. Papapanou</name>
<affiliation><nlm:aff id="A2">Division of Periodontics, Section of Oral and Diagnostic Sciences, College of Dental Medicine, Columbia University, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Molitor, Jerry A" sort="Molitor, Jerry A" uniqKey="Molitor J" first="Jerry A." last="Molitor">Jerry A. Molitor</name>
<affiliation><nlm:aff id="A3">Department of Medicine, University of Minnesota, Minneapolis, MN, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Demmer, Ryan T" sort="Demmer, Ryan T" uniqKey="Demmer R" first="Ryan T." last="Demmer">Ryan T. Demmer</name>
<affiliation><nlm:aff id="A1">Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA</nlm:aff>
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<idno type="doi">10.1002/art.39724</idno>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Association between serum antibodies to periodontal bacteria and rheumatoid factor in NHANES III</title>
<author><name sortKey="Goh, Charlene E" sort="Goh, Charlene E" uniqKey="Goh C" first="Charlene E." last="Goh">Charlene E. Goh</name>
<affiliation><nlm:aff id="A1">Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Kopp, Jacob" sort="Kopp, Jacob" uniqKey="Kopp J" first="Jacob" last="Kopp">Jacob Kopp</name>
<affiliation><nlm:aff id="A1">Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Papapanou, Panos N" sort="Papapanou, Panos N" uniqKey="Papapanou P" first="Panos N." last="Papapanou">Panos N. Papapanou</name>
<affiliation><nlm:aff id="A2">Division of Periodontics, Section of Oral and Diagnostic Sciences, College of Dental Medicine, Columbia University, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Molitor, Jerry A" sort="Molitor, Jerry A" uniqKey="Molitor J" first="Jerry A." last="Molitor">Jerry A. Molitor</name>
<affiliation><nlm:aff id="A3">Department of Medicine, University of Minnesota, Minneapolis, MN, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Demmer, Ryan T" sort="Demmer, Ryan T" uniqKey="Demmer R" first="Ryan T." last="Demmer">Ryan T. Demmer</name>
<affiliation><nlm:aff id="A1">Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA</nlm:aff>
</affiliation>
</author>
</analytic>
<series><title level="j">Arthritis & rheumatology (Hoboken, N.J.)</title>
<idno type="ISSN">2326-5191</idno>
<idno type="eISSN">2326-5205</idno>
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<front><div type="abstract" xml:lang="en"><sec id="S1"><title>Objective</title>
<p id="P1">Alterations in the microbiome, including the periodontal microbiome, may be a risk factor for rheumatoid arthritis (RA). Most studies that have analyzed this association are relatively small, focus primarily on a single periodontal pathogen (<italic>Porphyromonas gingivalis</italic>
), and are not population-based. We investigated the association between elevated serum IgG antibodies to 19 periodontal species and the prevalence of rheumatoid factor (RF) in a large nationally representative sample of adults.</p>
</sec>
<sec id="S2"><title>Methods</title>
<p id="P2">The Third National Health and Nutrition Examination Survey is a cross-sectional sample of the non-institutionalized US population (n=33,994). Our study population included all dentate participants ≥60 years, who did not have RA as defined by a modified version of the American College of Rheumatology 1987 criteria, and had complete data for both serum IgG antibodies against periodontal bacteria and serum RF antibody titer (n=2461).</p>
</sec>
<sec id="S3"><title>Results</title>
<p id="P3">Adjusted odds ratios (ORs) (95% CI) summarizing the relationship between the 19 periodontal serum IgGs and RF seropositivity ranged from 0.53 (0.29, 0.97) to 1.27 (0.79, 2.06), and 17 of the 19 observed ORs were < 1.0. The ORs for RF seropositivity among participants with elevated <italic>Prevotella intermedia</italic>
 [0.53 (0.29, 0.97)] and <italic>Capnocytophaga ochracea</italic>
 [0.54 (0.31, 0.95)] IgG were statistically significant.</p>
</sec>
<sec id="S4"><title>Conclusion</title>
<p id="P4">We have found elevated periodontal IgGs to be mostly unassociated with RF seropositivity in the nationally representative NHANES III. Elevated antibody levels to <italic>P. intermedia</italic>
 and <italic>C. ochracea</italic>
 were associated with lower odds of RF seropositivity.</p>
</sec>
</div>
</front>
</TEI>
<pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
  <pmc-dir>properties manuscript</pmc-dir>
  <front><journal-meta><journal-id journal-id-type="nlm-journal-id">101623795</journal-id>
<journal-id journal-id-type="pubmed-jr-id">42112</journal-id>
<journal-id journal-id-type="nlm-ta">Arthritis Rheumatol</journal-id>
<journal-title-group><journal-title>Arthritis & rheumatology (Hoboken, N.J.)</journal-title>
</journal-title-group>
<issn pub-type="ppub">2326-5191</issn>
<issn pub-type="epub">2326-5205</issn>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">27110949</article-id>
<article-id pub-id-type="pmc">5042803</article-id>
<article-id pub-id-type="doi">10.1002/art.39724</article-id>
<article-id pub-id-type="manuscript">NIHMS780550</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Article</subject>
</subj-group>
</article-categories>
<title-group><article-title>Association between serum antibodies to periodontal bacteria and rheumatoid factor in NHANES III</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Goh</surname>
<given-names>Charlene E.</given-names>
</name>
<degrees>BDS, MPH</degrees>
<xref ref-type="aff" rid="A1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Kopp</surname>
<given-names>Jacob</given-names>
</name>
<degrees>MD, MS</degrees>
<xref ref-type="aff" rid="A1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Papapanou</surname>
<given-names>Panos N.</given-names>
</name>
<degrees>DDS, PhD</degrees>
<xref ref-type="aff" rid="A2">2</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Molitor</surname>
<given-names>Jerry A.</given-names>
</name>
<degrees>MD, PhD</degrees>
<xref ref-type="aff" rid="A3">3</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Demmer</surname>
<given-names>Ryan T.</given-names>
</name>
<degrees>PhD</degrees>
<xref ref-type="aff" rid="A1">1</xref>
</contrib>
</contrib-group>
<aff id="A1"><label>1</label>
Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA</aff>
<aff id="A2"><label>2</label>
Division of Periodontics, Section of Oral and Diagnostic Sciences, College of Dental Medicine, Columbia University, USA</aff>
<aff id="A3"><label>3</label>
Department of Medicine, University of Minnesota, Minneapolis, MN, USA</aff>
<author-notes><corresp id="cor1"><bold>Corresponding Author:</bold>
 Ryan Demmer, PhD, MPH, Assistant Professor, Department of Epidemiology, Columbia University, 722 W. 168<sup>th</sup>
 St., New York, NY 10032, 212-305-9339, 212-342-4760 (fax), <email>rtd2106@cumc.columbia.edu</email>
</corresp>
</author-notes>
<pub-date pub-type="nihms-submitted"><day>25</day>
<month>4</month>
<year>2016</year>
</pub-date>
<pub-date pub-type="ppub"><month>10</month>
<year>2016</year>
</pub-date>
<pub-date pub-type="pmc-release"><day>01</day>
<month>10</month>
<year>2017</year>
</pub-date>
<volume>68</volume>
<issue>10</issue>
<fpage>2384</fpage>
<lpage>2393</lpage>
<pmc-comment>elocation-id from pubmed: 10.1002/art.39724</pmc-comment>
      <abstract><sec id="S1"><title>Objective</title>
<p id="P1">Alterations in the microbiome, including the periodontal microbiome, may be a risk factor for rheumatoid arthritis (RA). Most studies that have analyzed this association are relatively small, focus primarily on a single periodontal pathogen (<italic>Porphyromonas gingivalis</italic>
), and are not population-based. We investigated the association between elevated serum IgG antibodies to 19 periodontal species and the prevalence of rheumatoid factor (RF) in a large nationally representative sample of adults.</p>
</sec>
<sec id="S2"><title>Methods</title>
<p id="P2">The Third National Health and Nutrition Examination Survey is a cross-sectional sample of the non-institutionalized US population (n=33,994). Our study population included all dentate participants ≥60 years, who did not have RA as defined by a modified version of the American College of Rheumatology 1987 criteria, and had complete data for both serum IgG antibodies against periodontal bacteria and serum RF antibody titer (n=2461).</p>
</sec>
<sec id="S3"><title>Results</title>
<p id="P3">Adjusted odds ratios (ORs) (95% CI) summarizing the relationship between the 19 periodontal serum IgGs and RF seropositivity ranged from 0.53 (0.29, 0.97) to 1.27 (0.79, 2.06), and 17 of the 19 observed ORs were < 1.0. The ORs for RF seropositivity among participants with elevated <italic>Prevotella intermedia</italic>
 [0.53 (0.29, 0.97)] and <italic>Capnocytophaga ochracea</italic>
 [0.54 (0.31, 0.95)] IgG were statistically significant.</p>
</sec>
<sec id="S4"><title>Conclusion</title>
<p id="P4">We have found elevated periodontal IgGs to be mostly unassociated with RF seropositivity in the nationally representative NHANES III. Elevated antibody levels to <italic>P. intermedia</italic>
 and <italic>C. ochracea</italic>
 were associated with lower odds of RF seropositivity.</p>
</sec>
</abstract>
</article-meta>
</front>
</pmc>
</record>

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Association between serum antibodies to periodontal bacteria and rheumatoid factor in NHANES III

Association between serum antibodies to periodontal bacteria and rheumatoid factor in NHANES III

Source :

Abstract

Links to Exploration step

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Pour générer des pages wiki