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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Salivary proteins associated with hyperglycemia in diabetes: a proteomic analysis</title>
<author><name sortKey="Bencharit, Sompop" sort="Bencharit, Sompop" uniqKey="Bencharit S" first="Sompop" last="Bencharit">Sompop Bencharit</name>
<affiliation><nlm:aff id="A1">Department of Prosthodontics, School of Dentistry, University of North Carolina, Chapel Hill, NC 27599, USA</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="A2">Department of Pharmacology, School of Medicine, University of North Carolina, Chapel Hill, NC 27599, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Baxter, Sarah Schwartz" sort="Baxter, Sarah Schwartz" uniqKey="Baxter S" first="Sarah Schwartz" last="Baxter">Sarah Schwartz Baxter</name>
<affiliation><nlm:aff id="A3">David H. Murdock Research Institute, North Carolina Research Campus, Kannapolis, NC 28081, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Carlson, Jim" sort="Carlson, Jim" uniqKey="Carlson J" first="Jim" last="Carlson">Jim Carlson</name>
<affiliation><nlm:aff id="A3">David H. Murdock Research Institute, North Carolina Research Campus, Kannapolis, NC 28081, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Byrd, Warren C" sort="Byrd, Warren C" uniqKey="Byrd W" first="Warren C." last="Byrd">Warren C. Byrd</name>
<affiliation><nlm:aff id="A1">Department of Prosthodontics, School of Dentistry, University of North Carolina, Chapel Hill, NC 27599, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Mayo, Mary Virginia" sort="Mayo, Mary Virginia" uniqKey="Mayo M" first="Mary Virginia" last="Mayo">Mary Virginia Mayo</name>
<affiliation><nlm:aff id="A1">Department of Prosthodontics, School of Dentistry, University of North Carolina, Chapel Hill, NC 27599, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Border, Michael B" sort="Border, Michael B" uniqKey="Border M" first="Michael B." last="Border">Michael B. Border</name>
<affiliation><nlm:aff id="A1">Department of Prosthodontics, School of Dentistry, University of North Carolina, Chapel Hill, NC 27599, USA</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="A4">College of Dentistry, Ohio State University, Columbus, OH 43210, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Kohltfarber, Heidi" sort="Kohltfarber, Heidi" uniqKey="Kohltfarber H" first="Heidi" last="Kohltfarber">Heidi Kohltfarber</name>
<affiliation><nlm:aff id="A5">Department of Diagnostic Science and General Dentistry, School of Dentistry, University of North Carolina, Chapel Hill, NC 27599, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Urrutia, Eugene" sort="Urrutia, Eugene" uniqKey="Urrutia E" first="Eugene" last="Urrutia">Eugene Urrutia</name>
<affiliation><nlm:aff id="A6">Department of Biostatistics, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC 27599, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Howard Williams, Escher L" sort="Howard Williams, Escher L" uniqKey="Howard Williams E" first="Escher L." last="Howard-Williams">Escher L. Howard-Williams</name>
<affiliation><nlm:aff id="A7">Department of Medicine, School of Medicine, University of North Carolina, Chapel Hill, NC 27599, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Offenbacher, Steven" sort="Offenbacher, Steven" uniqKey="Offenbacher S" first="Steven" last="Offenbacher">Steven Offenbacher</name>
<affiliation><nlm:aff id="A8">Department of Periodontology, School of Dentistry, University of North Carolina, Chapel Hill, NC 27599, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Wu, Michael C" sort="Wu, Michael C" uniqKey="Wu M" first="Michael C." last="Wu">Michael C. Wu</name>
<affiliation><nlm:aff id="A6">Department of Biostatistics, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC 27599, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Buse, John B" sort="Buse, John B" uniqKey="Buse J" first="John B." last="Buse">John B. Buse</name>
<affiliation><nlm:aff id="A9">Division of Endocrinology, Department of Medicine, School of Medicine, University of North Carolina, Chapel Hill, NC 27599, USA</nlm:aff>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">24056972</idno>
<idno type="pmc">3888809</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3888809</idno>
<idno type="RBID">PMC:3888809</idno>
<idno type="doi">10.1039/c3mb70196d</idno>
<date when="2013">2013</date>
<idno type="wicri:Area/Pmc/Corpus">002646</idno>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Salivary proteins associated with hyperglycemia in diabetes: a proteomic analysis</title>
<author><name sortKey="Bencharit, Sompop" sort="Bencharit, Sompop" uniqKey="Bencharit S" first="Sompop" last="Bencharit">Sompop Bencharit</name>
<affiliation><nlm:aff id="A1">Department of Prosthodontics, School of Dentistry, University of North Carolina, Chapel Hill, NC 27599, USA</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="A2">Department of Pharmacology, School of Medicine, University of North Carolina, Chapel Hill, NC 27599, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Baxter, Sarah Schwartz" sort="Baxter, Sarah Schwartz" uniqKey="Baxter S" first="Sarah Schwartz" last="Baxter">Sarah Schwartz Baxter</name>
<affiliation><nlm:aff id="A3">David H. Murdock Research Institute, North Carolina Research Campus, Kannapolis, NC 28081, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Carlson, Jim" sort="Carlson, Jim" uniqKey="Carlson J" first="Jim" last="Carlson">Jim Carlson</name>
<affiliation><nlm:aff id="A3">David H. Murdock Research Institute, North Carolina Research Campus, Kannapolis, NC 28081, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Byrd, Warren C" sort="Byrd, Warren C" uniqKey="Byrd W" first="Warren C." last="Byrd">Warren C. Byrd</name>
<affiliation><nlm:aff id="A1">Department of Prosthodontics, School of Dentistry, University of North Carolina, Chapel Hill, NC 27599, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Mayo, Mary Virginia" sort="Mayo, Mary Virginia" uniqKey="Mayo M" first="Mary Virginia" last="Mayo">Mary Virginia Mayo</name>
<affiliation><nlm:aff id="A1">Department of Prosthodontics, School of Dentistry, University of North Carolina, Chapel Hill, NC 27599, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Border, Michael B" sort="Border, Michael B" uniqKey="Border M" first="Michael B." last="Border">Michael B. Border</name>
<affiliation><nlm:aff id="A1">Department of Prosthodontics, School of Dentistry, University of North Carolina, Chapel Hill, NC 27599, USA</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="A4">College of Dentistry, Ohio State University, Columbus, OH 43210, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Kohltfarber, Heidi" sort="Kohltfarber, Heidi" uniqKey="Kohltfarber H" first="Heidi" last="Kohltfarber">Heidi Kohltfarber</name>
<affiliation><nlm:aff id="A5">Department of Diagnostic Science and General Dentistry, School of Dentistry, University of North Carolina, Chapel Hill, NC 27599, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Urrutia, Eugene" sort="Urrutia, Eugene" uniqKey="Urrutia E" first="Eugene" last="Urrutia">Eugene Urrutia</name>
<affiliation><nlm:aff id="A6">Department of Biostatistics, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC 27599, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Howard Williams, Escher L" sort="Howard Williams, Escher L" uniqKey="Howard Williams E" first="Escher L." last="Howard-Williams">Escher L. Howard-Williams</name>
<affiliation><nlm:aff id="A7">Department of Medicine, School of Medicine, University of North Carolina, Chapel Hill, NC 27599, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Offenbacher, Steven" sort="Offenbacher, Steven" uniqKey="Offenbacher S" first="Steven" last="Offenbacher">Steven Offenbacher</name>
<affiliation><nlm:aff id="A8">Department of Periodontology, School of Dentistry, University of North Carolina, Chapel Hill, NC 27599, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Wu, Michael C" sort="Wu, Michael C" uniqKey="Wu M" first="Michael C." last="Wu">Michael C. Wu</name>
<affiliation><nlm:aff id="A6">Department of Biostatistics, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC 27599, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Buse, John B" sort="Buse, John B" uniqKey="Buse J" first="John B." last="Buse">John B. Buse</name>
<affiliation><nlm:aff id="A9">Division of Endocrinology, Department of Medicine, School of Medicine, University of North Carolina, Chapel Hill, NC 27599, USA</nlm:aff>
</affiliation>
</author>
</analytic>
<series><title level="j">Molecular bioSystems</title>
<idno type="ISSN">1742-206X</idno>
<idno type="eISSN">1742-2051</idno>
<imprint><date when="2013">2013</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p id="P1">Effective monitoring of glucose levels is necessary for patients to achieve greater control over their diabetes. However, only about a quarter of subjects with diabetes who requires close serum glucose monitoring, regularly check their serum glucose daily. One of the potential barriers to patient compliance is the blood sampling requirement. Saliva and its protein contents can be altered in subjects with diabetes, possibly due to changes in glycemic control. We propose here that salivary proteomes of subjects with diabetes may be different based on their glycemic control as reflected in A1C levels. A total of 153 subjects with type 1 or 2 diabetes were recruited. Subjects in each type of diabetes were divided into 5 groups based on their A1C levels; <7, 7–8, 8–9, 9–10, >10. To examine the global proteomic changes associated with A1C, the proteomic profiling of pooled saliva samples from each group was created using label-free quantitative proteomics. Similar proteomic analysis for individual subjects (N=4, for each group) were then applied to examine proteins that may be less abundant in pooled samples. Principle component analysis (PCA) and cluster analysis (p<0.01 and p<0.001) were used to define the proteomic differences. We, therefore, defined the salivary proteomic changes associated with A1C changes. This study demonstrates that differences exist between salivary proteomic profiles in subjects with diabetes based on the A1C levels.</p>
</div>
</front>
</TEI>
<pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">101251620</journal-id>
<journal-id journal-id-type="pubmed-jr-id">33015</journal-id>
<journal-id journal-id-type="nlm-ta">Mol Biosyst</journal-id>
<journal-id journal-id-type="iso-abbrev">Mol Biosyst</journal-id>
<journal-title-group><journal-title>Molecular bioSystems</journal-title>
</journal-title-group>
<issn pub-type="ppub">1742-206X</issn>
<issn pub-type="epub">1742-2051</issn>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">24056972</article-id>
<article-id pub-id-type="pmc">3888809</article-id>
<article-id pub-id-type="doi">10.1039/c3mb70196d</article-id>
<article-id pub-id-type="manuscript">NIHMS521242</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Article</subject>
</subj-group>
</article-categories>
<title-group><article-title>Salivary proteins associated with hyperglycemia in diabetes: a proteomic analysis</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Bencharit</surname>
<given-names>Sompop</given-names>
</name>
<xref ref-type="aff" rid="A1">1</xref>
<xref ref-type="aff" rid="A2">2</xref>
<xref rid="FN1" ref-type="author-notes">*</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Baxter</surname>
<given-names>Sarah Schwartz</given-names>
</name>
<xref ref-type="aff" rid="A3">3</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Carlson</surname>
<given-names>Jim</given-names>
</name>
<xref ref-type="aff" rid="A3">3</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Byrd</surname>
<given-names>Warren C.</given-names>
</name>
<xref ref-type="aff" rid="A1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Mayo</surname>
<given-names>Mary Virginia</given-names>
</name>
<xref ref-type="aff" rid="A1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Border</surname>
<given-names>Michael B.</given-names>
</name>
<xref ref-type="aff" rid="A1">1</xref>
<xref ref-type="aff" rid="A4">4</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Kohltfarber</surname>
<given-names>Heidi</given-names>
</name>
<xref ref-type="aff" rid="A5">5</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Urrutia</surname>
<given-names>Eugene</given-names>
</name>
<xref ref-type="aff" rid="A6">6</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Howard-Williams</surname>
<given-names>Escher L.</given-names>
</name>
<xref ref-type="aff" rid="A7">7</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Offenbacher</surname>
<given-names>Steven</given-names>
</name>
<xref ref-type="aff" rid="A8">8</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Wu</surname>
<given-names>Michael C.</given-names>
</name>
<xref ref-type="aff" rid="A6">6</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Buse</surname>
<given-names>John B.</given-names>
</name>
<xref ref-type="aff" rid="A9">9</xref>
</contrib>
</contrib-group>
<aff id="A1"><label>1</label>
Department of Prosthodontics, School of Dentistry, University of North Carolina, Chapel Hill, NC 27599, USA</aff>
<aff id="A2"><label>2</label>
Department of Pharmacology, School of Medicine, University of North Carolina, Chapel Hill, NC 27599, USA</aff>
<aff id="A3"><label>3</label>
David H. Murdock Research Institute, North Carolina Research Campus, Kannapolis, NC 28081, USA</aff>
<aff id="A4"><label>4</label>
College of Dentistry, Ohio State University, Columbus, OH 43210, USA</aff>
<aff id="A5"><label>5</label>
Department of Diagnostic Science and General Dentistry, School of Dentistry, University of North Carolina, Chapel Hill, NC 27599, USA</aff>
<aff id="A6"><label>6</label>
Department of Biostatistics, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC 27599, USA</aff>
<aff id="A7"><label>7</label>
Department of Medicine, School of Medicine, University of North Carolina, Chapel Hill, NC 27599, USA</aff>
<aff id="A8"><label>8</label>
Department of Periodontology, School of Dentistry, University of North Carolina, Chapel Hill, NC 27599, USA</aff>
<aff id="A9"><label>9</label>
Division of Endocrinology, Department of Medicine, School of Medicine, University of North Carolina, Chapel Hill, NC 27599, USA</aff>
<author-notes><corresp id="FN1"><label>*</label>
Address correspondence to: Sompop Bencharit, DDS, MS, PhD, FACP, Department of Prosthodontics, School of Dentistry, Department of Pharmacology, School of Medicine, CB#7450, Chapel Hill, NC 27599-7450, Tel: 919-843-8734, Fax: 919-966-3821, <email>Sompop_Bencharit@unc.edu</email>
</corresp>
</author-notes>
<pub-date pub-type="nihms-submitted"><day>17</day>
<month>12</month>
<year>2013</year>
</pub-date>
<pub-date pub-type="ppub"><month>11</month>
<year>2013</year>
</pub-date>
<pub-date pub-type="pmc-release"><day>01</day>
<month>11</month>
<year>2014</year>
</pub-date>
<volume>9</volume>
<issue>11</issue>
<fpage>2785</fpage>
<lpage>2797</lpage>
<pmc-comment>elocation-id from pubmed: 10.1039/c3mb70196d</pmc-comment>
<abstract><p id="P1">Effective monitoring of glucose levels is necessary for patients to achieve greater control over their diabetes. However, only about a quarter of subjects with diabetes who requires close serum glucose monitoring, regularly check their serum glucose daily. One of the potential barriers to patient compliance is the blood sampling requirement. Saliva and its protein contents can be altered in subjects with diabetes, possibly due to changes in glycemic control. We propose here that salivary proteomes of subjects with diabetes may be different based on their glycemic control as reflected in A1C levels. A total of 153 subjects with type 1 or 2 diabetes were recruited. Subjects in each type of diabetes were divided into 5 groups based on their A1C levels; <7, 7–8, 8–9, 9–10, >10. To examine the global proteomic changes associated with A1C, the proteomic profiling of pooled saliva samples from each group was created using label-free quantitative proteomics. Similar proteomic analysis for individual subjects (N=4, for each group) were then applied to examine proteins that may be less abundant in pooled samples. Principle component analysis (PCA) and cluster analysis (p<0.01 and p<0.001) were used to define the proteomic differences. We, therefore, defined the salivary proteomic changes associated with A1C changes. This study demonstrates that differences exist between salivary proteomic profiles in subjects with diabetes based on the A1C levels.</p>
</abstract>
<kwd-group><kwd>A1C</kwd>
<kwd>Diabetes</kwd>
<kwd>Mass Spectrometry</kwd>
<kwd>Saliva</kwd>
<kwd>Proteome</kwd>
</kwd-group>
</article-meta>
</front>
</pmc>
</record>
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