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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Drug Release from Calcium Sulfate-Based Composites</title><author><name sortKey="Orellana, Bryan R" sort="Orellana, Bryan R" uniqKey="Orellana B" first="Bryan R." last="Orellana">Bryan R. Orellana</name><affiliation><nlm:aff id="A1">Department of Biomedical Engineering, University of Kentucky, Lexington, KY, USA</nlm:aff></affiliation></author><author><name sortKey="Hilt, J Zach" sort="Hilt, J Zach" uniqKey="Hilt J" first="J. Zach" last="Hilt">J. Zach Hilt</name><affiliation><nlm:aff id="A2">Department of Chemical and Materials Engineering, University of Kentucky, Lexington, KY, USA</nlm:aff></affiliation></author><author><name sortKey="Puleo, David A" sort="Puleo, David A" uniqKey="Puleo D" first="David A." last="Puleo">David A. Puleo</name><affiliation><nlm:aff id="A1">Department of Biomedical Engineering, University of Kentucky, Lexington, KY, USA</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">24788686</idno><idno type="pmc">4302276</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4302276</idno><idno type="RBID">PMC:4302276</idno><idno type="doi">10.1002/jbm.b.33181</idno><date when="2014">2014</date><idno type="wicri:Area/Pmc/Corpus">002643</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002643</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Drug Release from Calcium Sulfate-Based Composites</title><author><name sortKey="Orellana, Bryan R" sort="Orellana, Bryan R" uniqKey="Orellana B" first="Bryan R." last="Orellana">Bryan R. Orellana</name><affiliation><nlm:aff id="A1">Department of Biomedical Engineering, University of Kentucky, Lexington, KY, USA</nlm:aff></affiliation></author><author><name sortKey="Hilt, J Zach" sort="Hilt, J Zach" uniqKey="Hilt J" first="J. Zach" last="Hilt">J. Zach Hilt</name><affiliation><nlm:aff id="A2">Department of Chemical and Materials Engineering, University of Kentucky, Lexington, KY, USA</nlm:aff></affiliation></author><author><name sortKey="Puleo, David A" sort="Puleo, David A" uniqKey="Puleo D" first="David A." last="Puleo">David A. Puleo</name><affiliation><nlm:aff id="A1">Department of Biomedical Engineering, University of Kentucky, Lexington, KY, USA</nlm:aff></affiliation></author></analytic><series><title level="j">Journal of biomedical materials research. Part B, Applied biomaterials</title><idno type="ISSN">1552-4973</idno><idno type="eISSN">1552-4981</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P1">To help reduce the need for autografts, calcium sulfate-based bone graft substitutes are being developed to provide a stable platform to aid augmentation while having the ability to release a broad range of bioactive agents. Calcium sulfate (CS) has an excellent reputation as a biocompatible and osteoconductive substance, but addition of bioactive agents may further enhance these properties. Samples were produced with either directly loaded small, hydrophobic molecule (<italic>i.e.</italic>, simvastatin), directly loaded hydrophilic protein (<italic>i.e.</italic>, lysozyme), or 1 and 10 wt% of H6 poly(β-amino ester) (PBAE) particles containing protein. Whereas sustained release of directly loaded simvastatin was achieved, direct loading of small amounts of lysozyme resulted in highly variable release. Direct loading of a larger amount of protein generated a large burst, 65% of total loading, followed by sustained release of protein. Release of lysozyme from 1 wt% PBAE particles embedded into CS was more controllable than when directly loaded, and for 10 wt% of protein-loaded PBAE particles, a higher burst was followed by sustained release, comparable to the results for the high direct loading. Compression testing determined that incorporation of directly loaded drug or drug-loaded PBAE particles weakened CS. In particular, PBAE particles had a significant effect on the strength of the composites, with a 25% and 80% decrease in strength for 1 wt% and 10 wt% particle loadings, respectively. CS-based composites demonstrated the ability to sustainably release both macromolecules and small molecules, supporting the potential for these materials to release a range of therapeutic agents.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">101234238</journal-id><journal-id journal-id-type="pubmed-jr-id">32208</journal-id><journal-id journal-id-type="nlm-ta">J Biomed Mater Res B Appl Biomater</journal-id><journal-id journal-id-type="iso-abbrev">J. Biomed. Mater. Res. Part B Appl. Biomater.</journal-id><journal-title-group><journal-title>Journal of biomedical materials research. Part B, Applied biomaterials</journal-title></journal-title-group><issn pub-type="ppub">1552-4973</issn><issn pub-type="epub">1552-4981</issn></journal-meta><article-meta><article-id pub-id-type="pmid">24788686</article-id><article-id pub-id-type="pmc">4302276</article-id><article-id pub-id-type="doi">10.1002/jbm.b.33181</article-id><article-id pub-id-type="manuscript">NIHMS656097</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Drug Release from Calcium Sulfate-Based Composites</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Orellana</surname><given-names>Bryan R.</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Hilt</surname><given-names>J. Zach</given-names></name><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Puleo</surname><given-names>David A.</given-names></name><xref ref-type="aff" rid="A1">1</xref><xref ref-type="corresp" rid="cor1">*</xref></contrib></contrib-group><aff id="A1"><label>1</label>Department of Biomedical Engineering, University of Kentucky, Lexington, KY, USA</aff><aff id="A2"><label>2</label>Department of Chemical and Materials Engineering, University of Kentucky, Lexington, KY, USA</aff><author-notes><corresp id="cor1"><bold>Corresponding author</bold>: David Puleo, Ph.D., 209 Wenner-Gren Lab, Department of Biomedical Engineering, University of Kentucky, Lexington, KY 40506-0070, USA, Tel: +1-859-257-2405, Fax: +1-859-257-1856, <email>puleo@uky.edu</email></corresp></author-notes><pub-date pub-type="nihms-submitted"><day>16</day><month>1</month><year>2015</year></pub-date><pub-date pub-type="epub"><day>30</day><month>4</month><year>2014</year></pub-date><pub-date pub-type="ppub"><month>1</month><year>2015</year></pub-date><pub-date pub-type="pmc-release"><day>01</day><month>1</month><year>2016</year></pub-date><volume>103</volume><issue>1</issue><fpage>135</fpage><lpage>142</lpage><pmc-comment>elocation-id from pubmed: 10.1002/jbm.b.33181</pmc-comment>
<abstract><p id="P1">To help reduce the need for autografts, calcium sulfate-based bone graft substitutes are being developed to provide a stable platform to aid augmentation while having the ability to release a broad range of bioactive agents. Calcium sulfate (CS) has an excellent reputation as a biocompatible and osteoconductive substance, but addition of bioactive agents may further enhance these properties. Samples were produced with either directly loaded small, hydrophobic molecule (<italic>i.e.</italic>, simvastatin), directly loaded hydrophilic protein (<italic>i.e.</italic>, lysozyme), or 1 and 10 wt% of H6 poly(β-amino ester) (PBAE) particles containing protein. Whereas sustained release of directly loaded simvastatin was achieved, direct loading of small amounts of lysozyme resulted in highly variable release. Direct loading of a larger amount of protein generated a large burst, 65% of total loading, followed by sustained release of protein. Release of lysozyme from 1 wt% PBAE particles embedded into CS was more controllable than when directly loaded, and for 10 wt% of protein-loaded PBAE particles, a higher burst was followed by sustained release, comparable to the results for the high direct loading. Compression testing determined that incorporation of directly loaded drug or drug-loaded PBAE particles weakened CS. In particular, PBAE particles had a significant effect on the strength of the composites, with a 25% and 80% decrease in strength for 1 wt% and 10 wt% particle loadings, respectively. CS-based composites demonstrated the ability to sustainably release both macromolecules and small molecules, supporting the potential for these materials to release a range of therapeutic agents.</p></abstract><kwd-group><kwd>Calcium sulfate</kwd><kwd>drug delivery</kwd><kwd>synthetic bone graft</kwd><kwd>simvastatin</kwd><kwd>lysozyme</kwd></kwd-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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