Periodontal Disease, Tooth Loss and Incident Rheumatoid Arthritis: Results from the First National Health and Nutrition Examination Survey and its Epidemiologic Follow-up Study
Identifieur interne : 002615 ( Pmc/Corpus ); précédent : 002614; suivant : 002616Periodontal Disease, Tooth Loss and Incident Rheumatoid Arthritis: Results from the First National Health and Nutrition Examination Survey and its Epidemiologic Follow-up Study
Auteurs : Ryan T. Demmer ; Jerry A. Molitor ; David R. Jacobs ; Bryan S. MichalowiczSource :
- Journal of Clinical Periodontology [ 0303-6979 ] ; 2011.
Abstract
Infection may be a rheumatoid arthritis (RA) risk factor. We examined whether signs of periodontal infection were associated with RA development in NHANES I & NHEFS.
In 1971–1974, 9,702 men and women aged 25–74 were enrolled and surveyed longitudinally (1982,1986,1987,1992). Periodontal infection was defined by baseline tooth loss or clinical evidence of periodontal disease. Baseline(n=138) and incident(n=433) RA cases were defined via self-report physician diagnosis, joint pain/swelling, ICD-9 codes (714.0–714.9), death certificates, and/or RA hospitalization.
Adjusted odds ratios (ORs)[95%CI] for prevalent RA in gingivitis and periodontitis (vs. healthy) were 1.09[0.57,2.10] and 1.85[0.95,3.63]; incident RA ORs were 1.32[0.85,2.06] and 1.00[0.68,1.48]. The ORs for prevalent RA among participants missing 5–8, 9–14, 15–31 or 32 teeth (vs. 0–4 teeth) were 1.74[1.03,2.95], 1.82[0.81,4.10], 1.45[0.62,3.41] and 1.30[0.48,3.53]; ORs for incident RA were 1.12[0.77,1.64], 1.67[1.12,2.48], 1.40[0.85,2.33] and 1.22[0.75,2.00]. Dose-responsiveness was enhanced among never-smokers. The rate of death or loss-to-follow-up after 1982 was 2–4 fold higher among participants with periodontitis or missing ≥9 teeth (vs. healthy participants).
Although participants with periodontal disease or≥5 missing teeth experienced higher odds of prevalent/incident RA, most ORs were nonstatistically significant and lacked dose-responsiveness. Differential RA ascertainment bias complicated the interpretation of these data.
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DOI: 10.1111/j.1600-051X.2011.01776.x
PubMed: 22092471
PubMed Central: 3403745
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Jacobs</name><affiliation><nlm:aff id="A3">Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, MN</nlm:aff></affiliation><affiliation><nlm:aff id="A4">Department of Nutrition, University of Oslo, Oslo, Norway</nlm:aff></affiliation></author><author><name sortKey="Michalowicz, Bryan S" sort="Michalowicz, Bryan S" uniqKey="Michalowicz B" first="Bryan S." last="Michalowicz">Bryan S. Michalowicz</name><affiliation><nlm:aff id="A5">Department of Developmental and Surgical Sciences, University of Minnesota, Minneapolis, MN</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">22092471</idno><idno type="pmc">3403745</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3403745</idno><idno type="RBID">PMC:3403745</idno><idno type="doi">10.1111/j.1600-051X.2011.01776.x</idno><date when="2011">2011</date><idno type="wicri:Area/Pmc/Corpus">002615</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002615</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Periodontal Disease, Tooth Loss and Incident Rheumatoid Arthritis: Results from the First National Health and Nutrition Examination Survey and its Epidemiologic Follow-up Study</title><author><name sortKey="Demmer, Ryan T" sort="Demmer, Ryan T" uniqKey="Demmer R" first="Ryan T." last="Demmer">Ryan T. Demmer</name><affiliation><nlm:aff id="A1">Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY</nlm:aff></affiliation></author><author><name sortKey="Molitor, Jerry A" sort="Molitor, Jerry A" uniqKey="Molitor J" first="Jerry A." last="Molitor">Jerry A. Molitor</name><affiliation><nlm:aff id="A2">Department of Medicine, University of Minnesota, Minneapolis, MN</nlm:aff></affiliation></author><author><name sortKey="Jacobs, David R" sort="Jacobs, David R" uniqKey="Jacobs D" first="David R." last="Jacobs">David R. Jacobs</name><affiliation><nlm:aff id="A3">Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, MN</nlm:aff></affiliation><affiliation><nlm:aff id="A4">Department of Nutrition, University of Oslo, Oslo, Norway</nlm:aff></affiliation></author><author><name sortKey="Michalowicz, Bryan S" sort="Michalowicz, Bryan S" uniqKey="Michalowicz B" first="Bryan S." last="Michalowicz">Bryan S. Michalowicz</name><affiliation><nlm:aff id="A5">Department of Developmental and Surgical Sciences, University of Minnesota, Minneapolis, MN</nlm:aff></affiliation></author></analytic><series><title level="j">Journal of Clinical Periodontology</title><idno type="ISSN">0303-6979</idno><idno type="eISSN">1600-051X</idno><imprint><date when="2011">2011</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="S1"><title>Aims</title><p id="P1">Infection may be a rheumatoid arthritis (RA) risk factor. We examined whether signs of periodontal infection were associated with RA development in NHANES I & NHEFS.</p></sec><sec id="S2"><title>Materials and Methods</title><p id="P2">In 1971–1974, 9,702 men and women aged 25–74 were enrolled and surveyed longitudinally (1982,1986,1987,1992). Periodontal infection was defined by baseline tooth loss or clinical evidence of periodontal disease. Baseline(n=138) and incident(n=433) RA cases were defined via self-report physician diagnosis, joint pain/swelling, ICD-9 codes (714.0–714.9), death certificates, and/or RA hospitalization.</p></sec><sec id="S3"><title>Results</title><p id="P3">Adjusted odds ratios (ORs)[95%CI] for prevalent RA in gingivitis and periodontitis (vs. healthy) were 1.09[0.57,2.10] and 1.85[0.95,3.63]; incident RA ORs were 1.32[0.85,2.06] and 1.00[0.68,1.48]. The ORs for prevalent RA among participants missing 5–8, 9–14, 15–31 or 32 teeth (vs. 0–4 teeth) were 1.74[1.03,2.95], 1.82[0.81,4.10], 1.45[0.62,3.41] and 1.30[0.48,3.53]; ORs for incident RA were 1.12[0.77,1.64], 1.67[1.12,2.48], 1.40[0.85,2.33] and 1.22[0.75,2.00]. Dose-responsiveness was enhanced among never-smokers. The rate of death or loss-to-follow-up after 1982 was 2–4 fold higher among participants with periodontitis or missing ≥9 teeth (vs. healthy participants).</p></sec><sec id="S4"><title>Conclusions</title><p id="P4">Although participants with periodontal disease or≥5 missing teeth experienced higher odds of prevalent/incident RA, most ORs were nonstatistically significant and lacked dose-responsiveness. Differential RA ascertainment bias complicated the interpretation of these data.</p></sec></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">0425123</journal-id><journal-id journal-id-type="pubmed-jr-id">4645</journal-id><journal-id journal-id-type="nlm-ta">J Clin Periodontol</journal-id><journal-id journal-id-type="iso-abbrev">J. Clin. Periodontol.</journal-id><journal-title-group><journal-title>Journal of Clinical Periodontology</journal-title></journal-title-group><issn pub-type="ppub">0303-6979</issn><issn pub-type="epub">1600-051X</issn></journal-meta><article-meta><article-id pub-id-type="pmid">22092471</article-id><article-id pub-id-type="pmc">3403745</article-id><article-id pub-id-type="doi">10.1111/j.1600-051X.2011.01776.x</article-id><article-id pub-id-type="manuscript">NIHMS390483</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Periodontal Disease, Tooth Loss and Incident Rheumatoid Arthritis: Results from the First National Health and Nutrition Examination Survey and its Epidemiologic Follow-up Study</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Demmer</surname><given-names>Ryan T.</given-names></name><degrees>PhD, MPH</degrees><xref ref-type="aff" rid="A1">a</xref></contrib><contrib contrib-type="author"><name><surname>Molitor</surname><given-names>Jerry A.</given-names></name><degrees>MD, PhD</degrees><xref ref-type="aff" rid="A2">b</xref></contrib><contrib contrib-type="author"><name><surname>Jacobs</surname><given-names>David R.</given-names><suffix>Jr.</suffix></name><degrees>PhD</degrees><xref ref-type="aff" rid="A3">c</xref><xref ref-type="aff" rid="A4">d</xref></contrib><contrib contrib-type="author"><name><surname>Michalowicz</surname><given-names>Bryan S.</given-names></name><degrees>DDS</degrees><xref ref-type="aff" rid="A5">e</xref></contrib></contrib-group><aff id="A1"><label>a</label>Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY</aff><aff id="A2"><label>b</label>Department of Medicine, University of Minnesota, Minneapolis, MN</aff><aff id="A3"><label>c</label>Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, MN</aff><aff id="A4"><label>d</label>Department of Nutrition, University of Oslo, Oslo, Norway</aff><aff id="A5"><label>e</label>Department of Developmental and Surgical Sciences, University of Minnesota, Minneapolis, MN</aff><author-notes><corresp id="FN1">Address for Correspondence: Ryan Demmer, PhD, 722 W. 168<sup>th</sup>, 7<sup>th</sup> Floor, New York, NY 10040, <email>rtd2106@columbia.edu</email></corresp></author-notes><pub-date pub-type="nihms-submitted"><day>11</day><month>7</month><year>2012</year></pub-date><pub-date pub-type="epub"><day>13</day><month>9</month><year>2011</year></pub-date><pub-date pub-type="ppub"><month>11</month><year>2011</year></pub-date><pub-date pub-type="pmc-release"><day>24</day><month>7</month><year>2012</year></pub-date><volume>38</volume><issue>11</issue><fpage>998</fpage><lpage>1006</lpage><abstract><sec id="S1"><title>Aims</title><p id="P1">Infection may be a rheumatoid arthritis (RA) risk factor. We examined whether signs of periodontal infection were associated with RA development in NHANES I & NHEFS.</p></sec><sec id="S2"><title>Materials and Methods</title><p id="P2">In 1971–1974, 9,702 men and women aged 25–74 were enrolled and surveyed longitudinally (1982,1986,1987,1992). Periodontal infection was defined by baseline tooth loss or clinical evidence of periodontal disease. Baseline(n=138) and incident(n=433) RA cases were defined via self-report physician diagnosis, joint pain/swelling, ICD-9 codes (714.0–714.9), death certificates, and/or RA hospitalization.</p></sec><sec id="S3"><title>Results</title><p id="P3">Adjusted odds ratios (ORs)[95%CI] for prevalent RA in gingivitis and periodontitis (vs. healthy) were 1.09[0.57,2.10] and 1.85[0.95,3.63]; incident RA ORs were 1.32[0.85,2.06] and 1.00[0.68,1.48]. The ORs for prevalent RA among participants missing 5–8, 9–14, 15–31 or 32 teeth (vs. 0–4 teeth) were 1.74[1.03,2.95], 1.82[0.81,4.10], 1.45[0.62,3.41] and 1.30[0.48,3.53]; ORs for incident RA were 1.12[0.77,1.64], 1.67[1.12,2.48], 1.40[0.85,2.33] and 1.22[0.75,2.00]. Dose-responsiveness was enhanced among never-smokers. The rate of death or loss-to-follow-up after 1982 was 2–4 fold higher among participants with periodontitis or missing ≥9 teeth (vs. healthy participants).</p></sec><sec id="S4"><title>Conclusions</title><p id="P4">Although participants with periodontal disease or≥5 missing teeth experienced higher odds of prevalent/incident RA, most ORs were nonstatistically significant and lacked dose-responsiveness. Differential RA ascertainment bias complicated the interpretation of these data.</p></sec></abstract><kwd-group><kwd>Rheumatoid Arthritis</kwd><kwd>Periodontal</kwd><kwd>Infections</kwd><kwd>Cohort Studies</kwd><kwd>Bias</kwd></kwd-group><funding-group><award-group><funding-source country="United States">National Institute of Dental and Craniofacial Research : NIDCR</funding-source><award-id>R00 DE018739 || DE</award-id></award-group></funding-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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