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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Review of the Complications Associated with Treatment of Oropharyngeal Cancer: A Guide to the Dental Practitioner</title><author><name sortKey="Turner, Lena" sort="Turner, Lena" uniqKey="Turner L" first="Lena" last="Turner">Lena Turner</name><affiliation><nlm:aff id="A1">Department of Oral Medicine, School of Dental Medicine University of Pennsylvania, Philadelphia PA</nlm:aff></affiliation></author><author><name sortKey="Mupparapu, Muralidhar" sort="Mupparapu, Muralidhar" uniqKey="Mupparapu M" first="Muralidhar" last="Mupparapu">Muralidhar Mupparapu</name><affiliation><nlm:aff id="A1">Department of Oral Medicine, School of Dental Medicine University of Pennsylvania, Philadelphia PA</nlm:aff></affiliation></author><author><name sortKey="Akintoye, Sunday O" sort="Akintoye, Sunday O" uniqKey="Akintoye S" first="Sunday O" last="Akintoye">Sunday O. Akintoye</name><affiliation><nlm:aff id="A1">Department of Oral Medicine, School of Dental Medicine University of Pennsylvania, Philadelphia PA</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">23444208</idno><idno type="pmc">3773981</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3773981</idno><idno type="RBID">PMC:3773981</idno><idno type="doi">10.3290/j.qi.a29050</idno><date when="2013">2013</date><idno type="wicri:Area/Pmc/Corpus">002591</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002591</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Review of the Complications Associated with Treatment of Oropharyngeal Cancer: A Guide to the Dental Practitioner</title><author><name sortKey="Turner, Lena" sort="Turner, Lena" uniqKey="Turner L" first="Lena" last="Turner">Lena Turner</name><affiliation><nlm:aff id="A1">Department of Oral Medicine, School of Dental Medicine University of Pennsylvania, Philadelphia PA</nlm:aff></affiliation></author><author><name sortKey="Mupparapu, Muralidhar" sort="Mupparapu, Muralidhar" uniqKey="Mupparapu M" first="Muralidhar" last="Mupparapu">Muralidhar Mupparapu</name><affiliation><nlm:aff id="A1">Department of Oral Medicine, School of Dental Medicine University of Pennsylvania, Philadelphia PA</nlm:aff></affiliation></author><author><name sortKey="Akintoye, Sunday O" sort="Akintoye, Sunday O" uniqKey="Akintoye S" first="Sunday O" last="Akintoye">Sunday O. Akintoye</name><affiliation><nlm:aff id="A1">Department of Oral Medicine, School of Dental Medicine University of Pennsylvania, Philadelphia PA</nlm:aff></affiliation></author></analytic><series><title level="j">Quintessence international (Berlin, Germany : 1985)</title><idno type="ISSN">0033-6572</idno><idno type="eISSN">1936-7163</idno><imprint><date when="2013">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="S1"><title>Objectives</title><p id="P2">Oropharyngeal cancer (OPC) is the 6<sup>th</sup> most common cancer worldwide. Focus on risk factors, improved diagnostic methods and effective management strategies have made it possible to successfully treat OPC. However, the 5-year survival rate has not improved for several years due to multiple treatment complications, tissue morbidity, loss of function and diminished quality of life. Survivors are faced with complications like oral mucositis, hyposalivation, osteoradionecrosis; tissue fibrosis, morbidity from jaw resection; disfigurement and loss of function that further diminish quality of life. The aim of this review is to highlight major complications associated with treatment of OPC via a literature search and review of available options for identification and management of these complications.</p></sec><sec id="S2"><title>Data Sources</title><p id="P3">Relevant publications on oral complications of OPC therapy were thoroughly reviewed from the literature published between the years 1988 and 2012.</p></sec><sec id="S3"><title>Material and Method</title><p id="P4">We evaluated reported incidence, prevalence and risk factors for oral complications of chemotherapy and radiotherapy for OPC. The authors conducted electronic search using English language databases namely PubMed Plus, Medline (Pre-Medline and Medline), Cochrane Database of systematic reviews (evidence-based medicine), Dentistry & Oral sciences source, AccessScience, Embase, Evidence-Based Medicine Reviews Multifile, Google Scholar, ISI Journal Citation Reports, Ovid Multi-Database.</p></sec><sec id="S4"><title>Conclusion</title><p id="P5">We identified the most common complications associated with the treatment of oral cancers. Based on the information gathered, there is evidence that survival of OPC extends beyond eradication of the diseased tissue. Understanding the potential treatment complications and utilizing available resources to prevent and minimize them are important. Caring for OPC survivors should be a multidisciplinary team approach involving the dentist, oncologist, internist and social worker to improve the currently stagnant 5-year survival rate of OPC. More emphasis on improved quality of life after elimination of the cancer will ultimately improve OPC survivorship.</p></sec></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">0342677</journal-id><journal-id journal-id-type="pubmed-jr-id">6830</journal-id><journal-id journal-id-type="nlm-ta">Quintessence Int</journal-id><journal-id journal-id-type="iso-abbrev">Quintessence Int</journal-id><journal-title-group><journal-title>Quintessence international (Berlin, Germany : 1985)</journal-title></journal-title-group><issn pub-type="ppub">0033-6572</issn><issn pub-type="epub">1936-7163</issn></journal-meta><article-meta><article-id pub-id-type="pmid">23444208</article-id><article-id pub-id-type="pmc">3773981</article-id><article-id pub-id-type="doi">10.3290/j.qi.a29050</article-id><article-id pub-id-type="manuscript">NIHMS503842</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Review of the Complications Associated with Treatment of Oropharyngeal Cancer: A Guide to the Dental Practitioner</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Turner</surname><given-names>Lena</given-names></name><degrees>DMD</degrees><xref ref-type="aff" rid="A1">1</xref><xref ref-type="author-notes" rid="FN1">#</xref></contrib><contrib contrib-type="author"><name><surname>Mupparapu</surname><given-names>Muralidhar</given-names></name><degrees>DMD</degrees><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Akintoye</surname><given-names>Sunday O</given-names></name><degrees>BDS, DDS, MS</degrees><xref ref-type="aff" rid="A1">1</xref><xref ref-type="corresp" rid="cor1">*</xref></contrib></contrib-group><aff id="A1"><label>1</label>Department of Oral Medicine, School of Dental Medicine University of Pennsylvania, Philadelphia PA</aff><author-notes><corresp id="cor1"><label>*</label>Corresponding Author, Please address all correspondence to: Sunday O. Akintoye BDS,DDS,MS, University of Pennsylvania, School of Dental Medicine, Department of Oral Medicine, The Robert Schattner Center Room 211, 240 South 40th Street, Philadelphia PA 19104, Phone: 215-898-9932, Fax: 215-573-7853, <email>akintoye@dental.upenn.edu</email></corresp><fn id="FN1"><label>#</label><p id="P1">Former Oral Medicine Resident, currently in private practice in Tulsa, OK.</p></fn></author-notes><pub-date pub-type="nihms-submitted"><day>21</day><month>8</month><year>2013</year></pub-date><pub-date pub-type="ppub"><month>3</month><year>2013</year></pub-date><pub-date pub-type="pmc-release"><day>01</day><month>3</month><year>2014</year></pub-date><volume>44</volume><issue>3</issue><fpage>267</fpage><lpage>279</lpage><abstract><sec id="S1"><title>Objectives</title><p id="P2">Oropharyngeal cancer (OPC) is the 6<sup>th</sup> most common cancer worldwide. Focus on risk factors, improved diagnostic methods and effective management strategies have made it possible to successfully treat OPC. However, the 5-year survival rate has not improved for several years due to multiple treatment complications, tissue morbidity, loss of function and diminished quality of life. Survivors are faced with complications like oral mucositis, hyposalivation, osteoradionecrosis; tissue fibrosis, morbidity from jaw resection; disfigurement and loss of function that further diminish quality of life. The aim of this review is to highlight major complications associated with treatment of OPC via a literature search and review of available options for identification and management of these complications.</p></sec><sec id="S2"><title>Data Sources</title><p id="P3">Relevant publications on oral complications of OPC therapy were thoroughly reviewed from the literature published between the years 1988 and 2012.</p></sec><sec id="S3"><title>Material and Method</title><p id="P4">We evaluated reported incidence, prevalence and risk factors for oral complications of chemotherapy and radiotherapy for OPC. The authors conducted electronic search using English language databases namely PubMed Plus, Medline (Pre-Medline and Medline), Cochrane Database of systematic reviews (evidence-based medicine), Dentistry & Oral sciences source, AccessScience, Embase, Evidence-Based Medicine Reviews Multifile, Google Scholar, ISI Journal Citation Reports, Ovid Multi-Database.</p></sec><sec id="S4"><title>Conclusion</title><p id="P5">We identified the most common complications associated with the treatment of oral cancers. Based on the information gathered, there is evidence that survival of OPC extends beyond eradication of the diseased tissue. Understanding the potential treatment complications and utilizing available resources to prevent and minimize them are important. Caring for OPC survivors should be a multidisciplinary team approach involving the dentist, oncologist, internist and social worker to improve the currently stagnant 5-year survival rate of OPC. More emphasis on improved quality of life after elimination of the cancer will ultimately improve OPC survivorship.</p></sec></abstract><kwd-group><kwd>Cancer</kwd><kwd>Chemotherapy</kwd><kwd>Complications</kwd><kwd>Osteoradionecrosis</kwd><kwd>Radiotherapy</kwd><kwd>Xerostomia</kwd></kwd-group><funding-group><award-group><funding-source country="United States">National Cancer Institute : NCI</funding-source><award-id>K22 CA169089 || CA</award-id></award-group></funding-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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