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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Periodontal microbiota and phospholipases: The Oral Infections and Vascular Disease Epidemiology Study (INVEST)</title><author><name sortKey="Boillot, Adrien" sort="Boillot, Adrien" uniqKey="Boillot A" first="Adrien" last="Boillot">Adrien Boillot</name><affiliation><nlm:aff id="A1"> Department of Periodontology, Rothschild Hospital (AP-HP); University Paris 7, 5 Rue Santerre, Paris, France</nlm:aff></affiliation><affiliation><nlm:aff id="A2"> INSERM U1018, University of Versailles St Quentin. Centre for research in Epidemiology and Population Health, Villejuif, France</nlm:aff></affiliation></author><author><name sortKey="Demmer, Ryan T" sort="Demmer, Ryan T" uniqKey="Demmer R" first="Ryan T." last="Demmer">Ryan T. Demmer</name><affiliation><nlm:aff id="A3"> Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA</nlm:aff></affiliation></author><author><name sortKey="Mallat, Ziad" sort="Mallat, Ziad" uniqKey="Mallat Z" first="Ziad" last="Mallat">Ziad Mallat</name><affiliation><nlm:aff id="A4"> Inserm U970; Cardiovascular Research Center, and Université Paris-Descartes University, F-75015, Paris, France</nlm:aff></affiliation><affiliation><nlm:aff id="A5"> Department of Medicine, University of Cambridge, Cambridge, United Kingdom</nlm:aff></affiliation></author><author><name sortKey="Sacco, Ralph L" sort="Sacco, Ralph L" uniqKey="Sacco R" first="Ralph L." last="Sacco">Ralph L. Sacco</name><affiliation><nlm:aff id="A6"> Department of Neurology, Miller School of Medicine, University of Miami, Miami, FL, USA</nlm:aff></affiliation></author><author><name sortKey="Jacobs, David R" sort="Jacobs, David R" uniqKey="Jacobs D" first="David R." last="Jacobs">David R. Jacobs</name><affiliation><nlm:aff id="A7"> Department of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, MN, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A8"> Department of Nutrition, University of Oslo, Oslo, Norway</nlm:aff></affiliation></author><author><name sortKey="Benessiano, Joelle" sort="Benessiano, Joelle" uniqKey="Benessiano J" first="Joelle" last="Benessiano">Joelle Benessiano</name><affiliation><nlm:aff id="A9"> Service de Biochimie, Hôpital Bichat, Assistance Publique-Hôpitaux de Paris, Paris, France</nlm:aff></affiliation></author><author><name sortKey="Tedgui, Alain" sort="Tedgui, Alain" uniqKey="Tedgui A" first="Alain" last="Tedgui">Alain Tedgui</name><affiliation><nlm:aff id="A4"> Inserm U970; Cardiovascular Research Center, and Université Paris-Descartes University, F-75015, Paris, France</nlm:aff></affiliation></author><author><name sortKey="Rundek, Tatjana" sort="Rundek, Tatjana" uniqKey="Rundek T" first="Tatjana" last="Rundek">Tatjana Rundek</name><affiliation><nlm:aff id="A6"> Department of Neurology, Miller School of Medicine, University of Miami, Miami, FL, USA</nlm:aff></affiliation></author><author><name sortKey="Papapanou, Panos N" sort="Papapanou, Panos N" uniqKey="Papapanou P" first="Panos N." last="Papapanou">Panos N. Papapanou</name><affiliation><nlm:aff id="A10"> Division of Periodontics, Section of Oral and Diagnostic Sciences, College of Dental Medicine, Columbia University, New York, NY, USA</nlm:aff></affiliation></author><author><name sortKey="Desvarieux, Moise" sort="Desvarieux, Moise" uniqKey="Desvarieux M" first="Moïse" last="Desvarieux">Moïse Desvarieux</name><affiliation><nlm:aff id="A3"> Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A11"> INSERM Epidemiology and Biostatistics Research Center, Sorbonne Paris Cité, INSERM UMR 1153, Paris, France</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">26282947</idno><idno type="pmc">4862208</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4862208</idno><idno type="RBID">PMC:4862208</idno><idno type="doi">10.1016/j.atherosclerosis.2015.07.039</idno><date when="2015">2015</date><idno type="wicri:Area/Pmc/Corpus">002589</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002589</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Periodontal microbiota and phospholipases: The Oral Infections and Vascular Disease Epidemiology Study (INVEST)</title><author><name sortKey="Boillot, Adrien" sort="Boillot, Adrien" uniqKey="Boillot A" first="Adrien" last="Boillot">Adrien Boillot</name><affiliation><nlm:aff id="A1"> Department of Periodontology, Rothschild Hospital (AP-HP); University Paris 7, 5 Rue Santerre, Paris, France</nlm:aff></affiliation><affiliation><nlm:aff id="A2"> INSERM U1018, University of Versailles St Quentin. Centre for research in Epidemiology and Population Health, Villejuif, France</nlm:aff></affiliation></author><author><name sortKey="Demmer, Ryan T" sort="Demmer, Ryan T" uniqKey="Demmer R" first="Ryan T." last="Demmer">Ryan T. Demmer</name><affiliation><nlm:aff id="A3"> Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA</nlm:aff></affiliation></author><author><name sortKey="Mallat, Ziad" sort="Mallat, Ziad" uniqKey="Mallat Z" first="Ziad" last="Mallat">Ziad Mallat</name><affiliation><nlm:aff id="A4"> Inserm U970; Cardiovascular Research Center, and Université Paris-Descartes University, F-75015, Paris, France</nlm:aff></affiliation><affiliation><nlm:aff id="A5"> Department of Medicine, University of Cambridge, Cambridge, United Kingdom</nlm:aff></affiliation></author><author><name sortKey="Sacco, Ralph L" sort="Sacco, Ralph L" uniqKey="Sacco R" first="Ralph L." last="Sacco">Ralph L. Sacco</name><affiliation><nlm:aff id="A6"> Department of Neurology, Miller School of Medicine, University of Miami, Miami, FL, USA</nlm:aff></affiliation></author><author><name sortKey="Jacobs, David R" sort="Jacobs, David R" uniqKey="Jacobs D" first="David R." last="Jacobs">David R. Jacobs</name><affiliation><nlm:aff id="A7"> Department of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, MN, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A8"> Department of Nutrition, University of Oslo, Oslo, Norway</nlm:aff></affiliation></author><author><name sortKey="Benessiano, Joelle" sort="Benessiano, Joelle" uniqKey="Benessiano J" first="Joelle" last="Benessiano">Joelle Benessiano</name><affiliation><nlm:aff id="A9"> Service de Biochimie, Hôpital Bichat, Assistance Publique-Hôpitaux de Paris, Paris, France</nlm:aff></affiliation></author><author><name sortKey="Tedgui, Alain" sort="Tedgui, Alain" uniqKey="Tedgui A" first="Alain" last="Tedgui">Alain Tedgui</name><affiliation><nlm:aff id="A4"> Inserm U970; Cardiovascular Research Center, and Université Paris-Descartes University, F-75015, Paris, France</nlm:aff></affiliation></author><author><name sortKey="Rundek, Tatjana" sort="Rundek, Tatjana" uniqKey="Rundek T" first="Tatjana" last="Rundek">Tatjana Rundek</name><affiliation><nlm:aff id="A6"> Department of Neurology, Miller School of Medicine, University of Miami, Miami, FL, USA</nlm:aff></affiliation></author><author><name sortKey="Papapanou, Panos N" sort="Papapanou, Panos N" uniqKey="Papapanou P" first="Panos N." last="Papapanou">Panos N. Papapanou</name><affiliation><nlm:aff id="A10"> Division of Periodontics, Section of Oral and Diagnostic Sciences, College of Dental Medicine, Columbia University, New York, NY, USA</nlm:aff></affiliation></author><author><name sortKey="Desvarieux, Moise" sort="Desvarieux, Moise" uniqKey="Desvarieux M" first="Moïse" last="Desvarieux">Moïse Desvarieux</name><affiliation><nlm:aff id="A3"> Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A11"> INSERM Epidemiology and Biostatistics Research Center, Sorbonne Paris Cité, INSERM UMR 1153, Paris, France</nlm:aff></affiliation></author></analytic><series><title level="j">Atherosclerosis</title><idno type="ISSN">0021-9150</idno><idno type="eISSN">1879-1484</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="S1"><title>Objective</title><p id="P1">Periodontal infections have been linked to cardiovascular disease, including atherosclerosis, and systemic inflammation has been proposed as a possible mediator. Secretory phospholipase A2 (s-PLA2) and Lipoprotein-associated PLA2 (Lp-PLA2) are inflammatory enzymes associated with athero-sclerosis. No data are available on the association between oral microbiota and PLA2s. We studied whether a relationship exists between periodontal microbiota and the activities of these enzymes.</p></sec><sec id="S2"><title>Methods</title><p id="P2">The Oral Infection and Vascular Disease Epidemiology Study (INVEST) collected subgingival biofilms and serum samples from 593 dentate men and women (age 68.7 ± 8.6 years). 4561 biofilm samples were collected in the two most posterior teeth of each quadrant (average 7/participant) for quantitative assessment of 11 bacterial species using DNA–DNA checkerboard hybridization. Mean concentration of s-PLA2 and activities of s-PLA2 and Lp-PLA2 were regressed on tertiles of etiologic dominance (ED). ED is defined as the level of presumed periodontopathic species/combined level of all eleven species measured, and represents the relative abundance of periodontopathic organisms. Analyses were adjusted for age, sex, race/ethnicity, education, smoking, BMI, diabetes, LDL cholesterol and HDL cholesterol, and systolic blood pressure.</p></sec><sec id="S3"><title>Results</title><p id="P3">Higher levels of s-PLA2 activity were observed across increasing tertiles of etiologic dominance (0.66 ± 0.04 nmol ml<sup>−1</sup> min<sup>−1</sup>, 0.73 ± 0.04 nmol ml<sup>−1</sup> min<sup>−1</sup>, 0.89 ± 0.04 nmol ml<sup>−1</sup> min<sup>−1</sup>; p < 0.001), with also a trend of association between Lp-PLA2 activity and ED (p = 0.07), while s-PLA2 concentration was unrelated to ED.</p></sec><sec id="S4"><title>Conclusion</title><p id="P4">Increasingly greater s-PLA2 activity at higher tertiles of etiologic dominance may provide a mechanistic explanatory link of the relationship between periodontal microbiota and vascular diseases. Additional studies investigating the role of s-PLA2 are needed.</p></sec></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">0242543</journal-id><journal-id journal-id-type="pubmed-jr-id">890</journal-id><journal-id journal-id-type="nlm-ta">Atherosclerosis</journal-id><journal-id journal-id-type="iso-abbrev">Atherosclerosis</journal-id><journal-title-group><journal-title>Atherosclerosis</journal-title></journal-title-group><issn pub-type="ppub">0021-9150</issn><issn pub-type="epub">1879-1484</issn></journal-meta><article-meta><article-id pub-id-type="pmid">26282947</article-id><article-id pub-id-type="pmc">4862208</article-id><article-id pub-id-type="doi">10.1016/j.atherosclerosis.2015.07.039</article-id><article-id pub-id-type="manuscript">NIHMS757891</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Periodontal microbiota and phospholipases: The Oral Infections and Vascular Disease Epidemiology Study (INVEST)</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Boillot</surname><given-names>Adrien</given-names></name><xref ref-type="aff" rid="A1">a</xref><xref ref-type="aff" rid="A2">b</xref></contrib><contrib contrib-type="author"><name><surname>Demmer</surname><given-names>Ryan T.</given-names></name><xref ref-type="aff" rid="A3">c</xref></contrib><contrib contrib-type="author"><name><surname>Mallat</surname><given-names>Ziad</given-names></name><xref ref-type="aff" rid="A4">d</xref><xref ref-type="aff" rid="A5">e</xref></contrib><contrib contrib-type="author"><name><surname>Sacco</surname><given-names>Ralph L.</given-names></name><xref ref-type="aff" rid="A6">f</xref></contrib><contrib contrib-type="author"><name><surname>Jacobs</surname><given-names>David R.</given-names></name><xref ref-type="aff" rid="A7">g</xref><xref ref-type="aff" rid="A8">h</xref></contrib><contrib contrib-type="author"><name><surname>Benessiano</surname><given-names>Joelle</given-names></name><xref ref-type="aff" rid="A9">i</xref></contrib><contrib contrib-type="author"><name><surname>Tedgui</surname><given-names>Alain</given-names></name><xref ref-type="aff" rid="A4">d</xref></contrib><contrib contrib-type="author"><name><surname>Rundek</surname><given-names>Tatjana</given-names></name><xref ref-type="aff" rid="A6">f</xref></contrib><contrib contrib-type="author"><name><surname>Papapanou</surname><given-names>Panos N.</given-names></name><xref ref-type="aff" rid="A10">j</xref></contrib><contrib contrib-type="author"><name><surname>Desvarieux</surname><given-names>Moïse</given-names></name><xref ref-type="aff" rid="A3">c</xref><xref ref-type="aff" rid="A11">k</xref><xref ref-type="corresp" rid="CR1">*</xref></contrib></contrib-group><aff id="A1"><label>a</label> Department of Periodontology, Rothschild Hospital (AP-HP); University Paris 7, 5 Rue Santerre, Paris, France</aff><aff id="A2"><label>b</label> INSERM U1018, University of Versailles St Quentin. Centre for research in Epidemiology and Population Health, Villejuif, France</aff><aff id="A3"><label>c</label> Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA</aff><aff id="A4"><label>d</label> Inserm U970; Cardiovascular Research Center, and Université Paris-Descartes University, F-75015, Paris, France</aff><aff id="A5"><label>e</label> Department of Medicine, University of Cambridge, Cambridge, United Kingdom</aff><aff id="A6"><label>f</label> Department of Neurology, Miller School of Medicine, University of Miami, Miami, FL, USA</aff><aff id="A7"><label>g</label> Department of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, MN, USA</aff><aff id="A8"><label>h</label> Department of Nutrition, University of Oslo, Oslo, Norway</aff><aff id="A9"><label>i</label> Service de Biochimie, Hôpital Bichat, Assistance Publique-Hôpitaux de Paris, Paris, France</aff><aff id="A10"><label>j</label> Division of Periodontics, Section of Oral and Diagnostic Sciences, College of Dental Medicine, Columbia University, New York, NY, USA</aff><aff id="A11"><label>k</label> INSERM Epidemiology and Biostatistics Research Center, Sorbonne Paris Cité, INSERM UMR 1153, Paris, France</aff><author-notes><corresp id="CR1"><label>*</label> Corresponding author. Department of Epidemiology, Mailman School of Public Health, Columbia University, 722 W 168th Street, Room 525, New York, NY 10032, USA. <email>mdesvarieux@columbia.edu</email> (M. Desvarieux).</corresp></author-notes><pub-date pub-type="nihms-submitted"><day>11</day><month>2</month><year>2016</year></pub-date><pub-date pub-type="epub"><day>22</day><month>7</month><year>2015</year></pub-date><pub-date pub-type="ppub"><month>10</month><year>2015</year></pub-date><pub-date pub-type="pmc-release"><day>10</day><month>5</month><year>2016</year></pub-date><volume>242</volume><issue>2</issue><fpage>418</fpage><lpage>423</lpage><pmc-comment>elocation-id from pubmed: 10.1016/j.atherosclerosis.2015.07.039</pmc-comment>
<abstract><sec id="S1"><title>Objective</title><p id="P1">Periodontal infections have been linked to cardiovascular disease, including atherosclerosis, and systemic inflammation has been proposed as a possible mediator. Secretory phospholipase A2 (s-PLA2) and Lipoprotein-associated PLA2 (Lp-PLA2) are inflammatory enzymes associated with athero-sclerosis. No data are available on the association between oral microbiota and PLA2s. We studied whether a relationship exists between periodontal microbiota and the activities of these enzymes.</p></sec><sec id="S2"><title>Methods</title><p id="P2">The Oral Infection and Vascular Disease Epidemiology Study (INVEST) collected subgingival biofilms and serum samples from 593 dentate men and women (age 68.7 ± 8.6 years). 4561 biofilm samples were collected in the two most posterior teeth of each quadrant (average 7/participant) for quantitative assessment of 11 bacterial species using DNA–DNA checkerboard hybridization. Mean concentration of s-PLA2 and activities of s-PLA2 and Lp-PLA2 were regressed on tertiles of etiologic dominance (ED). ED is defined as the level of presumed periodontopathic species/combined level of all eleven species measured, and represents the relative abundance of periodontopathic organisms. Analyses were adjusted for age, sex, race/ethnicity, education, smoking, BMI, diabetes, LDL cholesterol and HDL cholesterol, and systolic blood pressure.</p></sec><sec id="S3"><title>Results</title><p id="P3">Higher levels of s-PLA2 activity were observed across increasing tertiles of etiologic dominance (0.66 ± 0.04 nmol ml<sup>−1</sup> min<sup>−1</sup>, 0.73 ± 0.04 nmol ml<sup>−1</sup> min<sup>−1</sup>, 0.89 ± 0.04 nmol ml<sup>−1</sup> min<sup>−1</sup>; p < 0.001), with also a trend of association between Lp-PLA2 activity and ED (p = 0.07), while s-PLA2 concentration was unrelated to ED.</p></sec><sec id="S4"><title>Conclusion</title><p id="P4">Increasingly greater s-PLA2 activity at higher tertiles of etiologic dominance may provide a mechanistic explanatory link of the relationship between periodontal microbiota and vascular diseases. Additional studies investigating the role of s-PLA2 are needed.</p></sec></abstract><kwd-group><kwd>Periodontitis</kwd><kwd>Phospholipases</kwd><kwd>Cardiovascular diseases</kwd><kwd>Atherosclerosis</kwd></kwd-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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