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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Novel Biomarkers of Periodontitis and/or Obesity in Saliva – An Exploratory Analysis</title><author><name sortKey="Recker, Erica N" sort="Recker, Erica N" uniqKey="Recker E" first="Erica N." last="Recker">Erica N. Recker</name><affiliation><nlm:aff id="A1">Dows Institute of Dental Research, University of Iowa College of Dentistry, Iowa City, IA 52242</nlm:aff></affiliation></author><author><name sortKey="Brogden, Kim A" sort="Brogden, Kim A" uniqKey="Brogden K" first="Kim A." last="Brogden">Kim A. Brogden</name><affiliation><nlm:aff id="A1">Dows Institute of Dental Research, University of Iowa College of Dentistry, Iowa City, IA 52242</nlm:aff></affiliation><affiliation><nlm:aff id="A2">Department of Periodontics, University of Iowa College of Dentistry, Iowa City, IA 52242</nlm:aff></affiliation></author><author><name sortKey="Avila Ortiz, Gustavo" sort="Avila Ortiz, Gustavo" uniqKey="Avila Ortiz G" first="Gustavo" last="Avila-Ortiz">Gustavo Avila-Ortiz</name><affiliation><nlm:aff id="A2">Department of Periodontics, University of Iowa College of Dentistry, Iowa City, IA 52242</nlm:aff></affiliation></author><author><name sortKey="Fischer, Carol L" sort="Fischer, Carol L" uniqKey="Fischer C" first="Carol L." last="Fischer">Carol L. Fischer</name><affiliation><nlm:aff id="A1">Dows Institute of Dental Research, University of Iowa College of Dentistry, Iowa City, IA 52242</nlm:aff></affiliation></author><author><name sortKey="Pagan Rivera, Keyla" sort="Pagan Rivera, Keyla" uniqKey="Pagan Rivera K" first="Keyla" last="Pagan-Rivera">Keyla Pagan-Rivera</name><affiliation><nlm:aff id="A3">Biostatistics and Research Design, University of Iowa College of Dentistry, Iowa City, IA 52242</nlm:aff></affiliation><affiliation><nlm:aff id="A4">Department of Biostatistics, University of Iowa College of Public Health, Iowa City, IA 52242</nlm:aff></affiliation></author><author><name sortKey="Dawson, Deborah V" sort="Dawson, Deborah V" uniqKey="Dawson D" first="Deborah V." last="Dawson">Deborah V. Dawson</name><affiliation><nlm:aff id="A1">Dows Institute of Dental Research, University of Iowa College of Dentistry, Iowa City, IA 52242</nlm:aff></affiliation><affiliation><nlm:aff id="A3">Biostatistics and Research Design, University of Iowa College of Dentistry, Iowa City, IA 52242</nlm:aff></affiliation></author><author><name sortKey="Smith, Katherine M" sort="Smith, Katherine M" uniqKey="Smith K" first="Katherine M." last="Smith">Katherine M. Smith</name><affiliation><nlm:aff id="A2">Department of Periodontics, University of Iowa College of Dentistry, Iowa City, IA 52242</nlm:aff></affiliation></author><author><name sortKey="Elangovan, Satheesh" sort="Elangovan, Satheesh" uniqKey="Elangovan S" first="Satheesh" last="Elangovan">Satheesh Elangovan</name><affiliation><nlm:aff id="A2">Department of Periodontics, University of Iowa College of Dentistry, Iowa City, IA 52242</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">26263539</idno><idno type="pmc">4567926</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4567926</idno><idno type="RBID">PMC:4567926</idno><idno type="doi">10.1016/j.archoralbio.2015.07.006</idno><date when="2015">2015</date><idno type="wicri:Area/Pmc/Corpus">002586</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002586</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Novel Biomarkers of Periodontitis and/or Obesity in Saliva – An Exploratory Analysis</title><author><name sortKey="Recker, Erica N" sort="Recker, Erica N" uniqKey="Recker E" first="Erica N." last="Recker">Erica N. Recker</name><affiliation><nlm:aff id="A1">Dows Institute of Dental Research, University of Iowa College of Dentistry, Iowa City, IA 52242</nlm:aff></affiliation></author><author><name sortKey="Brogden, Kim A" sort="Brogden, Kim A" uniqKey="Brogden K" first="Kim A." last="Brogden">Kim A. Brogden</name><affiliation><nlm:aff id="A1">Dows Institute of Dental Research, University of Iowa College of Dentistry, Iowa City, IA 52242</nlm:aff></affiliation><affiliation><nlm:aff id="A2">Department of Periodontics, University of Iowa College of Dentistry, Iowa City, IA 52242</nlm:aff></affiliation></author><author><name sortKey="Avila Ortiz, Gustavo" sort="Avila Ortiz, Gustavo" uniqKey="Avila Ortiz G" first="Gustavo" last="Avila-Ortiz">Gustavo Avila-Ortiz</name><affiliation><nlm:aff id="A2">Department of Periodontics, University of Iowa College of Dentistry, Iowa City, IA 52242</nlm:aff></affiliation></author><author><name sortKey="Fischer, Carol L" sort="Fischer, Carol L" uniqKey="Fischer C" first="Carol L." last="Fischer">Carol L. Fischer</name><affiliation><nlm:aff id="A1">Dows Institute of Dental Research, University of Iowa College of Dentistry, Iowa City, IA 52242</nlm:aff></affiliation></author><author><name sortKey="Pagan Rivera, Keyla" sort="Pagan Rivera, Keyla" uniqKey="Pagan Rivera K" first="Keyla" last="Pagan-Rivera">Keyla Pagan-Rivera</name><affiliation><nlm:aff id="A3">Biostatistics and Research Design, University of Iowa College of Dentistry, Iowa City, IA 52242</nlm:aff></affiliation><affiliation><nlm:aff id="A4">Department of Biostatistics, University of Iowa College of Public Health, Iowa City, IA 52242</nlm:aff></affiliation></author><author><name sortKey="Dawson, Deborah V" sort="Dawson, Deborah V" uniqKey="Dawson D" first="Deborah V." last="Dawson">Deborah V. Dawson</name><affiliation><nlm:aff id="A1">Dows Institute of Dental Research, University of Iowa College of Dentistry, Iowa City, IA 52242</nlm:aff></affiliation><affiliation><nlm:aff id="A3">Biostatistics and Research Design, University of Iowa College of Dentistry, Iowa City, IA 52242</nlm:aff></affiliation></author><author><name sortKey="Smith, Katherine M" sort="Smith, Katherine M" uniqKey="Smith K" first="Katherine M." last="Smith">Katherine M. Smith</name><affiliation><nlm:aff id="A2">Department of Periodontics, University of Iowa College of Dentistry, Iowa City, IA 52242</nlm:aff></affiliation></author><author><name sortKey="Elangovan, Satheesh" sort="Elangovan, Satheesh" uniqKey="Elangovan S" first="Satheesh" last="Elangovan">Satheesh Elangovan</name><affiliation><nlm:aff id="A2">Department of Periodontics, University of Iowa College of Dentistry, Iowa City, IA 52242</nlm:aff></affiliation></author></analytic><series><title level="j">Archives of oral biology</title><idno type="ISSN">0003-9969</idno><idno type="eISSN">1879-1506</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="S1"><title>Objective</title><p id="P1">Recent studies point to the clinical and research utility of saliva as a valuable diagnostic aid for monitoring periodontal health. The objectives of this study were to detect novel biomarkers attributed to chronic inflammation in saliva and to determine if the levels of these markers correlate with severity of periodontitis and with standard obesity measures in participants in a periodontal maintenance program.</p></sec><sec id="S2"><title>Design</title><p id="P2">In this cross-sectional assessment of 63 participants, unstimulated whole saliva was collected after recording anthropometric and clinical parameters of obesity and periodontitis, respectively. The levels of interleukin-1 receptor antagonist (IL-1ra), sCD40L, granzyme B and alpha-fetoprotein (AFP) in saliva were determined using multiplex proteomic immunoassays. The correlation between the four tested biomarker concentrations and obesity/periodontal measures was determined.</p></sec><sec id="S3"><title>Results</title><p id="P3">Positive correlation between fat% and granzyme B levels (r=0.292; p=0.020) and negative correlation between BMI and sCD40L (r=0.256;p=0.043) was observed. In addition, positive correlation between severity of periodontal disease and levels of IL1-ra (r=0.253; p=0.046) and negative correlation between periodontitis severity and sCD40L salivary levels (r=0.272; p=0.031) was noted. None of the above correlations remained statistically significant after multiple comparisons adjustment. After adjustment for clinical covariates, the relationship between sCD40L and periodontal severity remained suggestive (p=0.081).</p></sec><sec id="S4"><title>Conclusions</title><p id="P4">Levels of four novel biomarkers of periodontitis were detectable in saliva of subjects enrolled in a periodontal maintenance program. Prospective studies with larger sample sizes and other populations are warranted to explore the diagnostic applicability of these markers.</p></sec></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">0116711</journal-id><journal-id journal-id-type="pubmed-jr-id">809</journal-id><journal-id journal-id-type="nlm-ta">Arch Oral Biol</journal-id><journal-id journal-id-type="iso-abbrev">Arch. Oral Biol.</journal-id><journal-title-group><journal-title>Archives of oral biology</journal-title></journal-title-group><issn pub-type="ppub">0003-9969</issn><issn pub-type="epub">1879-1506</issn></journal-meta><article-meta><article-id pub-id-type="pmid">26263539</article-id><article-id pub-id-type="pmc">4567926</article-id><article-id pub-id-type="doi">10.1016/j.archoralbio.2015.07.006</article-id><article-id pub-id-type="manuscript">NIHMS714507</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Novel Biomarkers of Periodontitis and/or Obesity in Saliva – An Exploratory Analysis</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Recker</surname><given-names>Erica N.</given-names></name><degrees>BS</degrees><xref ref-type="aff" rid="A1">*</xref></contrib><contrib contrib-type="author"><name><surname>Brogden</surname><given-names>Kim A.</given-names></name><degrees>PhD</degrees><xref ref-type="aff" rid="A1">*</xref><xref ref-type="aff" rid="A2">†</xref></contrib><contrib contrib-type="author"><name><surname>Avila-Ortiz</surname><given-names>Gustavo</given-names></name><degrees>DDS, MS, PhD</degrees><xref ref-type="aff" rid="A2">†</xref></contrib><contrib contrib-type="author"><name><surname>Fischer</surname><given-names>Carol L.</given-names></name><degrees>PhD</degrees><xref ref-type="aff" rid="A1">*</xref></contrib><contrib contrib-type="author"><name><surname>Pagan-Rivera</surname><given-names>Keyla</given-names></name><degrees>MS</degrees><xref ref-type="aff" rid="A3">§</xref><xref ref-type="aff" rid="A4">‡</xref></contrib><contrib contrib-type="author"><name><surname>Dawson</surname><given-names>Deborah V.</given-names></name><degrees>PhD</degrees><xref ref-type="aff" rid="A1">*</xref><xref ref-type="aff" rid="A3">§</xref></contrib><contrib contrib-type="author"><name><surname>Smith</surname><given-names>Katherine M.</given-names></name><degrees>DDS</degrees><xref ref-type="aff" rid="A2">†</xref></contrib><contrib contrib-type="author"><name><surname>Elangovan</surname><given-names>Satheesh</given-names></name><degrees>BDS, ScD, DMSc</degrees><xref ref-type="aff" rid="A2">†</xref></contrib></contrib-group><aff id="A1"><label>*</label>Dows Institute of Dental Research, University of Iowa College of Dentistry, Iowa City, IA 52242</aff><aff id="A2"><label>†</label>Department of Periodontics, University of Iowa College of Dentistry, Iowa City, IA 52242</aff><aff id="A3"><label>§</label>Biostatistics and Research Design, University of Iowa College of Dentistry, Iowa City, IA 52242</aff><aff id="A4"><label>‡</label>Department of Biostatistics, University of Iowa College of Public Health, Iowa City, IA 52242</aff><author-notes><corresp id="cor1"><bold>Corresponding Author:</bold> Dr. Satheesh Elangovan, Assistant Professor, Department of Periodontics, The University of Iowa College of Dentistry, S464, Iowa City, IA – 52242, Tel: 319 335 7543 / Fax: 319 335 7239, <email>satheesh-elangovan@uiowa.edu</email></corresp></author-notes><pub-date pub-type="nihms-submitted"><day>12</day><month>8</month><year>2015</year></pub-date><pub-date pub-type="epub"><day>14</day><month>7</month><year>2015</year></pub-date><pub-date pub-type="ppub"><month>10</month><year>2015</year></pub-date><pub-date pub-type="pmc-release"><day>01</day><month>10</month><year>2016</year></pub-date><volume>60</volume><issue>10</issue><fpage>1503</fpage><lpage>1509</lpage><pmc-comment>elocation-id from pubmed: 10.1016/j.archoralbio.2015.07.006</pmc-comment>
<abstract><sec id="S1"><title>Objective</title><p id="P1">Recent studies point to the clinical and research utility of saliva as a valuable diagnostic aid for monitoring periodontal health. The objectives of this study were to detect novel biomarkers attributed to chronic inflammation in saliva and to determine if the levels of these markers correlate with severity of periodontitis and with standard obesity measures in participants in a periodontal maintenance program.</p></sec><sec id="S2"><title>Design</title><p id="P2">In this cross-sectional assessment of 63 participants, unstimulated whole saliva was collected after recording anthropometric and clinical parameters of obesity and periodontitis, respectively. The levels of interleukin-1 receptor antagonist (IL-1ra), sCD40L, granzyme B and alpha-fetoprotein (AFP) in saliva were determined using multiplex proteomic immunoassays. The correlation between the four tested biomarker concentrations and obesity/periodontal measures was determined.</p></sec><sec id="S3"><title>Results</title><p id="P3">Positive correlation between fat% and granzyme B levels (r=0.292; p=0.020) and negative correlation between BMI and sCD40L (r=0.256;p=0.043) was observed. In addition, positive correlation between severity of periodontal disease and levels of IL1-ra (r=0.253; p=0.046) and negative correlation between periodontitis severity and sCD40L salivary levels (r=0.272; p=0.031) was noted. None of the above correlations remained statistically significant after multiple comparisons adjustment. After adjustment for clinical covariates, the relationship between sCD40L and periodontal severity remained suggestive (p=0.081).</p></sec><sec id="S4"><title>Conclusions</title><p id="P4">Levels of four novel biomarkers of periodontitis were detectable in saliva of subjects enrolled in a periodontal maintenance program. Prospective studies with larger sample sizes and other populations are warranted to explore the diagnostic applicability of these markers.</p></sec></abstract><kwd-group><kwd>Saliva</kwd><kwd>diagnostics</kwd><kwd>periodontal disease</kwd><kwd>obesity</kwd></kwd-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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