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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Efficacy of a new coating of implant-abutment connections in reducing bacterial loading: an <italic>in vitro</italic> study</title><author><name sortKey="Lauritano, D" sort="Lauritano, D" uniqKey="Lauritano D" first="D." last="Lauritano">D. Lauritano</name><affiliation><nlm:aff id="af1-1-10">Department of Translational Medicine and Surgery, Neuroscience Center of Milan, University of Milano Bicocca, Monza, Italy</nlm:aff></affiliation></author><author><name sortKey="Bignozzi, C A" sort="Bignozzi, C A" uniqKey="Bignozzi C" first="C. A." last="Bignozzi">C. A. Bignozzi</name><affiliation><nlm:aff id="af2-1-10">Department of Chemical and Pharmaceutical Sciences, University of Ferrara, Ferrara, Italy</nlm:aff></affiliation></author><author><name sortKey="Pazzi, D" sort="Pazzi, D" uniqKey="Pazzi D" first="D." last="Pazzi">D. Pazzi</name><affiliation><nlm:aff id="af2-1-10">Department of Chemical and Pharmaceutical Sciences, University of Ferrara, Ferrara, Italy</nlm:aff></affiliation></author><author><name sortKey="Cura, F" sort="Cura, F" uniqKey="Cura F" first="F." last="Cura">F. Cura</name><affiliation><nlm:aff id="af3-1-10">Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Bologna, Italy</nlm:aff></affiliation></author><author><name sortKey="Carinci, F" sort="Carinci, F" uniqKey="Carinci F" first="F." last="Carinci">F. Carinci</name><affiliation><nlm:aff id="af4-1-10">Department of Morphology, Surgery and Experimental Medicine, University of Ferrara, Ferrara, Italy</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">28757930</idno><idno type="pmc">5516421</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5516421</idno><idno type="RBID">PMC:5516421</idno><idno type="doi">10.11138/orl/2017.10.1.001</idno><date when="2017">2017</date><idno type="wicri:Area/Pmc/Corpus">002534</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002534</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Efficacy of a new coating of implant-abutment connections in reducing bacterial loading: an <italic>in vitro</italic> study</title><author><name sortKey="Lauritano, D" sort="Lauritano, D" uniqKey="Lauritano D" first="D." last="Lauritano">D. Lauritano</name><affiliation><nlm:aff id="af1-1-10">Department of Translational Medicine and Surgery, Neuroscience Center of Milan, University of Milano Bicocca, Monza, Italy</nlm:aff></affiliation></author><author><name sortKey="Bignozzi, C A" sort="Bignozzi, C A" uniqKey="Bignozzi C" first="C. A." last="Bignozzi">C. A. Bignozzi</name><affiliation><nlm:aff id="af2-1-10">Department of Chemical and Pharmaceutical Sciences, University of Ferrara, Ferrara, Italy</nlm:aff></affiliation></author><author><name sortKey="Pazzi, D" sort="Pazzi, D" uniqKey="Pazzi D" first="D." last="Pazzi">D. Pazzi</name><affiliation><nlm:aff id="af2-1-10">Department of Chemical and Pharmaceutical Sciences, University of Ferrara, Ferrara, Italy</nlm:aff></affiliation></author><author><name sortKey="Cura, F" sort="Cura, F" uniqKey="Cura F" first="F." last="Cura">F. Cura</name><affiliation><nlm:aff id="af3-1-10">Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Bologna, Italy</nlm:aff></affiliation></author><author><name sortKey="Carinci, F" sort="Carinci, F" uniqKey="Carinci F" first="F." last="Carinci">F. Carinci</name><affiliation><nlm:aff id="af4-1-10">Department of Morphology, Surgery and Experimental Medicine, University of Ferrara, Ferrara, Italy</nlm:aff></affiliation></author></analytic><series><title level="j">Oral & Implantology</title><idno type="ISSN">1974-5648</idno><idno type="eISSN">2035-2468</idno><imprint><date when="2017">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><title>SUMMARY</title><sec><title>Background</title><p>Titanium is the gold standard for dental implants, since it has demonstrated excellent biocompatibility and osseointegration properties. The rate of osseointegration is however affected by the surface morphology and peri-implant infections may affect fixture and the long-term osseointegration outcome. Thus chemical composition of a coating at the implant-abutment junction (IAJ) surface is expected to play a key role in preventing bacterial infection.</p></sec><sec><title>Purpose</title><p>In the present study a new antimicrobial polysiloxane coating functionalized with chlorexidine digluconate (PXT) has been tested in an <italic>in vitro</italic> model.</p></sec><sec><title>Materials and methods</title><p>Twenty implants were coated in the internal chamber with PXT and twenty were used as controls.</p></sec><sec><title>Results and conclusions</title><p>Ten of the coated implants, preliminarily tested against Gram positive and negative bacteria and fungi, showed a complete inactivation of the microbial species after a 15 min contact. On the remaining ten treated implants a series of microbiological tests and PCR analysis, after contamination of the implant external medium, in which the implant have been immersed, with genetic modified <italic>Tannerella forsythia</italic> (TF) and <italic>Porphyromonas Gingivalis</italic> (PG), leads to the conclusion that the coating is capable of inactivating the microbial species penetrating the internal of the implant through the implant abutment junction.</p></sec></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Oral Implantol (Rome)</journal-id><journal-id journal-id-type="iso-abbrev">Oral Implantol (Rome)</journal-id><journal-id journal-id-type="publisher-id">OAI</journal-id><journal-title-group><journal-title>Oral & Implantology</journal-title></journal-title-group><issn pub-type="ppub">1974-5648</issn><issn pub-type="epub">2035-2468</issn><publisher><publisher-name>CIC Edizioni Internazionali</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">28757930</article-id><article-id pub-id-type="pmc">5516421</article-id><article-id pub-id-type="doi">10.11138/orl/2017.10.1.001</article-id><article-id pub-id-type="publisher-id">1-10</article-id><article-categories><subj-group subj-group-type="heading"><subject>Original Research Article</subject></subj-group></article-categories><title-group><article-title>Efficacy of a new coating of implant-abutment connections in reducing bacterial loading: an <italic>in vitro</italic> study</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>LAURITANO</surname><given-names>D.</given-names></name><xref ref-type="aff" rid="af1-1-10">1</xref></contrib><contrib contrib-type="author"><name><surname>BIGNOZZI</surname><given-names>C.A.</given-names></name><xref ref-type="aff" rid="af2-1-10">2</xref></contrib><contrib contrib-type="author"><name><surname>PAZZI</surname><given-names>D.</given-names></name><xref ref-type="aff" rid="af2-1-10">2</xref></contrib><contrib contrib-type="author"><name><surname>CURA</surname><given-names>F.</given-names></name><xref ref-type="aff" rid="af3-1-10">3</xref></contrib><contrib contrib-type="author"><name><surname>CARINCI</surname><given-names>F.</given-names></name><xref ref-type="aff" rid="af4-1-10">4</xref><xref ref-type="corresp" rid="c1-1-10"></xref></contrib></contrib-group><aff id="af1-1-10"><label>1</label>Department of Translational Medicine and Surgery, Neuroscience Center of Milan, University of Milano Bicocca, Monza, Italy</aff><aff id="af2-1-10"><label>2</label>Department of Chemical and Pharmaceutical Sciences, University of Ferrara, Ferrara, Italy</aff><aff id="af3-1-10"><label>3</label>Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Bologna, Italy</aff><aff id="af4-1-10"><label>4</label>Department of Morphology, Surgery and Experimental Medicine, University of Ferrara, Ferrara, Italy</aff><author-notes><corresp id="c1-1-10">Correspondence to: Prof. Francesco Carinci, MD, Department of Morphology, Surgery and Experimental Medicine, University of Ferrara, Corso Giovecca 203, 44100 Ferrara, Italy, Phone/Fax: +39.0532.455582, E-mail: <email>crc@unife.it</email>, web: <ext-link ext-link-type="uri" xlink:href="www.carinci.org">www.carinci.org</ext-link></corresp></author-notes><pub-date pub-type="collection"><season>Jan-Mar</season><year>2017</year></pub-date><pub-date pub-type="epub"><day>10</day><month>4</month><year>2017</year></pub-date><volume>10</volume><issue>1</issue><fpage>1</fpage><lpage>10</lpage><permissions><copyright-statement>Copyright © 2017, CIC Edizioni Internazionali</copyright-statement><copyright-year>2017</copyright-year></permissions><abstract><title>SUMMARY</title><sec><title>Background</title><p>Titanium is the gold standard for dental implants, since it has demonstrated excellent biocompatibility and osseointegration properties. The rate of osseointegration is however affected by the surface morphology and peri-implant infections may affect fixture and the long-term osseointegration outcome. Thus chemical composition of a coating at the implant-abutment junction (IAJ) surface is expected to play a key role in preventing bacterial infection.</p></sec><sec><title>Purpose</title><p>In the present study a new antimicrobial polysiloxane coating functionalized with chlorexidine digluconate (PXT) has been tested in an <italic>in vitro</italic> model.</p></sec><sec><title>Materials and methods</title><p>Twenty implants were coated in the internal chamber with PXT and twenty were used as controls.</p></sec><sec><title>Results and conclusions</title><p>Ten of the coated implants, preliminarily tested against Gram positive and negative bacteria and fungi, showed a complete inactivation of the microbial species after a 15 min contact. On the remaining ten treated implants a series of microbiological tests and PCR analysis, after contamination of the implant external medium, in which the implant have been immersed, with genetic modified <italic>Tannerella forsythia</italic> (TF) and <italic>Porphyromonas Gingivalis</italic> (PG), leads to the conclusion that the coating is capable of inactivating the microbial species penetrating the internal of the implant through the implant abutment junction.</p></sec></abstract><kwd-group><kwd>implant-abutment connection</kwd><kwd>antimicrobial siloxane coating</kwd><kwd>peri-implantitis</kwd></kwd-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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