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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Bone augmentation in rabbit tibia using microfixed cobalt-chromium membranes with whole blood, tricalcium phosphate and bone marrow cells</title><author><name sortKey="Decco, Oscar" sort="Decco, Oscar" uniqKey="Decco O" first="Oscar" last="Decco">Oscar Decco</name><affiliation><nlm:aff id="au1"><institution>Department of Bioengineering, Faculty of Engineering, Universidad Nacional de Entre Rios</institution><addr-line>Argentina</addr-line></nlm:aff></affiliation></author><author><name sortKey="Cura, Andrea" sort="Cura, Andrea" uniqKey="Cura A" first="Andrea" last="Cura">Andrea Cura</name><affiliation><nlm:aff id="au1"><institution>Department of Bioengineering, Faculty of Engineering, Universidad Nacional de Entre Rios</institution><addr-line>Argentina</addr-line></nlm:aff></affiliation></author><author><name sortKey="Beltran, Victor" sort="Beltran, Victor" uniqKey="Beltran V" first="Víctor" last="Beltrán">Víctor Beltrán</name><affiliation><nlm:aff id="au2"><institution>Department of Oral and Maxillofacial Surgery, Georg-August-University Hospital</institution><addr-line>Göttingen, Germany</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="au3"><institution>CIMOFIR Research Center, Faculty of Dentistry, Universidad de La Frontera</institution><addr-line>Temuco, Chile</addr-line></nlm:aff></affiliation></author><author><name sortKey="Lezcano, Maria" sort="Lezcano, Maria" uniqKey="Lezcano M" first="María" last="Lezcano">María Lezcano</name><affiliation><nlm:aff id="au1"><institution>Department of Bioengineering, Faculty of Engineering, Universidad Nacional de Entre Rios</institution><addr-line>Argentina</addr-line></nlm:aff></affiliation></author><author><name sortKey="Engelke, Wilfried" sort="Engelke, Wilfried" uniqKey="Engelke W" first="Wilfried" last="Engelke">Wilfried Engelke</name><affiliation><nlm:aff id="au2"><institution>Department of Oral and Maxillofacial Surgery, Georg-August-University Hospital</institution><addr-line>Göttingen, Germany</addr-line></nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">25784982</idno><idno type="pmc">4358437</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4358437</idno><idno type="RBID">PMC:4358437</idno><date when="2015">2015</date><idno type="wicri:Area/Pmc/Corpus">002338</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002338</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Bone augmentation in rabbit tibia using microfixed cobalt-chromium membranes with whole blood, tricalcium phosphate and bone marrow cells</title><author><name sortKey="Decco, Oscar" sort="Decco, Oscar" uniqKey="Decco O" first="Oscar" last="Decco">Oscar Decco</name><affiliation><nlm:aff id="au1"><institution>Department of Bioengineering, Faculty of Engineering, Universidad Nacional de Entre Rios</institution><addr-line>Argentina</addr-line></nlm:aff></affiliation></author><author><name sortKey="Cura, Andrea" sort="Cura, Andrea" uniqKey="Cura A" first="Andrea" last="Cura">Andrea Cura</name><affiliation><nlm:aff id="au1"><institution>Department of Bioengineering, Faculty of Engineering, Universidad Nacional de Entre Rios</institution><addr-line>Argentina</addr-line></nlm:aff></affiliation></author><author><name sortKey="Beltran, Victor" sort="Beltran, Victor" uniqKey="Beltran V" first="Víctor" last="Beltrán">Víctor Beltrán</name><affiliation><nlm:aff id="au2"><institution>Department of Oral and Maxillofacial Surgery, Georg-August-University Hospital</institution><addr-line>Göttingen, Germany</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="au3"><institution>CIMOFIR Research Center, Faculty of Dentistry, Universidad de La Frontera</institution><addr-line>Temuco, Chile</addr-line></nlm:aff></affiliation></author><author><name sortKey="Lezcano, Maria" sort="Lezcano, Maria" uniqKey="Lezcano M" first="María" last="Lezcano">María Lezcano</name><affiliation><nlm:aff id="au1"><institution>Department of Bioengineering, Faculty of Engineering, Universidad Nacional de Entre Rios</institution><addr-line>Argentina</addr-line></nlm:aff></affiliation></author><author><name sortKey="Engelke, Wilfried" sort="Engelke, Wilfried" uniqKey="Engelke W" first="Wilfried" last="Engelke">Wilfried Engelke</name><affiliation><nlm:aff id="au2"><institution>Department of Oral and Maxillofacial Surgery, Georg-August-University Hospital</institution><addr-line>Göttingen, Germany</addr-line></nlm:aff></affiliation></author></analytic><series><title level="j">International Journal of Clinical and Experimental Medicine</title><idno type="eISSN">1940-5901</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>To assess bone augmentation based on a non-critical defect, 1.5 mm deep cobalt-chromium (Co-Cr) barrier membranes were placed on seven adult California rabbits with three different grafting situations: whole blood, whole blood with tricalcium phosphate (TCP), and TCP mixed with bone marrow cells. Macroscopic assessment of the animals was performed once a week and densitometric studies were performed once a month. Three months post-surgery, after detaching the membranes, tibias were sectioned and followed the routine laboratory processing for decalcified sections, with inclusion in paraffin and staining by hematoxylin and eosin technique. Bone augmentation was observed for each animal, even sometimes over the Co-Cr membranes. Compact bone was mostly observed for every situation, with a higher cellular activity on those samples with bone grafts. This could be due to the presence of graft remains at the growth area. It could be concluded that blood supply to the site providing growth factors by the blood clot formation, and the placement of an osteoconductive non-resolvable membrane that favors osseoinduction, may be sufficient elements to achieve bone augmentation in a period of three months in rabbit tibia.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Int J Clin Exp Med</journal-id><journal-id journal-id-type="iso-abbrev">Int J Clin Exp Med</journal-id><journal-id journal-id-type="publisher-id">ijcem</journal-id><journal-title-group><journal-title>International Journal of Clinical and Experimental Medicine</journal-title></journal-title-group><issn pub-type="epub">1940-5901</issn><publisher><publisher-name>e-Century Publishing Corporation</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">25784982</article-id><article-id pub-id-type="pmc">4358437</article-id><article-categories><subj-group subj-group-type="heading"><subject>Original Article</subject></subj-group></article-categories><title-group><article-title>Bone augmentation in rabbit tibia using microfixed cobalt-chromium membranes with whole blood, tricalcium phosphate and bone marrow cells</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Decco</surname><given-names>Oscar</given-names></name><xref ref-type="aff" rid="au1">1</xref></contrib><contrib contrib-type="author"><name><surname>Cura</surname><given-names>Andrea</given-names></name><xref ref-type="aff" rid="au1">1</xref></contrib><contrib contrib-type="author"><name><surname>Beltrán</surname><given-names>Víctor</given-names></name><xref ref-type="aff" rid="au2">2</xref><xref ref-type="aff" rid="au3">3</xref></contrib><contrib contrib-type="author"><name><surname>Lezcano</surname><given-names>María</given-names></name><xref ref-type="aff" rid="au1">1</xref></contrib><contrib contrib-type="author"><name><surname>Engelke</surname><given-names>Wilfried</given-names></name><xref ref-type="aff" rid="au2">2</xref></contrib><aff id="au1"><label>1</label><institution>Department of Bioengineering, Faculty of Engineering, Universidad Nacional de Entre Rios</institution><addr-line>Argentina</addr-line></aff><aff id="au2"><label>2</label><institution>Department of Oral and Maxillofacial Surgery, Georg-August-University Hospital</institution><addr-line>Göttingen, Germany</addr-line></aff><aff id="au3"><label>3</label><institution>CIMOFIR Research Center, Faculty of Dentistry, Universidad de La Frontera</institution><addr-line>Temuco, Chile</addr-line></aff></contrib-group><author-notes><corresp><bold>Address correspondence to:</bold> Dr. Oscar Decco, Department of Bioengineering, Faculty of Engineering, Universidad Nacional de Entre Rios, Argentina, Ruta Prov, 11 Km, 10, 3100 Oro Verde (Paraná)-Entre Ríos, Argentina. E-mail: <email>odecco@bioimplantes.com.ar</email>; <email>victor.beltran@ufrontera.cl</email></corresp></author-notes><pub-date pub-type="collection"><year>2015</year></pub-date><pub-date pub-type="epub"><day>15</day><month>1</month><year>2015</year></pub-date><volume>8</volume><issue>1</issue><fpage>135</fpage><lpage>144</lpage><history><date date-type="received"><day>22</day><month>10</month><year>2014</year></date><date date-type="accepted"><day>07</day><month>1</month><year>2015</year></date></history><permissions><copyright-statement>IJCEM Copyright © 2015</copyright-statement><copyright-year>2015</copyright-year></permissions><abstract><p>To assess bone augmentation based on a non-critical defect, 1.5 mm deep cobalt-chromium (Co-Cr) barrier membranes were placed on seven adult California rabbits with three different grafting situations: whole blood, whole blood with tricalcium phosphate (TCP), and TCP mixed with bone marrow cells. Macroscopic assessment of the animals was performed once a week and densitometric studies were performed once a month. Three months post-surgery, after detaching the membranes, tibias were sectioned and followed the routine laboratory processing for decalcified sections, with inclusion in paraffin and staining by hematoxylin and eosin technique. Bone augmentation was observed for each animal, even sometimes over the Co-Cr membranes. Compact bone was mostly observed for every situation, with a higher cellular activity on those samples with bone grafts. This could be due to the presence of graft remains at the growth area. It could be concluded that blood supply to the site providing growth factors by the blood clot formation, and the placement of an osteoconductive non-resolvable membrane that favors osseoinduction, may be sufficient elements to achieve bone augmentation in a period of three months in rabbit tibia.</p></abstract><kwd-group><kwd>Bone augmentation</kwd><kwd>cobalt-chromium</kwd><kwd>bone marrow cells</kwd><kwd>tricalcium phosphate</kwd></kwd-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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