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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">The Effect of <italic>Astragalus</italic>
Extractive on Alveolar Bone Rebuilding Progress of Tooth Extracted Socket of Ovariectomied Rats</title>
<author><name sortKey="Liu, Xiaochen" sort="Liu, Xiaochen" uniqKey="Liu X" first="Xiaochen" last="Liu">Xiaochen Liu</name>
<affiliation><nlm:aff id="A1"> Stomatology Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Zhang, Runju" sort="Zhang, Runju" uniqKey="Zhang R" first="Runju" last="Zhang">Runju Zhang</name>
<affiliation><nlm:aff id="A2">Women's Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Zhou, Yi" sort="Zhou, Yi" uniqKey="Zhou Y" first="Yi" last="Zhou">Yi Zhou</name>
<affiliation><nlm:aff id="A1"> Stomatology Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Yang, Yanli" sort="Yang, Yanli" uniqKey="Yang Y" first="Yanli" last="Yang">Yanli Yang</name>
<affiliation><nlm:aff id="A1"> Stomatology Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Si, Hongling" sort="Si, Hongling" uniqKey="Si H" first="Hongling" last="Si">Hongling Si</name>
<affiliation><nlm:aff id="A3">Stomatology Hospital?Xian Jiaotong University, Xian, Shaanxi, China</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Li, Xiaohong" sort="Li, Xiaohong" uniqKey="Li X" first="Xiaohong" last="Li">Xiaohong Li</name>
<affiliation><nlm:aff id="A3">Stomatology Hospital?Xian Jiaotong University, Xian, Shaanxi, China</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Liu, Li" sort="Liu, Li" uniqKey="Liu L" first="Li" last="Liu">Li Liu</name>
<affiliation><nlm:aff id="A1"> Stomatology Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China</nlm:aff>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">25395711</idno>
<idno type="pmc">4202524</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4202524</idno>
<idno type="RBID">PMC:4202524</idno>
<date when="2014">2014</date>
<idno type="wicri:Area/Pmc/Corpus">002234</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002234</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">The Effect of <italic>Astragalus</italic>
Extractive on Alveolar Bone Rebuilding Progress of Tooth Extracted Socket of Ovariectomied Rats</title>
<author><name sortKey="Liu, Xiaochen" sort="Liu, Xiaochen" uniqKey="Liu X" first="Xiaochen" last="Liu">Xiaochen Liu</name>
<affiliation><nlm:aff id="A1"> Stomatology Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Zhang, Runju" sort="Zhang, Runju" uniqKey="Zhang R" first="Runju" last="Zhang">Runju Zhang</name>
<affiliation><nlm:aff id="A2">Women's Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Zhou, Yi" sort="Zhou, Yi" uniqKey="Zhou Y" first="Yi" last="Zhou">Yi Zhou</name>
<affiliation><nlm:aff id="A1"> Stomatology Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Yang, Yanli" sort="Yang, Yanli" uniqKey="Yang Y" first="Yanli" last="Yang">Yanli Yang</name>
<affiliation><nlm:aff id="A1"> Stomatology Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Si, Hongling" sort="Si, Hongling" uniqKey="Si H" first="Hongling" last="Si">Hongling Si</name>
<affiliation><nlm:aff id="A3">Stomatology Hospital?Xian Jiaotong University, Xian, Shaanxi, China</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Li, Xiaohong" sort="Li, Xiaohong" uniqKey="Li X" first="Xiaohong" last="Li">Xiaohong Li</name>
<affiliation><nlm:aff id="A3">Stomatology Hospital?Xian Jiaotong University, Xian, Shaanxi, China</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Liu, Li" sort="Liu, Li" uniqKey="Liu L" first="Li" last="Liu">Li Liu</name>
<affiliation><nlm:aff id="A1"> Stomatology Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China</nlm:aff>
</affiliation>
</author>
</analytic>
<series><title level="j">African Journal of Traditional, Complementary, and Alternative Medicines</title>
<idno type="eISSN">0189-6016</idno>
<imprint><date when="2014">2014</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><sec><title>Background</title>
<p>Postmenopausal osteoporosis (PMO) is an estrogen deficiency condition that causes severe loss of bone mass in the vertebrae and long bones. We explored the effect and the possible underlying mechanism of the extracts of <italic>Astragalus</italic>
(AE) on the tooth alveolar bone rebuilding progress of postmenopausal osteoporosis of PMO animal models.</p>
</sec>
<sec sec-type="materials|methods"><title>Material and methods</title>
<p>The PMO models were acquired by ovariectomy. After 8 weeks the first left maxillary molars of the rats were extracted and AE was administered orally for 8 weeks. Then the histological morphology and the transcription and expression of TGF-β1 and TNF-α in the tooth extracted socket were detected by HE dying, QRT-PCR and ELISA.</p>
</sec>
<sec sec-type="results"><title>Results</title>
<p>The results showed that the new bone volume and TGF-β1 was significantly lower in PMO group than the control group and AE group at the observing period. At the same time TNF-α in PMO group was significantly higher than the other two groups. Moreover AE group had no significant differences with the control group in all data at the observing period.</p>
</sec>
<sec sec-type="conclusion"><title>Conclusion</title>
<p>AE has positive effect on alveolar bone rebuilding progress of tooth extracted socket of PMO rats. AE also has the potential to enhance the expression of TGF-β1 and decrease the expression of TNF-α of the rebuilding tooth extracted socket.</p>
</sec>
</div>
</front>
</TEI>
<pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Afr J Tradit Complement Altern Med</journal-id>
<journal-id journal-id-type="iso-abbrev">Afr J Tradit Complement Altern Med</journal-id>
<journal-title-group><journal-title>African Journal of Traditional, Complementary, and Alternative Medicines</journal-title>
</journal-title-group>
<issn pub-type="epub">0189-6016</issn>
<publisher><publisher-name>African Networks on Ethnomedicines</publisher-name>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">25395711</article-id>
<article-id pub-id-type="pmc">4202524</article-id>
<article-id pub-id-type="publisher-id">jAJT.v11.i5.pg91</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Short Communications</subject>
</subj-group>
</article-categories>
<title-group><article-title>The Effect of <italic>Astragalus</italic>
Extractive on Alveolar Bone Rebuilding Progress of Tooth Extracted Socket of Ovariectomied Rats</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Liu</surname>
<given-names>Xiaochen</given-names>
</name>
<xref ref-type="aff" rid="A1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Zhang</surname>
<given-names>Runju</given-names>
</name>
<xref ref-type="aff" rid="A2">2</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Zhou</surname>
<given-names>Yi</given-names>
</name>
<xref ref-type="aff" rid="A1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Yang</surname>
<given-names>Yanli</given-names>
</name>
<xref ref-type="aff" rid="A1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Si</surname>
<given-names>Hongling</given-names>
</name>
<xref ref-type="aff" rid="A3">3</xref>
</contrib>
<contrib contrib-type="author" corresp="yes"><name><surname>Li</surname>
<given-names>Xiaohong</given-names>
</name>
<xref ref-type="aff" rid="A3">3</xref>
</contrib>
<contrib contrib-type="author" corresp="yes"><name><surname>Liu</surname>
<given-names>Li</given-names>
</name>
<xref ref-type="aff" rid="A1">1</xref>
</contrib>
</contrib-group>
<aff id="A1"><label>1</label>
Stomatology Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China</aff>
<aff id="A2"><label>2</label>
Women's Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China</aff>
<aff id="A3"><label>3</label>
Stomatology Hospital?Xian Jiaotong University, Xian, Shaanxi, China</aff>
<author-notes><corresp>*<email>denv132@163.com</email>
</corresp>
</author-notes>
<pub-date pub-type="epub"><day>23</day>
<month>8</month>
<year>2014</year>
</pub-date>
<pub-date pub-type="collection"><year>2014</year>
</pub-date>
<volume>11</volume>
<issue>5</issue>
<fpage>91</fpage>
<lpage>98</lpage>
<permissions><copyright-statement>Copyright © Afr. J. Traditional Complementary and Alternative Medicines 2014</copyright-statement>
<copyright-year>2014</copyright-year>
</permissions>
<abstract abstract-type="executive-summary"><sec><title>Background</title>
<p>Postmenopausal osteoporosis (PMO) is an estrogen deficiency condition that causes severe loss of bone mass in the vertebrae and long bones. We explored the effect and the possible underlying mechanism of the extracts of <italic>Astragalus</italic>
(AE) on the tooth alveolar bone rebuilding progress of postmenopausal osteoporosis of PMO animal models.</p>
</sec>
<sec sec-type="materials|methods"><title>Material and methods</title>
<p>The PMO models were acquired by ovariectomy. After 8 weeks the first left maxillary molars of the rats were extracted and AE was administered orally for 8 weeks. Then the histological morphology and the transcription and expression of TGF-β1 and TNF-α in the tooth extracted socket were detected by HE dying, QRT-PCR and ELISA.</p>
</sec>
<sec sec-type="results"><title>Results</title>
<p>The results showed that the new bone volume and TGF-β1 was significantly lower in PMO group than the control group and AE group at the observing period. At the same time TNF-α in PMO group was significantly higher than the other two groups. Moreover AE group had no significant differences with the control group in all data at the observing period.</p>
</sec>
<sec sec-type="conclusion"><title>Conclusion</title>
<p>AE has positive effect on alveolar bone rebuilding progress of tooth extracted socket of PMO rats. AE also has the potential to enhance the expression of TGF-β1 and decrease the expression of TNF-α of the rebuilding tooth extracted socket.</p>
</sec>
</abstract>
<kwd-group><kwd>PMO</kwd>
<kwd>TGF-β1</kwd>
<kwd>TNF-α</kwd>
<kwd><italic>Astragalus</italic>
</kwd>
</kwd-group>
</article-meta>
</front>
</pmc>
</record>
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