Three-Dimensional Evaluation of Mandibular Bone Regenerated By Bone Transport Distraction Osteogenesis
Identifieur interne : 002155 ( Pmc/Corpus ); précédent : 002154; suivant : 002156Three-Dimensional Evaluation of Mandibular Bone Regenerated By Bone Transport Distraction Osteogenesis
Auteurs : Elias Kontogiorgos ; Mohammed E. Elsalanty ; Uriel Zapata ; Ibrahim Zakhary ; William W. Nagy ; Paul C. Dechow ; Lynne A. OppermanSource :
- Calcified tissue international [ 0171-967X ] ; 2011.
Abstract
The purpose of this study was to evaluate the structure and material properties of native mandibular bone and those of early regenerate bone, produced by bone transport distraction osteogenesis. Ten adult foxhounds were divided into two groups of five animals each. In all animals, a 3- to 4-cm defect was created on one side of the mandible. A bone transport reconstruction plate, consisting of a reconstruction plate with an attached intraoral transport unit, was utilized to stabilize the mandible and regenerate bone at a rate of 1 mm/day. After the distraction period was finished, the animals were killed at 6 and 12 weeks of consolidation. Micro-computed tomography was used to assess the morphometric and structural indices of regenerate bone and matching bone from the unoperated contralateral side. Significant new bone was formed within the defect in the 6- and 12-week groups. Significant differences (
Url:
DOI: 10.1007/s00223-011-9492-2
PubMed: 21556698
PubMed Central: 3133632
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<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">7905481</journal-id><journal-id journal-id-type="pubmed-jr-id">2713</journal-id><journal-id journal-id-type="nlm-ta">Calcif Tissue Int</journal-id><journal-title-group><journal-title>Calcified tissue international</journal-title></journal-title-group><issn pub-type="ppub">0171-967X</issn><issn pub-type="epub">1432-0827</issn></journal-meta><article-meta><article-id pub-id-type="pmid">21556698</article-id><article-id pub-id-type="pmc">3133632</article-id><article-id pub-id-type="doi">10.1007/s00223-011-9492-2</article-id><article-id pub-id-type="manuscript">NIHMS301335</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Three-Dimensional Evaluation of Mandibular Bone Regenerated By Bone Transport Distraction Osteogenesis</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Kontogiorgos</surname><given-names>Elias</given-names></name><aff id="A1">Department of Biomedical Sciences, Texas A&M Health Science Center, Baylor College of Dentistry, 3302 Gaston Avenue, Dallas, TX 75246, USA</aff><email>ekontogiorgos@bcd.tamhsc.edu</email></contrib><contrib contrib-type="author"><name><surname>Elsalanty</surname><given-names>Mohammed E.</given-names></name><aff id="A2">Department of Oral Biology, School of Dentistry, Georgia Health Science University, Augusta, GA, USA</aff><email>melsalanty@georgiahealth.edu</email></contrib><contrib contrib-type="author"><name><surname>Zapata</surname><given-names>Uriel</given-names></name><aff id="A3">Department of Biomedical Sciences, Texas A&M Health Science Center, Baylor College of Dentistry, 3302 Gaston Avenue, Dallas, TX 75246, USA</aff><email>uzapata@eafit.edu.co</email></contrib><contrib contrib-type="author"><name><surname>Zakhary</surname><given-names>Ibrahim</given-names></name><aff id="A4">Department of Oral Biology, School of Dentistry, Georgia Health Science University, Augusta, GA, USA</aff><email>izakhary@georgiahealth.edu</email></contrib><contrib contrib-type="author"><name><surname>Nagy</surname><given-names>William W.</given-names></name><aff id="A5">Department of Restorative Sciences, Texas A&M Health Science Center, Baylor College of Dentistry, Dallas, TX, USA</aff><email>wnagy@bcd.tamhsc.edu</email></contrib><contrib contrib-type="author"><name><surname>Dechow</surname><given-names>Paul C.</given-names></name><aff id="A6">Department of Biomedical Sciences, Texas A&M Health Science Center, Baylor College of Dentistry, 3302 Gaston Avenue, Dallas, TX 75246, USA</aff><email>pdechow@bcd.tamhsc.edu</email></contrib><contrib contrib-type="author"><name><surname>Opperman</surname><given-names>Lynne A.</given-names></name><aff id="A7">Department of Biomedical Sciences, Texas A&M Health Science Center, Baylor College of Dentistry, 3302 Gaston Avenue, Dallas, TX 75246, USA</aff><email>lopperman@bcd.tamhsc.edu</email></contrib></contrib-group><author-notes><fn id="FN1" fn-type="present-address"><p><italic>Present Address:</italic> U. Zapata, Departamento de Ingeniería Mecánica, Universidad Eafit, Carrera 49 No 7 Sur - 50, Medellin, Colombia</p></fn></author-notes><pub-date pub-type="nihms-submitted"><day>6</day><month>6</month><year>2011</year></pub-date><pub-date pub-type="epub"><day>10</day><month>5</month><year>2011</year></pub-date><pub-date pub-type="ppub"><month>7</month><year>2011</year></pub-date><pub-date pub-type="pmc-release"><day>1</day><month>7</month><year>2012</year></pub-date><volume>89</volume><issue>1</issue><fpage>43</fpage><lpage>52</lpage><permissions><copyright-statement>© Springer Science+Business Media, LLC 2011</copyright-statement><copyright-year>2011</copyright-year></permissions><abstract><p id="P1">The purpose of this study was to evaluate the structure and material properties of native mandibular bone and those of early regenerate bone, produced by bone transport distraction osteogenesis. Ten adult foxhounds were divided into two groups of five animals each. In all animals, a 3- to 4-cm defect was created on one side of the mandible. A bone transport reconstruction plate, consisting of a reconstruction plate with an attached intraoral transport unit, was utilized to stabilize the mandible and regenerate bone at a rate of 1 mm/day. After the distraction period was finished, the animals were killed at 6 and 12 weeks of consolidation. Micro-computed tomography was used to assess the morphometric and structural indices of regenerate bone and matching bone from the unoperated contralateral side. Significant new bone was formed within the defect in the 6- and 12-week groups. Significant differences (<italic>P</italic> ≤ 0.05) between mandibular regenerated and native bone were found in regard to bone volume fraction, mineral density, bone surface ratio, trabecular thickness, trabecular separation, and connectivity density, which increased from 12 to 18 weeks of consolidation. We showed that regenerated bone is still mineralizing and that native bone appears denser because of a thick outer layer of cortical bone that is not yet formed in the regenerate. However, the regenerate showed a significantly higher number of thicker trabeculae.</p></abstract><kwd-group><kwd>Micro-computed tomography</kwd><kwd>Distraction device</kwd><kwd>Bone transport</kwd><kwd>Bone regeneration</kwd></kwd-group><funding-group><award-group><funding-source country="United States">National Institute of Dental and Craniofacial Research : NIDCR</funding-source><award-id>R42 DE015437-03 || DE</award-id></award-group><award-group><funding-source country="United States">National Institute of Dental and Craniofacial Research : NIDCR</funding-source><award-id>R42 DE015437-02 || DE</award-id></award-group><award-group><funding-source country="United States">National Institute of Dental and Craniofacial Research : NIDCR</funding-source><award-id>R41 DE015437-01 || DE</award-id></award-group></funding-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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