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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Serum 25(OH)-Vitamin D concentration and risk of esophageal squamous dysplasia</title><author><name sortKey="Abnet, Christian C" sort="Abnet, Christian C" uniqKey="Abnet C" first="Christian C." last="Abnet">Christian C. Abnet</name><affiliation><nlm:aff id="A1">Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, Unites States of America</nlm:aff></affiliation></author><author><name sortKey="Chen, Wen" sort="Chen, Wen" uniqKey="Chen W" first="Wen" last="Chen">Wen Chen</name><affiliation><nlm:aff id="A2">Cancer Institute (Hospital), Chinese Academy of Medical Sciences, Beijing, People’s Republic of China</nlm:aff></affiliation></author><author><name sortKey="Dawsey, Sanford M" sort="Dawsey, Sanford M" uniqKey="Dawsey S" first="Sanford M." last="Dawsey">Sanford M. Dawsey</name><affiliation><nlm:aff id="A1">Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, Unites States of America</nlm:aff></affiliation></author><author><name sortKey="Wei, Wen Qiang" sort="Wei, Wen Qiang" uniqKey="Wei W" first="Wen-Qiang" last="Wei">Wen-Qiang Wei</name><affiliation><nlm:aff id="A2">Cancer Institute (Hospital), Chinese Academy of Medical Sciences, Beijing, People’s Republic of China</nlm:aff></affiliation></author><author><name sortKey="Roth, Mark J" sort="Roth, Mark J" uniqKey="Roth M" first="Mark J." last="Roth">Mark J. Roth</name><affiliation><nlm:aff id="A1">Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, Unites States of America</nlm:aff></affiliation></author><author><name sortKey="Liu, Bing" sort="Liu, Bing" uniqKey="Liu B" first="Bing" last="Liu">Bing Liu</name><affiliation><nlm:aff id="A2">Cancer Institute (Hospital), Chinese Academy of Medical Sciences, Beijing, People’s Republic of China</nlm:aff></affiliation></author><author><name sortKey="Lu, Ning" sort="Lu, Ning" uniqKey="Lu N" first="Ning" last="Lu">Ning Lu</name><affiliation><nlm:aff id="A2">Cancer Institute (Hospital), Chinese Academy of Medical Sciences, Beijing, People’s Republic of China</nlm:aff></affiliation></author><author><name sortKey="Taylor, Philip R" sort="Taylor, Philip R" uniqKey="Taylor P" first="Philip R." last="Taylor">Philip R. Taylor</name><affiliation><nlm:aff id="A1">Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, Unites States of America</nlm:aff></affiliation></author><author><name sortKey="Qiao, You Lin" sort="Qiao, You Lin" uniqKey="Qiao Y" first="You-Lin" last="Qiao">You-Lin Qiao</name><affiliation><nlm:aff id="A2">Cancer Institute (Hospital), Chinese Academy of Medical Sciences, Beijing, People’s Republic of China</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">17855710</idno><idno type="pmc">2812415</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2812415</idno><idno type="RBID">PMC:2812415</idno><idno type="doi">10.1158/1055-9965.EPI-07-0461</idno><date when="2007">2007</date><idno type="wicri:Area/Pmc/Corpus">002133</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002133</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Serum 25(OH)-Vitamin D concentration and risk of esophageal squamous dysplasia</title><author><name sortKey="Abnet, Christian C" sort="Abnet, Christian C" uniqKey="Abnet C" first="Christian C." last="Abnet">Christian C. Abnet</name><affiliation><nlm:aff id="A1">Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, Unites States of America</nlm:aff></affiliation></author><author><name sortKey="Chen, Wen" sort="Chen, Wen" uniqKey="Chen W" first="Wen" last="Chen">Wen Chen</name><affiliation><nlm:aff id="A2">Cancer Institute (Hospital), Chinese Academy of Medical Sciences, Beijing, People’s Republic of China</nlm:aff></affiliation></author><author><name sortKey="Dawsey, Sanford M" sort="Dawsey, Sanford M" uniqKey="Dawsey S" first="Sanford M." last="Dawsey">Sanford M. Dawsey</name><affiliation><nlm:aff id="A1">Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, Unites States of America</nlm:aff></affiliation></author><author><name sortKey="Wei, Wen Qiang" sort="Wei, Wen Qiang" uniqKey="Wei W" first="Wen-Qiang" last="Wei">Wen-Qiang Wei</name><affiliation><nlm:aff id="A2">Cancer Institute (Hospital), Chinese Academy of Medical Sciences, Beijing, People’s Republic of China</nlm:aff></affiliation></author><author><name sortKey="Roth, Mark J" sort="Roth, Mark J" uniqKey="Roth M" first="Mark J." last="Roth">Mark J. Roth</name><affiliation><nlm:aff id="A1">Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, Unites States of America</nlm:aff></affiliation></author><author><name sortKey="Liu, Bing" sort="Liu, Bing" uniqKey="Liu B" first="Bing" last="Liu">Bing Liu</name><affiliation><nlm:aff id="A2">Cancer Institute (Hospital), Chinese Academy of Medical Sciences, Beijing, People’s Republic of China</nlm:aff></affiliation></author><author><name sortKey="Lu, Ning" sort="Lu, Ning" uniqKey="Lu N" first="Ning" last="Lu">Ning Lu</name><affiliation><nlm:aff id="A2">Cancer Institute (Hospital), Chinese Academy of Medical Sciences, Beijing, People’s Republic of China</nlm:aff></affiliation></author><author><name sortKey="Taylor, Philip R" sort="Taylor, Philip R" uniqKey="Taylor P" first="Philip R." last="Taylor">Philip R. Taylor</name><affiliation><nlm:aff id="A1">Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, Unites States of America</nlm:aff></affiliation></author><author><name sortKey="Qiao, You Lin" sort="Qiao, You Lin" uniqKey="Qiao Y" first="You-Lin" last="Qiao">You-Lin Qiao</name><affiliation><nlm:aff id="A2">Cancer Institute (Hospital), Chinese Academy of Medical Sciences, Beijing, People’s Republic of China</nlm:aff></affiliation></author></analytic><series><title level="j">Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology</title><idno type="ISSN">1055-9965</idno><idno type="eISSN">1538-7755</idno><imprint><date when="2007">2007</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="S1"><title>Background</title><p id="P1">Squamous dysplasia is the precursor lesion for esophageal squamous cell carcinoma (ESCC), and nutritional factors play an important role in the etiology of this cancer. Previous studies using a variety of measures of vitamin D exposure have reached different conclusions about the association between vitamin D and risk of developing esophageal cancer.</p></sec><sec sec-type="methods" id="S2"><title>Methods</title><p id="P2">We measured serum 25-hydroxyvitamin D (25(OH)D) concentrations in a cross-sectional analysis of 720 subjects from Linxian, China, a population at high risk for developing ESCC. All subjects underwent endoscopy and biopsy and were categorized by presence or absence of histologic squamous dysplasia. We used crude and multivariate adjusted generalized linear models to estimate the relative risk (RR) and 95% confidence intervals (CI) for the association between squamous dysplasia and sex-specific quartiles of serum 25(OH)D concentration.</p></sec><sec id="S3"><title>Results</title><p id="P3">Two hundred and thirty (32%) of 720 subjects had squamous dysplasia. Subjects with dysplasia had significantly higher median serum 25(OH)D concentrations then subjects without dysplasia, 36.5 and 31.5 nmol/L respectively (Wilcoxon two-sample test <italic>p</italic> = 0.0004). In multivariate adjusted models, subjects in the highest compared to the lowest quartile were at significantly increased risk of squamous dysplasia, RR (95% CI) = 1.86 (1.35–2.62). Increased risks were similar when examined in men and women separately: Men RR (95% CI) = 1.74 (1.08–2.93); Women RR (95% CI) = 1.96 (1.28–3.18).</p></sec><sec id="S4"><title>Conclusions</title><p id="P4">Higher serum 25(OH)D concentration was associated with significantly increased risk of squamous dysplasia. No obvious source of measured or unmeasured confounding explains this finding.</p></sec></div></front></TEI><pmc article-type="research-article" xml:lang="EN"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
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<front><journal-meta><journal-id journal-id-type="nlm-journal-id">9200608</journal-id><journal-id journal-id-type="pubmed-jr-id">2299</journal-id><journal-id journal-id-type="nlm-ta">Cancer Epidemiol Biomarkers Prev</journal-id><journal-title>Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology</journal-title><issn pub-type="ppub">1055-9965</issn><issn pub-type="epub">1538-7755</issn></journal-meta><article-meta><article-id pub-id-type="pmid">17855710</article-id><article-id pub-id-type="pmc">2812415</article-id><article-id pub-id-type="doi">10.1158/1055-9965.EPI-07-0461</article-id><article-id pub-id-type="manuscript">NIHMS159689</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Serum 25(OH)-Vitamin D concentration and risk of esophageal squamous dysplasia</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Abnet</surname><given-names>Christian C.</given-names></name><xref ref-type="aff" rid="A1">1</xref><xref ref-type="corresp" rid="cor1">*</xref></contrib><contrib contrib-type="author"><name><surname>Chen</surname><given-names>Wen</given-names></name><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Dawsey</surname><given-names>Sanford M.</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Wei</surname><given-names>Wen-Qiang</given-names></name><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Roth</surname><given-names>Mark J.</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Liu</surname><given-names>Bing</given-names></name><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Lu</surname><given-names>Ning</given-names></name><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Taylor</surname><given-names>Philip R.</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Qiao</surname><given-names>You-Lin</given-names></name><xref ref-type="aff" rid="A2">2</xref><xref ref-type="corresp" rid="cor1">*</xref></contrib></contrib-group><aff id="A1"><label>1</label>Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, Unites States of America</aff><aff id="A2"><label>2</label>Cancer Institute (Hospital), Chinese Academy of Medical Sciences, Beijing, People’s Republic of China</aff><author-notes><corresp id="cor1"><label>*</label><bold>Address for Correspondence</bold>: Christian Abnet, PhD, MPH, Investigator, Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, 6120 Executive Blvd, EPS/320, MSC 7232, Rockville, MD 20852, V: (301) 594-1511, F: (301) 496-6829, <email>abnetc@mail.nih.gov</email>, in China: Qiao You-Lin, MD, PhD, Department of Cancer Epidemiology, Cancer Institute, Chinese Academy of Medical Sciences, 17 S. Panjiayuan Lane, Chaoyang District, PO Box 2258, Beijing, 100021</corresp></author-notes><pub-date pub-type="nihms-submitted"><day>18</day><month>11</month><year>2009</year></pub-date><pub-date pub-type="ppub"><month>9</month><year>2007</year></pub-date><pub-date pub-type="pmc-release"><day>27</day><month>1</month><year>2010</year></pub-date><volume>16</volume><issue>9</issue><fpage>1889</fpage><lpage>1893</lpage><abstract><sec id="S1"><title>Background</title><p id="P1">Squamous dysplasia is the precursor lesion for esophageal squamous cell carcinoma (ESCC), and nutritional factors play an important role in the etiology of this cancer. Previous studies using a variety of measures of vitamin D exposure have reached different conclusions about the association between vitamin D and risk of developing esophageal cancer.</p></sec><sec sec-type="methods" id="S2"><title>Methods</title><p id="P2">We measured serum 25-hydroxyvitamin D (25(OH)D) concentrations in a cross-sectional analysis of 720 subjects from Linxian, China, a population at high risk for developing ESCC. All subjects underwent endoscopy and biopsy and were categorized by presence or absence of histologic squamous dysplasia. We used crude and multivariate adjusted generalized linear models to estimate the relative risk (RR) and 95% confidence intervals (CI) for the association between squamous dysplasia and sex-specific quartiles of serum 25(OH)D concentration.</p></sec><sec id="S3"><title>Results</title><p id="P3">Two hundred and thirty (32%) of 720 subjects had squamous dysplasia. Subjects with dysplasia had significantly higher median serum 25(OH)D concentrations then subjects without dysplasia, 36.5 and 31.5 nmol/L respectively (Wilcoxon two-sample test <italic>p</italic> = 0.0004). In multivariate adjusted models, subjects in the highest compared to the lowest quartile were at significantly increased risk of squamous dysplasia, RR (95% CI) = 1.86 (1.35–2.62). Increased risks were similar when examined in men and women separately: Men RR (95% CI) = 1.74 (1.08–2.93); Women RR (95% CI) = 1.96 (1.28–3.18).</p></sec><sec id="S4"><title>Conclusions</title><p id="P4">Higher serum 25(OH)D concentration was associated with significantly increased risk of squamous dysplasia. No obvious source of measured or unmeasured confounding explains this finding.</p></sec></abstract><kwd-group><kwd>Esophageal cancer</kwd><kwd>Squamous dysplasia</kwd><kwd>Vitamin D</kwd><kwd>Serum 25(OH)D</kwd><kwd>China</kwd></kwd-group><contract-num rid="CP1">ZIA CP000185-05
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