Transcriptional regulation of bone and joint remodeling by NFAT
Identifieur interne : 002109 ( Pmc/Corpus ); précédent : 002108; suivant : 002110Transcriptional regulation of bone and joint remodeling by NFAT
Auteurs : Despina Sitara ; Antonios O. AliprantisSource :
- Immunological reviews [ 0105-2896 ] ; 2010.
Abstract
Osteoporosis and arthritis are highly prevalent diseases and a significant cause of morbidity and mortality worldwide. These diseases result from aberrant tissue remodeling leading to weak, fracture-prone bones or painful, dysfunctional joints. The nuclear factor of activated T cells (NFAT) transcription factor family controls diverse biologic processes in vertebrates. Here, we review the scientific evidence that links NFAT-regulated gene transcription to bone and joint pathology. A particular emphasis is placed on the role of NFATs in bone resorption and formation by osteoclasts and osteoblasts, respectively. In addition, emerging data that connect NFATs with cartilage biology, angiogenesis, nociception, and neurogenic inflammation are explored. The goal of this article is to highlight the importance of tissue remodeling in musculoskeletal disease and situate NFAT-driven cellular responses within this context to inspire future research endeavors.
Url:
DOI: 10.1111/j.0105-2896.2009.00849.x
PubMed: 20193006
PubMed Central: 2904911
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PMC:2904911Le document en format XML
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<author><name sortKey="Aliprantis, Antonios O" sort="Aliprantis, Antonios O" uniqKey="Aliprantis A" first="Antonios O." last="Aliprantis">Antonios O. Aliprantis</name>
<affiliation><nlm:aff id="A1">Department of Infectious Diseases and Immunology, Harvard School of Public Health, Boston, MA, USA</nlm:aff>
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<affiliation><nlm:aff id="A2">Department of Medicine, Division of Rheumatology, Allergy and Immunology, Brigham and Women's Hospital and Harvard Medical School, Arthritis Center, Boston, MA, USA</nlm:aff>
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<front><div type="abstract" xml:lang="en"><title>Summary</title>
<p id="P1">Osteoporosis and arthritis are highly prevalent diseases and a significant cause of morbidity and mortality worldwide. These diseases result from aberrant tissue remodeling leading to weak, fracture-prone bones or painful, dysfunctional joints. The nuclear factor of activated T cells (NFAT) transcription factor family controls diverse biologic processes in vertebrates. Here, we review the scientific evidence that links NFAT-regulated gene transcription to bone and joint pathology. A particular emphasis is placed on the role of NFATs in bone resorption and formation by osteoclasts and osteoblasts, respectively. In addition, emerging data that connect NFATs with cartilage biology, angiogenesis, nociception, and neurogenic inflammation are explored. The goal of this article is to highlight the importance of tissue remodeling in musculoskeletal disease and situate NFAT-driven cellular responses within this context to inspire future research endeavors.</p>
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<contrib-group><contrib contrib-type="author"><name><surname>Sitara</surname>
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<contrib contrib-type="author"><name><surname>Aliprantis</surname>
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<aff id="A1"><label>1</label>
Department of Infectious Diseases and Immunology, Harvard School of Public Health, Boston, MA, USA</aff>
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Department of Medicine, Division of Rheumatology, Allergy and Immunology, Brigham and Women's Hospital and Harvard Medical School, Arthritis Center, Boston, MA, USA</aff>
<author-notes><corresp id="CR1"><bold>Corresponding Author:</bold>
Antonios O Aliprantis Harvard School of Public Health 651 Huntington Avenue, FXB 205 Boston, Massachusetts 02115, USA Tel.: +1 617 432 4867 Fax: +1 617 432 0084 <email>aaliprantis@partners.org</email>
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<year>2010</year>
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<year>2011</year>
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<volume>233</volume>
<issue>1</issue>
<fpage>286</fpage>
<lpage>300</lpage>
<abstract><title>Summary</title>
<p id="P1">Osteoporosis and arthritis are highly prevalent diseases and a significant cause of morbidity and mortality worldwide. These diseases result from aberrant tissue remodeling leading to weak, fracture-prone bones or painful, dysfunctional joints. The nuclear factor of activated T cells (NFAT) transcription factor family controls diverse biologic processes in vertebrates. Here, we review the scientific evidence that links NFAT-regulated gene transcription to bone and joint pathology. A particular emphasis is placed on the role of NFATs in bone resorption and formation by osteoclasts and osteoblasts, respectively. In addition, emerging data that connect NFATs with cartilage biology, angiogenesis, nociception, and neurogenic inflammation are explored. The goal of this article is to highlight the importance of tissue remodeling in musculoskeletal disease and situate NFAT-driven cellular responses within this context to inspire future research endeavors.</p>
</abstract>
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