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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Current developments in salivary diagnostics</title><author><name sortKey="Miller, Craig S" sort="Miller, Craig S" uniqKey="Miller C" first="Craig S" last="Miller">Craig S. Miller</name><affiliation><nlm:aff id="A1">Oral Medicine Section, MN 324, University of Kentucky College of Dentistry, 800 Rose Street, Lexington, KY 40536-0297, USA Tel.: +1 859 323 5598<email>cmiller@uky.edu</email></nlm:aff></affiliation></author><author><name sortKey="Foley, Joseph D" sort="Foley, Joseph D" uniqKey="Foley J" first="Joseph D" last="Foley">Joseph D. Foley</name><affiliation><nlm:aff id="A2">Gill Heart Institute, University of Kentucky, Lexington, KY, USA</nlm:aff></affiliation></author><author><name sortKey="Bailey, Alison L" sort="Bailey, Alison L" uniqKey="Bailey A" first="Alison L" last="Bailey">Alison L. Bailey</name><affiliation><nlm:aff id="A2">Gill Heart Institute, University of Kentucky, Lexington, KY, USA</nlm:aff></affiliation></author><author><name sortKey="Campell, Charles L" sort="Campell, Charles L" uniqKey="Campell C" first="Charles L" last="Campell">Charles L. Campell</name><affiliation><nlm:aff id="A2">Gill Heart Institute, University of Kentucky, Lexington, KY, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A3">Lexington Veterans Administration Hospital, Lexington, KY, USA</nlm:aff></affiliation></author><author><name sortKey="Humphries, Roger L" sort="Humphries, Roger L" uniqKey="Humphries R" first="Roger L" last="Humphries">Roger L. Humphries</name><affiliation><nlm:aff id="A2">Gill Heart Institute, University of Kentucky, Lexington, KY, USA</nlm:aff></affiliation></author><author><name sortKey="Christodoulides, Nicolaos" sort="Christodoulides, Nicolaos" uniqKey="Christodoulides N" first="Nicolaos" last="Christodoulides">Nicolaos Christodoulides</name><affiliation><nlm:aff id="A4">Bioengineering & Chemistry, Rice University, Houston, TX, USA</nlm:aff></affiliation></author><author><name sortKey="Floriano, Pierre N" sort="Floriano, Pierre N" uniqKey="Floriano P" first="Pierre N" last="Floriano">Pierre N. Floriano</name><affiliation><nlm:aff id="A4">Bioengineering & Chemistry, Rice University, Houston, TX, USA</nlm:aff></affiliation></author><author><name sortKey="Simmons, Glennon" sort="Simmons, Glennon" uniqKey="Simmons G" first="Glennon" last="Simmons">Glennon Simmons</name><affiliation><nlm:aff id="A4">Bioengineering & Chemistry, Rice University, Houston, TX, USA</nlm:aff></affiliation></author><author><name sortKey="Bhagwandin, Bryon" sort="Bhagwandin, Bryon" uniqKey="Bhagwandin B" first="Bryon" last="Bhagwandin">Bryon Bhagwandin</name><affiliation><nlm:aff id="A5">LabNow Inc., Austin, TX, USA</nlm:aff></affiliation></author><author><name sortKey="Jacobson, James W" sort="Jacobson, James W" uniqKey="Jacobson J" first="James W" last="Jacobson">James W. Jacobson</name><affiliation><nlm:aff id="A5">LabNow Inc., Austin, TX, USA</nlm:aff></affiliation></author><author><name sortKey="Redding, Spencer W" sort="Redding, Spencer W" uniqKey="Redding S" first="Spencer W" last="Redding">Spencer W. Redding</name><affiliation><nlm:aff id="A6">Department of Dental Diagnostic Sciences, University of Texas, San Antonio, TX, USA</nlm:aff></affiliation></author><author><name sortKey="Ebersole, Jeffrey L" sort="Ebersole, Jeffrey L" uniqKey="Ebersole J" first="Jeffrey L" last="Ebersole">Jeffrey L. Ebersole</name><affiliation><nlm:aff id="A1">Oral Medicine Section, MN 324, University of Kentucky College of Dentistry, 800 Rose Street, Lexington, KY 40536-0297, USA Tel.: +1 859 323 5598<email>cmiller@uky.edu</email></nlm:aff></affiliation></author><author><name sortKey="Mcdevitt, John T" sort="Mcdevitt, John T" uniqKey="Mcdevitt J" first="John T" last="Mcdevitt">John T. Mcdevitt</name><affiliation><nlm:aff id="A4">Bioengineering & Chemistry, Rice University, Houston, TX, USA</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">20387312</idno><idno type="pmc">2857781</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2857781</idno><idno type="RBID">PMC:2857781</idno><date when="2010">2010</date><idno type="wicri:Area/Pmc/Corpus">002098</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002098</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Current developments in salivary diagnostics</title><author><name sortKey="Miller, Craig S" sort="Miller, Craig S" uniqKey="Miller C" first="Craig S" last="Miller">Craig S. Miller</name><affiliation><nlm:aff id="A1">Oral Medicine Section, MN 324, University of Kentucky College of Dentistry, 800 Rose Street, Lexington, KY 40536-0297, USA Tel.: +1 859 323 5598<email>cmiller@uky.edu</email></nlm:aff></affiliation></author><author><name sortKey="Foley, Joseph D" sort="Foley, Joseph D" uniqKey="Foley J" first="Joseph D" last="Foley">Joseph D. Foley</name><affiliation><nlm:aff id="A2">Gill Heart Institute, University of Kentucky, Lexington, KY, USA</nlm:aff></affiliation></author><author><name sortKey="Bailey, Alison L" sort="Bailey, Alison L" uniqKey="Bailey A" first="Alison L" last="Bailey">Alison L. Bailey</name><affiliation><nlm:aff id="A2">Gill Heart Institute, University of Kentucky, Lexington, KY, USA</nlm:aff></affiliation></author><author><name sortKey="Campell, Charles L" sort="Campell, Charles L" uniqKey="Campell C" first="Charles L" last="Campell">Charles L. Campell</name><affiliation><nlm:aff id="A2">Gill Heart Institute, University of Kentucky, Lexington, KY, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A3">Lexington Veterans Administration Hospital, Lexington, KY, USA</nlm:aff></affiliation></author><author><name sortKey="Humphries, Roger L" sort="Humphries, Roger L" uniqKey="Humphries R" first="Roger L" last="Humphries">Roger L. Humphries</name><affiliation><nlm:aff id="A2">Gill Heart Institute, University of Kentucky, Lexington, KY, USA</nlm:aff></affiliation></author><author><name sortKey="Christodoulides, Nicolaos" sort="Christodoulides, Nicolaos" uniqKey="Christodoulides N" first="Nicolaos" last="Christodoulides">Nicolaos Christodoulides</name><affiliation><nlm:aff id="A4">Bioengineering & Chemistry, Rice University, Houston, TX, USA</nlm:aff></affiliation></author><author><name sortKey="Floriano, Pierre N" sort="Floriano, Pierre N" uniqKey="Floriano P" first="Pierre N" last="Floriano">Pierre N. Floriano</name><affiliation><nlm:aff id="A4">Bioengineering & Chemistry, Rice University, Houston, TX, USA</nlm:aff></affiliation></author><author><name sortKey="Simmons, Glennon" sort="Simmons, Glennon" uniqKey="Simmons G" first="Glennon" last="Simmons">Glennon Simmons</name><affiliation><nlm:aff id="A4">Bioengineering & Chemistry, Rice University, Houston, TX, USA</nlm:aff></affiliation></author><author><name sortKey="Bhagwandin, Bryon" sort="Bhagwandin, Bryon" uniqKey="Bhagwandin B" first="Bryon" last="Bhagwandin">Bryon Bhagwandin</name><affiliation><nlm:aff id="A5">LabNow Inc., Austin, TX, USA</nlm:aff></affiliation></author><author><name sortKey="Jacobson, James W" sort="Jacobson, James W" uniqKey="Jacobson J" first="James W" last="Jacobson">James W. Jacobson</name><affiliation><nlm:aff id="A5">LabNow Inc., Austin, TX, USA</nlm:aff></affiliation></author><author><name sortKey="Redding, Spencer W" sort="Redding, Spencer W" uniqKey="Redding S" first="Spencer W" last="Redding">Spencer W. Redding</name><affiliation><nlm:aff id="A6">Department of Dental Diagnostic Sciences, University of Texas, San Antonio, TX, USA</nlm:aff></affiliation></author><author><name sortKey="Ebersole, Jeffrey L" sort="Ebersole, Jeffrey L" uniqKey="Ebersole J" first="Jeffrey L" last="Ebersole">Jeffrey L. Ebersole</name><affiliation><nlm:aff id="A1">Oral Medicine Section, MN 324, University of Kentucky College of Dentistry, 800 Rose Street, Lexington, KY 40536-0297, USA Tel.: +1 859 323 5598<email>cmiller@uky.edu</email></nlm:aff></affiliation></author><author><name sortKey="Mcdevitt, John T" sort="Mcdevitt, John T" uniqKey="Mcdevitt J" first="John T" last="Mcdevitt">John T. Mcdevitt</name><affiliation><nlm:aff id="A4">Bioengineering & Chemistry, Rice University, Houston, TX, USA</nlm:aff></affiliation></author></analytic><series><title level="j">Biomarkers in medicine</title><idno type="ISSN">1752-0363</idno><idno type="eISSN">1752-0371</idno><imprint><date when="2010">2010</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P1">Salivary diagnostics is an emerging field that has progressed through several important developments in the past decade, including the publication of the human salivary proteome and the infusion of federal funds to integrate nanotechnologies and microfluidic engineering concepts into developing compact point-of-care devices for rapid analysis of this secretion. In this article, we discuss some of these developments and their relevance to the prognosis, diagnosis and management of periodontitis, as an oral target, and cardiovascular disease, as a systemic example for the potential of these biodiagnostics. Our findings suggest that several biomarkers are associated with distinct biological stages of these diseases and demonstrate promise as practical biomarkers in identifying and managing periodontal disease, and acute myocardial infarction. The majority of these studies have progressed through biomarker discovery, with the identified molecules requiring more robust clinical studies to enable substantive validation for disease diagnosis. It is predicted that with continued advances in this field the use of a combination of biomarkers in multiplex panels is likely to yield accurate screening tools for these diagnoses in the near future.</p></div></front></TEI><pmc article-type="research-article" xml:lang="EN"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">101312535</journal-id><journal-id journal-id-type="pubmed-jr-id">34881</journal-id><journal-id journal-id-type="nlm-ta">Biomark Med</journal-id><journal-title>Biomarkers in medicine</journal-title><issn pub-type="ppub">1752-0363</issn><issn pub-type="epub">1752-0371</issn></journal-meta><article-meta><article-id pub-id-type="pmid">20387312</article-id><article-id pub-id-type="pmc">2857781</article-id><article-id pub-id-type="manuscript">NIHMS180637</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Current developments in salivary diagnostics</article-title></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name><surname>Miller</surname><given-names>Craig S</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Foley</surname><given-names>Joseph D</given-names></name><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Bailey</surname><given-names>Alison L</given-names></name><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Campell</surname><given-names>Charles L</given-names></name><xref ref-type="aff" rid="A2">2</xref><xref ref-type="aff" rid="A3">3</xref></contrib><contrib contrib-type="author"><name><surname>Humphries</surname><given-names>Roger L</given-names></name><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Christodoulides</surname><given-names>Nicolaos</given-names></name><xref ref-type="aff" rid="A4">4</xref></contrib><contrib contrib-type="author"><name><surname>Floriano</surname><given-names>Pierre N</given-names></name><xref ref-type="aff" rid="A4">4</xref></contrib><contrib contrib-type="author"><name><surname>Simmons</surname><given-names>Glennon</given-names></name><xref ref-type="aff" rid="A4">4</xref></contrib><contrib contrib-type="author"><name><surname>Bhagwandin</surname><given-names>Bryon</given-names></name><xref ref-type="aff" rid="A5">5</xref></contrib><contrib contrib-type="author"><name><surname>Jacobson</surname><given-names>James W</given-names></name><xref ref-type="aff" rid="A5">5</xref></contrib><contrib contrib-type="author"><name><surname>Redding</surname><given-names>Spencer W</given-names></name><xref ref-type="aff" rid="A6">6</xref></contrib><contrib contrib-type="author"><name><surname>Ebersole</surname><given-names>Jeffrey L</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>McDevitt</surname><given-names>John T</given-names></name><xref ref-type="aff" rid="A4">4</xref></contrib></contrib-group><aff id="A1"><label>1</label>Oral Medicine Section, MN 324, University of Kentucky College of Dentistry, 800 Rose Street, Lexington, KY 40536-0297, USA Tel.: +1 859 323 5598<email>cmiller@uky.edu</email></aff><aff id="A2"><label>2</label>Gill Heart Institute, University of Kentucky, Lexington, KY, USA</aff><aff id="A3"><label>3</label>Lexington Veterans Administration Hospital, Lexington, KY, USA</aff><aff id="A4"><label>4</label>Bioengineering & Chemistry, Rice University, Houston, TX, USA</aff><aff id="A5"><label>5</label>LabNow Inc., Austin, TX, USA</aff><aff id="A6"><label>6</label>Department of Dental Diagnostic Sciences, University of Texas, San Antonio, TX, USA</aff><pub-date pub-type="nihms-submitted"><day>16</day><month>3</month><year>2010</year></pub-date><pub-date pub-type="ppub"><month>2</month><year>2010</year></pub-date><pub-date pub-type="pmc-release"><day>1</day><month>12</month><year>2010</year></pub-date><volume>4</volume><issue>1</issue><fpage>171</fpage><lpage>189</lpage><permissions><copyright-statement>© 2010 Future Medicine Ltd</copyright-statement><copyright-year>2010</copyright-year></permissions><abstract><p id="P1">Salivary diagnostics is an emerging field that has progressed through several important developments in the past decade, including the publication of the human salivary proteome and the infusion of federal funds to integrate nanotechnologies and microfluidic engineering concepts into developing compact point-of-care devices for rapid analysis of this secretion. In this article, we discuss some of these developments and their relevance to the prognosis, diagnosis and management of periodontitis, as an oral target, and cardiovascular disease, as a systemic example for the potential of these biodiagnostics. Our findings suggest that several biomarkers are associated with distinct biological stages of these diseases and demonstrate promise as practical biomarkers in identifying and managing periodontal disease, and acute myocardial infarction. The majority of these studies have progressed through biomarker discovery, with the identified molecules requiring more robust clinical studies to enable substantive validation for disease diagnosis. It is predicted that with continued advances in this field the use of a combination of biomarkers in multiplex panels is likely to yield accurate screening tools for these diagnoses in the near future.</p></abstract><kwd-group><kwd>acute myocardial infarction</kwd><kwd>lab-on-a-chip</kwd><kwd>periodontitis</kwd><kwd>salivary diagnosis</kwd></kwd-group><contract-num rid="DE1">U01 DE017793-04
||DE</contract-num><contract-num rid="DE1">U01 DE017793-03
||DE</contract-num><contract-num rid="DE1">U01 DE017793-02
||DE</contract-num><contract-num rid="DE1">U01 DE017793-01
||DE</contract-num><contract-sponsor id="DE1">National Institute of Dental and Craniofacial Research : NIDCR</contract-sponsor></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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