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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Factors associated with osteonecrosis of the jaw among bisphosponate users</title><author><name sortKey="Hess, Lisa M" sort="Hess, Lisa M" uniqKey="Hess L" first="Lisa M" last="Hess">Lisa M. Hess</name><affiliation><nlm:aff id="A1">College of Medicine, Arizona Cancer Center, University of Arizona Tucson AZ 85724</nlm:aff></affiliation></author><author><name sortKey="Jeter, Joanne M" sort="Jeter, Joanne M" uniqKey="Jeter J" first="Joanne M" last="Jeter">Joanne M. Jeter</name><affiliation><nlm:aff id="A1">College of Medicine, Arizona Cancer Center, University of Arizona Tucson AZ 85724</nlm:aff></affiliation></author><author><name sortKey="Benham Hutchins, Marge" sort="Benham Hutchins, Marge" uniqKey="Benham Hutchins M" first="Marge" last="Benham-Hutchins">Marge Benham-Hutchins</name><affiliation><nlm:aff id="A1">College of Medicine, Arizona Cancer Center, University of Arizona Tucson AZ 85724</nlm:aff></affiliation><affiliation><nlm:aff id="A2">College of Nursing, University of Arizona Tucson AZ 85721</nlm:aff></affiliation></author><author><name sortKey="Alberts, David S" sort="Alberts, David S" uniqKey="Alberts D" first="David S." last="Alberts">David S. Alberts</name><affiliation><nlm:aff id="A1">College of Medicine, Arizona Cancer Center, University of Arizona Tucson AZ 85724</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">18501224</idno><idno type="pmc">2601671</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2601671</idno><idno type="RBID">PMC:2601671</idno><idno type="doi">10.1016/j.amjmed.2008.01.047</idno><date when="2008">2008</date><idno type="wicri:Area/Pmc/Corpus">002079</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002079</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Factors associated with osteonecrosis of the jaw among bisphosponate users</title><author><name sortKey="Hess, Lisa M" sort="Hess, Lisa M" uniqKey="Hess L" first="Lisa M" last="Hess">Lisa M. Hess</name><affiliation><nlm:aff id="A1">College of Medicine, Arizona Cancer Center, University of Arizona Tucson AZ 85724</nlm:aff></affiliation></author><author><name sortKey="Jeter, Joanne M" sort="Jeter, Joanne M" uniqKey="Jeter J" first="Joanne M" last="Jeter">Joanne M. Jeter</name><affiliation><nlm:aff id="A1">College of Medicine, Arizona Cancer Center, University of Arizona Tucson AZ 85724</nlm:aff></affiliation></author><author><name sortKey="Benham Hutchins, Marge" sort="Benham Hutchins, Marge" uniqKey="Benham Hutchins M" first="Marge" last="Benham-Hutchins">Marge Benham-Hutchins</name><affiliation><nlm:aff id="A1">College of Medicine, Arizona Cancer Center, University of Arizona Tucson AZ 85724</nlm:aff></affiliation><affiliation><nlm:aff id="A2">College of Nursing, University of Arizona Tucson AZ 85721</nlm:aff></affiliation></author><author><name sortKey="Alberts, David S" sort="Alberts, David S" uniqKey="Alberts D" first="David S." last="Alberts">David S. Alberts</name><affiliation><nlm:aff id="A1">College of Medicine, Arizona Cancer Center, University of Arizona Tucson AZ 85724</nlm:aff></affiliation></author></analytic><series><title level="j">The American journal of medicine</title><idno type="ISSN">0002-9343</idno><idno type="eISSN">1555-7162</idno><imprint><date when="2008">2008</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="S1"><title>Background</title><p id="P1">Bisphosphonates are medications that impact bone reformation by inhibiting osteoclast function. Osteonecrosis of the jaw has been reported among patients receiving these medications. It is unclear if the risk factors associated with osteonecrosis of the jaw among cancer patients taking bisphosphonates are also possible risk factors among patients receiving these medications for other indications.</p></sec><sec sec-type="methods" id="S2"><title>Methods</title><p id="P2">A systematic review search strategy was used to identify cases of osteonecrosis of the jaw among patients taking bisphosphonates for an indication other than cancer to identify potential contributing factors. Data were analyzed according to previous models to develop a more expanded model that may explain possible mechanisms for the development of osteonecrosis of the jaw among patients without cancer.</p></sec><sec id="S3"><title>Results</title><p id="P3">Ninety-nine cases of osteonecrosis of the jaw were identified among patients who were prescribed a bisphosphonate for an indication other than cancer. These cases included 85 osteoporosis patients, 10 patients with Paget’s disease, two patients with rheumatoid arthritis, one patient with diabetes and one patient with maxillary fibrous dysplasia. The mean age was 69.4 years, 87.3% were female, and 87.6% were receiving oral, but not intravenous, bisphosphonates. Of the 63 patients reporting dental care information, 88.9% had a dental procedure prior to the onset of osteonecrosis of the jaw. Of all cases providing medical information, 71% were taking at least one medication that affects bone turnover in addition to the bisphosphonate, and 81.6% reported additional underlying health conditions.</p></sec><sec id="S4"><title>Conclusions</title><p id="P4">The case details suggest a multiplicity of factors associated with this condition and provide the foundation for a model outlining the potential mechanism for the development of osteonecrosis of the jaw among patients taking bisphosphonates for an indication other than cancer.</p></sec></div></front></TEI><pmc article-type="research-article" xml:lang="EN"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">0267200</journal-id><journal-id journal-id-type="pubmed-jr-id">431</journal-id><journal-id journal-id-type="nlm-ta">Am J Med</journal-id><journal-title>The American journal of medicine</journal-title><issn pub-type="ppub">0002-9343</issn><issn pub-type="epub">1555-7162</issn></journal-meta><article-meta><article-id pub-id-type="pmid">18501224</article-id><article-id pub-id-type="pmc">2601671</article-id><article-id pub-id-type="manuscript">NIHMS52888</article-id><article-id pub-id-type="doi">10.1016/j.amjmed.2008.01.047</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Factors associated with osteonecrosis of the jaw among bisphosponate users</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Hess</surname><given-names>Lisa M</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Jeter</surname><given-names>Joanne M</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Benham-Hutchins</surname><given-names>Marge</given-names></name><xref ref-type="aff" rid="A1">1</xref><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Alberts</surname><given-names>David S.</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib></contrib-group><aff id="A1"><label>1</label>College of Medicine, Arizona Cancer Center, University of Arizona Tucson AZ 85724</aff><aff id="A2"><label>2</label>College of Nursing, University of Arizona Tucson AZ 85721</aff><author-notes><corresp id="cor1"><italic>Address for Correspondence:</italic> Lisa M Hess, PhD, Arizona Cancer Center, Cancer Prevention and Control, 1515 N Campbell Avenue, Tucson AZ 85724-5024, Phone: (520) 626-1387; Fax: (520) 626-5350; email: <email>hess@u.arizona.edu</email></corresp></author-notes><pub-date pub-type="nihms-submitted"><day>24</day><month>6</month><year>2008</year></pub-date><pub-date pub-type="ppub"><month>6</month><year>2008</year></pub-date><pub-date pub-type="pmc-release"><day>1</day><month>6</month><year>2009</year></pub-date><volume>121</volume><issue>6</issue><fpage>475</fpage><lpage>483.e3</lpage><abstract><sec id="S1"><title>Background</title><p id="P1">Bisphosphonates are medications that impact bone reformation by inhibiting osteoclast function. Osteonecrosis of the jaw has been reported among patients receiving these medications. It is unclear if the risk factors associated with osteonecrosis of the jaw among cancer patients taking bisphosphonates are also possible risk factors among patients receiving these medications for other indications.</p></sec><sec sec-type="methods" id="S2"><title>Methods</title><p id="P2">A systematic review search strategy was used to identify cases of osteonecrosis of the jaw among patients taking bisphosphonates for an indication other than cancer to identify potential contributing factors. Data were analyzed according to previous models to develop a more expanded model that may explain possible mechanisms for the development of osteonecrosis of the jaw among patients without cancer.</p></sec><sec id="S3"><title>Results</title><p id="P3">Ninety-nine cases of osteonecrosis of the jaw were identified among patients who were prescribed a bisphosphonate for an indication other than cancer. These cases included 85 osteoporosis patients, 10 patients with Paget’s disease, two patients with rheumatoid arthritis, one patient with diabetes and one patient with maxillary fibrous dysplasia. The mean age was 69.4 years, 87.3% were female, and 87.6% were receiving oral, but not intravenous, bisphosphonates. Of the 63 patients reporting dental care information, 88.9% had a dental procedure prior to the onset of osteonecrosis of the jaw. Of all cases providing medical information, 71% were taking at least one medication that affects bone turnover in addition to the bisphosphonate, and 81.6% reported additional underlying health conditions.</p></sec><sec id="S4"><title>Conclusions</title><p id="P4">The case details suggest a multiplicity of factors associated with this condition and provide the foundation for a model outlining the potential mechanism for the development of osteonecrosis of the jaw among patients taking bisphosphonates for an indication other than cancer.</p></sec></abstract><kwd-group><kwd>bisphosphonates</kwd><kwd>osteonecrosis of the jaw</kwd><kwd>osteoporosis</kwd><kwd>Paget’s diesase</kwd></kwd-group><contract-num rid="CA1">R25 CA078447-09</contract-num><contract-num rid="CA1">P30 CA023074-30</contract-num><contract-sponsor id="CA1">National Cancer Institute : NCI</contract-sponsor></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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