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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Computer Tomograph (CT) imaging of mandibular anatomical substrate in animal model restored with nanostructured hydroxyapatite compounds</title><author><name sortKey="Ciuluvic, R" sort="Ciuluvic, R" uniqKey="Ciuluvic R" first="R" last="Ciuluvic">R. Ciuluvic</name><affiliation><nlm:aff id="A1">Anatomy Department, “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania</nlm:aff></affiliation></author><author><name sortKey="Gr Dinaru, S" sort="Gr Dinaru, S" uniqKey="Gr Dinaru S" first="S" last="Gr Dinaru">S. Gr Dinaru</name><affiliation><nlm:aff id="A2">Ophthalmology Department, “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania</nlm:aff></affiliation></author><author><name sortKey="Popescu, M" sort="Popescu, M" uniqKey="Popescu M" first="M" last="Popescu">M. Popescu</name><affiliation><nlm:aff id="A3">Institute for Nonferous and Rare Materials, Bucharest, Romania</nlm:aff></affiliation></author><author><name sortKey="Piticescu, Rm" sort="Piticescu, Rm" uniqKey="Piticescu R" first="Rm" last="Piticescu">Rm Piticescu</name><affiliation><nlm:aff id="A3">Institute for Nonferous and Rare Materials, Bucharest, Romania</nlm:aff></affiliation></author><author><name sortKey="Cergan, R" sort="Cergan, R" uniqKey="Cergan R" first="R" last="Cergan">R. Cergan</name><affiliation><nlm:aff id="A3">Institute for Nonferous and Rare Materials, Bucharest, Romania</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">25914749</idno><idno type="pmc">4397532</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4397532</idno><idno type="RBID">PMC:4397532</idno><date when="2015">2015</date><idno type="wicri:Area/Pmc/Corpus">001E70</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001E70</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Computer Tomograph (CT) imaging of mandibular anatomical substrate in animal model restored with nanostructured hydroxyapatite compounds</title><author><name sortKey="Ciuluvic, R" sort="Ciuluvic, R" uniqKey="Ciuluvic R" first="R" last="Ciuluvic">R. Ciuluvic</name><affiliation><nlm:aff id="A1">Anatomy Department, “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania</nlm:aff></affiliation></author><author><name sortKey="Gr Dinaru, S" sort="Gr Dinaru, S" uniqKey="Gr Dinaru S" first="S" last="Gr Dinaru">S. Gr Dinaru</name><affiliation><nlm:aff id="A2">Ophthalmology Department, “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania</nlm:aff></affiliation></author><author><name sortKey="Popescu, M" sort="Popescu, M" uniqKey="Popescu M" first="M" last="Popescu">M. Popescu</name><affiliation><nlm:aff id="A3">Institute for Nonferous and Rare Materials, Bucharest, Romania</nlm:aff></affiliation></author><author><name sortKey="Piticescu, Rm" sort="Piticescu, Rm" uniqKey="Piticescu R" first="Rm" last="Piticescu">Rm Piticescu</name><affiliation><nlm:aff id="A3">Institute for Nonferous and Rare Materials, Bucharest, Romania</nlm:aff></affiliation></author><author><name sortKey="Cergan, R" sort="Cergan, R" uniqKey="Cergan R" first="R" last="Cergan">R. Cergan</name><affiliation><nlm:aff id="A3">Institute for Nonferous and Rare Materials, Bucharest, Romania</nlm:aff></affiliation></author></analytic><series><title level="j">Journal of Medicine and Life</title><idno type="ISSN">1844-122X</idno><idno type="eISSN">1844-3117</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><bold>Introduction:</bold> This study was meant to test a new type of bone graft on an animal model. This material was a nanostructured hydroxyapatite.</p><p><bold>Materials and Methods:</bold> the study was conducted according to Ethic Committee Regulation on animal model (Oryctolagus cuniculus – rabbit) between August and November 2014, at “Carol Davila” University of Medicine and Pharmacy, Bucharest. The animals were tested by using a CT at the level of the mandible before and after using the nanostructured hydroxyapatite.</p><p><bold>Results:</bold> The animals were CT scanned at 1, 2 and respectively 3 months, noticing a growth of the mandibular bone density. After 3 months, a bone density equal with the density of the healthy bone was noticed.</p><p><bold>Conclusions:</bold> The use of the bone graft could be a viable alternative to available materials. The advantage was that bone recovery had a density similar to the density of the healthy bone and the cost of production was low because it was made out of Calcium azotate and monobasic ammonium phosphate.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Dumitrescu, Al" uniqKey="Dumitrescu A">AL Dumitrescu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lindhe, J" uniqKey="Lindhe J">J Lindhe</name></author><author><name sortKey="Lang, Np" uniqKey="Lang N">NP Lang</name></author><author><name sortKey="Karring, T" uniqKey="Karring T">T Karring</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Misch, Ce" uniqKey="Misch C">CE Misch</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zitzmann, Nu" uniqKey="Zitzmann N">NU Zitzmann</name></author><author><name sortKey="Marinello, Cp" uniqKey="Marinello C">CP Marinello</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kumar, P" uniqKey="Kumar P">P Kumar</name></author><author><name sortKey="Belliappa, V" uniqKey="Belliappa V">V Belliappa</name></author><author><name sortKey="Ghousia, F" uniqKey="Ghousia F">F Ghousia</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Conrad, Eu" uniqKey="Conrad E">EU Conrad</name></author><author><name sortKey="Gretch, Dr" uniqKey="Gretch D">DR Gretch</name></author><author><name sortKey="Obermeyer, Kr" uniqKey="Obermeyer K">KR Obermeyer</name></author><author><name sortKey="Moogk, Ms" uniqKey="Moogk M">MS Moogk</name></author><author><name sortKey="Sayers, M" uniqKey="Sayers M">M Sayers</name></author><author><name sortKey="Wilson, Jj" uniqKey="Wilson J">JJ Wilson</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Valdes, Ma" uniqKey="Valdes M">MA Valdes</name></author><author><name sortKey="Thakur, Na" uniqKey="Thakur N">NA Thakur</name></author><author><name sortKey="Namdari, S" uniqKey="Namdari S">S Namdari</name></author><author><name sortKey="Ciombor, Dm" uniqKey="Ciombor D">DM Ciombor</name></author><author><name sortKey="Palumbo, M" uniqKey="Palumbo M">M Palumbo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mulconrey, Ds" uniqKey="Mulconrey D">DS Mulconrey</name></author><author><name sortKey="Birdwell, Kh" uniqKey="Birdwell K">KH Birdwell</name></author><author><name sortKey="Flynn, J" uniqKey="Flynn J">J Flynn</name></author><author><name sortKey="Cronen, Ga" uniqKey="Cronen G">GA Cronen</name></author><author><name sortKey="Rose, Ps" uniqKey="Rose P">PS Rose</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Waked, W" uniqKey="Waked W">W Waked</name></author><author><name sortKey="Grauer, J" uniqKey="Grauer J">J Grauer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Giannoudis, Pv" uniqKey="Giannoudis P">PV Giannoudis</name></author><author><name sortKey="Dinopoulos, H" uniqKey="Dinopoulos H">H Dinopoulos</name></author><author><name sortKey="Tsiridis, E" uniqKey="Tsiridis E">E Tsiridis</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ogle, Oe" uniqKey="Ogle O">OE Ogle</name></author><author><name sortKey="Byles, N" uniqKey="Byles N">N Byles</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Popescu, M" uniqKey="Popescu M">M Popescu</name></author><author><name sortKey="Meghea, A" uniqKey="Meghea A">A Meghea</name></author><author><name sortKey="Piticescu, Rm" uniqKey="Piticescu R">RM Piticescu</name></author><author><name sortKey="Vasile, E" uniqKey="Vasile E">E Vasile</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Piticescu, Rm" uniqKey="Piticescu R">RM Piticescu</name></author><author><name sortKey="Popescu, Lm" uniqKey="Popescu L">LM Popescu</name></author><author><name sortKey="Meghea, A" uniqKey="Meghea A">A Meghea</name></author><author><name sortKey="Badilita, V" uniqKey="Badilita V">V Badilita</name></author><author><name sortKey="Vasile, E" uniqKey="Vasile E">E Vasile</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Harriott, Vj" uniqKey="Harriott V">VJ Harriott</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Popescu, Lm" uniqKey="Popescu L">LM Popescu</name></author><author><name sortKey="Rusti, Cf" uniqKey="Rusti C">CF Rusti</name></author><author><name sortKey="Piticescu, Rm" uniqKey="Piticescu R">RM Piticescu</name></author><author><name sortKey="Valero, T" uniqKey="Valero T">T Valero</name></author><author><name sortKey="Kintzios, S" uniqKey="Kintzios S">S Kintzios</name></author><author><name sortKey="Buruiana, T" uniqKey="Buruiana T">T Buruiana</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Popescu, Lm" uniqKey="Popescu L">LM Popescu</name></author><author><name sortKey="Piticescu, Rm" uniqKey="Piticescu R">RM Piticescu</name></author><author><name sortKey="Buruiana, T" uniqKey="Buruiana T">T Buruiana</name></author><author><name sortKey="Vasile, E" uniqKey="Vasile E">E Vasile</name></author><author><name sortKey="Trusca, R" uniqKey="Trusca R">R Trusca</name></author><author><name sortKey="Badilita, V" uniqKey="Badilita V">V Badilita</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Piticescu, Rm" uniqKey="Piticescu R">RM Piticescu</name></author><author><name sortKey="Popescu, Lm" uniqKey="Popescu L">LM Popescu</name></author><author><name sortKey="Buruiana, T" uniqKey="Buruiana T">T Buruiana</name></author></analytic></biblStruct></listBibl></div1></back></TEI><pmc article-type="case-report"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">J Med Life</journal-id><journal-id journal-id-type="iso-abbrev">J Med Life</journal-id><journal-id journal-id-type="publisher-id">JMedLife</journal-id><journal-title-group><journal-title>Journal of Medicine and Life</journal-title></journal-title-group><issn pub-type="ppub">1844-122X</issn><issn pub-type="epub">1844-3117</issn><publisher><publisher-name>Carol Davila University Press</publisher-name><publisher-loc>Romania</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">25914749</article-id><article-id pub-id-type="pmc">4397532</article-id><article-id pub-id-type="publisher-id">JMedLife-08-99</article-id><article-categories><subj-group subj-group-type="heading"><subject>Case Presentations</subject></subj-group></article-categories><title-group><article-title>Computer Tomograph (CT) imaging of mandibular anatomical substrate in animal model restored with nanostructured hydroxyapatite compounds</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Ciuluvică</surname><given-names>R</given-names></name><xref ref-type="aff" rid="A1">*</xref></contrib><contrib contrib-type="author"><name><surname>Grădinaru</surname><given-names>S</given-names></name><xref ref-type="aff" rid="A2">**</xref></contrib><contrib contrib-type="author"><name><surname>Popescu</surname><given-names>M</given-names></name><xref ref-type="aff" rid="A3">***</xref></contrib><contrib contrib-type="author"><name><surname>Piticescu</surname><given-names>RM</given-names></name><xref ref-type="aff" rid="A3">***</xref></contrib><contrib contrib-type="author"><name><surname>Cergan</surname><given-names>R</given-names></name><xref ref-type="aff" rid="A3">***</xref></contrib></contrib-group><aff id="A1"><label>*</label>Anatomy Department, “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania</aff><aff id="A2"><label>**</label>Ophthalmology Department, “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania</aff><aff id="A3"><label>***</label>Institute for Nonferous and Rare Materials, Bucharest, Romania</aff><author-notes><corresp><bold>Correspondence to:</bold>Gradinaru S, MD
Ophthalmology Department, “Carol Davila” University of Medicine and Pharmacy
8 Eroilor Sanitari Blvd., Bucharest, Romania,
Mobile phone: +40 726 535 515, E-mail: sanzinic@yahoo.com
</corresp></author-notes><pub-date pub-type="ppub"><season>Jan-Mar</season><year>2015</year></pub-date><volume>8</volume><issue>1</issue><fpage>99</fpage><lpage>102</lpage><history><date date-type="received"><day>24</day><month>8</month><year>2014</year></date><date date-type="accepted"><day>17</day><month>12</month><year>2014</year></date></history><permissions><copyright-statement>©Carol Davila University Press
</copyright-statement><copyright-year>2014</copyright-year><license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by/2.0/"><license-p>This is
an open-access article distributed under the terms of the Creative
Commons Attribution License, which permits unrestricted use,
distribution, and reproduction in any medium, provided the original work
is properly cited.</license-p></license></permissions><abstract><p><bold>Introduction:</bold> This study was meant to test a new type of bone graft on an animal model. This material was a nanostructured hydroxyapatite.</p><p><bold>Materials and Methods:</bold> the study was conducted according to Ethic Committee Regulation on animal model (Oryctolagus cuniculus – rabbit) between August and November 2014, at “Carol Davila” University of Medicine and Pharmacy, Bucharest. The animals were tested by using a CT at the level of the mandible before and after using the nanostructured hydroxyapatite.</p><p><bold>Results:</bold> The animals were CT scanned at 1, 2 and respectively 3 months, noticing a growth of the mandibular bone density. After 3 months, a bone density equal with the density of the healthy bone was noticed.</p><p><bold>Conclusions:</bold> The use of the bone graft could be a viable alternative to available materials. The advantage was that bone recovery had a density similar to the density of the healthy bone and the cost of production was low because it was made out of Calcium azotate and monobasic ammonium phosphate.</p></abstract><kwd-group><kwd>hydroxyapatite</kwd><kwd>dental implant</kwd><kwd>bone reconstruction</kwd><kwd>nanostructured polymers</kwd></kwd-group></article-meta></front><body><sec sec-type="intro" id="sec1-1"><title>Introduction</title><p>Bone graft materials are used in various orthopedic and maxillofacial surgery procedures for the treatment of bony defects caused by fractures, tumor resections or bone loss. In the last decades, different types of graft biomaterials with various origins have been developed, displaying specific advantages and disadvantages. In general, bone substitution materials can be categorized into natural bone grafts (autografts, allografts, xenografts, coralline) and synthetic bone grafts (alloplasts).</p><p>Hydroxyapatite is one of the materials frequently used in the reconstruction of dental bone defects.</p><p>This type of material is part of the category of biomaterials, which are classified as it follows [<bold><xref rid="R1" ref-type="bibr">1</xref></bold>-<bold><xref rid="R5" ref-type="bibr">5</xref></bold>]:</p><p>A) Autografs - autologous or autogenous bone grafting involves the use of the bone obtained from the same individual receiving the graft.</p><p>B) Allografts - Allograft is derived from humans. The difference is that the allograft is harvested from an individual other than the one receiving the graft [<bold><xref rid="R6" ref-type="bibr">6</xref></bold>-<bold><xref rid="R8" ref-type="bibr">8</xref></bold>].</p><p>C) Synthetic variants - Flexible hydrogel-hydroxyapatite (HA) composite which has a mineral.</p><p>D) Xenograft - Xenogratfs are bone grafts from a species other than human, such as bovine, and are used as a calcified matrix [<bold><xref rid="R9" ref-type="bibr">9</xref></bold>].</p><p>E) Alloplastic grafts - Alloplastic grafts may be made from hydroxyapatite, a naturally occurring mineral (main mineral component of bone) [<bold><xref rid="R10" ref-type="bibr">10</xref></bold>].</p><p>F) Ceramic-based bone graft substitutes (calcium sulfate, bioactive glass, and calcium phosphate) [<bold><xref rid="R11" ref-type="bibr">11</xref></bold>].</p><p>G) Polymer-based bone graft substitutes [<bold><xref rid="R12" ref-type="bibr">12</xref></bold>].</p><p>The materials must meet the following properties: osteoconduction, osteoinduction, and osteogenesis [<bold><xref rid="R8" ref-type="bibr">8</xref></bold>].</p><p>Depending on their use, bone grafts are available in different forms: hydroxyapatite granules of animal origin, spongious blocks of natural bone, elastic lamella of the cortical bone and formable, collagen paste from animal bone, etc. [<bold><xref rid="R13" ref-type="bibr">13</xref></bold>].</p><p>Calcium phosphates are the most abundant inorganic constituents of the living beings hard tissue, which provide bone and teeth with hardness, density and mechanical stability. Hydroxyapatite (Ca10(PO4)6(OH)2) is the main calcium phosphate in these tissues and the crystal unit cell comprises two entities.</p><p>The biomaterial used in our study is obtained from Calcium azotate and ammonium phosphate monobasic with a low risk of infectious disease, increased biocompatibility and low reactivity, polymers that were used for various medical applications, especially for dental surgery procedures [<bold><xref rid="R14" ref-type="bibr">14</xref></bold>-<bold><xref rid="R16" ref-type="bibr">16</xref></bold>].</p><p>Hydroxyapatite based nanostructured hybrids was synthesized by hydrothermal procedure at high pressure (>300 atm) and low temperatures (<200 °C), starting from Calcium azotate and ammonium phosphate monobasic and natural polymers such as type I collagen or alginate [<bold><xref rid="R17" ref-type="bibr">17</xref></bold>-<bold><xref rid="R19" ref-type="bibr">19</xref></bold>].</p></sec><sec sec-type="materials|methods" id="sec1-2"><title>Materials and methods</title><p>The purpose of this study was to reconstruct the mandibular osseous substrate with nanostructured hydroxyapatite from Calcium azotate and ammonium phosphate monobasic.</p><p>This study was rolled out from August to November 2014, on 20 male animal models - Oryctolagus cuniculus (rabbit), age 24 weeks following our Ethical Committee regulation regarding animal testing.</p><p>Sterile nanostructured hydroxyapatite powder from Calcium azotate and ammonium phosphate monobasic as provided by Institute of Nonferrous and Rare Materials Bucharest after the chemical characterization and SEM characterization (<bold><xref ref-type="fig" rid="F1">Fig. 1</xref></bold>).</p><fig id="F1" position="float"><label>Fig. 1</label><caption><p>SEM characterization of hydroxyapatite nanopowder</p></caption><graphic xlink:href="JMedLife-08-99-g001"></graphic></fig><p>In August, CT scans of rabbit mandible were performed and after the CT scan, the surgical step of this study, consisting in left incisive extraction and bone reconstruction by using nanostructured hydroxyapatite, was performed. CT scans assessed the bone density with SOMATOM – Siemens-software version syngoDENTAL CT2007E and 3D reconstruction made by 3D Recon software, HeadSpi/ Fine Sections program, which is used for routine investigations of the head, investigations of the base of the skull and brain, skull tumors, etc.</p><fig id="F2" position="float"><label>Fig. 2</label><caption><p>CT investigations at 1 month and 3 months after surgery showing central and peripheral bone density of mandible</p></caption><graphic xlink:href="JMedLife-08-99-g002"></graphic></fig></sec><sec sec-type="Results" id="sec1-3"><title>Results</title><p>Several CT image investigations were performed after the surgery by using the HeadSpi/ Fine sections 0.6-2.4 program.</p><p>The images were taken as it follows:</p><p>1) Topogram for choosing the segment of interest.</p><p>2) Initial aquisition of 2.4 in order to shorten the exposure and aquisition time for movements artifacts.</p><p>3) Reconstruction, HeadSecv 1.2, Headsecv. 0.6, and SSD (3D), frontal and sagital MPR range.</p><p>The following technical parameters were used (<bold><xref ref-type="table" rid="T1">Table 1</xref></bold>):</p><table-wrap id="T1" position="float"><label>Table 1</label><caption><p>Parameters used for CT scans (SOMATOM – Siemens-software version syngoDENTAL CT2007E)</p></caption><table frame="hsides" rules="groups"><tbody><tr><td align="center" rowspan="1" colspan="1">kV</td><td align="center" rowspan="1" colspan="1">130</td></tr><tr><td align="center" rowspan="1" colspan="1">mAs</td><td align="center" rowspan="1" colspan="1">270</td></tr><tr><td align="center" rowspan="1" colspan="1">Slice col.</td><td align="center" rowspan="1" colspan="1">4x1 mm</td></tr><tr><td align="center" rowspan="1" colspan="1">Tomogram</td><td align="center" rowspan="1" colspan="1">256 mm</td></tr><tr><td align="center" rowspan="1" colspan="1">Slice width </td><td align="center" rowspan="1" colspan="1">2-4 mm</td></tr><tr><td align="center" rowspan="1" colspan="1">Feed/Rot</td><td align="center" rowspan="1" colspan="1">2.6 mm</td></tr><tr><td align="center" rowspan="1" colspan="1">Rot.time</td><td align="center" rowspan="1" colspan="1">0.75 s</td></tr><tr><td align="center" rowspan="1" colspan="1">Kernel</td><td align="center" rowspan="1" colspan="1">H 20s</td></tr><tr><td align="center" rowspan="1" colspan="1">Increm.</td><td align="center" rowspan="1" colspan="1">4-0,7mm</td></tr><tr><td align="center" rowspan="1" colspan="1">Direction</td><td align="center" rowspan="1" colspan="1">ca-cr</td></tr><tr><td align="center" rowspan="1" colspan="1">Scan range</td><td align="center" rowspan="1" colspan="1">40mm</td></tr><tr><td align="center" rowspan="1" colspan="1">CTDIw</td><td align="center" rowspan="1" colspan="1">71.5 m Gy</td></tr></tbody></table></table-wrap><p>All the images were digitally reconstructed (<bold><xref ref-type="table" rid="T2">Table 2</xref></bold>), by using tri and bi-dimensional, frontal and sagittal reconstructions (MPR Range/ MPR Range 1).</p><table-wrap id="T2" position="float"><label>Table 2</label><caption><p>The technical parameters for reconstructions</p></caption><table frame="hsides" rules="groups"><tbody><tr><td align="center" rowspan="1" colspan="1">Rec.</td><td align="center" rowspan="1" colspan="1">1.2-0.6mm</td></tr><tr><td align="center" rowspan="1" colspan="1">Kernel/bone</td><td align="center" rowspan="1" colspan="1">H 90 s ultra sharp</td></tr><tr><td align="center" rowspan="1" colspan="1">Kernel/orbit</td><td align="center" rowspan="1" colspan="1">H 60 s medium sharp</td></tr></tbody></table></table-wrap><p>The purpose of these investigations was to make a comparison before and after surgery at the level of mandible (area of major interest in this study). The comparison was based on the parameters which resulted after the CT measurements on 150 relevant images for the study. A densitometry study was rolled out on these images. The animals were investigated at 1, 2 and 3 months. The bone density was measured in the mandibular region at the level of the insertion of the nanostructured hydroxyapatite.</p><p>The results are presented in the <bold><xref ref-type="table" rid="T3">Table 3</xref></bold>.</p><table-wrap id="T3" position="float"><label>Table 3</label><caption><p>Normal mandibular density preoperatively, and after 1, 2 and respectively 3 months after bone reconstruction</p></caption><table frame="hsides" rules="groups"><tbody><tr><td align="center" rowspan="1" colspan="1">Normal mandibular bone density </td><td align="center" rowspan="1" colspan="1">Bone density 1 month after the reconstruction with nanostructured hydroxyapatite </td><td align="center" rowspan="1" colspan="1">Bone density 2 months after the reconstruction with nanostructured hydroxyapatite</td><td align="center" rowspan="1" colspan="1">Bone density 3 months after the reconstruction with nanostructured hydroxyapatite</td></tr><tr><td align="center" rowspan="1" colspan="1">500-550 UH</td><td align="center" rowspan="1" colspan="1">200-300 UH</td><td align="center" rowspan="1" colspan="1">300-400UH</td><td align="center" rowspan="1" colspan="1">500-600UH</td></tr></tbody></table></table-wrap></sec><sec sec-type="Discussion" id="sec1-4"><title>Discussion</title><p>Bone density increased in time after the surgery and 3 months after the surgery it reached a density equal with the density of the healthy bone. The obtained results were similar in all animals in the experiment.</p><p>Although there was a large variety of biomaterials for bone reconstruction, this nanostructured hydroxyapatite could provide an excellent support for dental implants.</p></sec><sec sec-type="Conclusions" id="sec1-5"><title>Conclusions</title><p>The use of nanotechnology in dentistry means the use of innovative materials, materials that are tested or are in the process of testing.</p><p>The conversion of nanostructured hydroxyapatite into a bone graft biomaterial presents multiple advantages not only from the medical point of view but also from the environmental and economic ones. The main advantage is the natural origin of the material to be created. 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