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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">The Peripheral Giant Cell Granuloma in Edentulous Patients: Report of Three Unique Cases</title><author><name sortKey="Etoz, Osman A" sort="Etoz, Osman A" uniqKey="Etoz O" first="Osman A." last="Etoz">Osman A. Etoz</name><affiliation><nlm:aff id="af1-dent04_p0329">Erciyes University, Faculty of Dentistry, Department of Oral and Maxillofacial Surgery, Kayseri, Turkey.</nlm:aff></affiliation></author><author><name sortKey="Demirbas, Ahmet Emin" sort="Demirbas, Ahmet Emin" uniqKey="Demirbas A" first="Ahmet Emin" last="Demirbas">Ahmet Emin Demirbas</name><affiliation><nlm:aff id="af1-dent04_p0329">Erciyes University, Faculty of Dentistry, Department of Oral and Maxillofacial Surgery, Kayseri, Turkey.</nlm:aff></affiliation></author><author><name sortKey="Bulbul, Mehmet" sort="Bulbul, Mehmet" uniqKey="Bulbul M" first="Mehmet" last="Bulbul">Mehmet Bulbul</name><affiliation><nlm:aff id="af2-dent04_p0329">Gaziantep University, Faculty of Dentistry, Department of Prosthodontics, Gaziantep, Turkey.</nlm:aff></affiliation></author><author><name sortKey="Akay, Ebru" sort="Akay, Ebru" uniqKey="Akay E" first="Ebru" last="Akay">Ebru Akay</name><affiliation><nlm:aff id="af3-dent04_p0329"> Erciyes University, Faculty of Medicine, Department of Pathology, Kayseri Turkey.</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">20613923</idno><idno type="pmc">2897868</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2897868</idno><idno type="RBID">PMC:2897868</idno><date when="2010">2010</date><idno type="wicri:Area/Pmc/Corpus">001C76</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001C76</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">The Peripheral Giant Cell Granuloma in Edentulous Patients: Report of Three Unique Cases</title><author><name sortKey="Etoz, Osman A" sort="Etoz, Osman A" uniqKey="Etoz O" first="Osman A." last="Etoz">Osman A. Etoz</name><affiliation><nlm:aff id="af1-dent04_p0329">Erciyes University, Faculty of Dentistry, Department of Oral and Maxillofacial Surgery, Kayseri, Turkey.</nlm:aff></affiliation></author><author><name sortKey="Demirbas, Ahmet Emin" sort="Demirbas, Ahmet Emin" uniqKey="Demirbas A" first="Ahmet Emin" last="Demirbas">Ahmet Emin Demirbas</name><affiliation><nlm:aff id="af1-dent04_p0329">Erciyes University, Faculty of Dentistry, Department of Oral and Maxillofacial Surgery, Kayseri, Turkey.</nlm:aff></affiliation></author><author><name sortKey="Bulbul, Mehmet" sort="Bulbul, Mehmet" uniqKey="Bulbul M" first="Mehmet" last="Bulbul">Mehmet Bulbul</name><affiliation><nlm:aff id="af2-dent04_p0329">Gaziantep University, Faculty of Dentistry, Department of Prosthodontics, Gaziantep, Turkey.</nlm:aff></affiliation></author><author><name sortKey="Akay, Ebru" sort="Akay, Ebru" uniqKey="Akay E" first="Ebru" last="Akay">Ebru Akay</name><affiliation><nlm:aff id="af3-dent04_p0329"> Erciyes University, Faculty of Medicine, Department of Pathology, Kayseri Turkey.</nlm:aff></affiliation></author></analytic><series><title level="j">European Journal of Dentistry</title><idno type="ISSN">1305-7456</idno><idno type="eISSN">1305-7464</idno><imprint><date when="2010">2010</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>The peripheral giant cell granuloma (PGCG) is a rare reactive exophytic lesion taking place on the gingiva and alveolar ridge usually as a result of local irritating factors such as trauma, tooth extraction, badly finished fillings, unstable dental prosthesis, plaque, calculus, chronic infections, and impacted food. This article presents 3 cases of PGCG that presented at the same location of the edentulous mandible of patients that using complete denture for over ten years.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Duarte Ruiz, B" uniqKey="Duarte Ruiz B">B Duarte-Ruiz</name></author><author><name sortKey="Riba Garcia, Fa" uniqKey="Riba Garcia F">FA Riba-García</name></author><author><name sortKey="Navarro Cuellar, C" uniqKey="Navarro Cuellar C">C Navarro-Cuéllar</name></author><author><name sortKey="Bucci, T" uniqKey="Bucci T">T Bucci</name></author><author><name sortKey="Cuesta Gil, M" uniqKey="Cuesta Gil M">M Cuesta-Gil</name></author><author><name sortKey="Navarro Vila, C" uniqKey="Navarro Vila C">C Navarro-Vila</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gandara, Jm" uniqKey="Gandara J">JM Gándara</name></author><author><name sortKey="Pacheco, Jl" uniqKey="Pacheco J">JL Pacheco</name></author><author><name sortKey="Gandara, P" uniqKey="Gandara P">P Gándara</name></author><author><name sortKey="Blanco, A" uniqKey="Blanco A">A Blanco</name></author><author><name sortKey="Garcia, A" uniqKey="Garcia A">A García</name></author><author><name sortKey="Madri N, P" uniqKey="Madri N P">P Madriñán</name></author><author><name sortKey="Somoza, M" uniqKey="Somoza M">M Somoza</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chaparro Avenda O, Av" uniqKey="Chaparro Avenda O A">Av Chaparro-Avendaño</name></author><author><name sortKey="Berini Aytes, L" uniqKey="Berini Aytes L">L Berini-Aytés</name></author><author><name sortKey="Gay Escoda, C" uniqKey="Gay Escoda C">C Gay Escoda</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bodner, Lipa" uniqKey="Bodner L">Lipa Bodner</name></author><author><name sortKey="Peist, Mauricio" uniqKey="Peist M">Mauricio Peist</name></author><author><name sortKey="Gatot, Albert" uniqKey="Gatot A">Albert Gatot</name></author><author><name sortKey="Fliss, Dan M" uniqKey="Fliss D">Dan M Fliss</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Katsikeris, N" uniqKey="Katsikeris N">N Katsikeris</name></author><author><name sortKey="Kakarantza Angelopoulou, E" uniqKey="Kakarantza Angelopoulou E">E Kakarantza-Angelopoulou</name></author><author><name sortKey="Angelopoulos, Ap" uniqKey="Angelopoulos A">AP Angelopoulos</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Shafer, Wg" uniqKey="Shafer W">WG Shafer</name></author><author><name sortKey="Hine, Mk" uniqKey="Hine M">MK Hine</name></author><author><name sortKey="Levy, Bm" uniqKey="Levy B">BM Levy</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Motamedi, Mh" uniqKey="Motamedi M">MH Motamedi</name></author><author><name sortKey="Eshghyar, N" uniqKey="Eshghyar N">N Eshghyar</name></author><author><name sortKey="Jafari, Sm" uniqKey="Jafari S">SM Jafari</name></author><author><name sortKey="Lassemi, E" uniqKey="Lassemi E">E Lassemi</name></author><author><name sortKey="Navi, F" uniqKey="Navi F">F Navi</name></author><author><name sortKey="Abbas, Fm" uniqKey="Abbas F">FM Abbas</name></author><author><name sortKey="Khalifeh, S" uniqKey="Khalifeh S">S Khalifeh</name></author><author><name sortKey="Eshkevari, Ps" uniqKey="Eshkevari P">PS Eshkevari</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Flaitz, Cm" uniqKey="Flaitz C">CM Flaitz</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Grand, E" uniqKey="Grand E">E Grand</name></author><author><name sortKey="Burgener, E" uniqKey="Burgener E">E Burgener</name></author><author><name sortKey="Samson, J" uniqKey="Samson J">J Samson</name></author><author><name sortKey="Lombardi, T" uniqKey="Lombardi T">T Lombardi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kfir, Y" uniqKey="Kfir Y">Y Kfir</name></author><author><name sortKey="Buchner, A" uniqKey="Buchner A">A Buchner</name></author><author><name sortKey="Hansen, Ls" uniqKey="Hansen L">LS Hansen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Anneroth, G" uniqKey="Anneroth G">G Anneroth</name></author><author><name sortKey="Sigurdson, A" uniqKey="Sigurdson A">A Sigurdson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bodner, L" uniqKey="Bodner L">L Bodner</name></author><author><name sortKey="Dayan, D" uniqKey="Dayan D">D Dayan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dayan, D" uniqKey="Dayan D">D Dayan</name></author><author><name sortKey="Buchner, A" uniqKey="Buchner A">A Buchner</name></author><author><name sortKey="Spirer, S" uniqKey="Spirer S">S Spirer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lucas, Rb" uniqKey="Lucas R">RB Lucas</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mighell, Aj" uniqKey="Mighell A">AJ Mighell</name></author><author><name sortKey="Robinson, Pa" uniqKey="Robinson P">PA Robinson</name></author><author><name sortKey="Hume, Wj" uniqKey="Hume W">WJ Hume</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Aeron, H" uniqKey="Aeron H">H Aeron</name></author><author><name sortKey="Fenton, A" uniqKey="Fenton A">A Fenton</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Budtz Jorgensen, Ejving" uniqKey="Budtz Jorgensen E">Ejving Budtz-Jorgensen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hickey, Jc" uniqKey="Hickey J">JC Hickey</name></author><author><name sortKey="Zarb, Ga" uniqKey="Zarb G">GA Zarb</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ansari, Ih" uniqKey="Ansari I">IH Ansari</name></author></analytic></biblStruct></listBibl></div1></back></TEI><pmc article-type="case-report"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Eur J Dent</journal-id><journal-id journal-id-type="publisher-id">Eur J Dent</journal-id><journal-title-group><journal-title>European Journal of Dentistry</journal-title></journal-title-group><issn pub-type="ppub">1305-7456</issn><issn pub-type="epub">1305-7464</issn><publisher><publisher-name>Dental Investigations Society</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">20613923</article-id><article-id pub-id-type="pmc">2897868</article-id><article-id pub-id-type="publisher-id">dent04_p0329</article-id><article-categories><subj-group subj-group-type="heading"><subject>Case Reports</subject></subj-group></article-categories><title-group><article-title>The Peripheral Giant Cell Granuloma in Edentulous Patients: Report of Three Unique Cases</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Etoz</surname><given-names>Osman A.</given-names></name><xref ref-type="aff" rid="af1-dent04_p0329">a</xref></contrib><contrib contrib-type="author"><name><surname>Demirbas</surname><given-names>Ahmet Emin</given-names></name><xref ref-type="aff" rid="af1-dent04_p0329">a</xref></contrib><contrib contrib-type="author"><name><surname>Bulbul</surname><given-names>Mehmet</given-names></name><xref ref-type="corresp" rid="c1-dent04_p0329"></xref><xref ref-type="aff" rid="af2-dent04_p0329">b</xref></contrib><contrib contrib-type="author"><name><surname>Akay</surname><given-names>Ebru</given-names></name><xref ref-type="aff" rid="af3-dent04_p0329">c</xref></contrib></contrib-group><aff id="af1-dent04_p0329"><label>a</label>Erciyes University, Faculty of Dentistry, Department of Oral and Maxillofacial Surgery, Kayseri, Turkey.</aff><aff id="af2-dent04_p0329"><label>b</label>Gaziantep University, Faculty of Dentistry, Department of Prosthodontics, Gaziantep, Turkey.</aff><aff id="af3-dent04_p0329"><label>c</label> Erciyes University, Faculty of Medicine, Department of Pathology, Kayseri Turkey.</aff><author-notes><corresp id="c1-dent04_p0329">Corresponding author: Dr. Mehmet Bulbul, Gaziantep Universitesi, Dishekimligi Fakultesi, Protetik Dis Tedavisi Anabilim Dali, Kampus, Gaziantep, Turkey. E-mail:
<email>mbulbul@gantep.edu.tr</email></corresp></author-notes><pub-date pub-type="ppub"><month>7</month><year>2010</year></pub-date><volume>4</volume><issue>3</issue><fpage>329</fpage><lpage>333</lpage><permissions><copyright-statement>Copyright 2010 European Journal of Dentistry. All rights reserved.</copyright-statement></permissions><abstract><p>The peripheral giant cell granuloma (PGCG) is a rare reactive exophytic lesion taking place on the gingiva and alveolar ridge usually as a result of local irritating factors such as trauma, tooth extraction, badly finished fillings, unstable dental prosthesis, plaque, calculus, chronic infections, and impacted food. This article presents 3 cases of PGCG that presented at the same location of the edentulous mandible of patients that using complete denture for over ten years.</p></abstract><kwd-group><kwd>Peripheral giant cell granuloma</kwd><kwd>Chronic irritation</kwd><kwd>Edentulous patients</kwd><kwd>Complete denture</kwd></kwd-group></article-meta></front><body><sec sec-type="intro"><title>INTRODUCTION</title><p>Giant cell granuloma lesions (peripheral and central) are benign, non-odontogenic, moderately rare tumors of the oral cavity. They develop peripherally (within gingiva) or centrally (in bone).<xref ref-type="bibr" rid="b1-dent04_p0329">1</xref> The peripheral giant cell granuloma (PGCG) is a rare reactive exophytic lesion taking place on the gingiva and alveolar ridge, also known as a giant-cell epulis, giant-cell reparative granuloma, osteoclastoma, or giant-cell hyperplasia. Etiologic factors are not known, although it is thought that it may be due to an irritant or aggressive factor such as trauma, tooth extraction, badly finished fillings, unstable dental prosthesis, plaque, calculus, chronic infections, or impacted food.<xref ref-type="bibr" rid="b2-dent04_p0329">2</xref>,<xref ref-type="bibr" rid="b3-dent04_p0329">3</xref> Clinical appearance of PGCGs can present as polyploidy or nodular lesions, primarily bluish red with a smooth shiny or mamillated surface, stalky or sessile base, small and well demarcated.<xref ref-type="bibr" rid="b2-dent04_p0329">2</xref>,<xref ref-type="bibr" rid="b4-dent04_p0329">4</xref>,<xref ref-type="bibr" rid="b5-dent04_p0329">5</xref> Pain is rare and in most cases growth of the lesion is induced by constant trauma.<xref ref-type="bibr" rid="b3-dent04_p0329">3</xref> PGCGs usually originate from either the periodontal ligament or mucoperiosteum. The PGCG is located in the region of the gingiva or edentulous alveolar margins, frequently in the lower jaw.<xref ref-type="bibr" rid="b3-dent04_p0329">3</xref> Histological features of PGCG reveal a non-capsulated mass of tissue containing a large number of young connective tissue cells and multinucleated giant cells.<xref ref-type="bibr" rid="b4-dent04_p0329">4</xref> Hemorrhage, hemosiderin, inflammatory cells, and newly formed bone or calcified material may also be seen throughout the cellular connective tissue.<xref ref-type="bibr" rid="b5-dent04_p0329">5</xref>,<xref ref-type="bibr" rid="b6-dent04_p0329">6</xref> The lesion can develop at any age, though it is more common between the fifth and sixth decades of life, and shows a slight female predilection.<xref ref-type="bibr" rid="b4-dent04_p0329">4</xref>–<xref ref-type="bibr" rid="b7-dent04_p0329">7</xref> PGCG is a soft tissue lesion that infrequently affects the underlying bone, although the latter may undergo superficial erosion.<xref ref-type="bibr" rid="b3-dent04_p0329">3</xref>,<xref ref-type="bibr" rid="b7-dent04_p0329">7</xref>,<xref ref-type="bibr" rid="b8-dent04_p0329">8</xref> In the present report, three cases of PGCG are presented at the same location in the mandible.</p></sec><sec sec-type="cases"><title>CASE REPORTS</title><sec><title>Case 1</title><p>A 57-year-old otherwise healthy woman was referred to our clinic for a gingival mass of the lower jaw. The patient was edentulous and had been using a complete denture for more than 10 years. The tumoral lesion was located on the edentulous anterior mandible, and the patient did not know how long the lesion had been there. The patient reported neither pain nor alteration of the size of the mass. Clinical exploration revealed a red and bluish nodule, sessile lesion located on the anterior mandibular alveolar crest (<xref ref-type="fig" rid="f1-dent04_p0329">Figure 1</xref>). The lesion measured 1x0.5 cm in size and had no ulcerated surface. Radiological examination revealed no evidence of bony involvement. Treatment consisted of resection of the lesion and closure of the defect with a mucosal graft. Postoperative healing was uneventful (<xref ref-type="fig" rid="f2-dent04_p0329">Figure 2</xref>) and no sign of recurrence was observed. Histopathological examination of the lesion revealed rich inflammatory cell infiltration under the epithelia, a great number of multinuclear giant cells between the inflammatory cells, and epithelioid histiocytes around the inflammatory cells. Also there were many congestive vessels, hemorrhages, and hemosiderin over the cellular connective tissue. Final diagnosis was made as PGCG.</p></sec><sec><title>Case 2</title><p>A 81-year-old female patient with hypertension was referred to our clinic for soft swelling on the anterior mandible. The patient was edentulous and had been using a complete denture for about 15 years. The lesion had appeared one month before. The patient reported neither pain nor alteration of the size of the mass. Clinical exploration revealed a red-bluish nodule, sessile lesion located on the anterior mandibular alveolar crest (<xref ref-type="fig" rid="f3-dent04_p0329">Figure 3</xref>). The lesion measured 1x0.5 cm in size and had no ulcerated surface. Radiological examination showed no evidence of bony involvement.</p><p>Treatment consisted of resection of the lesion and closure of the defect with a mucosal graft. Postoperative healing was uneventful (<xref ref-type="fig" rid="f4-dent04_p0329">Figure 4</xref>). Histopathological examination confirmed the diagnosis of PGCG (<xref ref-type="fig" rid="f5-dent04_p0329">Figure 5</xref>). Through the one-year follow-up period, there were no complaints or recurrences.</p></sec><sec><title>Case 3</title><p>A 53-year-old otherwise healthy male patient was edentulous and had been using a complete denture for more than 10 years. The patient reported a painless lesion at the anterior mandible which had grown in size in the last few months. Clinical examination revealed a red-bluish nodule, sessile lesion located on the anterior mandibular alveolar crest (<xref ref-type="fig" rid="f6-dent04_p0329">Figure 6</xref>). The lesion measured 1x0.5 cm in size and had no ulcerated surface. Radiological exploration showed no evidence of bony involvement. The lesion was resected and the wound was closed with a mucosal graft. Postoperative healing was uneventful (<xref ref-type="fig" rid="f7-dent04_p0329">Figure 7</xref>). Histopathological examination confirmed the diagnosis of PGCG (<xref ref-type="fig" rid="f8-dent04_p0329">Figures 8</xref> and <xref ref-type="fig" rid="f9-dent04_p0329">9</xref>). Through the one-year follow-up period, there were no complaints or recurrences.</p></sec></sec><sec sec-type="discussion"><title>DISCUSSION</title><p>Peripheral giant cell granuloma (PGCG) is a benign hyperplastic reactive lesion which is a relatively uncommon lesion of the oral mucosa. PGCG originates from the periodontal ligament or mucoperiosteum and is usually caused by local irritation or chronic trauma. The etiology of PGCG is unknown. Local irritation factors such as poor dental restorations, unstable dental prosthesis, dental extractions, plaque and calculus accumulation, and food retention seem to play a significant role in the development of a PGCG.<xref ref-type="bibr" rid="b2-dent04_p0329">2</xref>,<xref ref-type="bibr" rid="b3-dent04_p0329">3</xref>,<xref ref-type="bibr" rid="b5-dent04_p0329">5</xref>,<xref ref-type="bibr" rid="b9-dent04_p0329">9</xref>–<xref ref-type="bibr" rid="b11-dent04_p0329">11</xref> Histopathologic characteristics of PGCG may be consistent with periodontal ligament or periosteum origin.<xref ref-type="bibr" rid="b4-dent04_p0329">4</xref> Histologically, PGCG is identified as a non-encapsulated mass of tissue compiled of a reticular and fibrillar connective tissue stroma containing profuse young connective tissue cells of ovoid or fusiform shape, and multinucleated giant cells.<xref ref-type="bibr" rid="b8-dent04_p0329">8</xref> The fibrocellular reaction is akin to that of other reactive lesions such as fibrous hyperplasia and peripheral ossifying fibroma.<xref ref-type="bibr" rid="b10-dent04_p0329">10</xref>–<xref ref-type="bibr" rid="b12-dent04_p0329">12</xref> The calcified material or newly formed bone may also be seen all over the cellular connective tissue, and some of the lesions may be either woven bone or lamellar bone produced by the mononuclear stromal cells, which might be similar to latent proliferative osteoblasts or osteoprogenitor cells.<xref ref-type="bibr" rid="b5-dent04_p0329">5</xref>,<xref ref-type="bibr" rid="b6-dent04_p0329">6</xref>,<xref ref-type="bibr" rid="b13-dent04_p0329">13</xref> The microscopic appearance of PGCG is distinctive mainly due to the large number of multinucleated giant cells that are disseminated in the connective tissue stroma.<xref ref-type="bibr" rid="b4-dent04_p0329">4</xref> The exact basis of the giant cells is still uncertain. Many opinions have been offered in the literature, as osteoblasts, phagocytes, endothelial cells, and spindle cells are thought to be responsible for giant cell proliferation.<xref ref-type="bibr" rid="b6-dent04_p0329">6</xref>,<xref ref-type="bibr" rid="b14-dent04_p0329">14</xref> The widely reported discrepancy in the gender ratio may mirror the small number of cases considered in some series, but the majority of studies agree that there is a female predominance.<xref ref-type="bibr" rid="b15-dent04_p0329">15</xref> In this report, two of our three patients were female. PGCG is seen in almost every decade group, but most patients were aged between four and seven decades, as reported in previous studies.<xref ref-type="bibr" rid="b4-dent04_p0329">4</xref>,<xref ref-type="bibr" rid="b5-dent04_p0329">5</xref>,<xref ref-type="bibr" rid="b7-dent04_p0329">7</xref> Two of our patients were in the five-decade age cohort and one patient was in the eighth decade. The affected site for all patients in this report was the anterior mandible. In the literature, PGCG is more common in the lower jaw than in the upper jaw.<xref ref-type="bibr" rid="b4-dent04_p0329">4</xref>,<xref ref-type="bibr" rid="b5-dent04_p0329">5</xref> Clinically, PGCG is a smooth brown, red, or bluish nodule, sessile or pedunculated. Radiographic examinations generally have no findings, because the lesion is a soft tissue mass. Although the etiology of PGCG is unclear, in the present report the etiologic factor is thought to be chronic trauma, because of unstable prosthesis. Our three patients have used complete dentures for numerous years. PGCGs generally develop either in the gingival tissue or in the alveolar processes of the incisor and canine region.<xref ref-type="bibr" rid="b3-dent04_p0329">3</xref> Of our three cases, all were located in the edentulous alveolar margins of the anterior mandibular region. Lesion size differs from 0.5 to 1.5 cm in diameter, although there have been 5 cm size cases in the literature, in which factors such as poor oral hygiene or xerostomia seem to play an important role in lesion growth.<xref ref-type="bibr" rid="b4-dent04_p0329">4</xref> None of our cases exceeded 2 cm in size.</p><p>In the present report, all three cases have had long-term use of complete dentures that might be thought of as having the possible effect of unstable dental prostheses on PGCGs etiology. The most preferred occlusion type for complete dentures is bilateral balanced occlusion (BBO). In BBO, the anterior teeth do not make contact during functional movements (<xref ref-type="fig" rid="f10-dent04_p0329">Figure 10</xref>).<xref ref-type="bibr" rid="b16-dent04_p0329">16</xref> Over time, as a result of posterior denture erosion, anterior teeth may contact.<xref ref-type="bibr" rid="b17-dent04_p0329">17</xref> These contacts may cause resorption on residual ridges and so soft tissues can lose bone support and, after all these changes, increased forces may create irritation on these areas.<xref ref-type="bibr" rid="b16-dent04_p0329">16</xref>,<xref ref-type="bibr" rid="b18-dent04_p0329">18</xref>,<xref ref-type="bibr" rid="b19-dent04_p0329">19</xref> This may be an irritant factor for PGCG development. Edentulous patients wearing complete dentures should be followed up at one-year intervals and should be considered for implant-supported dentures to prevent soft tissue trauma. Complete dentures should be re-fabricated every five years even for asymptomatic cases in order to avoid possible development of reactive lesions such as PGCG.</p></sec></body><back><ref-list><title>REFERENCES</title><ref id="b1-dent04_p0329"><label>1.</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Duarte-Ruiz</surname><given-names>B</given-names></name><name><surname>Riba-García</surname><given-names>FA</given-names></name><name><surname>Navarro-Cuéllar</surname><given-names>C</given-names></name><name><surname>Bucci</surname><given-names>T</given-names></name><name><surname>Cuesta-Gil</surname><given-names>M</given-names></name><name><surname>Navarro-Vila</surname><given-names>C</given-names></name></person-group><article-title>Reparative giant cell granuloma in a pediatric patient</article-title><source>Med Oral Patol Oral Cir Bucal</source><year>2007</year><volume>12</volume><fpage>E331</fpage><lpage>E335</lpage><pub-id pub-id-type="pmid">17664921</pub-id></mixed-citation></ref><ref id="b2-dent04_p0329"><label>2.</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Gándara</surname><given-names>JM</given-names></name><name><surname>Pacheco</surname><given-names>JL</given-names></name><name><surname>Gándara</surname><given-names>P</given-names></name><name><surname>Blanco</surname><given-names>A</given-names></name><name><surname>García</surname><given-names>A</given-names></name><name><surname>Madriñán</surname><given-names>P</given-names></name><name><surname>Somoza</surname><given-names>M</given-names></name></person-group><article-title>Granuloma periférico de células gigantes. Revisión de 13 casos clínicos</article-title><source>Medicina Oral</source><year>2002</year><volume>7</volume><fpage>254</fpage><lpage>259</lpage><pub-id pub-id-type="pmid">12134126</pub-id></mixed-citation></ref><ref id="b3-dent04_p0329"><label>3.</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Chaparro-Avendaño</surname><given-names>Av</given-names></name><name><surname>Berini-Aytés</surname><given-names>L</given-names></name><name><surname>Gay Escoda</surname><given-names>C</given-names></name></person-group><article-title>Peripheral giant cell granuloma. A report of five cases and review of the literature</article-title><source>Med Oral Patol Oral Cir Bucal</source><year>2005</year><volume>10</volume><fpage>48</fpage><lpage>57</lpage></mixed-citation></ref><ref id="b4-dent04_p0329"><label>4.</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Bodner</surname><given-names>Lipa</given-names></name><name><surname>Peist</surname><given-names>Mauricio</given-names></name><name><surname>Gatot</surname><given-names>Albert</given-names></name><name><surname>Fliss</surname><given-names>Dan M</given-names></name></person-group><article-title>Growth potential of peripheral giant cell granuloma</article-title><source>Oral Surg Oral Med Oral Pathol Oral Radiol Endod</source><year>1997</year><volume>83</volume><fpage>548</fpage><lpage>551</lpage><pub-id pub-id-type="pmid">9159813</pub-id></mixed-citation></ref><ref id="b5-dent04_p0329"><label>5.</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Katsikeris</surname><given-names>N</given-names></name><name><surname>Kakarantza-Angelopoulou</surname><given-names>E</given-names></name><name><surname>Angelopoulos</surname><given-names>AP</given-names></name></person-group><article-title>Peripheral giant cell granuloma: clinicopathologic study of 224 new cases and review of 956 reported cases</article-title><source>Int J Oral Maxillofac Surg</source><year>1988</year><volume>17</volume><fpage>94</fpage><lpage>99</lpage><pub-id pub-id-type="pmid">3133432</pub-id></mixed-citation></ref><ref id="b6-dent04_p0329"><label>6.</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Shafer</surname><given-names>WG</given-names></name><name><surname>Hine</surname><given-names>MK</given-names></name><name><surname>Levy</surname><given-names>BM</given-names></name></person-group><article-title>A textbook of oral pathol</article-title><edition>4th ed</edition><source>Philadelphia: WB Saunders</source><year>1983</year><fpage>144</fpage><lpage>146</lpage></mixed-citation></ref><ref id="b7-dent04_p0329"><label>7.</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Motamedi</surname><given-names>MH</given-names></name><name><surname>Eshghyar</surname><given-names>N</given-names></name><name><surname>Jafari</surname><given-names>SM</given-names></name><name><surname>Lassemi</surname><given-names>E</given-names></name><name><surname>Navi</surname><given-names>F</given-names></name><name><surname>Abbas</surname><given-names>FM</given-names></name><name><surname>Khalifeh</surname><given-names>S</given-names></name><name><surname>Eshkevari</surname><given-names>PS</given-names></name></person-group><article-title>Peripheral and central giant cell granulomas of the jaws: A demographic study</article-title><source>Oral Surg Oral Med Oral Pathol Oral Radiol Endod</source><year>2007</year><volume>103</volume><fpage>e39</fpage><lpage>e43</lpage><pub-id pub-id-type="pmid">17428697</pub-id></mixed-citation></ref><ref id="b8-dent04_p0329"><label>8.</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Flaitz</surname><given-names>CM</given-names></name></person-group><article-title>Peripheral giant cell granuloma: a potentially aggressive lesion in children</article-title><source>Pediatr Dent</source><year>2000</year><volume>22</volume><fpage>232</fpage><lpage>233</lpage><pub-id pub-id-type="pmid">10846736</pub-id></mixed-citation></ref><ref id="b9-dent04_p0329"><label>9.</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Grand</surname><given-names>E</given-names></name><name><surname>Burgener</surname><given-names>E</given-names></name><name><surname>Samson</surname><given-names>J</given-names></name><name><surname>Lombardi</surname><given-names>T</given-names></name></person-group><article-title>Post-traumatic development of a peripheral giant cell granuloma in a child</article-title><source>Dental Traumatol</source><year>2008</year><volume>24</volume><fpage>124</fpage><lpage>126</lpage></mixed-citation></ref><ref id="b10-dent04_p0329"><label>10.</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Kfir</surname><given-names>Y</given-names></name><name><surname>Buchner</surname><given-names>A</given-names></name><name><surname>Hansen</surname><given-names>LS</given-names></name></person-group><article-title>Reactive lesions of the gingiva. A clinicopathological study of 741 cases</article-title><source>J Periodontol</source><year>1980</year><volume>51</volume><fpage>655</fpage><lpage>661</lpage><pub-id pub-id-type="pmid">6936553</pub-id></mixed-citation></ref><ref id="b11-dent04_p0329"><label>11.</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Anneroth</surname><given-names>G</given-names></name><name><surname>Sigurdson</surname><given-names>A</given-names></name></person-group><article-title>Hyperplastic lesions of the gingiva and alveolar mucosa. A study of 175 cases</article-title><source>Acta Odontol Scand</source><year>1983</year><volume>1</volume><fpage>75</fpage><lpage>86</lpage><pub-id pub-id-type="pmid">6576600</pub-id></mixed-citation></ref><ref id="b12-dent04_p0329"><label>12.</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Bodner</surname><given-names>L</given-names></name><name><surname>Dayan</surname><given-names>D</given-names></name></person-group><article-title>Growth potential of peripheral ossifying fibroma</article-title><source>J Clin Periodontol</source><year>1987</year><volume>14</volume><fpage>551</fpage><lpage>554</lpage><pub-id pub-id-type="pmid">3479457</pub-id></mixed-citation></ref><ref id="b13-dent04_p0329"><label>13.</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Dayan</surname><given-names>D</given-names></name><name><surname>Buchner</surname><given-names>A</given-names></name><name><surname>Spirer</surname><given-names>S</given-names></name></person-group><article-title>Bone formation in peripheral giant cell granuloma</article-title><source>J Periodontol</source><year>1990</year><volume>61</volume><fpage>444</fpage><lpage>446</lpage><pub-id pub-id-type="pmid">2117655</pub-id></mixed-citation></ref><ref id="b14-dent04_p0329"><label>14.</label><mixed-citation publication-type="book"><person-group person-group-type="author"><name><surname>Lucas</surname><given-names>RB</given-names></name></person-group><source>Pathology of tumors of the oral tissues</source><edition>4th ed</edition><publisher-loc>London</publisher-loc><publisher-name>Churchill Livingstone</publisher-name><year>1984</year><fpage>259</fpage><lpage>272</lpage></mixed-citation></ref><ref id="b15-dent04_p0329"><label>15.</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Mighell</surname><given-names>AJ</given-names></name><name><surname>Robinson</surname><given-names>PA</given-names></name><name><surname>Hume</surname><given-names>WJ</given-names></name></person-group><article-title>Peripheral giant cell granuloma: a clinical study of 77 cases from 62 patients, and literature review</article-title><source>Oral Diseases</source><year>1995</year><volume>1</volume><fpage>12</fpage><lpage>19</lpage><pub-id pub-id-type="pmid">7553374</pub-id></mixed-citation></ref><ref id="b16-dent04_p0329"><label>16.</label><mixed-citation publication-type="book"><person-group person-group-type="author"><name><surname>Aeron</surname><given-names>H</given-names></name><name><surname>Fenton</surname><given-names>A</given-names></name></person-group><article-title>Selecting and arranging prosthetic teeth and occlusion for the edentulous patient</article-title><person-group person-group-type="editor"><name><surname>Zarb</surname><given-names>George A</given-names></name><name><surname>Bolender</surname><given-names>Charles L</given-names></name></person-group><source>Prosthodontic treatment for edentulous patients</source><publisher-name>Mosby</publisher-name><publisher-loc>St. Louis, MO, USA</publisher-loc><year>2004</year><fpage>298</fpage><lpage>328</lpage></mixed-citation></ref><ref id="b17-dent04_p0329"><label>17.</label><mixed-citation publication-type="book"><person-group person-group-type="author"><name><surname>Budtz-Jorgensen</surname><given-names>Ejving</given-names></name></person-group><source>Prosthodontics for the elderly</source><publisher-name>Quintessence</publisher-name><publisher-loc>Publishing co. Illinois, USA</publisher-loc><year>1999</year><fpage>203</fpage><lpage>228</lpage></mixed-citation></ref><ref id="b18-dent04_p0329"><label>18.</label><mixed-citation publication-type="book"><person-group person-group-type="author"><name><surname>Hickey</surname><given-names>JC</given-names></name><name><surname>Zarb</surname><given-names>GA</given-names></name></person-group><source>Boucher's prosthodontic treatment for edentulous patients</source><edition>8th ed</edition><publisher-loc>St Louis</publisher-loc><publisher-name>CV Mosby</publisher-name><year>1980</year><fpage>455</fpage><lpage>479</lpage></mixed-citation></ref><ref id="b19-dent04_p0329"><label>19.</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Ansari</surname><given-names>IH</given-names></name></person-group><article-title>Simplified clinical remount for complete dentures</article-title><source>J Prosthet Dent</source><year>1996</year><volume>76</volume><fpage>321</fpage><lpage>324</lpage><pub-id pub-id-type="pmid">8887808</pub-id></mixed-citation></ref></ref-list></back><floats-group><fig id="f1-dent04_p0329" position="float"><label>Figure 1.</label><caption><p>Clinical view of the lesion of the first patient.</p></caption><graphic xlink:href="DENT-4-330-g1"></graphic></fig><fig id="f2-dent04_p0329" position="float"><label>Figure 2.</label><caption><p>Clinical view of the postoperative healing of the first patient.</p></caption><graphic xlink:href="DENT-4-330-g2"></graphic></fig><fig id="f3-dent04_p0329" position="float"><label>Figure 3.</label><caption><p>Clinical view of the lesion of the second patient.</p></caption><graphic xlink:href="DENT-4-330-g3"></graphic></fig><fig id="f4-dent04_p0329" position="float"><label>Figure 4.</label><caption><p>Clinical view of the postoperative healing of the second patient.</p></caption><graphic xlink:href="DENT-4-331-g4"></graphic></fig><fig id="f5-dent04_p0329" position="float"><label>Figure 5.</label><caption><p>Histopathological view of the lesion of the second patient (A- hematoxylin eosin X40).</p></caption><graphic xlink:href="DENT-4-331-g5"></graphic></fig><fig id="f6-dent04_p0329" position="float"><label>Figure 6.</label><caption><p>Clinical view of the lesion of the third patient.</p></caption><graphic xlink:href="DENT-4-331-g6"></graphic></fig><fig id="f7-dent04_p0329" position="float"><label>Figure 7.</label><caption><p>Clinical view of the postoperative healing of the third patient.</p></caption><graphic xlink:href="DENT-4-331-g7"></graphic></fig><fig id="f8-dent04_p0329" position="float"><label>Figure 8.</label><caption><p>Histopathological view of the lesion of the third patient (hematoxylin eosin X40).</p></caption><graphic xlink:href="DENT-4-331-g8"></graphic></fig><fig id="f9-dent04_p0329" position="float"><label>Figure 9.</label><caption><p>Histopathological view of the lesion of the third patient (hematoxylin eosin X200).</p></caption><graphic xlink:href="DENT-4-331-g9"></graphic></fig><fig id="f10-dent04_p0329" position="float"><label>Figure 10.</label><caption><p>Clinical view of the post prothetic treatment of first patient.</p></caption><graphic xlink:href="DENT-4-332-g10"></graphic></fig></floats-group></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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