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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Management of an unusual peripheral giant cell granuloma: A diagnostic dilemma</title><author><name sortKey="Mannem, Satheesh" sort="Mannem, Satheesh" uniqKey="Mannem S" first="Satheesh" last="Mannem">Satheesh Mannem</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Chava, Vijay K" sort="Chava, Vijay K" uniqKey="Chava V" first="Vijay K." last="Chava">Vijay K. Chava</name><affiliation><nlm:aff id="aff2"><italic>Department of Periodontics, Narayana Dental College and Hospital, Nellore, Andhra Pradesh, India</italic></nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">22557907</idno><idno type="pmc">3341770</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3341770</idno><idno type="RBID">PMC:3341770</idno><idno type="doi">10.4103/0976-237X.94556</idno><date when="2012">2012</date><idno type="wicri:Area/Pmc/Corpus">001B91</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001B91</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Management of an unusual peripheral giant cell granuloma: A diagnostic dilemma</title><author><name sortKey="Mannem, Satheesh" sort="Mannem, Satheesh" uniqKey="Mannem S" first="Satheesh" last="Mannem">Satheesh Mannem</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Chava, Vijay K" sort="Chava, Vijay K" uniqKey="Chava V" first="Vijay K." last="Chava">Vijay K. Chava</name><affiliation><nlm:aff id="aff2"><italic>Department of Periodontics, Narayana Dental College and Hospital, Nellore, Andhra Pradesh, India</italic></nlm:aff></affiliation></author></analytic><series><title level="j">Contemporary Clinical Dentistry</title><idno type="ISSN">0976-237X</idno><idno type="eISSN">0976-2361</idno><imprint><date when="2012">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>The peripheral giant cell granuloma (PGCG) is a reactive exophytic lesion of the gingiva and alveolar ridge that usually occurs as a result of local irritating factors such as plaque, calculus, chronic infections, chronic irritation, tooth extraction, improperly finished fillings, unstable dental prosthesis, and impacted food which originates from the periosteum or periodontal ligament. This article presents management of an unusual PGCG located on the partially edentulous mandible.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Katsikeris, N" uniqKey="Katsikeris N">N Katsikeris</name></author><author><name sortKey="Kakarantza Angelopoulou, E" uniqKey="Kakarantza Angelopoulou E">E Kakarantza-Angelopoulou</name></author><author><name sortKey="Angelopoulos, Ap" uniqKey="Angelopoulos A">AP Angelopoulos</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bodner, L" uniqKey="Bodner L">L Bodner</name></author><author><name sortKey="Peist, M" uniqKey="Peist M">M Peist</name></author><author><name sortKey="Gatot, A" uniqKey="Gatot A">A Gatot</name></author><author><name sortKey="Fliss, Dm" uniqKey="Fliss D">DM Fliss</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Shafer, Wg" uniqKey="Shafer W">WG Shafer</name></author><author><name sortKey="Hine, Mk" uniqKey="Hine M">MK Hine</name></author><author><name sortKey="Levy, Bm" uniqKey="Levy B">BM Levy</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Motamedi, Mh" uniqKey="Motamedi M">MH Motamedi</name></author><author><name sortKey="Eshghyar, N" uniqKey="Eshghyar N">N Eshghyar</name></author><author><name sortKey="Jafari, Sm" uniqKey="Jafari S">SM Jafari</name></author><author><name sortKey="Lassemi, E" uniqKey="Lassemi E">E Lassemi</name></author><author><name sortKey="Navi, F" uniqKey="Navi F">F Navi</name></author><author><name sortKey="Abbas, Fm" uniqKey="Abbas F">FM Abbas</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Anneroth, G" uniqKey="Anneroth G">G Anneroth</name></author><author><name sortKey="Sigurdson, A" uniqKey="Sigurdson A">A Sigurdson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Grand, E" uniqKey="Grand E">E Grand</name></author><author><name sortKey="Burgener, E" uniqKey="Burgener E">E Burgener</name></author><author><name sortKey="Samson, J" uniqKey="Samson J">J Samson</name></author><author><name sortKey="Lombardi, T" uniqKey="Lombardi T">T Lombardi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kfir, Y" uniqKey="Kfir Y">Y Kfir</name></author><author><name sortKey="Buchner, A" uniqKey="Buchner A">A Buchner</name></author><author><name sortKey="Hansen, Ls" uniqKey="Hansen L">LS Hansen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Etoz, Oa" uniqKey="Etoz O">OA Etoz</name></author><author><name sortKey="Demirbas, Ae" uniqKey="Demirbas A">AE Demirbas</name></author><author><name sortKey="Bulbul, M" uniqKey="Bulbul M">M Bulbul</name></author><author><name sortKey="Akay, E" uniqKey="Akay E">E Akay</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chaparro Avendano, Av" uniqKey="Chaparro Avendano A">Av Chaparro-Avendano</name></author><author><name sortKey="Berini Aytes, L" uniqKey="Berini Aytes L">L Berini-Aytes</name></author><author><name sortKey="Escoda, C Gay" uniqKey="Escoda C">C Gay Escoda</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bansal, P" uniqKey="Bansal P">P Bansal</name></author><author><name sortKey="Rohatgi, S" uniqKey="Rohatgi S">S Rohatgi</name></author><author><name sortKey="Agnihothri, A" uniqKey="Agnihothri A">A Agnihothri</name></author><author><name sortKey="Guptha, A" uniqKey="Guptha A">A Guptha</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gandara, Jm" uniqKey="Gandara J">JM Gandara</name></author><author><name sortKey="Pacheco, Jl" uniqKey="Pacheco J">JL Pacheco</name></author><author><name sortKey="Gandara, P" uniqKey="Gandara P">P Gándara</name></author><author><name sortKey="Blanco, A" uniqKey="Blanco A">A Blanco</name></author><author><name sortKey="Garcia, A" uniqKey="Garcia A">A García</name></author><author><name sortKey="Madri N, P" uniqKey="Madri N P">P Madriñán</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Flaitz, Cm" uniqKey="Flaitz C">CM Flaitz</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wood, Nk" uniqKey="Wood N">NK Wood</name></author><author><name sortKey="Goaz, Pw" uniqKey="Goaz P">PW Goaz</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wood, Nk" uniqKey="Wood N">NK Wood</name></author><author><name sortKey="Goaz, Pw" uniqKey="Goaz P">PW Goaz</name></author><author><name sortKey="Sawyer, Dr" uniqKey="Sawyer D">DR Sawyer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Priddy, Rw" uniqKey="Priddy R">RW Priddy</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Amler, Mh" uniqKey="Amler M">MH Amler</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nedir, R" uniqKey="Nedir R">R Nedir</name></author><author><name sortKey="Lombardi, T" uniqKey="Lombardi T">T Lombardi</name></author><author><name sortKey="Samson, J" uniqKey="Samson J">J Samson</name></author></analytic></biblStruct></listBibl></div1></back></TEI><pmc article-type="case-report"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Contemp Clin Dent</journal-id><journal-id journal-id-type="iso-abbrev">Contemp Clin Dent</journal-id><journal-id journal-id-type="publisher-id">CCD</journal-id><journal-title-group><journal-title>Contemporary Clinical Dentistry</journal-title></journal-title-group><issn pub-type="ppub">0976-237X</issn><issn pub-type="epub">0976-2361</issn><publisher><publisher-name>Medknow Publications & Media Pvt Ltd</publisher-name><publisher-loc>India</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">22557907</article-id><article-id pub-id-type="pmc">3341770</article-id><article-id pub-id-type="publisher-id">CCD-3-93</article-id><article-id pub-id-type="doi">10.4103/0976-237X.94556</article-id><article-categories><subj-group subj-group-type="heading"><subject>Case Report</subject></subj-group></article-categories><title-group><article-title>Management of an unusual peripheral giant cell granuloma: A diagnostic dilemma</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Mannem</surname><given-names>Satheesh</given-names></name><xref ref-type="aff" rid="aff1"></xref><xref ref-type="corresp" rid="cor1"></xref></contrib><contrib contrib-type="author"><name><surname>Chava</surname><given-names>Vijay K.</given-names></name><xref ref-type="aff" rid="aff2">1</xref></contrib></contrib-group><aff id="aff1"><italic>Department of Periodontics, Vishnu Dental College and Hospital, Bhimavaram, Andhra Pradesh, India</italic></aff><aff id="aff2"><label>1</label><italic>Department of Periodontics, Narayana Dental College and Hospital, Nellore, Andhra Pradesh, India</italic></aff><author-notes><corresp id="cor1"><bold>Correspondence:</bold> Dr. Satheesh Mannem, Parlapalli (Post), Vidavalur (Mandal), Nellore, Andhra Pradesh -524 318, India. E-mail: <email xlink:href="satheeshmannem@gmail.com">satheeshmannem@gmail.com</email></corresp></author-notes><pub-date pub-type="ppub"><season>Jan-Mar</season><year>2012</year></pub-date><volume>3</volume><issue>1</issue><fpage>93</fpage><lpage>96</lpage><permissions><copyright-statement>Copyright: © Contemporary Clinical Dentistry</copyright-statement><copyright-year>2012</copyright-year><license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by-nc-sa/3.0"><license-p>This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</license-p></license></permissions><abstract><p>The peripheral giant cell granuloma (PGCG) is a reactive exophytic lesion of the gingiva and alveolar ridge that usually occurs as a result of local irritating factors such as plaque, calculus, chronic infections, chronic irritation, tooth extraction, improperly finished fillings, unstable dental prosthesis, and impacted food which originates from the periosteum or periodontal ligament. This article presents management of an unusual PGCG located on the partially edentulous mandible.</p></abstract><kwd-group><kwd>Chronic irritation</kwd><kwd>excision</kwd><kwd>exophytic growth</kwd><kwd>food impaction</kwd><kwd>peripheral giant cell granuloma</kwd></kwd-group></article-meta></front><body><sec id="sec1-1"><title>Introduction</title><p>The peripheral giant cell granuloma (PGCG), also known as a giant-cell epulis, giant-cell reparative granuloma, osteoclastoma, or giant-cell hyperplasia, is a reactive exophytic lesion of gingiva and alveolar ridge which originates from the periosteum or periodontal ligament.[<xref ref-type="bibr" rid="ref1">1</xref><xref ref-type="bibr" rid="ref2">2</xref>] The lesion can develop at any age, though it is more common between the fifth and sixth decades of life, and shows a slight female predilection.[<xref ref-type="bibr" rid="ref3">3</xref><xref ref-type="bibr" rid="ref4">4</xref>] Even though there is no clear evident etiology, it is thought that it may be due to plaque, calculus, constant trauma, tooth extraction, overhanging restorations, unstable dental prosthesis, chronic infections, and food impaction.[<xref ref-type="bibr" rid="ref5">5</xref>–<xref ref-type="bibr" rid="ref8">8</xref>] Clinical appearance of PGCGs can present as polyploidy or nodular lesions, primarily bluish red with a smooth shiny or mamillated surface, stalky or sessile base, small and well demarcated.[<xref ref-type="bibr" rid="ref9">9</xref><xref ref-type="bibr" rid="ref10">10</xref>] Histological features of PGCG reveal a non-capsulated mass of tissue containing a large number of young connective tissue cells and multinucleated giant cells. Hemorrhage, hemosiderin, inflammatory cells, and newly formed bone or calcified material may also be seen throughout the cellular connective tissue.[<xref ref-type="bibr" rid="ref1">1</xref><xref ref-type="bibr" rid="ref11">11</xref>] PGCG is a soft tissue lesion that infrequently affects the underlying bone, although the latter may undergo superficial erosion.[<xref ref-type="bibr" rid="ref8">8</xref><xref ref-type="bibr" rid="ref12">12</xref>] The PGCG may cause underlying bone resorption and less commonly underlying teeth. These lesions are not painful unless they are traumatized.</p></sec><sec id="sec1-2"><title>Case Report</title><p>A 65-year-old man was referred to Narayana Dental College & Hospital, Nellore, had an intraoral swelling on partially edentulous mandibular alveolar ridge extending from mesial aspect of right mandibular canine region to distal aspect of left mandibular second premolar region, measuring 6 × 5 × 5 cm [Figures <xref ref-type="fig" rid="F1">1</xref> and <xref ref-type="fig" rid="F2">2</xref>]. The patient had noticed the lesion 2 years back and it gradually increased in size. The lesion was well-defined, sessile, hyperplastic, exophytic growth, and normal in color with bluish red tinge on the entire surface of the lesion. On palpation, the lesion was non-tender, soft in consistency extending to the floor of the mouth lingually and into the buccal vestibule buccally. Orthopantomograph [<xref ref-type="fig" rid="F3">Figure 3</xref>] and occlusal view [<xref ref-type="fig" rid="F4">Figure 4</xref>] revealed that there is no bony involvement of the lesion and family history of the patient was non-contributory. Extraoral findings were absent. After thorough clinical and radiological examination, it was decided to perform incisional biopsy due to the extensive size of the lesion and expected wound management complication. During biopsy, it was noted that the lesion bled profusely, which was controlled by physical pressure. The specimen was sent for histopathological examination after the incisional biopsy.</p><fig id="F1" position="float"><label>Figure 1</label><caption><p>Intraoral swelling – facial view</p></caption><graphic xlink:href="CCD-3-93-g001"></graphic></fig><fig id="F2" position="float"><label>Figure 2</label><caption><p>Intraoral swelling – occlusal view</p></caption><graphic xlink:href="CCD-3-93-g002"></graphic></fig><fig id="F3" position="float"><label>Figure 3</label><caption><p>OPG showing no evidence of bone involvement</p></caption><graphic xlink:href="CCD-3-93-g003"></graphic></fig><fig id="F4" position="float"><label>Figure 4</label><caption><p>Occlusal radiograph showing no evidence of bone involvement</p></caption><graphic xlink:href="CCD-3-93-g004"></graphic></fig><p>As the lesion was exophytic and hyperplastic in nature, differential diagnosis includes central giant cell granuloma and fibroma.[<xref ref-type="bibr" rid="ref10">10</xref><xref ref-type="bibr" rid="ref13">13</xref>] Due to extravasated deoxygenated erythrocytes at the periphery and various amounts of hemosiderin pigment, the mucosa appeared bluish red to pale pink. So, the differential diagnosis also includes hemangioma, lymphangioma, metastatic tumors of gingiva, nevi, other nodular melanomas, PGCG, and other inflammatory hyperplastic lesions.[<xref ref-type="bibr" rid="ref14">14</xref>] Even though the lesion was exophytic in nature, absence of ossification did not support the central giant cell granuloma and presence of vascularity did not support the fibroma. Most hemangiomas are present since birth, whereas the present lesion was of relatively recent onset. Absence of a history of primary tumor elsewhere and absence of uneven bone destruction under the exophytic lesion ruled out the chance of possible metastasis to gingiva. Oral nevi and nodular melanomas occur less frequently and almost all cases are firmer on the palpation. Except for the amelanotic varieties, they are usually dark. Finally, a nodular melanoma has a history of rapid growth. In contrast, the present lesion was bluish red to pale pink in color and slowly progressing in nature. Soft to firm consistency, bluish red color, slow-growing nature, recent in onset, location on the gingiva and residual alveolar ridge, presence of vascularity, hyperplastic and exophytic growth clinically supports inflammatory hyperplastic lesions. But the presence of excess number of disseminated giant cells in connective tissue stroma along with hemorrhage, hemosiderin pigment, and inflammatory cells [Figures <xref ref-type="fig" rid="F5">5</xref> and <xref ref-type="fig" rid="F6">6</xref>] in histological examination excludes other inflammatory hyperplastic lesions and confirms PGCG.[<xref ref-type="bibr" rid="ref13">13</xref><xref ref-type="bibr" rid="ref15">15</xref>]</p><fig id="F5" position="float"><label>Figure 5</label><caption><p>Histopathological view of lesion (hematoxylin and eosin X40)</p></caption><graphic xlink:href="CCD-3-93-g005"></graphic></fig><fig id="F6" position="float"><label>Figure 6</label><caption><p>Histopathological view of lesion (hematoxylin and eosin X200)</p></caption><graphic xlink:href="CCD-3-93-g006"></graphic></fig><p>After arriving to diagnosis as PGCG, the lesion was excised [<xref ref-type="fig" rid="F7">Figure 7</xref>] and four interrupted sutures were placed [<xref ref-type="fig" rid="F8">Figure 8</xref>] to close the defect. While performing excision procedure, the lesion bled profusely. There were four prominent blood vessels that were originated from the base of the above mentioned swelling and were bleeding incessantly. The lesion was cauterized to achieve hemostasis since they are very close to bone and inaccessible to ligate.</p><fig id="F7" position="float"><label>Figure 7</label><caption><p>Excised specimen</p></caption><graphic xlink:href="CCD-3-93-g007"></graphic></fig><fig id="F8" position="float"><label>Figure 8</label><caption><p>Intraoral view after excision with sutures</p></caption><graphic xlink:href="CCD-3-93-g008"></graphic></fig></sec><sec sec-type="discussion" id="sec1-3"><title>Discussion</title><p>PGCG is uncommon benign hyperplastic lesion of the oral mucosa which originates from the gingiva or mucoperiosteum of alveolar bone and is caused by local irritation and chronic trauma. PGCG is more common in mandible than in the maxilla and common in anterior region than posterior region. Clinically, PGCG is smooth, nodular brown, red or bluish nodule which is sessile or pedunculated.[<xref ref-type="bibr" rid="ref1">1</xref><xref ref-type="bibr" rid="ref2">2</xref>] Generally, PGCG size varies from 0.5 to 1.5 cm in diameter. Very few cases of 5 cm diameter PGCG were also reported in literature in which poor oral hygiene and food impaction are the major etiological factors in the lesion growth.[<xref ref-type="bibr" rid="ref7">7</xref><xref ref-type="bibr" rid="ref8">8</xref>] As of our knowledge, this is the first case report in which the lesion size (6 × 5 × 5 cm) exceeded 5 cm in diameter and confusing. Histopathologic characteristics of PGCG may be consistent with periodontal ligament or periosteum origin.[<xref ref-type="bibr" rid="ref1">1</xref><xref ref-type="bibr" rid="ref2">2</xref>] Histologically, PGCG is identified as a non-capsulated mass of tissue consisting of reticular and fibrillar connective tissue containing young connective tissue cells of ovoid or fusiform shape and multinuclear giant cells. The distinctive feature of PGCG is distinctive mainly due to excess number of giant cells that are disseminated in the connective tissue stroma.[<xref ref-type="bibr" rid="ref8">8</xref><xref ref-type="bibr" rid="ref10">10</xref>] The exact basis of giant cells is uncertain. Many opinions have been identified in the literature as osteoblasts, phagocytes, endothelial cells, and spindle cells are thought to be responsible for giant cell proliferation.[<xref ref-type="bibr" rid="ref3">3</xref>] In our present case report, it could be because of chronic irritation and food impaction. Abnormal occlusal forces due to many missing teeth might have created tissue irritation on the areas of residual alveolar ridge. This might be an irritant factor for PGCG development. This could be further substantiated by food impaction. Dental resorption is extremely rare. Only two cases have been reported in literature.[<xref ref-type="bibr" rid="ref16">16</xref>] In our case report, dental resorption is not observed since it is located on the edentulous ridge. The radiographic examination generally has no findings since it is confined to soft tissue without involving the bone. Because of the recurrence rate, approximately 10 to 15%, close follow-up is indicated.[<xref ref-type="bibr" rid="ref3">3</xref>] Patient was reevaluated after 2 years [<xref ref-type="fig" rid="F9">Figure 9</xref>] and 4 years [<xref ref-type="fig" rid="F10">Figure 10</xref>] which is in line with recommendation discussed by and Nedir R <italic>et al</italic>.,[<xref ref-type="bibr" rid="ref17">17</xref>] and there were no complaints or recurrence.</p><fig id="F9" position="float"><label>Figure 9</label><caption><p>Intraoral view during 2-year follow-up visit</p></caption><graphic xlink:href="CCD-3-93-g009"></graphic></fig><fig id="F10" position="float"><label>Figure 10</label><caption><p>Intraoral view during 4-year follow-up visit</p></caption><graphic xlink:href="CCD-3-93-g010"></graphic></fig></sec></body><back><fn-group><fn fn-type="supported-by"><p><bold>Source of Support:</bold> Nil.</p></fn><fn fn-type="conflict"><p><bold>Conflict of Interest:</bold> None declared.</p></fn></fn-group><ref-list><ref id="ref1"><label>1</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Katsikeris</surname><given-names>N</given-names></name><name><surname>Kakarantza-Angelopoulou</surname><given-names>E</given-names></name><name><surname>Angelopoulos</surname><given-names>AP</given-names></name></person-group><article-title>Peripheral giant cell granuloma: Clinicopathologic study of 224 new cases and review of 956 reported cases</article-title><source>Int J Oral Maxillofac Surg</source><year>1988</year><volume>17</volume><fpage>94</fpage><lpage>9</lpage><pub-id pub-id-type="pmid">3133432</pub-id></element-citation></ref><ref id="ref2"><label>2</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Bodner</surname><given-names>L</given-names></name><name><surname>Peist</surname><given-names>M</given-names></name><name><surname>Gatot</surname><given-names>A</given-names></name><name><surname>Fliss</surname><given-names>DM</given-names></name></person-group><article-title>Growth potential of peripheral giant cell granuloma</article-title><source>Oral Surg Oral Med Oral Pathol Oral Radiol Endod</source><year>1997</year><volume>83</volume><fpage>548</fpage><lpage>51</lpage><pub-id pub-id-type="pmid">9159813</pub-id></element-citation></ref><ref id="ref3"><label>3</label><element-citation publication-type="book"><person-group person-group-type="author"><name><surname>Shafer</surname><given-names>WG</given-names></name><name><surname>Hine</surname><given-names>MK</given-names></name><name><surname>Levy</surname><given-names>BM</given-names></name></person-group><source>A textbook of oral pathol</source><year>2009</year><edition>6th ed</edition><publisher-loc>Philadelphia</publisher-loc><publisher-name>WB Saunders</publisher-name><fpage>130</fpage><lpage>2</lpage></element-citation></ref><ref id="ref4"><label>4</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Motamedi</surname><given-names>MH</given-names></name><name><surname>Eshghyar</surname><given-names>N</given-names></name><name><surname>Jafari</surname><given-names>SM</given-names></name><name><surname>Lassemi</surname><given-names>E</given-names></name><name><surname>Navi</surname><given-names>F</given-names></name><name><surname>Abbas</surname><given-names>FM</given-names></name><etal></etal></person-group><article-title>Peripheral and cen-tral giant cell granulomas of the jaws: A demographic study</article-title><source>Oral Surg Oral Med Oral Pathol Oral Radiol Endod</source><year>2007</year><volume>103</volume><fpage>e39</fpage><lpage>43</lpage><pub-id pub-id-type="pmid">17428697</pub-id></element-citation></ref><ref id="ref5"><label>5</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Anneroth</surname><given-names>G</given-names></name><name><surname>Sigurdson</surname><given-names>A</given-names></name></person-group><article-title>Hyperplastic lesions of the gingi-va and alveolar mucosa. 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