Cryosurgery as an Option for the Treatment of Vascular Lesions of the Oral Cavity
Identifieur interne : 001B69 ( Pmc/Corpus ); précédent : 001B68; suivant : 001B70Cryosurgery as an Option for the Treatment of Vascular Lesions of the Oral Cavity
Auteurs : Pedro Thalles Bernardo De Carvalho Nogueira ; Mariana Maria Castro Jatobá Remigio ; Andreza Maria Correia De Queiroz ; Andréia Aparecida Da Silva ; José Rodrigues Laureano FilhoSource :
- Case Reports in Otolaryngology [ 2090-6765 ] ; 2017.
Abstract
Cryosurgery is a treatment modality consisting in the destruction of tissue by the application of extremely low temperatures. This causes irreversible damage to cellular metabolism, leading to tissue destruction within minutes, a mechanism that may be beneficial when used in diseased tissues. Because cryosurgery is effective, simple, and easy to perform, it has been used in the treatment of lesions in both medical and dental fields. This technique provides many advantages, such as easy operation, absence of intraoperative bleeding, and low infection rate. We report the case of a patient with a hemangiomatous lesion of the oral cavity who was treated with liquid nitrogen spray cryosurgery, with successful results at 18-month follow-up.
Url:
DOI: 10.1155/2017/8529016
PubMed: 28831321
PubMed Central: 5558673
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Cryosurgery as an Option for the Treatment of Vascular Lesions of the Oral Cavity</title><author><name sortKey="Nogueira, Pedro Thalles Bernardo De Carvalho" sort="Nogueira, Pedro Thalles Bernardo De Carvalho" uniqKey="Nogueira P" first="Pedro Thalles Bernardo De Carvalho" last="Nogueira">Pedro Thalles Bernardo De Carvalho Nogueira</name><affiliation><nlm:aff id="I1">Universidade Tiradentes (UNIT), Maceió, AL, Brazil</nlm:aff></affiliation><affiliation><nlm:aff id="I2">Oral and Maxillofacial Surgery, Hospital Universitário Oswaldo Cruz (HUOC), School of Dentistry, Universidade de Pernambuco (UPE), Recife, PE, Brazil</nlm:aff></affiliation><affiliation><nlm:aff id="I3">Oral and Maxillofacial Surgery, Universidade do Sagrado Coração (USC), Bauru, SP, Brazil</nlm:aff></affiliation></author><author><name sortKey="Remigio, Mariana Maria Castro Jatoba" sort="Remigio, Mariana Maria Castro Jatoba" uniqKey="Remigio M" first="Mariana Maria Castro Jatobá" last="Remigio">Mariana Maria Castro Jatobá Remigio</name><affiliation><nlm:aff id="I4">Dentistry, UNIT, Maceió, AL, Brazil</nlm:aff></affiliation></author><author><name sortKey="De Queiroz, Andreza Maria Correia" sort="De Queiroz, Andreza Maria Correia" uniqKey="De Queiroz A" first="Andreza Maria Correia" last="De Queiroz">Andreza Maria Correia De Queiroz</name><affiliation><nlm:aff id="I4">Dentistry, UNIT, Maceió, AL, Brazil</nlm:aff></affiliation></author><author><name sortKey="Da Silva, Andreia Aparecida" sort="Da Silva, Andreia Aparecida" uniqKey="Da Silva A" first="Andréia Aparecida" last="Da Silva">Andréia Aparecida Da Silva</name><affiliation><nlm:aff id="I5">Doctoral Program in Oral and Maxillofacial Surgery, USC, Bauru, SP, Brazil</nlm:aff></affiliation></author><author><name sortKey="Filho, Jose Rodrigues Laureano" sort="Filho, Jose Rodrigues Laureano" uniqKey="Filho J" first="José Rodrigues Laureano" last="Filho">José Rodrigues Laureano Filho</name><affiliation><nlm:aff id="I6">Oral and Maxillofacial Surgery, Pernambuco School of Dentistry (FOP), Universidade de Pernambuco (UPE), Camaragibe, PE, Brazil</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">28831321</idno><idno type="pmc">5558673</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5558673</idno><idno type="RBID">PMC:5558673</idno><idno type="doi">10.1155/2017/8529016</idno><date when="2017">2017</date><idno type="wicri:Area/Pmc/Corpus">001B69</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001B69</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Cryosurgery as an Option for the Treatment of Vascular Lesions of the Oral Cavity</title><author><name sortKey="Nogueira, Pedro Thalles Bernardo De Carvalho" sort="Nogueira, Pedro Thalles Bernardo De Carvalho" uniqKey="Nogueira P" first="Pedro Thalles Bernardo De Carvalho" last="Nogueira">Pedro Thalles Bernardo De Carvalho Nogueira</name><affiliation><nlm:aff id="I1">Universidade Tiradentes (UNIT), Maceió, AL, Brazil</nlm:aff></affiliation><affiliation><nlm:aff id="I2">Oral and Maxillofacial Surgery, Hospital Universitário Oswaldo Cruz (HUOC), School of Dentistry, Universidade de Pernambuco (UPE), Recife, PE, Brazil</nlm:aff></affiliation><affiliation><nlm:aff id="I3">Oral and Maxillofacial Surgery, Universidade do Sagrado Coração (USC), Bauru, SP, Brazil</nlm:aff></affiliation></author><author><name sortKey="Remigio, Mariana Maria Castro Jatoba" sort="Remigio, Mariana Maria Castro Jatoba" uniqKey="Remigio M" first="Mariana Maria Castro Jatobá" last="Remigio">Mariana Maria Castro Jatobá Remigio</name><affiliation><nlm:aff id="I4">Dentistry, UNIT, Maceió, AL, Brazil</nlm:aff></affiliation></author><author><name sortKey="De Queiroz, Andreza Maria Correia" sort="De Queiroz, Andreza Maria Correia" uniqKey="De Queiroz A" first="Andreza Maria Correia" last="De Queiroz">Andreza Maria Correia De Queiroz</name><affiliation><nlm:aff id="I4">Dentistry, UNIT, Maceió, AL, Brazil</nlm:aff></affiliation></author><author><name sortKey="Da Silva, Andreia Aparecida" sort="Da Silva, Andreia Aparecida" uniqKey="Da Silva A" first="Andréia Aparecida" last="Da Silva">Andréia Aparecida Da Silva</name><affiliation><nlm:aff id="I5">Doctoral Program in Oral and Maxillofacial Surgery, USC, Bauru, SP, Brazil</nlm:aff></affiliation></author><author><name sortKey="Filho, Jose Rodrigues Laureano" sort="Filho, Jose Rodrigues Laureano" uniqKey="Filho J" first="José Rodrigues Laureano" last="Filho">José Rodrigues Laureano Filho</name><affiliation><nlm:aff id="I6">Oral and Maxillofacial Surgery, Pernambuco School of Dentistry (FOP), Universidade de Pernambuco (UPE), Camaragibe, PE, Brazil</nlm:aff></affiliation></author></analytic><series><title level="j">Case Reports in Otolaryngology</title><idno type="ISSN">2090-6765</idno><idno type="eISSN">2090-6773</idno><imprint><date when="2017">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Cryosurgery is a treatment modality consisting in the destruction of tissue by the application of extremely low temperatures. This causes irreversible damage to cellular metabolism, leading to tissue destruction within minutes, a mechanism that may be beneficial when used in diseased tissues. Because cryosurgery is effective, simple, and easy to perform, it has been used in the treatment of lesions in both medical and dental fields. This technique provides many advantages, such as easy operation, absence of intraoperative bleeding, and low infection rate. We report the case of a patient with a hemangiomatous lesion of the oral cavity who was treated with liquid nitrogen spray cryosurgery, with successful results at 18-month follow-up.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Chen, T H" uniqKey="Chen T">T. H. Chen</name></author><author><name sortKey="Huang, C J" uniqKey="Huang C">C. J. Huang</name></author><author><name sortKey="Huang, Y Y" uniqKey="Huang Y">Y. Y. Huang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yeh, C J" uniqKey="Yeh C">C.-J. Yeh</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Benaglia, M B" uniqKey="Benaglia M">M. B. Benaglia</name></author><author><name sortKey="Jardim, E C G" uniqKey="Jardim E">E. C. G. Jardim</name></author><author><name sortKey="Mendonca, J C G" uniqKey="Mendonca J">J. C. G. Mendonça</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rubinsky, B" uniqKey="Rubinsky B">B. Rubinsky</name></author><author><name sortKey="Onik, G" uniqKey="Onik G">G. Onik</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Graham, G F" uniqKey="Graham G">G. F. Graham</name></author><author><name sortKey="Barham, K L" uniqKey="Barham K">K. L. Barham</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gage, A A" uniqKey="Gage A">A. A. Gage</name></author><author><name sortKey="Baust, J" uniqKey="Baust J">J. Baust</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Prasad, M" uniqKey="Prasad M">M. Prasad</name></author><author><name sortKey="Kale, T P" uniqKey="Kale T">T. P. Kale</name></author><author><name sortKey="Halli, R" uniqKey="Halli R">R. Halli</name></author><author><name sortKey="Kotrashetti, S M" uniqKey="Kotrashetti S">S. M. Kotrashetti</name></author><author><name sortKey="Baliga, S D" uniqKey="Baliga S">S. D. Baliga</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Toida, M" uniqKey="Toida M">M. Toida</name></author><author><name sortKey="Ishimaru, J I" uniqKey="Ishimaru J">J.-I. Ishimaru</name></author><author><name sortKey="Hobo, N" uniqKey="Hobo N">N. Hobo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zakrzewska, J M" uniqKey="Zakrzewska J">J. M. Zakrzewska</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fernandez Vozmediano, J" uniqKey="Fernandez Vozmediano J">J. Fernández-Vozmediano</name></author><author><name sortKey="Armario Hita, J C" uniqKey="Armario Hita J">J. C. Armario-Hita</name></author><author><name sortKey="Nieto Herce, A" uniqKey="Nieto Herce A">A. Nieto-Herce</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Carnasciali, M C G" uniqKey="Carnasciali M">M. C. G. Carnasciali</name></author><author><name sortKey="Marinho, S A" uniqKey="Marinho S">S. A. Marinho</name></author><author><name sortKey="Pototski, M" uniqKey="Pototski M">M. Pototski</name></author><author><name sortKey="Amenabar, J M" uniqKey="Amenabar J">J. M. Amenábar</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hausamen, J E" uniqKey="Hausamen J">J.-E. Hausamen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hartmann, P K" uniqKey="Hartmann P">P. K. Hartmann</name></author><author><name sortKey="Verne, D" uniqKey="Verne D">D. Verne</name></author><author><name sortKey="Davis, R G" uniqKey="Davis R">R. G. Davis</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tal, H" uniqKey="Tal H">H. Tal</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bekke, J P H" uniqKey="Bekke J">J. P. H. Bekke</name></author><author><name sortKey="Baart, J A" uniqKey="Baart J">J. A. Baart</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gallardo, J L H" uniqKey="Gallardo J">J. L. H. Gallardo</name></author><author><name sortKey="G Mez, F M" uniqKey="G Mez F">F. M. Gómez</name></author><author><name sortKey="Le N, M G" uniqKey="Le N M">M. G. León</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Li, Z" uniqKey="Li Z">Z. Li</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sako, K" uniqKey="Sako K">K. Sako</name></author><author><name sortKey="Marchetta, F C" uniqKey="Marchetta F">F. C. Marchetta</name></author><author><name sortKey="Hayes, R L" uniqKey="Hayes R">R. L. Hayes</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Leopard, P J" uniqKey="Leopard P">P. J. Leopard</name></author></analytic></biblStruct></listBibl></div1></back></TEI><pmc article-type="case-report"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Case Rep Otolaryngol</journal-id><journal-id journal-id-type="iso-abbrev">Case Rep Otolaryngol</journal-id><journal-id journal-id-type="publisher-id">CRIOT</journal-id><journal-title-group><journal-title>Case Reports in Otolaryngology</journal-title></journal-title-group><issn pub-type="ppub">2090-6765</issn><issn pub-type="epub">2090-6773</issn><publisher><publisher-name>Hindawi</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">28831321</article-id><article-id pub-id-type="pmc">5558673</article-id><article-id pub-id-type="doi">10.1155/2017/8529016</article-id><article-categories><subj-group subj-group-type="heading"><subject>Case Report</subject></subj-group></article-categories><title-group><article-title>Cryosurgery as an Option for the Treatment of Vascular Lesions of the Oral Cavity</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Nogueira</surname><given-names>Pedro Thalles Bernardo de Carvalho</given-names></name><xref ref-type="aff" rid="I1"><sup>1</sup></xref><xref ref-type="aff" rid="I2"><sup>2</sup></xref><xref ref-type="aff" rid="I3"><sup>3</sup></xref></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid" authenticated="false">http://orcid.org/0000-0002-2338-8023</contrib-id><name><surname>Remigio</surname><given-names>Mariana Maria Castro Jatobá</given-names></name><xref ref-type="aff" rid="I4"><sup>4</sup></xref><xref ref-type="corresp" rid="cor1"><sup>*</sup></xref></contrib><contrib contrib-type="author"><name><surname>de Queiroz</surname><given-names>Andreza Maria Correia</given-names></name><xref ref-type="aff" rid="I4"><sup>4</sup></xref></contrib><contrib contrib-type="author"><name><surname>da Silva</surname><given-names>Andréia Aparecida</given-names></name><xref ref-type="aff" rid="I5"><sup>5</sup></xref></contrib><contrib contrib-type="author"><name><surname>Filho</surname><given-names>José Rodrigues Laureano</given-names></name><xref ref-type="aff" rid="I6"><sup>6</sup></xref></contrib></contrib-group><aff id="I1"><sup>1</sup>Universidade Tiradentes (UNIT), Maceió, AL, Brazil</aff><aff id="I2"><sup>2</sup>Oral and Maxillofacial Surgery, Hospital Universitário Oswaldo Cruz (HUOC), School of Dentistry, Universidade de Pernambuco (UPE), Recife, PE, Brazil</aff><aff id="I3"><sup>3</sup>Oral and Maxillofacial Surgery, Universidade do Sagrado Coração (USC), Bauru, SP, Brazil</aff><aff id="I4"><sup>4</sup>Dentistry, UNIT, Maceió, AL, Brazil</aff><aff id="I5"><sup>5</sup>Doctoral Program in Oral and Maxillofacial Surgery, USC, Bauru, SP, Brazil</aff><aff id="I6"><sup>6</sup>Oral and Maxillofacial Surgery, Pernambuco School of Dentistry (FOP), Universidade de Pernambuco (UPE), Camaragibe, PE, Brazil</aff><author-notes><corresp id="cor1">*Mariana Maria Castro Jatobá Remigio: <email>marianajremigio@hotmail.com</email></corresp><fn fn-type="other"><p>Academic Editor: Abrão Rapoport</p></fn></author-notes><pub-date pub-type="ppub"><year>2017</year></pub-date><pub-date pub-type="epub"><day>2</day><month>8</month><year>2017</year></pub-date><volume>2017</volume><elocation-id>8529016</elocation-id><history><date date-type="received"><day>20</day><month>6</month><year>2017</year></date><date date-type="accepted"><day>5</day><month>7</month><year>2017</year></date></history><permissions><copyright-statement>Copyright © 2017 Pedro Thalles Bernardo de Carvalho Nogueira et al.</copyright-statement><copyright-year>2017</copyright-year><license xlink:href="https://creativecommons.org/licenses/by/4.0/"><license-p>This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</license-p></license></permissions><abstract><p>Cryosurgery is a treatment modality consisting in the destruction of tissue by the application of extremely low temperatures. This causes irreversible damage to cellular metabolism, leading to tissue destruction within minutes, a mechanism that may be beneficial when used in diseased tissues. Because cryosurgery is effective, simple, and easy to perform, it has been used in the treatment of lesions in both medical and dental fields. This technique provides many advantages, such as easy operation, absence of intraoperative bleeding, and low infection rate. We report the case of a patient with a hemangiomatous lesion of the oral cavity who was treated with liquid nitrogen spray cryosurgery, with successful results at 18-month follow-up.</p></abstract></article-meta></front><body><sec id="sec1"><title>1. Introduction</title><p>Cryotherapy or cryosurgery is a form of therapy consisting in the in situ destruction of tissue by the application of extremely low temperatures [<xref rid="B1" ref-type="bibr">1</xref>, <xref rid="B2" ref-type="bibr">2</xref>]. The resulting cryogenic lesion is characterized by sharply circumscribed necrosis that corresponds to the volume of previously frozen tissue, and this term is used to refer to the effect of tissue freezing [<xref rid="B3" ref-type="bibr">3</xref>].</p><p>Although reports of the use of ice for therapeutic purposes date back to about 3000 BC [<xref rid="B4" ref-type="bibr">4</xref>, <xref rid="B5" ref-type="bibr">5</xref>], it was only in the mid-1960s that the basic features of cryosurgical technique, that is, rapid freezing, slow thawing, and repetition of the freeze-thaw cycle, were established [<xref rid="B6" ref-type="bibr">6</xref>]. Since then, this treatment modality has been successfully applied across a wide range of medical fields, such as dermatology, proctology, gynecology, neurosurgery, ophthalmology, general surgery, and head and neck surgery [<xref rid="B4" ref-type="bibr">4</xref>, <xref rid="B7" ref-type="bibr">7</xref>].</p><p>In oral and maxillofacial surgery, cryotherapy is the gold standard for the treatment of various types of lesions occurring in the oral cavity. It can be used as a single treatment for mucocele [<xref rid="B8" ref-type="bibr">8</xref>], trigeminal neuralgia [<xref rid="B9" ref-type="bibr">9</xref>], leukoplakia, hemangioma, pyogenic granuloma, HPV lesions, actinic cheilitis, lichen planus, and fibromas [<xref rid="B2" ref-type="bibr">2</xref>, <xref rid="B10" ref-type="bibr">10</xref>, <xref rid="B11" ref-type="bibr">11</xref>] and as a complementary treatment in cases of bone lesions with high recurrence rates, such as ameloblastomas, myxomas, keratocystic odontogenic tumor, ossifying fibroma, and central giant cell lesions. The standard treatment for these lesions is usually aggressive and involves resection with safety margins, which often results in major cosmetic and functional defects for the patient. In this respect, cryosurgery provides the most effective alternative to ensure the safety margin without causing major defects, since it destroys deep diseased tissue through in situ freezing [<xref rid="B11" ref-type="bibr">11</xref>].</p><p>Given the wide applicability of cryosurgery in the field of oral and maxillofacial surgery, we report a case of hemangioma of the oral cavity successfully treated with cryosurgery.</p></sec><sec id="sec2"><title>2. Case Report</title><p>A 65-year-old white woman presented to the Department of Oral and Maxillofacial Surgery at the Pernambuco School of Dentistry, Universidade de Pernambuco, Northeastern Brazil, complaining of a purplish lesion on the left lateral border of the tongue. The patient reported that the onset of the lesion had occurred about 2 years earlier and that it continued to grow slowly and asymptomatically. The patient had diabetes and hypertension. She had no family history of malignancies and no history of smoking or alcohol consumption.</p><p>Extraoral physical examination revealed no changes in the patient's facial anatomy. Cervical lymph node characteristics were within the normal range. Intraoral examination revealed that the patient was completely edentulous in the maxilla and partially edentulous in the mandible. An asymptomatic, purplish, sessile nodular lesion, firm to palpation, and measuring about 1.5 cm in its greatest diameter was found on the left lateral border of the tongue (<xref ref-type="fig" rid="fig1">Figure 1</xref>). Diascopy, performed by applying pressure on the lesion with a glass slide, showed that the lesion had an ischemic pattern. Fine-needle aspiration was performed and the result was positive for bloody content, suggestive of a hemangiomatous lesion (<xref ref-type="fig" rid="fig2">Figure 2</xref>).</p><p>Based on clinical findings, the diagnosis of hemangioma was made. It is worth noting that, in cases of hemangiomatous lesions, incisional biopsy is totally contraindicated, because even partial manipulation of the lesion may cause significant bleeding.</p><p>Several treatment modalities reported in the literature for this condition were reviewed and, for this case, cryosurgery with liquid nitrogen was chosen as definitive treatment (<xref ref-type="fig" rid="fig3">Figure 3</xref>).</p><p>The patient was hemodynamically stable and cryosurgery was performed under local anesthesia in an outpatient setting. The surgical site was disinfected with 2% chlorhexidine digluconate gel, followed by anesthesia of the tongue apex and of the affected area by anesthetic block of the lesion site with lidocaine with epinephrine (1 : 100,000). The tongue apex was sutured with 3-0 nylon, the tongue was pulled to the right, and adjacent tissues (tongue, cheek mucosa, palate, and teeth) were protected by gauze with Vaseline (<xref ref-type="fig" rid="fig4">Figure 4</xref>).</p><p>Liquid nitrogen spray cryosurgery was performed in a single session of two cycles of 1 minute each, with a 2-minute interval between cycles (<xref ref-type="fig" rid="fig5">Figure 5</xref>). Immediately after the procedure, the lesion was whitish in color, characterizing the freezing process, and, a few minutes later, after thawing, edema and erythema formations were observed in the treated area (<xref ref-type="fig" rid="fig6">Figure 6</xref>).</p><p>The patient returned for outpatient follow-up at 1, 3, 6, and 8 weeks postoperatively (Figures <xref ref-type="fig" rid="fig7">7</xref>, <xref ref-type="fig" rid="fig8">8</xref>, <xref ref-type="fig" rid="fig9">9</xref>, and <xref ref-type="fig" rid="fig10">10</xref>). On the first postoperative days, the patient complained of mild pain, which was managed with dipyrone (500 mg) every 6 hours for 5 days. There were no signs of infection during the healing period.</p><p>At the time of the last follow-up, 18 months after treatment, the patient was clinically well, without sensory changes in the tongue, abnormal speech, or impaired swallowing and with no signs of recurrence of the lesion. A slight scar retraction was observed at the lesion site (<xref ref-type="fig" rid="fig11">Figure 11</xref>).</p></sec><sec id="sec3"><title>3. Discussion</title><p>Cryosurgery consists in freezing the tissues in order to obtain local destructive effects and subsequent therapeutic action [<xref rid="B1" ref-type="bibr">1</xref>]. Over time, several authors have reported on the successful use of this modality in the treatment of various types of lesions. Yeh [<xref rid="B2" ref-type="bibr">2</xref>] and Rubinsky and Onik [<xref rid="B4" ref-type="bibr">4</xref>] described the use of cryosurgery in several areas, such as dermatology, oncology, hepatology, proctology, urology, ophthalmology, general surgery, and oral and maxillofacial surgery.</p><p>Hausamen [<xref rid="B12" ref-type="bibr">12</xref>], for 3 years, successfully treated several diseases of the oral cavity, including hemangioma, leukoplakia, and squamous cell carcinoma. In agreement with the results obtained and reported in the literature [<xref rid="B2" ref-type="bibr">2</xref>, <xref rid="B13" ref-type="bibr">13</xref>–<xref rid="B15" ref-type="bibr">15</xref>], in the case reported here, cryosurgery proved to be a simple, fast, and extremely effective procedure in the treatment of hemangioma of the oral cavity.</p><p>Although there are no studies comparing efficacy among the various cryosurgical techniques, application of liquid nitrogen with a cotton swab has proven to be practical and effective in the treatment of several oral lesions [<xref rid="B2" ref-type="bibr">2</xref>, <xref rid="B8" ref-type="bibr">8</xref>, <xref rid="B15" ref-type="bibr">15</xref>]. However, in the present study, due to the size of the lesion, we believed that a deeper cryonecrosis would be necessary and, therefore, we chose to use a liquid nitrogen spray technique, as reported in the study conducted by Hartmann et al. [<xref rid="B13" ref-type="bibr">13</xref>].</p><p>In agreement with Graham and Barham [<xref rid="B5" ref-type="bibr">5</xref>] and Gallardo et al. (2000) [<xref rid="B16" ref-type="bibr">16</xref>], although a number of cryogenic agents are available in the market, currently, liquid nitrogen should be the agent of choice because it reaches the lowest temperatures (approximately 196°C) and is a relatively inexpensive and easy-to-handle substance. As observed in the case reported here, treatment of oral lesions using cryosurgery is well accepted by patients and the procedure is well tolerated under local anesthesia, as also reported by Li [<xref rid="B17" ref-type="bibr">17</xref>].</p><p>Cryotherapy is considered simple, fast, and easy to perform, and the formation of edema and erythema in the area exposed to the cryogenic agent is evident immediately after the procedure. There are no reports of postoperative infection, difficulty breathing, or allergic reactions to the cryogenic agent. All studies have reported the presence of mild pain, which is managed solely with the use of peripherally acting analgesics [<xref rid="B12" ref-type="bibr">12</xref>, <xref rid="B15" ref-type="bibr">15</xref>, <xref rid="B18" ref-type="bibr">18</xref>, <xref rid="B19" ref-type="bibr">19</xref>].</p></sec><sec id="sec4"><title>4. Final Considerations</title><p>Based on data reported in the literature and obtained in the present case report, cryosurgery is a safe and extremely effective procedure in the treatment of lesions occurring in the oral and maxillofacial region. Nevertheless, despite the scientifically proven efficacy and routine application of cryosurgery across many medical specialties, this treatment modality is still rarely used in dentistry.</p></sec></body><back><sec><title>Disclosure</title><p>The authors have no financial relationships relevant to this article to disclose.</p></sec><sec><title>Conflicts of Interest</title><p>The authors declare that there are no conflicts of interest regarding the publication of this article.</p></sec><ref-list><ref id="B1"><label>1</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Chen</surname><given-names>T. H.</given-names></name><name><surname>Huang</surname><given-names>C. J.</given-names></name><name><surname>Huang</surname><given-names>Y. Y.</given-names></name></person-group><article-title>In vivo detection of cryosurgery using multiphoton and harmonic generation microscopy</article-title><source><italic>Medical Engineering & Physics</italic></source><year>2008</year><volume>30</volume><issue>8</issue><fpage>984</fpage><lpage>988</lpage><pub-id pub-id-type="doi">10.1016/j.medengphy.2008.01.009</pub-id><pub-id pub-id-type="pmid">18378485</pub-id></element-citation></ref><ref id="B2"><label>2</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Yeh</surname><given-names>C.-J.</given-names></name></person-group><article-title>Simple cryosurgical treatment for oral lesions</article-title><source><italic>International Journal of Oral and Maxillofacial Surgery</italic></source><year>2000</year><volume>29</volume><issue>3</issue><fpage>212</fpage><lpage>216</lpage><pub-id pub-id-type="other">2-s2.0-0034201138</pub-id><pub-id pub-id-type="doi">10.1016/S0901-5027(00)80096-X</pub-id><pub-id pub-id-type="pmid">10970086</pub-id></element-citation></ref><ref id="B3"><label>3</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Benaglia</surname><given-names>M. B.</given-names></name><name><surname>Jardim</surname><given-names>E. C. G.</given-names></name><name><surname>Mendonça</surname><given-names>J. C. G.</given-names></name></person-group><article-title>Cryosurgery in dentistry: advantages and disadvantages</article-title><source><italic>Brazilian Journal of Surgery and Clinical Research</italic></source><year>2014</year><volume>7</volume><issue>3</issue><fpage>58</fpage><lpage>67</lpage></element-citation></ref><ref id="B4"><label>4</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Rubinsky</surname><given-names>B.</given-names></name><name><surname>Onik</surname><given-names>G.</given-names></name></person-group><article-title>Cryosurgery: advances in the application of low temperatures to medicine</article-title><source><italic>International Journal of Refrigeration</italic></source><year>1991</year><volume>14</volume><issue>4</issue><fpage>190</fpage><lpage>199</lpage><pub-id pub-id-type="other">2-s2.0-0026189413</pub-id><pub-id pub-id-type="doi">10.1016/0140-7007(91)90003-Y</pub-id></element-citation></ref><ref id="B5"><label>5</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Graham</surname><given-names>G. F.</given-names></name><name><surname>Barham</surname><given-names>K. L.</given-names></name></person-group><article-title>Cryosurgery</article-title><source><italic>Current Problems in Dermatology</italic></source><year>2003</year><volume>15</volume><issue>6</issue><fpage>223</fpage><lpage>250</lpage><pub-id pub-id-type="doi">10.1016/s1040-0486(03)00099-1</pub-id><pub-id pub-id-type="other">2-s2.0-0347411158</pub-id></element-citation></ref><ref id="B6"><label>6</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Gage</surname><given-names>A. A.</given-names></name><name><surname>Baust</surname><given-names>J.</given-names></name></person-group><article-title>Mechanisms of tissue injury in cryosurgery</article-title><source><italic>Cryobiology</italic></source><year>1998</year><volume>37</volume><issue>3</issue><fpage>171</fpage><lpage>186</lpage><pub-id pub-id-type="doi">10.1006/cryo.1998.2115</pub-id><pub-id pub-id-type="other">2-s2.0-0032209678</pub-id><pub-id pub-id-type="pmid">9787063</pub-id></element-citation></ref><ref id="B7"><label>7</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Prasad</surname><given-names>M.</given-names></name><name><surname>Kale</surname><given-names>T. P.</given-names></name><name><surname>Halli</surname><given-names>R.</given-names></name><name><surname>Kotrashetti</surname><given-names>S. M.</given-names></name><name><surname>Baliga</surname><given-names>S. D.</given-names></name></person-group><article-title>Liquid nitrogen cryotherapy in the management of oral lesions: a retrospective clinical study</article-title><source><italic>Journal of Maxillofacial and Oral Surgery</italic></source><year>2009</year><volume>8</volume><issue>1</issue><fpage>40</fpage><lpage>42</lpage><pub-id pub-id-type="doi">10.1007/s12663-009-0010-2</pub-id><pub-id pub-id-type="pmid">23139468</pub-id></element-citation></ref><ref id="B8"><label>8</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Toida</surname><given-names>M.</given-names></name><name><surname>Ishimaru</surname><given-names>J.-I.</given-names></name><name><surname>Hobo</surname><given-names>N.</given-names></name></person-group><article-title>A simple cryosurgical method for treatment of oral mucous cysts</article-title><source><italic>International Journal of Oral and Maxillofacial Surgery</italic></source><year>1993</year><volume>22</volume><issue>6</issue><fpage>353</fpage><lpage>355</lpage><pub-id pub-id-type="other">2-s2.0-0027726794</pub-id><pub-id pub-id-type="doi">10.1016/S0901-5027(05)80666-6</pub-id><pub-id pub-id-type="pmid">8106810</pub-id></element-citation></ref><ref id="B9"><label>9</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Zakrzewska</surname><given-names>J. M.</given-names></name></person-group><article-title>Cryotherapy for trigeminal neuralgia: A 10 year audit</article-title><source><italic>British Journal of Oral and Maxillofacial Surgery</italic></source><year>1991</year><volume>29</volume><issue>1</issue><fpage>1</fpage><lpage>4</lpage><pub-id pub-id-type="other">2-s2.0-0026057225</pub-id><pub-id pub-id-type="doi">10.1016/0266-4356(91)90162-X</pub-id><pub-id pub-id-type="pmid">2004067</pub-id></element-citation></ref><ref id="B10"><label>10</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Fernández-Vozmediano</surname><given-names>J.</given-names></name><name><surname>Armario-Hita</surname><given-names>J. C.</given-names></name><name><surname>Nieto-Herce</surname><given-names>A.</given-names></name></person-group><article-title>Action protocol in vascular changes of perioral localization. (I): Hemangiomas</article-title><source><italic>Piel</italic></source><year>2006</year><volume>21</volume><issue>3</issue><fpage>157</fpage><lpage>165</lpage><pub-id pub-id-type="other">2-s2.0-77950510534</pub-id><pub-id pub-id-type="doi">10.1016/S0213-9251(06)72456-X</pub-id></element-citation></ref><ref id="B11"><label>11</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Carnasciali</surname><given-names>M. C. G.</given-names></name><name><surname>Marinho</surname><given-names>S. A.</given-names></name><name><surname>Pototski</surname><given-names>M.</given-names></name><name><surname>Amenábar</surname><given-names>J. M.</given-names></name></person-group><article-title>A criocirurgia como tratamento das lesões bucais</article-title><source><italic>Perspectives in Oral Sciences</italic></source><year>2010</year><volume>2</volume><issue>1</issue><fpage>55</fpage><lpage>58</lpage></element-citation></ref><ref id="B12"><label>12</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Hausamen</surname><given-names>J.-E.</given-names></name></person-group><article-title>The basis, technique and indication for cryosurgery in tumours of the oral cavity and face</article-title><source><italic>Journal of Maxillofacial Surgery</italic></source><year>1975</year><volume>3</volume><issue>C</issue><fpage>41</fpage><lpage>49</lpage><pub-id pub-id-type="other">2-s2.0-0016608476</pub-id><pub-id pub-id-type="doi">10.1016/S0301-0503(75)80013-0</pub-id><pub-id pub-id-type="pmid">47884</pub-id></element-citation></ref><ref id="B13"><label>13</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Hartmann</surname><given-names>P. K.</given-names></name><name><surname>Verne</surname><given-names>D.</given-names></name><name><surname>Davis</surname><given-names>R. G.</given-names></name></person-group><article-title>Cryosurgical removal of a large oral hemangioma</article-title><source><italic>Oral Surgery, Oral Medicine, Oral Pathology</italic></source><year>1984</year><volume>58</volume><issue>3</issue><fpage>280</fpage><lpage>282</lpage><pub-id pub-id-type="other">2-s2.0-0021181973</pub-id><pub-id pub-id-type="doi">10.1016/0030-4220(84)90053-7</pub-id></element-citation></ref><ref id="B14"><label>14</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Tal</surname><given-names>H.</given-names></name></person-group><article-title>Cryosurgical treatment of hemangiomas of the lip</article-title><source><italic>Oral Surgery, Oral Medicine, Oral Pathology</italic></source><year>1992</year><volume>73</volume><issue>6</issue><fpage>650</fpage><lpage>654</lpage><pub-id pub-id-type="other">2-s2.0-0026636803</pub-id><pub-id pub-id-type="doi">10.1016/0030-4220(92)90002-8</pub-id></element-citation></ref><ref id="B15"><label>15</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Bekke</surname><given-names>J. P. H.</given-names></name><name><surname>Baart</surname><given-names>J. A.</given-names></name></person-group><article-title>Six years' experience with cryosurgery in the oral cavity</article-title><source><italic>International Journal of Oral Surgery</italic></source><year>1979</year><volume>8</volume><issue>4</issue><fpage>251</fpage><lpage>270</lpage><pub-id pub-id-type="other">2-s2.0-0018702417</pub-id><pub-id pub-id-type="doi">10.1016/S0300-9785(79)80047-2</pub-id><pub-id pub-id-type="pmid">94318</pub-id></element-citation></ref><ref id="B16"><label>16</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Gallardo</surname><given-names>J. L. H.</given-names></name><name><surname>Gómez</surname><given-names>F. M.</given-names></name><name><surname>León</surname><given-names>M. G.</given-names></name></person-group><article-title>Crioterapia: fundamentos físicos y técnicos</article-title><source><italic>SEMERGEN - Medicina de Familia</italic></source><year>2000</year><volume>26</volume><issue>1</issue><fpage>14</fpage><lpage>16</lpage><pub-id pub-id-type="doi">10.1016/S1138-3593(00)73523-4</pub-id></element-citation></ref><ref id="B17"><label>17</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Li</surname><given-names>Z.</given-names></name></person-group><article-title>Cryosurgery in 50 cases of tongue carcinoma</article-title><source><italic>Journal of Oral and Maxillofacial Surgery</italic></source><year>1991</year><volume>49</volume><issue>5</issue><fpage>504</fpage><lpage>506</lpage><pub-id pub-id-type="other">2-s2.0-0025829921</pub-id><pub-id pub-id-type="doi">10.1016/0278-2391(91)90176-M</pub-id><pub-id pub-id-type="pmid">2019897</pub-id></element-citation></ref><ref id="B18"><label>18</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Sako</surname><given-names>K.</given-names></name><name><surname>Marchetta</surname><given-names>F. C.</given-names></name><name><surname>Hayes</surname><given-names>R. L.</given-names></name></person-group><article-title>Cryotherapy of intraoral leukoplakia</article-title><source><italic>The American Journal of Surgery</italic></source><year>1972</year><volume>124</volume><issue>4</issue><fpage>482</fpage><lpage>484</lpage><pub-id pub-id-type="other">2-s2.0-0015419575</pub-id><pub-id pub-id-type="doi">10.1016/0002-9610(72)90071-2</pub-id><pub-id pub-id-type="pmid">5076162</pub-id></element-citation></ref><ref id="B19"><label>19</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Leopard</surname><given-names>P. J.</given-names></name></person-group><article-title>Cryosurgery, and its application to oral surgery</article-title><source><italic>British Journal of Oral Surgery</italic></source><year>1975</year><volume>13</volume><issue>2</issue><fpage>128</fpage><lpage>152</lpage><pub-id pub-id-type="other">2-s2.0-0016678652</pub-id><pub-id pub-id-type="doi">10.1016/0007-117X(75)90002-5</pub-id><pub-id pub-id-type="pmid">1059481</pub-id></element-citation></ref></ref-list></back><floats-group><fig id="fig1" orientation="portrait" position="float"><label>Figure 1</label><caption><p>Hemangiomatous lesion on the left lateral border of the tongue.</p></caption><graphic xlink:href="CRIOT2017-8529016.001"></graphic></fig><fig id="fig2" orientation="portrait" position="float"><label>Figure 2</label><caption><p>Diascopy (pressure on the lesion with a glass slide) showing color change.</p></caption><graphic xlink:href="CRIOT2017-8529016.002"></graphic></fig><fig id="fig3" orientation="portrait" position="float"><label>Figure 3</label><caption><p>Cryocautery system: liquid nitrogen container and pump system used in the present case.</p></caption><graphic xlink:href="CRIOT2017-8529016.003"></graphic></fig><fig id="fig4" orientation="portrait" position="float"><label>Figure 4</label><caption><p>Tongue pulled to the right and adjacent tissues protected by gauze with Vaseline.</p></caption><graphic xlink:href="CRIOT2017-8529016.004"></graphic></fig><fig id="fig5" orientation="portrait" position="float"><label>Figure 5</label><caption><p>Application of liquid nitrogen on the lesion.</p></caption><graphic xlink:href="CRIOT2017-8529016.005"></graphic></fig><fig id="fig6" orientation="portrait" position="float"><label>Figure 6</label><caption><p>(a) Appearance of the frozen lesion and (b) formation of perilesional edema and erythema in the immediate postoperative period.</p></caption><graphic xlink:href="CRIOT2017-8529016.006"></graphic></fig><fig id="fig7" orientation="portrait" position="float"><label>Figure 7</label><caption><p>Postoperative week 1.</p></caption><graphic xlink:href="CRIOT2017-8529016.007"></graphic></fig><fig id="fig8" orientation="portrait" position="float"><label>Figure 8</label><caption><p>Postoperative week 3.</p></caption><graphic xlink:href="CRIOT2017-8529016.008"></graphic></fig><fig id="fig9" orientation="portrait" position="float"><label>Figure 9</label><caption><p>Postoperative week 6.</p></caption><graphic xlink:href="CRIOT2017-8529016.009"></graphic></fig><fig id="fig10" orientation="portrait" position="float"><label>Figure 10</label><caption><p>Postoperative week 8.</p></caption><graphic xlink:href="CRIOT2017-8529016.010"></graphic></fig><fig id="fig11" orientation="portrait" position="float"><label>Figure 11</label><caption><p>Postoperative month 18.</p></caption><graphic xlink:href="CRIOT2017-8529016.011"></graphic></fig></floats-group></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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