Mandible metastasis of small cell lung cancer mimicking a residual cyst
Identifieur interne : 001B37 ( Pmc/Corpus ); précédent : 001B36; suivant : 001B38Mandible metastasis of small cell lung cancer mimicking a residual cyst
Auteurs : Renata Mendonça Moraes ; Fabio Abreu Alves ; Bruna Fernandes Do Carmo Carvalho ; Felipe D'Almeida Costa ; Rodrigo Nascimento Lopes ; Graziella Chagas JaguarSource :
- Autopsy & Case Reports [ 2236-1960 ] ; 2017.
Abstract
Small cell lung carcinoma (SCLC) is an uncommon tumor characterized by an aggressive behavior with early metastasis, usually to the contralateral lung, liver, brain, and bones. There are only five cases of this particular tumor metastasizing to the oral cavity described in the English literature. We present the case of metastatic SCLC in the mandible with radiographic findings resembling a residual cyst. A 66-year-old man with previous diagnosis and treatment for a SCLC was referred to the Stomatology Department with a history of persistent pain in the mandible 1 year after the inferior right pre-molar tooth extraction. The radiographic exam showed a well-delimited radiolucent area on that extracted tooth’s region resembling a residual cyst. Biopsy was performed yielding the diagnosis of metastatic SCLC. The patient was referred to the clinical oncologist for chemotherapy. Although uncommon, this tumor should be included in the differential diagnosis of jawbone lesions, particularly when the patient presents a previous diagnosis of SCLC.
Url:
DOI: 10.4322/acr.2017.003
PubMed: 28536686
PubMed Central: 5436920
Links to Exploration step
PMC:5436920Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Mandible metastasis of small cell lung cancer mimicking a residual cyst</title><author><name sortKey="Moraes, Renata Mendonca" sort="Moraes, Renata Mendonca" uniqKey="Moraes R" first="Renata Mendonça" last="Moraes">Renata Mendonça Moraes</name><affiliation><nlm:aff id="aff01">Stomatology Department - A.C. Camargo Cancer Center, São Paulo/SP –<country>Brazil</country>.</nlm:aff></affiliation></author><author><name sortKey="Alves, Fabio Abreu" sort="Alves, Fabio Abreu" uniqKey="Alves F" first="Fabio Abreu" last="Alves">Fabio Abreu Alves</name><affiliation><nlm:aff id="aff01">Stomatology Department - A.C. Camargo Cancer Center, São Paulo/SP –<country>Brazil</country>.</nlm:aff></affiliation><affiliation><nlm:aff id="aff02">Stomatology Department - Universidade de São Paulo, São Paulo/SP –<country>Brazil</country>.</nlm:aff></affiliation></author><author><name sortKey="Carvalho, Bruna Fernandes Do Carmo" sort="Carvalho, Bruna Fernandes Do Carmo" uniqKey="Carvalho B" first="Bruna Fernandes Do Carmo" last="Carvalho">Bruna Fernandes Do Carmo Carvalho</name><affiliation><nlm:aff id="aff01">Stomatology Department - A.C. Camargo Cancer Center, São Paulo/SP –<country>Brazil</country>.</nlm:aff></affiliation></author><author><name sortKey="Costa, Felipe D Almeida" sort="Costa, Felipe D Almeida" uniqKey="Costa F" first="Felipe D'Almeida" last="Costa">Felipe D'Almeida Costa</name><affiliation><nlm:aff id="aff03">Pathology Department - A.C. Camargo Cancer Center, São Paulo/SP –<country>Brazil</country>.</nlm:aff></affiliation></author><author><name sortKey="Lopes, Rodrigo Nascimento" sort="Lopes, Rodrigo Nascimento" uniqKey="Lopes R" first="Rodrigo Nascimento" last="Lopes">Rodrigo Nascimento Lopes</name><affiliation><nlm:aff id="aff01">Stomatology Department - A.C. Camargo Cancer Center, São Paulo/SP –<country>Brazil</country>.</nlm:aff></affiliation></author><author><name sortKey="Jaguar, Graziella Chagas" sort="Jaguar, Graziella Chagas" uniqKey="Jaguar G" first="Graziella Chagas" last="Jaguar">Graziella Chagas Jaguar</name><affiliation><nlm:aff id="aff01">Stomatology Department - A.C. Camargo Cancer Center, São Paulo/SP –<country>Brazil</country>.</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">28536686</idno><idno type="pmc">5436920</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5436920</idno><idno type="RBID">PMC:5436920</idno><idno type="doi">10.4322/acr.2017.003</idno><date when="2017">2017</date><idno type="wicri:Area/Pmc/Corpus">001B37</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001B37</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Mandible metastasis of small cell lung cancer mimicking a residual cyst</title><author><name sortKey="Moraes, Renata Mendonca" sort="Moraes, Renata Mendonca" uniqKey="Moraes R" first="Renata Mendonça" last="Moraes">Renata Mendonça Moraes</name><affiliation><nlm:aff id="aff01">Stomatology Department - A.C. Camargo Cancer Center, São Paulo/SP –<country>Brazil</country>.</nlm:aff></affiliation></author><author><name sortKey="Alves, Fabio Abreu" sort="Alves, Fabio Abreu" uniqKey="Alves F" first="Fabio Abreu" last="Alves">Fabio Abreu Alves</name><affiliation><nlm:aff id="aff01">Stomatology Department - A.C. Camargo Cancer Center, São Paulo/SP –<country>Brazil</country>.</nlm:aff></affiliation><affiliation><nlm:aff id="aff02">Stomatology Department - Universidade de São Paulo, São Paulo/SP –<country>Brazil</country>.</nlm:aff></affiliation></author><author><name sortKey="Carvalho, Bruna Fernandes Do Carmo" sort="Carvalho, Bruna Fernandes Do Carmo" uniqKey="Carvalho B" first="Bruna Fernandes Do Carmo" last="Carvalho">Bruna Fernandes Do Carmo Carvalho</name><affiliation><nlm:aff id="aff01">Stomatology Department - A.C. Camargo Cancer Center, São Paulo/SP –<country>Brazil</country>.</nlm:aff></affiliation></author><author><name sortKey="Costa, Felipe D Almeida" sort="Costa, Felipe D Almeida" uniqKey="Costa F" first="Felipe D'Almeida" last="Costa">Felipe D'Almeida Costa</name><affiliation><nlm:aff id="aff03">Pathology Department - A.C. Camargo Cancer Center, São Paulo/SP –<country>Brazil</country>.</nlm:aff></affiliation></author><author><name sortKey="Lopes, Rodrigo Nascimento" sort="Lopes, Rodrigo Nascimento" uniqKey="Lopes R" first="Rodrigo Nascimento" last="Lopes">Rodrigo Nascimento Lopes</name><affiliation><nlm:aff id="aff01">Stomatology Department - A.C. Camargo Cancer Center, São Paulo/SP –<country>Brazil</country>.</nlm:aff></affiliation></author><author><name sortKey="Jaguar, Graziella Chagas" sort="Jaguar, Graziella Chagas" uniqKey="Jaguar G" first="Graziella Chagas" last="Jaguar">Graziella Chagas Jaguar</name><affiliation><nlm:aff id="aff01">Stomatology Department - A.C. Camargo Cancer Center, São Paulo/SP –<country>Brazil</country>.</nlm:aff></affiliation></author></analytic><series><title level="j">Autopsy & Case Reports</title><idno type="eISSN">2236-1960</idno><imprint><date when="2017">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Small cell lung carcinoma (SCLC) is an uncommon tumor characterized by an aggressive behavior with early metastasis, usually to the contralateral lung, liver, brain, and bones. There are only five cases of this particular tumor metastasizing to the oral cavity described in the English literature. We present the case of metastatic SCLC in the mandible with radiographic findings resembling a residual cyst. A 66-year-old man with previous diagnosis and treatment for a SCLC was referred to the Stomatology Department with a history of persistent pain in the mandible 1 year after the inferior right pre-molar tooth extraction. The radiographic exam showed a well-delimited radiolucent area on that extracted tooth’s region resembling a residual cyst. Biopsy was performed yielding the diagnosis of metastatic SCLC. The patient was referred to the clinical oncologist for chemotherapy. Although uncommon, this tumor should be included in the differential diagnosis of jawbone lesions, particularly when the patient presents a previous diagnosis of SCLC.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Van Der Wall, Rif" uniqKey="Van Der Wall R">RIF Van der Wall</name></author><author><name sortKey="Buter, J" uniqKey="Buter J">J Buter</name></author><author><name sortKey="Van Der Waal, I" uniqKey="Van Der Waal I">I Van der Waal</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hirshberg, A" uniqKey="Hirshberg A">A Hirshberg</name></author><author><name sortKey="Shnaiderman Shapiro, A" uniqKey="Shnaiderman Shapiro A">A Shnaiderman-Shapiro</name></author><author><name sortKey="Kaplan, I" uniqKey="Kaplan I">I Kaplan</name></author><author><name sortKey="Berger, R" uniqKey="Berger R">R Berger</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Murillo, J" uniqKey="Murillo J">J Murillo</name></author><author><name sortKey="Bagan, Jv" uniqKey="Bagan J">JV Bagan</name></author><author><name sortKey="Hens, E" uniqKey="Hens E">E Hens</name></author><author><name sortKey="Diaz, Jm" uniqKey="Diaz J">JM Diaz</name></author><author><name sortKey="Leopoldo, M" uniqKey="Leopoldo M">M Leopoldo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Allon, I" uniqKey="Allon I">I Allon</name></author><author><name sortKey="Pessing, A" uniqKey="Pessing A">A Pessing</name></author><author><name sortKey="Kaplan, I" uniqKey="Kaplan I">I Kaplan</name></author><author><name sortKey="Allon, Dm" uniqKey="Allon D">DM Allon</name></author><author><name sortKey="Hirshberg, A" uniqKey="Hirshberg A">A Hirshberg</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Schneider, Km" uniqKey="Schneider K">KM Schneider</name></author><author><name sortKey="Martinez, Ay" uniqKey="Martinez A">AY Martinez</name></author><author><name sortKey="Guglielmi, M" uniqKey="Guglielmi M">M Guglielmi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kim, Ry" uniqKey="Kim R">RY Kim</name></author><author><name sortKey="Perry, Sr" uniqKey="Perry S">SR Perry</name></author><author><name sortKey="Levy, Ds" uniqKey="Levy D">DS Levy</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lim, Sy" uniqKey="Lim S">SY Lim</name></author><author><name sortKey="Kim, Sa" uniqKey="Kim S">SA Kim</name></author><author><name sortKey="Ahn, Sg" uniqKey="Ahn S">SG Ahn</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pektas, Zo" uniqKey="Pektas Z">ZO Pektas</name></author><author><name sortKey="Gunhan, O" uniqKey="Gunhan O">O Gunhan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Owosho, Aa" uniqKey="Owosho A">AA Owosho</name></author><author><name sortKey="Xu, B" uniqKey="Xu B">B Xu</name></author><author><name sortKey="Kadempour, A" uniqKey="Kadempour A">A Kadempour</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kamangar, F" uniqKey="Kamangar F">F Kamangar</name></author><author><name sortKey="Dores, Gm" uniqKey="Dores G">GM Dores</name></author><author><name sortKey="Anderson, Wf" uniqKey="Anderson W">WF Anderson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Van Meerbeeck, Jp" uniqKey="Van Meerbeeck J">JP Van Meerbeeck</name></author><author><name sortKey="Fennell, Da" uniqKey="Fennell D">DA Fennell</name></author><author><name sortKey="De Ruysscher, Dkm" uniqKey="De Ruysscher D">DKM De Ruysscher</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kato, Y" uniqKey="Kato Y">Y Kato</name></author><author><name sortKey="Ferguson, Tb" uniqKey="Ferguson T">TB Ferguson</name></author><author><name sortKey="Bennett, De" uniqKey="Bennett D">DE Bennett</name></author><author><name sortKey="Burford, Th" uniqKey="Burford T">TH Burford</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jackman, Dm" uniqKey="Jackman D">DM Jackman</name></author><author><name sortKey="Johnson, Be" uniqKey="Johnson B">BE Johnson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bodner, L" uniqKey="Bodner L">L Bodner</name></author><author><name sortKey="Sion Vardy, N" uniqKey="Sion Vardy N">N Sion-Vardy</name></author><author><name sortKey="Geffen, Db" uniqKey="Geffen D">DB Geffen</name></author><author><name sortKey="Nash, M" uniqKey="Nash M">M Nash</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hirshberg, A" uniqKey="Hirshberg A">A Hirshberg</name></author><author><name sortKey="Leibovich, P" uniqKey="Leibovich P">P Leibovich</name></author><author><name sortKey="Buchner, A" uniqKey="Buchner A">A Buchner</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Seoane, J" uniqKey="Seoane J">J Seoane</name></author><author><name sortKey="Van Der Waal, I" uniqKey="Van Der Waal I">I Van der Waal</name></author><author><name sortKey="Van Der Waal, Ri" uniqKey="Van Der Waal R">RI Van der Waal</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Shen, Ml" uniqKey="Shen M">ML Shen</name></author><author><name sortKey="Kang, J" uniqKey="Kang J">J Kang</name></author><author><name sortKey="Wen, Yl" uniqKey="Wen Y">YL Wen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Siriwardena, Bsms" uniqKey="Siriwardena B">BSMS Siriwardena</name></author><author><name sortKey="Jayasooriya, Pr" uniqKey="Jayasooriya P">PR Jayasooriya</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nawale, Kk" uniqKey="Nawale K">KK Nawale</name></author><author><name sortKey="Vyas, M" uniqKey="Vyas M">M Vyas</name></author><author><name sortKey="Kane, S" uniqKey="Kane S">S Kane</name></author><author><name sortKey="Patil, A" uniqKey="Patil A">A Patil</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Maschino, F" uniqKey="Maschino F">F Maschino</name></author><author><name sortKey="Guillet, J" uniqKey="Guillet J">J Guillet</name></author><author><name sortKey="Curien, R" uniqKey="Curien R">R Curien</name></author><author><name sortKey="Dolivet, G" uniqKey="Dolivet G">G Dolivet</name></author><author><name sortKey="Bravetti, P" uniqKey="Bravetti P">P Bravetti</name></author></analytic></biblStruct></listBibl></div1></back></TEI><pmc article-type="case-report"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Autops Case Rep</journal-id><journal-id journal-id-type="iso-abbrev">Autops Case Rep</journal-id><journal-title-group><journal-title>Autopsy & Case Reports</journal-title></journal-title-group><issn pub-type="epub">2236-1960</issn><publisher><publisher-name>São Paulo, SP: Universidade de São Paulo, Hospital Universitário</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">28536686</article-id><article-id pub-id-type="pmc">5436920</article-id><article-id pub-id-type="publisher-id">autopsy-07-01037</article-id><article-id pub-id-type="doi">10.4322/acr.2017.003</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article / Clinical Case Report</subject></subj-group></article-categories><title-group><article-title>Mandible metastasis of small cell lung cancer mimicking a residual cyst</article-title><alt-title alt-title-type="running-title">Mandible metastasis of small cell lung cancer mimicking a residual cyst</alt-title><alt-title alt-title-type="running-authors">Moraes RM, Alves FA, Carvalho BFC, Costa FDA, Lopes RN, Jaguar GC.</alt-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Moraes</surname><given-names>Renata Mendonça</given-names></name><xref ref-type="aff" rid="aff01">a</xref></contrib><contrib contrib-type="author"><name><surname>Alves</surname><given-names>Fabio Abreu</given-names></name><xref ref-type="aff" rid="aff01">a</xref><xref ref-type="aff" rid="aff02">b</xref></contrib><contrib contrib-type="author"><name><surname>Carvalho</surname><given-names>Bruna Fernandes do Carmo</given-names></name><xref ref-type="aff" rid="aff01">a</xref></contrib><contrib contrib-type="author"><name><surname>Costa</surname><given-names>Felipe D'Almeida</given-names></name><xref ref-type="aff" rid="aff03">c</xref></contrib><contrib contrib-type="author"><name><surname>Lopes</surname><given-names>Rodrigo Nascimento</given-names></name><xref ref-type="aff" rid="aff01">a</xref></contrib><contrib contrib-type="author" corresp="yes"><name><surname>Jaguar</surname><given-names>Graziella Chagas</given-names></name><xref ref-type="aff" rid="aff01">a</xref></contrib><aff id="aff01"><label>a</label>Stomatology Department - A.C. Camargo Cancer Center, São Paulo/SP –<country>Brazil</country>.</aff><aff id="aff02"><label>b</label>Stomatology Department - Universidade de São Paulo, São Paulo/SP –<country>Brazil</country>.</aff><aff id="aff03"><label>c</label>Pathology Department - A.C. Camargo Cancer Center, São Paulo/SP –<country>Brazil</country>.</aff></contrib-group><author-notes><fn fn-type="COI-statement"><p>Conflict of interest: None</p></fn><corresp id="c01">Correspondence
Graziella Chagas Jaguar
Stomatology Department - A.C. Camargo Cancer Center
Rua Prof. Antônio Prudente, 211 – Liberdade – São Paulo/SP – Brazil
CEP: 01509-900
Phone: +55 (11) 2189-5129
<email>graziaju@yahoo.com.br</email></corresp></author-notes><pub-date pub-type="epub"><day>30</day><month>3</month><year>2017</year></pub-date><pub-date pub-type="collection"><season>Jan-Mar</season><year>2017</year></pub-date><volume>7</volume><issue>1</issue><fpage>37</fpage><lpage>41</lpage><history><date date-type="received"><day>27</day><month>11</month><year>2016</year></date><date date-type="accepted"><day>19</day><month>1</month><year>2017</year></date></history><permissions><copyright-statement>Autopsy and Case Reports. ISSN 2236-1960. Copyright © 2017.</copyright-statement><copyright-year>2017</copyright-year><copyright-holder>Autopsy and Case Reports</copyright-holder><license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by-nc/4.0/"><license-p>This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium provided the article is properly cited.</license-p></license></permissions><abstract><p>Small cell lung carcinoma (SCLC) is an uncommon tumor characterized by an aggressive behavior with early metastasis, usually to the contralateral lung, liver, brain, and bones. There are only five cases of this particular tumor metastasizing to the oral cavity described in the English literature. We present the case of metastatic SCLC in the mandible with radiographic findings resembling a residual cyst. A 66-year-old man with previous diagnosis and treatment for a SCLC was referred to the Stomatology Department with a history of persistent pain in the mandible 1 year after the inferior right pre-molar tooth extraction. The radiographic exam showed a well-delimited radiolucent area on that extracted tooth’s region resembling a residual cyst. Biopsy was performed yielding the diagnosis of metastatic SCLC. The patient was referred to the clinical oncologist for chemotherapy. Although uncommon, this tumor should be included in the differential diagnosis of jawbone lesions, particularly when the patient presents a previous diagnosis of SCLC.</p></abstract><kwd-group kwd-group-type="author"><title>Keywords</title><kwd>Neoplasm Metastasis</kwd><kwd>Diagnosis</kwd><kwd>Oral</kwd><kwd>Small Cell Lung Carcinoma</kwd></kwd-group></article-meta></front><body><sec sec-type="intro"><title>INTRODUCTION</title><p>Metastases to the oral cavity is uncommon, representing nearly 1% of all oral cavity malignancies, and are associated with bad prognosis, with the survival time ranging between 3.7 months to 8.25 months.<xref rid="B001" ref-type="bibr">1</xref><sup>-</sup><xref rid="B004" ref-type="bibr">4</xref> Generally, the jaw is more commonly involved than the oral cavity’s soft tissues.<xref rid="B002" ref-type="bibr">2</xref> Breast, lung, kidney, bone, and colon malignancy are most commonly related to oral metastasis, in that this descending order.<xref rid="B005" ref-type="bibr">5</xref> In men, oral metastases derive most commonly from lung cancer. Non-small-cell lung cancer (NSCLC) accounts for 10-20% of all oral metastatic tumors, while oral metastases from (SCLC) are rarely reported in the English literature.<xref rid="B006" ref-type="bibr">6</xref><sup>-</sup><xref rid="B009" ref-type="bibr">9</xref> Herein, we present an uncommon case of metastatic SCLC to the mandible, which was initially interpreted as a residual cyst due to its clinical and imaging characteristics.</p></sec><sec><title>CASE REPORT</title><p>A 66-year-old man was referred to the Stomatology Department complaining of pain in the right mandible over the past year. He reported the exodontia of the first inferior right premolar 1 year ago, which after 4 months, became the site of the current complaint. His medical history included the diagnosis of metastatic prostate adenocarcinoma being treated with goserelin acetate (Zoladex®) over the last 8 years. An SCLC and bone metastasis from the prostate adenocarcinoma were also diagnosed in the past year, and treated with cisplatin (CCDP) and zoledronic acid (Zometa®). Intraoral examination revealed a slightly bluish area located in the overlying mucosa of the edentulous alveolus of the right mandible (first premolar). X-ray revealed a unilocular, oval radiolucency of 0.5 × 0.7 cm with well-defined sclerotic borders (<xref ref-type="fig" rid="g01">Figure 1</xref>).</p><fig id="g01" fig-type="figure" orientation="portrait" position="float"><label>Figure 1</label><caption><title>Initial panoramic radiograph showing a radiolucent oval image with radiopaque halo in the premolar region (arrow).</title></caption><graphic xlink:href="autopsy-07-01037-g01"></graphic></fig><p>According to clinical and imaging findings, the main diagnostic hypothesis was a residual cyst. A surgical procedure was proposed and during surgery the solid macroscopic characteristics of the lesion corresponded to the cystic radiographic aspect. The histopathologic examination revealed remarkably basophilic irregular cells with scant cytoplasm and hyperchromatic nuclei exhibiting scattered crushing artifacts (<xref ref-type="fig" rid="g02">Figure 2A</xref>, <xref ref-type="fig" rid="g02">2B</xref> and <xref ref-type="fig" rid="g02">2C</xref>). The immunohistochemical study revealed positivity for citokeratin 7, chromogranin A, and TTF-1 (<xref ref-type="fig" rid="g02">Figure 2D</xref>, <xref ref-type="fig" rid="g03">3A</xref> and <xref ref-type="fig" rid="g03">3B</xref> respectively) rendering the diagnosis of metastatic SCLC.</p><fig id="g02" fig-type="figure" orientation="portrait" position="float"><label>Figure 2</label><caption><title>Photomicrography of the biopsy specimen showing in <bold>A </bold>and<bold> B</bold> - an infiltrative tumor composed of large cell blocks with irregular shapes and marked basophilia (H&E, 40X and 100X, respectively); <bold>C</bold> - Note that the cells had scant cytoplasm and hyperchromatic nuclei, some with crushing artifact (H&E, 400X). The immunohistochemical study showed in <bold>D</bold> positivity for cytokeratin 7 (200X).</title></caption><graphic xlink:href="autopsy-07-01037-g02"></graphic></fig><fig id="g03" fig-type="figure" orientation="portrait" position="float"><label>Figure 3</label><caption><title>Photomicrography of the biopsy specimen showing in <bold>A</bold> positivity for chromogranin A (200X), and in <bold>B</bold> positivity for TTF-1 (200X).</title></caption><graphic xlink:href="autopsy-07-01037-g03"></graphic></fig><p>The patient was referred to the Clinical Oncology Department and underwent chemotherapy with paclitaxel 60 mg/m<sup>2</sup>. After a 4-month follow-up, the patient was asymptomatic and the x-ray showed signs of bone neoformation (<xref ref-type="fig" rid="g04">Figure 4</xref>).</p><fig id="g04" fig-type="figure" orientation="portrait" position="float"><label>Figure 4</label><caption><title>Panoramic radiograph 1 month after chemotherapy, showing new bone formation in the previously metastatic region.</title></caption><graphic xlink:href="autopsy-07-01037-g04"></graphic></fig></sec><sec sec-type="discussion"><title>DISCUSSION</title><p>Lung cancer classification comprises two large groups: the NSCLC and the SCLC. NSCLC accounts for up to 80% of all lung cancers comprising adenocarcinoma, squamous cell carcinoma, and large cell carcinoma.<xref rid="B010" ref-type="bibr">10</xref> On the other hand, the SCLC, which is of neuroendocrine origin, represents the remaining 20% of all lung cancer cases,<xref rid="B011" ref-type="bibr">11</xref> has an aggressive behavior, and is strongly associated with cigarette smoking. The SCLC frequently (60-65%) metastasize in the early stages of the disease.<xref rid="B012" ref-type="bibr">12</xref><sup>,</sup><xref rid="B013" ref-type="bibr">13</xref> However, as far as we know, to date, there are only five reported cases of metastatic SCLC to the oral cavity.<xref rid="B006" ref-type="bibr">6</xref><sup>-</sup><xref rid="B009" ref-type="bibr">9</xref> The case presented herein showed an unusual SCLC metastasis to the mandible, which was initially misinterpreted as a residual cyst.</p><p>Hirshberg et al.<xref rid="B002" ref-type="bibr">2</xref> reported 673 cases of metastatic oral tumors from 1916 to 2006, 112 cases (16.6%) of which originated in the lung and 58 (8.6%) cases were found in the jaw. This study showed a male predominance with a mean age of 52 years.<xref rid="B002" ref-type="bibr">2</xref> Smaller series endorsed Hishberg et al.’s observation.<xref rid="B001" ref-type="bibr">1</xref><sup>,</sup><xref rid="B003" ref-type="bibr">3</xref><sup>,</sup><xref rid="B007" ref-type="bibr">7</xref><sup>,</sup><xref rid="B014" ref-type="bibr">14</xref><sup>-</sup><xref rid="B020" ref-type="bibr">20</xref> However, most of these studies did not specify the lung cancer phenotype. Kim et al.<xref rid="B006" ref-type="bibr">6</xref> reported one case of metastatic SCLC in a 60-year-old male patient presenting as a pedunculated and granular lesion on the right side of the tongue. Pektas and Gunhan<xref rid="B008" ref-type="bibr">8</xref> reported the case of a 50-year-old woman with an erythematous, hemorrhagic soft tissue mass on the left mandibular gingiva. Lim et al.<xref rid="B007" ref-type="bibr">7</xref> conducted a retrospective analysis of 41 Korean patients diagnosed with metastatic oral tumors and the lung was the second most common primary site (n = 9: 22%) with adenocarcinoma as the most common histologic variant, with only two cases of SCLC. The authors did not specify their clinical presentation.<xref rid="B007" ref-type="bibr">7</xref> In a recent study with 44 patients with metastatic solid tumors to the oral cavity, Owosho et al.<xref rid="B009" ref-type="bibr">9</xref> reported one patient with SCLC presenting a non-healing tooth infection as the clinical presentation of oral metastasis.</p><p>The clinical features of metastatic lesions differ depending on the involved site in the oral cavity. In the jawbones, most patients complain of swelling, pain, paresthesia and numbness. Usually, a rapid growing exophytic mass, particularly in the molar region, is observed, as well as misleading presentations such as toothache, dentoalveolar swelling, and loose teeth.<xref rid="B001" ref-type="bibr">1</xref><sup>,</sup><xref rid="B003" ref-type="bibr">3</xref><sup>,</sup><xref rid="B007" ref-type="bibr">7</xref><sup>,</sup><xref rid="B014" ref-type="bibr">14</xref><sup>-</sup><xref rid="B020" ref-type="bibr">20</xref> In contrast to the reported cases of SCLC, which were clinically expressed as masses<xref rid="B006" ref-type="bibr">6</xref><sup>,</sup><xref rid="B008" ref-type="bibr">8</xref> or dental infections,<xref rid="B009" ref-type="bibr">9</xref> our case was characterized by an altered staining of the mucosa, which appeared bluish, and associated with pain. In agreement with the literature, the accurate diagnosis of oral metastasis may become difficult and challenging because of the unspecific characteristics of such lesions.<xref rid="B002" ref-type="bibr">2</xref><sup>,</sup><xref rid="B008" ref-type="bibr">8</xref><sup>,</sup><xref rid="B016" ref-type="bibr">16</xref><sup>,</sup><xref rid="B017" ref-type="bibr">17</xref><sup>,</sup><xref rid="B020" ref-type="bibr">20</xref></p><p>Radiographically, most cases of metastatic lesions present as osteolytic areas poorly defined with a “moth eaten” appearance.<xref rid="B002" ref-type="bibr">2</xref> The imaging study of our patient was quite different presenting a well-defined margin of the lesion. Consequently, the hypothesis of metastatic SCLC of the mandible was not initially taken into account. Based on the clinical/radiograph findings and previous history of the first premolar’s exodontia, the lesion was initially considered as an odontogenic lesion.</p><p>In this case, we emphasize the different forms of clinical and imaging presentation of oral metastases eventually mimicking benign lesions. Thus, it is important to add metastatic lesions in jawbone lesions as a differential diagnosis, especially when the patient has a previous history of cancer.</p></sec></body><back><fn-group><fn fn-type="other"><p>Moraes RM, Alves FA, Carvalho BFC, Costa FDA, Lopes RN, Jaguar GC. Mandible metastasis of small cell lung cancer mimicking a residual cyst. Autopsy Case Rep [Internet]. 2017;7(1):37-41. <ext-link ext-link-type="uri" xlink:href="http://dx.doi.org/10.4322/acr.2017.003">http://dx.doi.org/10.4322/acr.2017.003</ext-link></p></fn></fn-group><ref-list><title>REFERENCES</title><ref id="B001"><label>1</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name name-style="western"><surname>Van der Wall</surname><given-names>RIF</given-names></name>, <name name-style="western"><surname>Buter</surname><given-names>J</given-names></name>, <name name-style="western"><surname>Van der Waal</surname><given-names>I</given-names></name></person-group><article-title>Oral metastases: report of 24 cases</article-title>. <source>Br J Oral Maxillofac Surg</source>. <year>2003</year>;<volume>41</volume>(<issue>1</issue>):<fpage>3</fpage>-<lpage>6</lpage>. PMid: <ext-link ext-link-type="uri" xlink:href="http://dx.doi.org/10.1016/S0266-4356(02)00301-7">http://dx.doi.org/10.1016/S0266-4356(02)00301-7</ext-link>. <pub-id pub-id-type="pmid">12576032</pub-id></mixed-citation></ref><ref id="B002"><label>2</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name name-style="western"><surname>Hirshberg</surname><given-names>A</given-names></name>, <name name-style="western"><surname>Shnaiderman-Shapiro</surname><given-names>A</given-names></name>, <name name-style="western"><surname>Kaplan</surname><given-names>I</given-names></name>, <name name-style="western"><surname>Berger</surname><given-names>R</given-names></name></person-group><article-title>Metastatic tumours to the oral cavity- Pathogenesis and analysis of 673 cases</article-title>. <source>Oral Oncol</source>. <year>2008</year>;<volume>44</volume>(<issue>8</issue>):<fpage>743</fpage>-<lpage>52</lpage>. PMid: <ext-link ext-link-type="uri" xlink:href="http://dx.doi.org/10.1016/j.oraloncology.2007.09.012">http://dx.doi.org/10.1016/j.oraloncology.2007.09.012</ext-link>. <pub-id pub-id-type="pmid">18061527</pub-id></mixed-citation></ref><ref id="B003"><label>3</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name name-style="western"><surname>Murillo</surname><given-names>J</given-names></name>, <name name-style="western"><surname>Bagan</surname><given-names>JV</given-names></name>, <name name-style="western"><surname>Hens</surname><given-names>E</given-names></name>, <name name-style="western"><surname>Diaz</surname><given-names>JM</given-names></name>, <name name-style="western"><surname>Leopoldo</surname><given-names>M</given-names></name></person-group><article-title>Tumors metastasizing to the oral cavity: a study of 16 cases</article-title>. <source>J Oral Maxillofac Surg</source>. <year>2013</year>;<volume>71</volume>(<issue>9</issue>):<fpage>1545</fpage>-<lpage>51</lpage>. PMid: <ext-link ext-link-type="uri" xlink:href="http://dx.doi.org/10.1016/j.joms.2013.03.017">http://dx.doi.org/10.1016/j.joms.2013.03.017</ext-link>. <pub-id pub-id-type="pmid">23800673</pub-id></mixed-citation></ref><ref id="B004"><label>4</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name name-style="western"><surname>Allon</surname><given-names>I</given-names></name>, <name name-style="western"><surname>Pessing</surname><given-names>A</given-names></name>, <name name-style="western"><surname>Kaplan</surname><given-names>I</given-names></name>, <name name-style="western"><surname>Allon</surname><given-names>DM</given-names></name>, <name name-style="western"><surname>Hirshberg</surname><given-names>A</given-names></name></person-group><article-title>Metastatic tumors to the gingiva and the presence of teeth as a contributing factor: a literature analysis</article-title>. <source>J Periodontol</source>. <year>2014</year>;<volume>85</volume>(<issue>1</issue>):<fpage>132</fpage>-<lpage>9</lpage>. PMid: <ext-link ext-link-type="uri" xlink:href="http://dx.doi.org/10.1902/jop.2013.130118">http://dx.doi.org/10.1902/jop.2013.130118</ext-link>. <pub-id pub-id-type="pmid">23646853</pub-id></mixed-citation></ref><ref id="B005"><label>5</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name name-style="western"><surname>Schneider</surname><given-names>KM</given-names></name>, <name name-style="western"><surname>Martinez</surname><given-names>AY</given-names></name>, <name name-style="western"><surname>Guglielmi</surname><given-names>M</given-names></name></person-group><article-title>Large cell neuroendocrine carcinoma: topic review and a unique case of metastasis to the mandible</article-title>. <source>J Maxillofac Oral Surg</source>. <year>2015</year>;<volume>14</volume>(<issue>1</issue>, <supplement>Suppl 1</supplement>):<fpage>120</fpage>-<lpage>6</lpage>. PMid: <ext-link ext-link-type="uri" xlink:href="http://dx.doi.org/10.1007/s12663-012-0362-x">http://dx.doi.org/10.1007/s12663-012-0362-x</ext-link>. <pub-id pub-id-type="pmid">25861184</pub-id></mixed-citation></ref><ref id="B006"><label>6</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name name-style="western"><surname>Kim</surname><given-names>RY</given-names></name>, <name name-style="western"><surname>Perry</surname><given-names>SR</given-names></name>, <name name-style="western"><surname>Levy</surname><given-names>DS</given-names></name></person-group><article-title>Metastatic carcinoma to the tongue: a report of two cases and a review of the literature</article-title>. <source>Cancer</source>. <year>1979</year>;<volume>43</volume>(<issue>1</issue>):<fpage>386</fpage>-<lpage>9</lpage>. PMid: <ext-link ext-link-type="uri" xlink:href="http://dx.doi.org/10.1002/1097-0142(197901)43:1<386::AID-CNCR2820430154>3.0.CO;2-G">http://dx.doi.org/10.1002/1097-0142(197901)43:1<386::AID-CNCR2820430154>3.0.CO;2-G</ext-link>. <pub-id pub-id-type="pmid">216477</pub-id></mixed-citation></ref><ref id="B007"><label>7</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name name-style="western"><surname>Lim</surname><given-names>SY</given-names></name>, <name name-style="western"><surname>Kim</surname><given-names>SA</given-names></name>, <name name-style="western"><surname>Ahn</surname><given-names>SG</given-names></name>, <etal>et al</etal></person-group><article-title>Metastatic tumours to the jaws and oral soft tissues: a retrospective analysis of 41 Korean patients</article-title>. <source>Int J Oral Maxillofac Surg</source>. <year>2006</year>;<volume>35</volume>(<issue>5</issue>):<fpage>412</fpage>-<lpage>5</lpage>. PMid: <ext-link ext-link-type="uri" xlink:href="http://dx.doi.org/10.1016/j.ijom.2005.12.001">http://dx.doi.org/10.1016/j.ijom.2005.12.001</ext-link>. <pub-id pub-id-type="pmid">16473498</pub-id></mixed-citation></ref><ref id="B008"><label>8</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name name-style="western"><surname>Pektas</surname><given-names>ZO</given-names></name>, <name name-style="western"><surname>Gunhan</surname><given-names>O</given-names></name></person-group><article-title>Cytologically diagnosed metastatic small cell lung carcinoma in the mandibular soft tissue</article-title>. <source>Saudi Med J</source>. <year>2013</year>;<volume>34</volume>(<issue>5</issue>):<fpage>539</fpage>-<lpage>41</lpage>. PMid:<pub-id pub-id-type="pmid">23677273</pub-id></mixed-citation></ref><ref id="B009"><label>9</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name name-style="western"><surname>Owosho</surname><given-names>AA</given-names></name>, <name name-style="western"><surname>Xu</surname><given-names>B</given-names></name>, <name name-style="western"><surname>Kadempour</surname><given-names>A</given-names></name>, <etal>et al</etal></person-group><article-title>Metastatic solid tumors to the jaw and oral soft tissue: a retrospective clinical analysis of 44 patients from a single institution</article-title>. <source>J Craniomaxillofac Surg</source>. <year>2016</year>;<volume>44</volume>(<issue>8</issue>):<fpage>1047</fpage>-<lpage>53</lpage>. PMid: <ext-link ext-link-type="uri" xlink:href="http://dx.doi.org/10.1016/j.jcms.2016.05.013">http://dx.doi.org/10.1016/j.jcms.2016.05.013</ext-link>. <pub-id pub-id-type="pmid">27270028</pub-id></mixed-citation></ref><ref id="B010"><label>10</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name name-style="western"><surname>Kamangar</surname><given-names>F</given-names></name>, <name name-style="western"><surname>Dores</surname><given-names>GM</given-names></name>, <name name-style="western"><surname>Anderson</surname><given-names>WF</given-names></name></person-group><article-title>Patterns of cancer incidence, mortality, and prevalence across five continents: defining priorities to reduce cancer disparities in different geographic regions of the world</article-title>. <source>J Clin Oncol</source>. <year>2006</year>;<volume>24</volume>(<issue>14</issue>):<fpage>2137</fpage>-<lpage>50</lpage>. PMid: <ext-link ext-link-type="uri" xlink:href="http://dx.doi.org/10.1200/JCO.2005.05.2308">http://dx.doi.org/10.1200/JCO.2005.05.2308</ext-link>. <pub-id pub-id-type="pmid">16682732</pub-id></mixed-citation></ref><ref id="B011"><label>11</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name name-style="western"><surname>Van Meerbeeck</surname><given-names>JP</given-names></name>, <name name-style="western"><surname>Fennell</surname><given-names>DA</given-names></name>, <name name-style="western"><surname>De Ruysscher</surname><given-names>DKM</given-names></name></person-group><article-title>Small cell lung cancer</article-title>. <source>Lancet</source>. <year>2011</year>;<volume>378</volume>(<issue>9804</issue>):<fpage>1741</fpage>-<lpage>55</lpage>. PMid: <ext-link ext-link-type="uri" xlink:href="http://dx.doi.org/10.1016/S0140-6736(11)60165-7">http://dx.doi.org/10.1016/S0140-6736(11)60165-7</ext-link>. <pub-id pub-id-type="pmid">21565397</pub-id></mixed-citation></ref><ref id="B012"><label>12</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name name-style="western"><surname>Kato</surname><given-names>Y</given-names></name>, <name name-style="western"><surname>Ferguson</surname><given-names>TB</given-names></name>, <name name-style="western"><surname>Bennett</surname><given-names>DE</given-names></name>, <name name-style="western"><surname>Burford</surname><given-names>TH</given-names></name></person-group><article-title>Oat cell carcinoma of the lung: a review of 138 cases</article-title>. <source>Cancer</source>. <year>1969</year>;<volume>23</volume>(<issue>3</issue>):<fpage>517</fpage>-<lpage>24</lpage>. PMid: <ext-link ext-link-type="uri" xlink:href="http://dx.doi.org/10.1002/1097-0142(196903)23:3<517::AID-CNCR2820230301>3.0.CO;2-L">http://dx.doi.org/10.1002/1097-0142(196903)23:3<517::AID-CNCR2820230301>3.0.CO;2-L</ext-link>. <pub-id pub-id-type="pmid">5766496</pub-id></mixed-citation></ref><ref id="B013"><label>13</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name name-style="western"><surname>Jackman</surname><given-names>DM</given-names></name>, <name name-style="western"><surname>Johnson</surname><given-names>BE</given-names></name></person-group><article-title>Small-cell lung cancer</article-title>. <source>Lancet</source>. <year>2005</year>;<volume>366</volume>(<issue>9494</issue>):<fpage>1385</fpage>-<lpage>96</lpage>. PMid: <ext-link ext-link-type="uri" xlink:href="http://dx.doi.org/10.1016/S0140-6736(05)67569-1">http://dx.doi.org/10.1016/S0140-6736(05)67569-1</ext-link>. <pub-id pub-id-type="pmid">16226617</pub-id></mixed-citation></ref><ref id="B014"><label>14</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name name-style="western"><surname>Bodner</surname><given-names>L</given-names></name>, <name name-style="western"><surname>Sion-Vardy</surname><given-names>N</given-names></name>, <name name-style="western"><surname>Geffen</surname><given-names>DB</given-names></name>, <name name-style="western"><surname>Nash</surname><given-names>M</given-names></name></person-group><article-title>Metastatic tumors to the jaws: a report of eight new cases</article-title>. <source>Med Oral Patol Oral Cir Bucal</source>. <year>2006</year>;<volume>11</volume>(<issue>2</issue>):<fpage>E132</fpage>-<lpage>5</lpage>. PMid:<pub-id pub-id-type="pmid">16505790</pub-id></mixed-citation></ref><ref id="B015"><label>15</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name name-style="western"><surname>Hirshberg</surname><given-names>A</given-names></name>, <name name-style="western"><surname>Leibovich</surname><given-names>P</given-names></name>, <name name-style="western"><surname>Buchner</surname><given-names>A</given-names></name></person-group><article-title>Metastatic tumors to the jawbones: analysis of 390 cases</article-title>. <source>J Oral Pathol Med</source>. <year>1994</year>;<volume>23</volume>(<issue>8</issue>):<fpage>337</fpage>-<lpage>41</lpage>. PMid: <ext-link ext-link-type="uri" xlink:href="http://dx.doi.org/10.1111/j.1600-0714.1994.tb00072.x">http://dx.doi.org/10.1111/j.1600-0714.1994.tb00072.x</ext-link>. <pub-id pub-id-type="pmid">7815371</pub-id></mixed-citation></ref><ref id="B016"><label>16</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name name-style="western"><surname>Seoane</surname><given-names>J</given-names></name>, <name name-style="western"><surname>Van der Waal</surname><given-names>I</given-names></name>, <name name-style="western"><surname>Van der Waal</surname><given-names>RI</given-names></name>, <etal>et al</etal></person-group><article-title>Metastatic tumours to the oral cavity: a survival study with a special focus on gingival metastases</article-title>. <source>J Clin Periodontol</source>. <year>2009</year>;<volume>36</volume>(<issue>6</issue>):<fpage>488</fpage>-<lpage>92</lpage>. PMid: <ext-link ext-link-type="uri" xlink:href="http://dx.doi.org/10.1111/j.1600-051X.2009.01407.x">http://dx.doi.org/10.1111/j.1600-051X.2009.01407.x</ext-link>. <pub-id pub-id-type="pmid">19508248</pub-id></mixed-citation></ref><ref id="B017"><label>17</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name name-style="western"><surname>Shen</surname><given-names>ML</given-names></name>, <name name-style="western"><surname>Kang</surname><given-names>J</given-names></name>, <name name-style="western"><surname>Wen</surname><given-names>YL</given-names></name>, <etal>et al</etal></person-group><article-title>Metastatic tumors to the oral and maxillofacial region: a retrospective study of 19 cases in West China and review of the Chinese and English literature</article-title>. <source>J Oral Maxillofac Surg</source>. <year>2009</year>;<volume>67</volume>(<issue>4</issue>):<fpage>718</fpage>-<lpage>37</lpage>. PMid: <ext-link ext-link-type="uri" xlink:href="http://dx.doi.org/10.1016/j.joms.2008.06.032">http://dx.doi.org/10.1016/j.joms.2008.06.032</ext-link>. <pub-id pub-id-type="pmid">19304027</pub-id></mixed-citation></ref><ref id="B018"><label>18</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name name-style="western"><surname>Siriwardena</surname><given-names>BSMS</given-names></name>, <name name-style="western"><surname>Jayasooriya</surname><given-names>PR</given-names></name></person-group><article-title>Palitha Ratnayake, Tilakaratne WM. Metastatic tumours of the oral and maxillofacial region: a retrospective analysis of 18 cases</article-title>. <source>Merit Res J Biochem Bioinform.</source><year>2013</year>;<volume>1</volume>(<issue>1</issue>):<fpage>1</fpage>-<lpage>4</lpage>.</mixed-citation></ref><ref id="B019"><label>19</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name name-style="western"><surname>Nawale</surname><given-names>KK</given-names></name>, <name name-style="western"><surname>Vyas</surname><given-names>M</given-names></name>, <name name-style="western"><surname>Kane</surname><given-names>S</given-names></name>, <name name-style="western"><surname>Patil</surname><given-names>A</given-names></name></person-group><article-title>Metastatic tumors in the jaw bones: a retrospective clinicopathological study of 12 cases at Tertiary Cancer Center</article-title>. <source>J Oral Maxillofac Pathol</source>. <year>2016</year>;<volume>20</volume>(<issue>2</issue>):<fpage>252</fpage>-<lpage>5</lpage>. PMid: <ext-link ext-link-type="uri" xlink:href="http://dx.doi.org/10.4103/0973-029X.185920">http://dx.doi.org/10.4103/0973-029X.185920</ext-link>. <pub-id pub-id-type="pmid">27601818</pub-id></mixed-citation></ref><ref id="B020"><label>20</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name name-style="western"><surname>Maschino</surname><given-names>F</given-names></name>, <name name-style="western"><surname>Guillet</surname><given-names>J</given-names></name>, <name name-style="western"><surname>Curien</surname><given-names>R</given-names></name>, <name name-style="western"><surname>Dolivet</surname><given-names>G</given-names></name>, <name name-style="western"><surname>Bravetti</surname><given-names>P</given-names></name></person-group><article-title>Oral metastasis: a report of 23 cases</article-title>. <source>Int J Oral Maxillofac Surg</source>. <year>2013</year>;<volume>42</volume>(<issue>2</issue>):<fpage>164</fpage>-<lpage>8</lpage>. PMid: <ext-link ext-link-type="uri" xlink:href="http://dx.doi.org/10.1016/j.ijom.2012.10.029">http://dx.doi.org/10.1016/j.ijom.2012.10.029</ext-link>. <pub-id pub-id-type="pmid">23196066</pub-id></mixed-citation></ref></ref-list></back></pmc></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Santé/explor/EdenteV2/Data/Pmc/Corpus
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001B37 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Pmc/Corpus/biblio.hfd -nk 001B37 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Santé
|area= EdenteV2
|flux= Pmc
|étape= Corpus
|type= RBID
|clé= PMC:5436920
|texte= Mandible metastasis of small cell lung cancer mimicking a residual cyst
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Pmc/Corpus/RBID.i -Sk "pubmed:28536686" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Pmc/Corpus/biblio.hfd \
| NlmPubMed2Wicri -a EdenteV2
| This area was generated with Dilib version V0.6.32. |  |