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A new biological approach to guided bone and tissue regeneration

Identifieur interne : 001990 ( Pmc/Corpus ); précédent : 001989; suivant : 001991

A new biological approach to guided bone and tissue regeneration

Auteurs : Marco Montanari ; Michele Callea ; Izzet Yavuz ; Michele Maglione

Source :

RBID : PMC:3644911

Abstract

The purpose of this study was to determine the potential of platelet-rich fibrin (PRF) membranes used for guided bone and tissue regeneration. A patient with insufficient alveolar ridge width in aesthetic zone was enrolled. The patient's blood was centrifuged to obtain PRF membranes. Autogenous bone graft was mixed with bovine hydroxyapatite, PRF particles and applied to fill the defect. Five PRF membranes were placed over the bone mix. After 4 months a cone-beam CT was performed to evaluate bone regeneration. The use of PRF as cover membrane permitted a rapid epithelisation and represented an effective barrier versus epithelial cell penetration. After 4 months the site appeared precociously healed and the bone volume increased. This new approach represents a predictable method of augmenting deficient alveolar ridges. Guided bone regeneration with PRF showed limitation compared with guided bone regeneration using collagen membrane in terms of bone gain. The association of collagen membrane and PRF could be a good association.


Url:
DOI: 10.1136/bcr-2012-008240
PubMed: 23576648
PubMed Central: 3644911

Links to Exploration step

PMC:3644911

Le document en format XML

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<addr-line>Unit of Dentistry for Special Care, Department of Oral Science</addr-line>
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<institution>University of Bologna</institution>
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<addr-line>Bologna</addr-line>
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<name sortKey="Callea, Michele" sort="Callea, Michele" uniqKey="Callea M" first="Michele" last="Callea">Michele Callea</name>
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<institution>Institute for Maternal and Child Health—IRCCS “Burlo Garofolo”</institution>
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<addr-line>Trieste</addr-line>
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<name sortKey="Yavuz, Izzet" sort="Yavuz, Izzet" uniqKey="Yavuz I" first="Izzet" last="Yavuz">Izzet Yavuz</name>
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<addr-line>Department of Pediatric Dentistry</addr-line>
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<institution>Dicle University Faculty of Dentistry, 21280</institution>
<addr-line>Diyarbakır</addr-line>
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<country>Turkey</country>
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<p>The purpose of this study was to determine the potential of platelet-rich fibrin (PRF) membranes used for guided bone and tissue regeneration. A patient with insufficient alveolar ridge width in aesthetic zone was enrolled. The patient's blood was centrifuged to obtain PRF membranes. Autogenous bone graft was mixed with bovine hydroxyapatite, PRF particles and applied to fill the defect. Five PRF membranes were placed over the bone mix. After 4 months a cone-beam CT was performed to evaluate bone regeneration. The use of PRF as cover membrane permitted a rapid epithelisation and represented an effective barrier versus epithelial cell penetration. After 4 months the site appeared precociously healed and the bone volume increased. This new approach represents a predictable method of augmenting deficient alveolar ridges. Guided bone regeneration with PRF showed limitation compared with guided bone regeneration using collagen membrane in terms of bone gain. The association of collagen membrane and PRF could be a good association.</p>
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<label>Correspondence to</label>
Dr Michele Callea, Department of Pediatric Stomatology, Institute for Maternal and Child Health – IRCCS “Burlo Garofolo”- Trieste, Italy;
<email>mcallea@gmail.com</email>
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<abstract>
<p>The purpose of this study was to determine the potential of platelet-rich fibrin (PRF) membranes used for guided bone and tissue regeneration. A patient with insufficient alveolar ridge width in aesthetic zone was enrolled. The patient's blood was centrifuged to obtain PRF membranes. Autogenous bone graft was mixed with bovine hydroxyapatite, PRF particles and applied to fill the defect. Five PRF membranes were placed over the bone mix. After 4 months a cone-beam CT was performed to evaluate bone regeneration. The use of PRF as cover membrane permitted a rapid epithelisation and represented an effective barrier versus epithelial cell penetration. After 4 months the site appeared precociously healed and the bone volume increased. This new approach represents a predictable method of augmenting deficient alveolar ridges. Guided bone regeneration with PRF showed limitation compared with guided bone regeneration using collagen membrane in terms of bone gain. The association of collagen membrane and PRF could be a good association.</p>
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